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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N'-Nitrosonornicotine
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Accession:CHEBI:80502 term browser browse the term
Definition:A pyrrolidine that has formula C9H11N3O.
Synonyms:related_synonym: Formula=C9H11N3O;   InChI=1S/C9H11N3O/c13-11-12-6-2-4-9(12)8-3-1-5-10-7-8/h1,3,5,7,9H,2,4,6H2;   InChIKey=XKABJYQDMJTNGQ-UHFFFAOYSA-N;   NNN;   SMILES=O=NN1CCCC1c1cccnc1
 xref: CAS:16543-55-8;   HMDB:HMDB0041940;   KEGG:C16452
 xref_mesh: MESH:C008655


show annotations for term's descendants           Sort by:
N'-Nitrosonornicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 ISO N'-nitrosonornicotine results in increased expression of BCL2 mRNA
Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of BCL2 mRNA]		 CTD PMID:16582591 PMID:16835749 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit affects binding ISO N'-nitrosonornicotine binds to CHRNA3 protein CTD PMID:16835749 PMID:18385738 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit affects binding ISO N'-nitrosonornicotine binds to CHRNA5 protein CTD PMID:18385738 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit affects binding ISO N'-nitrosonornicotine binds to CHRNB4 protein CTD PMID:18385738 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO CYP1A1 protein affects the metabolism of and results in increased activity of N'-nitrosonornicotine CTD PMID:11774366 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases metabolic processing
increases hydroxylation
multiple interactions		 ISO CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine
CYP2A13 protein results in increased hydroxylation of N'-nitrosonornicotine
[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone; [CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-4-(3-pyridyl)butanoic acid; [CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-oxo-4-(3-pyridinebutanal); N'-nitrosoanabasine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone]; N'-nitrosoanatabine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone]; Nicotine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone]		 CTD PMID:17922361 PMID:27567546 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP2B6 protein co-treated with cupric chloride co-treated with NADP] results in increased metabolism of N'-nitrosonornicotine CTD PMID:32672941 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Gata3 GATA binding protein 3 multiple interactions
increases activity
increases expression		 ISO Bungarotoxins inhibits the reaction [N'-nitrosonornicotine results in increased activity of GATA3 protein]; Bungarotoxins inhibits the reaction [N'-nitrosonornicotine results in increased expression of GATA3 mRNA]; Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased activity of GATA3 protein]; Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of GATA3 mRNA] CTD PMID:16582591 PMID:16835749 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression		 ISO Bungarotoxins inhibits the reaction [N'-nitrosonornicotine results in increased expression of NFKB1 mRNA]; Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of NFKB1 mRNA] CTD PMID:16582591 PMID:16835749 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression		 ISO Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of PCNA mRNA] CTD PMID:16582591 PMID:16835749 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pla2g2a phospholipase A2 group IIA increases expression EXP N'-nitrosonornicotine results in increased expression of PLA2G2A mRNA CTD PMID:24835565 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Pla2g4a phospholipase A2 group IVA increases expression EXP N'-nitrosonornicotine results in increased expression of PLA2G4A mRNA CTD PMID:24835565 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
increases expression
increases activity		 ISO Bungarotoxins inhibits the reaction [N'-nitrosonornicotine results in increased activity of STAT1 protein]; Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased activity of STAT1 protein]; Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of STAT1 mRNA] CTD PMID:16582591 PMID:16835749 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of N'-nitrosonornicotine CTD PMID:18238858 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      atom 19809
        nonmetal atom 19747
          nitrogen atom 18962
            nitrogen molecular entity 18934
              organonitrogen compound 18783
                organonitrogen heterocyclic compound 18154
                  pyridines 11520
                    N'-Nitrosonornicotine 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                organic heterocyclic compound 18862
                                  organic heteromonocyclic compound 17772
                                    pyridines 11520
                                      N'-Nitrosonornicotine 14
paths to the root