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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzidine
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Accession:CHEBI:80495 term browser browse the term
Definition:A member of the class of biphenyls that is 1,1'-biphenyl in which the hydrogen at the para-position of each phenyl group has been replaced by an amino group.
Synonyms:exact_synonym: biphenyl-4,4'-diamine
 related_synonym: (1,1'-biphenyl)-4,4'-diamine;   4,4'-bianiline;   4,4'-biphenyldiamine;   4,4'-biphenylenediamine;   4,4'-diamino-1,1'-biphenyl;   4,4'-diaminobiphenyl;   4,4'-diaminodiphenyl;   4,4'-diphenylenediamine;   C.I. azoic diazo component 112;   Formula=C12H12N2;   InChI=1S/C12H12N2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8H,13-14H2;   InChIKey=HFACYLZERDEVSX-UHFFFAOYSA-N;   SMILES=C1=C(C=CC(=C1)C=2C=CC(=CC2)N)N;   p,p'-bianiline;   p,p'-diaminodiphenyl;   p-diaminodiphenyl
 xref: CAS:92-87-5;   HMDB:HMDB0041835;   KEGG:C16444
 xref_mesh: MESH:C029876
 xref: PMID:15317128;   PMID:21089809;   PMID:23766236;   PMID:25151432;   PMID:25281283;   PMID:25757908;   PMID:7341968;   Reaxys:742770;   Wikipedia:Benzidine



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benzidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO benzidine results in increased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Bik BCL2-interacting killer increases expression ISO benzidine results in increased expression of BIK mRNA CTD PMID:26198647 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO benzidine results in increased expression of GCLC mRNA CTD PMID:26198647 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO benzidine results in increased expression of GCLM mRNA CTD PMID:26198647 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Lpo lactoperoxidase increases metabolic processing ISO LPO protein results in increased metabolism of benzidine CTD PMID:15606142 NCBI chr10:72,606,944...72,626,535
Ensembl chr10:72,606,944...72,626,535
JBrowse link
G Mpo myeloperoxidase affects metabolic processing ISO MPO protein affects the metabolism of benzidine CTD PMID:9288889 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nat1 N-acetyltransferase 1 increases activity ISO NAT1 protein results in increased activity of benzidine CTD PMID:15450435 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nat2 N-acetyltransferase 2 affects response to substance ISO NAT2 gene polymorphism affects the susceptibility to benzidine CTD PMID:16003747 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of benzidine CTD PMID:11159734 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing ISO PTGS2 protein results in increased metabolism of benzidine CTD PMID:11159734 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO benzidine results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO benzidine results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO benzidine results in increased expression of SRXN1 mRNA CTD PMID:26198647 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Tp53 tumor protein p53 increases expression ISO benzidine results in increased expression of TP53 protein mutant form CTD PMID:15748509 PMID:17690521 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases metabolic processing ISO UGT2B7 protein results in increased metabolism of benzidine CTD PMID:15615884 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        aetiopathogenetic role 19264
          carcinogenic agent 18536
            benzidine 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19744
                        hydrogen molecular entity 19736
                          hydrides 19102
                            inorganic hydride 17893
                              pnictogen hydride 17876
                                nitrogen hydride 17766
                                  azane 17518
                                    ammonia 17517
                                      organic amino compound 17517
                                        aromatic amine 14924
                                          anilines 13985
                                            substituted aniline 13663
                                              benzidine 15
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