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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-Desmethyltamoxifen
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Accession:CHEBI:80554 term browser browse the term
Definition:A stilbenoid that has formula C25H27NO.
Synonyms:related_synonym: Formula=C25H27NO;   InChI=1S/C25H27NO/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2/h4-17,26H,3,18-19H2,1-2H3/b25-24-;   InChIKey=NYDCDZSEEAUOHN-IZHYLOQSSA-N;   SMILES=CC\\C(c1ccccc1)=C(/c1ccccc1)c1ccc(OCCNC)cc1
 xref: CAS:31750-48-8;   HMDB:HMDB0013866;   KEGG:C16546
 xref_mesh: MESH:C028787


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N-Desmethyltamoxifen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
ISO CYP1A2 protein results in increased metabolism of N-desmethyltamoxifen
[CYP1A2 protein results in increased metabolism of N-desmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene
CTD PMID:29285606 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO N-desmethyltamoxifen results in decreased activity of CYP1B1 protein CTD PMID:12419016 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases metabolic processing
increases abundance
ISO [CYP2D6 protein results in increased metabolism of N-desmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of N-desmethyltamoxifen; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased glucuronidation of N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased hydroxylation of N-desmethyltamoxifen
CYP2D6 protein results in increased abundance of N-desmethyltamoxifen
CTD PMID:14652237 PMID:29285606 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity
multiple interactions
increases metabolic processing
ISO N-desmethyltamoxifen results in decreased activity of CYP3A4 protein
[CYP3A4 protein results in increased metabolism of N-desmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene; [Troleandomycin results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of N-desmethyltamoxifen
CTD PMID:12419016 PMID:14652237 PMID:29285606 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases activity
multiple interactions
increases metabolic processing
ISO N-desmethyltamoxifen results in decreased activity of CYP3A5 protein
[CYP3A5 protein results in increased metabolism of N-desmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene
CTD PMID:12419016 PMID:29285606 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 4-hydroxy-N-desmethyltamoxifen inhibits the reaction [[Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 protein]; [Tamoxifen co-treated with N-desmethyltamoxifen co-treated with afimoxifene] results in increased stability of ESR1 protein CTD PMID:19244106 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO [SULT1A1 protein results in increased metabolism of Tamoxifen] which results in increased abundance of N-desmethyltamoxifen CTD PMID:30120701 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      atom 19873
        nonmetal atom 19751
          carbon atom 19657
            organic molecular entity 19657
              olefinic compound 14850
                stilbenoid 5644
                  N-Desmethyltamoxifen 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic aromatic compound 19220
                                  stilbenoid 5644
                                    N-Desmethyltamoxifen 7
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