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G |
ABCB4 |
ATP binding cassette subfamily B member 4 |
decreases activity |
EXP |
Phenoxybenzamine results in decreased activity of ABCB4 protein |
CTD |
PMID:28437613 |
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NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435
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G |
ADRA1A |
adrenoceptor alpha 1A |
multiple interactions |
ISO |
[chlorethylclonidine co-treated with Phenoxybenzamine] inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Phenoxybenzamine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein] |
CTD |
PMID:10416824 |
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NCBI chr 8:26,748,150...26,867,379
Ensembl chr 8:26,748,150...26,867,278
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G |
ADRB1 |
adrenoceptor beta 1 |
multiple interactions |
ISO |
Phenoxybenzamine binds to and results in decreased activity of ADRB1 protein |
CTD |
PMID:11886792 |
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NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904
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G |
ATF3 |
activating transcription factor 3 |
increases expression |
EXP |
Phenoxybenzamine results in increased expression of ATF3 mRNA |
CTD |
PMID:32661532 |
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NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
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G |
CALCA |
calcitonin related polypeptide alpha |
affects activity |
ISO |
Phenoxybenzamine affects the activity of CALCA protein |
CTD |
PMID:7906887 PMID:8058111 PMID:10075105 |
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NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
multiple interactions |
EXP |
[Phenoxybenzamine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA |
CTD |
PMID:31312845 |
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NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
EREG |
epiregulin |
decreases expression |
EXP |
Phenoxybenzamine results in decreased expression of EREG mRNA |
CTD |
PMID:32816093 |
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NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749
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G |
GAL |
galanin and GMAP prepropeptide |
multiple interactions decreases expression |
ISO |
Phenoxybenzamine inhibits the reaction [[Estrogens co-treated with Progesterone] results in increased expression of GAL mRNA] Phenoxybenzamine results in decreased expression of GAL mRNA |
CTD |
PMID:7512492 PMID:7537244 |
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NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175
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G |
GFAP |
glial fibrillary acidic protein |
increases expression |
ISO |
Phenoxybenzamine results in increased expression of GFAP protein |
CTD |
PMID:17845906 |
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NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
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G |
GNRH1 |
gonadotropin releasing hormone 1 |
decreases secretion |
ISO |
Phenoxybenzamine results in decreased secretion of GNRH1 protein |
CTD |
PMID:17845906 |
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NCBI chr 8:25,419,258...25,425,040
Ensembl chr 8:25,419,258...25,424,654
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G |
GSTP1 |
glutathione S-transferase pi 1 |
multiple interactions |
EXP |
Phenoxybenzamine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] |
CTD |
PMID:23769903 |
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NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
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G |
HSF1 |
heat shock transcription factor 1 |
increases activity |
EXP |
Phenoxybenzamine results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
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NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720
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G |
HTR2A |
5-hydroxytryptamine receptor 2A |
multiple interactions |
ISO |
Phenoxybenzamine affects the reaction [Serotonin binds to HTR2A protein] |
CTD |
PMID:8627522 |
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NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076
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G |
IL24 |
interleukin 24 |
decreases expression |
EXP |
Phenoxybenzamine results in decreased expression of IL24 mRNA |
CTD |
PMID:32816093 |
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NCBI chr 1:206,897,443...206,904,139
Ensembl chr 1:206,897,443...206,904,139
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G |
LHB |
luteinizing hormone subunit beta |
multiple interactions |
ISO |
Phenoxybenzamine inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein]; Phenoxybenzamine results in decreased secretion of and results in decreased expression of LHB protein |
CTD |
PMID:3953791 |
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NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091
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G |
MET |
MET proto-oncogene, receptor tyrosine kinase |
decreases expression |
EXP |
Phenoxybenzamine results in decreased expression of MET mRNA |
CTD |
PMID:32816093 |
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NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377
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G |
MT1M |
metallothionein 1M |
increases expression |
EXP |
Phenoxybenzamine results in increased expression of MT1M mRNA |
CTD |
PMID:32661532 |
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NCBI chr16:56,632,659...56,633,981
Ensembl chr16:56,632,659...56,633,981
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G |
NCAM1 |
neural cell adhesion molecule 1 |
affects localization decreases expression |
ISO |
Phenoxybenzamine affects the localization of NCAM1 protein modified form Phenoxybenzamine results in decreased expression of NCAM1 protein modified form |
CTD |
PMID:17845906 |
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NCBI chr11:112,961,420...113,278,436
Ensembl chr11:112,961,275...113,278,436
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G |
NCOA1 |
nuclear receptor coactivator 1 |
multiple interactions |
EXP |
Phenoxybenzamine promotes the reaction [NCOA1 protein binds to NR1I3 protein] |
CTD |
PMID:31312845 |
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NCBI chr 2:24,491,254...24,770,702
Ensembl chr 2:24,491,254...24,770,702
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G |
NCOA3 |
nuclear receptor coactivator 3 |
multiple interactions |
EXP |
Phenoxybenzamine promotes the reaction [NCOA3 protein binds to NR1I3 protein] |
CTD |
PMID:31312845 |
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NCBI chr20:47,501,887...47,656,872
Ensembl chr20:47,501,887...47,656,877
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G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
multiple interactions increases activity |
EXP |
[Phenoxybenzamine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA |
CTD |
PMID:31312845 |
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NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
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G |
NR1I3 |
nuclear receptor subfamily 1 group I member 3 |
multiple interactions |
EXP |
Phenoxybenzamine binds to and results in increased activity of NR1I3 protein alternative form; Phenoxybenzamine inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; Phenoxybenzamine promotes the reaction [NCOA1 protein binds to NR1I3 protein]; Phenoxybenzamine promotes the reaction [NCOA3 protein binds to NR1I3 protein] |
CTD |
PMID:31312845 |
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NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244
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G |
NR3C1 |
nuclear receptor subfamily 3 group C member 1 |
decreases activity |
ISO |
Phenoxybenzamine results in decreased activity of NR3C1 protein |
CTD |
PMID:7887964 PMID:8838141 |
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NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
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G |
SLC22A1 |
solute carrier family 22 member 1 |
multiple interactions decreases activity |
EXP |
Phenoxybenzamine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Phenoxybenzamine results in decreased activity of SLC22A1 protein |
CTD |
PMID:12110607 |
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NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718
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G |
SLC22A2 |
solute carrier family 22 member 2 |
multiple interactions decreases activity |
EXP |
Phenoxybenzamine inhibits the reaction [SLC22A2 protein affects the transport of Metformin]; Phenoxybenzamine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Phenoxybenzamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] Phenoxybenzamine results in decreased activity of SLC22A2 protein |
CTD |
PMID:12110607 PMID:18728938 PMID:21599003 |
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NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
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G |
SLC22A3 |
solute carrier family 22 member 3 |
decreases activity multiple interactions |
EXP |
Phenoxybenzamine results in decreased activity of SLC22A3 protein Phenoxybenzamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:12110607 |
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NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577
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G |
ST8SIA4 |
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 |
decreases expression |
ISO |
Phenoxybenzamine results in decreased expression of ST8SIA4 mRNA |
CTD |
PMID:17845906 |
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NCBI chr 5:100,806,933...100,903,282
Ensembl chr 5:100,806,933...100,903,282
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