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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Phenoxybenzamine
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Accession:CHEBI:8077 term browser browse the term
Definition:An aromatic amine that has formula C18H22ClNO.
Synonyms:related_synonym: Formula=C18H22ClNO;   InChI=1S/C18H22ClNO/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17/h2-11,16H,12-15H2,1H3;   InChIKey=QZVCTJOXCFMACW-UHFFFAOYSA-N;   SMILES=CC(COc1ccccc1)N(CCCl)Cc1ccccc1;   dibenylin;   dibenyline;   dibenzyline;   phenoxybenzamine HCl;   phenoxybenzamine hydrochloride
 xref: CAS:59-96-1;   Drug_Central:2136;   HMDB:HMDB0015061;   KEGG:C07435;   KEGG:D08358;   LINCS:LSM-1729
 xref_mesh: MESH:D010643


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Phenoxybenzamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Phenoxybenzamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions EXP [chlorethylclonidine co-treated with Phenoxybenzamine] inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Phenoxybenzamine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein] CTD PMID:10416824 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions EXP Phenoxybenzamine binds to and results in decreased activity of ADRB1 protein CTD PMID:11886792 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Calca calcitonin-related polypeptide alpha affects activity EXP Phenoxybenzamine affects the activity of CALCA protein CTD PMID:7906887, PMID:8058111, PMID:10075105 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions
decreases expression
EXP Phenoxybenzamine inhibits the reaction [[Estrogens co-treated with Progesterone] results in increased expression of GAL mRNA]
Phenoxybenzamine results in decreased expression of GAL mRNA
CTD PMID:7512492, PMID:7537244 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Phenoxybenzamine results in increased expression of GFAP protein CTD PMID:17845906 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 decreases secretion EXP Phenoxybenzamine results in decreased secretion of GNRH1 protein CTD PMID:17845906 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Phenoxybenzamine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions EXP Phenoxybenzamine affects the reaction [Serotonin binds to HTR2A protein] CTD PMID:8627522 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Phenoxybenzamine inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein]; Phenoxybenzamine results in decreased secretion of and results in decreased expression of LHB protein CTD PMID:3953791 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Ncam1 neural cell adhesion molecule 1 affects localization
decreases expression
EXP Phenoxybenzamine affects the localization of NCAM1 protein modified form
Phenoxybenzamine results in decreased expression of NCAM1 protein modified form
CTD PMID:17845906 NCBI chr 8:53,836,797...54,134,881
Ensembl chr 8:53,839,098...53,901,358
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Phenoxybenzamine promotes the reaction [NCOA1 protein binds to NR1I3 protein] CTD PMID:31312845 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO Phenoxybenzamine promotes the reaction [NCOA3 protein binds to NR1I3 protein] CTD PMID:31312845 NCBI chr 3:162,692,176...162,788,582
Ensembl chr 3:162,692,185...162,787,548
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Phenoxybenzamine results in increased activity of NR1I2 protein
[Phenoxybenzamine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:31312845 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Phenoxybenzamine binds to and results in increased activity of NR1I3 protein alternative form; Phenoxybenzamine inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; Phenoxybenzamine promotes the reaction [NCOA1 protein binds to NR1I3 protein]; Phenoxybenzamine promotes the reaction [NCOA3 protein binds to NR1I3 protein] CTD PMID:31312845 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO Phenoxybenzamine results in decreased activity of NR3C1 protein CTD PMID:7887964, PMID:8838141 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
decreases activity
ISO Phenoxybenzamine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Phenoxybenzamine results in decreased activity of SLC22A1 protein
CTD PMID:12110607 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases activity
ISO Phenoxybenzamine inhibits the reaction [SLC22A2 protein affects the transport of Metformin]; Phenoxybenzamine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Phenoxybenzamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
Phenoxybenzamine results in decreased activity of SLC22A2 protein
CTD PMID:12110607, PMID:18728938, PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 decreases activity
multiple interactions
ISO Phenoxybenzamine results in decreased activity of SLC22A3 protein
Phenoxybenzamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:12110607 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 decreases expression EXP Phenoxybenzamine results in decreased expression of ST8SIA4 mRNA CTD PMID:17845906 NCBI chr 9:103,117,705...103,207,154
Ensembl chr 9:103,117,506...103,207,190
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      chemical role 19247
        base 16939
          Bronsted base 16938
            organic amino compound 16930
              aromatic amine 13604
                Phenoxybenzamine 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    main group molecular entity 19655
                      s-block molecular entity 19397
                        hydrogen molecular entity 19387
                          hydrides 18419
                            inorganic hydride 17380
                              pnictogen hydride 17349
                                nitrogen hydride 17216
                                  azane 16932
                                    ammonia 16931
                                      organic amino compound 16930
                                        aromatic amine 13604
                                          Phenoxybenzamine 20
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.