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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Phenoxybenzamine
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Accession:CHEBI:8077 term browser browse the term
Definition:An aromatic amine that has formula C18H22ClNO.
Synonyms:related_synonym: Formula=C18H22ClNO;   InChI=1S/C18H22ClNO/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17/h2-11,16H,12-15H2,1H3;   InChIKey=QZVCTJOXCFMACW-UHFFFAOYSA-N;   SMILES=CC(COc1ccccc1)N(CCCl)Cc1ccccc1;   dibenylin;   dibenyline;   dibenzyline;   phenoxybenzamine HCl;   phenoxybenzamine hydrochloride
 xref: CAS:59-96-1;   Drug_Central:2136;   HMDB:HMDB0015061;   KEGG:C07435;   KEGG:D08358;   LINCS:LSM-1729
 xref_mesh: MESH:D010643



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Phenoxybenzamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 decreases activity EXP Phenoxybenzamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435
JBrowse link
G ADRA1A adrenoceptor alpha 1A multiple interactions ISO [chlorethylclonidine co-treated with Phenoxybenzamine] inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Phenoxybenzamine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein] CTD PMID:10416824 NCBI chr 8:26,748,150...26,867,379
Ensembl chr 8:26,748,150...26,867,278
JBrowse link
G ADRB1 adrenoceptor beta 1 multiple interactions ISO Phenoxybenzamine binds to and results in decreased activity of ADRB1 protein CTD PMID:11886792 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP Phenoxybenzamine results in increased expression of ATF3 mRNA CTD PMID:32661532 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G CALCA calcitonin related polypeptide alpha affects activity ISO Phenoxybenzamine affects the activity of CALCA protein CTD PMID:7906887 PMID:8058111 PMID:10075105 NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP [Phenoxybenzamine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:31312845 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G EREG epiregulin decreases expression EXP Phenoxybenzamine results in decreased expression of EREG mRNA CTD PMID:32816093 NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749
JBrowse link
G GAL galanin and GMAP prepropeptide multiple interactions
decreases expression
ISO Phenoxybenzamine inhibits the reaction [[Estrogens co-treated with Progesterone] results in increased expression of GAL mRNA]
Phenoxybenzamine results in decreased expression of GAL mRNA
CTD PMID:7512492 PMID:7537244 NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175
JBrowse link
G GFAP glial fibrillary acidic protein increases expression ISO Phenoxybenzamine results in increased expression of GFAP protein CTD PMID:17845906 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GNRH1 gonadotropin releasing hormone 1 decreases secretion ISO Phenoxybenzamine results in decreased secretion of GNRH1 protein CTD PMID:17845906 NCBI chr 8:25,419,258...25,425,040
Ensembl chr 8:25,419,258...25,424,654
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP Phenoxybenzamine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HSF1 heat shock transcription factor 1 increases activity EXP Phenoxybenzamine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720
JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A multiple interactions ISO Phenoxybenzamine affects the reaction [Serotonin binds to HTR2A protein] CTD PMID:8627522 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076
JBrowse link
G IL24 interleukin 24 decreases expression EXP Phenoxybenzamine results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr 1:206,897,443...206,904,139
Ensembl chr 1:206,897,443...206,904,139
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions ISO Phenoxybenzamine inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein]; Phenoxybenzamine results in decreased secretion of and results in decreased expression of LHB protein CTD PMID:3953791 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase decreases expression EXP Phenoxybenzamine results in decreased expression of MET mRNA CTD PMID:32816093 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377
JBrowse link
G MT1M metallothionein 1M increases expression EXP Phenoxybenzamine results in increased expression of MT1M mRNA CTD PMID:32661532 NCBI chr16:56,632,659...56,633,981
Ensembl chr16:56,632,659...56,633,981
JBrowse link
G NCAM1 neural cell adhesion molecule 1 affects localization
decreases expression
ISO Phenoxybenzamine affects the localization of NCAM1 protein modified form
Phenoxybenzamine results in decreased expression of NCAM1 protein modified form
CTD PMID:17845906 NCBI chr11:112,961,420...113,278,436
Ensembl chr11:112,961,275...113,278,436
JBrowse link
G NCOA1 nuclear receptor coactivator 1 multiple interactions EXP Phenoxybenzamine promotes the reaction [NCOA1 protein binds to NR1I3 protein] CTD PMID:31312845 NCBI chr 2:24,491,254...24,770,702
Ensembl chr 2:24,491,254...24,770,702
JBrowse link
G NCOA3 nuclear receptor coactivator 3 multiple interactions EXP Phenoxybenzamine promotes the reaction [NCOA3 protein binds to NR1I3 protein] CTD PMID:31312845 NCBI chr20:47,501,887...47,656,872
Ensembl chr20:47,501,887...47,656,877
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
increases activity
EXP [Phenoxybenzamine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:31312845 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions EXP Phenoxybenzamine binds to and results in increased activity of NR1I3 protein alternative form; Phenoxybenzamine inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; Phenoxybenzamine promotes the reaction [NCOA1 protein binds to NR1I3 protein]; Phenoxybenzamine promotes the reaction [NCOA3 protein binds to NR1I3 protein] CTD PMID:31312845 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 decreases activity ISO Phenoxybenzamine results in decreased activity of NR3C1 protein CTD PMID:7887964 PMID:8838141 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions
decreases activity
EXP Phenoxybenzamine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Phenoxybenzamine results in decreased activity of SLC22A1 protein
CTD PMID:12110607 NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions
decreases activity
EXP Phenoxybenzamine inhibits the reaction [SLC22A2 protein affects the transport of Metformin]; Phenoxybenzamine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Phenoxybenzamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
Phenoxybenzamine results in decreased activity of SLC22A2 protein
CTD PMID:12110607 PMID:18728938 PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC22A3 solute carrier family 22 member 3 decreases activity
multiple interactions
EXP Phenoxybenzamine results in decreased activity of SLC22A3 protein
Phenoxybenzamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:12110607 NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577
JBrowse link
G ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 decreases expression ISO Phenoxybenzamine results in decreased expression of ST8SIA4 mRNA CTD PMID:17845906 NCBI chr 5:100,806,933...100,903,282
Ensembl chr 5:100,806,933...100,903,282
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      application 25180
        NMR chemical shift reference compound 20302
          ammonia 19957
            organic amino compound 19957
              aromatic amine 16213
                Phenoxybenzamine 27
Path 2
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  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    main group molecular entity 25840
                      s-block molecular entity 25160
                        hydrogen molecular entity 24759
                          hydrides 22971
                            inorganic hydride 20496
                              pnictogen hydride 20437
                                nitrogen hydride 20216
                                  azane 19958
                                    ammonia 19957
                                      organic amino compound 19957
                                        aromatic amine 16213
                                          Phenoxybenzamine 27
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