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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:toxoflavin
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Accession:CHEBI:80729 term browser browse the term
Definition:A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7.
Synonyms:exact_synonym: 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
 related_synonym: 1,6-dimethylpyrimido(5,4-e)-as-triazine-5,7(1H,6H)-dione;   1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione;   1-methylreumycin;   Formula=C7H7N5O2;   InChI=1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3;   InChIKey=SLGRAIAQIAUZAQ-UHFFFAOYSA-N;   NC72;   NSC67078;   PKF118-310;   SMILES=N1=CN=C2C(N1C)=NC(N(C2=O)C)=O;   toxoflavine;   xanthothricin;   xanthotricin
 xref: CAS:84-82-2;   KEGG:C16789
 xref_mesh: MESH:C009570
 xref: MetaCyc:CPD-21056;   PMID:14749129;   PMID:19662654;   PMID:24542943;   PMID:25806356;   PMID:25845410;   PMID:26077901;   PMID:26314431;   PMID:27070241;   PMID:27767379;   PMID:29235250;   PMID:29293506;   PMID:29807072;   PMID:5905124;   Reaxys:21014;   Wikipedia:Toxoflavin



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toxoflavin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [toxoflavin results in decreased activity of ERN1 protein]; [dihydrolipoic acid co-treated with toxoflavin] results in decreased activity of ERN1 protein; [Dithiothreitol co-treated with toxoflavin] results in decreased activity of ERN1 protein; [toxoflavin co-treated with Dithiothreitol] results in increased oxidation of ERN1 protein; Dithiothreitol promotes the reaction [toxoflavin results in decreased activity of ERN1 protein]; toxoflavin binds to and results in decreased activity of ERN1 protein; toxoflavin inhibits the reaction [Tunicamycin results in decreased sulfation of ERN1 protein]; toxoflavin inhibits the reaction [Tunicamycin results in increased phosphorylation of ERN1 protein] CTD PMID:35840659 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions ISO toxoflavin analog inhibits the reaction [[Dexamethasone co-treated with TNFSF11 protein] results in increased expression of P4HB protein] CTD PMID:39393751 NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO toxoflavin analog inhibits the reaction [[Dexamethasone co-treated with TNFSF11 protein] results in increased expression of P4HB protein] CTD PMID:39393751 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [toxoflavin inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]]; Acetylcysteine inhibits the reaction [toxoflavin inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]]; toxoflavin inhibits the reaction [Deoxyglucose results in increased splicing of XBP1 mRNA]; toxoflavin inhibits the reaction [Disulfiram results in increased splicing of XBP1 mRNA]; toxoflavin inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA] CTD PMID:35840659 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        antimicrobial agent 18578
          reumycin 4
            toxoflavin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organic heteropolycyclic compound 18651
                                    organic heterobicyclic compound 17545
                                      pyrimidotriazine 4
                                        1,6-didemethyltoxoflavin 4
                                          reumycin 4
                                            toxoflavin 4
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