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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:irinotecan
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Accession:CHEBI:80630 term browser browse the term
Definition:A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
Synonyms:exact_synonym: (4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate
 related_synonym: Formula=C33H38N4O6;   HSDB 7607;   InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1;   InChIKey=UWKQSNNFCGGAFS-XIFFEERXSA-N;   Irinophore C;   Irinotecan lactone;   Irinotecan mylan;   SMILES=C1(=CC=C2C(=C1)C(=C3C(=N2)C=4N(C3)C(C5=C(C4)[C@](C(OC5)=O)(CC)O)=O)CC)OC(=O)N6CCC(CC6)N7CCCCC7;   irinotecanum
 xref: CAS:97682-44-5;   DrugBank:DB00762;   Drug_Central:1482;   HMDB:HMDB0014900;   KEGG:C16641;   KEGG:D08086;   LINCS:LSM-2167
 xref_mesh: MESH:D000077146
 xref: PDBeChem:CP0;   PMID:26081596;   PMID:26352218;   PMID:26381420;   PMID:26487578;   PMID:26503200;   PMID:26526067;   PMID:26541586;   PMID:26574999;   PMID:26580826;   PMID:26739304;   Reaxys:4839096;   Wikipedia:Irinotecan
 cyclic_relationship: is_conjugate_base_of CHEBI:90895


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irinotecan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP Irinotecan results in increased expression of A2M mRNA CTD PMID:20097248 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases response to substance
affects metabolic processing
affects export
affects response to substance
affects expression
ISO
EXP
ABCB1 exon SNP affects the susceptibility to and affects the metabolism of Irinotecan
ABCB1A gene mutant form results in decreased susceptibility to Irinotecan
ABCB1A protein affects the metabolism of Irinotecan
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCB1A protein affects the metabolism of Irinotecan]; Everolimus inhibits the reaction [ABCB1A protein affects the metabolism of Irinotecan]
ABCB1 protein affects the export of Irinotecan
ABCB1 gene polymorphism affects the susceptibility to Irinotecan
Irinotecan affects the expression of ABCB1A mRNA
ABCB1 protein results in decreased susceptibility to Irinotecan
CTD PMID:12960109 PMID:15655543 PMID:15801936 PMID:16815871 PMID:20097248 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects metabolic processing
multiple interactions
ISO ABCB1B protein affects the metabolism of Irinotecan
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCB1B protein affects the metabolism of Irinotecan]; Everolimus inhibits the reaction [ABCB1B protein affects the metabolism of Irinotecan]
CTD PMID:24727322 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance
decreases expression
multiple interactions
ISO ABCC1 protein results in decreased susceptibility to Irinotecan
Irinotecan analog results in decreased expression of ABCC1 mRNA
[selenomethylselenocysteine co-treated with Irinotecan] results in decreased expression of ABCC1
CTD PMID:15897249 PMID:16815871 PMID:18927307 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects response to substance
decreases response to substance
ISO ABCC2 gene polymorphism affects the susceptibility to Irinotecan; ABCC2 gene polymorphism affects the susceptibility to Irinotecan metabolite
ABCC2 gene mutant form results in decreased susceptibility to Irinotecan
ABCC2 protein results in decreased susceptibility to Irinotecan
CTD PMID:16815871 PMID:18981587 PMID:32387182 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects export ISO ABCC4 protein affects the export of Irinotecan CTD PMID:15827327 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases response to substance
affects metabolic processing
increases transport
affects response to substance
decreases response to substance
affects export
ISO bis(4-nitrophenyl)phosphate inhibits the reaction [ABCG2 protein affects the metabolism of Irinotecan]; Everolimus inhibits the reaction [ABCG2 protein affects the metabolism of Irinotecan]
ABCG2 gene mutant form results in increased susceptibility to Irinotecan
ABCG2 protein results in increased transport of Irinotecan
ABCG2 mRNA results in increased susceptibility to Irinotecan; ABCG2 protein results in increased susceptibility to Irinotecan
ABCG2 affects the susceptibility to Irinotecan
ABCG2 gene polymorphism affects the susceptibility to and affects the metabolism of Irinotecan; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of Irinotecan]
ABCG2 protein results in decreased susceptibility to Irinotecan; ABCG2 results in decreased susceptibility to Irinotecan
ABCG2 protein affects the export of Irinotecan
CTD PMID:10606239 PMID:12869632 PMID:15239142 PMID:15655543 PMID:15695404 More... NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Abhd13 abhydrolase domain containing 13 decreases expression ISO Irinotecan analog results in decreased expression of ABHD13 mRNA CTD PMID:18927307 NCBI chr16:79,501,879...79,516,712
Ensembl chr16:79,501,727...79,516,748
JBrowse link
G Abi2 abl-interactor 2 decreases expression ISO Irinotecan results in decreased expression of ABI2 mRNA CTD PMID:20185912 NCBI chr 9:61,856,379...61,904,029
Ensembl chr 9:61,827,139...61,905,699
JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO Irinotecan analog results in decreased expression of ACACA mRNA CTD PMID:18927307 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 increases response to substance ISO ACAT1 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Ache acetylcholinesterase decreases activity EXP Irinotecan results in decreased activity of ACHE protein CTD PMID:11740913 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
ISO Irinotecan results in increased expression of ACTA2 protein
Silymarin affects the reaction [Irinotecan results in increased expression of ACTA2 protein]
CTD PMID:28454924 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ada adenosine deaminase affects expression EXP Irinotecan affects the expression of ADA mRNA CTD PMID:20097248 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Adam19 ADAM metallopeptidase domain 19 increases expression ISO Irinotecan analog results in increased expression of ADAM19 mRNA CTD PMID:18927307 NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression EXP Irinotecan results in increased expression of ADAMTS1 mRNA CTD PMID:20097248 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Add3 adducin 3 decreases expression ISO Irinotecan metabolite results in decreased expression of ADD3 mRNA; Irinotecan results in decreased expression of ADD3 mRNA CTD PMID:15956246 NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) affects expression EXP Irinotecan affects the expression of ADH1 mRNA CTD PMID:20097248 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Adi1 acireductone dioxygenase 1 decreases expression ISO Irinotecan analog results in decreased expression of ADI1 mRNA CTD PMID:18927307 NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842
JBrowse link
G Adk adenosine kinase affects expression EXP Irinotecan affects the expression of ADK mRNA CTD PMID:20097248 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
JBrowse link
G Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 affects expression EXP Irinotecan affects the expression of AGPAT4 mRNA CTD PMID:20097248 NCBI chr 1:48,525,131...48,633,798
Ensembl chr 1:48,527,323...48,633,345
JBrowse link
G Agt angiotensinogen decreases expression ISO Irinotecan analog results in decreased expression of AGT mRNA CTD PMID:18927307 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ahcyl1 adenosylhomocysteinase-like 1 affects expression EXP Irinotecan affects the expression of AHCYL1 mRNA CTD PMID:20097248 NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815
JBrowse link
G Ak2 adenylate kinase 2 increases response to substance ISO AK2 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632
JBrowse link
G Akap10 A-kinase anchoring protein 10 decreases expression ISO Irinotecan metabolite results in decreased expression of AKAP10 mRNA; Irinotecan results in decreased expression of AKAP10 mRNA CTD PMID:15956246 NCBI chr10:46,545,464...46,608,768
Ensembl chr10:46,551,532...46,608,769
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression ISO Irinotecan metabolite results in increased expression of ALAS2 mRNA; Irinotecan results in increased expression of ALAS2 mRNA CTD PMID:15956246 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519
JBrowse link
G Alb albumin decreases expression ISO Irinotecan analog results in decreased expression of ALB mRNA CTD PMID:18927307 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 decreases expression EXP Irinotecan results in decreased expression of ALDH18A1 mRNA CTD PMID:30012503 NCBI chr 1:239,375,657...239,407,967
Ensembl chr 1:239,375,669...239,407,890
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Irinotecan metabolite results in decreased expression of ALDH1A1 mRNA; Irinotecan results in decreased expression of ALDH1A1 mRNA CTD PMID:15956246 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 increases expression ISO Irinotecan analog results in increased expression of AMIGO2 mRNA CTD PMID:18927307 NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695
JBrowse link
G Amy1a amylase, alpha 1A affects expression EXP Irinotecan affects the expression of AMY1A mRNA CTD PMID:20097248 NCBI chr 2:201,382,678...201,397,487
Ensembl chr 2:201,382,675...201,397,816
JBrowse link
G Angptl2 angiopoietin-like 2 multiple interactions ISO ANGPTL2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178
JBrowse link
G Ankh ANKH inorganic pyrophosphate transport regulator affects expression EXP Irinotecan affects the expression of ANKH mRNA CTD PMID:20097248 NCBI chr 2:78,153,027...78,280,181
Ensembl chr 2:78,153,026...78,280,187
JBrowse link
G Ankrd17 ankyrin repeat domain 17 decreases expression ISO Irinotecan analog results in decreased expression of ANKRD17 mRNA CTD PMID:18927307 NCBI chr14:17,723,239...17,862,625
Ensembl chr14:17,721,932...17,862,617
JBrowse link
G Ankrd28 ankyrin repeat domain 28 decreases expression ISO Irinotecan analog results in decreased expression of ANKRD28 mRNA CTD PMID:18927307 NCBI chr16:6,918,487...7,050,244
Ensembl chr16:6,914,336...7,050,249
JBrowse link
G Anxa13 annexin A13 decreases expression ISO Irinotecan analog results in decreased expression of ANXA13 mRNA CTD PMID:18927307 NCBI chr 7:89,884,356...89,936,907
Ensembl chr 7:89,884,356...89,936,907
JBrowse link
G Anxa2 annexin A2 increases expression
multiple interactions
ISO Irinotecan results in increased expression of ANXA2 mRNA
[PHY 906 co-treated with Irinotecan] affects the expression of ANXA2 mRNA
CTD PMID:15152939 PMID:32812032 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Anxa6 annexin A6 increases expression ISO Irinotecan metabolite results in increased expression of ANXA6 mRNA; Irinotecan results in increased expression of ANXA6 mRNA CTD PMID:15956246 NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433
JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 decreases expression ISO Irinotecan analog results in decreased expression of AP2B1 mRNA CTD PMID:18927307 NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013
JBrowse link
G Ap2s1 adaptor related protein complex 2 subunit sigma 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of AP2S1 mRNA CTD PMID:16391804 NCBI chr 1:77,417,496...77,428,903
Ensembl chr 1:77,417,477...77,428,905
JBrowse link
G Apc APC regulator of WNT signaling pathway decreases expression ISO Irinotecan metabolite results in decreased expression of APC mRNA; Irinotecan results in decreased expression of APC mRNA CTD PMID:15956246 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase increases expression ISO Irinotecan metabolite results in increased expression of ARAF mRNA; Irinotecan results in increased expression of ARAF mRNA CTD PMID:15956246 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073
JBrowse link
G Areg amphiregulin multiple interactions
increases expression
ISO Gefitinib inhibits the reaction [Irinotecan metabolite results in increased expression of AREG mRNA]; Gefitinib inhibits the reaction [Irinotecan results in increased expression of AREG mRNA]
Irinotecan metabolite results in increased expression of AREG mRNA; Irinotecan results in increased expression of AREG mRNA
CTD PMID:15723263 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Arf1 ADP-ribosylation factor 1 multiple interactions
decreases expression
ISO ARF1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
Irinotecan analog results in decreased expression of ARF1 mRNA
CTD PMID:18927307 NCBI chr10:43,997,983...44,014,543
Ensembl chr10:43,997,986...44,014,434
JBrowse link
G Arg2 arginase 2 affects expression EXP Irinotecan affects the expression of ARG2 mRNA CTD PMID:20097248 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G Arhgap5 Rho GTPase activating protein 5 decreases expression
increases expression
ISO Irinotecan metabolite results in decreased expression of ARHGAP5 mRNA; Irinotecan results in decreased expression of ARHGAP5 mRNA
Irinotecan metabolite results in increased expression of ARHGAP5 mRNA; Irinotecan results in increased expression of ARHGAP5 mRNA
CTD PMID:15956246 NCBI chr 6:69,975,904...70,039,299
Ensembl chr 6:69,976,214...70,037,660
JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 decreases expression ISO Irinotecan analog results in decreased expression of ARHGEF12 mRNA CTD PMID:18927307 NCBI chr 8:43,350,070...43,475,404
Ensembl chr 8:43,353,799...43,476,366
JBrowse link
G Arhgef39 Rho guanine nucleotide exchange factor 39 decreases expression ISO Irinotecan analog results in decreased expression of ARHGEF39 mRNA CTD PMID:18927307 NCBI chr 5:57,752,509...57,756,079
Ensembl chr 5:57,752,509...57,756,109
JBrowse link
G Arid2 AT-rich interaction domain 2 decreases expression ISO Irinotecan analog results in decreased expression of ARID2 mRNA CTD PMID:18927307 NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512
JBrowse link
G Arid4a AT-rich interaction domain 4A decreases expression ISO Irinotecan metabolite results in decreased expression of ARID4A mRNA; Irinotecan results in decreased expression of ARID4A mRNA CTD PMID:15956246 NCBI chr 6:89,522,463...89,593,868
Ensembl chr 6:89,522,442...89,593,510
JBrowse link
G Arl4c ADP ribosylation factor like GTPase 4C increases expression ISO Irinotecan analog results in increased expression of ARL4C mRNA CTD PMID:18927307 NCBI chr 9:89,300,335...89,303,770
Ensembl chr 9:89,298,005...89,304,513
JBrowse link
G Armc8 armadillo repeat containing 8 decreases expression ISO Irinotecan analog results in decreased expression of ARMC8 mRNA CTD PMID:18927307 NCBI chr 8:100,036,946...100,131,544
Ensembl chr 8:100,036,946...100,131,520
JBrowse link
G Arsb arylsulfatase B decreases expression ISO Irinotecan analog results in decreased expression of ARSB mRNA CTD PMID:18927307 NCBI chr 2:25,002,210...25,162,675
Ensembl chr 2:25,002,346...25,162,671
JBrowse link
G As3mt arsenite methyltransferase affects expression EXP Irinotecan affects the expression of AS3MT mRNA CTD PMID:20097248 NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872
JBrowse link
G Asb2 ankyrin repeat and SOCS box-containing 2 affects expression EXP Irinotecan affects the expression of ASB2 mRNA CTD PMID:20097248 NCBI chr 6:122,474,754...122,511,014
Ensembl chr 6:122,474,756...122,510,854
JBrowse link
G Ass1 argininosuccinate synthase 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of ASS1 mRNA CTD PMID:16391804 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Irinotecan metabolite results in increased expression of ATF3 mRNA; Irinotecan results in increased expression of ATF3 mRNA CTD PMID:15956246 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atg10 autophagy related 10 decreases expression ISO Irinotecan metabolite results in decreased expression of ATG10 mRNA; Irinotecan results in decreased expression of ATG10 mRNA CTD PMID:15956246 NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233
JBrowse link
G Atl2 atlastin GTPase 2 increases expression ISO Irinotecan analog results in increased expression of ATL2 mRNA CTD PMID:18927307 NCBI chr 6:15,139,071...15,180,421
Ensembl chr 6:15,139,044...15,180,421
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO Irinotecan results in increased phosphorylation of ATM protein CTD PMID:22898888 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 affects expression EXP Irinotecan affects the expression of ATP2B1 mRNA CTD PMID:20097248 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 decreases response to substance ISO ATP2B4 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP multiple interactions ISO ATP5PO mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
JBrowse link
G Atp6v0b ATPase H+ transporting V0 subunit B increases response to substance ISO ATP6V0B protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 5:131,423,384...131,424,900
Ensembl chr 5:131,423,387...131,426,401
JBrowse link
G Atp7a ATPase copper transporting alpha decreases response to substance
increases export
ISO ATP7A protein results in decreased susceptibility to Irinotecan
ATP7A protein results in increased export of Irinotecan
CTD PMID:17510416 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 affects expression EXP Irinotecan affects the expression of ATP8B1 mRNA CTD PMID:20097248 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
JBrowse link
G Atrx ATRX, chromatin remodeler decreases expression ISO Irinotecan analog results in decreased expression of ATRX mRNA CTD PMID:18927307 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Irinotecan metabolite results in decreased expression of AURKB mRNA; Irinotecan results in decreased expression of AURKB mRNA CTD PMID:15956246 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G B2m beta-2 microglobulin increases expression EXP Irinotecan results in increased expression of B2M mRNA CTD PMID:20097248 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor increases expression ISO Irinotecan analog results in increased expression of BAMBI mRNA CTD PMID:18927307 NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased expression of BAX protein CTD PMID:15754201 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects response to substance
ISO [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in decreased expression of BCL2 protein; [Fluorouracil co-treated with Irinotecan] results in decreased expression of BCL2 mRNA; [Fluorouracil co-treated with Irinotecan] results in decreased expression of BCL2 protein
BCL2 protein affects the susceptibility to Irinotecan
CTD PMID:15754201 PMID:16391804 PMID:18949393 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO Irinotecan results in decreased expression of BCL2L1 mRNA
Irinotecan promotes the reaction [AS602868 results in decreased expression of BCL2L1 mRNA]
CTD PMID:16432164 PMID:18182997 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl7a BAF chromatin remodeling complex subunit BCL7A increases expression ISO Irinotecan metabolite results in increased expression of BCL7A mRNA; Irinotecan results in increased expression of BCL7A mRNA CTD PMID:15956246 NCBI chr12:33,211,978...33,243,886
Ensembl chr12:33,223,931...33,243,886
JBrowse link
G Bcl9 BCL9, transcription coactivator increases expression ISO Irinotecan metabolite results in increased expression of BCL9 mRNA; Irinotecan results in increased expression of BCL9 mRNA CTD PMID:15956246 NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435
JBrowse link
G Bcr BCR activator of RhoGEF and GTPase decreases expression ISO Irinotecan analog results in decreased expression of BCR mRNA CTD PMID:18927307 NCBI chr20:13,471,679...13,596,497
Ensembl chr20:13,471,668...13,597,016
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression
ISO [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased cleavage of BID protein
Irinotecan results in decreased expression of BID protein
CTD PMID:15754201 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 affects expression EXP Irinotecan affects the expression of BIRC3 mRNA CTD PMID:20097248 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
ISO Irinotecan metabolite results in decreased expression of BIRC5 mRNA; Irinotecan results in decreased expression of BIRC5 mRNA
[Irinotecan co-treated with Bortezomib] results in decreased expression of BIRC5 protein; Irinotecan promotes the reaction [AS602868 results in decreased expression of BIRC5 mRNA]
CTD PMID:15956246 PMID:16373703 PMID:18182997 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmp8a bone morphogenetic protein 8a increases expression ISO Irinotecan metabolite results in increased expression of BMP8A mRNA; Irinotecan results in increased expression of BMP8A mRNA CTD PMID:15956246 NCBI chr 5:135,589,839...135,617,785
Ensembl chr 5:135,591,716...135,617,785
JBrowse link
G Bod1l1 biorientation of chromosomes in cell division 1-like 1 decreases expression ISO Irinotecan analog results in decreased expression of BOD1L1 mRNA CTD PMID:18927307 NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490
JBrowse link
G Boll boule homolog, RNA binding protein multiple interactions ISO BOLL mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 9:56,734,890...56,859,917
Ensembl chr 9:56,733,584...56,859,916
JBrowse link
G Btbd3 BTB domain containing 3 decreases expression ISO Irinotecan analog results in decreased expression of BTBD3 mRNA CTD PMID:18927307 NCBI chr 3:125,591,427...125,621,660
Ensembl chr 3:125,591,490...125,619,038
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression
affects expression
ISO
EXP
Irinotecan metabolite results in decreased expression of BUB1 mRNA; Irinotecan results in decreased expression of BUB1 mRNA
Irinotecan affects the expression of BUB1 mRNA
CTD PMID:15956246 PMID:20097248 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G C1qc complement C1q C chain multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of C1QC mRNA CTD PMID:32812032 NCBI chr 5:149,127,424...149,130,732
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G C2 complement C2 affects expression EXP Irinotecan affects the expression of C2 mRNA CTD PMID:20097248 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G C3ar1 complement C3a receptor 1 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of C3AR1 mRNA CTD PMID:32812032 NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
JBrowse link
G C7 complement C7 increases expression EXP Irinotecan results in increased expression of C7 mRNA CTD PMID:20097248 NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535
JBrowse link
G Cabin1 calcineurin binding protein 1 decreases expression ISO Irinotecan analog results in decreased expression of CABIN1 mRNA CTD PMID:18927307 NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I decreases expression ISO Irinotecan analog results in decreased expression of CACNA1I mRNA CTD PMID:18927307 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
JBrowse link
G Casp1 caspase 1 increases cleavage
multiple interactions
affects expression
ISO
EXP
Irinotecan results in increased cleavage of CASP1 protein
[Irinotecan co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein; EVP 4593 inhibits the reaction [Irinotecan results in increased cleavage of CASP1 protein]; pyrazolanthrone inhibits the reaction [Irinotecan results in increased cleavage of CASP1 protein]
Irinotecan affects the expression of CASP1 mRNA
CTD PMID:20097248 PMID:26431797 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO [Irinotecan co-treated with alvocidib] results in increased activity of CASP3 protein; [Irinotecan co-treated with rucaparib] results in increased expression of CASP3 protein; Irinotecan promotes the reaction [AS602868 results in increased cleavage of and results in increased activity of CASP3 protein]; RNF34 protein inhibits the reaction [Irinotecan results in increased activity of CASP3 protein]; Ursodeoxycholic Acid promotes the reaction [Irinotecan results in increased activity of CASP3 protein]
Irinotecan results in increased expression of CASP3 protein
CTD PMID:11751522 PMID:16080519 PMID:16432164 PMID:18182997 PMID:22898888 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 decreases expression ISO Irinotecan metabolite results in decreased expression of CASP4 mRNA; Irinotecan results in decreased expression of CASP4 mRNA CTD PMID:15956246 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO Irinotecan promotes the reaction [AS602868 results in increased cleavage of and results in increased activity of CASP8 protein]; Irinotecan results in increased cleavage of and results in increased activity of CASP8 protein; Ursodeoxycholic Acid promotes the reaction [Irinotecan results in increased activity of CASP8 protein] CTD PMID:16432164 PMID:18182997 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Irinotecan results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Irinotecan results in increased activity of CASP9 protein]; Irinotecan promotes the reaction [AS602868 results in increased cleavage of and results in increased activity of CASP9 protein]; Irinotecan results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:18182997 PMID:22898888 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cblc Cbl proto-oncogene C affects expression EXP Irinotecan affects the expression of CBLC mRNA CTD PMID:20097248 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755
JBrowse link
G Cck cholecystokinin affects expression EXP Irinotecan affects the expression of CCK mRNA CTD PMID:20097248 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccn1 cellular communication network factor 1 decreases response to substance ISO CCN1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Irinotecan results in increased expression of CCN2 mRNA CTD PMID:20185912 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Irinotecan metabolite results in decreased expression of CCNA2 mRNA; Irinotecan results in decreased expression of CCNA2 mRNA CTD PMID:15956246 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression EXP Irinotecan results in decreased expression of CCNB1 mRNA CTD PMID:20097248 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb1ip1 cyclin B1 interacting protein 1 increases response to substance ISO CCNB1IP1 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr15:24,014,905...24,031,357
Ensembl chr15:24,014,908...24,028,475
JBrowse link
G Ccnb2 cyclin B2 increases response to substance
decreases expression
ISO
EXP
CCNB2 protein results in increased susceptibility to Irinotecan
Irinotecan results in decreased expression of CCNB2 mRNA
Irinotecan metabolite results in decreased expression of CCNB2 mRNA; Irinotecan results in decreased expression of CCNB2 mRNA
CTD PMID:15956246 PMID:16734730 PMID:20097248 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccnf cyclin F decreases expression ISO Irinotecan metabolite results in decreased expression of CCNF mRNA; Irinotecan results in decreased expression of CCNF mRNA CTD PMID:15956246 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Irinotecan analog results in increased expression of CCNG2 mRNA CTD PMID:18927307 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 increases expression ISO Irinotecan metabolite results in increased expression of CCR1 mRNA; Irinotecan results in increased expression of CCR1 mRNA CTD PMID:15956246 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO Irinotecan metabolite results in decreased expression of CCR6 mRNA; Irinotecan results in decreased expression of CCR6 mRNA CTD PMID:15956246 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A decreases expression ISO Irinotecan analog results in decreased expression of CCT6A mRNA CTD PMID:18927307 NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337
JBrowse link
G Cd163 CD163 molecule increases expression EXP Irinotecan results in increased expression of CD163 mRNA CTD PMID:20097248 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
JBrowse link
G Cd36 CD36 molecule affects expression EXP Irinotecan affects the expression of CD36 mRNA CTD PMID:20097248 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd47 Cd47 molecule increases expression ISO Irinotecan analog results in increased expression of CD47 mRNA CTD PMID:18927307 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
JBrowse link
G Cd70 Cd70 molecule increases expression ISO Irinotecan metabolite results in increased expression of CD70 mRNA; Irinotecan results in increased expression of CD70 mRNA CTD PMID:15956246 NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715
JBrowse link
G Cd80 Cd80 molecule increases expression ISO Irinotecan metabolite results in increased expression of CD80 mRNA; Irinotecan results in increased expression of CD80 mRNA CTD PMID:15956246 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cdc20 cell division cycle 20 affects expression
increases response to substance
EXP
ISO
Irinotecan affects the expression of CDC20 mRNA
CDC20 protein results in increased susceptibility to Irinotecan
CTD PMID:16734730 PMID:20097248 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc25b cell division cycle 25B decreases expression ISO Irinotecan metabolite results in decreased expression of CDC25B mRNA; Irinotecan results in decreased expression of CDC25B mRNA CTD PMID:15956246 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
JBrowse link
G Cdc42bpa CDC42 binding protein kinase alpha decreases expression ISO Irinotecan analog results in decreased expression of CDC42BPA mRNA CTD PMID:18927307 NCBI chr13:91,683,775...91,903,732
Ensembl chr13:91,684,007...91,903,732
JBrowse link
G Cdca3 cell division cycle associated 3 decreases expression EXP Irinotecan results in decreased expression of CDCA3 mRNA CTD PMID:20097248 NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799
JBrowse link
G Cdh4 cadherin 4 decreases expression ISO Irinotecan analog results in decreased expression of CDH4 mRNA CTD PMID:18927307 NCBI chr 3:166,525,098...167,003,380
Ensembl chr 3:166,525,099...167,003,371
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression EXP
ISO
Irinotecan results in decreased expression of CDK1 mRNA
Irinotecan metabolite results in decreased expression of CDK1 mRNA; Irinotecan results in decreased expression of CDK1 mRNA
CTD PMID:15956246 PMID:20097248 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk13 cyclin-dependent kinase 13 decreases expression ISO Irinotecan metabolite results in decreased expression of CDK13 mRNA; Irinotecan results in decreased expression of CDK13 mRNA CTD PMID:15956246 NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721
JBrowse link
G Cdk5r2 cyclin-dependent kinase 5 regulatory subunit 2 increases expression ISO Irinotecan metabolite results in increased expression of CDK5R2 mRNA; Irinotecan results in increased expression of CDK5R2 mRNA CTD PMID:15956246 NCBI chr 9:76,416,251...76,417,719
Ensembl chr 9:76,416,062...76,418,344
JBrowse link
G Cdk6 cyclin-dependent kinase 6 affects expression ISO Irinotecan analog affects the expression of CDK6 mRNA CTD PMID:18927307 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
affects expression
ISO Irinotecan results in increased expression of CDKN1A mRNA; Irinotecan results in increased expression of CDKN1A protein
[Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased expression of CDKN1A protein
Irinotecan affects the expression of CDKN1A protein
CTD PMID:15132777 PMID:15754201 PMID:22510560 PMID:22898888 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects expression
increases response to substance
decreases expression
ISO Irinotecan affects the expression of CDKN2A protein
CDKN2A results in increased susceptibility to Irinotecan
Irinotecan results in decreased expression of CDKN2A mRNA
CTD PMID:16432164 PMID:22898888 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO
EXP
Irinotecan metabolite results in decreased expression of CDKN3 mRNA; Irinotecan results in decreased expression of CDKN3 mRNA CTD PMID:15956246 PMID:20097248 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Cdon cell adhesion associated, oncogene regulated decreases expression ISO Irinotecan analog results in decreased expression of CDON mRNA CTD PMID:18927307 NCBI chr 8:33,775,123...33,861,635
Ensembl chr 8:33,806,183...33,859,033
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP Irinotecan results in increased expression of CEBPD mRNA CTD PMID:20097248 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Cel carboxyl ester lipase increases response to substance ISO CEL protein results in increased susceptibility to Irinotecan CTD PMID:9766666 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035
JBrowse link
G Cela3b chymotrypsin like elastase 3B affects expression EXP Irinotecan affects the expression of CELA3B mRNA CTD PMID:20097248 NCBI chr 5:149,628,773...149,636,937
Ensembl chr 5:149,628,773...149,636,937
JBrowse link
G Cenpe centromere protein E decreases expression ISO Irinotecan analog results in decreased expression of CENPE mRNA; Irinotecan metabolite results in decreased expression of CENPE mRNA; Irinotecan results in decreased expression of CENPE mRNA CTD PMID:15956246 PMID:18927307 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Cenpf centromere protein F decreases expression ISO Irinotecan metabolite results in decreased expression of CENPF mRNA; Irinotecan results in decreased expression of CENPF mRNA CTD PMID:15956246 NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
JBrowse link
G Cep192 centrosomal protein 192 decreases expression ISO Irinotecan analog results in decreased expression of CEP192 mRNA CTD PMID:18927307 NCBI chr18:61,346,957...61,458,405
Ensembl chr18:61,332,158...61,458,379
JBrowse link
G Cep290 centrosomal protein 290 decreases expression ISO Irinotecan analog results in decreased expression of CEP290 mRNA CTD PMID:18927307 NCBI chr 7:35,310,071...35,399,392
Ensembl chr 7:35,310,199...35,399,392
JBrowse link
G Cep295 centrosomal protein 295 decreases expression ISO Irinotecan analog results in decreased expression of CEP295 mRNA CTD PMID:18927307 NCBI chr 8:12,156,568...12,194,542
Ensembl chr 8:12,156,554...12,194,552
JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis
increases response to substance
ISO CES1 protein results in increased hydrolysis of Irinotecan
CES1 mRNA results in increased susceptibility to Irinotecan
CTD PMID:15100172 PMID:15239142 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Ces2h carboxylesterase 2H increases expression
multiple interactions
increases response to substance
increases chemical synthesis
increases metabolic processing
affects response to substance
increases hydrolysis
ISO Irinotecan results in increased expression of CES2 mRNA
CES2 mRNA results in increased chemical synthesis of and results in increased abundance of Irinotecan; CES2 mRNA results in increased metabolism of and results in increased activity of Irinotecan; CES2 protein affects the metabolism of and results in increased activity of Irinotecan; CES2 protein results in increased hydrolysis of and results in increased activity of Irinotecan; CES2 protein results in increased metabolism of and results in increased activity of Irinotecan
CES2 protein results in increased susceptibility to Irinotecan
CES2 protein results in increased chemical synthesis of Irinotecan
CES2 protein results in increased metabolism of Irinotecan
CES2 protein affects the susceptibility to Irinotecan
CES2 protein results in increased hydrolysis of Irinotecan
CTD PMID:10728672 PMID:11716702 PMID:12171891 PMID:12171903 PMID:14581373 More... NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Ces3a carboxylesterase 3a increases hydrolysis ISO CES3 protein results in increased hydrolysis of Irinotecan CTD PMID:15100172 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression
affects response to substance
multiple interactions
ISO Irinotecan results in decreased expression of CFLAR protein
CFLAR protein affects the susceptibility to Irinotecan
CFLAR protein alternative form inhibits the reaction [Irinotecan results in increased activity of TNFSF10 protein]
CTD PMID:16373718 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Cftr CF transmembrane conductance regulator affects expression EXP Irinotecan affects the expression of CFTR mRNA CTD PMID:20097248 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Chd1 chromodomain helicase DNA binding protein 1 decreases expression ISO Irinotecan metabolite results in decreased expression of CHD1 mRNA; Irinotecan results in decreased expression of CHD1 mRNA CTD PMID:15956246 NCBI chr 1:56,661,743...56,729,119
Ensembl chr 1:56,664,054...56,728,125
JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation
multiple interactions
ISO Irinotecan results in increased phosphorylation of CHEK1 protein
Irinotecan results in increased phosphorylation of and results in increased activity of CHEK1 protein; SAR 020106 inhibits the reaction [Irinotecan results in increased phosphorylation of CHEK1 protein]
CTD PMID:22111927 PMID:22510560 PMID:22898888 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO Irinotecan results in increased phosphorylation of CHEK2 protein CTD PMID:22898888 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression EXP Irinotecan results in decreased expression of CKS2 mRNA CTD PMID:20097248 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Cldn2 claudin 2 affects expression EXP Irinotecan affects the expression of CLDN2 mRNA CTD PMID:20097248 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838
JBrowse link
G Clec10a C-type lectin domain containing 10A increases expression EXP Irinotecan results in increased expression of CLEC10A mRNA CTD PMID:20097248 NCBI chr10:54,876,244...54,880,439
Ensembl chr10:54,876,260...54,880,435
JBrowse link
G Clgn calmegin increases expression ISO Irinotecan analog results in increased expression of CLGN mRNA CTD PMID:18927307 NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758
JBrowse link
G Clps colipase affects expression EXP Irinotecan affects the expression of CLPS mRNA CTD PMID:20097248 NCBI chr20:6,620,529...6,622,709
Ensembl chr20:6,620,529...6,622,689
JBrowse link
G Cltc clathrin heavy chain decreases expression
multiple interactions
ISO Irinotecan analog results in decreased expression of CLTC mRNA
CLTC protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:18927307 NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737
JBrowse link
G Cnnm2 cyclin and CBS domain divalent metal cation transport mediator 2 increases expression ISO Irinotecan analog results in increased expression of CNNM2 mRNA CTD PMID:18927307 NCBI chr 1:245,643,682...245,769,542
Ensembl chr 1:245,643,768...245,763,286
JBrowse link
G Col13a1 collagen type XIII alpha 1 chain increases expression ISO Irinotecan analog results in increased expression of COL13A1 mRNA CTD PMID:18927307 NCBI chr20:29,783,965...29,924,116
Ensembl chr20:29,783,965...29,924,032
JBrowse link
G Col4a4 collagen type IV alpha 4 chain decreases expression ISO Irinotecan analog results in decreased expression of COL4A4 mRNA CTD PMID:18927307 NCBI chr 9:83,833,173...83,875,436
Ensembl chr 9:83,755,515...83,875,876
JBrowse link
G Col6a1 collagen type VI alpha 1 chain increases expression ISO Irinotecan metabolite results in increased expression of COL6A1 mRNA; Irinotecan results in increased expression of COL6A1 mRNA CTD PMID:15956246 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Col7a1 collagen type VII alpha 1 chain decreases response to substance ISO COL7A1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 8:109,604,877...109,637,252
Ensembl chr 8:109,604,861...109,637,252
JBrowse link
G Commd6 COMM domain containing 6 increases expression ISO Irinotecan metabolite results in increased expression of COMMD6 mRNA; Irinotecan results in increased expression of COMMD6 mRNA CTD PMID:15956246 NCBI chr15:78,467,333...78,474,382
Ensembl chr15:78,467,804...78,474,382
JBrowse link
G Copa COPI coat complex subunit alpha increases expression ISO Irinotecan analog results in increased expression of COPA mRNA CTD PMID:18927307 NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874
JBrowse link
G Coq9 coenzyme Q9 decreases expression ISO Irinotecan results in decreased expression of COQ9 mRNA CTD PMID:20185912 NCBI chr19:10,166,948...10,179,976
Ensembl chr19:10,166,951...10,179,949
JBrowse link
G Cpe carboxypeptidase E increases expression ISO Irinotecan analog results in increased expression of CPE mRNA CTD PMID:18927307 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
JBrowse link
G Crebbp CREB binding protein decreases expression ISO Irinotecan analog results in decreased expression of CREBBP mRNA; Irinotecan metabolite results in decreased expression of CREBBP mRNA; Irinotecan results in decreased expression of CREBBP mRNA CTD PMID:15956246 PMID:18927307 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 decreases expression ISO Irinotecan analog results in decreased expression of CRIM1 mRNA CTD PMID:18927307 NCBI chr 6:16,695,864...16,870,264
Ensembl chr 6:16,697,829...16,870,259
JBrowse link
G Ctbp2 C-terminal binding protein 2 decreases expression
multiple interactions
ISO Irinotecan analog results in decreased expression of CTBP2 mRNA
[Fluorouracil co-treated with Irinotecan] results in decreased expression of CTBP2 mRNA; CTBP2 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:16391804 PMID:18927307 NCBI chr 1:187,782,064...187,918,115
Ensembl chr 1:187,782,682...187,920,222
JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO Irinotecan analog results in increased expression of CTH mRNA CTD PMID:18927307 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Cul4a cullin 4A decreases expression ISO Irinotecan analog results in decreased expression of CUL4A mRNA CTD PMID:18927307 NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 affects expression EXP Irinotecan affects the expression of CXCL11 mRNA CTD PMID:20097248 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Irinotecan analog results in decreased expression of CXCL12 mRNA CTD PMID:18927307 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions
ISO Irinotecan results in increased expression of CXCL1 protein
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [Irinotecan results in increased expression of CXCL1 protein]]; carvacrol inhibits the reaction [Irinotecan results in increased expression of CXCL1 protein]
CTD PMID:27838229 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 affects expression EXP Irinotecan affects the expression of CYP27A1 mRNA CTD PMID:20097248 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity ISO Irinotecan metabolite results in decreased activity of CYP2C9 protein CTD PMID:11901092 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
affects metabolic processing
increases response to substance
increases oxidation
ISO Irinotecan metabolite results in decreased activity of CYP3A4 protein; Irinotecan results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Irinotecan
CYP3A4 mRNA results in increased susceptibility to Irinotecan
CYP3A4 protein results in increased oxidation of Irinotecan
CTD PMID:11901092 PMID:15100172 PMID:15239142 PMID:15523087 PMID:15655543 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO [selenomethylselenocysteine co-treated with Irinotecan] results in increased expression of CYP3A5 CTD PMID:15897249 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 affects expression EXP Irinotecan affects the expression of CYP4B1 mRNA CTD PMID:20097248 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 affects expression EXP Irinotecan affects the expression of CYP4F1 mRNA CTD PMID:20097248 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
JBrowse link
G Daglb diacylglycerol lipase, beta decreases expression ISO Irinotecan analog results in decreased expression of DAGLB mRNA CTD PMID:18927307 NCBI chr12:11,059,732...11,102,170
Ensembl chr12:11,059,732...11,102,154
JBrowse link
G Dbf4 DBF4 zinc finger increases response to substance ISO DBF4 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066
JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 decreases expression ISO Irinotecan analog results in decreased expression of DCAF8 mRNA CTD PMID:18927307 NCBI chr13:84,609,838...84,667,025
Ensembl chr13:84,610,248...84,669,726
JBrowse link
G Dclre1a DNA cross-link repair 1A decreases expression ISO Irinotecan metabolite results in decreased expression of DCLRE1A mRNA; Irinotecan results in decreased expression of DCLRE1A mRNA CTD PMID:15956246 NCBI chr 1:255,569,911...255,589,815
Ensembl chr 1:255,569,919...255,589,678
JBrowse link
G Dctn2 dynactin subunit 2 increases expression ISO Irinotecan analog results in increased expression of DCTN2 mRNA CTD PMID:18927307 NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543
JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression ISO Irinotecan metabolite results in increased expression of DDB2 mRNA; Irinotecan results in increased expression of DDB2 mRNA CTD PMID:15956246 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
JBrowse link
G Ddhd1 DDHD domain containing 1 decreases expression ISO Irinotecan analog results in decreased expression of DDHD1 mRNA CTD PMID:18927307 NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Irinotecan results in increased expression of DDIT3 mRNA CTD PMID:20097248 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression EXP Irinotecan results in increased expression of DDIT4 mRNA CTD PMID:20097248 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Ddx17 DEAD-box helicase 17 decreases expression ISO Irinotecan results in decreased expression of DDX17 mRNA CTD PMID:20185912 NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked affects expression EXP Irinotecan affects the expression of DDX3X mRNA CTD PMID:20097248 NCBI chr  X:9,479,532...9,493,455
Ensembl chr  X:9,479,532...9,493,168
JBrowse link
G Ddx5 DEAD-box helicase 5 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of DDX5 mRNA CTD PMID:32812032 NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283
JBrowse link
G Dedd death effector domain-containing decreases expression ISO Irinotecan analog results in decreased expression of DEDD mRNA CTD PMID:18927307 NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332
JBrowse link
G Dennd4a DENN domain containing 4A decreases expression ISO Irinotecan metabolite results in decreased expression of DENND4A mRNA; Irinotecan results in decreased expression of DENND4A mRNA CTD PMID:15956246 NCBI chr 8:65,322,920...65,436,331
Ensembl chr 8:65,322,941...65,436,330
JBrowse link
G Denr density regulated reinitiation and release factor decreases expression ISO Irinotecan analog results in decreased expression of DENR mRNA CTD PMID:18927307 NCBI chr12:32,662,512...32,685,283
Ensembl chr12:32,662,516...32,683,843
JBrowse link
G Depdc1b DEP domain containing 1B decreases expression ISO Irinotecan analog results in decreased expression of DEPDC1B mRNA CTD PMID:18927307 NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779
JBrowse link
G Desi2 desumoylating isopeptidase 2 decreases expression ISO Irinotecan analog results in decreased expression of DESI2 mRNA CTD PMID:18927307 NCBI chr13:89,961,767...90,011,255
Ensembl chr13:89,961,934...90,016,416
JBrowse link
G Dffb DNA fragmentation factor subunit beta increases response to substance ISO DFFB protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit decreases expression ISO Irinotecan analog results in decreased expression of DGCR8 mRNA CTD PMID:18927307 NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242
JBrowse link
G Dip2a disco-interacting protein 2 homolog A decreases expression ISO Irinotecan analog results in decreased expression of DIP2A mRNA CTD PMID:18927307 NCBI chr20:12,284,566...12,371,068
Ensembl chr20:12,284,654...12,370,217
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein decreases expression ISO Irinotecan analog results in decreased expression of DLC1 mRNA CTD PMID:18927307 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439
JBrowse link
G Dld dihydrolipoamide dehydrogenase affects expression EXP Irinotecan affects the expression of DLD mRNA CTD PMID:20097248 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 decreases expression
multiple interactions
ISO Irinotecan analog results in decreased expression of DLG1 mRNA
DLG1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:18927307 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
JBrowse link
G Dlx4 distal-less homeobox 4 increases expression ISO Irinotecan analog results in increased expression of DLX4 mRNA CTD PMID:18927307 NCBI chr10:80,085,037...80,090,434
Ensembl chr10:80,085,465...80,090,456
JBrowse link
G Dmac2l distal membrane arm assembly component 2 like decreases expression ISO Irinotecan analog results in decreased expression of DMAC2L mRNA CTD PMID:18927307 NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933
JBrowse link
G Dmwd DM1 locus, WD repeat containing increases expression ISO Irinotecan metabolite results in increased expression of DMWD mRNA; Irinotecan results in increased expression of DMWD mRNA CTD PMID:15956246 NCBI chr 1:78,722,436...78,729,224
Ensembl chr 1:78,722,330...78,740,593
JBrowse link
G Dok6 docking protein 6 decreases expression ISO Irinotecan results in decreased expression of DOK6 mRNA CTD PMID:20185912 NCBI chr18:82,572,762...83,015,951
Ensembl chr18:82,572,762...83,015,951
JBrowse link
G Dph2 diphthamide biosynthesis 2 decreases expression ISO Irinotecan analog results in decreased expression of DPH2 mRNA CTD PMID:18927307 NCBI chr 5:131,428,434...131,431,394
Ensembl chr 5:131,428,268...131,431,395
JBrowse link
G Dph6 diphthamine biosynthesis 6 decreases expression ISO Irinotecan analog results in decreased expression of DPH6 mRNA CTD PMID:18927307 NCBI chr 3:101,307,229...101,437,463
Ensembl chr 3:101,307,231...101,534,603
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases response to substance
decreases expression
ISO DPYD protein results in decreased susceptibility to Irinotecan
Irinotecan metabolite results in decreased expression of DPYD mRNA; Irinotecan results in decreased expression of DPYD mRNA
CTD PMID:15956246 PMID:16734730 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982
JBrowse link
G Drd5 dopamine receptor D5 multiple interactions ISO DRD5 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr14:72,489,347...72,490,774
Ensembl chr14:72,489,347...72,490,774
JBrowse link
G Drg1 developmentally regulated GTP binding protein 1 multiple interactions ISO [selenomethylselenocysteine co-treated with Irinotecan] results in decreased expression of DRG1 CTD PMID:15897249 NCBI chr14:78,103,876...78,119,976
Ensembl chr14:78,103,876...78,119,953
JBrowse link
G Dst dystonin decreases expression ISO Irinotecan analog results in decreased expression of DST mRNA CTD PMID:18927307 NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615
JBrowse link
G Duox2 dual oxidase 2 affects expression EXP Irinotecan affects the expression of DUOX2 mRNA CTD PMID:20097248 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression EXP Irinotecan results in increased expression of DUSP1 mRNA CTD PMID:20097248 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp2 dual specificity phosphatase 2 increases expression ISO Irinotecan metabolite results in increased expression of DUSP2 mRNA; Irinotecan results in increased expression of DUSP2 mRNA CTD PMID:15956246 NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499
JBrowse link
G Dusp6 dual specificity phosphatase 6 affects expression EXP Irinotecan affects the expression of DUSP6 mRNA CTD PMID:20097248 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases expression ISO Irinotecan metabolite results in decreased expression of DYRK1A mRNA; Irinotecan results in decreased expression of DYRK1A mRNA CTD PMID:15956246 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 decreases expression
affects expression
ISO
EXP
Irinotecan metabolite results in decreased expression of DYRK2 mRNA; Irinotecan results in decreased expression of DYRK2 mRNA
Irinotecan affects the expression of DYRK2 mRNA
CTD PMID:15956246 PMID:20097248 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Irinotecan metabolite results in increased phosphorylation of EGFR protein]; bisindolylmaleimide I inhibits the reaction [Irinotecan results in increased phosphorylation of EGFR protein]; Gefitinib inhibits the reaction [Irinotecan metabolite results in increased phosphorylation of and results in increased activity of EGFR protein]; Gefitinib inhibits the reaction [Irinotecan results in increased phosphorylation of and results in increased activity of EGFR protein]; Go 6976 inhibits the reaction [Irinotecan metabolite results in increased phosphorylation of EGFR protein]; Go 6976 inhibits the reaction [Irinotecan results in increased phosphorylation of EGFR protein]; Irinotecan metabolite results in increased phosphorylation of and results in increased activity of EGFR protein; Irinotecan results in increased phosphorylation of and results in increased activity of EGFR protein; rottlerin inhibits the reaction [Irinotecan metabolite results in increased phosphorylation of EGFR protein]; rottlerin inhibits the reaction [Irinotecan results in increased phosphorylation of EGFR protein] CTD PMID:15723263 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 increases expression ISO
EXP
Irinotecan metabolite results in increased expression of EGR1 mRNA; Irinotecan results in increased expression of EGR1 mRNA CTD PMID:15956246 PMID:16280599 PMID:20097248 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 affects expression ISO Irinotecan analog affects the expression of EIF2AK4 mRNA CTD PMID:18927307 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of EIF4E mRNA CTD PMID:32812032 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eml2 EMAP like 2 multiple interactions ISO EML2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 1:78,827,595...78,859,343
Ensembl chr 1:78,828,080...78,859,341
JBrowse link
G Eml4 EMAP like 4 affects expression EXP Irinotecan affects the expression of EML4 mRNA CTD PMID:20097248 NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879
JBrowse link
G Eno1 enolase 1 decreases expression ISO Irinotecan analog results in decreased expression of ENO1 mRNA CTD PMID:18927307 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Ep300 E1A binding protein p300 decreases expression ISO Irinotecan metabolite results in decreased expression of EP300 mRNA; Irinotecan results in decreased expression of EP300 mRNA CTD PMID:15956246 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Eppk1 epiplakin 1 increases expression ISO Irinotecan analog results in increased expression of EPPK1 mRNA CTD PMID:18927307 NCBI chr 7:107,816,919...107,842,946 JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects expression EXP Irinotecan affects the expression of ERBB2 mRNA CTD PMID:20097248 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 increases expression ISO Irinotecan metabolite results in increased expression of ERBB4 mRNA; Irinotecan results in increased expression of ERBB4 mRNA CTD PMID:15956246 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 decreases expression ISO Irinotecan analog results in decreased expression of ERC1 mRNA CTD PMID:18927307 NCBI chr 4:152,763,664...153,055,706
Ensembl chr 4:152,767,419...153,055,639
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit decreases expression ISO Irinotecan results in decreased expression of ERCC1 protein CTD PMID:11593056 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Ereg epiregulin decreases expression ISO Irinotecan analog results in decreased expression of EREG mRNA CTD PMID:18927307 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor increases expression ISO Irinotecan metabolite results in increased expression of ETS2 mRNA; Irinotecan results in increased expression of ETS2 mRNA CTD PMID:15956246 NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
JBrowse link
G Etv6 ETS variant transcription factor 6 decreases expression ISO Irinotecan metabolite results in decreased expression of ETV6 mRNA; Irinotecan results in decreased expression of ETV6 mRNA CTD PMID:15956246 NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992
JBrowse link
G Exoc4 exocyst complex component 4 decreases expression ISO Irinotecan analog results in decreased expression of EXOC4 mRNA CTD PMID:18927307 NCBI chr 4:61,807,706...62,584,316
Ensembl chr 4:61,807,761...62,585,723
JBrowse link
G F8 coagulation factor VIII multiple interactions ISO F8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857
JBrowse link
G Fabp1 fatty acid binding protein 1 affects expression EXP Irinotecan affects the expression of FABP1 mRNA CTD PMID:20097248 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fabp6 fatty acid binding protein 6 increases expression ISO Irinotecan analog results in increased expression of FABP6 mRNA CTD PMID:18927307 NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282
JBrowse link
G Fam219a family with sequence similarity 219, member A decreases expression ISO Irinotecan analog results in decreased expression of FAM219A mRNA CTD PMID:18927307 NCBI chr 5:56,679,272...56,729,959
Ensembl chr 5:56,680,613...56,729,924
JBrowse link
G Fam3c FAM3 metabolism regulating signaling molecule C decreases expression ISO Irinotecan analog results in decreased expression of FAM3C mRNA CTD PMID:18927307 NCBI chr 4:50,839,929...50,887,276
Ensembl chr 4:50,838,818...50,888,078
JBrowse link
G Fancg FA complementation group G increases expression ISO Irinotecan metabolite results in increased expression of FANCG mRNA; Irinotecan results in increased expression of FANCG mRNA CTD PMID:15956246 NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029
JBrowse link
G Farsb phenylalanyl-tRNA synthetase subunit beta decreases expression ISO Irinotecan analog results in decreased expression of FARSB mRNA CTD PMID:18927307 NCBI chr 9:79,887,852...79,947,082
Ensembl chr 9:79,887,842...79,947,045
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO Irinotecan results in increased expression of and results in increased localization of FAS protein; STAT1 protein promotes the reaction [Irinotecan results in increased localization of FAS protein]
Irinotecan results in increased expression of FAS mRNA
CTD PMID:16204068 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO [selenomethylselenocysteine co-treated with Irinotecan] results in increased expression of FASLG
Irinotecan results in increased expression of FASL protein
CTD PMID:15897249 PMID:21475811 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fbxw5 F-box and WD repeat domain containing 5 increases expression ISO Irinotecan results in increased expression of FBXW5 mRNA CTD PMID:20185912 NCBI chr 3:8,322,543...8,327,092
Ensembl chr 3:8,322,543...8,327,092
JBrowse link
G Fcf1 FCF1 rRNA-processing protein affects expression ISO Irinotecan analog affects the expression of FCF1 mRNA CTD PMID:18927307 NCBI chr 6:104,617,780...104,629,643
Ensembl chr 6:104,617,770...104,629,643
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb increases expression EXP Irinotecan results in increased expression of FCGR2B mRNA CTD PMID:20097248 NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Irinotecan metabolite results in increased expression of FGF2 mRNA; Irinotecan results in increased expression of FGF2 mRNA CTD PMID:15956246 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgf9 fibroblast growth factor 9 decreases expression ISO Irinotecan analog results in decreased expression of FGF9 mRNA CTD PMID:18927307 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
JBrowse link
G Fgl2 fibrinogen-like 2 increases expression EXP Irinotecan results in increased expression of FGL2 mRNA CTD PMID:20097248 NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207
JBrowse link
G Fh fumarate hydratase affects expression EXP Irinotecan affects the expression of FH mRNA CTD PMID:20097248 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression EXP Irinotecan results in increased expression of FKBP5 mRNA CTD PMID:20097248 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 affects expression EXP Irinotecan affects the expression of FMO5 mRNA CTD PMID:20097248 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Irinotecan analog results in increased expression of FN1 mRNA; Irinotecan metabolite results in increased expression of FN1 mRNA; Irinotecan results in increased expression of FN1 mRNA CTD PMID:15956246 PMID:18927307 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression
ISO Irinotecan metabolite results in increased expression of FOS mRNA; Irinotecan results in increased expression of FOS mRNA
Irinotecan results in decreased expression of FOS mRNA
CTD PMID:15956246 PMID:16432164 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Irinotecan metabolite results in increased expression of FOSB mRNA; Irinotecan results in increased expression of FOSB mRNA CTD PMID:15956246 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Foxa1 forkhead box A1 affects expression EXP Irinotecan affects the expression of FOXA1 mRNA CTD PMID:20097248 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
JBrowse link
G Frk fyn-related Src family tyrosine kinase affects expression EXP Irinotecan affects the expression of FRK mRNA CTD PMID:20097248 NCBI chr20:38,265,416...38,371,038
Ensembl chr20:38,265,280...38,371,114
JBrowse link
G Frmd5 FERM domain containing 5 decreases expression ISO Irinotecan analog results in decreased expression of FRMD5 mRNA CTD PMID:18927307 NCBI chr 3:108,492,099...108,763,715
Ensembl chr 3:108,474,562...108,763,498
JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase decreases expression ISO Irinotecan analog results in decreased expression of FTO mRNA CTD PMID:18927307 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083
JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 increases expression ISO Irinotecan results in increased expression of FXYD3 mRNA CTD PMID:15152939 NCBI chr 1:86,305,531...86,312,455 JBrowse link
G Fyb1 FYN binding protein 1 decreases expression ISO Irinotecan analog results in decreased expression of FYB1 mRNA CTD PMID:18927307 NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629
JBrowse link
G G0s2 G0/G1switch 2 increases expression EXP Irinotecan results in increased expression of G0S2 mRNA CTD PMID:20097248 NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
JBrowse link
G G2e3 G2/M-phase specific E3 ubiquitin protein ligase decreases expression ISO Irinotecan analog results in decreased expression of G2E3 mRNA CTD PMID:18927307 NCBI chr 6:68,763,847...68,795,305
Ensembl chr 6:68,764,185...68,793,924
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Irinotecan results in increased expression of GADD45A mRNA CTD PMID:20097248 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression EXP Irinotecan results in increased expression of GADD45G mRNA CTD PMID:20097248 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Gamt guanidinoacetate N-methyltransferase affects expression EXP Irinotecan affects the expression of GAMT mRNA CTD PMID:20097248 NCBI chr 7:9,448,590...9,451,778
Ensembl chr 7:9,448,628...9,451,778
JBrowse link
G Gata3 GATA binding protein 3 decreases expression ISO Irinotecan metabolite results in decreased expression of GATA3 mRNA; Irinotecan results in decreased expression of GATA3 mRNA CTD PMID:15956246 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Gata4 GATA binding protein 4 affects expression EXP Irinotecan affects the expression of GATA4 mRNA CTD PMID:20097248 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Gcg glucagon affects expression EXP Irinotecan affects the expression of GCG mRNA CTD PMID:20097248 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Irinotecan metabolite results in increased expression of GDF15 mRNA; Irinotecan results in increased expression of GDF15 mRNA CTD PMID:15956246 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression EXP Irinotecan results in increased expression of GEM mRNA CTD PMID:20097248 NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 decreases expression ISO Irinotecan analog results in decreased expression of GGT1 mRNA CTD PMID:18927307 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gja1 gap junction protein, alpha 1 affects expression
increases expression
ISO
EXP
Irinotecan analog affects the expression of GJA1 mRNA
Irinotecan results in increased expression of GJA1 mRNA
CTD PMID:18927307 PMID:20097248 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gk glycerol kinase decreases expression ISO Irinotecan analog results in decreased expression of GK mRNA CTD PMID:18927307 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631
JBrowse link
G Gkn1 gastrokine 1 affects expression EXP Irinotecan affects the expression of GKN1 mRNA CTD PMID:20097248 NCBI chr 4:119,790,101...119,795,389
Ensembl chr 4:119,790,101...119,795,389
JBrowse link
G Glrx3 glutaredoxin 3 affects expression ISO Irinotecan analog affects the expression of GLRX3 mRNA CTD PMID:18927307 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
JBrowse link
G Gna13 G protein subunit alpha 13 increases expression ISO Irinotecan analog results in increased expression of GNA13 mRNA CTD PMID:18927307 NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774
JBrowse link
G Gng11 G protein subunit gamma 11 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of GNG11 mRNA CTD PMID:32812032 NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442
JBrowse link
G Gpatch2l G patch domain containing 2-like decreases expression ISO Irinotecan analog results in decreased expression of GPATCH2L mRNA CTD PMID:18927307 NCBI chr 6:105,883,383...105,935,644
Ensembl chr 6:105,883,460...105,934,888
JBrowse link
G Gpatch4 G patch domain containing 4 decreases expression ISO Irinotecan analog results in decreased expression of GPATCH4 mRNA CTD PMID:18927307 NCBI chr 2:173,499,700...173,520,346
Ensembl chr 2:173,509,897...173,518,684
JBrowse link
G Gphn gephyrin decreases expression EXP Irinotecan results in decreased expression of GPHN mRNA CTD PMID:20097248 NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612
JBrowse link
G Gpr183 G protein-coupled receptor 183 increases expression ISO Irinotecan metabolite results in increased expression of GPR183 mRNA; Irinotecan results in increased expression of GPR183 mRNA CTD PMID:15956246 NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO Irinotecan metabolite results in increased expression of GPX3 mRNA; Irinotecan results in increased expression of GPX3 mRNA CTD PMID:15956246 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist increases expression EXP Irinotecan results in increased expression of GREM1 mRNA CTD PMID:20097248 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 affects expression EXP Irinotecan affects the expression of GSTA3 mRNA CTD PMID:20097248 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 affects expression EXP Irinotecan affects the expression of GSTA4 mRNA CTD PMID:20097248 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gzmb granzyme B affects expression EXP Irinotecan affects the expression of GZMB mRNA CTD PMID:20097248 NCBI chr15:30,343,361...30,346,792 JBrowse link
G H2ax H2A.X variant histone increases expression ISO Irinotecan metabolite results in increased expression of H2AX mRNA; Irinotecan results in increased expression of H2AX mRNA CTD PMID:15956246 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G H4c3 H4 clustered histone 3 decreases expression ISO Irinotecan analog results in decreased expression of H4C3 mRNA CTD PMID:18927307
G Hbegf heparin-binding EGF-like growth factor increases expression
multiple interactions
ISO Irinotecan metabolite results in increased expression of HBEGF mRNA; Irinotecan results in increased expression of HBEGF mRNA
Gefitinib inhibits the reaction [Irinotecan metabolite results in increased expression of HBEGF mRNA]; Gefitinib inhibits the reaction [Irinotecan results in increased expression of HBEGF mRNA]
CTD PMID:15723263 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hbg1 hemoglobin subunit gamma 1 decreases expression ISO Irinotecan analog results in decreased expression of HBG1 mRNA CTD PMID:18927307 NCBI chr 1:158,271,993...158,273,371
Ensembl chr 1:158,271,873...158,273,425
JBrowse link
G Hcfc1 host cell factor C1 decreases expression ISO Irinotecan analog results in decreased expression of HCFC1 mRNA CTD PMID:18927307 NCBI chr  X:151,687,779...151,712,688
Ensembl chr  X:151,687,779...151,712,638
JBrowse link
G Hectd2 HECT domain E3 ubiquitin protein ligase 2 decreases expression ISO Irinotecan analog results in decreased expression of HECTD2 mRNA CTD PMID:18927307 NCBI chr 1:234,274,967...234,345,598
Ensembl chr 1:234,275,705...234,343,487
JBrowse link
G Hells helicase, lymphoid specific decreases expression ISO Irinotecan analog results in decreased expression of HELLS mRNA CTD PMID:18927307 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases activity ISO Irinotecan results in increased activity of HES1 protein CTD PMID:19147571 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Hgfac HGF activator affects expression EXP Irinotecan affects the expression of HGFAC mRNA CTD PMID:20097248 NCBI chr14:75,707,588...75,714,182
Ensembl chr14:75,707,591...75,714,278
JBrowse link
G Hk2 hexokinase 2 affects expression EXP Irinotecan affects the expression of HK2 mRNA CTD PMID:20097248 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO Irinotecan metabolite results in decreased expression of HMMR mRNA; Irinotecan results in decreased expression of HMMR mRNA CTD PMID:15956246 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
JBrowse link
G Hmx1 H6 family homeobox 1 increases expression ISO Irinotecan results in increased expression of HMX1 mRNA CTD PMID:20185912 NCBI chr14:75,361,207...75,364,993
Ensembl chr14:75,361,225...75,364,993
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 decreases expression ISO Irinotecan analog results in decreased expression of HNRNPA1 mRNA CTD PMID:18927307 NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of HNRNPA3 mRNA CTD PMID:32812032 NCBI chr 3:60,578,574...60,588,755
Ensembl chr 3:60,578,673...60,588,306
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D decreases expression ISO Irinotecan analog results in decreased expression of HNRNPD mRNA CTD PMID:18927307 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Irinotecan analog results in decreased expression of HNRNPDL mRNA CTD PMID:18927307 NCBI chr14:9,558,079...9,563,654
Ensembl chr14:9,557,425...9,562,506
JBrowse link
G Hrg histidine-rich glycoprotein increases expression ISO Irinotecan metabolite results in increased expression of HRG mRNA; Irinotecan results in increased expression of HRG mRNA CTD PMID:15956246 NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389
JBrowse link
G Hs3st3b1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 increases expression ISO Irinotecan analog results in increased expression of HS3ST3B1 mRNA CTD PMID:18927307 NCBI chr10:48,561,473...48,593,970
Ensembl chr10:48,561,473...48,593,970
JBrowse link
G Hspa4l heat shock protein family A (Hsp70) member 4 like decreases expression ISO Irinotecan metabolite results in decreased expression of HSPA4L mRNA; Irinotecan results in decreased expression of HSPA4L mRNA CTD PMID:15956246 NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of HTATIP2 mRNA CTD PMID:16391804 NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
JBrowse link
G Hypk Huntingtin interacting protein K affects expression ISO Irinotecan analog affects the expression of HYPK mRNA CTD PMID:18927307 NCBI chr 3:108,434,997...108,436,370
Ensembl chr 3:108,432,539...108,436,370
JBrowse link
G Ibtk inhibitor of Bruton tyrosine kinase decreases expression ISO Irinotecan results in decreased expression of IBTK mRNA CTD PMID:20185912 NCBI chr 8:86,625,591...86,698,661
Ensembl chr 8:86,625,597...86,698,260
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Irinotecan metabolite results in decreased expression of ID2 mRNA; Irinotecan results in decreased expression of ID2 mRNA CTD PMID:15956246 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Ier3 immediate early response 3 increases expression ISO Irinotecan results in increased expression of IER3 mRNA CTD PMID:20185912 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Ifi27l2b interferon, alpha-inducible protein 27 like 2B multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of IFI27L2 mRNA CTD PMID:16391804 NCBI chr 6:122,598,872...122,600,358
Ensembl chr 6:122,598,872...122,600,360
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 increases expression EXP Irinotecan results in increased expression of IFITM1 mRNA CTD PMID:20097248 NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 increases expression EXP Irinotecan results in increased expression of IFITM3 mRNA CTD PMID:20097248 NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
EXP Ciprofloxacin inhibits the reaction [Irinotecan promotes the reaction [Mitogens results in increased expression of IFNG protein]]; Irinotecan inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]; Irinotecan inhibits the reaction [Mitogens results in increased expression of IFNG protein]; Irinotecan promotes the reaction [Mitogens results in increased expression of IFNG protein]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of IFNG protein]; Thalidomide promotes the reaction [Irinotecan results in increased expression of IFNG protein] CTD PMID:16815871 PMID:19401694 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO Irinotecan metabolite results in increased expression of IGF1 mRNA; Irinotecan results in increased expression of IGF1 mRNA CTD PMID:15956246 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 increases expression EXP Irinotecan results in increased expression of IGFBP5 mRNA CTD PMID:20097248 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Ighg1 immunoglobulin heavy constant gamma 1 decreases expression ISO Irinotecan analog results in decreased expression of IGHG1 mRNA CTD PMID:18927307 Ensembl chr 6:132,389,370...132,393,397 JBrowse link
G Il10 interleukin 10 multiple interactions
decreases secretion
ISO
EXP
Deoxycholic Acid promotes the reaction [Irinotecan results in decreased secretion of IL10 protein]; Taurodeoxycholic Acid promotes the reaction [Irinotecan results in decreased secretion of IL10 protein]
Ciprofloxacin inhibits the reaction [Irinotecan inhibits the reaction [Mitogens results in increased expression of IL10 protein]]; Irinotecan inhibits the reaction [Mitogens results in increased expression of IL10 protein]
CTD PMID:19401694 PMID:26706406 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 affects expression EXP Irinotecan affects the expression of IL13RA1 mRNA CTD PMID:20097248 NCBI chr  X:115,348,860...115,408,682
Ensembl chr  X:115,348,860...115,408,681
JBrowse link
G Il15 interleukin 15 affects expression EXP Irinotecan affects the expression of IL15 mRNA CTD PMID:20097248 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il17a interleukin 17A increases expression ISO Irinotecan results in increased expression of IL17A mRNA; Irinotecan results in increased expression of IL17A protein CTD PMID:26431797 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 increases expression
multiple interactions
ISO Irinotecan results in increased expression of IL18 mRNA; Irinotecan results in increased expression of IL18 protein
[Fluorouracil co-treated with Irinotecan] results in decreased expression of IL18 mRNA; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL18 protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA; EVP 4593 inhibits the reaction [[Lipopolysaccharides co-treated with Irinotecan] results in increased expression of and results in increased secretion of IL18 protein]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with Irinotecan] results in increased expression of and results in increased secretion of IL18 protein]
[Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL18 protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA; EVP 4593 inhibits the reaction [Irinotecan results in increased expression of and results in increased secretion of IL18 protein]; pyrazolanthrone inhibits the reaction [Irinotecan results in increased expression of and results in increased secretion of IL18 protein]
CTD PMID:16391804 PMID:26431797 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects expression
increases expression
ISO
EXP
[Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL1B protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; EVP 4593 inhibits the reaction [[Lipopolysaccharides co-treated with Irinotecan] results in increased expression of and results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with Irinotecan] results in increased expression of and results in increased secretion of IL1B protein]
Irinotecan affects the expression of IL1B protein
Irinotecan metabolite results in increased expression of IL1B mRNA; Irinotecan results in increased expression of IL1B mRNA
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [Irinotecan results in increased expression of IL1B protein]]; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL1B protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; carvacrol inhibits the reaction [Irinotecan results in increased expression of IL1B protein]; Irinotecan results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein; Silymarin inhibits the reaction [Irinotecan results in increased expression of IL1B protein]
Irinotecan results in increased expression of IL1B mRNA; Irinotecan results in increased expression of IL1B protein
Ciprofloxacin inhibits the reaction [Irinotecan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Irinotecan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of IL1B protein]; Thalidomide promotes the reaction [Irinotecan results in increased expression of IL1B protein]
CTD PMID:15956246 PMID:16815871 PMID:18535404 PMID:19401694 PMID:26431797 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions
EXP Irinotecan results in decreased expression of IL2 protein
Ciprofloxacin inhibits the reaction [Irinotecan promotes the reaction [Mitogens results in increased expression of IL2 protein]]; Irinotecan inhibits the reaction [Mitogens results in increased expression of IL2 protein]; Irinotecan promotes the reaction [Mitogens results in increased expression of IL2 protein]; Thalidomide inhibits the reaction [Irinotecan results in decreased expression of IL2 protein]; Thalidomide promotes the reaction [Irinotecan results in decreased expression of IL2 protein]
CTD PMID:16815871 PMID:19401694 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
decreases response to substance
ISO
EXP
Irinotecan results in increased expression of IL6 mRNA; Irinotecan results in increased expression of IL6 protein
Silymarin inhibits the reaction [Irinotecan results in increased expression of IL6 protein]
IL6 protein results in decreased susceptibility to Irinotecan
Ciprofloxacin inhibits the reaction [Irinotecan inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Ciprofloxacin inhibits the reaction [Irinotecan promotes the reaction [Mitogens results in increased expression of IL6 protein]]; Irinotecan inhibits the reaction [Mitogens results in increased expression of IL6 protein]; Irinotecan promotes the reaction [Mitogens results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of IL6 protein]
CTD PMID:16815871 PMID:17537833 PMID:18535404 PMID:19401694 PMID:26431797 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Immp2l inner mitochondrial membrane peptidase subunit 2 decreases expression ISO Irinotecan analog results in decreased expression of IMMP2L mRNA CTD PMID:18927307 NCBI chr 6:58,070,035...58,970,165 JBrowse link
G Immt inner membrane mitochondrial protein affects expression ISO Irinotecan analog affects the expression of IMMT mRNA CTD PMID:18927307 NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109
JBrowse link
G Ing3 inhibitor of growth family, member 3 decreases expression ISO Irinotecan analog results in decreased expression of ING3 mRNA CTD PMID:18927307 NCBI chr 4:50,477,954...50,505,168
Ensembl chr 4:50,477,962...50,503,715
JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO Irinotecan analog results in decreased expression of INSIG1 mRNA CTD PMID:18927307 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Itga2 integrin subunit alpha 2 increases expression ISO Irinotecan analog results in increased expression of ITGA2 mRNA CTD PMID:18927307 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itgae integrin subunit alpha E increases response to substance ISO ITGAE protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr10:57,704,813...57,764,093
Ensembl chr10:57,591,753...57,764,093
JBrowse link
G Itgav integrin subunit alpha V decreases expression ISO Irinotecan metabolite results in decreased expression of ITGAV mRNA; Irinotecan results in decreased expression of ITGAV mRNA CTD PMID:15956246 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itgax integrin subunit alpha X increases expression ISO Irinotecan metabolite results in increased expression of ITGAX mRNA; Irinotecan results in increased expression of ITGAX mRNA CTD PMID:15956246 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
JBrowse link
G Itgb3bp integrin subunit beta 3 binding protein decreases expression ISO Irinotecan metabolite results in decreased expression of ITGB3BP mRNA; Irinotecan results in decreased expression of ITGB3BP mRNA CTD PMID:15956246 NCBI chr 5:114,460,217...114,525,538
Ensembl chr 5:114,460,221...114,525,704
JBrowse link
G Jchain joining chain of multimeric IgA and IgM affects expression EXP Irinotecan affects the expression of JCHAIN mRNA CTD PMID:20097248 NCBI chr14:19,538,560...19,546,384
Ensembl chr14:19,538,952...19,546,298
JBrowse link
G Jpt1 Jupiter microtubule associated homolog 1 decreases expression ISO Irinotecan analog results in decreased expression of JPT1 mRNA CTD PMID:18927307 NCBI chr10:100,744,468...100,762,504
Ensembl chr10:100,686,797...100,784,513
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP
ISO
Irinotecan results in increased expression of JUN mRNA
Irinotecan metabolite results in increased expression of JUN mRNA; Irinotecan results in increased expression of JUN mRNA
CTD PMID:15956246 PMID:20097248 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kansl1 KAT8 regulatory NSL complex subunit 1 multiple interactions ISO KANSL1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog] CTD PMID:18927307 NCBI chr10:89,237,667...89,368,735
Ensembl chr10:89,237,667...89,366,951
JBrowse link
G Kat2b lysine acetyltransferase 2B increases expression ISO Irinotecan analog results in increased expression of KAT2B mRNA CTD PMID:18927307 NCBI chr 9:6,562,525...6,667,064 JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 increases expression EXP Irinotecan results in increased expression of KCNJ8 mRNA CTD PMID:20097248 NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603
JBrowse link
G Khdrbs1 KH RNA binding domain containing, signal transduction associated 1 decreases expression ISO Irinotecan analog results in decreased expression of KHDRBS1 mRNA CTD PMID:18927307 NCBI chr 5:142,051,844...142,089,175
Ensembl chr 5:142,063,570...142,089,180
JBrowse link
G Kif14 kinesin family member 14 decreases expression ISO Irinotecan analog results in decreased expression of KIF14 mRNA CTD PMID:18927307 NCBI chr13:47,926,975...47,990,598
Ensembl chr13:47,927,044...47,989,164
JBrowse link
G Klf4 Kruppel like factor 4 increases expression ISO Irinotecan analog results in increased expression of KLF4 mRNA CTD PMID:18927307 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Klf9 Kruppel-like factor 9 increases expression ISO Irinotecan metabolite results in increased expression of KLF9 mRNA; Irinotecan results in increased expression of KLF9 mRNA CTD PMID:15956246 NCBI chr 1:220,700,108...220,725,029
Ensembl chr 1:220,700,108...220,725,037
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO Irinotecan analog results in increased expression of KLHL24 mRNA CTD PMID:18927307 NCBI chr11:80,843,621...80,877,693
Ensembl chr11:80,846,755...80,877,636
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of KNG1 mRNA CTD PMID:16391804 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Knstrn kinetochore-localized astrin/SPAG5 binding protein decreases expression EXP Irinotecan results in decreased expression of KNSTRN mRNA CTD PMID:20097248 NCBI chr 3:105,800,762...105,820,555
Ensembl chr 3:105,800,954...105,820,715
JBrowse link
G Krit1 KRIT1, ankyrin repeat containing decreases expression ISO Irinotecan analog results in decreased expression of KRIT1 mRNA CTD PMID:18927307 NCBI chr 4:30,299,203...30,333,366
Ensembl chr 4:30,299,203...30,333,359
JBrowse link
G Krt18 keratin 18 multiple interactions ISO [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased cleavage of KRT18 protein CTD PMID:15754201 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Krt5 keratin 5 decreases expression ISO Irinotecan metabolite results in decreased expression of KRT5 mRNA; Irinotecan results in decreased expression of KRT5 mRNA CTD PMID:15956246 NCBI chr 7:132,846,355...132,851,986
Ensembl chr 7:132,846,136...132,851,850
JBrowse link
G Lbh LBH regulator of WNT signaling pathway decreases expression ISO Irinotecan analog results in decreased expression of LBH mRNA CTD PMID:18927307 NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079
JBrowse link
G Lgals8 galectin 8 multiple interactions ISO LGALS8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764
JBrowse link
G Lmf1 lipase maturation factor 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of LMF1 mRNA CTD PMID:16391804 NCBI chr10:14,597,726...14,684,071
Ensembl chr10:14,597,594...14,684,119
JBrowse link
G Lmo7 LIM domain 7 affects expression EXP Irinotecan affects the expression of LMO7 mRNA CTD PMID:20097248 NCBI chr15:78,567,029...78,769,833
Ensembl chr15:78,567,023...78,769,783
JBrowse link
G LOC100302372 hypothetical protein LOC100302372 increases expression ISO Irinotecan analog results in increased expression of KIAA0040 mRNA CTD PMID:18927307 NCBI chr13:72,274,519...72,312,103
Ensembl chr13:72,274,552...72,312,103
JBrowse link
G LOC102548162 zinc finger protein 582-like multiple interactions ISO ZNF582 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 1:67,528,191...67,554,970 JBrowse link
G LOC103690190 histone H2A type 1-E decreases expression ISO Irinotecan metabolite results in decreased expression of H2AC6 mRNA; Irinotecan results in decreased expression of H2AC6 mRNA CTD PMID:15956246 NCBI chr17:42,707,863...42,708,420 JBrowse link
G LOC361985 similar to NICE-3 decreases expression ISO Irinotecan analog results in decreased expression of C1ORF43 mRNA CTD PMID:18927307 NCBI chr 2:175,494,355...175,507,276
Ensembl chr 2:175,494,304...175,510,663
JBrowse link
G Loxl3 lysyl oxidase-like 3 decreases expression ISO Irinotecan analog results in decreased expression of LOXL3 mRNA CTD PMID:18927307 NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466
JBrowse link
G Lpcat1 lysophosphatidylcholine acyltransferase 1 decreases expression ISO Irinotecan analog results in decreased expression of LPCAT1 mRNA CTD PMID:18927307 NCBI chr 1:29,766,070...29,816,401
Ensembl chr 1:29,766,071...29,816,401
JBrowse link
G Lrch3 leucine rich repeats and calponin homology domain containing 3 decreases expression ISO Irinotecan analog results in decreased expression of LRCH3 mRNA CTD PMID:18927307 NCBI chr11:67,772,499...67,872,269
Ensembl chr11:67,772,506...67,872,264
JBrowse link
G Lsm7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated increases response to substance ISO LSM7 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 7:8,856,666...8,859,119
Ensembl chr 7:8,856,489...8,859,119
JBrowse link
G Ltf lactotransferrin decreases expression ISO Irinotecan metabolite results in decreased expression of LTF mRNA; Irinotecan results in decreased expression of LTF mRNA CTD PMID:15956246 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
JBrowse link
G Ltv1 LTV1 ribosome biogenesis factor decreases expression ISO Irinotecan analog results in decreased expression of LTV1 mRNA CTD PMID:18927307 NCBI chr 1:7,565,673...7,578,398
Ensembl chr 1:7,565,669...7,578,563
JBrowse link
G Lyz2 lysozyme 2 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of LYZ2 mRNA CTD PMID:32812032 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO Irinotecan metabolite results in decreased expression of MAD2L1 mRNA; Irinotecan results in decreased expression of MAD2L1 mRNA CTD PMID:15956246 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
JBrowse link
G Maf MAF bZIP transcription factor affects expression EXP Irinotecan affects the expression of MAF mRNA CTD PMID:20097248 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 decreases expression EXP Irinotecan results in decreased expression of MAGI1 mRNA CTD PMID:20097248 NCBI chr 4:126,205,667...126,811,354
Ensembl chr 4:126,206,816...126,811,691
JBrowse link
G Mal mal, T-cell differentiation protein increases expression ISO Irinotecan metabolite results in increased expression of MAL mRNA; Irinotecan results in increased expression of MAL mRNA CTD PMID:15956246 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
JBrowse link
G Mall mal, T-cell differentiation protein-like increases expression ISO Irinotecan metabolite results in increased expression of MALL mRNA; Irinotecan results in increased expression of MALL mRNA CTD PMID:15956246 NCBI chr 3:114,927,897...114,950,840
Ensembl chr 3:114,927,897...114,950,785
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Irinotecan metabolite results in decreased expression of MAP3K5 mRNA; Irinotecan results in decreased expression of MAP3K5 mRNA CTD PMID:15956246 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 increases expression EXP Irinotecan results in increased expression of MAP3K6 mRNA CTD PMID:20097248 NCBI chr 5:145,440,126...145,452,213
Ensembl chr 5:145,440,346...145,452,212
JBrowse link
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 decreases expression ISO Irinotecan analog results in decreased expression of MAP4K3 mRNA CTD PMID:18927307 NCBI chr 6:14,276,623...14,446,321
Ensembl chr 6:14,277,121...14,446,334
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression
ISO
EXP
Irinotecan results in increased phosphorylation of and results in increased activity of MAPK1 protein
Irinotecan results in increased expression of MAPK1 mRNA
CTD PMID:16432164 PMID:20097248 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk13 mitogen activated protein kinase 13 affects expression EXP Irinotecan affects the expression of MAPK13 mRNA CTD PMID:20097248 NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Irinotecan results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:16432164 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 increases expression ISO Irinotecan analog results in increased expression of MARCHF6 mRNA CTD PMID:18927307 NCBI chr 2:82,455,686...82,532,917
Ensembl chr 2:82,455,689...82,532,910
JBrowse link
G Matn2 matrilin 2 increases expression ISO Irinotecan analog results in increased expression of MATN2 mRNA CTD PMID:18927307 NCBI chr 7:65,494,996...65,644,613
Ensembl chr 7:65,494,834...65,645,113
JBrowse link
G Matr3 matrin 3 decreases expression ISO Irinotecan analog results in decreased expression of MATR3 mRNA CTD PMID:18927307 NCBI chr18:27,154,098...27,193,212
Ensembl chr18:27,163,714...27,193,166
JBrowse link
G Mbnl1 muscleblind-like splicing regulator 1 decreases expression ISO Irinotecan analog results in decreased expression of MBNL1 mRNA CTD PMID:18927307 NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368
JBrowse link
G Mbp myelin basic protein decreases expression ISO Irinotecan analog results in decreased expression of MBP mRNA CTD PMID:18927307 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mccc2 methylcrotonyl-CoA carboxylase subunit 2 decreases expression
multiple interactions
ISO Irinotecan analog results in decreased expression of MCCC2 mRNA
MCCC2 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:18927307 NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972
JBrowse link
G Mcf2l MCF.2 cell line derived transforming sequence-like decreases expression ISO Irinotecan metabolite results in decreased expression of MCF2L mRNA; Irinotecan results in decreased expression of MCF2L mRNA CTD PMID:15956246 NCBI chr16:76,507,133...76,652,893
Ensembl chr16:76,507,133...76,652,733
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases response to substance ISO MCL1 protein results in decreased susceptibility to Irinotecan CTD PMID:21507240 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO Irinotecan metabolite results in decreased expression of MCM4 mRNA; Irinotecan results in decreased expression of MCM4 mRNA CTD PMID:15956246 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Irinotecan metabolite results in increased expression of MDM2 mRNA; Irinotecan results in increased expression of MDM2 mRNA CTD PMID:15956246 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mdn1 midasin AAA ATPase 1 affects expression ISO Irinotecan analog affects the expression of MDN1 mRNA CTD PMID:18927307 NCBI chr 5:47,055,435...47,190,426
Ensembl chr 5:47,055,447...47,186,332
JBrowse link
G Med13 mediator complex subunit 13 decreases expression ISO Irinotecan analog results in decreased expression of MED13 mRNA CTD PMID:18927307 NCBI chr10:71,086,978...71,176,535
Ensembl chr10:71,090,516...71,177,242
JBrowse link
G Mef2b myocyte enhancer factor 2B increases expression ISO Irinotecan metabolite results in increased expression of MEF2B mRNA; Irinotecan results in increased expression of MEF2B mRNA CTD PMID:15956246 NCBI chr16:19,253,008...19,269,514
Ensembl chr16:19,253,010...19,268,967
JBrowse link
G Mettl7b methyltransferase like 7B affects expression EXP Irinotecan affects the expression of METTL7B mRNA CTD PMID:20097248 NCBI chr 7:1,388,876...1,391,526
Ensembl chr 7:1,388,879...1,391,526
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression
increases response to substance
ISO Irinotecan metabolite results in decreased expression of MGMT mRNA
MGMT mRNA results in increased susceptibility to Irinotecan
CTD PMID:15239142 PMID:18492797 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Minpp1 multiple inositol-polyphosphate phosphatase 1 affects expression EXP Irinotecan affects the expression of MINPP1 mRNA CTD PMID:20097248 NCBI chr 1:230,354,483...230,379,730
Ensembl chr 1:230,354,438...230,379,730
JBrowse link
G Mip major intrinsic protein of lens fiber decreases expression ISO Irinotecan analog results in decreased expression of MIP mRNA CTD PMID:18927307 NCBI chr 7:643,502...654,573
Ensembl chr 7:647,315...654,400
JBrowse link
G Mir128-1 microRNA 128-1 increases expression ISO Irinotecan results in increased expression of MIR128-1 mRNA CTD PMID:22898888 NCBI chr13:39,699,449...39,699,530
Ensembl chr13:39,699,449...39,699,530
JBrowse link
G Mir34a microRNA 34a increases expression ISO Irinotecan results in increased expression of MIR34A mRNA CTD PMID:22898888 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
JBrowse link
G Mir449a microRNA 449a increases expression ISO Irinotecan results in increased expression of MIR449A mRNA CTD PMID:22898888 NCBI chr 2:44,670,714...44,670,804
Ensembl chr 2:44,670,714...44,670,804
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Irinotecan co-treated with rucaparib] results in decreased expression of MKI67 protein CTD PMID:30612311 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mkx mohawk homeobox decreases expression ISO Irinotecan analog results in decreased expression of MKX mRNA CTD PMID:18927307 NCBI chr17:55,077,073...55,156,877
Ensembl chr17:55,077,540...55,156,124
JBrowse link
G Mlh1 mutL homolog 1 affects response to substance ISO MLH1 protein affects the susceptibility to Irinotecan CTD PMID:18949393 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Mlxipl MLX interacting protein-like affects expression EXP Irinotecan affects the expression of MLXIPL mRNA CTD PMID:20097248 NCBI chr12:21,542,964...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Irinotecan metabolite results in increased expression of MMP9 mRNA; Irinotecan results in increased expression of MMP9 mRNA CTD PMID:15956246 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
decreases expression
ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [Irinotecan results in increased activity of MPO protein]]; carvacrol inhibits the reaction [Irinotecan results in increased activity of MPO protein]
Irinotecan metabolite results in decreased expression of MPO mRNA; Irinotecan results in decreased expression of MPO mRNA
CTD PMID:15956246 PMID:27838229 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mpp7 membrane palmitoylated protein 7 increases expression ISO Irinotecan analog results in increased expression of MPP7 mRNA CTD PMID:18927307 NCBI chr17:55,439,939...55,706,810
Ensembl chr17:55,442,696...55,706,748
JBrowse link
G Mpst mercaptopyruvate sulfurtransferase decreases expression ISO Irinotecan results in decreased expression of MPST mRNA CTD PMID:20185912 NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141
JBrowse link
G Mrps30 mitochondrial ribosomal protein S30 decreases expression ISO Irinotecan analog results in decreased expression of MRPS30 mRNA CTD PMID:18927307 NCBI chr 2:50,456,253...50,463,128
Ensembl chr 2:50,456,255...50,463,105
JBrowse link
G Msh2 mutS homolog 2 decreases expression
affects response to substance
ISO Irinotecan metabolite results in decreased expression of MSH2 mRNA; Irinotecan results in decreased expression of MSH2 mRNA
MSH2 protein affects the susceptibility to Irinotecan
CTD PMID:15956246 PMID:18949393 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Msr1 macrophage scavenger receptor 1 increases expression EXP Irinotecan results in increased expression of MSR1 mRNA CTD PMID:20097248 NCBI chr16:52,717,775...52,802,890
Ensembl chr16:52,717,732...52,799,676
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of ATP6 mRNA CTD PMID:16391804 Ensembl chr MT:7,919...8,599 JBrowse link
G Mt1 metallothionein 1 increases expression EXP Irinotecan results in increased expression of MT1A mRNA CTD PMID:20097248 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like decreases expression ISO Irinotecan analog results in decreased expression of MTHFD1L mRNA CTD PMID:18927307 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
JBrowse link
G Mthfs methenyltetrahydrofolate synthetase decreases expression ISO Irinotecan metabolite results in decreased expression of MTHFS mRNA; Irinotecan results in decreased expression of MTHFS mRNA CTD PMID:15956246 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089
JBrowse link
G Mtmr4 myotubularin related protein 4 affects expression EXP Irinotecan affects the expression of MTMR4 mRNA CTD PMID:20097248 NCBI chr10:72,393,411...72,416,342
Ensembl chr10:72,392,551...72,416,342
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases response to substance ISO MYB protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Myh10 myosin heavy chain 10 decreases expression ISO Irinotecan analog results in decreased expression of MYH10 mRNA CTD PMID:18927307 NCBI chr10:53,393,901...53,525,174
Ensembl chr10:53,394,389...53,525,165
JBrowse link
G Mysm1 myb-like, SWIRM and MPN domains 1 decreases expression ISO Irinotecan analog results in decreased expression of MYSM1 mRNA CTD PMID:18927307 NCBI chr 5:109,761,345...109,826,652
Ensembl chr 5:109,776,286...109,819,967
JBrowse link
G N4bp1 Nedd4 binding protein 1 decreases expression ISO Irinotecan analog results in decreased expression of N4BP1 mRNA CTD PMID:18927307 NCBI chr19:20,222,811...20,273,570
Ensembl chr19:20,222,776...20,273,570
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of NCF1 mRNA CTD PMID:32812032 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nck1 NCK adaptor protein 1 decreases expression ISO Irinotecan metabolite results in decreased expression of NCK1 mRNA; Irinotecan results in decreased expression of NCK1 mRNA CTD PMID:15956246 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 increases expression ISO Irinotecan metabolite results in increased expression of NCOA1 mRNA; Irinotecan results in increased expression of NCOA1 mRNA CTD PMID:15956246 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions
decreases expression
ISO NCOR1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
Irinotecan analog results in decreased expression of NCOR1 mRNA
CTD PMID:18927307 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
JBrowse link
G Ncstn nicastrin affects response to substance ISO NCSTN protein affects the susceptibility to Irinotecan CTD PMID:19147571 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
JBrowse link
G Ndrg1 N-myc downstream regulated 1 decreases response to substance ISO NDRG1 protein results in decreased susceptibility to Irinotecan CTD PMID:15867226 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression ISO Irinotecan metabolite results in decreased expression of NEK2 mRNA; Irinotecan results in decreased expression of NEK2 mRNA CTD PMID:15956246 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
increases activity
EXP
ISO
Irinotecan results in increased expression of NFKB1 mRNA
carvacrol inhibits the reaction [Irinotecan results in increased expression of NFKB1 protein]; Silymarin inhibits the reaction [Irinotecan results in increased expression of NFKB1 protein]
Irinotecan results in increased activity of NFKB1 protein
CTD PMID:18182997 PMID:20097248 PMID:27838229 PMID:28454924 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
increases response to substance
multiple interactions
EXP
ISO
Irinotecan results in increased expression of NFKBIA mRNA
NFKBIA gene mutant form results in increased susceptibility to Irinotecan
AS602868 inhibits the reaction [Irinotecan results in increased phosphorylation of and results in decreased expression of NFKBIA protein]; Irinotecan results in increased phosphorylation of and results in decreased expression of NFKBIA protein
CTD PMID:12675310 PMID:18182997 PMID:20097248 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nid1 nidogen 1 increases expression ISO Irinotecan metabolite results in increased expression of NID1 mRNA; Irinotecan results in increased expression of NID1 mRNA CTD PMID:15956246 NCBI chr17:86,085,046...86,158,277
Ensembl chr17:86,085,077...86,158,267
JBrowse link
G Nmu neuromedin U affects expression EXP Irinotecan affects the expression of NMU mRNA CTD PMID:20097248 NCBI chr14:31,844,564...31,872,196
Ensembl chr14:31,844,728...31,872,192
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression ISO Irinotecan analog results in decreased expression of NQO1 mRNA CTD PMID:18927307 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases response to substance ISO NR3C1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects expression EXP Irinotecan affects the expression of NR3C2 mRNA CTD PMID:20097248 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of NRIP1 mRNA CTD PMID:16391804 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase decreases expression ISO Irinotecan analog results in decreased expression of NSF mRNA CTD PMID:18927307 NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
JBrowse link
G Nsmaf neutral sphingomyelinase activation associated factor decreases expression ISO Irinotecan results in decreased expression of NSMAF mRNA CTD PMID:20185912 NCBI chr 5:19,517,795...19,578,773
Ensembl chr 5:19,518,348...19,577,627
JBrowse link
G Nup153 nucleoporin 153 decreases expression ISO Irinotecan analog results in decreased expression of NUP153 mRNA CTD PMID:18927307 NCBI chr17:17,972,217...18,024,876
Ensembl chr17:17,972,217...18,024,876
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 decreases expression ISO
EXP
Irinotecan analog results in decreased expression of NUSAP1 mRNA
Irinotecan results in decreased expression of NUSAP1 mRNA
CTD PMID:18927307 PMID:20097248 NCBI chr 3:106,603,273...106,633,624
Ensembl chr 3:106,603,289...106,633,624
JBrowse link
G Oat ornithine aminotransferase decreases expression EXP Irinotecan results in decreased expression of OAT mRNA CTD PMID:30012503 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
G Ophn1 oligophrenin 1 increases expression ISO Irinotecan analog results in increased expression of OPHN1 mRNA CTD PMID:18927307 NCBI chr  X:63,599,746...63,976,678
Ensembl chr  X:63,603,042...63,976,633
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases response to substance ISO ORC1 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375
JBrowse link
G Osmr oncostatin M receptor decreases response to substance
increases expression
ISO OSMR protein results in decreased susceptibility to Irinotecan
Irinotecan metabolite results in increased expression of OSMR mRNA; Irinotecan results in increased expression of OSMR mRNA
CTD PMID:15956246 PMID:16734730 NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
JBrowse link
G Pag1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 increases expression ISO Irinotecan analog results in increased expression of PAG1 mRNA CTD PMID:18927307 NCBI chr 2:91,935,378...92,076,937
Ensembl chr 2:92,057,216...92,069,849
JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase decreases expression ISO Irinotecan analog results in decreased expression of PAM mRNA CTD PMID:18927307 NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965
JBrowse link
G Pan3 poly(A) specific ribonuclease subunit PAN3 decreases expression ISO Irinotecan analog results in decreased expression of PAN3 mRNA CTD PMID:18927307 NCBI chr12:7,476,707...7,595,380
Ensembl chr12:7,476,697...7,599,204
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions
ISO Irinotecan results in increased expression of PARP1 protein
rucaparib inhibits the reaction [Irinotecan results in increased expression of PARP1 protein]
CTD PMID:30612311 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression ISO Irinotecan results in decreased expression of PAWR mRNA CTD PMID:20185912 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Pax5 paired box 5 decreases expression ISO Irinotecan analog results in decreased expression of PAX5 mRNA CTD PMID:18927307 NCBI chr 5:58,763,334...58,945,719
Ensembl chr 5:58,765,036...58,944,326
JBrowse link
G Pax7 paired box 7 decreases expression ISO Irinotecan analog results in decreased expression of PAX7 mRNA CTD PMID:18927307 NCBI chr 5:151,996,368...152,098,023
Ensembl chr 5:151,999,092...152,097,979
JBrowse link
G Pbxip1 PBX homeobox interacting protein 1 decreases response to substance ISO PBXIP1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:174,856,339...174,868,922
Ensembl chr 2:174,856,397...174,868,919
JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 decreases expression ISO Irinotecan analog results in decreased expression of PCBD2 mRNA CTD PMID:18927307 NCBI chr17:8,845,161...8,896,343 JBrowse link
G Pcdhgc3 protocadherin gamma subfamily C, 3 increases expression ISO Irinotecan metabolite results in increased expression of PCDHGC3 mRNA; Irinotecan results in increased expression of PCDHGC3 mRNA CTD PMID:15956246 NCBI chr18:29,633,016...29,667,865 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 affects expression EXP Irinotecan affects the expression of PCK1 mRNA CTD PMID:20097248 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pclaf PCNA clamp associated factor multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of PCLAF mRNA CTD PMID:16391804 NCBI chr 8:66,420,673...66,432,568
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Irinotecan inhibits the reaction [nitrosobenzylmethylamine results in increased expression of PCNA protein] CTD PMID:15547733 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression
affects expression
ISO
EXP
Irinotecan metabolite results in decreased expression of PDE4B mRNA; Irinotecan results in decreased expression of PDE4B mRNA
Irinotecan affects the expression of PDE4B mRNA
CTD PMID:15956246 PMID:20097248 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pdlim5 PDZ and LIM domain 5 decreases expression ISO Irinotecan analog results in decreased expression of PDLIM5 mRNA CTD PMID:18927307 NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275
JBrowse link
G Pfdn2 prefoldin subunit 2 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of PFDN2 mRNA CTD PMID:32812032 NCBI chr13:83,772,301...83,791,367
Ensembl chr13:83,753,877...83,790,504
JBrowse link
G Pgm2l1 phosphoglucomutase 2-like 1 increases expression ISO Irinotecan analog results in increased expression of PGM2L1 mRNA CTD PMID:18927307 NCBI chr 1:154,571,410...154,620,902
Ensembl chr 1:154,571,766...154,620,902
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO Irinotecan analog results in decreased expression of PHLDA1 mRNA CTD PMID:18927307 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
JBrowse link
G Phlda2 pleckstrin homology-like domain, family A, member 2 increases expression ISO Irinotecan results in increased expression of PHLDA2 mRNA CTD PMID:20185912 NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836
JBrowse link
G Pigw phosphatidylinositol glycan anchor biosynthesis, class W decreases expression ISO Irinotecan analog results in decreased expression of PIGW mRNA CTD PMID:18927307 NCBI chr10:69,746,996...69,782,656
Ensembl chr10:69,748,789...69,790,475
JBrowse link
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta affects expression EXP Irinotecan affects the expression of PIP5K1B mRNA CTD PMID:20097248 NCBI chr 1:221,907,220...222,183,672
Ensembl chr 1:221,914,159...222,183,672
JBrowse link
G Pkdcc protein kinase domain containing, cytoplasmic decreases expression ISO Irinotecan results in decreased expression of PKDCC mRNA CTD PMID:20185912 NCBI chr 6:11,455,686...11,465,002
Ensembl chr 6:11,455,686...11,465,556
JBrowse link
G Pla2g1b phospholipase A2 group IB affects expression EXP Irinotecan affects the expression of PLA2G1B mRNA CTD PMID:20097248 NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226
JBrowse link
G Pla2g2d phospholipase A2, group IID affects expression EXP Irinotecan affects the expression of PLA2G2D mRNA CTD PMID:20097248 NCBI chr 5:151,016,010...151,022,531
Ensembl chr 5:151,018,870...151,022,525
JBrowse link
G Plat plasminogen activator, tissue type increases expression
decreases expression
EXP
ISO
Irinotecan results in increased expression of PLAT mRNA
Irinotecan analog results in decreased expression of PLAT mRNA
CTD PMID:18927307 PMID:20097248 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plcb1 phospholipase C beta 1 decreases expression EXP Irinotecan results in decreased expression of PLCB1 mRNA CTD PMID:20097248 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Plcxd2 phosphatidylinositol-specific phospholipase C, X domain containing 2 increases expression ISO Irinotecan analog results in increased expression of PLCXD2 mRNA CTD PMID:18927307 NCBI chr11:54,800,977...54,853,348
Ensembl chr11:54,789,477...54,853,344
JBrowse link
G Pld1 phospholipase D1 affects expression EXP Irinotecan affects the expression of PLD1 mRNA CTD PMID:20097248 NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Plekha5 pleckstrin homology domain containing A5 decreases expression ISO Irinotecan analog results in decreased expression of PLEKHA5 mRNA CTD PMID:18927307 NCBI chr 4:173,333,891...173,503,546
Ensembl chr 4:173,334,055...173,503,546
JBrowse link
G Plekhh3 pleckstrin homology, MyTH4 and FERM domain containing H3 increases expression ISO Irinotecan metabolite results in increased expression of PLEKHH3 mRNA; Irinotecan results in increased expression of PLEKHH3 mRNA CTD PMID:15956246 NCBI chr10:86,098,461...86,106,931
Ensembl chr10:86,098,469...86,106,880
JBrowse link
G Plk1 polo-like kinase 1 decreases expression ISO Irinotecan metabolite results in decreased expression of PLK1 mRNA; Irinotecan results in decreased expression of PLK1 mRNA CTD PMID:15956246 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Irinotecan metabolite results in increased expression of PLK2 mRNA; Irinotecan results in increased expression of PLK2 mRNA CTD PMID:15956246 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO Irinotecan metabolite results in increased expression of PLK3 mRNA; Irinotecan results in increased expression of PLK3 mRNA CTD PMID:15956246 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
JBrowse link
G Plpp1 phospholipid phosphatase 1 decreases response to substance ISO PLPP1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:44,439,002...44,500,430
Ensembl chr 2:44,438,994...44,501,268
JBrowse link
G Plrg1 pleiotropic regulator 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of PLRG1 mRNA CTD PMID:16391804 NCBI chr 2:168,408,139...168,424,470
Ensembl chr 2:168,408,124...168,424,522
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Irinotecan metabolite results in increased expression of PMAIP1 mRNA; Irinotecan results in increased expression of PMAIP1 mRNA CTD PMID:15956246 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Pmp22 peripheral myelin protein 22 affects expression EXP Irinotecan affects the expression of PMP22 mRNA CTD PMID:20097248 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
JBrowse link
G Pnrc1 proline-rich nuclear receptor coactivator 1 increases expression ISO Irinotecan analog results in increased expression of PNRC1 mRNA CTD PMID:18927307 NCBI chr 5:47,647,070...47,657,832
Ensembl chr 5:47,647,071...47,650,161
JBrowse link
G Pogz pogo transposable element derived with ZNF domain decreases expression ISO Irinotecan analog results in decreased expression of POGZ mRNA CTD PMID:18927307 NCBI chr 2:182,394,269...182,440,711
Ensembl chr 2:182,380,768...182,440,707
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit increases response to substance
affects expression
ISO
EXP
POLA1 protein results in increased susceptibility to Irinotecan
Irinotecan affects the expression of POLA1 mRNA
CTD PMID:16734730 PMID:20097248 NCBI chr  X:58,034,617...58,348,612
Ensembl chr  X:58,034,619...58,348,536
JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit increases response to substance ISO POLE2 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305
JBrowse link
G Polk DNA polymerase kappa decreases expression ISO Irinotecan analog results in decreased expression of POLK mRNA CTD PMID:18927307 NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313
JBrowse link
G Polr3g RNA polymerase III subunit G increases response to substance ISO POLR3G protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:11,945,215...11,986,125
Ensembl chr 2:11,945,217...11,986,125
JBrowse link
G Pon3 paraoxonase 3 affects expression EXP Irinotecan affects the expression of PON3 mRNA CTD PMID:20097248 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
JBrowse link
G Por cytochrome p450 oxidoreductase increases response to substance ISO POR mRNA results in increased susceptibility to Irinotecan CTD PMID:15239142 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D increases expression ISO Irinotecan analog results in increased expression of PPM1D mRNA CTD PMID:18927307 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha decreases expression
multiple interactions
ISO Irinotecan analog results in decreased expression of PPP3CA mRNA
[Fluorouracil co-treated with Irinotecan] results in increased expression of PPP3CA mRNA; PPP3CA protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:16391804 PMID:18927307 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta decreases expression ISO Irinotecan metabolite results in decreased expression of PPP3CB mRNA; Irinotecan results in decreased expression of PPP3CB mRNA CTD PMID:15956246 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
JBrowse link
G Ppp4r3b protein phosphatase 4, regulatory subunit 3B decreases expression ISO Irinotecan analog results in decreased expression of PPP4R3B mRNA CTD PMID:18927307 NCBI chr14:102,917,043...102,965,210
Ensembl chr14:102,917,443...103,068,192
JBrowse link
G Prap1 proline-rich acidic protein 1 affects expression EXP Irinotecan affects the expression of PRAP1 mRNA CTD PMID:20097248 NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 decreases expression ISO Irinotecan analog results in decreased expression of PRKAA1 mRNA CTD PMID:18927307 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkca protein kinase C, alpha increases phosphorylation ISO Irinotecan metabolite results in increased phosphorylation of PRKCA protein; Irinotecan results in increased phosphorylation of PRKCA protein CTD PMID:15723263 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcb protein kinase C, beta increases phosphorylation ISO Irinotecan metabolite results in increased phosphorylation of PRKCB protein; Irinotecan results in increased phosphorylation of PRKCB protein CTD PMID:15723263 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkcd protein kinase C, delta increases phosphorylation ISO Irinotecan metabolite results in increased phosphorylation of PRKCD protein; Irinotecan results in increased phosphorylation of PRKCD protein CTD PMID:15723263 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkci protein kinase C, iota increases phosphorylation ISO Irinotecan metabolite results in increased phosphorylation of PRKCI protein; Irinotecan results in increased phosphorylation of PRKCI protein CTD PMID:15723263 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit multiple interactions
increases phosphorylation
ISO IC486241 inhibits the reaction [Irinotecan results in increased phosphorylation of PRKDC protein] CTD PMID:17441964 PMID:21221710 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Prlr prolactin receptor affects expression EXP Irinotecan affects the expression of PRLR mRNA CTD PMID:20097248 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
JBrowse link
G Prom1 prominin 1 decreases expression ISO Irinotecan metabolite results in decreased expression of PROM1 mRNA; Irinotecan results in decreased expression of PROM1 mRNA CTD PMID:15956246 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G Prr13 proline rich 13 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of PRR13 mRNA CTD PMID:16391804 NCBI chr 7:133,592,511...133,595,817
Ensembl chr 7:133,592,490...133,601,005
JBrowse link
G Prr15 proline rich 15 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of PRR15 mRNA CTD PMID:32812032 NCBI chr 4:83,432,002...83,435,582
Ensembl chr 4:83,431,758...83,437,436
JBrowse link
G Prss12 serine protease 12 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of PRSS12 mRNA CTD PMID:32812032 NCBI chr 2:211,624,134...211,684,126
Ensembl chr 2:211,624,134...211,684,126
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases response to substance ISO PSAT1 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
JBrowse link
G Ptch1 patched 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of PTCH1 mRNA CTD PMID:16391804 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
JBrowse link
G Ptges prostaglandin E synthase increases expression ISO Irinotecan metabolite results in increased expression of PTGES mRNA; Irinotecan results in increased expression of PTGES mRNA CTD PMID:15956246 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Irinotecan results in increased expression of PTGS2 protein
carvacrol inhibits the reaction [Irinotecan results in increased expression of PTGS2 protein]
CTD PMID:27838229 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression ISO Irinotecan analog results in decreased expression of PTK2 mRNA CTD PMID:18927307 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 decreases expression ISO Irinotecan analog results in decreased expression of PTP4A1 mRNA CTD PMID:18927307 NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 decreases expression ISO Irinotecan metabolite results in decreased expression of PTPN13 mRNA; Irinotecan results in decreased expression of PTPN13 mRNA CTD PMID:15956246 NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 increases expression ISO Irinotecan metabolite results in increased expression of PTPN22 mRNA; Irinotecan results in increased expression of PTPN22 mRNA CTD PMID:15956246 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D increases expression ISO Irinotecan metabolite results in increased expression of PTPRD mRNA; Irinotecan results in increased expression of PTPRD mRNA CTD PMID:15956246 NCBI chr 5:90,046,993...90,698,977
Ensembl chr 5:90,048,966...92,369,396
JBrowse link
G Ptprg protein tyrosine phosphatase, receptor type, G decreases expression ISO Irinotecan analog results in decreased expression of PTPRG mRNA CTD PMID:18927307 NCBI chr15:12,872,284...13,552,186
Ensembl chr15:12,871,721...13,554,094
JBrowse link
G Ptprn protein tyrosine phosphatase, receptor type, N increases expression ISO Irinotecan metabolite results in increased expression of PTPRN mRNA; Irinotecan results in increased expression of PTPRN mRNA CTD PMID:15956246 NCBI chr 9:76,741,010...76,756,704
Ensembl chr 9:76,741,016...76,756,190
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin affects expression EXP Irinotecan affects the expression of PTTG1 mRNA CTD PMID:20097248 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
JBrowse link
G Rab27a RAB27A, member RAS oncogene family affects expression EXP Irinotecan affects the expression of RAB27A mRNA CTD PMID:20097248 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829
JBrowse link
G Rab31 RAB31, member RAS oncogene family decreases response to substance ISO RAB31 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 9:105,246,712...105,382,973
Ensembl chr 9:105,246,709...105,381,253
JBrowse link
G Rac3 Rac family small GTPase 3 increases expression ISO Irinotecan metabolite results in increased expression of RAC3 mRNA; Irinotecan results in increased expression of RAC3 mRNA CTD PMID:15956246 NCBI chr10:106,002,808...106,005,244 JBrowse link
G Rad23b RAD23 homolog B, nucleotide excision repair protein decreases expression ISO Irinotecan metabolite results in decreased expression of RAD23B mRNA; Irinotecan results in decreased expression of RAD23B mRNA CTD PMID:15956246 NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319
JBrowse link
G Rad51 RAD51 recombinase increases expression
multiple interactions
ISO Irinotecan results in increased expression of RAD51 protein
[Irinotecan co-treated with 2-(morpholin-4-yl)benzo(h)chromen-4-one] results in increased expression of RAD51 protein; [Irinotecan co-treated with IC486241] results in increased expression of RAD51 protein
CTD PMID:21221710 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Ramp1 receptor activity modifying protein 1 affects expression EXP Irinotecan affects the expression of RAMP1 mRNA CTD PMID:20097248 NCBI chr 9:91,765,481...91,816,152
Ensembl chr 9:91,781,285...91,816,151
JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression EXP Irinotecan results in increased expression of RARRES1 mRNA CTD PMID:20097248 NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978
JBrowse link
G Rasa1 RAS p21 protein activator 1 decreases expression ISO Irinotecan analog results in decreased expression of RASA1 mRNA CTD PMID:18927307 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects expression ISO Irinotecan affects the expression of RB1 protein CTD PMID:15132777 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit decreases expression
increases expression
ISO Irinotecan metabolite results in decreased expression of RBBP5 mRNA; Irinotecan results in decreased expression of RBBP5 mRNA
Irinotecan metabolite results in increased expression of RBBP5 mRNA; Irinotecan results in increased expression of RBBP5 mRNA
CTD PMID:15956246 NCBI chr13:43,912,254...43,939,107
Ensembl chr13:43,912,254...43,939,107
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO Irinotecan metabolite results in decreased expression of RBL1 mRNA; Irinotecan results in decreased expression of RBL1 mRNA CTD PMID:15956246 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
JBrowse link
G Rbm24 RNA binding motif protein 24 increases expression ISO Irinotecan analog results in increased expression of RBM24 mRNA CTD PMID:18927307 NCBI chr17:18,275,681...18,288,231
Ensembl chr17:18,275,688...18,288,102
JBrowse link
G Rbms1 RNA binding motif, single stranded interacting protein 1 decreases response to substance ISO RBMS1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 3:45,195,828...45,420,406
Ensembl chr 3:45,197,972...45,420,376
JBrowse link
G Rbp2 retinol binding protein 2 affects expression EXP Irinotecan affects the expression of RBP2 mRNA CTD PMID:20097248 NCBI chr 8:99,079,293...99,104,489
Ensembl chr 8:99,079,104...99,104,473
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region multiple interactions
decreases expression
ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of RBPJ mRNA
Irinotecan analog results in decreased expression of RBPJ mRNA
CTD PMID:16391804 PMID:18927307 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs increases expression ISO Irinotecan analog results in increased expression of RECK mRNA CTD PMID:18927307 NCBI chr 5:58,102,915...58,169,513
Ensembl chr 5:58,102,981...58,169,502
JBrowse link
G Reg1a regenerating family member 1 alpha affects expression EXP Irinotecan affects the expression of REG1A mRNA CTD PMID:20097248 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570
JBrowse link
G Reg3b regenerating family member 3 beta affects expression EXP Irinotecan affects the expression of REG3B mRNA CTD PMID:20097248 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
JBrowse link
G Reg3g regenerating family member 3 gamma affects expression EXP Irinotecan affects the expression of REG3G mRNA CTD PMID:20097248 NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression
increases activity
decreases response to substance
multiple interactions
EXP
ISO
Irinotecan results in increased expression of RELA protein
Irinotecan results in increased activity of RELA protein
RELA protein results in decreased susceptibility to Irinotecan
[Irinotecan co-treated with Thalidomide co-treated with Celecoxib] results in increased expression of RELA protein; [Irinotecan co-treated with Thalidomide] results in increased expression of RELA protein
CTD PMID:15161687 PMID:16685529 PMID:18182997 PMID:18535404 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Reps1 RALBP1 associated Eps domain containing 1 multiple interactions
decreases expression
ISO REPS1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
Irinotecan analog results in decreased expression of REPS1 mRNA
CTD PMID:18927307 NCBI chr 1:12,698,107...12,775,561
Ensembl chr 1:12,697,747...12,775,561
JBrowse link
G Rfc3 replication factor C subunit 3 increases response to substance
decreases expression
ISO RFC3 protein results in increased susceptibility to Irinotecan
Irinotecan metabolite results in decreased expression of RFC3 mRNA; Irinotecan results in decreased expression of RFC3 mRNA
CTD PMID:15956246 PMID:16734730 NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778
JBrowse link
G RGD1308706 similar to RIKEN cDNA 4921524J17 decreases expression ISO Irinotecan analog results in decreased expression of C16ORF87 mRNA CTD PMID:18927307 NCBI chr19:21,626,390...21,653,869
Ensembl chr19:21,626,914...21,654,255
JBrowse link
G RGD1563323 similar to hypothetical protein FLJ22531 increases expression ISO Irinotecan analog results in increased expression of C11ORF80 mRNA CTD PMID:18927307 NCBI chr 1:201,902,564...201,989,945 JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO Irinotecan metabolite results in increased expression of RGS1 mRNA; Irinotecan results in increased expression of RGS1 mRNA CTD PMID:15956246 NCBI chr13:56,018,529...56,022,939
Ensembl chr13:56,018,554...56,022,984
JBrowse link
G Rgs10 regulator of G-protein signaling 10 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of RGS10 mRNA CTD PMID:32812032 NCBI chr 1:182,946,334...182,987,729
Ensembl chr 1:182,946,336...182,987,697
JBrowse link
G Rgs22 regulator of G-protein signaling 22 decreases expression ISO Irinotecan analog results in decreased expression of RGS22 mRNA CTD PMID:18927307 NCBI chr 7:67,188,531...67,308,805
Ensembl chr 7:67,188,519...67,308,875
JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression EXP Irinotecan results in increased expression of RGS4 mRNA CTD PMID:20097248 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Rhob ras homolog family member B increases expression ISO Irinotecan results in increased expression of RHOB mRNA CTD PMID:20185912 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Rhou ras homolog family member U increases expression ISO Irinotecan analog results in increased expression of RHOU mRNA CTD PMID:18927307 NCBI chr19:51,641,408...51,651,249 JBrowse link
G Rlim ring finger protein, LIM domain interacting decreases expression ISO Irinotecan analog results in decreased expression of RLIM mRNA CTD PMID:18927307 NCBI chr  X:68,983,259...69,004,368
Ensembl chr  X:68,988,375...69,004,271
JBrowse link
G Rnf34 ring finger protein 34 multiple interactions
decreases response to substance
ISO RNF34 protein inhibits the reaction [Irinotecan results in increased activity of CASP3 protein]
RNF34 protein results in decreased susceptibility to Irinotecan
CTD PMID:16080519 NCBI chr12:33,703,655...33,724,606
Ensembl chr12:33,703,673...33,724,586
JBrowse link
G Rpl4 ribosomal protein L4 decreases expression ISO Irinotecan analog results in decreased expression of RPL4 mRNA CTD PMID:18927307 NCBI chr 8:64,671,177...64,676,301
Ensembl chr 8:64,671,160...64,676,306
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [Irinotecan co-treated with rucaparib] results in decreased expression of RPS6KB1 protein CTD PMID:30612311 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases expression ISO Irinotecan analog results in increased expression of HLA-DRB1 mRNA CTD PMID:18927307 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G Rtp4 receptor (chemosensory) transporter protein 4 affects expression EXP Irinotecan affects the expression of RTP4 mRNA CTD PMID:20097248 NCBI chr11:77,237,341...77,249,194
Ensembl chr11:77,238,216...77,335,437
JBrowse link
G Runx1 RUNX family transcription factor 1 decreases expression ISO Irinotecan metabolite results in decreased expression of RUNX1 mRNA; Irinotecan results in decreased expression of RUNX1 mRNA CTD PMID:15956246 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G S100g S100 calcium binding protein G affects expression EXP Irinotecan affects the expression of S100G mRNA CTD PMID:20097248 NCBI chr  X:31,705,853...31,708,422
Ensembl chr  X:31,705,866...31,708,433
JBrowse link
G Samd9 sterile alpha motif domain containing 9 increases expression ISO Irinotecan analog results in increased expression of SAMD9 mRNA CTD PMID:18927307 NCBI chr 4:31,164,639...31,184,325
Ensembl chr 4:31,164,510...31,184,322
JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 affects expression ISO Irinotecan analog affects the expression of SAMHD1 mRNA CTD PMID:18927307 NCBI chr 3:145,761,549...145,794,420
Ensembl chr 3:145,761,558...145,794,386
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 decreases response to substance
increases expression
ISO SAT1 mRNA results in decreased susceptibility to Irinotecan
Irinotecan results in increased expression of SAT1 mRNA
CTD PMID:15152939 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link
G Scaf4 SR-related CTD-associated factor 4 decreases expression ISO Irinotecan analog results in decreased expression of SCAF4 mRNA CTD PMID:18927307 NCBI chr11:29,460,479...29,521,153
Ensembl chr11:29,465,106...29,521,153
JBrowse link
G Scai suppressor of cancer cell invasion decreases expression ISO Irinotecan analog results in decreased expression of SCAI mRNA CTD PMID:18927307 NCBI chr 3:22,813,283...22,925,364
Ensembl chr 3:22,819,574...22,925,363
JBrowse link
G Scamp3 secretory carrier membrane protein 3 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of SCAMP3 mRNA CTD PMID:16391804 NCBI chr 2:174,583,124...174,588,984 JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Irinotecan analog results in increased expression of SCD4 mRNA CTD PMID:18927307 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Scin scinderin affects expression EXP Irinotecan affects the expression of SCIN mRNA CTD PMID:20097248 NCBI chr 6:57,110,128...57,188,059
Ensembl chr 6:57,109,403...57,188,242
JBrowse link
G Sdc4 syndecan 4 increases expression ISO Irinotecan metabolite results in increased expression of SDC4 mRNA; Irinotecan results in increased expression of SDC4 mRNA CTD PMID:15956246 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
JBrowse link
G Sec31a SEC31 homolog A, COPII coat complex component decreases expression ISO Irinotecan analog results in decreased expression of SEC31A mRNA CTD PMID:18927307 NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273
JBrowse link
G Sema3c semaphorin 3C increases expression ISO Irinotecan analog results in increased expression of SEMA3C mRNA CTD PMID:18927307 NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534
JBrowse link
G Senp6 SUMO specific peptidase 6 decreases expression ISO Irinotecan analog results in decreased expression of SENP6 mRNA CTD PMID:18927307 NCBI chr 8:80,988,675...81,071,606
Ensembl chr 8:80,989,052...81,067,170
JBrowse link
G Serpinb5 serpin family B member 5 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of SERPINB5 mRNA CTD PMID:16391804 NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO SERPINE2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
JBrowse link
G Sertad1 SERTA domain containing 1 increases expression ISO Irinotecan results in increased expression of SERTAD1 mRNA CTD PMID:20185912 NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091
JBrowse link
G Sesn2 sestrin 2 increases expression ISO Irinotecan metabolite results in increased expression of SESN2 mRNA; Irinotecan results in increased expression of SESN2 mRNA CTD PMID:15956246 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Setd1b SET domain containing 1B, histone lysine methyltransferase decreases expression ISO Irinotecan analog results in decreased expression of SETD1B mRNA CTD PMID:18927307 NCBI chr12:33,395,963...33,421,671
Ensembl chr12:33,396,120...33,426,934
JBrowse link
G Setd5 SET domain containing 5 decreases expression ISO Irinotecan analog results in decreased expression of SETD5 mRNA CTD PMID:18927307 NCBI chr 4:146,217,172...146,294,896
Ensembl chr 4:146,217,180...146,294,894
JBrowse link
G Sfn stratifin multiple interactions ISO [Irinotecan co-treated with Bortezomib] results in decreased expression of SFN protein CTD PMID:16373703 Ensembl chr 5:145,826,201...145,831,314 JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Irinotecan analog results in increased expression of SGK1 mRNA; Irinotecan metabolite results in increased expression of SGK1 mRNA; Irinotecan results in increased expression of SGK1 mRNA CTD PMID:15956246 PMID:18927307 PMID:20185912 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Sgo2 shugoshin 2 decreases expression ISO Irinotecan analog results in decreased expression of SGO2 mRNA CTD PMID:18927307 NCBI chr 9:59,548,605...59,573,229
Ensembl chr 9:59,548,683...59,573,229
JBrowse link
G Siglec1 sialic acid binding Ig like lectin 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of SIGLEC1 mRNA CTD PMID:16391804 NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850
JBrowse link
G Skp2 S-phase kinase associated protein 2 increases response to substance ISO SKP2 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
JBrowse link
G Slc13a2 solute carrier family 13 member 2 affects expression EXP Irinotecan affects the expression of SLC13A2 mRNA CTD PMID:20097248 NCBI chr10:63,291,813...63,319,127
Ensembl chr10:63,291,815...63,319,127
JBrowse link
G Slc16a4 solute carrier family 16, member 4 decreases expression ISO Irinotecan metabolite results in decreased expression of SLC16A4 mRNA; Irinotecan results in decreased expression of SLC16A4 mRNA CTD PMID:15956246 NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117
JBrowse link
G Slc19a1 solute carrier family 19 member 1 decreases expression ISO Irinotecan analog results in decreased expression of SLC19A1 mRNA CTD PMID:18927307 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
JBrowse link
G Slc25a21 solute carrier family 25 member 21 decreases expression ISO Irinotecan analog results in decreased expression of SLC25A21 mRNA CTD PMID:18927307 NCBI chr 6:74,203,439...74,702,902
Ensembl chr 6:74,203,440...74,702,680
JBrowse link
G Slc25a36 solute carrier family 25 member 36 affects expression EXP Irinotecan affects the expression of SLC25A36 mRNA CTD PMID:20097248 NCBI chr 8:97,659,848...97,693,735
Ensembl chr 8:97,662,127...97,693,703
JBrowse link
G Slc30a1 solute carrier family 30 member 1 decreases expression ISO Irinotecan analog results in decreased expression of SLC30A1 mRNA CTD PMID:18927307 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
JBrowse link
G Slc31a1 solute carrier family 31 member 1 affects expression EXP Irinotecan affects the expression of SLC31A1 mRNA CTD PMID:20097248 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
JBrowse link
G Slc39a4 solute carrier family 39 member 4 affects expression EXP Irinotecan affects the expression of SLC39A4 mRNA CTD PMID:20097248 NCBI chr 7:108,333,380...108,337,553
Ensembl chr 7:108,333,381...108,337,553
JBrowse link
G Slc44a1 solute carrier family 44 member 1 affects expression EXP Irinotecan affects the expression of SLC44A1 mRNA CTD PMID:20097248 NCBI chr 5:68,061,941...68,241,912
Ensembl chr 5:68,063,618...68,241,909
JBrowse link
G Slc9a3r2 SLC9A3 regulator 2 increases expression ISO Irinotecan metabolite results in increased expression of SLC9A3R2 mRNA; Irinotecan results in increased expression of SLC9A3R2 mRNA CTD PMID:15956246 NCBI chr10:13,662,461...13,672,975
Ensembl chr10:13,662,461...13,673,049
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Irinotecan inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor affects expression EXP Irinotecan affects the expression of SLPI mRNA CTD PMID:20097248 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Smad3 SMAD family member 3 decreases expression ISO Irinotecan analog results in decreased expression of SMAD3 mRNA CTD PMID:18927307 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 decreases expression ISO Irinotecan analog results in decreased expression of SMCHD1 mRNA CTD PMID:18927307 NCBI chr 9:111,243,445...111,387,272
Ensembl chr 9:111,247,702...111,349,665
JBrowse link
G Smu1 SMU1, DNA replication regulator and spliceosomal factor decreases expression ISO Irinotecan analog results in decreased expression of SMU1 mRNA CTD PMID:18927307 NCBI chr 5:55,856,691...55,875,262
Ensembl chr 5:55,856,246...55,875,300
JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 affects expression ISO Irinotecan analog affects the expression of SMURF1 mRNA CTD PMID:18927307 NCBI chr12:9,635,009...9,726,520
Ensembl chr12:9,635,025...9,726,519
JBrowse link
G Snrpa1 small nuclear ribonucleoprotein polypeptide A' multiple interactions
decreases expression
ISO SNRPA1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
Irinotecan analog results in decreased expression of SNRPA1 mRNA
CTD PMID:18927307 NCBI chr 1:119,641,402...119,654,653
Ensembl chr 1:119,638,481...119,654,653
JBrowse link
G Snrpf small nuclear ribonucleoprotein polypeptide F increases response to substance ISO SNRPF protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 7:28,130,427...28,137,129
Ensembl chr 7:28,130,427...28,137,129
JBrowse link
G Snx18 sorting nexin 18 decreases expression ISO Irinotecan metabolite results in decreased expression of SNX18 mRNA; Irinotecan results in decreased expression of SNX18 mRNA CTD PMID:15956246 NCBI chr 2:45,232,325...45,258,345
Ensembl chr 2:45,232,325...45,258,345
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Irinotecan co-treated with Fluorouracil] results in increased activity of SOD2 protein CTD PMID:15886469 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sp1 Sp1 transcription factor decreases expression
increases phosphorylation
multiple interactions
ISO Irinotecan analog results in decreased expression of SP1 mRNA
Irinotecan results in increased phosphorylation of SP1 protein
SP1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:17441964 PMID:18927307 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sphk1 sphingosine kinase 1 affects expression EXP Irinotecan affects the expression of SPHK1 mRNA CTD PMID:20097248 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Spib Spi-B transcription factor increases expression ISO Irinotecan metabolite results in increased expression of SPIB mRNA; Irinotecan results in increased expression of SPIB mRNA CTD PMID:15956246 NCBI chr 1:95,018,939...95,024,804
Ensembl chr 1:95,018,947...95,024,780
JBrowse link
G Srp19 signal recognition particle 19 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of SRP19 mRNA CTD PMID:16391804 NCBI chr18:25,931,734...25,937,974
Ensembl chr18:25,931,589...25,938,017
JBrowse link
G Srpx sushi-repeat-containing protein, X-linked increases expression EXP Irinotecan results in increased expression of SRPX mRNA CTD PMID:20097248 NCBI chr  X:12,676,984...12,751,296 JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases phosphorylation
multiple interactions
ISO Irinotecan results in increased phosphorylation of STAT1 protein
STAT1 protein promotes the reaction [Irinotecan results in increased localization of FAS protein]; TP53 protein inhibits the reaction [Irinotecan results in increased phosphorylation of STAT1 protein]
CTD PMID:16204068 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stk25 serine/threonine kinase 25 affects expression EXP Irinotecan affects the expression of STK25 mRNA CTD PMID:20097248 NCBI chr 9:94,161,834...94,174,095
Ensembl chr 9:94,161,836...94,174,244
JBrowse link
G Stk38 serine/threonine kinase 38 increases expression ISO Irinotecan metabolite results in increased expression of STK38 mRNA; Irinotecan results in increased expression of STK38 mRNA CTD PMID:15956246 NCBI chr20:7,034,245...7,067,803
Ensembl chr20:7,034,242...7,068,198
JBrowse link
G Stk4 serine/threonine kinase 4 decreases expression
multiple interactions
ISO Irinotecan analog results in decreased expression of STK4 mRNA; Irinotecan metabolite results in decreased expression of STK4 mRNA; Irinotecan results in decreased expression of STK4 mRNA
STK4 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:15956246 PMID:18927307 NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744
JBrowse link
G Stx5 syntaxin 5 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of STX5 mRNA CTD PMID:16391804 NCBI chr 1:205,637,401...205,653,563
Ensembl chr 1:205,637,413...205,653,563
JBrowse link
G Syde2 synapse defective Rho GTPase homolog 2 increases expression ISO Irinotecan analog results in increased expression of SYDE2 mRNA CTD PMID:18927307 NCBI chr 2:234,897,975...234,930,994
Ensembl chr 2:234,897,717...234,930,994
JBrowse link
G Syt1 synaptotagmin 1 decreases expression ISO Irinotecan analog results in decreased expression of SYT1 mRNA CTD PMID:18927307 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
JBrowse link
G Taf2 TATA-box binding protein associated factor 2 decreases expression ISO Irinotecan metabolite results in decreased expression of TAF2 mRNA; Irinotecan results in decreased expression of TAF2 mRNA CTD PMID:15956246 NCBI chr 7:86,422,613...86,479,616
Ensembl chr 7:86,422,613...86,479,616
JBrowse link
G Taf5l TATA-box binding protein associated factor 5 like multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of TAF5L mRNA CTD PMID:16391804 NCBI chr19:51,991,704...52,011,001
Ensembl chr19:51,991,708...52,011,295
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of TARDBP mRNA CTD PMID:32812032 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
JBrowse link
G Tbcc tubulin folding cofactor C increases expression ISO Irinotecan metabolite results in increased expression of TBCC mRNA; Irinotecan results in increased expression of TBCC mRNA CTD PMID:15956246 PMID:20185912 NCBI chr 9:14,098,875...14,100,026
Ensembl chr 9:14,098,868...14,100,042
JBrowse link
G Tcf12 transcription factor 12 decreases expression ISO Irinotecan analog results in decreased expression of TCF12 mRNA CTD PMID:18927307 NCBI chr 8:72,490,447...72,799,265
Ensembl chr 8:72,492,567...72,799,201
JBrowse link
G Tcf7l2 transcription factor 7 like 2 decreases expression ISO Irinotecan analog results in decreased expression of TCF7L2 mRNA CTD PMID:18927307 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967
JBrowse link
G Tesk2 testis associated actin remodelling kinase 2 affects expression EXP Irinotecan affects the expression of TESK2 mRNA CTD PMID:20097248 NCBI chr 5:130,178,715...130,270,594
Ensembl chr 5:130,185,033...130,271,292
JBrowse link
G Tfcp2 transcription factor CP2 decreases expression ISO Irinotecan analog results in decreased expression of TFCP2 mRNA CTD PMID:18927307 NCBI chr 7:131,616,777...131,658,995
Ensembl chr 7:131,616,785...131,658,939
JBrowse link
G Tff1 trefoil factor 1 affects expression EXP Irinotecan affects the expression of TFF1 mRNA CTD PMID:20097248 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tff3 trefoil factor 3 affects expression EXP Irinotecan affects the expression of TFF3 mRNA CTD PMID:20097248 NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054
JBrowse link
G Tfpi tissue factor pathway inhibitor decreases expression ISO Irinotecan analog results in decreased expression of TFPI mRNA CTD PMID:18927307 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
JBrowse link
G Tfrc transferrin receptor increases expression ISO Irinotecan analog results in increased expression of TFRC mRNA CTD PMID:18927307 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions
increases secretion
decreases response to substance
ISO Gefitinib inhibits the reaction [Irinotecan metabolite results in increased secretion of TGFA protein]; Gefitinib inhibits the reaction [Irinotecan results in increased secretion of TGFA protein]; rottlerin inhibits the reaction [Irinotecan metabolite results in increased secretion of TGFA protein]; rottlerin inhibits the reaction [Irinotecan results in increased secretion of TGFA protein]
Irinotecan metabolite results in increased secretion of TGFA protein; Irinotecan results in increased secretion of TGFA protein
TGFA protein results in decreased susceptibility to Irinotecan
CTD PMID:15723263 PMID:16734730 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tgfbi transforming growth factor, beta induced decreases expression ISO Irinotecan analog results in decreased expression of TGFBI mRNA CTD PMID:18927307 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240
JBrowse link
G Thbs1 thrombospondin 1 decreases response to substance ISO THBS1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Thbs2 thrombospondin 2 increases expression EXP Irinotecan results in increased expression of THBS2 mRNA CTD PMID:20097248 NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789
JBrowse link
G Them4 thioesterase superfamily member 4 decreases expression ISO Irinotecan analog results in decreased expression of THEM4 mRNA CTD PMID:18927307 NCBI chr 2:181,953,550...181,974,708
Ensembl chr 2:181,953,550...181,974,708
JBrowse link
G Thnsl1 threonine synthase-like 1 decreases expression ISO Irinotecan analog results in decreased expression of THNSL1 mRNA CTD PMID:18927307 NCBI chr17:83,714,794...83,722,190
Ensembl chr17:83,714,738...83,723,805
JBrowse link
G Thrap3 thyroid hormone receptor associated protein 3 decreases expression ISO Irinotecan analog results in decreased expression of THRAP3 mRNA CTD PMID:18927307 NCBI chr 5:138,445,284...138,487,544
Ensembl chr 5:138,445,295...138,487,477
JBrowse link
G Thy1 Thy-1 cell surface antigen increases expression ISO Irinotecan metabolite results in increased expression of THY1 mRNA; Irinotecan results in increased expression of THY1 mRNA CTD PMID:15956246 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions
ISO Irinotecan results in increased expression of TLR4 protein
Silymarin inhibits the reaction [Irinotecan results in increased expression of TLR4 protein]
CTD PMID:28454924 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tmem123 transmembrane protein 123 decreases expression ISO Irinotecan analog results in decreased expression of TMEM123 mRNA CTD PMID:18927307 NCBI chr 8:4,922,098...4,952,228
Ensembl chr 8:4,922,098...4,952,224
JBrowse link
G Tmem267 transmembrane protein 267 decreases expression ISO Irinotecan analog results in decreased expression of TMEM267 mRNA CTD PMID:18927307 NCBI chr 2:51,580,210...51,588,937 JBrowse link
G Tmem37 transmembrane protein 37 affects expression EXP Irinotecan affects the expression of TMEM37 mRNA CTD PMID:20097248 NCBI chr13:31,184,322...31,191,477
Ensembl chr13:31,171,355...31,191,077
JBrowse link
G Tmem41b transmembrane protein 41B decreases expression ISO Irinotecan metabolite results in decreased expression of TMEM41B mRNA; Irinotecan results in decreased expression of TMEM41B mRNA CTD PMID:15956246 NCBI chr 1:164,012,585...164,026,967
Ensembl chr 1:164,012,592...164,026,933
JBrowse link
G Tmsb4x thymosin beta 4, X-linked multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of TMSB4X mRNA CTD PMID:32812032 NCBI chr  X:27,144,677...27,146,667
Ensembl chr  X:27,128,610...27,146,667
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
[Irinotecan co-treated with Ciprofloxacin] promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ciprofloxacin inhibits the reaction [Irinotecan promotes the reaction [Mitogens results in increased expression of TNF protein]]; Irinotecan inhibits the reaction [Mitogens results in increased expression of TNF protein]; Irinotecan promotes the reaction [Mitogens results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of TNF protein]
Irinotecan results in increased expression of TNF mRNA; Irinotecan results in increased expression of TNF protein
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [Irinotecan results in increased expression of TNF protein]]; carvacrol inhibits the reaction [Irinotecan results in increased expression of TNF protein]
CTD PMID:16815871 PMID:18182997 PMID:18535404 PMID:19401694 PMID:26431797 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO Irinotecan metabolite results in decreased expression of TNFAIP6 mRNA; Irinotecan results in decreased expression of TNFAIP6 mRNA CTD PMID:15956246 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression EXP Irinotecan results in increased expression of TNFRSF12A mRNA CTD PMID:20097248 NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 affects expression EXP Irinotecan affects the expression of TNFRSF14 mRNA CTD PMID:20097248 NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Irinotecan results in increased expression of TNFRSF1A mRNA CTD PMID:20097248 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases activity
ISO CFLAR protein alternative form inhibits the reaction [Irinotecan results in increased activity of TNFSF10 protein] CTD PMID:16373718 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tob1 transducer of ErbB-2.1 increases expression ISO Irinotecan metabolite results in increased expression of TOB1 mRNA; Irinotecan results in increased expression of TOB1 mRNA CTD PMID:15956246 NCBI chr10:79,163,093...79,165,131
Ensembl chr10:79,160,154...79,165,215
JBrowse link
G Tob2 transducer of ERBB2, 2 increases expression ISO Irinotecan metabolite results in increased expression of TOB2 mRNA; Irinotecan results in increased expression of TOB2 mRNA CTD PMID:15956246 NCBI chr 7:113,362,703...113,371,423
Ensembl chr 7:113,361,148...113,372,688
JBrowse link
G Top1 DNA topoisomerase I decreases activity
affects response to substance
affects binding
ISO Irinotecan results in decreased activity of TOP1 protein
TOP1 protein affects the susceptibility to Irinotecan
Irinotecan binds to TOP1 protein
CTD PMID:11914913 PMID:15041737 PMID:15655543 PMID:18509181 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha increases response to substance
decreases expression
ISO TOP2A mRNA results in increased susceptibility to Irinotecan
Irinotecan metabolite results in decreased expression of TOP2A mRNA; Irinotecan results in decreased expression of TOP2A mRNA
CTD PMID:15239142 PMID:15956246 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase decreases expression ISO Irinotecan metabolite results in decreased expression of TOPORS mRNA; Irinotecan results in decreased expression of TOPORS mRNA CTD PMID:15956246 NCBI chr 5:55,388,033...55,399,937
Ensembl chr 5:55,387,632...55,399,937
JBrowse link
G Tp53 tumor protein p53 increases expression
affects response to substance
increases phosphorylation
multiple interactions
increases response to substance
ISO Irinotecan results in increased expression of TP53 mRNA; Irinotecan results in increased expression of TP53 protein
TP53 protein affects the susceptibility to Irinotecan
Irinotecan results in increased phosphorylation of TP53 protein
[Irinotecan co-treated with Bortezomib] results in increased ubiquitination of TP53 protein; Irinotecan results in increased phosphorylation of and results in increased activity of TP53 protein; Irinotecan results in increased phosphorylation of and results in increased expression of TP53 protein; TP53 protein affects the susceptibility to [Irinotecan co-treated with Bortezomib]; TP53 protein inhibits the reaction [Irinotecan results in increased phosphorylation of STAT1 protein]
TP53 results in increased susceptibility to Irinotecan
CTD PMID:16204068 PMID:16373703 PMID:16963839 PMID:22510560 PMID:22898888 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Irinotecan analog results in increased expression of TP53INP1 mRNA CTD PMID:18927307 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
JBrowse link
G Tpmt thiopurine S-methyltransferase increases expression
multiple interactions
ISO Irinotecan analog results in increased expression of TPMT mRNA
TPMT protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
CTD PMID:18927307 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709
JBrowse link
G Tppp tubulin polymerization promoting protein increases expression ISO Irinotecan analog results in increased expression of TPPP mRNA CTD PMID:18927307 NCBI chr 1:29,257,111...29,281,134
Ensembl chr 1:29,261,255...29,281,134
JBrowse link
G Tpx2 TPX2, microtubule nucleation factor decreases expression ISO Irinotecan metabolite results in decreased expression of TPX2 mRNA; Irinotecan results in decreased expression of TPX2 mRNA CTD PMID:15956246 NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO Irinotecan metabolite results in increased expression of TRADD mRNA; Irinotecan results in increased expression of TRADD mRNA CTD PMID:15956246 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Traf1 TNF receptor-associated factor 1 decreases expression
increases expression
ISO Irinotecan metabolite results in decreased expression of TRAF1 mRNA; Irinotecan results in decreased expression of TRAF1 mRNA
Irinotecan metabolite results in increased expression of TRAF1 mRNA; Irinotecan results in increased expression of TRAF1 mRNA
CTD PMID:15956246 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 decreases expression ISO Irinotecan metabolite results in decreased expression of TRDMT1 mRNA; Irinotecan results in decreased expression of TRDMT1 mRNA CTD PMID:15956246 NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439
JBrowse link
G Trib1 tribbles pseudokinase 1 increases expression ISO Irinotecan analog results in increased expression of TRIB1 mRNA CTD PMID:18927307 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
JBrowse link
G Trib2 tribbles pseudokinase 2 affects expression ISO Irinotecan analog affects the expression of TRIB2 mRNA CTD PMID:18927307 NCBI chr 6:38,545,971...38,570,349
Ensembl chr 6:38,545,975...38,569,370
JBrowse link
G Trim9 tripartite motif-containing 9 increases expression ISO Irinotecan analog results in increased expression of TRIM9 mRNA CTD PMID:18927307 NCBI chr 6:88,756,824...88,856,588
Ensembl chr 6:88,757,303...88,856,542
JBrowse link
G Trmt13 tRNA methyltransferase 13 homolog decreases expression ISO Irinotecan analog results in decreased expression of TRMT13 mRNA CTD PMID:18927307 NCBI chr 2:204,533,630...204,547,711
Ensembl chr 2:204,533,632...204,546,843
JBrowse link
G Tsen2 tRNA splicing endonuclease subunit 2 decreases expression ISO Irinotecan results in decreased expression of TSEN2 mRNA CTD PMID:20185912 NCBI chr 4:148,602,805...148,638,219
Ensembl chr 4:148,602,863...148,638,215
JBrowse link
G Tspan4 tetraspanin 4 increases expression EXP Irinotecan results in increased expression of TSPAN4 mRNA CTD PMID:20097248 NCBI chr 1:196,571,307...196,593,842
Ensembl chr 1:196,572,228...196,617,448
JBrowse link
G Tspan8 tetraspanin 8 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of TSPAN8 mRNA CTD PMID:16391804 NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356
JBrowse link
G Ttk Ttk protein kinase decreases expression ISO Irinotecan metabolite results in decreased expression of TTK mRNA; Irinotecan results in decreased expression of TTK mRNA CTD PMID:15956246 NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Irinotecan results in increased expression of TXNIP mRNA CTD PMID:20185912 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Txnrd1 thioredoxin reductase 1 affects expression EXP Irinotecan affects the expression of TXNRD1 mRNA CTD PMID:20097248 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO TYMP mRNA affects the susceptibility to [Irinotecan co-treated with Fluorouracil co-treated with Leucovorin] CTD PMID:17454858 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO TYMS mRNA affects the susceptibility to [Irinotecan co-treated with Fluorouracil co-treated with Leucovorin] CTD PMID:17454858 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of TYROBP mRNA CTD PMID:32812032 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848
JBrowse link
G Ubd ubiquitin D affects expression EXP Irinotecan affects the expression of UBD mRNA CTD PMID:20097248 NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO
EXP
Irinotecan metabolite results in decreased expression of UBE2C mRNA; Irinotecan results in decreased expression of UBE2C mRNA CTD PMID:15956246 PMID:20097248 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Ube2e3 ubiquitin-conjugating enzyme E2E 3 decreases expression ISO Irinotecan analog results in decreased expression of UBE2E3 mRNA CTD PMID:18927307 NCBI chr 3:63,786,976...63,851,400
Ensembl chr 3:63,786,650...63,843,237
JBrowse link
G Ube2j2 ubiquitin-conjugating enzyme E2, J2 decreases expression ISO Irinotecan analog results in decreased expression of UBE2J2 mRNA CTD PMID:18927307 NCBI chr 5:166,533,374...166,547,811
Ensembl chr 5:166,533,418...166,547,804
JBrowse link
G Ube2l6 ubiquitin-conjugating enzyme E2L 6 affects expression EXP Irinotecan affects the expression of UBE2L6 mRNA CTD PMID:20097248 NCBI chr 3:69,873,025...69,888,042
Ensembl chr 3:69,873,424...69,888,048
JBrowse link
G Uchl5 ubiquitin C-terminal hydrolase L5 decreases expression ISO Irinotecan metabolite results in decreased expression of UCHL5 mRNA; Irinotecan results in decreased expression of UCHL5 mRNA CTD PMID:15956246 NCBI chr13:55,520,722...55,556,503
Ensembl chr13:55,520,729...55,556,502
JBrowse link
G Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 decreases expression ISO Irinotecan analog results in decreased expression of UGGT2 mRNA CTD PMID:18927307 NCBI chr15:96,074,557...96,239,365
Ensembl chr15:96,074,564...96,237,806
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects response to substance
decreases glucuronidation
increases glucuronidation
increases metabolic processing
affects metabolic processing
multiple interactions
ISO
EXP
UGT1A1 gene polymorphism affects the susceptibility to Irinotecan; UGT1A1 promoter polymorphism affects the susceptibility to Irinotecan; UGT1A1 protein affects the susceptibility to Irinotecan
UGT1A1 gene mutant form results in decreased glucuronidation of Irinotecan; UGT1A1 protein polymorphism results in decreased glucuronidation of Irinotecan
UGT1A1 protein results in increased glucuronidation of Irinotecan
UGT1A1 protein results in increased metabolism of Irinotecan
UGT1A1 protein affects the metabolism of Irinotecan
[Ketoconazole results in decreased activity of UGT1A1 protein] which results in decreased metabolism of Irinotecan; UGT1A1 gene polymorphism affects the susceptibility to [Fluorouracil co-treated with Irinotecan]; UGT1A1 protein results in increased glucuronidation of and results in decreased activity of Irinotecan
CTD PMID:12960109 PMID:15517893 PMID:15523087 PMID:15655543 PMID:15716465 More... NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Irinotecan CTD PMID:15716465 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Irinotecan; UGT1A8 protein results in increased glucuronidation of Irinotecan CTD PMID:15833930 NCBI chr 9:88,739,577...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO
EXP
UGT1A9 protein results in increased glucuronidation of Irinotecan CTD PMID:15833930 PMID:17898154 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ulk4 unc-51 like kinase 4 decreases expression ISO Irinotecan analog results in decreased expression of ULK4 mRNA CTD PMID:18927307 NCBI chr 8:120,670,879...120,966,026
Ensembl chr 8:120,670,866...120,966,924
JBrowse link
G Uso1 USO1 vesicle transport factor decreases expression ISO Irinotecan analog results in decreased expression of USO1 mRNA CTD PMID:18927307 NCBI chr14:15,866,638...15,932,185
Ensembl chr14:15,866,638...15,932,171
JBrowse link
G Usp24 ubiquitin specific peptidase 24 decreases expression ISO Irinotecan analog results in decreased expression of USP24 mRNA CTD PMID:18927307 NCBI chr 5:121,080,687...121,210,321
Ensembl chr 5:121,080,470...121,210,311
JBrowse link
G Utp3 UTP3, small subunit processome component multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of UTP3 mRNA CTD PMID:16391804 NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396
JBrowse link
G Vldlr very low density lipoprotein receptor affects expression EXP Irinotecan affects the expression of VLDLR mRNA CTD PMID:20097248 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
JBrowse link
G Vps13b vacuolar protein sorting 13 homolog B decreases expression EXP Irinotecan results in decreased expression of VPS13B mRNA CTD PMID:20097248 NCBI chr 7:66,557,862...67,128,429
Ensembl chr 7:66,558,471...67,128,429
JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A decreases expression ISO Irinotecan analog results in decreased expression of VPS4A mRNA CTD PMID:18927307 NCBI chr19:34,934,999...34,948,267
Ensembl chr19:34,934,961...34,948,887
JBrowse link
G Vti1a vesicle transport through interaction with t-SNAREs 1A decreases expression ISO Irinotecan analog results in decreased expression of VTI1A mRNA CTD PMID:18927307 NCBI chr 1:254,356,343...254,661,854
Ensembl chr 1:254,356,429...254,661,852
JBrowse link
G Wapl WAPL cohesin release factor decreases expression ISO Irinotecan analog results in decreased expression of WAPL mRNA CTD PMID:18927307 NCBI chr16:10,005,520...10,075,270
Ensembl chr16:10,004,941...10,073,510
JBrowse link
G Wasl WASP like actin nucleation promoting factor decreases expression ISO Irinotecan analog results in decreased expression of WASL mRNA CTD PMID:18927307 NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:53,083,536...53,132,022
JBrowse link
G Wdfy1 WD repeat and FYVE domain containing 1 affects expression EXP Irinotecan affects the expression of WDFY1 mRNA CTD PMID:20097248 NCBI chr 9:81,034,852...81,092,823
Ensembl chr 9:81,034,849...81,092,775
JBrowse link
G Wnt16 Wnt family member 16 increases expression ISO Irinotecan analog results in increased expression of WNT16 mRNA CTD PMID:18927307 NCBI chr 4:50,820,968...50,831,380
Ensembl chr 4:50,820,968...50,831,380
JBrowse link
G Wsb1 WD repeat and SOCS box-containing 1 increases expression ISO Irinotecan analog results in increased expression of WSB1 mRNA CTD PMID:18927307 NCBI chr10:64,202,761...64,219,039
Ensembl chr10:64,202,763...64,219,019
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [Irinotecan co-treated with alvocidib] results in increased cleavage of XIAP protein CTD PMID:11751522 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor decreases expression ISO Irinotecan results in decreased expression of XPA protein CTD PMID:11593056 NCBI chr 5:60,431,673...60,476,438
Ensembl chr 5:60,431,673...60,475,726
JBrowse link
G Xpo7 exportin 7 decreases expression ISO Irinotecan analog results in decreased expression of XPO7 mRNA CTD PMID:18927307 NCBI chr15:45,742,053...45,828,050
Ensembl chr15:45,742,053...45,828,050
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases expression ISO Irinotecan metabolite results in decreased expression of XRCC4 mRNA; Irinotecan results in decreased expression of XRCC4 mRNA CTD PMID:15956246 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression ISO Irinotecan analog results in decreased expression of XRCC5 mRNA CTD PMID:18927307 NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018
JBrowse link
G Yaf2 YY1 associated factor 2 decreases expression ISO Irinotecan analog results in decreased expression of YAF2 mRNA CTD PMID:18927307 NCBI chr 7:124,444,152...124,499,688
Ensembl chr 7:124,444,152...124,499,928
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase decreases expression ISO Irinotecan metabolite results in decreased expression of YES1 mRNA; Irinotecan results in decreased expression of YES1 mRNA CTD PMID:15956246 NCBI chr 9:113,200,256...113,275,942
Ensembl chr 9:113,200,256...113,299,837
JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 decreases expression ISO Irinotecan analog results in decreased expression of ZBTB20 mRNA CTD PMID:18927307 NCBI chr11:57,052,129...57,823,679
Ensembl chr11:57,072,880...57,510,210
JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 decreases expression ISO Irinotecan analog results in decreased expression of ZC3HAV1 mRNA CTD P