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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:all-trans-4-oxoretinoic acid
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Accession:CHEBI:80656 term browser browse the term
Definition:A retinoid that consists of all-trans-retinoic acid bearing an oxo substituent at position 4 on the cyclohexenyl ring.
Synonyms:exact_synonym: 4-oxoretinoic acid
 related_synonym: 4-oxo-all-trans-retinoic acid;   4-oxo-atRA;   Formula=C20H26O3;   InChI=1S/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/b8-6+,10-9+,14-7+,15-13+;   InChIKey=GGCUJPCCTQNTJF-FRCNGJHJSA-N;   SMILES=C\\C(\\C=C\\C1=C(C)C(=O)CCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
 xref: CAS:38030-57-8;   HMDB:HMDB0006285;   KEGG:C16678
 xref_mesh: MESH:C002202
 xref: PMID:2051220;   PMID:25492813;   PMID:2772923;   PMID:435468;   Reaxys:2878846


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all-trans-4-oxoretinoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein decreases expression ISO 4-oxoretinoic acid results in decreased expression of AIP mRNA CTD PMID:15982314 NCBI chr 1:201,407,287...201,419,220
Ensembl chr 1:201,407,288...201,419,122
JBrowse link
G Anxa1 annexin A1 increases expression ISO 4-oxoretinoic acid results in increased expression of ANXA1 mRNA CTD PMID:15982314 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Apod apolipoprotein D increases expression ISO 4-oxoretinoic acid results in increased expression of APOD mRNA CTD PMID:15982314 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
JBrowse link
G Cbx3 chromobox 3 decreases expression ISO 4-oxoretinoic acid results in decreased expression of CBX3 mRNA CTD PMID:15982314 NCBI chr 4:80,545,450...80,559,284
Ensembl chr 4:80,546,010...80,559,283
JBrowse link
G Cdh1 cadherin 1 affects expression ISO 4-oxoretinoic acid affects the expression of CDH1 mRNA CTD PMID:17034753 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO 4-oxoretinoic acid results in increased expression of CDKN1C mRNA CTD PMID:15982314 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
JBrowse link
G Ckb creatine kinase B decreases expression ISO 4-oxoretinoic acid results in decreased expression of CKB mRNA CTD PMID:15982314 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO 4-oxoretinoic acid results in increased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col4a2 collagen type IV alpha 2 chain increases expression ISO 4-oxoretinoic acid results in increased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
JBrowse link
G Col6a1 collagen type VI alpha 1 chain decreases expression ISO 4-oxoretinoic acid results in decreased expression of COL6A1 mRNA CTD PMID:15982314 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Col8a2 collagen type VIII alpha 2 chain decreases expression ISO 4-oxoretinoic acid results in decreased expression of COL8A2 mRNA CTD PMID:15982314 NCBI chr 5:138,586,201...138,613,627
Ensembl chr 5:138,585,999...138,612,850
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 increases expression ISO 4-oxoretinoic acid results in increased expression of CRABP2 mRNA CTD PMID:17034753 NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of CXCL1 mRNA CTD PMID:15982314 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO 4-oxoretinoic acid results in decreased expression of CXCL1 mRNA CTD PMID:15982314 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases chemical synthesis ISO CYP1A1 protein results in increased chemical synthesis of 4-oxoretinoic acid CTD PMID:10874126 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression
multiple interactions
increases metabolic processing
increases chemical synthesis
ISO 4-oxoretinoic acid results in increased expression of CYP26A1 mRNA
[[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; [R 115866 results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid]
CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid; CYP26A1 protein results in increased metabolism of 4-oxoretinoic acid
CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid; CYP26A1 protein results in increased chemical synthesis of 4-oxoretinoic acid
CTD PMID:12091498 PMID:17460545 PMID:25492813 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of CYP27A1 mRNA CTD PMID:15982314 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases chemical synthesis ISO CYP2C8 protein results in increased chemical synthesis of 4-oxoretinoic acid CTD PMID:10874126
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis ISO CYP3A4 protein results in increased chemical synthesis of 4-oxoretinoic acid CTD PMID:10874126 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dsc1 desmocollin 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of DSC1 mRNA CTD PMID:15982314 NCBI chr18:11,499,936...11,556,801
Ensembl chr18:11,502,003...11,528,494
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO 4-oxoretinoic acid results in increased expression of DUSP10 mRNA CTD PMID:15982314 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
JBrowse link
G Dusp11 dual specificity phosphatase 11 decreases expression ISO 4-oxoretinoic acid results in decreased expression of DUSP11 mRNA CTD PMID:15982314 NCBI chr 4:118,367,673...118,385,183
Ensembl chr 4:118,368,053...118,385,181
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of E2F1 mRNA CTD PMID:15982314 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO 4-oxoretinoic acid results in decreased expression of EGFR mRNA CTD PMID:15982314 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of EIF4EBP2 mRNA CTD PMID:15982314 NCBI chr20:29,379,444...29,400,131
Ensembl chr20:29,382,668...29,399,946
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO 4-oxoretinoic acid results in increased expression of EMP1 mRNA CTD PMID:15982314 NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904
JBrowse link
G Fabp5 fatty acid binding protein 5 decreases expression ISO 4-oxoretinoic acid results in decreased expression of FABP5 mRNA CTD PMID:15982314 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Fam3c FAM3 metabolism regulating signaling molecule C increases expression ISO 4-oxoretinoic acid results in increased expression of FAM3C mRNA CTD PMID:15982314 NCBI chr 4:50,839,929...50,887,276
Ensembl chr 4:50,838,818...50,888,078
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO 4-oxoretinoic acid results in decreased expression of FAS mRNA CTD PMID:17034753 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fasn fatty acid synthase increases expression ISO 4-oxoretinoic acid results in increased expression of FASN mRNA CTD PMID:15982314 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fastk Fas-activated serine/threonine kinase decreases expression ISO 4-oxoretinoic acid results in decreased expression of FASTK mRNA CTD PMID:15982314 NCBI chr 4:10,732,273...10,736,332
Ensembl chr 4:10,732,256...10,737,430
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of FGF1 mRNA CTD PMID:15982314 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fkbp8 FKBP prolyl isomerase 8 increases expression ISO 4-oxoretinoic acid results in increased expression of FKBP8 mRNA CTD PMID:15982314 NCBI chr16:18,895,608...18,902,648
Ensembl chr16:18,893,576...18,902,612
JBrowse link
G Flg filaggrin decreases expression ISO 4-oxoretinoic acid results in decreased expression of FLG mRNA CTD PMID:15982314 NCBI chr 2:178,888,688...178,912,731 JBrowse link
G Foxa1 forkhead box A1 increases expression ISO 4-oxoretinoic acid results in increased expression of FOXA1 mRNA CTD PMID:17034753 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO 4-oxoretinoic acid results in increased expression of G6PD mRNA CTD PMID:15982314 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO 4-oxoretinoic acid results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Gba glucosylceramidase beta decreases expression ISO 4-oxoretinoic acid results in decreased expression of GBA mRNA CTD PMID:15982314 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO 4-oxoretinoic acid results in increased expression of GDF15 mRNA CTD PMID:15982314 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gdf2 growth differentiation factor 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of GDF2 mRNA CTD PMID:15982314 NCBI chr16:9,255,430...9,261,429
Ensembl chr16:9,255,430...9,261,429
JBrowse link
G Glul glutamate-ammonia ligase increases expression ISO 4-oxoretinoic acid results in increased expression of GLUL mRNA CTD PMID:15982314 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Grb7 growth factor receptor bound protein 7 decreases expression ISO 4-oxoretinoic acid results in decreased expression of GRB7 mRNA CTD PMID:15982314 NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of GSTM1 mRNA CTD PMID:15982314 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO 4-oxoretinoic acid results in increased expression of HBEGF mRNA CTD PMID:15982314 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO 4-oxoretinoic acid results in increased expression of IGF1 mRNA CTD PMID:15982314 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf2 insulin-like growth factor 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of IGF2 mRNA CTD PMID:15982314 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression ISO 4-oxoretinoic acid results in increased expression of IGFBP3 mRNA CTD PMID:15982314 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha decreases expression ISO 4-oxoretinoic acid results in decreased expression of IL10RA mRNA CTD PMID:15982314 NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
JBrowse link
G Il1b interleukin 1 beta increases expression ISO 4-oxoretinoic acid results in increased expression of IL1B mRNA CTD PMID:15982314 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 decreases expression ISO 4-oxoretinoic acid results in decreased expression of IL24 mRNA CTD PMID:15982314 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Itga4 integrin subunit alpha 4 increases expression ISO 4-oxoretinoic acid results in increased expression of ITGA4 mRNA CTD PMID:15982314 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
JBrowse link
G Ivl involucrin increases expression ISO 4-oxoretinoic acid results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
JBrowse link
G Krt1 keratin 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT1 mRNA CTD PMID:15982314 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
JBrowse link
G Krt10 keratin 10 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT10 mRNA CTD PMID:15982314 NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
JBrowse link
G Krt14 keratin 14 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT14 mRNA CTD PMID:15982314 NCBI chr10:85,137,932...85,141,990
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Krt15 keratin 15 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT15 mRNA CTD PMID:15982314 NCBI chr10:85,066,797...85,070,614 JBrowse link
G Krt17 keratin 17 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT17 mRNA CTD PMID:15982314 NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392
JBrowse link
G Krt18 keratin 18 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT18 mRNA CTD PMID:17034753 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Krt19 keratin 19 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT19 mRNA; 4-oxoretinoic acid results in increased expression of KRT19 protein CTD PMID:15982314 PMID:17034753 NCBI chr10:85,075,835...85,080,552 JBrowse link
G Krt5 keratin 5 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT5 mRNA CTD PMID:15982314 NCBI chr 7:132,846,355...132,851,986
Ensembl chr 7:132,846,136...132,851,850
JBrowse link
G Krt6a keratin 6A decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT6A mRNA CTD PMID:15982314 NCBI chr 7:132,829,278...132,833,665 JBrowse link
G Krt7 keratin 7 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT7 mRNA; 4-oxoretinoic acid results in increased expression of KRT7 protein CTD PMID:15982314 PMID:17034753 NCBI chr 7:132,528,863...132,545,052
Ensembl chr 7:132,528,895...132,545,052
JBrowse link
G Krt75 keratin 75 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT75 mRNA CTD PMID:15982314 NCBI chr 7:132,687,101...132,697,360
Ensembl chr 7:132,688,237...132,697,345
JBrowse link
G Krt8 keratin 8 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT8 mRNA CTD PMID:17034753 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lama2 laminin subunit alpha 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of LAMA2 mRNA CTD PMID:15982314 NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530
JBrowse link
G Lama3 laminin subunit alpha 3 decreases expression ISO 4-oxoretinoic acid results in decreased expression of LAMA3 mRNA CTD PMID:15982314 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353
JBrowse link
G Lamc3 laminin subunit gamma 3 increases expression ISO 4-oxoretinoic acid results in increased expression of LAMC3 mRNA CTD PMID:15982314 NCBI chr 3:15,165,220...15,226,697
Ensembl chr 3:15,165,220...15,226,697
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO 4-oxoretinoic acid results in increased expression of LCN2 mRNA CTD PMID:15982314 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO 4-oxoretinoic acid results in decreased expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Meis1 Meis homeobox 1 increases expression ISO 4-oxoretinoic acid results in increased expression of MEIS1 mRNA CTD PMID:17034753 NCBI chr14:93,155,426...93,294,373
Ensembl chr14:93,155,419...93,294,265
JBrowse link
G Meis2 Meis homeobox 2 increases expression ISO 4-oxoretinoic acid results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr 3:102,742,905...102,944,833
Ensembl chr 3:102,742,900...102,949,696
JBrowse link
G Meox1 mesenchyme homeobox 1 increases expression ISO 4-oxoretinoic acid results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660
JBrowse link
G Mfap2 microfibril associated protein 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of MFAP2 mRNA CTD PMID:15982314 NCBI chr 5:153,312,068...153,320,266
Ensembl chr 5:153,314,711...153,320,259
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO 4-oxoretinoic acid results in decreased expression of MMP10 mRNA CTD PMID:15982314 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression ISO 4-oxoretinoic acid results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO 4-oxoretinoic acid results in increased expression of NEDD9 mRNA CTD PMID:15982314 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
JBrowse link
G Nefl neurofilament light chain decreases expression ISO 4-oxoretinoic acid results in decreased expression of NEFL mRNA CTD PMID:15982314 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of ODC1 mRNA CTD PMID:15982314 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO 4-oxoretinoic acid results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Pir pirin increases expression ISO 4-oxoretinoic acid results in increased expression of PIR mRNA CTD PMID:15982314 NCBI chr  X:30,108,536...30,219,269
Ensembl chr  X:30,108,538...30,219,218
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO 4-oxoretinoic acid results in increased expression of PLAT mRNA CTD PMID:15982314 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of PTGS1 mRNA CTD PMID:15982314 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of PTGS2 mRNA CTD PMID:15982314 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rara retinoic acid receptor, alpha increases expression
increases activity
ISO 4-oxoretinoic acid results in increased expression of RARA mRNA
4-oxoretinoic acid results in increased activity of RARA protein
CTD PMID:17034753 PMID:25492813 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rarb retinoic acid receptor, beta increases activity
increases expression
ISO 4-oxoretinoic acid results in increased activity of RARB protein
4-oxoretinoic acid results in increased expression of RARB mRNA
CTD PMID:17034753 PMID:25492813 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rarg retinoic acid receptor, gamma increases activity
multiple interactions
ISO 4-oxoretinoic acid results in increased activity of RARG protein
4-oxoretinoic acid results in increased activity of [RARG protein binds to RXRA protein]
CTD PMID:25492813 PMID:30639747 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression ISO 4-oxoretinoic acid results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO 4-oxoretinoic acid results in decreased expression of RHOA mRNA CTD PMID:15982314 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhob ras homolog family member B decreases expression ISO 4-oxoretinoic acid results in decreased expression of RHOB mRNA CTD PMID:15982314 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Rnf5 ring finger protein 5 decreases expression ISO 4-oxoretinoic acid results in decreased expression of RNF5 mRNA CTD PMID:15982314 NCBI chr20:4,145,539...4,147,985
Ensembl chr20:4,145,507...4,147,985
JBrowse link
G Rps13 ribosomal protein S13 increases expression ISO 4-oxoretinoic acid results in increased expression of RPS13 mRNA CTD PMID:15982314 NCBI chr 1:170,572,925...170,575,355
Ensembl chr 1:170,572,921...170,575,355
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO 4-oxoretinoic acid results in increased activity of [RARG protein binds to RXRA protein] CTD PMID:30639747 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G S100a1 S100 calcium binding protein A1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of S100A1 mRNA CTD PMID:15982314 NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO 4-oxoretinoic acid results in increased expression of S100A8 mRNA CTD PMID:15982314 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO 4-oxoretinoic acid results in increased expression of S100A9 mRNA CTD PMID:15982314 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression ISO 4-oxoretinoic acid results in increased expression of SERPINA3 mRNA CTD PMID:15982314 NCBI chr 6:123,323,632...123,331,166 JBrowse link
G Serpinb2 serpin family B member 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SERPINB2 mRNA CTD PMID:15982314 NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
JBrowse link
G Serpinb9 serpin family B member 9 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SERPINB9 mRNA CTD PMID:15982314 NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230
JBrowse link
G Slc16a1 solute carrier family 16 member 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SLC16A1 mRNA CTD PMID:15982314 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Socs1 suppressor of cytokine signaling 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SOCS1 mRNA CTD PMID:15982314 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Socs2 suppressor of cytokine signaling 2 increases expression ISO 4-oxoretinoic acid results in increased expression of SOCS2 mRNA CTD PMID:15982314 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
JBrowse link
G Sprr1b small proline-rich protein 1B decreases expression ISO 4-oxoretinoic acid results in decreased expression of SPRR1B mRNA CTD PMID:15982314 NCBI chr 2:178,009,130...178,009,567
Ensembl chr 2:178,009,130...178,009,567
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SULT2A1 mRNA CTD PMID:15982314 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 increases expression ISO 4-oxoretinoic acid results in increased expression of TGFB1I1 mRNA CTD PMID:15982314 NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080
JBrowse link
G Tgm1 transglutaminase 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of TGM1 mRNA CTD PMID:15982314 NCBI chr15:29,191,039...29,206,000
Ensembl chr15:29,191,041...29,204,523
JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO 4-oxoretinoic acid results in increased expression of TGM2 mRNA CTD PMID:17034753 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Thbs1 thrombospondin 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of THBS1 mRNA CTD PMID:15982314 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Tmsb4x thymosin beta 4, X-linked increases expression ISO 4-oxoretinoic acid results in increased expression of TMSB4X mRNA CTD PMID:15982314 NCBI chr  X:27,144,677...27,146,667
Ensembl chr  X:27,128,610...27,146,667
JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression ISO 4-oxoretinoic acid results in decreased expression of VEGFC mRNA CTD PMID:15982314 NCBI chr16:37,712,408...37,827,657
Ensembl chr16:37,712,262...37,827,848
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      chemical role 19345
        antioxidant 14443
          all-trans-retinoic acid 7419
            all-trans-4-oxoretinoic acid 109
              1-O-(4-oxoretinoyl)-beta-D-glucuronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          alpha,beta-unsaturated monocarboxylic acid 12219
                                            retinoic acid 7680
                                              all-trans-retinoic acid 7419
                                                all-trans-4-oxoretinoic acid 109
                                                  1-O-(4-oxoretinoyl)-beta-D-glucuronic acid 0
paths to the root