Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:irinotecan
go back to main search page
Accession:CHEBI:80630 term browser browse the term
Definition:A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
Synonyms:exact_synonym: (4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate
 related_synonym: Formula=C33H38N4O6;   HSDB 7607;   InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1;   InChIKey=UWKQSNNFCGGAFS-XIFFEERXSA-N;   Irinophore C;   Irinotecan lactone;   Irinotecan mylan;   SMILES=C1(=CC=C2C(=C1)C(=C3C(=N2)C=4N(C3)C(C5=C(C4)[C@](C(OC5)=O)(CC)O)=O)CC)OC(=O)N6CCC(CC6)N7CCCCC7;   irinotecanum
 xref: CAS:97682-44-5;   DrugBank:DB00762;   Drug_Central:1482;   HMDB:HMDB0014900;   KEGG:C16641;   KEGG:D08086;   LINCS:LSM-2167
 xref_mesh: MESH:D000077146
 xref: PDBeChem:CP0;   PMID:26081596;   PMID:26352218;   PMID:26381420;   PMID:26487578;   PMID:26503200;   PMID:26526067;   PMID:26541586;   PMID:26574999;   PMID:26580826;   PMID:26739304;   Reaxys:4839096;   Wikipedia:Irinotecan
 cyclic_relationship: is_conjugate_base_of CHEBI:90895


show annotations for term's descendants           Sort by:
 
irinotecan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP Irinotecan results in increased expression of A2M mRNA CTD PMID:20097248 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects metabolic processing
affects export
affects response to substance
affects expression
decreases response to substance
ISO
EXP
ABCB1 exon SNP affects the susceptibility to and affects the metabolism of Irinotecan
ABCB1A protein affects the metabolism of Irinotecan
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCB1A protein affects the metabolism of Irinotecan]; Everolimus inhibits the reaction [ABCB1A protein affects the metabolism of Irinotecan]
ABCB1 protein affects the export of Irinotecan
ABCB1 gene polymorphism affects the susceptibility to Irinotecan
Irinotecan affects the expression of ABCB1A mRNA
ABCB1 protein results in decreased susceptibility to Irinotecan
CTD PMID:12960109, PMID:15655543, PMID:15801936, PMID:16815871, PMID:20097248, PMID:24727322 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects metabolic processing
multiple interactions
ISO ABCB1B protein affects the metabolism of Irinotecan
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCB1B protein affects the metabolism of Irinotecan]; Everolimus inhibits the reaction [ABCB1B protein affects the metabolism of Irinotecan]
CTD PMID:24727322 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance
decreases expression
multiple interactions
ISO ABCC1 protein results in decreased susceptibility to Irinotecan
Irinotecan analog results in decreased expression of ABCC1 mRNA
[selenomethylselenocysteine co-treated with Irinotecan] results in decreased expression of ABCC1
CTD PMID:15897249, PMID:16815871, PMID:18927307 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects response to substance
decreases response to substance
ISO ABCC2 gene polymorphism affects the susceptibility to Irinotecan; ABCC2 gene polymorphism affects the susceptibility to Irinotecan metabolite
ABCC2 protein results in decreased susceptibility to Irinotecan
CTD PMID:16815871, PMID:18981587 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects export ISO ABCC4 protein affects the export of Irinotecan CTD PMID:15827327 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
affects metabolic processing
increases transport
increases response to substance
affects response to substance
decreases response to substance
affects export
ISO bis(4-nitrophenyl)phosphate inhibits the reaction [ABCG2 protein affects the metabolism of Irinotecan]; Everolimus inhibits the reaction [ABCG2 protein affects the metabolism of Irinotecan]
ABCG2 protein results in increased transport of Irinotecan
ABCG2 mRNA results in increased susceptibility to Irinotecan; ABCG2 protein results in increased susceptibility to Irinotecan
ABCG2 affects the susceptibility to Irinotecan
ABCG2 gene polymorphism affects the susceptibility to and affects the metabolism of Irinotecan; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of Irinotecan]
ABCG2 protein results in decreased susceptibility to Irinotecan; ABCG2 results in decreased susceptibility to Irinotecan
ABCG2 protein affects the export of Irinotecan
CTD PMID:10606239, PMID:12869632, PMID:15239142, PMID:15655543, PMID:15695404, PMID:15801936, PMID:16542215, PMID:16954373, PMID:24727322 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abhd13 abhydrolase domain containing 13 decreases expression ISO Irinotecan analog results in decreased expression of ABHD13 mRNA CTD PMID:18927307 NCBI chr16:85,315,275...85,330,108
Ensembl chr16:85,315,275...85,330,092
JBrowse link
G Abi2 abl-interactor 2 decreases expression ISO Irinotecan results in decreased expression of ABI2 mRNA CTD PMID:20185912 NCBI chr 9:67,234,612...67,284,504
Ensembl chr 9:67,234,303...67,282,600
JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO Irinotecan analog results in decreased expression of ACACA mRNA CTD PMID:18927307 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 increases response to substance ISO ACAT1 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Ache acetylcholinesterase decreases activity EXP Irinotecan results in decreased activity of ACHE protein CTD PMID:11740913 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
ISO Irinotecan results in increased expression of ACTA2 protein
Silymarin affects the reaction [Irinotecan results in increased expression of ACTA2 protein]
CTD PMID:28454924 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ada adenosine deaminase affects expression EXP Irinotecan affects the expression of ADA mRNA CTD PMID:20097248 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Adam19 ADAM metallopeptidase domain 19 increases expression ISO Irinotecan analog results in increased expression of ADAM19 mRNA CTD PMID:18927307 NCBI chr10:31,146,107...31,240,582
Ensembl chr10:31,146,107...31,240,582
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression EXP Irinotecan results in increased expression of ADAMTS1 mRNA CTD PMID:20097248 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
JBrowse link
G Add3 adducin 3 decreases expression ISO Irinotecan metabolite results in decreased expression of ADD3 mRNA; Irinotecan results in decreased expression of ADD3 mRNA CTD PMID:15956246 NCBI chr 1:273,854,195...273,961,982
Ensembl chr 1:273,854,248...273,961,982
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) affects expression EXP Irinotecan affects the expression of ADH1 mRNA CTD PMID:20097248 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Adi1 acireductone dioxygenase 1 decreases expression ISO Irinotecan analog results in decreased expression of ADI1 mRNA CTD PMID:18927307 NCBI chr 6:47,940,211...47,947,173
Ensembl chr 6:47,940,183...47,947,230
JBrowse link
G Adk adenosine kinase affects expression EXP Irinotecan affects the expression of ADK mRNA CTD PMID:20097248 NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888
JBrowse link
G Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 affects expression EXP Irinotecan affects the expression of AGPAT4 mRNA CTD PMID:20097248 NCBI chr 1:48,716,094...48,826,292
Ensembl chr 1:48,719,633...48,825,364
JBrowse link
G Agt angiotensinogen decreases expression ISO Irinotecan analog results in decreased expression of AGT mRNA CTD PMID:18927307 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahcyl1 adenosylhomocysteinase-like 1 affects expression EXP Irinotecan affects the expression of AHCYL1 mRNA CTD PMID:20097248 NCBI chr 2:210,438,884...210,474,350
Ensembl chr 2:210,438,893...210,473,761
JBrowse link
G Ak2 adenylate kinase 2 increases response to substance ISO AK2 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 5:147,185,474...147,204,050
Ensembl chr 5:147,185,474...147,204,050
JBrowse link
G Akap10 A-kinase anchoring protein 10 decreases expression ISO Irinotecan metabolite results in decreased expression of AKAP10 mRNA; Irinotecan results in decreased expression of AKAP10 mRNA CTD PMID:15956246 NCBI chr10:48,150,902...48,210,074
Ensembl chr10:48,150,902...48,210,074
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression ISO Irinotecan metabolite results in increased expression of ALAS2 mRNA; Irinotecan results in increased expression of ALAS2 mRNA CTD PMID:15956246 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Alb albumin decreases expression ISO Irinotecan analog results in decreased expression of ALB mRNA CTD PMID:18927307 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 decreases expression EXP Irinotecan results in decreased expression of ALDH18A1 mRNA CTD PMID:30012503 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Irinotecan metabolite results in decreased expression of ALDH1A1 mRNA; Irinotecan results in decreased expression of ALDH1A1 mRNA CTD PMID:15956246 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 increases expression ISO Irinotecan analog results in increased expression of AMIGO2 mRNA CTD PMID:18927307 NCBI chr 7:138,704,124...138,707,221
Ensembl chr 7:138,704,126...138,707,221
JBrowse link
G Amy2a3 amylase 2a3 affects expression EXP Irinotecan affects the expression of AMY1A mRNA CTD PMID:20097248 NCBI chr 2:216,373,674...216,382,260
Ensembl chr 2:216,339,154...216,382,260
JBrowse link
G Angptl2 angiopoietin-like 2 multiple interactions ISO ANGPTL2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 3:12,262,822...12,292,665
Ensembl chr 3:12,262,822...12,292,663
JBrowse link
G Ankh ANKH inorganic pyrophosphate transport regulator affects expression EXP Irinotecan affects the expression of ANKH mRNA CTD PMID:20097248 NCBI chr 2:80,131,563...80,256,948
Ensembl chr 2:80,131,563...80,256,954
JBrowse link
G Ankrd17 ankyrin repeat domain 17 decreases expression ISO Irinotecan analog results in decreased expression of ANKRD17 mRNA CTD PMID:18927307 NCBI chr14:19,291,025...19,431,521
Ensembl chr14:19,318,565...19,431,515
JBrowse link
G Ankrd28 ankyrin repeat domain 28 decreases expression ISO Irinotecan analog results in decreased expression of ANKRD28 mRNA CTD PMID:18927307 NCBI chr16:7,816,876...7,879,023
Ensembl chr16:7,818,667...7,928,518
JBrowse link
G Anxa13 annexin A13 decreases expression ISO Irinotecan analog results in decreased expression of ANXA13 mRNA CTD PMID:18927307 NCBI chr 7:98,217,642...98,270,442
Ensembl chr 7:98,217,642...98,270,110
JBrowse link
G Anxa2 annexin A2 increases expression ISO Irinotecan results in increased expression of ANXA2 mRNA CTD PMID:15152939 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Anxa6 annexin A6 increases expression ISO Irinotecan metabolite results in increased expression of ANXA6 mRNA; Irinotecan results in increased expression of ANXA6 mRNA CTD PMID:15956246 NCBI chr10:40,320,581...40,375,605
Ensembl chr10:40,320,581...40,375,605
JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 decreases expression ISO Irinotecan analog results in decreased expression of AP2B1 mRNA CTD PMID:18927307 NCBI chr10:70,516,462...70,621,973
Ensembl chr10:70,520,206...70,621,977
JBrowse link
G Ap2s1 adaptor related protein complex 2 subunit sigma 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of AP2S1 mRNA CTD PMID:16391804 NCBI chr 1:78,671,238...78,682,847
Ensembl chr 1:78,671,121...78,682,871
JBrowse link
G Apc APC regulator of WNT signaling pathway decreases expression ISO Irinotecan metabolite results in decreased expression of APC mRNA; Irinotecan results in decreased expression of APC mRNA CTD PMID:15956246 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase increases expression ISO Irinotecan metabolite results in increased expression of ARAF mRNA; Irinotecan results in increased expression of ARAF mRNA CTD PMID:15956246 NCBI chr  X:1,369,534...1,391,603
Ensembl chr  X:1,379,194...1,390,873
JBrowse link
G Areg amphiregulin multiple interactions
increases expression
ISO Gefitinib inhibits the reaction [Irinotecan metabolite results in increased expression of AREG mRNA]; Gefitinib inhibits the reaction [Irinotecan results in increased expression of AREG mRNA]
Irinotecan metabolite results in increased expression of AREG mRNA; Irinotecan results in increased expression of AREG mRNA
CTD PMID:15723263 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arf1 ADP-ribosylation factor 1 multiple interactions
decreases expression
ISO ARF1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
Irinotecan analog results in decreased expression of ARF1 mRNA
CTD PMID:18927307 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Arg2 arginase 2 affects expression EXP Irinotecan affects the expression of ARG2 mRNA CTD PMID:20097248 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Arhgap5 Rho GTPase activating protein 5 decreases expression
increases expression
ISO Irinotecan metabolite results in decreased expression of ARHGAP5 mRNA; Irinotecan results in decreased expression of ARHGAP5 mRNA
Irinotecan metabolite results in increased expression of ARHGAP5 mRNA; Irinotecan results in increased expression of ARHGAP5 mRNA
CTD PMID:15956246 NCBI chr 6:73,345,129...73,408,304
Ensembl chr 6:73,345,392...73,405,880
JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 decreases expression ISO Irinotecan analog results in decreased expression of ARHGEF12 mRNA CTD PMID:18927307 NCBI chr 8:47,259,377...47,393,042
Ensembl chr 8:47,259,404...47,393,503
JBrowse link
G Arhgef39 Rho guanine nucleotide exchange factor 39 decreases expression ISO Irinotecan analog results in decreased expression of ARHGEF39 mRNA CTD PMID:18927307 NCBI chr 5:58,998,209...59,001,779
Ensembl chr 5:58,995,249...59,001,800
JBrowse link
G Arid2 AT-rich interaction domain 2 decreases expression ISO Irinotecan analog results in decreased expression of ARID2 mRNA CTD PMID:18927307 NCBI chr 7:137,680,564...137,798,329
Ensembl chr 7:137,680,530...137,795,655
JBrowse link
G Arid4a AT-rich interaction domain 4A decreases expression ISO Irinotecan metabolite results in decreased expression of ARID4A mRNA; Irinotecan results in decreased expression of ARID4A mRNA CTD PMID:15956246 NCBI chr 6:93,461,713...93,532,901
Ensembl chr 6:93,461,713...93,532,901
JBrowse link
G Arl4c ADP ribosylation factor like GTPase 4C increases expression ISO Irinotecan analog results in increased expression of ARL4C mRNA CTD PMID:18927307 NCBI chr 9:95,783,651...95,787,092
Ensembl chr 9:95,786,508...95,787,094
JBrowse link
G Armc8 armadillo repeat containing 8 decreases expression ISO Irinotecan analog results in decreased expression of ARMC8 mRNA CTD PMID:18927307 NCBI chr 8:107,723,359...107,819,208
Ensembl chr 8:107,723,359...107,819,050
JBrowse link
G Arsb arylsulfatase B decreases expression ISO Irinotecan analog results in decreased expression of ARSB mRNA CTD PMID:18927307 NCBI chr 2:23,385,154...23,543,028
Ensembl chr 2:23,385,183...23,544,963
JBrowse link
G As3mt arsenite methyltransferase affects expression EXP Irinotecan affects the expression of AS3MT mRNA CTD PMID:20097248 NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569
JBrowse link
G Asb2 ankyrin repeat and SOCS box-containing 2 affects expression EXP Irinotecan affects the expression of ASB2 mRNA CTD PMID:20097248 NCBI chr 6:127,212,325...127,248,451
Ensembl chr 6:127,212,273...127,248,372
JBrowse link
G Ass1 argininosuccinate synthase 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of ASS1 mRNA CTD PMID:16391804 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Irinotecan metabolite results in increased expression of ATF3 mRNA; Irinotecan results in increased expression of ATF3 mRNA CTD PMID:15956246 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atg10 autophagy related 10 decreases expression ISO Irinotecan metabolite results in decreased expression of ATG10 mRNA; Irinotecan results in decreased expression of ATG10 mRNA CTD PMID:15956246 NCBI chr 2:19,853,546...20,152,918
Ensembl chr 2:19,853,546...20,152,884
JBrowse link
G Atl2 atlastin GTPase 2 increases expression ISO Irinotecan analog results in increased expression of ATL2 mRNA CTD PMID:18927307 NCBI chr 6:2,568,975...2,610,432
Ensembl chr 6:2,568,990...2,610,437
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO Irinotecan results in increased phosphorylation of ATM protein CTD PMID:22898888 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 affects expression EXP Irinotecan affects the expression of ATP2B1 mRNA CTD PMID:20097248 NCBI chr 7:41,114,606...41,223,138
Ensembl chr 7:41,114,697...41,220,579
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 decreases response to substance ISO ATP2B4 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP multiple interactions ISO ATP5PO mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr11:32,081,606...32,087,918
Ensembl chr11:32,081,574...32,088,002
JBrowse link
G Atp6v0b ATPase H+ transporting V0 subunit B increases response to substance ISO ATP6V0B protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 5:136,718,352...136,719,868
Ensembl chr 5:136,718,352...136,721,379
JBrowse link
G Atp7a ATPase copper transporting alpha decreases response to substance
increases export
ISO ATP7A protein results in decreased susceptibility to Irinotecan
ATP7A protein results in increased export of Irinotecan
CTD PMID:17510416 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 affects expression EXP Irinotecan affects the expression of ATP8B1 mRNA CTD PMID:20097248 NCBI chr18:60,013,388...60,152,920
Ensembl chr18:60,013,382...60,095,354
JBrowse link
G Atrx ATRX, chromatin remodeler decreases expression ISO Irinotecan analog results in decreased expression of ATRX mRNA CTD PMID:18927307 NCBI chr  X:76,820,110...76,979,155
Ensembl chr  X:76,692,970...76,708,878
Ensembl chr  X:76,692,970...76,708,878
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Irinotecan metabolite results in decreased expression of AURKB mRNA; Irinotecan results in decreased expression of AURKB mRNA CTD PMID:15956246 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G B2m beta-2 microglobulin increases expression EXP Irinotecan results in increased expression of B2M mRNA CTD PMID:20097248 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor increases expression ISO Irinotecan analog results in increased expression of BAMBI mRNA CTD PMID:18927307 NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased expression of BAX protein CTD PMID:15754201 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects response to substance
ISO [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in decreased expression of BCL2 protein; [Fluorouracil co-treated with Irinotecan] results in decreased expression of BCL2 mRNA; [Fluorouracil co-treated with Irinotecan] results in decreased expression of BCL2 protein
BCL2 protein affects the susceptibility to Irinotecan
CTD PMID:15754201, PMID:16391804, PMID:18949393 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO Irinotecan results in decreased expression of BCL2L1 mRNA
Irinotecan promotes the reaction [AS602868 results in decreased expression of BCL2L1 mRNA]
CTD PMID:16432164, PMID:18182997 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl7a BAF chromatin remodeling complex subunit BCL7A increases expression ISO Irinotecan metabolite results in increased expression of BCL7A mRNA; Irinotecan results in increased expression of BCL7A mRNA CTD PMID:15956246 NCBI chr12:38,659,294...38,691,191
Ensembl chr12:38,662,303...38,691,075
JBrowse link
G Bcl9 BCL9, transcription coactivator increases expression ISO Irinotecan metabolite results in increased expression of BCL9 mRNA; Irinotecan results in increased expression of BCL9 mRNA CTD PMID:15956246 NCBI chr 2:199,334,644...199,420,083
Ensembl chr 2:199,334,664...199,354,793
JBrowse link
G Bcr BCR activator of RhoGEF and GTPase decreases expression ISO Irinotecan analog results in decreased expression of BCR mRNA CTD PMID:18927307 NCBI chr20:14,421,250...14,546,406
Ensembl chr20:14,421,141...14,545,772
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression
ISO [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased cleavage of BID protein
Irinotecan results in decreased expression of BID protein
CTD PMID:15754201 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 affects expression EXP Irinotecan affects the expression of BIRC3 mRNA CTD PMID:20097248 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
ISO Irinotecan metabolite results in decreased expression of BIRC5 mRNA; Irinotecan results in decreased expression of BIRC5 mRNA
[Irinotecan co-treated with Bortezomib] results in decreased expression of BIRC5 protein; Irinotecan promotes the reaction [AS602868 results in decreased expression of BIRC5 mRNA]
CTD PMID:15956246, PMID:16373703, PMID:18182997 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bmp8a bone morphogenetic protein 8a increases expression ISO Irinotecan metabolite results in increased expression of BMP8A mRNA; Irinotecan results in increased expression of BMP8A mRNA CTD PMID:15956246 NCBI chr 5:141,007,462...141,033,511
Ensembl chr 5:141,007,462...141,033,511
JBrowse link
G Bod1l1 biorientation of chromosomes in cell division 1-like 1 decreases expression ISO Irinotecan analog results in decreased expression of BOD1L1 mRNA CTD PMID:18927307 NCBI chr14:73,738,137...73,792,935
Ensembl chr14:73,738,137...73,791,656
JBrowse link
G Boll boule homolog, RNA binding protein multiple interactions ISO BOLL mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 9:61,836,517...61,975,640
Ensembl chr 9:64,480,031...64,573,660
Ensembl chr 9:64,480,031...64,573,660
JBrowse link
G Btbd3 BTB domain containing 3 decreases expression ISO Irinotecan analog results in decreased expression of BTBD3 mRNA CTD PMID:18927307 NCBI chr 3:131,330,338...131,360,554
Ensembl chr 3:131,351,587...131,357,929
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression
affects expression
ISO
EXP
Irinotecan metabolite results in decreased expression of BUB1 mRNA; Irinotecan results in decreased expression of BUB1 mRNA
Irinotecan affects the expression of BUB1 mRNA
CTD PMID:15956246, PMID:20097248 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G C2 complement C2 affects expression EXP Irinotecan affects the expression of C2 mRNA CTD PMID:20097248 NCBI chr20:4,542,340...4,561,152
Ensembl chr20:4,542,340...4,561,152
JBrowse link
G C7 complement C7 increases expression EXP Irinotecan results in increased expression of C7 mRNA CTD PMID:20097248 NCBI chr 2:54,707,621...54,781,624
Ensembl chr 2:54,709,138...54,777,729
JBrowse link
G Cabin1 calcineurin binding protein 1 decreases expression ISO Irinotecan analog results in decreased expression of CABIN1 mRNA CTD PMID:18927307 NCBI chr20:13,836,032...13,963,003
Ensembl chr20:13,836,030...13,963,003
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I decreases expression ISO Irinotecan analog results in decreased expression of CACNA1I mRNA CTD PMID:18927307 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Casp1 caspase 1 increases cleavage
multiple interactions
affects expression
ISO
EXP
Irinotecan results in increased cleavage of CASP1 protein
[Irinotecan co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein; EVP 4593 inhibits the reaction [Irinotecan results in increased cleavage of CASP1 protein]; pyrazolanthrone inhibits the reaction [Irinotecan results in increased cleavage of CASP1 protein]
Irinotecan affects the expression of CASP1 mRNA
CTD PMID:20097248, PMID:26431797 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO [Irinotecan co-treated with alvocidib] results in increased activity of CASP3 protein; [Irinotecan co-treated with rucaparib] results in increased expression of CASP3 protein; Irinotecan promotes the reaction [AS602868 results in increased cleavage of and results in increased activity of CASP3 protein]; RNF34 protein inhibits the reaction [Irinotecan results in increased activity of CASP3 protein]; Ursodeoxycholic Acid promotes the reaction [Irinotecan results in increased activity of CASP3 protein]
Irinotecan results in increased expression of CASP3 protein
CTD PMID:11751522, PMID:16080519, PMID:16432164, PMID:18182997, PMID:22898888, PMID:30612311 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 decreases expression ISO Irinotecan metabolite results in decreased expression of CASP4 mRNA; Irinotecan results in decreased expression of CASP4 mRNA CTD PMID:15956246 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO Irinotecan promotes the reaction [AS602868 results in increased cleavage of and results in increased activity of CASP8 protein]; Irinotecan results in increased cleavage of and results in increased activity of CASP8 protein; Ursodeoxycholic Acid promotes the reaction [Irinotecan results in increased activity of CASP8 protein] CTD PMID:16432164, PMID:18182997 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Irinotecan results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Irinotecan results in increased activity of CASP9 protein]; Irinotecan promotes the reaction [AS602868 results in increased cleavage of and results in increased activity of CASP9 protein]; Irinotecan results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:18182997, PMID:22898888 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cblc Cbl proto-oncogene C affects expression EXP Irinotecan affects the expression of CBLC mRNA CTD PMID:20097248 NCBI chr 1:80,699,321...80,716,146
Ensembl chr 1:80,699,323...80,716,146
JBrowse link
G Cck cholecystokinin affects expression EXP Irinotecan affects the expression of CCK mRNA CTD PMID:20097248 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Ccn1 cellular communication network factor 1 decreases response to substance ISO CCN1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Irinotecan results in increased expression of CCN2 mRNA CTD PMID:20185912 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Irinotecan metabolite results in decreased expression of CCNA2 mRNA; Irinotecan results in decreased expression of CCNA2 mRNA CTD PMID:15956246 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression EXP Irinotecan results in decreased expression of CCNB1 mRNA CTD PMID:20097248 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb1ip1 cyclin B1 interacting protein 1 increases response to substance ISO CCNB1IP1 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr15:27,720,220...27,736,528
Ensembl chr15:27,720,223...27,733,785
JBrowse link
G Ccnb2 cyclin B2 increases response to substance
decreases expression
ISO
EXP
CCNB2 protein results in increased susceptibility to Irinotecan
Irinotecan results in decreased expression of CCNB2 mRNA
Irinotecan metabolite results in decreased expression of CCNB2 mRNA; Irinotecan results in decreased expression of CCNB2 mRNA
CTD PMID:15956246, PMID:16734730, PMID:20097248 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnf cyclin F decreases expression ISO Irinotecan metabolite results in decreased expression of CCNF mRNA; Irinotecan results in decreased expression of CCNF mRNA CTD PMID:15956246 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Irinotecan analog results in increased expression of CCNG2 mRNA CTD PMID:18927307 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 increases expression ISO Irinotecan metabolite results in increased expression of CCR1 mRNA; Irinotecan results in increased expression of CCR1 mRNA CTD PMID:15956246 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO Irinotecan metabolite results in decreased expression of CCR6 mRNA; Irinotecan results in decreased expression of CCR6 mRNA CTD PMID:15956246 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A decreases expression ISO Irinotecan analog results in decreased expression of CCT6A mRNA CTD PMID:18927307 NCBI chr12:30,491,584...30,501,813
Ensembl chr12:30,491,416...30,501,860
JBrowse link
G Cd163 CD163 molecule increases expression EXP Irinotecan results in increased expression of CD163 mRNA CTD PMID:20097248 NCBI chr 4:156,752,063...156,785,467
Ensembl chr 4:156,752,082...156,785,467
JBrowse link
G Cd36 CD36 molecule affects expression EXP Irinotecan affects the expression of CD36 mRNA CTD PMID:20097248 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd47 Cd47 molecule increases expression ISO Irinotecan analog results in increased expression of CD47 mRNA CTD PMID:18927307 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
JBrowse link
G Cd70 Cd70 molecule increases expression ISO Irinotecan metabolite results in increased expression of CD70 mRNA; Irinotecan results in increased expression of CD70 mRNA CTD PMID:15956246 NCBI chr 9:9,842,585...9,845,728
Ensembl chr 9:9,842,585...9,845,728
JBrowse link
G Cd80 Cd80 molecule increases expression ISO Irinotecan metabolite results in increased expression of CD80 mRNA; Irinotecan results in increased expression of CD80 mRNA CTD PMID:15956246 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cdc20 cell division cycle 20 affects expression
increases response to substance
EXP
ISO
Irinotecan affects the expression of CDC20 mRNA
CDC20 protein results in increased susceptibility to Irinotecan
CTD PMID:16734730, PMID:20097248 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc25b cell division cycle 25B decreases expression ISO Irinotecan metabolite results in decreased expression of CDC25B mRNA; Irinotecan results in decreased expression of CDC25B mRNA CTD PMID:15956246 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdc42bpa CDC42 binding protein kinase alpha decreases expression ISO Irinotecan analog results in decreased expression of CDC42BPA mRNA CTD PMID:18927307 NCBI chr13:98,231,326...98,447,762
Ensembl chr13:98,231,326...98,447,762
JBrowse link
G Cdca3 cell division cycle associated 3 decreases expression EXP Irinotecan results in decreased expression of CDCA3 mRNA CTD PMID:20097248 NCBI chr 4:157,347,876...157,351,889
Ensembl chr 4:157,348,020...157,351,604
JBrowse link
G Cdh4 cadherin 4 decreases expression ISO Irinotecan analog results in decreased expression of CDH4 mRNA CTD PMID:18927307 NCBI chr 3:175,220,520...175,283,144
Ensembl chr 3:175,144,495...175,279,761
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression EXP
ISO
Irinotecan results in decreased expression of CDK1 mRNA
Irinotecan metabolite results in decreased expression of CDK1 mRNA; Irinotecan results in decreased expression of CDK1 mRNA
CTD PMID:15956246, PMID:20097248 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk13 cyclin-dependent kinase 13 decreases expression ISO Irinotecan metabolite results in decreased expression of CDK13 mRNA; Irinotecan results in decreased expression of CDK13 mRNA CTD PMID:15956246 NCBI chr17:49,833,194...49,922,932
Ensembl chr17:49,833,400...49,921,550
JBrowse link
G Cdk5r2 cyclin-dependent kinase 5 regulatory subunit 2 increases expression ISO Irinotecan metabolite results in increased expression of CDK5R2 mRNA; Irinotecan results in increased expression of CDK5R2 mRNA CTD PMID:15956246 NCBI chr 9:82,120,059...82,121,527
Ensembl chr 9:82,120,059...82,121,527
JBrowse link
G Cdk6 cyclin-dependent kinase 6 affects expression ISO Irinotecan analog affects the expression of CDK6 mRNA CTD PMID:18927307 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
affects expression
ISO Irinotecan results in increased expression of CDKN1A mRNA; Irinotecan results in increased expression of CDKN1A protein
[Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased expression of CDKN1A protein
Irinotecan affects the expression of CDKN1A protein
CTD PMID:15132777, PMID:15754201, PMID:22510560, PMID:22898888 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects expression
increases response to substance
decreases expression
ISO Irinotecan affects the expression of CDKN2A protein
CDKN2A results in increased susceptibility to Irinotecan
Irinotecan results in decreased expression of CDKN2A mRNA
CTD PMID:16432164, PMID:22898888 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO
EXP
Irinotecan metabolite results in decreased expression of CDKN3 mRNA; Irinotecan results in decreased expression of CDKN3 mRNA CTD PMID:15956246, PMID:20097248 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
JBrowse link
G Cdon cell adhesion associated, oncogene regulated decreases expression ISO Irinotecan analog results in decreased expression of CDON mRNA CTD PMID:18927307 NCBI chr 8:36,625,757...36,712,091
Ensembl chr 8:36,625,733...36,710,949
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP Irinotecan results in increased expression of CEBPD mRNA CTD PMID:20097248 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Cel carboxyl ester lipase increases response to substance ISO CEL protein results in increased susceptibility to Irinotecan CTD PMID:9766666 NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522
JBrowse link
G Cela3b chymotrypsin like elastase 3B affects expression EXP Irinotecan affects the expression of CELA3B mRNA CTD PMID:20097248 NCBI chr 5:155,763,877...155,772,048
Ensembl chr 5:155,763,877...155,772,040
JBrowse link
G Cenpe centromere protein E decreases expression ISO Irinotecan analog results in decreased expression of CENPE mRNA; Irinotecan metabolite results in decreased expression of CENPE mRNA; Irinotecan results in decreased expression of CENPE mRNA CTD PMID:15956246, PMID:18927307 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747
JBrowse link
G Cenpf centromere protein F decreases expression ISO Irinotecan metabolite results in decreased expression of CENPF mRNA; Irinotecan results in decreased expression of CENPF mRNA CTD PMID:15956246 NCBI chr13:108,132,499...108,178,609
Ensembl chr13:108,132,499...108,178,609
JBrowse link
G Cep192 centrosomal protein 192 decreases expression ISO Irinotecan analog results in decreased expression of CEP192 mRNA CTD PMID:18927307 NCBI chr18:63,572,084...63,656,302
Ensembl chr18:63,524,452...63,656,286
JBrowse link
G Cep290 centrosomal protein 290 decreases expression ISO Irinotecan analog results in decreased expression of CEP290 mRNA CTD PMID:18927307 NCBI chr 7:40,217,269...40,306,327
Ensembl chr 7:40,217,269...40,306,327
JBrowse link
G Cep295 centrosomal protein 295 decreases expression ISO Irinotecan analog results in decreased expression of CEP295 mRNA CTD PMID:18927307 NCBI chr 8:13,871,065...13,909,249
Ensembl chr 8:13,871,213...13,909,188
JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis
increases response to substance
ISO CES1 protein results in increased hydrolysis of Irinotecan
CES1 mRNA results in increased susceptibility to Irinotecan
CTD PMID:15100172, PMID:15239142 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H increases expression
multiple interactions
increases response to substance
increases chemical synthesis
increases metabolic processing
affects response to substance
increases hydrolysis
ISO Irinotecan results in increased expression of CES2 mRNA
CES2 mRNA results in increased chemical synthesis of and results in increased abundance of Irinotecan; CES2 mRNA results in increased metabolism of and results in increased activity of Irinotecan; CES2 protein affects the metabolism of and results in increased activity of Irinotecan; CES2 protein results in increased hydrolysis of and results in increased activity of Irinotecan; CES2 protein results in increased metabolism of and results in increased activity of Irinotecan
CES2 protein results in increased susceptibility to Irinotecan
CES2 protein results in increased chemical synthesis of Irinotecan
CES2 protein results in increased metabolism of Irinotecan
CES2 protein affects the susceptibility to Irinotecan
CES2 protein results in increased hydrolysis of Irinotecan
CTD PMID:10728672, PMID:11716702, PMID:12171891, PMID:12171903, PMID:14581373, PMID:15100172, PMID:15475733, PMID:15592324, PMID:15655543, PMID:16203781, PMID:16963839 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Ces3a carboxylesterase 3a increases hydrolysis ISO CES3 protein results in increased hydrolysis of Irinotecan CTD PMID:15100172 NCBI chr19:37,070,705...37,079,411 JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression
affects response to substance
multiple interactions
ISO Irinotecan results in decreased expression of CFLAR protein
CFLAR protein affects the susceptibility to Irinotecan
CFLAR protein alternative form inhibits the reaction [Irinotecan results in increased activity of TNFSF10 protein]
CTD PMID:16373718 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cftr CF transmembrane conductance regulator affects expression EXP Irinotecan affects the expression of CFTR mRNA CTD PMID:20097248 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chd1 chromodomain helicase DNA binding protein 1 decreases expression ISO Irinotecan metabolite results in decreased expression of CHD1 mRNA; Irinotecan results in decreased expression of CHD1 mRNA CTD PMID:15956246 NCBI chr 1:57,692,828...57,756,762
Ensembl chr 1:57,692,836...57,755,485
JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation
multiple interactions
ISO Irinotecan results in increased phosphorylation of CHEK1 protein
Irinotecan results in increased phosphorylation of and results in increased activity of CHEK1 protein; SAR 020106 inhibits the reaction [Irinotecan results in increased phosphorylation of CHEK1 protein]
CTD PMID:22111927, PMID:22510560, PMID:22898888 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO Irinotecan results in increased phosphorylation of CHEK2 protein CTD PMID:22898888 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression EXP Irinotecan results in decreased expression of CKS2 mRNA CTD PMID:20097248 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
JBrowse link
G Cldn2 claudin 2 affects expression EXP Irinotecan affects the expression of CLDN2 mRNA CTD PMID:20097248 NCBI chr  X:111,122,552...111,133,188
Ensembl chr  X:111,122,552...111,137,769
JBrowse link
G Clec10a C-type lectin domain containing 10A increases expression EXP Irinotecan results in increased expression of CLEC10A mRNA CTD PMID:20097248 NCBI chr10:56,764,927...56,769,447
Ensembl chr10:56,764,927...56,769,457
JBrowse link
G Clgn calmegin increases expression ISO Irinotecan analog results in increased expression of CLGN mRNA CTD PMID:18927307 NCBI chr19:24,545,257...24,578,527
Ensembl chr19:24,545,318...24,576,798
JBrowse link
G Clps colipase affects expression EXP Irinotecan affects the expression of CLPS mRNA CTD PMID:20097248 NCBI chr20:5,803,447...5,806,107
Ensembl chr20:5,803,383...5,806,097
JBrowse link
G Cltc clathrin heavy chain decreases expression
multiple interactions
ISO Irinotecan analog results in decreased expression of CLTC mRNA
CLTC protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:18927307 NCBI chr10:74,014,560...74,070,578
Ensembl chr10:74,014,562...74,070,266
JBrowse link
G Cnnm2 cyclin and CBS domain divalent metal cation transport mediator 2 increases expression ISO Irinotecan analog results in increased expression of CNNM2 mRNA CTD PMID:18927307 NCBI chr 1:266,530,421...266,651,292
Ensembl chr 1:266,530,477...266,649,398
JBrowse link
G Col13a1 collagen type XIII alpha 1 chain increases expression ISO Irinotecan analog results in increased expression of COL13A1 mRNA CTD PMID:18927307 NCBI chr20:31,456,502...31,598,360
Ensembl chr20:31,456,852...31,598,118
JBrowse link
G Col4a4 collagen type IV alpha 4 chain decreases expression ISO Irinotecan analog results in decreased expression of COL4A4 mRNA CTD PMID:18927307 NCBI chr 9:88,314,763...88,357,183
Ensembl chr 9:88,232,455...88,357,182
JBrowse link
G Col6a1 collagen type VI alpha 1 chain increases expression ISO Irinotecan metabolite results in increased expression of COL6A1 mRNA; Irinotecan results in increased expression of COL6A1 mRNA CTD PMID:15956246 NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561
JBrowse link
G Col7a1 collagen type VII alpha 1 chain decreases response to substance ISO COL7A1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 8:117,694,441...117,726,844
Ensembl chr 8:117,694,605...117,726,844
JBrowse link
G Commd6 COMM domain containing 6 increases expression ISO Irinotecan metabolite results in increased expression of COMMD6 mRNA; Irinotecan results in increased expression of COMMD6 mRNA CTD PMID:15956246 NCBI chr15:86,136,096...86,142,672
Ensembl chr15:86,136,096...86,142,672
JBrowse link
G Copa COPI coat complex subunit alpha increases expression ISO Irinotecan analog results in increased expression of COPA mRNA CTD PMID:18927307 NCBI chr13:90,467,285...90,508,894
Ensembl chr13:90,467,265...90,508,932
JBrowse link
G Coq9 coenzyme Q9 decreases expression ISO Irinotecan results in decreased expression of COQ9 mRNA CTD PMID:20185912 NCBI chr19:10,583,855...10,596,848
Ensembl chr19:10,583,857...10,596,851
JBrowse link
G Cpe carboxypeptidase E increases expression ISO Irinotecan analog results in increased expression of CPE mRNA CTD PMID:18927307 NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
JBrowse link
G Crebbp CREB binding protein decreases expression ISO Irinotecan analog results in decreased expression of CREBBP mRNA; Irinotecan metabolite results in decreased expression of CREBBP mRNA; Irinotecan results in decreased expression of CREBBP mRNA CTD PMID:15956246, PMID:18927307 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 decreases expression ISO Irinotecan analog results in decreased expression of CRIM1 mRNA CTD PMID:18927307 NCBI chr 6:788,490...962,663
Ensembl chr 6:788,548...960,703
JBrowse link
G Ctbp2 C-terminal binding protein 2 decreases expression
multiple interactions
ISO Irinotecan analog results in decreased expression of CTBP2 mRNA
[Fluorouracil co-treated with Irinotecan] results in decreased expression of CTBP2 mRNA; CTBP2 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:16391804, PMID:18927307 NCBI chr 1:205,001,354...205,030,565
Ensembl chr 1:205,001,396...205,040,755
JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO Irinotecan analog results in increased expression of CTH mRNA CTD PMID:18927307 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Cul4a cullin 4A decreases expression ISO Irinotecan analog results in decreased expression of CUL4A mRNA CTD PMID:18927307 NCBI chr16:81,718,784...81,756,653
Ensembl chr16:81,719,028...81,756,654
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 affects expression EXP Irinotecan affects the expression of CXCL11 mRNA CTD PMID:20097248 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Irinotecan analog results in decreased expression of CXCL12 mRNA CTD PMID:18927307 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions
ISO Irinotecan results in increased expression of CXCL1 protein
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [Irinotecan results in increased expression of CXCL1 protein]]; carvacrol inhibits the reaction [Irinotecan results in increased expression of CXCL1 protein]
CTD PMID:27838229 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 affects expression EXP Irinotecan affects the expression of CYP27A1 mRNA CTD PMID:20097248 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO [selenomethylselenocysteine co-treated with Irinotecan] results in increased expression of CYP3A5 CTD PMID:15897249 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 affects expression EXP Irinotecan affects the expression of CYP4B1 mRNA CTD PMID:20097248 NCBI chr 5:134,508,728...134,526,103
Ensembl chr 5:134,508,730...134,526,089
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 affects expression EXP Irinotecan affects the expression of CYP4F1 mRNA CTD PMID:20097248 NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796
JBrowse link
G Daglb diacylglycerol lipase, beta decreases expression ISO Irinotecan analog results in decreased expression of DAGLB mRNA CTD PMID:18927307 NCBI chr12:13,113,073...13,157,748
Ensembl chr12:13,113,237...13,157,666
JBrowse link
G Dbf4 DBF4 zinc finger increases response to substance ISO DBF4 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 4:22,898,527...22,914,091
Ensembl chr 4:22,898,527...22,914,177
JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 decreases expression ISO Irinotecan analog results in decreased expression of DCAF8 mRNA CTD PMID:18927307 NCBI chr13:90,532,153...90,587,542
Ensembl chr13:90,532,326...90,591,796
JBrowse link
G Dclre1a DNA cross-link repair 1A decreases expression ISO Irinotecan metabolite results in decreased expression of DCLRE1A mRNA; Irinotecan results in decreased expression of DCLRE1A mRNA CTD PMID:15956246 NCBI chr 1:277,335,792...277,355,701
Ensembl chr 1:277,335,790...277,355,075
JBrowse link
G Dctn2 dynactin subunit 2 increases expression ISO Irinotecan analog results in increased expression of DCTN2 mRNA CTD PMID:18927307 NCBI chr 7:70,555,953...70,571,433
Ensembl chr 7:70,556,019...70,572,614
JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression ISO Irinotecan metabolite results in increased expression of DDB2 mRNA; Irinotecan results in increased expression of DDB2 mRNA CTD PMID:15956246 NCBI chr 3:80,030,437...80,052,984
Ensembl chr 3:80,030,437...80,052,953
JBrowse link
G Ddhd1 DDHD domain containing 1 decreases expression ISO Irinotecan analog results in decreased expression of DDHD1 mRNA CTD PMID:18927307 NCBI chr15:19,963,639...20,032,263
Ensembl chr15:19,965,187...20,032,191
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Irinotecan results in increased expression of DDIT3 mRNA CTD PMID:20097248 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression EXP Irinotecan results in increased expression of DDIT4 mRNA CTD PMID:20097248 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ddx17 DEAD-box helicase 17 decreases expression ISO Irinotecan results in decreased expression of DDX17 mRNA CTD PMID:20185912 NCBI chr 7:120,761,843...120,765,012
Ensembl chr 7:120,761,826...120,780,641
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked affects expression EXP Irinotecan affects the expression of DDX3X mRNA CTD PMID:20097248 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995
JBrowse link
G Dedd death effector domain-containing decreases expression ISO Irinotecan analog results in decreased expression of DEDD mRNA CTD PMID:18927307 NCBI chr13:89,706,932...89,721,825
Ensembl chr13:89,718,066...89,721,454
JBrowse link
G Dennd4a DENN domain containing 4A decreases expression ISO Irinotecan metabolite results in decreased expression of DENND4A mRNA; Irinotecan results in decreased expression of DENND4A mRNA CTD PMID:15956246 NCBI chr 8:70,293,355...70,406,675
Ensembl chr 8:70,317,586...70,406,751
JBrowse link
G Denr density regulated reinitiation and release factor decreases expression ISO Irinotecan analog results in decreased expression of DENR mRNA CTD PMID:18927307 NCBI chr12:38,095,717...38,117,758
Ensembl chr12:38,096,034...38,116,919
JBrowse link
G Depdc1b DEP domain containing 1B decreases expression ISO Irinotecan analog results in decreased expression of DEPDC1B mRNA CTD PMID:18927307 NCBI chr 2:39,980,796...40,069,982
Ensembl chr 2:40,000,313...40,069,975
JBrowse link
G Desi2 desumoylating isopeptidase 2 decreases expression ISO Irinotecan analog results in decreased expression of DESI2 mRNA CTD PMID:18927307 NCBI chr13:96,111,800...96,156,693
Ensembl chr13:96,111,800...96,154,685
JBrowse link
G Dffb DNA fragmentation factor subunit beta increases response to substance ISO DFFB protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 5:171,250,559...171,261,875
Ensembl chr 5:171,249,633...171,262,119
JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit decreases expression ISO Irinotecan analog results in decreased expression of DGCR8 mRNA CTD PMID:18927307 NCBI chr11:86,852,682...86,885,233
Ensembl chr11:86,852,711...86,885,224
JBrowse link
G Dip2a disco-interacting protein 2 homolog A decreases expression ISO Irinotecan analog results in decreased expression of DIP2A mRNA CTD PMID:18927307 NCBI chr20:13,044,056...13,127,971
Ensembl chr20:13,044,104...13,127,487
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein decreases expression ISO Irinotecan analog results in decreased expression of DLC1 mRNA CTD PMID:18927307 NCBI chr16:58,776,489...59,247,752
Ensembl chr16:59,077,574...59,247,754
JBrowse link
G Dld dihydrolipoamide dehydrogenase affects expression EXP Irinotecan affects the expression of DLD mRNA CTD PMID:20097248 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 decreases expression
multiple interactions
ISO Irinotecan analog results in decreased expression of DLG1 mRNA
DLG1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:18927307 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Dlx4 distal-less homeobox 4 increases expression ISO Irinotecan analog results in increased expression of DLX4 mRNA CTD PMID:18927307 NCBI chr10:82,958,525...82,963,919
Ensembl chr10:82,958,525...82,963,919
JBrowse link
G Dmac2l distal membrane arm assembly complex 2 like decreases expression ISO Irinotecan analog results in decreased expression of DMAC2L mRNA CTD PMID:18927307 NCBI chr 6:92,057,782...92,076,022
Ensembl chr 6:92,057,807...92,076,021
JBrowse link
G Dmwd DM1 locus, WD repeat containing increases expression ISO Irinotecan metabolite results in increased expression of DMWD mRNA; Irinotecan results in increased expression of DMWD mRNA CTD PMID:15956246 NCBI chr 1:79,981,270...79,987,997
Ensembl chr 1:79,981,355...79,987,562
JBrowse link
G Dok6 docking protein 6 decreases expression ISO Irinotecan results in decreased expression of DOK6 mRNA CTD PMID:20185912 NCBI chr18:86,420,361...86,878,142
Ensembl chr18:86,420,361...86,878,142
JBrowse link
G Dph2 diphthamide biosynthesis 2 decreases expression ISO Irinotecan analog results in decreased expression of DPH2 mRNA CTD PMID:18927307 NCBI chr 5:136,723,398...136,726,358
Ensembl chr 5:136,723,406...136,726,358
JBrowse link
G Dph6 diphthamine biosynthesis 6 decreases expression ISO Irinotecan analog results in decreased expression of DPH6 mRNA CTD PMID:18927307 NCBI chr 3:106,007,721...106,136,662
Ensembl chr 3:106,009,356...106,136,615
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases response to substance
decreases expression
ISO DPYD protein results in decreased susceptibility to Irinotecan
Irinotecan metabolite results in decreased expression of DPYD mRNA; Irinotecan results in decreased expression of DPYD mRNA
CTD PMID:15956246, PMID:16734730 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Drd5 dopamine receptor D5 multiple interactions ISO DRD5 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr14:77,220,579...77,222,006
Ensembl chr14:77,220,579...77,222,006
JBrowse link
G Drg1 developmentally regulated GTP binding protein 1 multiple interactions ISO [selenomethylselenocysteine co-treated with Irinotecan] results in decreased expression of DRG1 CTD PMID:15897249 NCBI chr14:83,460,540...83,476,568
Ensembl chr14:83,460,540...83,476,568
JBrowse link
G Dst dystonin decreases expression ISO Irinotecan analog results in decreased expression of DST mRNA CTD PMID:18927307 NCBI chr 9:37,902,336...38,296,961
Ensembl chr 9:37,902,303...38,196,273
JBrowse link
G Duox2 dual oxidase 2 affects expression EXP Irinotecan affects the expression of DUOX2 mRNA CTD PMID:20097248 NCBI chr 3:114,218,187...114,237,808
Ensembl chr 3:114,218,193...114,235,933
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression EXP Irinotecan results in increased expression of DUSP1 mRNA CTD PMID:20097248 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp2 dual specificity phosphatase 2 increases expression ISO Irinotecan metabolite results in increased expression of DUSP2 mRNA; Irinotecan results in increased expression of DUSP2 mRNA CTD PMID:15956246 NCBI chr 3:119,776,925...119,779,110
Ensembl chr 3:119,776,925...119,779,099
JBrowse link
G Dusp6 dual specificity phosphatase 6 affects expression EXP Irinotecan affects the expression of DUSP6 mRNA CTD PMID:20097248 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases expression ISO Irinotecan metabolite results in decreased expression of DYRK1A mRNA; Irinotecan results in decreased expression of DYRK1A mRNA CTD PMID:15956246 NCBI chr11:34,858,339...34,958,733
Ensembl chr11:34,865,532...34,956,536
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 decreases expression
affects expression
ISO
EXP
Irinotecan metabolite results in decreased expression of DYRK2 mRNA; Irinotecan results in decreased expression of DYRK2 mRNA
Irinotecan affects the expression of DYRK2 mRNA
CTD PMID:15956246, PMID:20097248 NCBI chr 7:61,785,423...61,816,775
Ensembl chr 7:61,786,309...61,798,729
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Irinotecan metabolite results in increased phosphorylation of EGFR protein]; bisindolylmaleimide I inhibits the reaction [Irinotecan results in increased phosphorylation of EGFR protein]; Gefitinib inhibits the reaction [Irinotecan metabolite results in increased phosphorylation of and results in increased activity of EGFR protein]; Gefitinib inhibits the reaction [Irinotecan results in increased phosphorylation of and results in increased activity of EGFR protein]; Go 6976 inhibits the reaction [Irinotecan metabolite results in increased phosphorylation of EGFR protein]; Go 6976 inhibits the reaction [Irinotecan results in increased phosphorylation of EGFR protein]; Irinotecan metabolite results in increased phosphorylation of and results in increased activity of EGFR protein; Irinotecan results in increased phosphorylation of and results in increased activity of EGFR protein; rottlerin inhibits the reaction [Irinotecan metabolite results in increased phosphorylation of EGFR protein]; rottlerin inhibits the reaction [Irinotecan results in increased phosphorylation of EGFR protein] CTD PMID:15723263 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 increases expression ISO
EXP
Irinotecan metabolite results in increased expression of EGR1 mRNA; Irinotecan results in increased expression of EGR1 mRNA CTD PMID:15956246, PMID:16280599, PMID:20097248 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 affects expression ISO Irinotecan analog affects the expression of EIF2AK4 mRNA CTD PMID:18927307 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
G Eml2 EMAP like 2 multiple interactions ISO EML2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 1:80,087,684...80,118,784
Ensembl chr 1:80,087,684...80,119,012
JBrowse link
G Eml4 EMAP like 4 affects expression EXP Irinotecan affects the expression of EML4 mRNA CTD PMID:20097248 NCBI chr 6:6,618,370...6,674,550
Ensembl chr 6:6,619,076...6,674,554
JBrowse link
G Eno1 enolase 1 decreases expression ISO Irinotecan analog results in decreased expression of ENO1 mRNA CTD PMID:18927307 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Ep300 E1A binding protein p300 decreases expression ISO Irinotecan metabolite results in decreased expression of EP300 mRNA; Irinotecan results in decreased expression of EP300 mRNA CTD PMID:15956246 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Eppk1 epiplakin 1 increases expression ISO Irinotecan analog results in increased expression of EPPK1 mRNA CTD PMID:18927307 NCBI chr 7:117,163,383...117,173,741 JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects expression EXP Irinotecan affects the expression of ERBB2 mRNA CTD PMID:20097248 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 increases expression ISO Irinotecan metabolite results in increased expression of ERBB4 mRNA; Irinotecan results in increased expression of ERBB4 mRNA CTD PMID:15956246 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 decreases expression ISO Irinotecan analog results in decreased expression of ERC1 mRNA CTD PMID:18927307 NCBI chr 4:152,087,393...152,380,023
Ensembl chr 4:152,087,379...152,380,184
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit decreases expression ISO Irinotecan results in decreased expression of ERCC1 protein CTD PMID:11593056 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Ereg epiregulin decreases expression ISO Irinotecan analog results in decreased expression of EREG mRNA CTD PMID:18927307 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor increases expression ISO Irinotecan metabolite results in increased expression of ETS2 mRNA; Irinotecan results in increased expression of ETS2 mRNA CTD PMID:15956246 NCBI chr11:36,075,709...36,092,495
Ensembl chr11:36,075,709...36,092,495
JBrowse link
G Etv6 ETS variant transcription factor 6 decreases expression ISO Irinotecan metabolite results in decreased expression of ETV6 mRNA; Irinotecan results in decreased expression of ETV6 mRNA CTD PMID:15956246 NCBI chr 4:167,754,684...167,992,370
Ensembl chr 4:167,754,525...167,992,168
JBrowse link
G Exoc4 exocyst complex component 4 decreases expression ISO Irinotecan analog results in decreased expression of EXOC4 mRNA CTD PMID:18927307 NCBI chr 4:60,549,128...61,358,305
Ensembl chr 4:60,549,197...61,355,994
JBrowse link
G F8 coagulation factor VIII multiple interactions ISO F8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr18:367,862...399,242
Ensembl chr18:367,862...399,242
JBrowse link
G Fabp1 fatty acid binding protein 1 affects expression EXP Irinotecan affects the expression of FABP1 mRNA CTD PMID:20097248 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fabp6 fatty acid binding protein 6 increases expression ISO Irinotecan analog results in increased expression of FABP6 mRNA CTD PMID:18927307 NCBI chr10:29,191,621...29,196,593
Ensembl chr10:29,191,623...29,196,563
JBrowse link
G Fam219a family with sequence similarity 219, member A decreases expression ISO Irinotecan analog results in decreased expression of FAM219A mRNA CTD PMID:18927307 NCBI chr 5:57,896,824...57,947,569
Ensembl chr 5:57,897,368...57,947,183
JBrowse link
G Fam3c FAM3 metabolism regulating signaling molecule C decreases expression ISO Irinotecan analog results in decreased expression of FAM3C mRNA CTD PMID:18927307 NCBI chr 4:49,388,962...49,439,892
Ensembl chr 4:49,387,989...49,439,867
JBrowse link
G Fancg FA complementation group G increases expression ISO Irinotecan metabolite results in increased expression of FANCG mRNA; Irinotecan results in increased expression of FANCG mRNA CTD PMID:15956246 NCBI chr 5:58,448,060...58,456,416
Ensembl chr 5:58,448,822...58,455,819
JBrowse link
G Farsb phenylalanyl-tRNA synthetase subunit beta decreases expression ISO Irinotecan analog results in decreased expression of FARSB mRNA CTD PMID:18927307 NCBI chr 9:84,324,456...84,383,674
Ensembl chr 9:84,324,442...84,383,687
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO Irinotecan results in increased expression of and results in increased localization of FAS protein; STAT1 protein promotes the reaction [Irinotecan results in increased localization of FAS protein]
Irinotecan results in increased expression of FAS mRNA
CTD PMID:16204068 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO [selenomethylselenocysteine co-treated with Irinotecan] results in increased expression of FASLG
Irinotecan results in increased expression of FASL protein
CTD PMID:15897249, PMID:21475811 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fbxw5 F-box and WD repeat domain containing 5 increases expression ISO Irinotecan results in increased expression of FBXW5 mRNA CTD PMID:20185912 NCBI chr 3:2,726,705...2,731,213
Ensembl chr 3:2,727,254...2,731,212
JBrowse link
G Fcf1 FCF1 rRNA-processing protein affects expression ISO Irinotecan analog affects the expression of FCF1 mRNA CTD PMID:18927307 NCBI chr 6:108,796,182...108,808,051
Ensembl chr 6:108,796,182...108,808,048
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb increases expression EXP Irinotecan results in increased expression of FCGR2B mRNA CTD PMID:20097248 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Irinotecan metabolite results in increased expression of FGF2 mRNA; Irinotecan results in increased expression of FGF2 mRNA CTD PMID:15956246 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf9 fibroblast growth factor 9 decreases expression ISO Irinotecan analog results in decreased expression of FGF9 mRNA CTD PMID:18927307 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316
JBrowse link
G Fgl2 fibrinogen-like 2 increases expression EXP Irinotecan results in increased expression of FGL2 mRNA CTD PMID:20097248 NCBI chr 4:10,323,598...10,329,241
Ensembl chr 4:10,323,607...10,329,241
JBrowse link
G Fh fumarate hydratase affects expression EXP Irinotecan affects the expression of FH mRNA CTD PMID:20097248 NCBI chr13:93,651,486...93,677,371
Ensembl chr13:93,651,484...93,677,377
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression EXP Irinotecan results in increased expression of FKBP5 mRNA CTD PMID:20097248 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 affects expression EXP Irinotecan affects the expression of FMO5 mRNA CTD PMID:20097248 NCBI chr 2:199,796,870...199,823,927
Ensembl chr 2:199,796,881...199,823,927
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Irinotecan analog results in increased expression of FN1 mRNA; Irinotecan metabolite results in increased expression of FN1 mRNA; Irinotecan results in increased expression of FN1 mRNA CTD PMID:15956246, PMID:18927307 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression
ISO Irinotecan metabolite results in increased expression of FOS mRNA; Irinotecan results in increased expression of FOS mRNA
Irinotecan results in decreased expression of FOS mRNA
CTD PMID:15956246, PMID:16432164 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Irinotecan metabolite results in increased expression of FOSB mRNA; Irinotecan results in increased expression of FOSB mRNA CTD PMID:15956246 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Foxa1 forkhead box A1 affects expression EXP Irinotecan affects the expression of FOXA1 mRNA CTD PMID:20097248 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G Frk fyn-related Src family tyrosine kinase affects expression EXP Irinotecan affects the expression of FRK mRNA CTD PMID:20097248 NCBI chr20:41,266,408...41,383,731
Ensembl chr20:41,266,566...41,383,424
JBrowse link
G Frmd5 FERM domain containing 5 decreases expression ISO Irinotecan analog results in decreased expression of FRMD5 mRNA CTD PMID:18927307 NCBI chr 3:113,480,780...113,755,286
Ensembl chr 3:113,483,269...113,525,864
JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase decreases expression ISO Irinotecan analog results in decreased expression of FTO mRNA CTD PMID:18927307 NCBI chr19:16,774,549...17,115,098
Ensembl chr19:16,772,744...17,115,113
JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 increases expression ISO Irinotecan results in increased expression of FXYD3 mRNA CTD PMID:15152939 NCBI chr 1:89,502,561...89,510,146
Ensembl chr 1:89,502,562...89,509,343
JBrowse link
G Fyb1 FYN binding protein 1 decreases expression ISO Irinotecan analog results in decreased expression of FYB1 mRNA CTD PMID:18927307 NCBI chr 2:55,834,904...55,983,805
Ensembl chr 2:55,835,151...55,983,804
JBrowse link
G G0s2 G0/G1switch 2 increases expression EXP Irinotecan results in increased expression of G0S2 mRNA CTD PMID:20097248 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G G2e3 G2/M-phase specific E3 ubiquitin protein ligase decreases expression ISO Irinotecan analog results in decreased expression of G2E3 mRNA CTD PMID:18927307 NCBI chr 6:72,092,148...72,123,878
Ensembl chr 6:72,092,194...72,122,497
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Irinotecan results in increased expression of GADD45A mRNA CTD PMID:20097248 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression EXP Irinotecan results in increased expression of GADD45G mRNA CTD PMID:20097248 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Gamt guanidinoacetate N-methyltransferase affects expression EXP Irinotecan affects the expression of GAMT mRNA CTD PMID:20097248 NCBI chr 7:12,314,848...12,317,998
Ensembl chr 7:12,314,848...12,317,998
JBrowse link
G Gata3 GATA binding protein 3 decreases expression ISO Irinotecan metabolite results in decreased expression of GATA3 mRNA; Irinotecan results in decreased expression of GATA3 mRNA CTD PMID:15956246 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Gata4 GATA binding protein 4 affects expression EXP Irinotecan affects the expression of GATA4 mRNA CTD PMID:20097248 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gcg glucagon affects expression EXP Irinotecan affects the expression of GCG mRNA CTD PMID:20097248 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Irinotecan metabolite results in increased expression of GDF15 mRNA; Irinotecan results in increased expression of GDF15 mRNA CTD PMID:15956246 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression EXP Irinotecan results in increased expression of GEM mRNA CTD PMID:20097248 NCBI chr 5:25,339,479...25,353,661
Ensembl chr 5:25,349,928...25,353,661
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 decreases expression ISO Irinotecan analog results in decreased expression of GGT1 mRNA CTD PMID:18927307 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Gja1 gap junction protein, alpha 1 affects expression
increases expression
ISO
EXP
Irinotecan analog affects the expression of GJA1 mRNA
Irinotecan results in increased expression of GJA1 mRNA
CTD PMID:18927307, PMID:20097248 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gk glycerol kinase decreases expression ISO Irinotecan analog results in decreased expression of GK mRNA CTD PMID:18927307 NCBI chr  X:54,227,291...54,303,897
Ensembl chr  X:54,227,397...54,303,864
JBrowse link
G Gkn1 gastrokine 1 affects expression EXP Irinotecan affects the expression of GKN1 mRNA CTD PMID:20097248 NCBI chr 4:119,143,070...119,148,358
Ensembl chr 4:119,143,070...119,148,358
JBrowse link
G Glrx3 glutaredoxin 3 affects expression ISO Irinotecan analog affects the expression of GLRX3 mRNA CTD PMID:18927307 NCBI chr 1:209,768,696...209,799,912
Ensembl chr 1:209,768,696...209,799,903
JBrowse link
G Gna13 G protein subunit alpha 13 increases expression ISO Irinotecan analog results in increased expression of GNA13 mRNA CTD PMID:18927307 NCBI chr10:97,647,196...97,680,030
Ensembl chr10:97,647,111...97,684,730
JBrowse link
G Gpatch2l G patch domain containing 2-like decreases expression ISO Irinotecan analog results in decreased expression of GPATCH2L mRNA CTD PMID:18927307 NCBI chr 6:110,093,767...110,228,943
Ensembl chr 6:110,093,819...110,227,475
JBrowse link
G Gpatch4 G patch domain containing 4 decreases expression ISO Irinotecan analog results in decreased expression of GPATCH4 mRNA CTD PMID:18927307 NCBI chr 2:187,404,731...187,424,047
Ensembl chr 2:187,415,262...187,424,045
JBrowse link
G Gphn gephyrin decreases expression EXP Irinotecan results in decreased expression of GPHN mRNA CTD PMID:20097248 NCBI chr 6:101,327,874...101,859,169
Ensembl chr 6:101,532,518...101,859,164
JBrowse link
G Gpr183 G protein-coupled receptor 183 increases expression ISO Irinotecan metabolite results in increased expression of GPR183 mRNA; Irinotecan results in increased expression of GPR183 mRNA CTD PMID:15956246 NCBI chr15:108,364,701...108,376,221
Ensembl chr15:108,364,701...108,376,221
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO Irinotecan metabolite results in increased expression of GPX3 mRNA; Irinotecan results in increased expression of GPX3 mRNA CTD PMID:15956246 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist increases expression EXP Irinotecan results in increased expression of GREM1 mRNA CTD PMID:20097248 NCBI chr 3:105,203,309...105,214,989
Ensembl chr 3:105,203,309...105,214,989
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 affects expression EXP Irinotecan affects the expression of GSTA3 mRNA CTD PMID:20097248 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta4 glutathione S-transferase alpha 4 affects expression EXP Irinotecan affects the expression of GSTA4 mRNA CTD PMID:20097248 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gzmb granzyme B affects expression EXP Irinotecan affects the expression of GZMB mRNA CTD PMID:20097248 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Irinotecan metabolite results in increased expression of H2AX mRNA; Irinotecan results in increased expression of H2AX mRNA CTD PMID:15956246 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression
multiple interactions
ISO Irinotecan metabolite results in increased expression of HBEGF mRNA; Irinotecan results in increased expression of HBEGF mRNA
Gefitinib inhibits the reaction [Irinotecan metabolite results in increased expression of HBEGF mRNA]; Gefitinib inhibits the reaction [Irinotecan results in increased expression of HBEGF mRNA]
CTD PMID:15723263 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hbg1 hemoglobin subunit gamma 1 decreases expression ISO Irinotecan analog results in decreased expression of HBG1 mRNA CTD PMID:18927307 NCBI chr 1:168,992,841...168,994,219
Ensembl chr 1:168,992,722...168,994,253
JBrowse link
G Hcfc1 host cell factor C1 decreases expression ISO Irinotecan analog results in decreased expression of HCFC1 mRNA CTD PMID:18927307 NCBI chr  X:156,812,012...156,837,227
Ensembl chr  X:156,812,064...156,837,227
JBrowse link
G Hectd2 HECT domain E3 ubiquitin protein ligase 2 decreases expression ISO Irinotecan analog results in decreased expression of HECTD2 mRNA CTD PMID:18927307 NCBI chr 1:255,186,729...255,254,307
Ensembl chr 1:255,185,629...255,254,307
JBrowse link
G Hells helicase, lymphoid specific decreases expression ISO Irinotecan analog results in decreased expression of HELLS mRNA CTD PMID:18927307 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183
JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases activity ISO Irinotecan results in increased activity of HES1 protein CTD PMID:19147571 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hgfac HGF activator affects expression EXP Irinotecan affects the expression of HGFAC mRNA CTD PMID:20097248 NCBI chr14:80,966,902...80,973,525
Ensembl chr14:80,966,903...80,973,456
JBrowse link
G Hk2 hexokinase 2 affects expression EXP Irinotecan affects the expression of HK2 mRNA CTD PMID:20097248 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO Irinotecan metabolite results in decreased expression of HMMR mRNA; Irinotecan results in decreased expression of HMMR mRNA CTD PMID:15956246 NCBI chr10:25,861,490...25,890,639
Ensembl chr10:25,861,490...25,890,639
JBrowse link
G Hmx1 H6 family homeobox 1 increases expression ISO Irinotecan results in increased expression of HMX1 mRNA CTD PMID:20185912 NCBI chr14:80,540,558...80,544,607
Ensembl chr14:80,541,075...80,544,342
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 decreases expression ISO Irinotecan analog results in decreased expression of HNRNPA1 mRNA CTD PMID:18927307 NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D decreases expression ISO Irinotecan analog results in decreased expression of HNRNPD mRNA CTD PMID:18927307 NCBI chr14:11,256,163...11,274,684
Ensembl chr14:11,256,268...11,274,578
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Irinotecan analog results in decreased expression of HNRNPDL mRNA CTD PMID:18927307 NCBI chr14:11,199,114...11,204,670
Ensembl chr14:11,198,896...11,202,669
JBrowse link
G Hrg histidine-rich glycoprotein increases expression ISO Irinotecan metabolite results in increased expression of HRG mRNA; Irinotecan results in increased expression of HRG mRNA CTD PMID:15956246 NCBI chr11:81,621,274...81,639,938
Ensembl chr11:81,621,283...81,639,952
JBrowse link
G Hs3st3b1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 increases expression ISO Irinotecan analog results in increased expression of HS3ST3B1 mRNA CTD PMID:18927307 NCBI chr10:50,369,097...50,402,584
Ensembl chr10:50,366,952...50,402,616
JBrowse link
G Hspa4l heat shock protein family A (Hsp70) member 4 like decreases expression ISO Irinotecan metabolite results in decreased expression of HSPA4L mRNA; Irinotecan results in decreased expression of HSPA4L mRNA CTD PMID:15956246 NCBI chr 2:127,625,737...127,682,864
Ensembl chr 2:127,625,683...127,677,503
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of HTATIP2 mRNA CTD PMID:16391804 NCBI chr 1:105,094,272...105,109,459
Ensembl chr 1:105,094,411...105,109,461
JBrowse link
G Hypk Huntingtin interacting protein K affects expression ISO Irinotecan analog affects the expression of HYPK mRNA CTD PMID:18927307 NCBI chr 3:113,423,684...113,425,064
Ensembl chr 3:113,423,693...113,424,846
JBrowse link
G Ibtk inhibitor of Bruton tyrosine kinase decreases expression ISO Irinotecan results in decreased expression of IBTK mRNA CTD PMID:20185912 NCBI chr 8:93,323,454...93,397,044
Ensembl chr 8:93,324,476...93,390,305
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Irinotecan metabolite results in decreased expression of ID2 mRNA; Irinotecan results in decreased expression of ID2 mRNA CTD PMID:15956246 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Ier3 immediate early response 3 increases expression ISO Irinotecan results in increased expression of IER3 mRNA CTD PMID:20185912 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Ifi27l2b interferon, alpha-inducible protein 27 like 2B multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of IFI27L2 mRNA CTD PMID:16391804 NCBI chr 6:127,336,305...127,337,791
Ensembl chr 6:127,336,305...127,337,791
JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 increases expression EXP Irinotecan results in increased expression of IFITM1 mRNA CTD PMID:20097248 NCBI chr 1:213,750,219...213,751,399
Ensembl chr 1:213,750,192...213,751,405
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 increases expression EXP Irinotecan results in increased expression of IFITM3 mRNA CTD PMID:20097248 NCBI chr 1:213,810,712...213,811,821
Ensembl chr 1:213,810,696...213,811,901
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
EXP Ciprofloxacin inhibits the reaction [Irinotecan promotes the reaction [Mitogens results in increased expression of IFNG protein]]; Irinotecan inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]; Irinotecan inhibits the reaction [Mitogens results in increased expression of IFNG protein]; Irinotecan promotes the reaction [Mitogens results in increased expression of IFNG protein]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of IFNG protein]; Thalidomide promotes the reaction [Irinotecan results in increased expression of IFNG protein] CTD PMID:16815871, PMID:19401694 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO Irinotecan metabolite results in increased expression of IGF1 mRNA; Irinotecan results in increased expression of IGF1 mRNA CTD PMID:15956246 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 increases expression EXP Irinotecan results in increased expression of IGFBP5 mRNA CTD PMID:20097248 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Ighg1 immunoglobulin heavy constant gamma 1 decreases expression ISO Irinotecan analog results in decreased expression of IGHG1 mRNA CTD PMID:18927307 NCBI chr 6:139,140,572...139,784,388
Ensembl chr 6:139,140,679...139,142,218
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases secretion
ISO
EXP
Deoxycholic Acid promotes the reaction [Irinotecan results in decreased secretion of IL10 protein]; Taurodeoxycholic Acid promotes the reaction [Irinotecan results in decreased secretion of IL10 protein]
Ciprofloxacin inhibits the reaction [Irinotecan inhibits the reaction [Mitogens results in increased expression of IL10 protein]]; Irinotecan inhibits the reaction [Mitogens results in increased expression of IL10 protein]
CTD PMID:19401694, PMID:26706406 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 affects expression EXP Irinotecan affects the expression of IL13RA1 mRNA CTD PMID:20097248 NCBI chr  X:122,724,081...122,783,801
Ensembl chr  X:122,724,129...122,781,479
JBrowse link
G Il15 interleukin 15 affects expression EXP Irinotecan affects the expression of IL15 mRNA CTD PMID:20097248 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il17a interleukin 17A increases expression ISO Irinotecan results in increased expression of IL17A mRNA; Irinotecan results in increased expression of IL17A protein CTD PMID:26431797 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18 interleukin 18 increases expression
multiple interactions
ISO Irinotecan results in increased expression of IL18 mRNA; Irinotecan results in increased expression of IL18 protein
[Fluorouracil co-treated with Irinotecan] results in decreased expression of IL18 mRNA; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL18 protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA; EVP 4593 inhibits the reaction [[Lipopolysaccharides co-treated with Irinotecan] results in increased expression of and results in increased secretion of IL18 protein]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with Irinotecan] results in increased expression of and results in increased secretion of IL18 protein]
[Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL18 protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA; EVP 4593 inhibits the reaction [Irinotecan results in increased expression of and results in increased secretion of IL18 protein]; pyrazolanthrone inhibits the reaction [Irinotecan results in increased expression of and results in increased secretion of IL18 protein]
CTD PMID:16391804, PMID:26431797 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects expression
increases expression
ISO
EXP
[Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL1B protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; EVP 4593 inhibits the reaction [[Lipopolysaccharides co-treated with Irinotecan] results in increased expression of and results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with Irinotecan] results in increased expression of and results in increased secretion of IL1B protein]
Irinotecan affects the expression of IL1B protein
Irinotecan metabolite results in increased expression of IL1B mRNA; Irinotecan results in increased expression of IL1B mRNA
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [Irinotecan results in increased expression of IL1B protein]]; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL1B protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; carvacrol inhibits the reaction [Irinotecan results in increased expression of IL1B protein]; Irinotecan results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein; Silymarin inhibits the reaction [Irinotecan results in increased expression of IL1B protein]
Irinotecan results in increased expression of IL1B mRNA; Irinotecan results in increased expression of IL1B protein
Ciprofloxacin inhibits the reaction [Irinotecan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Irinotecan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of IL1B protein]; Thalidomide promotes the reaction [Irinotecan results in increased expression of IL1B protein]
CTD PMID:15956246, PMID:16815871, PMID:18535404, PMID:19401694, PMID:26431797, PMID:27838229, PMID:28454924 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions
EXP Irinotecan results in decreased expression of IL2 protein
Ciprofloxacin inhibits the reaction [Irinotecan promotes the reaction [Mitogens results in increased expression of IL2 protein]]; Irinotecan inhibits the reaction [Mitogens results in increased expression of IL2 protein]; Irinotecan promotes the reaction [Mitogens results in increased expression of IL2 protein]; Thalidomide inhibits the reaction [Irinotecan results in decreased expression of IL2 protein]; Thalidomide promotes the reaction [Irinotecan results in decreased expression of IL2 protein]
CTD PMID:16815871, PMID:19401694 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
decreases response to substance
ISO
EXP
Irinotecan results in increased expression of IL6 mRNA; Irinotecan results in increased expression of IL6 protein
Silymarin inhibits the reaction [Irinotecan results in increased expression of IL6 protein]
IL6 protein results in decreased susceptibility to Irinotecan
Ciprofloxacin inhibits the reaction [Irinotecan inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Ciprofloxacin inhibits the reaction [Irinotecan promotes the reaction [Mitogens results in increased expression of IL6 protein]]; Irinotecan inhibits the reaction [Mitogens results in increased expression of IL6 protein]; Irinotecan promotes the reaction [Mitogens results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of IL6 protein]
CTD PMID:16815871, PMID:17537833, PMID:18535404, PMID:19401694, PMID:26431797, PMID:28454924 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Immp2l inner mitochondrial membrane peptidase subunit 2 decreases expression ISO Irinotecan analog results in decreased expression of IMMP2L mRNA CTD PMID:18927307 NCBI chr 6:60,958,351...61,859,457 JBrowse link
G Immt inner membrane mitochondrial protein affects expression ISO Irinotecan analog affects the expression of IMMT mRNA CTD PMID:18927307 NCBI chr 4:99,753,446...99,789,921
Ensembl chr 4:99,753,500...99,792,484
JBrowse link
G Ing3 inhibitor of growth family, member 3 decreases expression ISO Irinotecan analog results in decreased expression of ING3 mRNA CTD PMID:18927307 NCBI chr 4:49,017,235...49,044,450
Ensembl chr 4:49,017,311...49,042,990
JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO Irinotecan analog results in decreased expression of INSIG1 mRNA CTD PMID:18927307 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Itga2 integrin subunit alpha 2 increases expression ISO Irinotecan analog results in increased expression of ITGA2 mRNA CTD PMID:18927307 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itgae integrin subunit alpha E increases response to substance ISO ITGAE protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr10:59,652,324...59,711,885
Ensembl chr10:59,539,405...59,711,874
JBrowse link
G Itgav integrin subunit alpha V decreases expression ISO Irinotecan metabolite results in decreased expression of ITGAV mRNA; Irinotecan results in decreased expression of ITGAV mRNA CTD PMID:15956246 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgax integrin subunit alpha X increases expression ISO Irinotecan metabolite results in increased expression of ITGAX mRNA; Irinotecan results in increased expression of ITGAX mRNA CTD PMID:15956246 NCBI chr 1:199,555,560...199,576,948
Ensembl chr 1:199,555,722...199,576,932
JBrowse link
G Itgb3bp integrin subunit beta 3 binding protein decreases expression ISO Irinotecan metabolite results in decreased expression of ITGB3BP mRNA; Irinotecan results in decreased expression of ITGB3BP mRNA CTD PMID:15956246 NCBI chr 5:118,476,410...118,541,928
Ensembl chr 5:118,476,430...118,673,780
JBrowse link
G Jchain joining chain of multimeric IgA and IgM affects expression EXP Irinotecan affects the expression of JCHAIN mRNA CTD PMID:20097248 NCBI chr14:21,176,841...21,183,731
Ensembl chr14:21,177,237...21,183,542
JBrowse link
G Jpt1 Jupiter microtubule associated homolog 1 decreases expression ISO Irinotecan analog results in decreased expression of JPT1 mRNA CTD PMID:18927307 NCBI chr10:104,057,739...104,075,776
Ensembl chr10:104,057,697...104,075,777
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP
ISO
Irinotecan results in increased expression of JUN mRNA
Irinotecan metabolite results in increased expression of JUN mRNA; Irinotecan results in increased expression of JUN mRNA
CTD PMID:15956246, PMID:20097248 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kansl1 KAT8 regulatory NSL complex subunit 1 multiple interactions ISO KANSL1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog] CTD PMID:18927307 NCBI chr10:92,388,045...92,517,449
Ensembl chr10:92,389,530...92,476,109
JBrowse link
G Kat2b lysine acetyltransferase 2B increases expression ISO Irinotecan analog results in increased expression of KAT2B mRNA CTD PMID:18927307 NCBI chr 9:4,440,982...4,492,949 JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 increases expression EXP Irinotecan results in increased expression of KCNJ8 mRNA CTD PMID:20097248 NCBI chr 4:176,783,287...176,789,143
Ensembl chr 4:176,782,498...176,789,304
JBrowse link
G Khdrbs1 KH RNA binding domain containing, signal transduction associated 1 decreases expression ISO Irinotecan analog results in decreased expression of KHDRBS1 mRNA CTD PMID:18927307 NCBI chr 5:147,927,145...147,953,093
Ensembl chr 5:147,927,152...147,953,093
JBrowse link
G Kif14 kinesin family member 14 decreases expression ISO Irinotecan analog results in decreased expression of KIF14 mRNA CTD PMID:18927307 NCBI chr13:53,350,073...53,421,992
Ensembl chr13:53,351,717...53,420,111
JBrowse link
G Klf4 Kruppel like factor 4 increases expression ISO Irinotecan analog results in increased expression of KLF4 mRNA CTD PMID:18927307 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Klf9 Kruppel-like factor 9 increases expression ISO Irinotecan metabolite results in increased expression of KLF9 mRNA; Irinotecan results in increased expression of KLF9 mRNA CTD PMID:15956246 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO Irinotecan analog results in increased expression of KLHL24 mRNA CTD PMID:18927307 NCBI chr11:84,613,101...84,643,674
Ensembl chr11:84,615,760...84,633,504
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of KNG1 mRNA CTD PMID:16391804 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Knstrn kinetochore-localized astrin/SPAG5 binding protein decreases expression EXP Irinotecan results in decreased expression of KNSTRN mRNA CTD PMID:20097248 NCBI chr 3:110,618,256...110,638,024
Ensembl chr 3:110,618,298...110,638,046
JBrowse link
G Krit1 KRIT1, ankyrin repeat containing decreases expression ISO Irinotecan analog results in decreased expression of KRIT1 mRNA CTD PMID:18927307 NCBI chr 4:27,438,609...27,473,150
Ensembl chr 4:27,438,609...27,473,150
JBrowse link
G Krt18 keratin 18 multiple interactions ISO [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased cleavage of KRT18 protein CTD PMID:15754201 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt5 keratin 5 decreases expression ISO Irinotecan metabolite results in decreased expression of KRT5 mRNA; Irinotecan results in decreased expression of KRT5 mRNA CTD PMID:15956246 NCBI chr 7:143,320,142...143,324,536
Ensembl chr 7:143,316,920...143,453,546
JBrowse link
G Lbh LBH regulator of WNT signaling pathway decreases expression ISO Irinotecan analog results in decreased expression of LBH mRNA CTD PMID:18927307 NCBI chr 6:24,154,207...24,184,217
Ensembl chr 6:24,160,226...24,181,866
JBrowse link
G Lgals8 galectin 8 multiple interactions ISO LGALS8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr17:66,487,451...66,515,316
Ensembl chr17:66,487,457...66,511,870
JBrowse link
G Lmf1 lipase maturation factor 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of LMF1 mRNA CTD PMID:16391804 NCBI chr10:14,945,185...15,031,855
Ensembl chr10:14,945,265...15,031,942
JBrowse link
G Lmo7 LIM domain 7 affects expression EXP Irinotecan affects the expression of LMO7 mRNA CTD PMID:20097248 NCBI chr15:86,242,911...86,458,512
Ensembl chr15:86,243,148...86,457,739
JBrowse link
G LOC100302372 hypothetical protein LOC100302372 increases expression ISO Irinotecan analog results in increased expression of KIAA0040 mRNA CTD PMID:18927307 NCBI chr13:77,784,516...77,822,333
Ensembl chr13:77,784,808...77,822,333
JBrowse link
G LOC102548162 zinc finger protein 582-like multiple interactions ISO ZNF582 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 1:71,206,073...71,228,209 JBrowse link
G LOC103690190 histone H2A type 1-E decreases expression ISO Irinotecan metabolite results in decreased expression of H2AC6 mRNA; Irinotecan results in decreased expression of H2AC6 mRNA CTD PMID:15956246 NCBI chr17:44,747,686...44,748,229
Ensembl chr17:44,747,796...44,748,188
Ensembl chr17:44,747,796...44,748,188
JBrowse link
G LOC361985 similar to NICE-3 decreases expression ISO Irinotecan analog results in decreased expression of C1ORF43 mRNA CTD PMID:18927307 NCBI chr 2:189,400,696...189,413,614
Ensembl chr 2:189,400,696...189,413,608
JBrowse link
G Loxl3 lysyl oxidase-like 3 decreases expression ISO Irinotecan analog results in decreased expression of LOXL3 mRNA CTD PMID:18927307 NCBI chr 4:113,866,782...113,883,713
Ensembl chr 4:113,866,804...113,883,477
JBrowse link
G Lpcat1 lysophosphatidylcholine acyltransferase 1 decreases expression ISO Irinotecan analog results in decreased expression of LPCAT1 mRNA CTD PMID:18927307 NCBI chr 1:32,379,431...32,429,917
Ensembl chr 1:32,379,432...32,429,917
JBrowse link
G Lrch3 leucine rich repeats and calponin homology domain containing 3 decreases expression ISO Irinotecan analog results in decreased expression of LRCH3 mRNA CTD PMID:18927307 NCBI chr11:71,008,950...71,108,229
Ensembl chr11:71,012,061...71,108,184
JBrowse link
G Lsm7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated increases response to substance ISO LSM7 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 7:11,724,932...11,732,020
Ensembl chr 7:11,724,962...11,727,388
JBrowse link
G Ltf lactotransferrin decreases expression ISO Irinotecan metabolite results in decreased expression of LTF mRNA; Irinotecan results in decreased expression of LTF mRNA CTD PMID:15956246 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Ltv1 LTV1 ribosome biogenesis factor decreases expression ISO Irinotecan analog results in decreased expression of LTV1 mRNA CTD PMID:18927307 NCBI chr 1:7,323,043...7,335,766
Ensembl chr 1:7,323,040...7,335,936
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO Irinotecan metabolite results in decreased expression of MAD2L1 mRNA; Irinotecan results in decreased expression of MAD2L1 mRNA CTD PMID:15956246 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Maf MAF bZIP transcription factor affects expression EXP Irinotecan affects the expression of MAF mRNA CTD PMID:20097248 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 decreases expression EXP Irinotecan results in decreased expression of MAGI1 mRNA CTD PMID:20097248 NCBI chr 4:125,684,816...126,300,013
Ensembl chr 4:125,687,307...125,958,112
JBrowse link
G Mal mal, T-cell differentiation protein increases expression ISO Irinotecan metabolite results in increased expression of MAL mRNA; Irinotecan results in increased expression of MAL mRNA CTD PMID:15956246 NCBI chr 3:120,209,647...120,233,655
Ensembl chr 3:120,209,647...120,233,655
JBrowse link
G Mall mal, T-cell differentiation protein-like increases expression ISO Irinotecan metabolite results in increased expression of MALL mRNA; Irinotecan results in increased expression of MALL mRNA CTD PMID:15956246 NCBI chr 3:120,272,583...120,307,090
Ensembl chr 3:120,272,583...120,306,551
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Irinotecan metabolite results in decreased expression of MAP3K5 mRNA; Irinotecan results in decreased expression of MAP3K5 mRNA CTD PMID:15956246 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 increases expression EXP Irinotecan results in increased expression of MAP3K6 mRNA CTD PMID:20097248 NCBI chr 5:151,435,679...151,448,329
Ensembl chr 5:151,436,464...151,448,328
JBrowse link
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 decreases expression ISO Irinotecan analog results in decreased expression of MAP4K3 mRNA CTD PMID:18927307 NCBI chr 6:3,276,732...3,444,519
Ensembl chr 6:3,276,738...3,444,519
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression
ISO
EXP
Irinotecan results in increased phosphorylation of and results in increased activity of MAPK1 protein
Irinotecan results in increased expression of MAPK1 mRNA
CTD PMID:16432164, PMID:20097248 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk13 mitogen activated protein kinase 13 affects expression EXP Irinotecan affects the expression of MAPK13 mRNA CTD PMID:20097248 NCBI chr20:6,018,374...6,027,467
Ensembl chr20:6,018,374...6,027,473
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Irinotecan results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:16432164 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 increases expression ISO Irinotecan analog results in increased expression of MARCHF6 mRNA CTD PMID:18927307 NCBI chr 2:84,533,546...84,608,743
Ensembl chr 2:84,536,669...84,608,712
JBrowse link
G Matn2 matrilin 2 increases expression ISO Irinotecan analog results in increased expression of MATN2 mRNA CTD PMID:18927307 NCBI chr 7:72,985,832...73,210,093
Ensembl chr 7:72,985,495...73,207,695
JBrowse link
G Matr3 matrin 3 decreases expression ISO Irinotecan analog results in decreased expression of MATR3 mRNA CTD PMID:18927307 NCBI chr18:28,351,691...28,390,764
Ensembl chr18:28,361,283...28,390,717
JBrowse link
G Mbnl1 muscleblind-like splicing regulator 1 decreases expression ISO Irinotecan analog results in decreased expression of MBNL1 mRNA CTD PMID:18927307 NCBI chr 2:150,698,248...150,867,791
Ensembl chr 2:150,756,185...150,869,690
JBrowse link
G Mbp myelin basic protein decreases expression ISO Irinotecan analog results in decreased expression of MBP mRNA CTD PMID:18927307 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mccc2 methylcrotonoyl-CoA carboxylase 2 decreases expression
multiple interactions
ISO Irinotecan analog results in decreased expression of MCCC2 mRNA
MCCC2 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:18927307 NCBI chr 2:30,175,017...30,246,028
Ensembl chr 2:30,175,018...30,246,010
JBrowse link
G Mcf2l MCF.2 cell line derived transforming sequence-like decreases expression ISO Irinotecan metabolite results in decreased expression of MCF2L mRNA; Irinotecan results in decreased expression of MCF2L mRNA CTD PMID:15956246 NCBI chr16:81,839,686...81,986,007
Ensembl chr16:81,839,653...81,980,027
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases response to substance ISO MCL1 protein results in decreased susceptibility to Irinotecan CTD PMID:21507240 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO Irinotecan metabolite results in decreased expression of MCM4 mRNA; Irinotecan results in decreased expression of MCM4 mRNA CTD PMID:15956246 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Irinotecan metabolite results in increased expression of MDM2 mRNA; Irinotecan results in increased expression of MDM2 mRNA CTD PMID:15956246 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mdn1 midasin AAA ATPase 1 affects expression ISO Irinotecan analog affects the expression of MDN1 mRNA CTD PMID:18927307 NCBI chr 5:47,894,526...48,036,071
Ensembl chr 5:47,894,530...48,036,287
JBrowse link
G Med13 mediator complex subunit 13 decreases expression ISO Irinotecan analog results in decreased expression of MED13 mRNA CTD PMID:18927307 NCBI chr10:73,702,327...73,787,084
Ensembl chr10:73,702,327...73,787,083
JBrowse link
G Mef2b myocyte enhancer factor 2B increases expression ISO Irinotecan metabolite results in increased expression of MEF2B mRNA; Irinotecan results in increased expression of MEF2B mRNA CTD PMID:15956246 NCBI chr16:21,001,204...21,017,651
Ensembl chr16:21,001,206...21,017,163
JBrowse link
G Mettl7b methyltransferase like 7B affects expression EXP Irinotecan affects the expression of METTL7B mRNA CTD PMID:20097248 NCBI chr 7:3,383,876...3,386,522
Ensembl chr 7:3,383,879...3,386,522
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression
increases response to substance
ISO Irinotecan metabolite results in decreased expression of MGMT mRNA
MGMT mRNA results in increased susceptibility to Irinotecan
CTD PMID:15239142, PMID:18492797 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Minpp1 multiple inositol-polyphosphate phosphatase 1 affects expression EXP Irinotecan affects the expression of MINPP1 mRNA CTD PMID:20097248 NCBI chr 1:251,045,352...251,071,045
Ensembl chr 1:251,045,440...251,071,040
JBrowse link
G Mip major intrinsic protein of lens fiber decreases expression ISO Irinotecan analog results in decreased expression of MIP mRNA CTD PMID:18927307 NCBI chr 7:2,635,743...2,642,995
Ensembl chr 7:2,635,743...2,642,848
JBrowse link
G Mir128-1 microRNA 128-1 increases expression ISO Irinotecan results in increased expression of MIR128-1 mRNA CTD PMID:22898888 NCBI chr13:44,916,534...44,916,615
Ensembl chr13:44,916,534...44,916,615
JBrowse link
G Mir34a microRNA 34a increases expression ISO Irinotecan results in increased expression of MIR34A mRNA CTD PMID:22898888 NCBI chr 5:167,092,491...167,092,592
Ensembl chr 5:167,092,491...167,092,592
JBrowse link
G Mir449a microRNA 449a increases expression ISO Irinotecan results in increased expression of MIR449A mRNA CTD PMID:22898888 NCBI chr 2:44,897,601...44,897,691
Ensembl chr 2:44,897,601...44,897,691
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Irinotecan co-treated with rucaparib] results in decreased expression of MKI67 protein CTD PMID:30612311 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mkx mohawk homeobox decreases expression ISO Irinotecan analog results in decreased expression of MKX mRNA CTD PMID:18927307 NCBI chr17:60,537,615...60,553,284
Ensembl chr17:60,537,935...60,549,750
JBrowse link
G Mlh1 mutL homolog 1 affects response to substance ISO MLH1 protein affects the susceptibility to Irinotecan CTD PMID:18949393 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Mlxipl MLX interacting protein-like affects expression EXP Irinotecan affects the expression of MLXIPL mRNA CTD PMID:20097248 NCBI chr12:24,590,645...24,619,639 JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Irinotecan metabolite results in increased expression of MMP9 mRNA; Irinotecan results in increased expression of MMP9 mRNA CTD PMID:15956246 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
decreases expression
ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [Irinotecan results in increased activity of MPO protein]]; carvacrol inhibits the reaction [Irinotecan results in increased activity of MPO protein]
Irinotecan metabolite results in decreased expression of MPO mRNA; Irinotecan results in decreased expression of MPO mRNA
CTD PMID:15956246, PMID:27838229 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mpp7 membrane palmitoylated protein 7 increases expression ISO Irinotecan analog results in increased expression of MPP7 mRNA CTD PMID:18927307 NCBI chr17:60,057,077...60,250,303
Ensembl chr17:60,059,949...60,250,352
JBrowse link
G Mpst mercaptopyruvate sulfurtransferase decreases expression ISO Irinotecan results in decreased expression of MPST mRNA CTD PMID:20185912 NCBI chr 7:119,626,636...119,631,317
Ensembl chr 7:119,626,637...119,631,425
JBrowse link
G Mrps30 mitochondrial ribosomal protein S30 decreases expression ISO Irinotecan analog results in decreased expression of MRPS30 mRNA CTD PMID:18927307 NCBI chr 2:51,042,548...51,049,423
Ensembl chr 2:51,042,546...51,049,449
JBrowse link
G Msh2 mutS homolog 2 decreases expression
affects response to substance
ISO Irinotecan metabolite results in decreased expression of MSH2 mRNA; Irinotecan results in decreased expression of MSH2 mRNA
MSH2 protein affects the susceptibility to Irinotecan
CTD PMID:15956246, PMID:18949393 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Msr1 macrophage scavenger receptor 1 increases expression EXP Irinotecan results in increased expression of MSR1 mRNA CTD PMID:20097248 NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of ATP6 mRNA CTD PMID:16391804 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
JBrowse link
G Mt1 metallothionein 1 increases expression EXP Irinotecan results in increased expression of MT1A mRNA CTD PMID:20097248 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like decreases expression ISO Irinotecan analog results in decreased expression of MTHFD1L mRNA CTD PMID:18927307 NCBI chr 1:40,529,092...40,719,232
Ensembl chr 1:40,529,045...40,719,391
JBrowse link
G Mthfs methenyltetrahydrofolate synthetase decreases expression ISO Irinotecan metabolite results in decreased expression of MTHFS mRNA; Irinotecan results in decreased expression of MTHFS mRNA CTD PMID:15956246 NCBI chr 8:96,564,877...96,614,386
Ensembl chr 8:96,564,877...96,614,348
JBrowse link
G Mtmr4 myotubularin related protein 4 affects expression EXP Irinotecan affects the expression of MTMR4 mRNA CTD PMID:20097248 NCBI chr10:74,886,600...74,909,532
Ensembl chr10:74,886,985...74,909,533
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases response to substance ISO MYB protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Myh10 myosin heavy chain 10 decreases expression ISO Irinotecan analog results in decreased expression of MYH10 mRNA CTD PMID:18927307 NCBI chr10:55,274,910...55,406,738
Ensembl chr10:55,275,411...55,406,732
JBrowse link
G Mysm1 myb-like, SWIRM and MPN domains 1 decreases expression ISO Irinotecan analog results in decreased expression of MYSM1 mRNA CTD PMID:18927307 NCBI chr 5:113,902,115...113,939,083
Ensembl chr 5:113,906,803...113,939,127
JBrowse link
G N4bp1 Nedd4 binding protein 1 decreases expression ISO Irinotecan analog results in decreased expression of N4BP1 mRNA CTD PMID:18927307 NCBI chr19:21,218,123...21,268,539
Ensembl chr19:21,218,465...21,266,964
JBrowse link
G Nck1 NCK adaptor protein 1 decreases expression ISO Irinotecan metabolite results in decreased expression of NCK1 mRNA; Irinotecan results in decreased expression of NCK1 mRNA CTD PMID:15956246 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 increases expression ISO Irinotecan metabolite results in increased expression of NCOA1 mRNA; Irinotecan results in increased expression of NCOA1 mRNA CTD PMID:15956246 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions
decreases expression
ISO NCOR1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
Irinotecan analog results in decreased expression of NCOR1 mRNA
CTD PMID:18927307 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Ncstn nicastrin affects response to substance ISO NCSTN protein affects the susceptibility to Irinotecan CTD PMID:19147571 NCBI chr13:90,451,046...90,467,256
Ensembl chr13:90,451,044...90,467,256
JBrowse link
G Ndrg1 N-myc downstream regulated 1 decreases response to substance ISO NDRG1 protein results in decreased susceptibility to Irinotecan CTD PMID:15867226 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression ISO Irinotecan metabolite results in decreased expression of NEK2 mRNA; Irinotecan results in decreased expression of NEK2 mRNA CTD PMID:15956246 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
increases activity
EXP
ISO
Irinotecan results in increased expression of NFKB1 mRNA
carvacrol inhibits the reaction [Irinotecan results in increased expression of NFKB1 protein]; Silymarin inhibits the reaction [Irinotecan results in increased expression of NFKB1 protein]
Irinotecan results in increased activity of NFKB1 protein
CTD PMID:18182997, PMID:20097248, PMID:27838229, PMID:28454924 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
increases response to substance
multiple interactions
EXP
ISO
Irinotecan results in increased expression of NFKBIA mRNA
NFKBIA gene mutant form results in increased susceptibility to Irinotecan
AS602868 inhibits the reaction [Irinotecan results in increased phosphorylation of and results in decreased expression of NFKBIA protein]; Irinotecan results in increased phosphorylation of and results in decreased expression of NFKBIA protein
CTD PMID:12675310, PMID:18182997, PMID:20097248 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nid1 nidogen 1 increases expression ISO Irinotecan metabolite results in increased expression of NID1 mRNA; Irinotecan results in increased expression of NID1 mRNA CTD PMID:15956246 NCBI chr17:90,553,161...90,627,133
Ensembl chr17:90,553,394...90,627,101
JBrowse link
G Nmu neuromedin U affects expression EXP Irinotecan affects the expression of NMU mRNA CTD PMID:20097248 NCBI chr14:34,353,683...34,381,968
Ensembl chr14:34,354,503...34,381,828
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression ISO Irinotecan analog results in decreased expression of NQO1 mRNA CTD PMID:18927307 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases response to substance ISO NR3C1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects expression EXP Irinotecan affects the expression of NR3C2 mRNA CTD PMID:20097248 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of NRIP1 mRNA CTD PMID:16391804 NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase decreases expression ISO Irinotecan analog results in decreased expression of NSF mRNA CTD PMID:18927307 NCBI chr10:91,879,608...91,986,242
Ensembl chr10:91,878,633...92,008,082
JBrowse link
G Nsmaf neutral sphingomyelinase activation associated factor decreases expression ISO Irinotecan results in decreased expression of NSMAF mRNA CTD PMID:20185912 NCBI chr 5:19,499,111...19,560,308
Ensembl chr 5:19,499,480...19,559,393
JBrowse link
G Nup153 nucleoporin 153 decreases expression ISO Irinotecan analog results in decreased expression of NUP153 mRNA CTD PMID:18927307 NCBI chr17:18,358,712...18,411,368
Ensembl chr17:18,358,712...18,411,368
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 decreases expression ISO
EXP
Irinotecan analog results in decreased expression of NUSAP1 mRNA
Irinotecan results in decreased expression of NUSAP1 mRNA
CTD PMID:18927307, PMID:20097248 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971
JBrowse link
G Oat ornithine aminotransferase decreases expression EXP Irinotecan results in decreased expression of OAT mRNA CTD PMID:30012503 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Ophn1 oligophrenin 1 increases expression ISO Irinotecan analog results in increased expression of OPHN1 mRNA CTD PMID:18927307 NCBI chr  X:68,185,865...68,579,518
Ensembl chr  X:68,189,161...68,563,137
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases response to substance ISO ORC1 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 5:128,186,651...128,212,901
Ensembl chr 5:128,190,708...128,210,445
JBrowse link
G Osmr oncostatin M receptor decreases response to substance
increases expression
ISO OSMR protein results in decreased susceptibility to Irinotecan
Irinotecan metabolite results in increased expression of OSMR mRNA; Irinotecan results in increased expression of OSMR mRNA
CTD PMID:15956246, PMID:16734730 NCBI chr 2:56,107,491...56,163,522
Ensembl chr 2:56,110,777...56,151,531
JBrowse link
G Pag1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 increases expression ISO Irinotecan analog results in increased expression of PAG1 mRNA CTD PMID:18927307 NCBI chr 2:94,266,104...94,277,680
Ensembl chr 2:94,266,213...94,277,676
JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase decreases expression ISO Irinotecan analog results in decreased expression of PAM mRNA CTD PMID:18927307 NCBI chr 9:111,028,543...111,177,588
Ensembl chr 9:111,028,575...111,177,602
JBrowse link
G Pan3 poly(A) specific ribonuclease subunit PAN3 decreases expression ISO Irinotecan analog results in decreased expression of PAN3 mRNA CTD PMID:18927307 NCBI chr12:9,214,116...9,331,901
Ensembl chr12:9,216,536...9,331,195
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
ISO Irinotecan results in increased expression of PARP1 protein
rucaparib inhibits the reaction [Irinotecan results in increased expression of PARP1 protein]
CTD PMID:30612311 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression ISO Irinotecan results in decreased expression of PAWR mRNA CTD PMID:20185912 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Pax5 paired box 5 decreases expression ISO Irinotecan analog results in decreased expression of PAX5 mRNA CTD PMID:18927307 NCBI chr 5:60,007,587...60,191,973
Ensembl chr 5:60,007,587...60,191,941
JBrowse link
G Pax7 paired box 7 decreases expression ISO Irinotecan analog results in decreased expression of PAX7 mRNA CTD PMID:18927307 NCBI chr 5:158,211,001...158,313,510
Ensembl chr 5:158,214,616...158,313,426
JBrowse link
G Pbxip1 PBX homeobox interacting protein 1 decreases response to substance ISO PBXIP1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:188,763,887...188,776,445
Ensembl chr 2:188,766,535...188,776,439
JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 decreases expression ISO Irinotecan analog results in decreased expression of PCBD2 mRNA CTD PMID:18927307 NCBI chr17:8,929,675...8,980,712
Ensembl chr17:8,929,810...8,980,571
JBrowse link
G Pcdhgc3 protocadherin gamma subfamily C, 3 increases expression ISO Irinotecan metabolite results in increased expression of PCDHGC3 mRNA; Irinotecan results in increased expression of PCDHGC3 mRNA CTD PMID:15956246 NCBI chr18:30,954,552...30,971,113
Ensembl chr18:30,913,842...30,969,361
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 affects expression EXP Irinotecan affects the expression of PCK1 mRNA CTD PMID:20097248 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pclaf PCNA clamp associated factor multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of PCLAF mRNA CTD PMID:16391804 NCBI chr 8:71,514,281...71,526,182
Ensembl chr 8:71,514,281...71,526,182
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Irinotecan inhibits the reaction [nitrosobenzylmethylamine results in increased expression of PCNA protein] CTD PMID:15547733 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression
affects expression
ISO
EXP
Irinotecan metabolite results in decreased expression of PDE4B mRNA; Irinotecan results in decreased expression of PDE4B mRNA
Irinotecan affects the expression of PDE4B mRNA
CTD PMID:15956246, PMID:20097248 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pdlim5 PDZ and LIM domain 5 decreases expression ISO Irinotecan analog results in decreased expression of PDLIM5 mRNA CTD PMID:18927307 NCBI chr 2:247,815,214...247,989,198
Ensembl chr 2:247,818,243...247,988,462
JBrowse link
G Pgm2l1 phosphoglucomutase 2-like 1 increases expression ISO Irinotecan analog results in increased expression of PGM2L1 mRNA CTD PMID:18927307 NCBI chr 1:165,237,847...165,286,980
Ensembl chr 1:165,237,847...165,286,980
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO Irinotecan analog results in decreased expression of PHLDA1 mRNA CTD PMID:18927307 NCBI chr 7:54,247,460...54,249,664
Ensembl chr 7:54,247,460...54,249,664
JBrowse link
G Phlda2 pleckstrin homology-like domain, family A, member 2 increases expression ISO Irinotecan results in increased expression of PHLDA2 mRNA CTD PMID:20185912 NCBI chr 1:216,701,345...216,704,479
Ensembl chr 1:216,702,319...216,703,534
JBrowse link
G Pigw phosphatidylinositol glycan anchor biosynthesis, class W decreases expression ISO Irinotecan analog results in decreased expression of PIGW mRNA CTD PMID:18927307 NCBI chr10:72,194,774...72,198,415
Ensembl chr10:72,194,929...72,196,437
JBrowse link
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta affects expression EXP Irinotecan affects the expression of PIP5K1B mRNA CTD PMID:20097248 NCBI chr 1:242,168,462...242,441,247
Ensembl chr 1:242,168,462...242,441,247
JBrowse link
G Pkdcc protein kinase domain containing, cytoplasmic decreases expression ISO Irinotecan results in decreased expression of PKDCC mRNA CTD PMID:20185912 NCBI chr 6:6,427,657...6,436,974
Ensembl chr 6:6,427,657...6,436,974
JBrowse link
G Pla2g1b phospholipase A2 group IB affects expression EXP Irinotecan affects the expression of PLA2G1B mRNA CTD PMID:20097248 NCBI chr12:46,879,346...46,890,234
Ensembl chr12:46,879,343...46,889,082
JBrowse link
G Pla2g2d phospholipase A2, group IID affects expression EXP Irinotecan affects the expression of PLA2G2D mRNA CTD PMID:20097248 NCBI chr 5:157,222,636...157,228,795
Ensembl chr 5:157,222,636...157,228,791
JBrowse link
G Plat plasminogen activator, tissue type increases expression
decreases expression
EXP
ISO
Irinotecan results in increased expression of PLAT mRNA
Irinotecan analog results in decreased expression of PLAT mRNA
CTD PMID:18927307, PMID:20097248 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plcb1 phospholipase C beta 1 decreases expression EXP Irinotecan results in decreased expression of PLCB1 mRNA CTD PMID:20097248 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plcxd2 phosphatidylinositol-specific phospholipase C, X domain containing 2 increases expression ISO Irinotecan analog results in increased expression of PLCXD2 mRNA CTD PMID:18927307 NCBI chr11:57,207,656...57,260,001
Ensembl chr11:57,207,656...57,260,568
JBrowse link
G Pld1 phospholipase D1 affects expression EXP Irinotecan affects the expression of PLD1 mRNA CTD PMID:20097248 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Plekha5 pleckstrin homology domain containing A5 decreases expression ISO Irinotecan analog results in decreased expression of PLEKHA5 mRNA CTD PMID:18927307 NCBI chr 4:174,605,462...174,774,692
Ensembl chr 4:174,605,476...174,774,693
JBrowse link
G Plekhh3 pleckstrin homology, MyTH4 and FERM domain containing H3 increases expression ISO Irinotecan metabolite results in increased expression of PLEKHH3 mRNA; Irinotecan results in increased expression of PLEKHH3 mRNA CTD PMID:15956246 NCBI chr10:89,076,467...89,084,952
Ensembl chr10:89,076,472...89,084,885
JBrowse link
G Plk1 polo-like kinase 1 decreases expression ISO Irinotecan metabolite results in decreased expression of PLK1 mRNA; Irinotecan results in decreased expression of PLK1 mRNA CTD PMID:15956246 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Irinotecan metabolite results in increased expression of PLK2 mRNA; Irinotecan results in increased expression of PLK2 mRNA CTD PMID:15956246 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO Irinotecan metabolite results in increased expression of PLK3 mRNA; Irinotecan results in increased expression of PLK3 mRNA CTD PMID:15956246 NCBI chr 5:135,997,725...136,002,900
Ensembl chr 5:135,997,725...136,002,900
JBrowse link
G Plpp1 phospholipid phosphatase 1 decreases response to substance ISO PLPP1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:44,664,076...44,726,820
Ensembl chr 2:44,664,124...44,726,689
JBrowse link
G Plrg1 pleiotropic regulator 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of PLRG1 mRNA CTD PMID:16391804 NCBI chr 2:182,040,338...182,056,669
Ensembl chr 2:182,040,318...182,056,673
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Irinotecan metabolite results in increased expression of PMAIP1 mRNA; Irinotecan results in increased expression of PMAIP1 mRNA CTD PMID:15956246 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Pmp22 peripheral myelin protein 22 affects expression EXP Irinotecan affects the expression of PMP22 mRNA CTD PMID:20097248 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Pnrc1 proline-rich nuclear receptor coactivator 1 increases expression ISO Irinotecan analog results in increased expression of PNRC1 mRNA CTD PMID:18927307 NCBI chr 5:48,501,472...48,504,511
Ensembl chr 5:48,501,472...48,504,511
JBrowse link
G Pogz pogo transposable element derived with ZNF domain decreases expression ISO Irinotecan analog results in decreased expression of POGZ mRNA CTD PMID:18927307 NCBI chr 2:195,995,322...196,041,500
Ensembl chr 2:195,996,521...196,041,497
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit increases response to substance
affects expression
ISO
EXP
POLA1 protein results in increased susceptibility to Irinotecan
Irinotecan affects the expression of POLA1 mRNA
CTD PMID:16734730, PMID:20097248 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit increases response to substance ISO POLE2 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 6:91,494,348...91,532,355
Ensembl chr 6:91,494,393...91,518,996
JBrowse link
G Polk DNA polymerase kappa decreases expression ISO Irinotecan analog results in decreased expression of POLK mRNA CTD PMID:18927307 NCBI chr 2:27,305,718...27,364,906
Ensembl chr 2:27,305,728...27,364,906
JBrowse link
G Polr3g RNA polymerase III subunit G increases response to substance ISO POLR3G protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:9,537,642...9,578,551
Ensembl chr 2:9,537,642...9,578,310
JBrowse link
G Pon3 paraoxonase 3 affects expression EXP Irinotecan affects the expression of PON3 mRNA CTD PMID:20097248 NCBI chr 4:30,311,981...30,338,679
Ensembl chr 4:30,311,982...30,338,679
JBrowse link
G Por cytochrome p450 oxidoreductase increases response to substance ISO POR mRNA results in increased susceptibility to Irinotecan CTD PMID:15239142 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D increases expression ISO Irinotecan analog results in increased expression of PPM1D mRNA CTD PMID:18927307 NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha decreases expression
multiple interactions
ISO Irinotecan analog results in decreased expression of PPP3CA mRNA
[Fluorouracil co-treated with Irinotecan] results in increased expression of PPP3CA mRNA; PPP3CA protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:16391804, PMID:18927307 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta decreases expression ISO Irinotecan metabolite results in decreased expression of PPP3CB mRNA; Irinotecan results in decreased expression of PPP3CB mRNA CTD PMID:15956246 NCBI chr15:4,209,702...4,236,895
Ensembl chr15:4,209,703...4,236,895
JBrowse link
G Ppp4r3b protein phosphatase 4, regulatory subunit 3B decreases expression ISO Irinotecan analog results in decreased expression of PPP4R3B mRNA CTD PMID:18927307 NCBI chr14:113,570,150...113,618,138
Ensembl chr14:113,570,150...113,618,138
JBrowse link
G Prap1 proline-rich acidic protein 1 affects expression EXP Irinotecan affects the expression of PRAP1 mRNA CTD PMID:20097248 NCBI chr 1:212,558,257...212,562,053
Ensembl chr 1:212,558,257...212,562,051
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 decreases expression ISO Irinotecan analog results in decreased expression of PRKAA1 mRNA CTD PMID:18927307 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkca protein kinase C, alpha increases phosphorylation ISO Irinotecan metabolite results in increased phosphorylation of PRKCA protein; Irinotecan results in increased phosphorylation of PRKCA protein CTD PMID:15723263 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta increases phosphorylation ISO Irinotecan metabolite results in increased phosphorylation of PRKCB protein; Irinotecan results in increased phosphorylation of PRKCB protein CTD PMID:15723263 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta increases phosphorylation ISO Irinotecan metabolite results in increased phosphorylation of PRKCD protein; Irinotecan results in increased phosphorylation of PRKCD protein CTD PMID:15723263 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkci protein kinase C, iota increases phosphorylation ISO Irinotecan metabolite results in increased phosphorylation of PRKCI protein; Irinotecan results in increased phosphorylation of PRKCI protein CTD PMID:15723263 NCBI chr 2:115,941,998...116,002,550
Ensembl chr 2:115,941,993...116,002,561
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit multiple interactions
increases phosphorylation
ISO IC486241 inhibits the reaction [Irinotecan results in increased phosphorylation of PRKDC protein] CTD PMID:17441964, PMID:21221710 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Prlr prolactin receptor affects expression EXP Irinotecan affects the expression of PRLR mRNA CTD PMID:20097248 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link
G Prom1 prominin 1 decreases expression ISO Irinotecan metabolite results in decreased expression of PROM1 mRNA; Irinotecan results in decreased expression of PROM1 mRNA CTD PMID:15956246 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
JBrowse link
G Prr13 proline rich 13 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of PRR13 mRNA CTD PMID:16391804 NCBI chr 7:144,064,931...144,068,235
Ensembl chr 7:144,064,931...144,098,101
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases response to substance ISO PSAT1 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Ptch1 patched 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of PTCH1 mRNA CTD PMID:16391804 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Ptges prostaglandin E synthase increases expression ISO Irinotecan metabolite results in increased expression of PTGES mRNA; Irinotecan results in increased expression of PTGES mRNA CTD PMID:15956246 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Irinotecan results in increased expression of PTGS2 protein
carvacrol inhibits the reaction [Irinotecan results in increased expression of PTGS2 protein]
CTD PMID:27838229 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression ISO Irinotecan analog results in decreased expression of PTK2 mRNA CTD PMID:18927307 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 decreases expression ISO Irinotecan analog results in decreased expression of PTP4A1 mRNA CTD PMID:18927307 NCBI chr 9:37,223,363...37,254,222
Ensembl chr 9:37,223,729...37,231,291
JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 decreases expression ISO Irinotecan metabolite results in decreased expression of PTPN13 mRNA; Irinotecan results in decreased expression of PTPN13 mRNA CTD PMID:15956246 NCBI chr14:7,688,551...7,863,664
Ensembl chr14:7,688,551...7,863,664
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 increases expression ISO Irinotecan metabolite results in increased expression of PTPN22 mRNA; Irinotecan results in increased expression of PTPN22 mRNA CTD PMID:15956246 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D increases expression ISO Irinotecan metabolite results in increased expression of PTPRD mRNA; Irinotecan results in increased expression of PTPRD mRNA CTD PMID:15956246 NCBI chr 5:92,862,229...93,514,071
Ensembl chr 5:92,862,267...93,244,202
JBrowse link
G Ptprg protein tyrosine phosphatase, receptor type, G decreases expression ISO Irinotecan analog results in decreased expression of PTPRG mRNA CTD PMID:18927307 NCBI chr15:12,926,056...13,633,839
Ensembl chr15:12,926,167...13,228,607
JBrowse link
G Ptprn protein tyrosine phosphatase, receptor type, N increases expression ISO Irinotecan metabolite results in increased expression of PTPRN mRNA; Irinotecan results in increased expression of PTPRN mRNA CTD PMID:15956246 NCBI chr 9:82,446,626...82,462,314
Ensembl chr 9:82,446,633...82,461,903
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin affects expression EXP Irinotecan affects the expression of PTTG1 mRNA CTD PMID:20097248 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Rab27a RAB27A, member RAS oncogene family affects expression EXP Irinotecan affects the expression of RAB27A mRNA CTD PMID:20097248 NCBI chr 8:79,722,334...79,776,228
Ensembl chr 8:79,722,334...79,776,221
JBrowse link
G Rab31 RAB31, member RAS oncogene family decreases response to substance ISO RAB31 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 9:113,370,072...113,504,606
Ensembl chr 9:113,370,033...113,504,605
JBrowse link
G Rac3 Rac family small GTPase 3 increases expression ISO Irinotecan metabolite results in increased expression of RAC3 mRNA; Irinotecan results in increased expression of RAC3 mRNA CTD PMID:15956246 NCBI chr10:109,903,920...109,906,596
Ensembl chr10:109,904,259...109,906,232
JBrowse link
G Rad23b RAD23 homolog B, nucleotide excision repair protein decreases expression ISO Irinotecan metabolite results in decreased expression of RAD23B mRNA; Irinotecan results in decreased expression of RAD23B mRNA CTD PMID:15956246 NCBI chr 5:72,103,704...72,141,701
Ensembl chr 5:72,103,704...72,141,700
JBrowse link
G Rad51 RAD51 recombinase increases expression
multiple interactions
ISO Irinotecan results in increased expression of RAD51 protein
[Irinotecan co-treated with 2-(morpholin-4-yl)benzo(h)chromen-4-one] results in increased expression of RAD51 protein; [Irinotecan co-treated with IC486241] results in increased expression of RAD51 protein
CTD PMID:21221710 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Ramp1 receptor activity modifying protein 1 affects expression EXP Irinotecan affects the expression of RAMP1 mRNA CTD PMID:20097248 NCBI chr 9:98,313,632...98,364,206
Ensembl chr 9:98,313,632...98,364,205
JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression EXP Irinotecan results in increased expression of RARRES1 mRNA CTD PMID:20097248 NCBI chr 2:164,650,722...164,684,982
Ensembl chr 2:164,650,722...164,684,985
JBrowse link
G Rasa1 RAS p21 protein activator 1 decreases expression ISO Irinotecan analog results in decreased expression of RASA1 mRNA CTD PMID:18927307 NCBI chr 2:13,617,021...13,696,531
Ensembl chr 2:13,616,822...13,696,426
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects expression ISO Irinotecan affects the expression of RB1 protein CTD PMID:15132777 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit decreases expression
increases expression
ISO Irinotecan metabolite results in decreased expression of RBBP5 mRNA; Irinotecan results in decreased expression of RBBP5 mRNA
Irinotecan metabolite results in increased expression of RBBP5 mRNA; Irinotecan results in increased expression of RBBP5 mRNA
CTD PMID:15956246 NCBI chr13:49,250,301...49,277,152
Ensembl chr13:49,250,301...49,277,152
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO Irinotecan metabolite results in decreased expression of RBL1 mRNA; Irinotecan results in decreased expression of RBL1 mRNA CTD PMID:15956246 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352
JBrowse link
G Rbm24 RNA binding motif protein 24 increases expression ISO Irinotecan analog results in increased expression of RBM24 mRNA CTD PMID:18927307 NCBI chr17:18,671,037...18,682,876
Ensembl chr17:18,671,044...18,682,876
JBrowse link
G Rbms1 RNA binding motif, single stranded interacting protein 1 decreases response to substance ISO RBMS1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 3:46,802,870...47,025,178
Ensembl chr 3:46,803,355...47,025,128
JBrowse link
G Rbp2 retinol binding protein 2 affects expression EXP Irinotecan affects the expression of RBP2 mRNA CTD PMID:20097248 NCBI chr 8:106,479,253...106,527,726
Ensembl chr 8:106,503,504...106,527,711
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region multiple interactions
decreases expression
ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of RBPJ mRNA
Irinotecan analog results in decreased expression of RBPJ mRNA
CTD PMID:16391804, PMID:18927307 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs increases expression ISO Irinotecan analog results in increased expression of RECK mRNA CTD PMID:18927307 NCBI chr 5:59,348,568...59,415,169
Ensembl chr 5:59,348,639...59,415,135
JBrowse link
G Reg1a regenerating family member 1 alpha affects expression EXP Irinotecan affects the expression of REG1A mRNA CTD PMID:20097248 NCBI chr 4:109,497,962...109,500,626
Ensembl chr 4:109,497,962...109,501,082
JBrowse link
G Reg3b regenerating family member 3 beta affects expression EXP Irinotecan affects the expression of REG3B mRNA CTD PMID:20097248 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Reg3g regenerating family member 3 gamma affects expression EXP Irinotecan affects the expression of REG3G mRNA CTD PMID:20097248 NCBI chr 4:109,529,679...109,532,234
Ensembl chr 4:109,529,679...109,532,234
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression
increases activity
decreases response to substance
multiple interactions
EXP
ISO
Irinotecan results in increased expression of RELA protein
Irinotecan results in increased activity of RELA protein
RELA protein results in decreased susceptibility to Irinotecan
[Irinotecan co-treated with Thalidomide co-treated with Celecoxib] results in increased expression of RELA protein; [Irinotecan co-treated with Thalidomide] results in increased expression of RELA protein
CTD PMID:15161687, PMID:16685529, PMID:18182997, PMID:18535404 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Reps1 RALBP1 associated Eps domain containing 1 multiple interactions
decreases expression
ISO REPS1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
Irinotecan analog results in decreased expression of REPS1 mRNA
CTD PMID:18927307 NCBI chr 1:13,262,049...13,298,347
Ensembl chr 1:13,212,324...13,298,347
JBrowse link
G Rfc3 replication factor C subunit 3 increases response to substance
decreases expression
ISO RFC3 protein results in increased susceptibility to Irinotecan
Irinotecan metabolite results in decreased expression of RFC3 mRNA; Irinotecan results in decreased expression of RFC3 mRNA
CTD PMID:15956246, PMID:16734730 NCBI chr12:1,460,581...1,471,344
Ensembl chr12:1,460,538...1,471,357
JBrowse link
G RGD1308706 similar to RIKEN cDNA 4921524J17 decreases expression ISO Irinotecan analog results in decreased expression of C16ORF87 mRNA CTD PMID:18927307 NCBI chr19:22,699,808...22,726,712
Ensembl chr19:22,699,808...22,726,701
JBrowse link
G RGD1563323 similar to hypothetical protein FLJ22531 increases expression ISO Irinotecan analog results in increased expression of C11ORF80 mRNA CTD PMID:18927307 NCBI chr 1:219,864,108...219,952,143 JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO Irinotecan metabolite results in increased expression of RGS1 mRNA; Irinotecan results in increased expression of RGS1 mRNA CTD PMID:15956246 NCBI chr13:61,066,196...61,070,772
Ensembl chr13:61,066,153...61,070,599
JBrowse link
G Rgs22 regulator of G-protein signaling 22 decreases expression ISO Irinotecan analog results in decreased expression of RGS22 mRNA CTD PMID:18927307 NCBI chr 7:74,783,009...74,902,049
Ensembl chr 7:74,783,019...74,901,997
JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression EXP Irinotecan results in increased expression of RGS4 mRNA CTD PMID:20097248 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rhob ras homolog family member B increases expression ISO Irinotecan results in increased expression of RHOB mRNA CTD PMID:20185912 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Rhou ras homolog family member U increases expression ISO Irinotecan analog results in increased expression of RHOU mRNA CTD PMID:18927307 NCBI chr19:56,431,787...56,443,896
Ensembl chr19:56,435,577...56,441,733
JBrowse link
G Rlim ring finger protein, LIM domain interacting decreases expression ISO Irinotecan analog results in decreased expression of RLIM mRNA CTD PMID:18927307 NCBI chr  X:73,757,664...73,778,763
Ensembl chr  X:73,762,691...73,778,674
Ensembl chr  X:73,762,691...73,778,674
JBrowse link
G Rnf34 ring finger protein 34 multiple interactions
decreases response to substance
ISO RNF34 protein inhibits the reaction [Irinotecan results in increased activity of CASP3 protein]
RNF34 protein results in decreased susceptibility to Irinotecan
CTD PMID:16080519 NCBI chr12:39,164,290...39,185,209
Ensembl chr12:39,164,290...39,185,168
JBrowse link
G Rpl4 ribosomal protein L4 decreases expression ISO Irinotecan analog results in decreased expression of RPL4 mRNA CTD PMID:18927307 NCBI chr 8:69,121,682...69,126,805
Ensembl chr 8:69,121,682...69,126,805
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [Irinotecan co-treated with rucaparib] results in decreased expression of RPS6KB1 protein CTD PMID:30612311 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases expression ISO Irinotecan analog results in increased expression of HLA-DRB1 mRNA CTD PMID:18927307 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G Rtp4 receptor (chemosensory) transporter protein 4 affects expression EXP Irinotecan affects the expression of RTP4 mRNA CTD PMID:20097248 NCBI chr11:80,638,945...80,650,802
Ensembl chr11:80,638,945...80,650,802
JBrowse link
G Runx1 RUNX family transcription factor 1 decreases expression ISO Irinotecan metabolite results in decreased expression of RUNX1 mRNA; Irinotecan results in decreased expression of RUNX1 mRNA CTD PMID:15956246 NCBI chr11:32,765,147...33,003,061
Ensembl chr11:32,769,165...33,003,021
JBrowse link
G S100g S100 calcium binding protein G affects expression EXP Irinotecan affects the expression of S100G mRNA CTD PMID:20097248 NCBI chr  X:33,442,820...33,445,714
Ensembl chr  X:33,443,186...33,445,709
JBrowse link
G Samd9 sterile alpha motif domain containing 9 increases expression ISO Irinotecan analog results in increased expression of SAMD9 mRNA CTD PMID:18927307 NCBI chr 4:28,304,967...28,324,637
Ensembl chr 4:28,305,002...28,310,178
JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 affects expression ISO Irinotecan analog affects the expression of SAMHD1 mRNA CTD PMID:18927307 NCBI chr 3:153,210,829...153,250,705
Ensembl chr 3:153,210,829...153,250,641
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 decreases response to substance
increases expression
ISO SAT1 mRNA results in decreased susceptibility to Irinotecan
Irinotecan results in increased expression of SAT1 mRNA
CTD PMID:15152939 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Scaf4 SR-related CTD-associated factor 4 decreases expression ISO Irinotecan analog results in decreased expression of SCAF4 mRNA CTD PMID:18927307 NCBI chr11:30,371,713...30,428,073
Ensembl chr11:30,371,713...30,428,073
JBrowse link
G Scai suppressor of cancer cell invasion decreases expression ISO Irinotecan analog results in decreased expression of SCAI mRNA CTD PMID:18927307 NCBI chr 3:23,357,586...23,474,218
Ensembl chr 3:23,362,707...23,474,170
JBrowse link
G Scamp3 secretory carrier membrane protein 3 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of SCAMP3 mRNA CTD PMID:16391804 NCBI chr 2:188,488,907...188,495,147
Ensembl chr 2:188,476,820...188,496,191
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Irinotecan analog results in increased expression of SCD4 mRNA CTD PMID:18927307 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scin scinderin affects expression EXP Irinotecan affects the expression of SCIN mRNA CTD PMID:20097248 NCBI chr 6:59,975,375...60,055,075
Ensembl chr 6:59,976,003...60,054,279
JBrowse link
G Sdc4 syndecan 4 increases expression ISO Irinotecan metabolite results in increased expression of SDC4 mRNA; Irinotecan results in increased expression of SDC4 mRNA CTD PMID:15956246 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190
JBrowse link
G Sec31a SEC31 homolog A, COPII coat complex component decreases expression ISO Irinotecan analog results in decreased expression of SEC31A mRNA CTD PMID:18927307 NCBI chr14:10,854,713...10,909,579
Ensembl chr14:10,854,682...10,909,612
JBrowse link
G Sema3c semaphorin 3C increases expression ISO Irinotecan analog results in increased expression of SEMA3C mRNA CTD PMID:18927307 NCBI chr 4:14,318,276...14,490,438
Ensembl chr 4:14,318,274...14,490,446
JBrowse link
G Senp6 SUMO specific peptidase 6 decreases expression ISO Irinotecan analog results in decreased expression of SENP6 mRNA CTD PMID:18927307 NCBI chr 8:87,486,050...87,568,088
Ensembl chr 8:87,486,427...87,563,652
JBrowse link
G Serpinb5 serpin family B member 5 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of SERPINB5 mRNA CTD PMID:16391804 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO SERPINE2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Sertad1 SERTA domain containing 1 increases expression ISO Irinotecan results in increased expression of SERTAD1 mRNA CTD PMID:20185912 NCBI chr 1:84,293,102...84,296,370
Ensembl chr 1:84,293,102...84,296,367
JBrowse link
G Sesn2 sestrin 2 increases expression ISO Irinotecan metabolite results in increased expression of SESN2 mRNA; Irinotecan results in increased expression of SESN2 mRNA CTD PMID:15956246 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Setd1b SET domain containing 1B, histone lysine methyltransferase decreases expression ISO Irinotecan analog results in decreased expression of SETD1B mRNA CTD PMID:18927307 NCBI chr12:38,843,167...38,869,180
Ensembl chr12:38,845,621...38,869,346
JBrowse link
G Setd5 SET domain containing 5 decreases expression ISO Irinotecan analog results in decreased expression of SETD5 mRNA CTD PMID:18927307 NCBI chr 4:145,017,549...145,095,247
Ensembl chr 4:145,017,608...145,095,245
JBrowse link
G Sfn stratifin multiple interactions ISO [Irinotecan co-treated with Bortezomib] results in decreased expression of SFN protein CTD PMID:16373703 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Irinotecan analog results in increased expression of SGK1 mRNA; Irinotecan metabolite results in increased expression of SGK1 mRNA; Irinotecan results in increased expression of SGK1 mRNA CTD PMID:15956246, PMID:18927307, PMID:20185912 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Sgo2 shugoshin 2 decreases expression ISO Irinotecan analog results in decreased expression of SGO2 mRNA CTD PMID:18927307 NCBI chr 9:64,898,380...64,923,023
Ensembl chr 9:64,898,459...64,923,012
JBrowse link
G Siglec1 sialic acid binding Ig like lectin 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of SIGLEC1 mRNA CTD PMID:16391804 NCBI chr 3:123,612,067...123,631,718
Ensembl chr 3:123,612,067...123,631,109
JBrowse link
G Skp2 S-phase kinase associated protein 2 increases response to substance ISO SKP2 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:58,506,146...58,534,211
Ensembl chr 2:58,506,151...58,534,211
JBrowse link
G Slc13a2 solute carrier family 13 member 2 affects expression EXP Irinotecan affects the expression of SLC13A2 mRNA CTD PMID:20097248 NCBI chr10:65,664,665...65,692,046
Ensembl chr10:65,664,667...65,692,023
JBrowse link
G Slc16a4 solute carrier family 16, member 4 decreases expression ISO Irinotecan metabolite results in decreased expression of SLC16A4 mRNA; Irinotecan results in decreased expression of SLC16A4 mRNA CTD PMID:15956246 NCBI chr 2:210,045,122...210,161,017
Ensembl chr 2:210,045,161...210,068,502
JBrowse link
G Slc19a1 solute carrier family 19 member 1 decreases expression ISO Irinotecan analog results in decreased expression of SLC19A1 mRNA CTD PMID:18927307 NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377
JBrowse link
G Slc25a21 solute carrier family 25 member 21 decreases expression ISO Irinotecan analog results in decreased expression of SLC25A21 mRNA CTD PMID:18927307 NCBI chr 6:77,624,384...78,121,339
Ensembl chr 6:77,624,385...77,848,434
JBrowse link
G Slc25a36 solute carrier family 25 member 36 affects expression EXP Irinotecan affects the expression of SLC25A36 mRNA CTD PMID:20097248 NCBI chr 8:104,962,569...104,995,935
Ensembl chr 8:104,966,124...104,995,725
JBrowse link
G Slc30a1 solute carrier family 30 member 1 decreases expression ISO Irinotecan analog results in decreased expression of SLC30A1 mRNA CTD PMID:18927307 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
JBrowse link
G Slc31a1 solute carrier family 31 member 1 affects expression EXP Irinotecan affects the expression of SLC31A1 mRNA CTD PMID:20097248 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Slc39a4 solute carrier family 39 member 4 affects expression EXP Irinotecan affects the expression of SLC39A4 mRNA CTD PMID:20097248 NCBI chr 7:117,675,718...117,682,586
Ensembl chr 7:117,675,720...117,680,004
JBrowse link
G Slc44a1 solute carrier family 44 member 1 affects expression EXP Irinotecan affects the expression of SLC44A1 mRNA CTD PMID:20097248 NCBI chr 5:70,243,643...70,424,115
Ensembl chr 5:70,245,843...70,424,112
JBrowse link
G Slc9a3r2 SLC9A3 regulator 2 increases expression ISO Irinotecan metabolite results in increased expression of SLC9A3R2 mRNA; Irinotecan results in increased expression of SLC9A3R2 mRNA CTD PMID:15956246 NCBI chr10:14,003,330...14,015,066
Ensembl chr10:14,003,320...14,013,870
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Irinotecan inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor affects expression EXP Irinotecan affects the expression of SLPI mRNA CTD PMID:20097248 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link
G Smad3 SMAD family member 3 decreases expression ISO Irinotecan analog results in decreased expression of SMAD3 mRNA CTD PMID:18927307 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 decreases expression ISO Irinotecan analog results in decreased expression of SMCHD1 mRNA CTD PMID:18927307 NCBI chr 9:119,675,750...119,818,620
Ensembl chr 9:119,676,628...119,818,310
JBrowse link
G Smu1 SMU1, DNA replication regulator and spliceosomal factor decreases expression ISO Irinotecan analog results in decreased expression of SMU1 mRNA CTD PMID:18927307 NCBI chr 5:57,042,301...57,061,379
Ensembl chr 5:57,042,705...57,061,365
JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 affects expression ISO Irinotecan analog affects the expression of SMURF1 mRNA CTD PMID:18927307 NCBI chr12:11,433,815...11,526,465
Ensembl chr12:11,407,213...11,526,465
JBrowse link
G Snrpa1 small nuclear ribonucleoprotein polypeptide A' multiple interactions
decreases expression
ISO SNRPA1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
Irinotecan analog results in decreased expression of SNRPA1 mRNA
CTD PMID:18927307 NCBI chr 1:126,961,389...126,974,453
Ensembl chr 1:126,961,389...126,974,453
JBrowse link
G Snrpf small nuclear ribonucleoprotein polypeptide F increases response to substance ISO SNRPF protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 7:34,478,331...34,485,034
Ensembl chr 7:34,478,331...34,485,034
JBrowse link
G Snx18 sorting nexin 18 decreases expression ISO Irinotecan metabolite results in decreased expression of SNX18 mRNA; Irinotecan results in decreased expression of SNX18 mRNA CTD PMID:15956246 NCBI chr 2:45,454,782...45,480,798
Ensembl chr 2:45,454,782...45,480,798
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Irinotecan co-treated with Fluorouracil] results in increased activity of SOD2 protein CTD PMID:15886469 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sp1 Sp1 transcription factor decreases expression
increases phosphorylation
multiple interactions
ISO Irinotecan analog results in decreased expression of SP1 mRNA
Irinotecan results in increased phosphorylation of SP1 protein
SP1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:17441964, PMID:18927307 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sphk1 sphingosine kinase 1 affects expression EXP Irinotecan affects the expression of SPHK1 mRNA CTD PMID:20097248 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Spib Spi-B transcription factor increases expression ISO Irinotecan metabolite results in increased expression of SPIB mRNA; Irinotecan results in increased expression of SPIB mRNA CTD PMID:15956246 NCBI chr 1:100,531,538...100,537,397
Ensembl chr 1:100,531,457...100,537,377
JBrowse link
G Srp19 signal recognition particle 19 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of SRP19 mRNA CTD PMID:16391804 NCBI chr18:27,114,822...27,121,062
Ensembl chr18:27,114,822...27,121,059
JBrowse link
G Srpx sushi-repeat-containing protein, X-linked increases expression EXP Irinotecan results in increased expression of SRPX mRNA CTD PMID:20097248 NCBI chr  X:14,146,618...14,220,756
Ensembl chr  X:14,150,038...14,220,662
JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases phosphorylation
multiple interactions
ISO Irinotecan results in increased phosphorylation of STAT1 protein
STAT1 protein promotes the reaction [Irinotecan results in increased localization of FAS protein]; TP53 protein inhibits the reaction [Irinotecan results in increased phosphorylation of STAT1 protein]
CTD PMID:16204068 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stk25 serine/threonine kinase 25 affects expression EXP Irinotecan affects the expression of STK25 mRNA CTD PMID:20097248 NCBI chr 9:100,767,578...100,779,715
Ensembl chr 9:100,767,579...100,779,715
JBrowse link
G Stk38 serine/threonine kinase 38 increases expression ISO Irinotecan metabolite results in increased expression of STK38 mRNA; Irinotecan results in increased expression of STK38 mRNA CTD PMID:15956246 NCBI chr20:6,224,300...6,257,613
Ensembl chr20:6,224,296...6,257,604
JBrowse link
G Stk4 serine/threonine kinase 4 decreases expression
multiple interactions
ISO Irinotecan analog results in decreased expression of STK4 mRNA; Irinotecan metabolite results in decreased expression of STK4 mRNA; Irinotecan results in decreased expression of STK4 mRNA
STK4 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:15956246, PMID:18927307 NCBI chr 3:160,467,552...160,546,540
Ensembl chr 3:160,467,552...160,546,540
JBrowse link
G Stx5 syntaxin 5 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of STX5 mRNA CTD PMID:16391804 NCBI chr 1:224,939,497...224,955,658
Ensembl chr 1:224,939,497...224,955,657
JBrowse link
G Syde2 synapse defective Rho GTPase homolog 2 increases expression ISO Irinotecan analog results in increased expression of SYDE2 mRNA CTD PMID:18927307 NCBI chr 2:251,861,900...251,895,524
Ensembl chr 2:251,863,069...251,894,037
JBrowse link
G Syt1 synaptotagmin 1 decreases expression ISO Irinotecan analog results in decreased expression of SYT1 mRNA CTD PMID:18927307 NCBI chr 7:50,084,063...50,638,996
Ensembl chr 7:50,084,060...50,638,798
JBrowse link
G Taf2 TATA-box binding protein associated factor 2 decreases expression ISO Irinotecan metabolite results in decreased expression of TAF2 mRNA; Irinotecan results in decreased expression of TAF2 mRNA CTD PMID:15956246 NCBI chr 7:94,698,987...94,755,924
Ensembl chr 7:94,698,987...94,755,924
JBrowse link
G Taf5l TATA-box binding protein associated factor 5 like multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of TAF5L mRNA CTD PMID:16391804 NCBI chr19:56,781,854...56,801,005
Ensembl chr19:56,781,859...56,799,445
JBrowse link
G Tbcc tubulin folding cofactor C increases expression ISO Irinotecan metabolite results in increased expression of TBCC mRNA; Irinotecan results in increased expression of TBCC mRNA CTD PMID:15956246, PMID:20185912 NCBI chr 9:16,405,187...16,406,338
Ensembl chr 9:16,405,185...16,406,338
JBrowse link
G Tcf12 transcription factor 12 decreases expression ISO Irinotecan analog results in decreased expression of TCF12 mRNA CTD PMID:18927307 NCBI chr 8:78,343,634...78,657,738
Ensembl chr 8:78,345,754...78,655,856
JBrowse link
G Tcf7l2 transcription factor 7 like 2 decreases expression ISO Irinotecan analog results in decreased expression of TCF7L2 mRNA CTD PMID:18927307 NCBI chr 1:276,686,911...276,730,517
Ensembl chr 1:276,659,542...276,730,514
Ensembl chr 1:276,659,542...276,730,514
JBrowse link
G Tesk2 testis associated actin remodelling kinase 2 affects expression EXP Irinotecan affects the expression of TESK2 mRNA CTD PMID:20097248 NCBI chr 5:135,574,172...135,659,842
Ensembl chr 5:135,574,172...135,659,842
JBrowse link
G Tfcp2 transcription factor CP2 decreases expression ISO Irinotecan analog results in decreased expression of TFCP2 mRNA CTD PMID:18927307 NCBI chr 7:142,138,836...142,181,036
Ensembl chr 7:142,138,844...142,180,997
JBrowse link
G Tff1 trefoil factor 1 affects expression EXP Irinotecan affects the expression of TFF1 mRNA CTD PMID:20097248 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tff3 trefoil factor 3 affects expression EXP Irinotecan affects the expression of TFF3 mRNA CTD PMID:20097248 NCBI chr20:9,850,800...9,855,481
Ensembl chr20:9,850,803...9,855,481
JBrowse link
G Tfpi tissue factor pathway inhibitor decreases expression ISO Irinotecan analog results in decreased expression of TFPI mRNA CTD PMID:18927307 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
G Tfrc transferrin receptor increases expression ISO Irinotecan analog results in increased expression of TFRC mRNA CTD PMID:18927307 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions
increases secretion
decreases response to substance
ISO Gefitinib inhibits the reaction [Irinotecan metabolite results in increased secretion of TGFA protein]; Gefitinib inhibits the reaction [Irinotecan results in increased secretion of TGFA protein]; rottlerin inhibits the reaction [Irinotecan metabolite results in increased secretion of TGFA protein]; rottlerin inhibits the reaction [Irinotecan results in increased secretion of TGFA protein]
Irinotecan metabolite results in increased secretion of TGFA protein; Irinotecan results in increased secretion of TGFA protein
TGFA protein results in decreased susceptibility to Irinotecan
CTD PMID:15723263, PMID:16734730 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tgfbi transforming growth factor, beta induced decreases expression ISO Irinotecan analog results in decreased expression of TGFBI mRNA CTD PMID:18927307 NCBI chr17:8,400,123...8,429,338
Ensembl chr17:8,400,146...8,429,338
JBrowse link
G Thbs1 thrombospondin 1 decreases response to substance ISO THBS1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Thbs2 thrombospondin 2 increases expression EXP Irinotecan results in increased expression of THBS2 mRNA CTD PMID:20097248 NCBI chr 1:56,653,929...56,683,571
Ensembl chr 1:56,653,938...56,683,731
JBrowse link
G Them4 thioesterase superfamily member 4 decreases expression ISO Irinotecan analog results in decreased expression of THEM4 mRNA CTD PMID:18927307 NCBI chr 2:195,554,092...195,576,710
Ensembl chr 2:195,553,971...195,577,680
JBrowse link
G Thnsl1 threonine synthase-like 1 decreases expression ISO Irinotecan analog results in decreased expression of THNSL1 mRNA CTD PMID:18927307 NCBI chr17:88,095,830...88,102,264
Ensembl chr17:88,095,830...88,102,262
JBrowse link
G Thrap3 thyroid hormone receptor associated protein 3 decreases expression ISO Irinotecan analog results in decreased expression of THRAP3 mRNA CTD PMID:18927307 NCBI chr 5:144,178,248...144,221,318
Ensembl chr 5:144,179,023...144,221,263
JBrowse link
G Thy1 Thy-1 cell surface antigen increases expression ISO Irinotecan metabolite results in increased expression of THY1 mRNA; Irinotecan results in increased expression of THY1 mRNA CTD PMID:15956246 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions
ISO Irinotecan results in increased expression of TLR4 protein
Silymarin inhibits the reaction [Irinotecan results in increased expression of TLR4 protein]
CTD PMID:28454924 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tmem123 transmembrane protein 123 decreases expression ISO Irinotecan analog results in decreased expression of TMEM123 mRNA CTD PMID:18927307 NCBI chr 8:5,967,373...5,997,387
Ensembl chr 8:5,967,463...5,997,383
JBrowse link
G Tmem267 transmembrane protein 267 decreases expression ISO Irinotecan analog results in decreased expression of TMEM267 mRNA CTD PMID:18927307 NCBI chr 2:52,356,449...52,366,075
Ensembl chr 2:52,358,097...52,366,667
JBrowse link
G Tmem37 transmembrane protein 37 affects expression EXP Irinotecan affects the expression of TMEM37 mRNA CTD PMID:20097248 NCBI chr13:36,094,665...36,101,443
Ensembl chr13:36,094,520...36,101,411
JBrowse link
G Tmem41b transmembrane protein 41B decreases expression ISO Irinotecan metabolite results in decreased expression of TMEM41B mRNA; Irinotecan results in decreased expression of TMEM41B mRNA CTD PMID:15956246 NCBI chr 1:174,605,833...174,620,192
Ensembl chr 1:174,605,834...174,620,064
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
[Irinotecan co-treated with Ciprofloxacin] promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ciprofloxacin inhibits the reaction [Irinotecan promotes the reaction [Mitogens results in increased expression of TNF protein]]; Irinotecan inhibits the reaction [Mitogens results in increased expression of TNF protein]; Irinotecan promotes the reaction [Mitogens results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of TNF protein]
Irinotecan results in increased expression of TNF mRNA; Irinotecan results in increased expression of TNF protein
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [Irinotecan results in increased expression of TNF protein]]; carvacrol inhibits the reaction [Irinotecan results in increased expression of TNF protein]
CTD PMID:16815871, PMID:18182997, PMID:18535404, PMID:19401694, PMID:26431797, PMID:27838229 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO Irinotecan metabolite results in decreased expression of TNFAIP6 mRNA; Irinotecan results in decreased expression of TNFAIP6 mRNA CTD PMID:15956246 NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression EXP Irinotecan results in increased expression of TNFRSF12A mRNA CTD PMID:20097248 NCBI chr10:12,995,904...12,997,930
Ensembl chr10:12,995,904...12,997,930
JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 affects expression EXP Irinotecan affects the expression of TNFRSF14 mRNA CTD PMID:20097248 NCBI chr 5:172,328,259...172,337,221
Ensembl chr 5:172,328,262...172,335,892
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Irinotecan results in increased expression of TNFRSF1A mRNA CTD PMID:20097248 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases activity
ISO CFLAR protein alternative form inhibits the reaction [Irinotecan results in increased activity of TNFSF10 protein] CTD PMID:16373718 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tob1 transducer of ErbB-2.1 increases expression ISO Irinotecan metabolite results in increased expression of TOB1 mRNA; Irinotecan results in increased expression of TOB1 mRNA CTD PMID:15956246 NCBI chr10:81,913,689...81,915,727
Ensembl chr10:81,913,689...81,915,716
JBrowse link
G Tob2 transducer of ERBB2, 2 increases expression ISO Irinotecan metabolite results in increased expression of TOB2 mRNA; Irinotecan results in increased expression of TOB2 mRNA CTD PMID:15956246 NCBI chr 7:123,079,520...123,088,240
Ensembl chr 7:123,079,537...123,088,279
JBrowse link
G Top1 DNA topoisomerase I decreases activity
affects response to substance
affects binding
ISO Irinotecan results in decreased activity of TOP1 protein
TOP1 protein affects the susceptibility to Irinotecan
Irinotecan binds to TOP1 protein
CTD PMID:11914913, PMID:15041737, PMID:15655543, PMID:18509181 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Top2a DNA topoisomerase II alpha increases response to substance
decreases expression
ISO TOP2A mRNA results in increased susceptibility to Irinotecan
Irinotecan metabolite results in decreased expression of TOP2A mRNA; Irinotecan results in decreased expression of TOP2A mRNA
CTD PMID:15239142, PMID:15956246 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase decreases expression ISO Irinotecan metabolite results in decreased expression of TOPORS mRNA; Irinotecan results in decreased expression of TOPORS mRNA CTD PMID:15956246 NCBI chr 5:56,554,956...56,566,503
Ensembl chr 5:56,554,969...56,567,320
JBrowse link
G Tp53 tumor protein p53 increases expression
affects response to substance
increases phosphorylation
multiple interactions
increases response to substance
ISO Irinotecan results in increased expression of TP53 mRNA; Irinotecan results in increased expression of TP53 protein
TP53 protein affects the susceptibility to Irinotecan
Irinotecan results in increased phosphorylation of TP53 protein
[Irinotecan co-treated with Bortezomib] results in increased ubiquitination of TP53 protein; Irinotecan results in increased phosphorylation of and results in increased activity of TP53 protein; Irinotecan results in increased phosphorylation of and results in increased expression of TP53 protein; TP53 protein affects the susceptibility to [Irinotecan co-treated with Bortezomib]; TP53 protein inhibits the reaction [Irinotecan results in increased phosphorylation of STAT1 protein]
TP53 results in increased susceptibility to Irinotecan
CTD PMID:16204068, PMID:16373703, PMID:16963839, PMID:22510560, PMID:22898888 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Irinotecan analog results in increased expression of TP53INP1 mRNA CTD PMID:18927307 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Tpmt thiopurine S-methyltransferase increases expression
multiple interactions
ISO Irinotecan analog results in increased expression of TPMT mRNA
TPMT protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:18927307 NCBI chr17:18,029,090...18,047,716
Ensembl chr17:18,029,124...18,047,714
JBrowse link
G Tppp tubulin polymerization promoting protein increases expression ISO Irinotecan analog results in increased expression of TPPP mRNA CTD PMID:18927307 NCBI chr 1:31,866,755...31,890,778
Ensembl chr 1:31,870,899...31,890,778
JBrowse link
G Tpx2 TPX2, microtubule nucleation factor decreases expression ISO Irinotecan metabolite results in decreased expression of TPX2 mRNA; Irinotecan results in decreased expression of TPX2 mRNA CTD PMID:15956246 NCBI chr 3:148,327,965...148,370,187
Ensembl chr 3:148,327,965...148,370,187
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO Irinotecan metabolite results in increased expression of TRADD mRNA; Irinotecan results in increased expression of TRADD mRNA CTD PMID:15956246 NCBI chr19:37,214,461...37,221,099
Ensembl chr19:37,214,471...37,216,572
JBrowse link
G Traf1 TNF receptor-associated factor 1 decreases expression
increases expression
ISO Irinotecan metabolite results in decreased expression of TRAF1 mRNA; Irinotecan results in decreased expression of TRAF1 mRNA
Irinotecan metabolite results in increased expression of TRAF1 mRNA; Irinotecan results in increased expression of TRAF1 mRNA
CTD PMID:15956246 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 decreases expression ISO Irinotecan metabolite results in decreased expression of TRDMT1 mRNA; Irinotecan results in decreased expression of TRDMT1 mRNA CTD PMID:15956246 NCBI chr17:80,824,652...80,859,585
Ensembl chr17:80,826,846...80,860,195
JBrowse link
G Trib1 tribbles pseudokinase 1 increases expression ISO Irinotecan analog results in increased expression of TRIB1 mRNA CTD PMID:18927307 NCBI chr 7:99,954,492...99,961,026
Ensembl chr 7:99,954,492...99,961,026
JBrowse link
G Trib2 tribbles pseudokinase 2 affects expression ISO Irinotecan analog affects the expression of TRIB2 mRNA CTD PMID:18927307 NCBI chr 6:41,016,722...41,040,972
Ensembl chr 6:41,016,730...41,039,437
JBrowse link
G Trim9 tripartite motif-containing 9 increases expression ISO Irinotecan analog results in increased expression of TRIM9 mRNA CTD PMID:18927307 NCBI chr 6:92,660,026...92,760,036
Ensembl chr 6:92,660,505...92,760,018
JBrowse link
G Trmt13 tRNA methyltransferase 13 homolog decreases expression ISO Irinotecan analog results in decreased expression of TRMT13 mRNA CTD PMID:18927307 NCBI chr 2:219,615,665...219,628,824
Ensembl chr 2:219,615,420...219,628,997
JBrowse link
G Tsen2 tRNA splicing endonuclease subunit 2 decreases expression ISO Irinotecan results in decreased expression of TSEN2 mRNA CTD PMID:20185912 NCBI chr 4:147,455,506...147,490,869
Ensembl chr 4:147,455,533...147,490,733
JBrowse link
G Tspan4 tetraspanin 4 increases expression EXP Irinotecan results in increased expression of TSPAN4 mRNA CTD PMID:20097248 NCBI chr 1:214,454,090...214,473,789
Ensembl chr 1:214,454,090...214,473,741
JBrowse link
G Tspan8 tetraspanin 8 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of TSPAN8 mRNA CTD PMID:16391804 NCBI chr 7:58,814,805...58,847,564
Ensembl chr 7:58,814,805...58,847,563
JBrowse link
G Ttk Ttk protein kinase decreases expression ISO Irinotecan metabolite results in decreased expression of TTK mRNA; Irinotecan results in decreased expression of TTK mRNA CTD PMID:15956246 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Irinotecan results in increased expression of TXNIP mRNA CTD PMID:20185912 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Txnrd1 thioredoxin reductase 1 affects expression EXP Irinotecan affects the expression of TXNRD1 mRNA CTD PMID:20097248 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO TYMP mRNA affects the susceptibility to [Irinotecan co-treated with Fluorouracil co-treated with Leucovorin] CTD PMID:17454858 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO TYMS mRNA affects the susceptibility to [Irinotecan co-treated with Fluorouracil co-treated with Leucovorin] CTD PMID:17454858 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Ubd ubiquitin D affects expression EXP Irinotecan affects the expression of UBD mRNA CTD PMID:20097248 NCBI chr20:1,876,175...1,878,126
Ensembl chr20:1,876,173...1,897,814
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO
EXP
Irinotecan metabolite results in decreased expression of UBE2C mRNA; Irinotecan results in decreased expression of UBE2C mRNA CTD PMID:15956246, PMID:20097248 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Ube2e3 ubiquitin-conjugating enzyme E2E 3 decreases expression ISO Irinotecan analog results in decreased expression of UBE2E3 mRNA CTD PMID:18927307 NCBI chr 3:65,815,076...65,876,256
Ensembl chr 3:65,815,080...65,871,363
JBrowse link
G Ube2j2 ubiquitin-conjugating enzyme E2, J2 decreases expression ISO Irinotecan analog results in decreased expression of UBE2J2 mRNA CTD PMID:18927307 NCBI chr 5:173,372,659...173,387,084
Ensembl chr 5:173,372,669...173,387,104
JBrowse link
G Ube2l6 ubiquitin-conjugating enzyme E2L 6 affects expression EXP Irinotecan affects the expression of UBE2L6 mRNA CTD PMID:20097248 NCBI chr 3:72,191,533...72,206,190
Ensembl chr 3:72,191,533...72,206,188
JBrowse link
G Uchl5 ubiquitin C-terminal hydrolase L5 decreases expression ISO Irinotecan metabolite results in decreased expression of UCHL5 mRNA; Irinotecan results in decreased expression of UCHL5 mRNA CTD PMID:15956246 NCBI chr13:60,568,102...60,603,812
Ensembl chr13:60,545,635...60,603,811
JBrowse link
G Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 decreases expression ISO Irinotecan analog results in decreased expression of UGGT2 mRNA CTD PMID:18927307 NCBI chr15:104,235,678...104,405,308 JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects response to substance
decreases glucuronidation
increases glucuronidation
increases metabolic processing
affects metabolic processing
multiple interactions
ISO
EXP
UGT1A1 gene polymorphism affects the susceptibility to Irinotecan; UGT1A1 promoter polymorphism affects the susceptibility to Irinotecan; UGT1A1 protein affects the susceptibility to Irinotecan
UGT1A1 gene mutant form results in decreased glucuronidation of Irinotecan; UGT1A1 protein polymorphism results in decreased glucuronidation of Irinotecan
UGT1A1 protein results in increased glucuronidation of Irinotecan
UGT1A1 protein results in increased metabolism of Irinotecan
UGT1A1 protein affects the metabolism of Irinotecan
[Ketoconazole results in decreased activity of UGT1A1 protein] which results in decreased metabolism of Irinotecan; UGT1A1 gene polymorphism affects the susceptibility to [Fluorouracil co-treated with Irinotecan]; UGT1A1 protein results in increased glucuronidation of and results in decreased activity of Irinotecan
CTD PMID:12960109, PMID:15517893, PMID:15523087, PMID:15655543, PMID:15716465, PMID:15833930, PMID:15858133, PMID:17898154, PMID:18300238, PMID:18478930, PMID:18797458, PMID:22447115, PMID:23401472 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Irinotecan CTD PMID:15716465 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Irinotecan CTD PMID:15833930 NCBI chr 9:95,233,957...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO
EXP
UGT1A8 protein results in increased glucuronidation of Irinotecan CTD PMID:15833930, PMID:17898154 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO
EXP
UGT1A9 protein results in increased glucuronidation of Irinotecan CTD PMID:15833930, PMID:17898154 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ulk4 unc-51 like kinase 4 decreases expression ISO Irinotecan analog results in decreased expression of ULK4 mRNA CTD PMID:18927307 NCBI chr 8:129,631,003...129,919,080
Ensembl chr 8:129,632,149...129,919,120
JBrowse link
G Uso1 USO1 vesicle transport factor decreases expression ISO Irinotecan analog results in decreased expression of USO1 mRNA CTD PMID:18927307 NCBI chr14:17,371,451...17,436,948
Ensembl chr14:17,371,453...17,436,897
JBrowse link
G Usp24 ubiquitin specific peptidase 24 decreases expression ISO Irinotecan analog results in decreased expression of USP24 mRNA CTD PMID:18927307 NCBI chr 5:125,896,725...126,030,411
Ensembl chr 5:125,896,725...126,030,401
JBrowse link
G Utp3 UTP3, small subunit processome component multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of UTP3 mRNA CTD PMID:16391804 NCBI chr14:21,153,998...21,155,652
Ensembl chr14:21,154,000...21,155,652
JBrowse link
G Vldlr very low density lipoprotein receptor affects expression EXP Irinotecan affects the expression of VLDLR mRNA CTD PMID:20097248 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
G Vps13b vacuolar protein sorting 13 homolog B decreases expression EXP Irinotecan results in decreased expression of VPS13B mRNA CTD PMID:20097248 NCBI chr 7:74,118,834...74,722,341 JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A decreases expression ISO Irinotecan analog results in decreased expression of VPS4A mRNA CTD PMID:18927307 NCBI chr19:39,230,050...39,243,298
Ensembl chr19:39,229,754...39,243,496
JBrowse link
G Vti1a vesicle transport through interaction with t-SNAREs 1A decreases expression ISO Irinotecan analog results in decreased expression of VTI1A mRNA CTD PMID:18927307 NCBI chr 1:276,310,072...276,508,635
Ensembl chr 1:276,309,927...276,490,602
JBrowse link
G Wapl WAPL cohesin release factor decreases expression ISO Irinotecan analog results in decreased expression of WAPL mRNA CTD PMID:18927307 NCBI chr16:11,029,325...11,108,867
Ensembl chr16:11,032,531...11,106,589
JBrowse link
G Wasl WASP like actin nucleation promoting factor decreases expression ISO Irinotecan analog results in decreased expression of WASL mRNA CTD PMID:18927307 NCBI chr 4:51,677,722...51,726,212
Ensembl chr 4:51,677,722...51,726,212
JBrowse link
G Wdfy1 WD repeat and FYVE domain containing 1 affects expression EXP Irinotecan affects the expression of WDFY1 mRNA CTD PMID:20097248 NCBI chr 9:85,477,070...85,528,885
Ensembl chr 9:85,475,841...85,528,869
JBrowse link
G Wnt16 Wnt family member 16 increases expression ISO Irinotecan analog results in increased expression of WNT16 mRNA CTD PMID:18927307 NCBI chr 4:49,369,246...49,388,156
Ensembl chr 4:49,369,296...49,379,703
JBrowse link
G Wsb1 WD repeat and SOCS box-containing 1 increases expression ISO Irinotecan analog results in increased expression of WSB1 mRNA CTD PMID:18927307 NCBI chr10:66,586,905...66,602,984
Ensembl chr10:66,586,924...66,602,987
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [Irinotecan co-treated with alvocidib] results in increased cleavage of XIAP protein CTD PMID:11751522 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor decreases expression ISO Irinotecan results in decreased expression of XPA protein CTD PMID:11593056 NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
JBrowse link
G Xpo7 exportin 7 decreases expression ISO Irinotecan analog results in decreased expression of XPO7 mRNA CTD PMID:18927307 NCBI chr15:52,357,845...52,443,055
Ensembl chr15:52,357,853...52,443,055
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases expression ISO Irinotecan metabolite results in decreased expression of XRCC4 mRNA; Irinotecan results in decreased expression of XRCC4 mRNA CTD PMID:15956246 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression ISO Irinotecan analog results in decreased expression of XRCC5 mRNA CTD PMID:18927307 NCBI chr 9:79,659,275...79,748,050
Ensembl chr 9:79,659,251...79,748,078
JBrowse link
G Yaf2 YY1 associated factor 2 decreases expression ISO Irinotecan analog results in decreased expression of YAF2 mRNA CTD PMID:18927307 NCBI chr 7:134,505,352...134,560,713
Ensembl chr 7:134,505,737...134,560,713
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase decreases expression ISO Irinotecan metabolite results in decreased expression of YES1 mRNA; Irinotecan results in decreased expression of YES1 mRNA CTD PMID:15956246 NCBI chr 9:121,802,471...121,918,906
Ensembl chr 9:121,802,673...121,902,678
JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 decreases expression ISO Irinotecan analog results in decreased expression of ZBTB20 mRNA CTD PMID:18927307 NCBI chr11:62,014,925...62,561,113
Ensembl chr11:62,014,925...62,451,184
JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 decreases expression ISO Irinotecan analog results in decreased expression of ZC3HAV1 mRNA CTD PMID:18927307 NCBI chr 4:66,012,111...66,062,160
Ensembl chr 4:66,011,915...66,062,089
JBrowse link
G Zcchc12 zinc finger CCHC-type containing 12 increases expression ISO Irinotecan analog results in increased expression of ZCCHC12 mRNA CTD PMID:18927307 NCBI chr  X:122,808,581...122,811,790
Ensembl chr  X:122,808,605...122,811,789
JBrowse link
G Zdhhc21 zinc finger DHHC-type palmitoyltransferase 21 decreases expression ISO Irinotecan analog results in decreased expression of ZDHHC21 mRNA CTD PMID:18927307 NCBI chr 5:100,924,621...100,983,412
Ensembl chr 5:100,924,622...100,977,902
JBrowse link
G Zfp161 zinc finger protein 161 decreases expression ISO Irinotecan analog results in decreased expression of ZBTB14 mRNA CTD PMID:18927307 NCBI chr 9:117,739,067...117,744,273
Ensembl chr 9:117,737,611...117,744,300
JBrowse link
G Zfp207 zinc finger protein 207 decreases expression ISO Irinotecan analog results in decreased expression of ZNF207 mRNA CTD PMID:18927307 NCBI chr10:67,762,970...67,784,854
Ensembl chr10:67,762,995...67,774,787
JBrowse link
G Zfp36l2 zinc finger protein 36, C3H type-like 2 decreases expression ISO Irinotecan metabolite results in decreased expression of ZFP36L2 mRNA; Irinotecan results in decreased expression of ZFP36L2 mRNA CTD PMID:15956246 NCBI chr 6:7,417,416...7,423,447
Ensembl chr 6:7,417,425...7,421,456
JBrowse link
G Zfp574 zinc finger protein 574 decreases expression ISO Irinotecan analog results in decreased expression of ZNF574 mRNA CTD PMID:18927307 NCBI chr 1:81,952,067...81,957,330
Ensembl chr 1:81,952,067...81,957,329
JBrowse link
G Zfp637 zinc finger protein 637 multiple interactions ISO ZNF32 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 4:149,857,127...149,882,828
Ensembl chr 4:149,877,889...149,882,824
JBrowse link
G Zfp668 zinc finger protein 668 decreases expression ISO Irinotecan analog results in decreased expression of ZNF668 mRNA CTD PMID:18927307 NCBI chr 1:199,310,935...199,321,231
Ensembl chr 1:199,310,935...199,320,727
JBrowse link
G Zfx zinc finger protein X-linked decreases expression ISO Irinotecan metabolite results in decreased expression of ZFX mRNA; Irinotecan results in decreased expression of ZFX mRNA CTD PMID:15956246 NCBI chr  X:63,158,368...63,204,971
Ensembl chr  X:63,158,976...63,204,530
JBrowse link
G Znf408 zinc finger protein 408 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of ZNF408 mRNA CTD PMID:16391804 NCBI chr 3:80,549,102...80,555,186 JBrowse link
G Znrf1 zinc and ring finger 1 decreases expression ISO Irinotecan analog results in decreased expression of ZNRF1 mRNA CTD PMID:18927307 NCBI chr19:43,750,205...43,834,962
Ensembl chr19:43,750,278...43,832,878
JBrowse link
G Zrsr2 zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 multiple interactions ISO ZRSR2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr  X:32,304,707...32,327,419
Ensembl chr  X:32,304,757...32,328,364
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pro-agent 8830
          prodrug 8610
            irinotecan 682
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672