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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N'-Nitrosonornicotine
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Accession:CHEBI:80502 term browser browse the term
Definition:A pyrrolidine that has formula C9H11N3O.
Synonyms:related_synonym: Formula=C9H11N3O;   InChI=1S/C9H11N3O/c13-11-12-6-2-4-9(12)8-3-1-5-10-7-8/h1,3,5,7,9H,2,4,6H2;   InChIKey=XKABJYQDMJTNGQ-UHFFFAOYSA-N;   NNN;   SMILES=O=NN1CCCC1c1cccnc1
 xref: CAS:16543-55-8;   HMDB:HMDB0041940;   KEGG:C16452
 xref_mesh: MESH:C008655


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N'-Nitrosonornicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
ISO N'-nitrosonornicotine results in increased expression of BCL2 mRNA
Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of BCL2 mRNA]
CTD PMID:16582591 PMID:16835749 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit affects binding ISO N'-nitrosonornicotine binds to CHRNA3 protein CTD PMID:16835749 PMID:18385738 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit affects binding ISO N'-nitrosonornicotine binds to CHRNA5 protein CTD PMID:18385738 NCBI chr 8:59,561,817...59,590,172
Ensembl chr 8:59,561,721...59,590,172
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit affects binding ISO N'-nitrosonornicotine binds to CHRNB4 protein CTD PMID:18385738 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO CYP1A1 protein affects the metabolism of and results in increased activity of N'-nitrosonornicotine CTD PMID:11774366 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases metabolic processing
multiple interactions
increases hydroxylation
ISO CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine
[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone; [CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-4-(3-pyridyl)butanoic acid; [CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-oxo-4-(3-pyridinebutanal); N'-nitrosoanabasine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone]; N'-nitrosoanatabine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone]; Nicotine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone]
CYP2A13 protein results in increased hydroxylation of N'-nitrosonornicotine
CTD PMID:17922361 PMID:27567546 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP2B6 protein co-treated with cupric chloride co-treated with NADP] results in increased metabolism of N'-nitrosonornicotine CTD PMID:32672941 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions
increases activity
increases expression
ISO Bungarotoxins inhibits the reaction [N'-nitrosonornicotine results in increased activity of GATA3 protein]; Bungarotoxins inhibits the reaction [N'-nitrosonornicotine results in increased expression of GATA3 mRNA]; Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased activity of GATA3 protein]; Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of GATA3 mRNA] CTD PMID:16582591 PMID:16835749 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression
ISO Bungarotoxins inhibits the reaction [N'-nitrosonornicotine results in increased expression of NFKB1 mRNA]; Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of NFKB1 mRNA] CTD PMID:16582591 PMID:16835749 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
ISO Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of PCNA mRNA] CTD PMID:16582591 PMID:16835749 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pla2g2a phospholipase A2 group IIA increases expression EXP N'-nitrosonornicotine results in increased expression of PLA2G2A mRNA CTD PMID:24835565 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Pla2g4a phospholipase A2 group IVA increases expression EXP N'-nitrosonornicotine results in increased expression of PLA2G4A mRNA CTD PMID:24835565 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
increases activity
increases expression
ISO Bungarotoxins inhibits the reaction [N'-nitrosonornicotine results in increased activity of STAT1 protein]; Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased activity of STAT1 protein]; Mecamylamine inhibits the reaction [N'-nitrosonornicotine results in increased expression of STAT1 mRNA] CTD PMID:16582591 PMID:16835749 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of N'-nitrosonornicotine CTD PMID:18238858 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    chemical entity 19767
      atom 19766
        nonmetal atom 19645
          nitrogen atom 18578
            nitrogen molecular entity 18578
              organonitrogen compound 18368
                organonitrogen heterocyclic compound 17523
                  pyridines 8438
                    N'-Nitrosonornicotine 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    p-block element atom 19657
                      carbon group element atom 19573
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19496
                              organic cyclic compound 19322
                                organic heterocyclic compound 18510
                                  organic heteromonocyclic compound 16989
                                    pyridines 8438
                                      N'-Nitrosonornicotine 14
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