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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:afzelin
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Accession:CHEBI:80790 term browser browse the term
Definition:A glycosyloxyflavone that is kaempferol attached to an alpha-L-rhamnosyl residue at position 3 via a glycosidic linkage.
Synonyms:exact_synonym: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside
 related_synonym: 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-ol;   5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl alpha-L-rhamnoside;   Formula=C21H20O10;   InChI=1S/C21H20O10/c1-8-15(25)17(27)18(28)21(29-8)31-20-16(26)14-12(24)6-11(23)7-13(14)30-19(20)9-2-4-10(22)5-3-9/h2-8,15,17-18,21-25,27-28H,1H3/t8-,15-,17+,18+,21-/m0/s1;   InChIKey=SOSLMHZOJATCCP-AEIZVZFYSA-N;   Kaempferin;   Kaempferol 3-O-alpha-L-rhamnopyranoside;   Kaempferol 3-O-alpha-L-rhamnoside;   SMILES=C1=C(C=C(C2=C1OC(=C(C2=O)O[C@H]3[C@@H]([C@@H]([C@H]([C@@H](O3)C)O)O)O)C4=CC=C(C=C4)O)O)O;   kaempferol-3-rhamnoside;   kaempherol 3-O-alpha-rhamnoside
 alt_id: CHEBI:145298
 xref: CAS:482-39-3;   KEGG:C16911;   KNApSAcK:C00005140;   LIPID_MAPS_instance:LMPK12111842
 xref_mesh: MESH:C477954
 xref: PDBeChem:AFE;   PMID:23626759;   PMID:24423008;   PMID:24642906;   PMID:27287415;   PMID:27861739;   PMID:27992083;   PMID:29497935;   PMID:29715535;   PMID:29967287;   PMID:30080245;   PMID:30450965;   PMID:30990334;   PMID:31017255;   PMID:31323310;   PMID:31384828;   PMID:31401185;   Reaxys:1359648;   Wikipedia:Afzelin
 cyclic_relationship: is_conjugate_acid_of CHEBI:144433


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afzelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mitf melanocyte inducing transcription factor increases expression ISO afzelin results in increased expression of MITF mRNA; afzelin results in increased expression of MITF protein CTD PMID:27287415 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Tyr tyrosinase multiple interactions
increases expression
ISO afzelin results in increased expression of and results in increased activity of TYR protein
afzelin results in increased expression of TYR mRNA
CTD PMID:27287415 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression ISO afzelin results in increased expression of TYRP1 mRNA; afzelin results in increased expression of TYRP1 protein CTD PMID:27287415 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        anti-inflammatory agent 14950
          afzelin 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  oxacycle 17185
                                    benzopyran 10135
                                      1-benzopyran 9851
                                        flavonoid 6374
                                          flavones 4166
                                            hydroxyflavone 4154
                                              flavonols 4070
                                                7-hydroxyflavonol 4049
                                                  kaempferol 167
                                                    afzelin 3
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