Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:toxoflavin
go back to main search page
Accession:CHEBI:80729 term browser browse the term
Definition:A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7.
Synonyms:exact_synonym: 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
 related_synonym: 1,6-dimethylpyrimido(5,4-e)-as-triazine-5,7(1H,6H)-dione;   1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione;   1-methylreumycin;   Formula=C7H7N5O2;   InChI=1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3;   InChIKey=SLGRAIAQIAUZAQ-UHFFFAOYSA-N;   NC72;   NSC67078;   PKF118-310;   SMILES=N1=CN=C2C(N1C)=NC(N(C2=O)C)=O;   toxoflavine;   xanthothricin;   xanthotricin
 xref: CAS:84-82-2;   KEGG:C16789
 xref_mesh: MESH:C009570
 xref: MetaCyc:CPD-21056;   PMID:14749129;   PMID:19662654;   PMID:24542943;   PMID:25806356;   PMID:25845410;   PMID:26077901;   PMID:26314431;   PMID:27070241;   PMID:27767379;   PMID:29235250;   PMID:29293506;   PMID:29807072;   PMID:5905124;   Reaxys:21014;   Wikipedia:Toxoflavin


show annotations for term's descendants           Sort by:
toxoflavin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [toxoflavin results in decreased activity of ERN1 protein]; [dihydrolipoic acid co-treated with toxoflavin] results in decreased activity of ERN1 protein; [Dithiothreitol co-treated with toxoflavin] results in decreased activity of ERN1 protein; [toxoflavin co-treated with Dithiothreitol] results in increased oxidation of ERN1 protein; Dithiothreitol promotes the reaction [toxoflavin results in decreased activity of ERN1 protein]; toxoflavin binds to and results in decreased activity of ERN1 protein; toxoflavin inhibits the reaction [Tunicamycin results in decreased sulfation of ERN1 protein]; toxoflavin inhibits the reaction [Tunicamycin results in increased phosphorylation of ERN1 protein] CTD PMID:35840659 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions ISO toxoflavin analog inhibits the reaction [[Dexamethasone co-treated with TNFSF11 protein] results in increased expression of P4HB protein] CTD PMID:39393751 NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO toxoflavin analog inhibits the reaction [[Dexamethasone co-treated with TNFSF11 protein] results in increased expression of P4HB protein] CTD PMID:39393751 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [toxoflavin inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]]; Acetylcysteine inhibits the reaction [toxoflavin inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]]; toxoflavin inhibits the reaction [Deoxyglucose results in increased splicing of XBP1 mRNA]; toxoflavin inhibits the reaction [Disulfiram results in increased splicing of XBP1 mRNA]; toxoflavin inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA] CTD PMID:35840659 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        antimicrobial agent 18578
          reumycin 4
            toxoflavin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organic heteropolycyclic compound 18651
                                    organic heterobicyclic compound 17545
                                      pyrimidotriazine 4
                                        1,6-didemethyltoxoflavin 4
                                          reumycin 4
                                            toxoflavin 4
paths to the root