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ONTOLOGY REPORT - ANNOTATIONS


Term:phentolamine
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Accession:CHEBI:8081 term browser browse the term
Definition:A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Synonyms:exact_synonym: 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol
 related_synonym: 2-(N-(m-hydroxyphenyl)-p-toluidinomethyl)imidazoline;   Formula=C17H19N3O;   InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);   InChIKey=MRBDMNSDAVCSSF-UHFFFAOYSA-N;   Phentolamine mesylate;   Regitina;   Regitine;   Rogitine;   SMILES=Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1;   fentolamina;   phentolaminum
 xref: CAS:50-60-2 "ChemIDplus";   DrugBank:DB00692;   Drug_Central:2142 "DrugCentral";   HMDB:HMDB0014830;   KEGG:D00509;   KEGG:D08362;   LINCS:LSM-4022
 xref_mesh: MESH:D010646
 xref: PMID:23438114 "Europe PMC";   PMID:23522530 "Europe PMC";   PMID:23658874 "Europe PMC";   PMID:23666670 "Europe PMC";   PMID:23887290 "Europe PMC";   PMID:23926134 "Europe PMC";   Patent:US2503059;   Reaxys:272944 "Reaxys";   Wikipedia:Phentolamine


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phentolamine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:6480464
G Adra1b adrenoceptor alpha 1B JBrowse link 10 29,392,762 29,450,644 RGD:6480464
G Adra1d adrenoceptor alpha 1D JBrowse link 3 124,129,558 124,145,566 RGD:6480464
G Adra2a adrenoceptor alpha 2A JBrowse link 1 274,766,283 274,769,083 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Ggt1 gamma-glutamyltransferase 1 JBrowse link 20 14,019,723 14,045,781 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:6480464
G Pygl glycogen phosphorylase L JBrowse link 6 92,597,759 92,643,734 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc22a3 solute carrier family 22 member 3 JBrowse link 1 48,433,079 48,521,261 RGD:6480464
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:6480464
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:6480464
G Sult1a1 sulfotransferase family 1A member 1 JBrowse link 1 198,100,586 198,104,106 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      application 19225
        pharmaceutical 19089
          drug 19089
            cardiovascular drug 7552
              vasodilator agent 5671
                phentolamine 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    main group molecular entity 19534
                      s-block molecular entity 19319
                        hydrogen molecular entity 19310
                          hydrides 18237
                            inorganic hydride 17105
                              pnictogen hydride 17063
                                nitrogen hydride 16886
                                  azane 16564
                                    ammonia 16561
                                      organic amino compound 16560
                                        aromatic amine 13570
                                          anilines 12281
                                            substituted aniline 11776
                                              phentolamine 21
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