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ONTOLOGY REPORT - ANNOTATIONS


Term:all-trans-4-oxoretinoic acid
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Accession:CHEBI:80656 term browser browse the term
Definition:A retinoid that consists of all-trans-retinoic acid bearing an oxo substituent at position 4 on the cyclohexenyl ring.
Synonyms:exact_synonym: 4-oxoretinoic acid
 related_synonym: 4-oxo-all-trans-retinoic acid;   4-oxo-atRA;   Formula=C20H26O3;   InChI=1S/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/b8-6+,10-9+,14-7+,15-13+;   InChIKey=GGCUJPCCTQNTJF-FRCNGJHJSA-N;   SMILES=C\\C(\\C=C\\C1=C(C)C(=O)CCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
 xref: CAS:38030-57-8 "ChemIDplus";   HMDB:HMDB0006285;   KEGG:C16678
 xref_mesh: MESH:C002202
 xref: PMID:2051220 "Europe PMC";   PMID:25492813 "Europe PMC";   PMID:2772923 "Europe PMC";   PMID:435468 "Europe PMC";   Reaxys:2878846 "Reaxys"


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all-trans-4-oxoretinoic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aip aryl-hydrocarbon receptor-interacting protein JBrowse link 1 219,361,859 219,373,924 RGD:6480464
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:6480464
G Apod apolipoprotein D JBrowse link 11 72,705,204 72,726,263 RGD:6480464
G Cbx3 chromobox 3 JBrowse link 4 81,243,809 81,257,898 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6480464
G Cdkn1c cyclin-dependent kinase inhibitor 1C JBrowse link 1 216,661,067 216,663,791 RGD:6480464
G Ckb creatine kinase B JBrowse link 6 136,142,956 136,145,838 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Col4a2 collagen type IV alpha 2 chain JBrowse link 16 83,386,388 83,522,169 RGD:6480464
G Col6a1 collagen type VI alpha 1 chain JBrowse link 20 12,657,913 12,676,370 RGD:6480464
G Col8a2 collagen type VIII alpha 2 chain JBrowse link 5 144,308,527 144,335,142 RGD:6480464
G Crabp2 cellular retinoic acid binding protein 2 JBrowse link 2 187,322,416 187,326,794 RGD:6480464
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:6480464
G Cxcl3 chemokine (C-X-C motif) ligand 3 JBrowse link 14 18,820,168 18,839,659 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 JBrowse link 1 256,382,861 256,386,729 RGD:6480464
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 JBrowse link 9 81,968,285 81,998,213 RGD:6480464
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:6480464
G Dsc1 desmocollin 1 JBrowse link 18 11,877,918 11,906,828 RGD:6480464
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:6480464
G Dusp11 dual specificity phosphatase 11 JBrowse link 4 117,617,640 117,631,674 RGD:6480464
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 JBrowse link 20 31,055,292 31,072,469 RGD:6480464
G Emp1 epithelial membrane protein 1 JBrowse link 4 169,161,076 169,181,967 RGD:6480464
G Fabp5 fatty acid binding protein 5 JBrowse link 2 93,981,662 93,985,322 RGD:6480464
G Fam3c FAM3 metabolism regulating signaling molecule C JBrowse link 4 49,388,962 49,439,892 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6480464
G Fastk Fas-activated serine/threonine kinase JBrowse link 4 7,260,521 7,264,590 RGD:6480464
G Fgf1 fibroblast growth factor 1 JBrowse link 18 32,273,830 32,359,831 RGD:6480464
G Fkbp8 FKBP prolyl isomerase 8 JBrowse link 16 20,645,956 20,652,890 RGD:6480464
G Flg filaggrin JBrowse link 2 193,565,401 193,574,297 RGD:6480464
G Foxa1 forkhead box A1 JBrowse link 6 78,516,579 78,549,669 RGD:6480464
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:6480464
G Gata6 GATA binding protein 6 JBrowse link 18 2,415,821 2,447,087 RGD:6480464
G Gba glucosylceramidase beta JBrowse link 2 188,511,781 188,522,602 RGD:6480464
G Gdf15 growth differentiation factor 15 JBrowse link 16 20,555,395 20,557,978 RGD:6480464
G Gdf2 growth differentiation factor 2 JBrowse link 16 10,267,510 10,293,545 RGD:6480464
G Glul glutamate-ammonia ligase JBrowse link 13 71,331,052 71,340,207 RGD:6480464
G Grb7 growth factor receptor bound protein 7 JBrowse link 10 86,393,186 86,408,893 RGD:6480464
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:6480464
G Hbegf heparin-binding EGF-like growth factor JBrowse link 18 29,330,302 29,340,185 RGD:6480464
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6480464
G Igf2 insulin-like growth factor 2 JBrowse link 1 215,828,102 215,839,081 RGD:6480464
G Igfbp3 insulin-like growth factor binding protein 3 JBrowse link 14 87,457,647 87,465,374 RGD:6480464
G Il10ra interleukin 10 receptor subunit alpha JBrowse link 8 49,558,062 49,573,891 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il24 interleukin 24 JBrowse link 13 47,618,451 47,623,849 RGD:6480464
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:6480464
G Ivl involucrin JBrowse link 2 192,761,171 192,773,346 RGD:6480464
G Krt1 keratin 1 JBrowse link 7 143,448,318 143,453,544 RGD:6480464
G Krt10 keratin 10 JBrowse link 10 87,296,445 87,301,307 RGD:6480464
G Krt14 keratin 14 JBrowse link 10 88,118,029 88,122,233 RGD:6480464
G Krt15 keratin 15 JBrowse link 10 88,046,803 88,050,622 RGD:6480464
G Krt17 keratin 17 JBrowse link 10 88,158,993 88,163,712 RGD:6480464
G Krt18 keratin 18 JBrowse link 7 143,629,455 143,633,131 RGD:6480464
G Krt19 keratin 19 JBrowse link 10 88,055,843 88,060,560 RGD:6480464
G Krt5 keratin 5 JBrowse link 7 143,320,142 143,324,536 RGD:6480464
G Krt7 keratin 7 JBrowse link 7 143,059,731 143,075,907 RGD:6480464
G Krt75 keratin 75 JBrowse link 7 143,219,012 143,228,237 RGD:6480464
G Krt8 keratin 8 JBrowse link 7 143,596,511 143,603,745 RGD:6480464
G Lama2 laminin subunit alpha 2 JBrowse link 1 18,491,264 19,143,486 RGD:6480464
G Lama3 laminin subunit alpha 3 JBrowse link 18 3,704,866 3,941,215 RGD:6480464
G Lamc3 laminin subunit gamma 3 JBrowse link 3 9,265,407 9,327,107 RGD:6480464
G Lcn2 lipocalin 2 JBrowse link 3 11,414,189 11,417,534 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Meis1 Meis homeobox 1 JBrowse link 14 103,182,178 103,321,809 RGD:6480464
G Meis2 Meis homeobox 2 JBrowse link 3 107,560,172 107,762,732 RGD:6480464
G Meox1 mesenchyme homeobox 1 JBrowse link 10 89,797,011 89,817,009 RGD:6480464
G Mfap2 microfibril associated protein 2 JBrowse link 5 159,534,202 159,539,750 RGD:6480464
G Mmp10 matrix metallopeptidase 10 JBrowse link 8 5,734,348 5,742,243 RGD:6480464
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming JBrowse link 1 214,725,482 214,756,653 RGD:6480464
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 JBrowse link 17 22,984,792 23,179,701 RGD:6480464
G Nefl neurofilament light JBrowse link 15 44,799,378 44,803,251 RGD:6480464
G Odc1 ornithine decarboxylase 1 JBrowse link 6 42,852,529 42,859,142 RGD:6480464
G Olr1 oxidized low density lipoprotein receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:6480464
G Pir pirin JBrowse link X 31,852,322 31,968,152 RGD:6480464
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:6480464
G Rarb retinoic acid receptor, beta JBrowse link 15 9,915,223 10,262,599 RGD:6480464
G Rarg retinoic acid receptor, gamma JBrowse link 7 143,840,739 143,863,206 RGD:6480464
G Rarres1 retinoic acid receptor responder 1 JBrowse link 2 164,650,722 164,684,982 RGD:6480464
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6480464
G Rhob ras homolog family member B JBrowse link 6 33,689,127 33,691,301 RGD:6480464
G Rnf5 ring finger protein 5 JBrowse link 20 4,366,244 4,368,690 RGD:6480464
G Rps13 ribosomal protein S13 JBrowse link 1 185,328,902 185,331,332 RGD:6480464
G S100a1 S100 calcium binding protein A1 JBrowse link 2 189,900,505 189,905,348 RGD:6480464
G S100a8 S100 calcium binding protein A8 JBrowse link 2 190,073,239 190,074,333 RGD:6480464
G S100a9 S100 calcium binding protein A9 JBrowse link 2 190,097,436 190,100,209 RGD:6480464
G Serpina3m serine (or cysteine) proteinase inhibitor, clade A, member 3M JBrowse link 6 127,808,785 127,816,067 RGD:6480464
G Serpinb2 serpin family B member 2 JBrowse link 13 27,449,907 27,463,015 RGD:6480464
G Serpinb9 serpin family B member 9 JBrowse link 17 32,648,846 32,673,047 RGD:6480464
G Slc16a1 solute carrier family 16 member 1 JBrowse link 2 207,108,552 207,129,352 RGD:6480464
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:6480464
G Socs2 suppressor of cytokine signaling 2 JBrowse link 7 36,495,496 36,500,878 RGD:6480464
G Sprr1b small proline-rich protein 1B JBrowse link 2 192,622,972 192,624,848 RGD:6480464
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:6480464
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 JBrowse link 1 199,664,039 199,670,970 RGD:6480464
G Tgm1 transglutaminase 1 JBrowse link 15 34,378,136 34,393,150 RGD:6480464
G Tgm2 transglutaminase 2 JBrowse link 3 154,597,165 154,627,257 RGD:6480464
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:6480464
G Tmsb4x thymosin beta 4, X-linked JBrowse link X 28,593,405 28,617,267 RGD:6480464
G Vegfc vascular endothelial growth factor C JBrowse link 16 40,440,371 40,555,178 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      chemical role 19128
        antioxidant 14048
          all-trans-retinoic acid 7250
            all-trans-4-oxoretinoic acid 106
              1-O-(4-oxoretinoyl)-beta-D-glucuronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        monocarboxylic acid 17256
                                          alpha,beta-unsaturated monocarboxylic acid 11261
                                            retinoic acid 7492
                                              all-trans-retinoic acid 7250
                                                all-trans-4-oxoretinoic acid 106
                                                  1-O-(4-oxoretinoyl)-beta-D-glucuronic acid 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.