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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:all-trans-4-oxoretinoic acid
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Accession:CHEBI:80656 term browser browse the term
Definition:A retinoid that consists of all-trans-retinoic acid bearing an oxo substituent at position 4 on the cyclohexenyl ring.
Synonyms:exact_synonym: 4-oxoretinoic acid
 related_synonym: 4-oxo-all-trans-retinoic acid;   4-oxo-atRA;   Formula=C20H26O3;   InChI=1S/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/b8-6+,10-9+,14-7+,15-13+;   InChIKey=GGCUJPCCTQNTJF-FRCNGJHJSA-N;   SMILES=C\\C(\\C=C\\C1=C(C)C(=O)CCC1(C)C)=C/C=C/C(/C)=C/C(O)=O
 xref: CAS:38030-57-8;   HMDB:HMDB0006285;   KEGG:C16678
 xref_mesh: MESH:C002202
 xref: PMID:2051220;   PMID:25492813;   PMID:2772923;   PMID:435468;   Reaxys:2878846


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all-trans-4-oxoretinoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein decreases expression ISO 4-oxoretinoic acid results in decreased expression of AIP mRNA CTD PMID:15982314 NCBI chr 1:219,361,859...219,373,924
Ensembl chr 1:219,361,860...219,374,014
JBrowse link
G Anxa1 annexin A1 increases expression ISO 4-oxoretinoic acid results in increased expression of ANXA1 mRNA CTD PMID:15982314 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Apod apolipoprotein D increases expression ISO 4-oxoretinoic acid results in increased expression of APOD mRNA CTD PMID:15982314 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G Cbx3 chromobox 3 decreases expression ISO 4-oxoretinoic acid results in decreased expression of CBX3 mRNA CTD PMID:15982314 NCBI chr 4:81,243,809...81,257,898
Ensembl chr 4:81,244,469...81,257,897
JBrowse link
G Cdh1 cadherin 1 affects expression ISO 4-oxoretinoic acid affects the expression of CDH1 mRNA CTD PMID:17034753 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO 4-oxoretinoic acid results in increased expression of CDKN1C mRNA CTD PMID:15982314 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Ckb creatine kinase B decreases expression ISO 4-oxoretinoic acid results in decreased expression of CKB mRNA CTD PMID:15982314 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO 4-oxoretinoic acid results in increased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col4a2 collagen type IV alpha 2 chain increases expression ISO 4-oxoretinoic acid results in increased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr16:83,386,388...83,522,169
Ensembl chr16:83,387,364...83,438,561
JBrowse link
G Col6a1 collagen type VI alpha 1 chain decreases expression ISO 4-oxoretinoic acid results in decreased expression of COL6A1 mRNA CTD PMID:15982314 NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561
JBrowse link
G Col8a2 collagen type VIII alpha 2 chain decreases expression ISO 4-oxoretinoic acid results in decreased expression of COL8A2 mRNA CTD PMID:15982314 NCBI chr 5:144,308,527...144,335,142
Ensembl chr 5:144,308,611...144,335,172
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 increases expression ISO 4-oxoretinoic acid results in increased expression of CRABP2 mRNA CTD PMID:17034753 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of CXCL1 mRNA CTD PMID:15982314 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO 4-oxoretinoic acid results in decreased expression of CXCL1 mRNA CTD PMID:15982314 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases chemical synthesis ISO CYP1A1 protein results in increased chemical synthesis of 4-oxoretinoic acid CTD PMID:10874126 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression
multiple interactions
increases metabolic processing
increases chemical synthesis
ISO 4-oxoretinoic acid results in increased expression of CYP26A1 mRNA
[[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [[R 115866 results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; [R 115866 results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid]
CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid; CYP26A1 protein results in increased metabolism of 4-oxoretinoic acid
CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid; CYP26A1 protein results in increased chemical synthesis of 4-oxoretinoic acid
CTD PMID:12091498, PMID:17460545, PMID:25492813 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of CYP27A1 mRNA CTD PMID:15982314 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases chemical synthesis ISO CYP2C8 protein results in increased chemical synthesis of 4-oxoretinoic acid CTD PMID:10874126 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Dsc1 desmocollin 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of DSC1 mRNA CTD PMID:15982314 NCBI chr18:11,877,918...11,906,828
Ensembl chr18:11,877,561...11,906,827
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO 4-oxoretinoic acid results in increased expression of DUSP10 mRNA CTD PMID:15982314 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Dusp11 dual specificity phosphatase 11 decreases expression ISO 4-oxoretinoic acid results in decreased expression of DUSP11 mRNA CTD PMID:15982314 NCBI chr 4:117,617,640...117,631,674
Ensembl chr 4:117,617,533...117,631,716
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of E2F1 mRNA CTD PMID:15982314 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO 4-oxoretinoic acid results in decreased expression of EGFR mRNA CTD PMID:15982314 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of EIF4EBP2 mRNA CTD PMID:15982314 NCBI chr20:31,055,292...31,072,469
Ensembl chr20:31,055,789...31,072,469
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO 4-oxoretinoic acid results in increased expression of EMP1 mRNA CTD PMID:15982314 NCBI chr 4:169,161,076...169,181,967
Ensembl chr 4:169,147,243...169,181,966
JBrowse link
G Fabp5 fatty acid binding protein 5 decreases expression ISO 4-oxoretinoic acid results in decreased expression of FABP5 mRNA CTD PMID:15982314 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378
JBrowse link
G Fam3c FAM3 metabolism regulating signaling molecule C increases expression ISO 4-oxoretinoic acid results in increased expression of FAM3C mRNA CTD PMID:15982314 NCBI chr 4:49,388,962...49,439,892
Ensembl chr 4:49,387,989...49,439,867
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO 4-oxoretinoic acid results in decreased expression of FAS mRNA CTD PMID:17034753 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fasn fatty acid synthase increases expression ISO 4-oxoretinoic acid results in increased expression of FASN mRNA CTD PMID:15982314 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fastk Fas-activated serine/threonine kinase decreases expression ISO 4-oxoretinoic acid results in decreased expression of FASTK mRNA CTD PMID:15982314 NCBI chr 4:7,260,521...7,264,590
Ensembl chr 4:7,260,575...7,264,589
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of FGF1 mRNA CTD PMID:15982314 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fkbp8 FKBP prolyl isomerase 8 increases expression ISO 4-oxoretinoic acid results in increased expression of FKBP8 mRNA CTD PMID:15982314 NCBI chr16:20,645,956...20,652,890
Ensembl chr16:20,645,957...20,652,889
JBrowse link
G Flg filaggrin decreases expression ISO 4-oxoretinoic acid results in decreased expression of FLG mRNA CTD PMID:15982314 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Foxa1 forkhead box A1 increases expression ISO 4-oxoretinoic acid results in increased expression of FOXA1 mRNA CTD PMID:17034753 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO 4-oxoretinoic acid results in increased expression of G6PD mRNA CTD PMID:15982314 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO 4-oxoretinoic acid results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Gba glucosylceramidase beta decreases expression ISO 4-oxoretinoic acid results in decreased expression of GBA mRNA CTD PMID:15982314 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO 4-oxoretinoic acid results in increased expression of GDF15 mRNA CTD PMID:15982314 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gdf2 growth differentiation factor 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of GDF2 mRNA CTD PMID:15982314 NCBI chr16:10,267,510...10,293,545
Ensembl chr16:10,267,482...10,273,239
JBrowse link
G Glul glutamate-ammonia ligase increases expression ISO 4-oxoretinoic acid results in increased expression of GLUL mRNA CTD PMID:15982314 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Grb7 growth factor receptor bound protein 7 decreases expression ISO 4-oxoretinoic acid results in decreased expression of GRB7 mRNA CTD PMID:15982314 NCBI chr10:86,393,186...86,408,893
Ensembl chr10:86,399,827...86,409,348
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of GSTM1 mRNA CTD PMID:15982314 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO 4-oxoretinoic acid results in increased expression of HBEGF mRNA CTD PMID:15982314 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO 4-oxoretinoic acid results in increased expression of IGF1 mRNA CTD PMID:15982314 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf2 insulin-like growth factor 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of IGF2 mRNA CTD PMID:15982314 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression ISO 4-oxoretinoic acid results in increased expression of IGFBP3 mRNA CTD PMID:15982314 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha decreases expression ISO 4-oxoretinoic acid results in decreased expression of IL10RA mRNA CTD PMID:15982314 NCBI chr 8:49,558,062...49,573,891
Ensembl chr 8:49,560,035...49,573,742
JBrowse link
G Il1b interleukin 1 beta increases expression ISO 4-oxoretinoic acid results in increased expression of IL1B mRNA CTD PMID:15982314 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il24 interleukin 24 decreases expression ISO 4-oxoretinoic acid results in decreased expression of IL24 mRNA CTD PMID:15982314 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Itga4 integrin subunit alpha 4 increases expression ISO 4-oxoretinoic acid results in increased expression of ITGA4 mRNA CTD PMID:15982314 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
G Ivl involucrin increases expression ISO 4-oxoretinoic acid results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577
JBrowse link
G Krt1 keratin 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT1 mRNA CTD PMID:15982314 NCBI chr 7:143,448,318...143,453,544
Ensembl chr 7:143,448,318...143,453,544
JBrowse link
G Krt10 keratin 10 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT10 mRNA CTD PMID:15982314 NCBI chr10:87,296,445...87,301,307
Ensembl chr10:87,296,451...87,300,736
JBrowse link
G Krt14 keratin 14 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT14 mRNA CTD PMID:15982314 NCBI chr10:88,118,029...88,122,233
Ensembl chr10:88,055,823...88,122,233
JBrowse link
G Krt15 keratin 15 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT15 mRNA CTD PMID:15982314 NCBI chr10:88,046,803...88,050,622
Ensembl chr10:88,046,803...88,050,622
JBrowse link
G Krt17 keratin 17 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT17 mRNA CTD PMID:15982314 NCBI chr10:88,158,993...88,163,712
Ensembl chr10:88,118,001...88,163,723
JBrowse link
G Krt18 keratin 18 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT18 mRNA CTD PMID:17034753 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt19 keratin 19 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT19 mRNA; 4-oxoretinoic acid results in increased expression of KRT19 protein CTD PMID:15982314, PMID:17034753 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Krt5 keratin 5 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT5 mRNA CTD PMID:15982314 NCBI chr 7:143,320,142...143,324,536
Ensembl chr 7:143,316,920...143,453,546
JBrowse link
G Krt7 keratin 7 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT7 mRNA; 4-oxoretinoic acid results in increased expression of KRT7 protein CTD PMID:15982314, PMID:17034753 NCBI chr 7:143,059,731...143,075,907
Ensembl chr 7:143,059,764...143,075,907
JBrowse link
G Krt75 keratin 75 decreases expression ISO 4-oxoretinoic acid results in decreased expression of KRT75 mRNA CTD PMID:15982314 NCBI chr 7:143,219,012...143,228,237
Ensembl chr 7:143,219,012...143,228,060
JBrowse link
G Krt8 keratin 8 increases expression ISO 4-oxoretinoic acid results in increased expression of KRT8 mRNA CTD PMID:17034753 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lama2 laminin subunit alpha 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of LAMA2 mRNA CTD PMID:15982314 NCBI chr 1:18,491,264...19,143,486
Ensembl chr 1:18,491,384...19,143,269
JBrowse link
G Lama3 laminin subunit alpha 3 decreases expression ISO 4-oxoretinoic acid results in decreased expression of LAMA3 mRNA CTD PMID:15982314 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838
JBrowse link
G Lamc3 laminin subunit gamma 3 increases expression ISO 4-oxoretinoic acid results in increased expression of LAMC3 mRNA CTD PMID:15982314 NCBI chr 3:9,265,407...9,327,107
Ensembl chr 3:9,267,122...9,326,993
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO 4-oxoretinoic acid results in increased expression of LCN2 mRNA CTD PMID:15982314 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO 4-oxoretinoic acid results in decreased expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Meis1 Meis homeobox 1 increases expression ISO 4-oxoretinoic acid results in increased expression of MEIS1 mRNA CTD PMID:17034753 NCBI chr14:103,182,178...103,321,809
Ensembl chr14:103,181,281...103,321,270
JBrowse link
G Meis2 Meis homeobox 2 increases expression ISO 4-oxoretinoic acid results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr 3:107,560,172...107,762,732
Ensembl chr 3:107,559,997...107,760,589
JBrowse link
G Meox1 mesenchyme homeobox 1 increases expression ISO 4-oxoretinoic acid results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491
JBrowse link
G Mfap2 microfibril associated protein 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of MFAP2 mRNA CTD PMID:15982314 NCBI chr 5:159,534,202...159,539,750
Ensembl chr 5:159,534,202...159,539,750
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO 4-oxoretinoic acid results in decreased expression of MMP10 mRNA CTD PMID:15982314 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression ISO 4-oxoretinoic acid results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO 4-oxoretinoic acid results in increased expression of NEDD9 mRNA CTD PMID:15982314 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Nefl neurofilament light decreases expression ISO 4-oxoretinoic acid results in decreased expression of NEFL mRNA CTD PMID:15982314 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of ODC1 mRNA CTD PMID:15982314 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO 4-oxoretinoic acid results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Pir pirin increases expression ISO 4-oxoretinoic acid results in increased expression of PIR mRNA CTD PMID:15982314 NCBI chr  X:31,852,322...31,968,152
Ensembl chr  X:31,852,323...31,968,152
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO 4-oxoretinoic acid results in increased expression of PLAT mRNA CTD PMID:15982314 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of PTGS1 mRNA CTD PMID:15982314 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of PTGS2 mRNA CTD PMID:15982314 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rara retinoic acid receptor, alpha increases expression
increases activity
ISO 4-oxoretinoic acid results in increased expression of RARA mRNA
4-oxoretinoic acid results in increased activity of RARA protein
CTD PMID:17034753, PMID:25492813 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rarb retinoic acid receptor, beta increases activity
increases expression
ISO 4-oxoretinoic acid results in increased activity of RARB protein
4-oxoretinoic acid results in increased expression of RARB mRNA
CTD PMID:17034753, PMID:25492813 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rarg retinoic acid receptor, gamma increases activity ISO 4-oxoretinoic acid results in increased activity of RARG protein CTD PMID:25492813 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186
JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression ISO 4-oxoretinoic acid results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 2:164,650,722...164,684,982
Ensembl chr 2:164,650,722...164,684,985
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO 4-oxoretinoic acid results in decreased expression of RHOA mRNA CTD PMID:15982314 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rhob ras homolog family member B decreases expression ISO 4-oxoretinoic acid results in decreased expression of RHOB mRNA CTD PMID:15982314 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Rnf5 ring finger protein 5 decreases expression ISO 4-oxoretinoic acid results in decreased expression of RNF5 mRNA CTD PMID:15982314 NCBI chr20:4,366,244...4,368,690
Ensembl chr20:4,366,246...4,368,693
JBrowse link
G Rps13 ribosomal protein S13 increases expression ISO 4-oxoretinoic acid results in increased expression of RPS13 mRNA CTD PMID:15982314 NCBI chr 1:185,328,902...185,331,332
Ensembl chr 3:4,341,249...4,341,771
JBrowse link
G S100a1 S100 calcium binding protein A1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of S100A1 mRNA CTD PMID:15982314 NCBI chr 2:189,900,505...189,905,348
Ensembl chr 2:189,900,667...189,903,219
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO 4-oxoretinoic acid results in increased expression of S100A8 mRNA CTD PMID:15982314 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO 4-oxoretinoic acid results in increased expression of S100A9 mRNA CTD PMID:15982314 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO 4-oxoretinoic acid results in increased expression of SERPINA3 mRNA CTD PMID:15982314 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Serpinb2 serpin family B member 2 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SERPINB2 mRNA CTD PMID:15982314 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010
JBrowse link
G Serpinb9 serpin family B member 9 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SERPINB9 mRNA CTD PMID:15982314 NCBI chr17:32,648,846...32,673,047
Ensembl chr17:32,650,441...32,661,865
JBrowse link
G Slc16a1 solute carrier family 16 member 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SLC16A1 mRNA CTD PMID:15982314 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Socs1 suppressor of cytokine signaling 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SOCS1 mRNA CTD PMID:15982314 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Socs2 suppressor of cytokine signaling 2 increases expression ISO 4-oxoretinoic acid results in increased expression of SOCS2 mRNA CTD PMID:15982314 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Sprr1b small proline-rich protein 1B decreases expression ISO 4-oxoretinoic acid results in decreased expression of SPRR1B mRNA CTD PMID:15982314 NCBI chr 2:192,622,972...192,624,848
Ensembl chr 2:192,623,244...192,623,681
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of SULT2A1 mRNA CTD PMID:15982314 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 increases expression ISO 4-oxoretinoic acid results in increased expression of TGFB1I1 mRNA CTD PMID:15982314 NCBI chr 1:199,664,039...199,670,970
Ensembl chr 1:199,664,173...199,670,961
JBrowse link
G Tgm1 transglutaminase 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of TGM1 mRNA CTD PMID:15982314 NCBI chr15:34,378,136...34,393,150
Ensembl chr15:34,378,148...34,392,066
JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO 4-oxoretinoic acid results in increased expression of TGM2 mRNA CTD PMID:17034753 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Thbs1 thrombospondin 1 decreases expression ISO 4-oxoretinoic acid results in decreased expression of THBS1 mRNA CTD PMID:15982314 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tmsb4x thymosin beta 4, X-linked increases expression ISO 4-oxoretinoic acid results in increased expression of TMSB4X mRNA CTD PMID:15982314 NCBI chr  X:28,593,405...28,617,267
Ensembl chr  X:28,593,405...28,595,395
JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression ISO 4-oxoretinoic acid results in decreased expression of VEGFC mRNA CTD PMID:15982314 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      chemical role 19248
        antioxidant 14209
          all-trans-retinoic acid 7390
            all-trans-4-oxoretinoic acid 106
              1-O-(4-oxoretinoyl)-beta-D-glucuronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          alpha,beta-unsaturated monocarboxylic acid 11359
                                            retinoic acid 7652
                                              all-trans-retinoic acid 7390
                                                all-trans-4-oxoretinoic acid 106
                                                  1-O-(4-oxoretinoyl)-beta-D-glucuronic acid 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.