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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aliphatic nitrile
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Accession:CHEBI:80291 term browser browse the term
Definition:Any nitrile derived from an aliphatic compound.
Synonyms:related_synonym: Formula=CNR;   SMILES=[*]C#N;   an aliphatic nitrile
 xref: KEGG:C16072


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2-bromo-2-(bromomethyl)pentanedinitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 increases expression ISO 1,2-dibromo-2,4-dicyanobutane results in increased expression of ATF3 mRNA CTD PMID:23999411 PMID:27965148 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO 1,2-dibromo-2,4-dicyanobutane results in increased expression of DNAJB4 mRNA CTD PMID:23999411 PMID:27965148 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO 1,2-dibromo-2,4-dicyanobutane results in increased expression of GCLM mRNA CTD PMID:23999411 PMID:27965148 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 1,2-dibromo-2,4-dicyanobutane results in increased expression of HMOX1 mRNA CTD PMID:23445166 PMID:26244607 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il18 interleukin 18 increases expression ISO 1,2-dibromo-2,4-dicyanobutane results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta increases expression ISO 1,2-dibromo-2,4-dicyanobutane results in increased expression of IL1B mRNA CTD PMID:33715048 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO 1,2-dibromo-2,4-dicyanobutane results in increased expression of HSPA6 mRNA CTD PMID:23999411 NCBI chr13:83,271,340...83,275,267 JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 1,2-dibromo-2,4-dicyanobutane results in increased expression of TXNRD1 mRNA CTD PMID:23445166 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
3-cyanoalanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions ISO 3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein] CTD PMID:29129814 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO 3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein] CTD PMID:29129814 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Usp5 ubiquitin specific peptidase 5 multiple interactions ISO 3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of USP5 protein] CTD PMID:29129814 NCBI chr 4:157,619,643...157,634,711
Ensembl chr 4:157,619,643...157,634,711
JBrowse link
acetonitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 multiple interactions EXP acetonitrile inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19858067 NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP acetonitrile inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19858067 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP acetonitrile inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin] CTD PMID:19858067 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 multiple interactions EXP acetonitrile inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] CTD PMID:19858067 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO
EXP
acetonitrile inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]
acetonitrile inhibits the reaction [CYP2E1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
CTD PMID:9143349 PMID:19858067 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP acetonitrile inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19858067 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Nefh neurofilament heavy chain affects expression EXP acetonitrile affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 increases expression ISO acetonitrile results in increased expression of SLC9A3R1 protein CTD PMID:22434383 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions
decreases activity
ISO acetonitrile inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; acetonitrile inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]
acetonitrile results in decreased activity of SULT1A1 protein
CTD PMID:14570759 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO acetonitrile promotes the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene] CTD PMID:14570759 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
acrylonitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex2 apurinic/apyrimidinic endodeoxyribonuclease 2 increases expression
multiple interactions
EXP Acrylonitrile results in increased expression of APEX2 mRNA
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA]
CTD PMID:26332274 NCBI chr  X:19,425,684...19,508,459
Ensembl chr  X:19,487,419...19,508,439
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Acrylonitrile results in increased expression of BAX protein
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of BAX protein]
CTD PMID:16173056 PMID:20981856 PMID:33132245 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Acrylonitrile results in decreased expression of BCL2 protein CTD PMID:16173056 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Acrylonitrile results in decreased expression of BCL2L1 protein CTD PMID:33132245 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp12 caspase 12 increases expression ISO Acrylonitrile results in increased expression of CASP12 protein CTD PMID:33132245 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Acrylonitrile results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased activity of CASP3 protein]
CTD PMID:20981856 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP Acrylonitrile results in decreased activity of CAT protein
Curcumin inhibits the reaction [Acrylonitrile results in decreased activity of CAT protein]
CTD PMID:19913070 PMID:20127315 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbs cystathionine beta synthase decreases expression EXP Acrylonitrile results in decreased expression of CBS protein CTD PMID:33486070 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
increases expression
multiple interactions
ISO
EXP
Acrylonitrile results in decreased expression of CCL2 mRNA
Acrylonitrile results in increased expression of CCL2 mRNA
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]
CTD PMID:16173056 PMID:26332274 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
increases expression
EXP
ISO
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCND1 mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND1 mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of CCND1 mRNA]
Acrylonitrile results in decreased expression of CCND1 protein
Acrylonitrile results in increased expression of CCND1 protein
CTD PMID:26332274 PMID:30236600 PMID:33132245 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA] CTD PMID:26332274 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccne1 cyclin E1 increases expression
decreases expression
ISO Acrylonitrile results in increased expression of CCNE1 protein
Acrylonitrile results in decreased expression of CCNE1 protein
CTD PMID:30236600 PMID:33132245 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO Acrylonitrile results in decreased expression of CDH1 protein CTD PMID:30236600 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 increases expression ISO Acrylonitrile results in increased expression of CDH2 protein CTD PMID:30236600 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
decreases expression
EXP
ISO
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CDKN1A mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CDKN1A mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of CDKN1A mRNA]
Acrylonitrile results in increased expression of CDKN1A protein
Acrylonitrile results in decreased expression of CDKN1A protein
CTD PMID:10451498 PMID:26332274 PMID:30236600 PMID:33132245 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
increases expression
ISO Acrylonitrile results in decreased expression of CDKN1B protein
Acrylonitrile results in increased expression of CDKN1B protein
CTD PMID:30236600 PMID:33132245 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cth cystathionine gamma-lyase decreases expression EXP Acrylonitrile results in decreased expression of CTH protein CTD PMID:33486070 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Acrylonitrile results in decreased expression of CXCR4 mRNA CTD PMID:16173056 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects response to substance
increases metabolic processing
multiple interactions
increases expression
increases oxidation
EXP
ISO
CYP2E1 protein affects the susceptibility to Acrylonitrile
CYP2E1 protein results in increased metabolism of Acrylonitrile
[CYP2E1 protein results in increased metabolism of Acrylonitrile] which results in increased chemical synthesis of 2-cyanoethylene oxide; CYP2E1 gene mutant form inhibits the reaction [Acrylonitrile results in increased mutagenesis of HPRT gene]
Acrylonitrile results in increased expression of CYP2E1 mRNA
Acetylcysteine promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]; Acrylonitrile inhibits the reaction [[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Benzene]; alpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]; Plant Extracts promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]
CYP2E1 protein results in increased oxidation of Acrylonitrile
CTD PMID:1664256 PMID:9010585 PMID:20127315 PMID:26332274 PMID:32529832 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Acrylonitrile results in increased expression of DDIT3 protein CTD PMID:33132245 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression ISO Acrylonitrile results in increased expression of EIF2S1 protein modified form CTD PMID:33132245 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Acrylonitrile results in decreased expression of FOS protein CTD PMID:16173056 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Acrylonitrile results in increased expression of HMOX1 protein CTD PMID:14644359 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions
increases mutagenesis
ISO
EXP
CYP2E1 gene mutant form inhibits the reaction [Acrylonitrile results in increased mutagenesis of HPRT gene] CTD PMID:32529823 PMID:32529832 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of IL1B mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of IL1B mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of IL1B mRNA] CTD PMID:26332274 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Acrylonitrile results in decreased expression of JUN protein CTD PMID:16173056 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Acrylonitrile results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]; rottlerin inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]
CTD PMID:17080406 PMID:30236600 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein]; rottlerin inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein] CTD PMID:17080406 PMID:30236600 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mpst mercaptopyruvate sulfurtransferase decreases expression EXP Acrylonitrile results in decreased expression of MPST protein CTD PMID:33486070 NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
ISO Acrylonitrile results in increased activity of NQO1 protein
Acrylonitrile results in increased expression of NQO1 mRNA
CTD PMID:9029048 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ocln occludin decreases expression ISO Acrylonitrile results in decreased expression of OCLN protein CTD PMID:30236600 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Acrylonitrile results in increased cleavage of PARP1 protein
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased cleavage of PARP1 protein]
CTD PMID:20981856 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Plcb1 phospholipase C beta 1 affects localization EXP Acrylonitrile affects the localization of PLCB1 protein CTD PMID:12850505 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Plcd1 phospholipase C, delta 1 multiple interactions EXP Acrylonitrile results in increased expression of and affects the localization of PLCD1 protein CTD PMID:12850505 NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases expression EXP Acrylonitrile results in increased expression of PLCG1 protein CTD PMID:12850505 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G S100a8 S100 calcium binding protein A8 decreases expression ISO Acrylonitrile results in decreased expression of S100A8 mRNA CTD PMID:16173056 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression ISO Acrylonitrile results in increased expression of SNAI2 protein CTD PMID:30236600 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Acrylonitrile inhibits the reaction [3,3'-iminodipropionitrile results in increased expression of TH protein] CTD PMID:19244277 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of TNF mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of TNF mRNA] CTD PMID:26332274 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Acrylonitrile results in increased expression of TP53 protein CTD PMID:33132245 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Xrcc6 X-ray repair cross complementing 6 multiple interactions
increases expression
EXP Acetylcysteine promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA]; alpha-Tocopherol promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA]; Plant Extracts promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA] CTD PMID:26332274 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762
JBrowse link
beta-aminopropionitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Aminopropionitrile results in decreased expression of BCL2 protein CTD PMID:24614111 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Eln elastin multiple interactions
decreases expression
EXP Aminopropionitrile results in increased expression of and results in increased degradation of ELN protein modified form
Aminopropionitrile results in decreased expression of ELN mRNA
CTD PMID:1680324 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Lox lysyl oxidase decreases activity
multiple interactions
EXP
ISO
Aminopropionitrile results in decreased activity of LOX protein
Aminopropionitrile inhibits the reaction [cupric chloride results in increased activity of LOX protein]
CTD PMID:16023247 PMID:19524603 PMID:22367676 PMID:25044713 NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases activity ISO Aminopropionitrile results in decreased activity of MMP14 protein CTD PMID:24014025 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Aminopropionitrile results in decreased expression of PCNA protein CTD PMID:24614111 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
borrelidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases response to substance ISO BCL2 protein results in decreased susceptibility to borrelidin CTD PMID:24155182 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO borrelidin results in increased activity of CASP3 protein
borrelidin results in increased cleavage of CASP3 protein
CTD PMID:14563161 PMID:26271225 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO borrelidin results in increased activity of CASP8 protein CTD PMID:14563161 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO borrelidin results in increased expression of DDIT3 protein CTD PMID:21678129 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO borrelidin results in increased phosphorylation of EIF2A protein CTD PMID:26271225 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 increases activity ISO borrelidin results in increased activity of EIF2AK4 protein CTD PMID:21678129 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases activity
multiple interactions
ISO borrelidin results in decreased activity of TARS1 protein
borrelidin analog binds to and affects the folding of TARS1 protein; borrelidin binds to and affects the folding of TARS1 protein; borrelidin binds to and results in decreased activity of TARS1 protein
CTD PMID:25489076 PMID:25824639 PMID:26271225 NCBI chr 2:60,368,251...60,387,733
Ensembl chr 2:60,367,796...60,387,717
JBrowse link
G Vegfa vascular endothelial growth factor A affects splicing
multiple interactions
ISO borrelidin affects the splicing of VEGFA mRNA; borrelidin analog affects the splicing of VEGFA mRNA
borrelidin analog inhibits the reaction [WBP4 protein affects the splicing of VEGFA mRNA]
CTD PMID:22822423 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Wbp4 WW domain binding protein 4 affects binding
multiple interactions
ISO borrelidin analog binds to WBP4 protein; borrelidin binds to WBP4 protein
borrelidin analog inhibits the reaction [WBP4 protein affects the splicing of VEGFA mRNA]
CTD PMID:22822423 NCBI chr15:54,862,700...54,890,668
Ensembl chr15:54,862,843...54,890,647
JBrowse link
carbonyl cyanide p-trifluoromethoxyphenylhydrazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP [Egtazic Acid co-treated with Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone] inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species] CTD PMID:18854758 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased phosphorylation of AKT1 protein CTD PMID:19901985 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [AQP9 protein results in increased uptake of Selenious Acid] CTD PMID:28798983 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of BAX mRNA CTD PMID:16039398 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of BCL2L1 mRNA CTD PMID:16039398 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 increases activity ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased activity of CASP3 protein CTD PMID:20683024 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of CASP8 mRNA CTD PMID:16039398 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of CAT mRNA CTD PMID:16039398 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnc cyclin C decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of CCNC mRNA CTD PMID:16039398 NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of CCND1 mRNA CTD PMID:16039398 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccng1 cyclin G1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of CCNG1 mRNA CTD PMID:16039398 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone promotes the reaction [CDKN1B protein binds to CDK4 protein] CTD PMID:19819288 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone promotes the reaction [CDKN1B protein binds to CDK4 protein]
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of CDKN1B protein
CTD PMID:19819288 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Comt catechol-O-methyltransferase decreases activity
multiple interactions
ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein
[Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate
CTD PMID:14975680 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Coq10a coenzyme Q10A decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of COQ10A protein CTD PMID:21308897 NCBI chr 7:792,089...798,392
Ensembl chr 7:792,089...800,161
JBrowse link
G Coq2 coenzyme Q2, polyprenyltransferase increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of COQ2 mRNA CTD PMID:21308897 NCBI chr14:8,941,429...8,961,418
Ensembl chr14:8,941,461...8,960,891
JBrowse link
G Coq3 coenzyme Q3 methyltransferase decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of COQ3 mRNA CTD PMID:21308897 NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:35,429,574...35,460,607
JBrowse link
G Coq4 coenzyme Q4 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of COQ4 mRNA CTD PMID:21308897 NCBI chr 3:13,060,054...13,070,502
Ensembl chr 3:13,060,455...13,068,799
JBrowse link
G Coq5 coenzyme Q5, methyltransferase increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of COQ5 mRNA CTD PMID:21308897 NCBI chr12:41,316,922...41,333,855
Ensembl chr12:41,316,748...41,333,848
JBrowse link
G Coq6 coenzyme Q6 monooxygenase increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of COQ6 mRNA CTD PMID:21308897 NCBI chr 6:104,007,814...104,019,888
Ensembl chr 6:104,007,872...104,024,657
JBrowse link
G Coq7 coenzyme Q7, hydroxylase increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of COQ7 mRNA CTD PMID:21308897 NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158
JBrowse link
G Coq8a coenzyme Q8A increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of COQ8A mRNA CTD PMID:21308897 NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
JBrowse link
G Coq9 coenzyme Q9 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of COQ9 mRNA CTD PMID:21308897 NCBI chr19:10,166,948...10,179,976
Ensembl chr19:10,166,951...10,179,949
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of CYP1A1 mRNA CTD PMID:16039398 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ddb1 damage-specific DNA binding protein 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of DDB1 mRNA CTD PMID:16039398 NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of DNAJA1 mRNA CTD PMID:16039398 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G Egr1 early growth response 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of EGR1 mRNA CTD PMID:16039398 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of EPHX2 mRNA CTD PMID:16039398 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [FMR1 5' UTR mutant form results in increased abundance of Hydroxyl Radical]; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [FMR1 5' UTR mutant form results in increased abundance of Superoxides] CTD PMID:27385396 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of GADD45A mRNA CTD PMID:16039398 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of GDF15 mRNA CTD PMID:16039398 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gsr glutathione-disulfide reductase decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of GSR mRNA CTD PMID:16039398 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstm3 glutathione S-transferase mu 3 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of GSTM3 mRNA CTD PMID:16039398
G Gstm5 glutathione S-transferase, mu 5 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of GSTM3 mRNA CTD PMID:16039398 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of HMOX1 mRNA CTD PMID:16039398 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hmox2 heme oxygenase 2 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HMOX2 mRNA CTD PMID:16039398 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
JBrowse link
G Hsf1 heat shock transcription factor 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSF1 mRNA CTD PMID:16039398 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSP90AA1 mRNA CTD PMID:16039398 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSPA1A mRNA CTD PMID:16039398
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSPA1B mRNA CTD PMID:16039398 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSPA1L mRNA CTD PMID:16039398 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSPA2 mRNA CTD PMID:16039398 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSPA4 mRNA CTD PMID:16039398 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSPA8 mRNA CTD PMID:16039398 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of HSPE1 mRNA CTD PMID:16039398 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression EXP Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of ICAM1 mRNA CTD PMID:17416599 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il18 interleukin 18 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of IL18 mRNA CTD PMID:16039398 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of IL1A mRNA CTD PMID:16039398 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Kcnj12 potassium inwardly-rectifying channel, subfamily J, member 12 multiple interactions ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [KCNJ12 protein results in increased transport of Potassium] CTD PMID:12118013 NCBI chr10:45,696,621...45,745,528
Ensembl chr10:45,696,849...45,745,492
JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 multiple interactions ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [KCNJ4 protein results in increased transport of Potassium] CTD PMID:12118013 NCBI chr 7:111,047,097...111,074,151
Ensembl chr 7:111,047,094...111,074,151
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of MDM2 mRNA CTD PMID:16039398 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mt1 metallothionein 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of MT1A mRNA CTD PMID:16039398 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of MT2A mRNA CTD PMID:16039398 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of NFKBIA mRNA CTD PMID:16039398 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nipa1 NIPA magnesium transporter 1 decreases expression EXP Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of NIPA1 mRNA CTD PMID:27157538 NCBI chr 1:106,834,000...106,875,148
Ensembl chr 1:106,834,000...106,874,790
JBrowse link
G Pdss1 decaprenyl diphosphate synthase subunit 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of PDSS1 mRNA CTD PMID:21308897 NCBI chr17:85,059,953...85,098,739
Ensembl chr17:85,060,106...85,098,730
JBrowse link
G Pdss2 decaprenyl diphosphate synthase subunit 2 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of PDSS2 mRNA CTD PMID:21308897 NCBI chr20:46,709,631...46,938,704
Ensembl chr20:46,709,649...46,938,708
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO PINK1 protein affects the reaction [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone affects the localization of PRKN protein] CTD PMID:24879156 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases phosphorylation ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased phosphorylation of PLCG1 protein CTD PMID:19901985 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone promotes the reaction [TARDBP protein binds to PPP1R15A protein] CTD PMID:29109149 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased phosphorylation of PRKAA1 protein CTD PMID:19901985 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions
affects localization
ISO PINK1 protein affects the reaction [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone affects the localization of PRKN protein] CTD PMID:24879156 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of PTGS2 mRNA CTD PMID:16039398 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of RAD23A mRNA CTD PMID:16039398 NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695
JBrowse link
G Rpl13a ribosomal protein L13A decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of RPL13A mRNA CTD PMID:16039398 NCBI chr 1:95,609,374...95,612,557 JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of SERPINE1 mRNA CTD PMID:16039398 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin] CTD PMID:1438304 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc41a2 solute carrier family 41 member 2 increases expression EXP Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of SLC41A2 mRNA CTD PMID:27157538 NCBI chr 7:20,383,714...20,491,178
Ensembl chr 7:20,383,757...20,491,166
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of SOD2 mRNA CTD PMID:16039398 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects response to substance ISO STAT3 protein affects the susceptibility to Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone CTD PMID:20224768 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone promotes the reaction [TARDBP protein binds to PPP1R15A protein] CTD PMID:29109149 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of XRCC5 mRNA CTD PMID:16039398 NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018
JBrowse link
CCCP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Glucose results in increased expression of AGT mRNA]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Glucose results in increased expression of AGT protein] CTD PMID:12130563 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ambra1 autophagy and beclin 1 regulator 1 multiple interactions ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [AMBRA1 protein binds to PRKN protein] CTD PMID:24879156 NCBI chr 3:77,700,936...77,890,221
Ensembl chr 3:77,700,936...77,890,221
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
increases phosphorylation
ISO ATM protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of COX4 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [PINK1 protein binds to ATM protein]
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of ATM protein
CTD PMID:29660402 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Becn1 beclin 1 multiple interactions ISO
EXP
Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]
BECN1 protein inhibits the reaction [BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]
BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PINK1 protein]; BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of and results in increased ubiquitination of MFN2 protein]; BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]
CTD PMID:24879156 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases phosphorylation
multiple interactions
ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of BNIP3L protein
BNIP3L protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of COX4 protein]; BNIP3L protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of HSPD1 protein]
CTD PMID:32142837 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Canx calnexin affects localization ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of CANX protein CTD PMID:28940366 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein] CTD PMID:33524445 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
EXP
ISO
Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Testosterone results in increased cleavage of CASP3 protein]
DNM1L protein promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP3 protein modified form]; PGAM5 protein promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP3 protein modified form]
CTD PMID:24658017 PMID:29241732 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases expression
multiple interactions
ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP9 protein modified form
DNM1L protein promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP9 protein modified form]
CTD PMID:29241732 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cirbp cold inducible RNA binding protein decreases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of CIRBP mRNA CTD PMID:15075239 NCBI chr 7:9,533,857...9,538,899 JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 decreases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of COX4I1 protein CTD PMID:27318970 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Ctsl cathepsin L increases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CTSL mRNA CTD PMID:15978749 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Dnm1l dynamin 1-like multiple interactions
decreases expression
ISO DNM1L protein promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP3 protein modified form]; DNM1L protein promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP9 protein modified form]
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of DNM1L protein modified form
CTD PMID:28940366 PMID:29241732 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Faslg Fas ligand multiple interactions EXP Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Testosterone results in increased expression of FASLG mRNA] CTD PMID:24658017 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of and affects the localization of PINK1 protein] promotes the reaction [FKBP5 protein binds to PINK1 protein] CTD PMID:30734931 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 decreases expression
multiple interactions
ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of FMC1 protein
bafilomycin A1 inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of FMC1 protein]
CTD PMID:29371327 NCBI chr 4:67,274,104...67,282,140
Ensembl chr 4:67,274,104...67,282,140
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression
multiple interactions
ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of HSPD1 protein
BNIP3L protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of HSPD1 protein]
CTD PMID:32142837 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA] CTD PMID:33524445 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [[Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in decreased activity of NFE2L2 protein; [Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein] CTD PMID:30715550 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Lep leptin multiple interactions
decreases response to substance
ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased susceptibility to LEP protein
CTD PMID:11342529 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lonp1 lon peptidase 1, mitochondrial increases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of LONP1 mRNA CTD PMID:28940366 NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771
JBrowse link
G Mapt microtubule-associated protein tau affects localization EXP Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of MAPT protein CTD PMID:17634376 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP
ISO
BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of and results in increased ubiquitination of MFN2 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of and results in increased ubiquitination of MFN2 protein
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of and affects the localization of MFN2 protein
CTD PMID:24879156 PMID:28940366 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [[Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in decreased activity of NFE2L2 protein; [Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein] CTD PMID:30715550 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of NFKB1 protein CTD PMID:15978749 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbib NFKB inhibitor beta decreases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of NFKBIB protein CTD PMID:15978749 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein] CTD PMID:33524445 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase decreases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of OPA1 protein alternative form CTD PMID:28940366 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO PARK7 gene mutant form promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein] CTD PMID:22872702 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase multiple interactions ISO PGAM5 protein promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP3 protein modified form] CTD PMID:29241732 NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [PIK3C3 protein binds to PRKN protein] CTD PMID:24879156 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions
affects localization
increases expression
increases stability
ISO
EXP
PINK1 gene mutant form inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]
BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PINK1 protein]; PINK1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]
[Carbonyl Cyanide m-Chlorophenyl Hydrazone co-treated with PRKN protein] results in increased expression of PINK1 protein; [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of and affects the localization of PINK1 protein] promotes the reaction [FKBP5 protein binds to PINK1 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [PINK1 protein binds to ATM protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of and affects the localization of PINK1 protein; Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of and results in increased phosphorylation of PINK1 protein
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of PINK1 protein
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased stability of PINK1 protein
CTD PMID:22872702 PMID:24879156 PMID:26070385 PMID:27318970 PMID:28673964 More... NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase affects localization
increases response to substance
decreases response to substance
affects expression
decreases expression
increases phosphorylation
multiple interactions
ISO
EXP
Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein
PRKN gene mutant form results in increased susceptibility to Carbonyl Cyanide m-Chlorophenyl Hydrazone
PRKN protein results in decreased susceptibility to Carbonyl Cyanide m-Chlorophenyl Hydrazone
Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the expression of PRKN protein alternative form
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of PRKN protein
Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of PRKN protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; Acetylcysteine inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]; PARK7 gene mutant form promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; PINK1 gene mutant form inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]
BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]; PINK1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]
[Carbonyl Cyanide m-Chlorophenyl Hydrazone co-treated with PRKN protein] results in increased expression of PINK1 protein; BECN1 protein inhibits the reaction [BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [AMBRA1 protein binds to PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [PIK3C3 protein binds to PRKN protein]; Tretinoin affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the expression of PRKN protein alternative form]
CTD PMID:16517603 PMID:22872702 PMID:24879156 PMID:26070385 PMID:28673964 More... NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]
Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Glucose results in increased expression of PTGS2 protein]
CTD PMID:14514642 PMID:16024921 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rbm3 RNA binding motif protein 3 decreases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of RBM3 mRNA CTD PMID:15075239 NCBI chr  X:14,348,909...14,352,387
Ensembl chr  X:14,348,910...14,353,580
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit increases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of REL protein CTD PMID:15978749 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Carbonyl Cyanide m-Chlorophenyl Hydrazone co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of RELA protein; Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased phosphorylation of RELA protein] CTD PMID:33524445 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [[Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in decreased activity of NFE2L2 protein; [Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein] CTD PMID:30715550 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Timm23 translocase of inner mitochondrial membrane 23 decreases expression ISO Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of TIMM23 protein CTD PMID:29371327 NCBI chr16:7,410,308...7,436,392
Ensembl chr16:7,409,688...7,436,379
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Testosterone results in increased expression of TNF mRNA]
Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF mRNA]
CTD PMID:24658017 PMID:33524445 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
Dibromoacetonitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hgf hepatocyte growth factor increases expression EXP dibromoacetonitrile results in increased expression of HGF mRNA CTD PMID:21986297 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression EXP dibromoacetonitrile results in increased expression of MET mRNA CTD PMID:21986297 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases oxidation
ISO 4-aminobenzhydrazide inhibits the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; 4-aminobenzhydrazide inhibits the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]; [MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides; Acetylcysteine promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Acetylcysteine promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]; Cysteine promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Cysteine promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]; Glutathione promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Glutathione promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]; Hydrogen Peroxide promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Hydrogen Peroxide promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]; Indomethacin inhibits the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Indomethacin inhibits the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]; Penicillamine promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Penicillamine promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]; Potassium Chloride promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Potassium Chloride promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]; Sodium Azide inhibits the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Sodium Azide inhibits the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]; Sodium Hypochlorite promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Sodium Hypochlorite promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile] CTD PMID:25614581 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP dibromoacetonitrile results in increased expression of MYC mRNA CTD PMID:21986297 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
Dichloroacetonitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acyp2 acylphosphatase 2 affects response to substance ISO ACYP2 gene SNP affects the susceptibility to dichloroacetonitrile CTD PMID:25622337 NCBI chr14:104,201,894...104,371,415
Ensembl chr14:104,201,895...104,371,386
JBrowse link
G Ano4 anoctamin 4 affects response to substance ISO ANO4 gene SNP affects the susceptibility to dichloroacetonitrile CTD PMID:25622337 NCBI chr 7:23,329,015...23,738,423
Ensembl chr 7:23,329,070...23,738,434
JBrowse link
G Cntn3 contactin 3 affects response to substance ISO CNTN3 gene SNP affects the susceptibility to dichloroacetonitrile CTD PMID:25622337 NCBI chr 4:134,841,268...135,214,460
Ensembl chr 4:134,842,266...135,125,613
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 affects response to substance ISO TRPM4 gene SNP affects the susceptibility to dichloroacetonitrile CTD PMID:25622337 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
JBrowse link
dienogest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 decreases expression ISO dienogest results in decreased expression of AKR1C2 mRNA CTD PMID:23183084 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein] CTD PMID:22014880 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd4 Cd4 molecule multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of CD4 protein CTD PMID:10813102 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Crp C-reactive protein multiple interactions ISO [Estradiol co-treated with dienogest] results in increased expression of CRP protein CTD PMID:15970291 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO dienogest results in decreased expression of CYP19A1 mRNA; dienogest results in decreased expression of CYP19A1 protein CTD PMID:22130322 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G F2 coagulation factor II multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in increased expression of F2 protein CTD PMID:15288212 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F7 coagulation factor VII multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in increased expression of F7 protein CTD PMID:15288212 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:15288212 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgb fibrinogen beta chain multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:15288212 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Fgg fibrinogen gamma chain multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in increased expression of [FGA protein binds to FGB protein binds to FGG protein] CTD PMID:15288212 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression ISO dienogest results in decreased expression of FSHB protein CTD PMID:11994349 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein]; dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein]; dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of IL6 protein]; dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 decreases expression ISO dienogest results in decreased expression of HSD17B2 mRNA CTD PMID:23183084 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of IGF1 protein CTD PMID:11172797 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il6 interleukin 6 multiple interactions ISO dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of IL6 protein] CTD PMID:22014880 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression ISO dienogest results in decreased expression of LHB protein CTD PMID:11994349 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
affects localization
ISO dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]
dienogest affects the localization of NFKB1 protein
CTD PMID:15866594 PMID:22130322 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PLAT protein CTD PMID:15288212 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in increased activity of PROC protein CTD PMID:15288212 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Pros1 protein S multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PROS1 protein CTD PMID:15288212 NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO dienogest results in decreased expression of PTGS2 mRNA; dienogest results in decreased expression of PTGS2 protein CTD PMID:22130322 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in decreased activity of SERPINC1 protein CTD PMID:15288212 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with dienogest] results in decreased expression of SERPINE1 protein CTD PMID:15288212 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]; dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 protein] CTD PMID:15866594 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
isobutyronitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases response to substance ISO CYP2E1 protein results in increased susceptibility to isobutyronitrile CTD PMID:22051853 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
oxomalononitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases response to substance
ISO PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to mesoxalonitrile] CTD PMID:12730627 NCBI chr13:22,689,783...22,853,920 JBrowse link
phoxim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP phoxim metabolite results in decreased activity of ACHE protein; phoxim results in decreased activity of ACHE protein CTD PMID:15793557 PMID:33497710 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ar androgen receptor multiple interactions ISO phoxim inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 affects expression ISO phoxim affects the expression of ARL6IP5 protein CTD PMID:15799245 NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP phoxim metabolite results in decreased activity of BCHE protein CTD PMID:33497710 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Cldn4 claudin 4 decreases expression
multiple interactions
EXP phoxim results in decreased expression of CLDN4 mRNA
Vitamin E inhibits the reaction [phoxim results in decreased expression of CLDN4 mRNA]
CTD PMID:30003487 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO phoxim binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression
multiple interactions
EXP phoxim results in increased expression of GPX2 mRNA
Vitamin E inhibits the reaction [phoxim results in increased expression of GPX2 mRNA]
CTD PMID:30003487 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP phoxim results in decreased expression of IL1B mRNA CTD PMID:30003487 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
EXP phoxim results in decreased expression of IL6 mRNA
Vitamin E inhibits the reaction [phoxim results in decreased expression of IL6 mRNA]
CTD PMID:30003487 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression EXP phoxim results in decreased expression of IRS2 mRNA CTD PMID:30090575 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression EXP phoxim results in increased expression of NFE2L2 mRNA CTD PMID:30003487 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO phoxim binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Ocln occludin multiple interactions
decreases expression
EXP Vitamin E inhibits the reaction [phoxim results in decreased expression of OCLN mRNA] CTD PMID:30003487 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO phoxim binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO phoxim binds to and results in decreased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [phoxim results in increased expression of TNF protein]
phoxim results in increased expression of TNF mRNA; phoxim results in increased expression of TNF protein
CTD PMID:30003487 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
pregnenolone 16alpha-carbonitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aacs acetoacetyl-CoA synthetase increases expression
decreases expression
multiple interactions
ISO Pregnenolone Carbonitrile results in increased expression of AACS mRNA
Pregnenolone Carbonitrile results in decreased expression of AACS mRNA
NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of AACS mRNA]
CTD PMID:22698814 PMID:28903501 NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954
JBrowse link
G Aadac arylacetamide deacetylase decreases expression
multiple interactions
ISO Pregnenolone Carbonitrile results in decreased expression of AADAC mRNA
NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in decreased expression of AADAC mRNA]
CTD PMID:22429928 PMID:28903501 NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734
JBrowse link
G Aadat aminoadipate aminotransferase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AADAT mRNA CTD PMID:19162173 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
JBrowse link
G Aass aminoadipate-semialdehyde synthase increases expression ISO Pregnenolone Carbonitrile results in increased expression of AASS mRNA CTD PMID:28903501 NCBI chr 4:51,606,461...51,663,136
Ensembl chr 4:51,606,462...51,663,136
JBrowse link
G Abat 4-aminobutyrate aminotransferase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ABAT mRNA CTD PMID:19162173 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ABCA1 mRNA; Pregnenolone Carbonitrile results in decreased expression of ABCA1 protein CTD PMID:15883047 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
increases expression
ISO Endotoxins inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB11 mRNA] CTD PMID:15456840 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO
EXP
Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein]
Pregnenolone Carbonitrile results in increased expression of ABCB1A mRNA
Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA; Pregnenolone Carbonitrile results in increased expression of ABCB1 protein; Pregnenolone Carbonitrile results in increased expression of ABCB1A mRNA
CTD PMID:15456840 PMID:16819505 PMID:19162173 PMID:29863087 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression ISO Pregnenolone Carbonitrile results in increased expression of ABCB1B mRNA CTD PMID:29863087 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression
decreases expression
EXP
ISO
Pregnenolone Carbonitrile results in increased expression of ABCB4 mRNA
Pregnenolone Carbonitrile results in decreased expression of ABCB4 mRNA
CTD PMID:19162173 PMID:28903501 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 multiple interactions ISO ABCB6 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA] CTD PMID:25623066 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ABCC1 mRNA CTD PMID:11752103 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
ISO
EXP
[Pregnenolone Carbonitrile co-treated with NR1I2 protein mutant form] results in increased expression of ABCC2 mRNA; Endotoxins inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCC2 mRNA]
Pregnenolone Carbonitrile results in increased expression of ABCC2 mRNA; Pregnenolone Carbonitrile results in increased expression of ABCC2 protein
CTD PMID:15456840 PMID:15917434 PMID:19118567 PMID:19162173 PMID:20888898 More... NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression
increases activity
ISO
EXP
[Pregnenolone Carbonitrile binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to ABCC3 gene]] which results in increased expression of ABCC3 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of ABCC3 mRNA]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to ABCC3 gene]
Pregnenolone Carbonitrile results in increased expression of ABCC3 mRNA; Pregnenolone Carbonitrile results in increased expression of ABCC3 protein
Pregnenolone Carbonitrile results in increased activity of ABCC3 protein
CTD PMID:14570758 PMID:15456840 PMID:15833929 PMID:15986414 PMID:19162173 More... NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects expression ISO Pregnenolone Carbonitrile affects the expression of ABCC4 mRNA CTD PMID:31388680 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcd4 ATP binding cassette subfamily D member 4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ABCD4 mRNA CTD PMID:28903501 NCBI chr 6:104,246,459...104,260,965
Ensembl chr 6:104,246,468...104,280,276
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression
multiple interactions
EXP
ISO
Pregnenolone Carbonitrile results in increased expression of ABCG5 mRNA
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of ABCG5 mRNA
CTD PMID:15683829 PMID:20359477 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ABCG8 mRNA CTD PMID:15683829 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Abhd14b abhydrolase domain containing 14b decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ABHD14B mRNA CTD PMID:28903501 NCBI chr 8:107,087,157...107,092,122
Ensembl chr 8:107,088,069...107,092,119
JBrowse link
G Abhd17b abhydrolase domain containing 17B, depalmitoylase increases expression ISO Pregnenolone Carbonitrile results in increased expression of ABHD17B mRNA CTD PMID:22698814 NCBI chr 1:219,198,294...219,232,733
Ensembl chr 1:219,198,471...219,231,933
JBrowse link
G Ablim1 actin-binding LIM protein 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ABLIM1 mRNA CTD PMID:28903501 NCBI chr 1:256,084,293...256,372,075 JBrowse link
G Ablim3 actin binding LIM protein family, member 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ABLIM3 mRNA CTD PMID:28903501 NCBI chr18:55,256,135...55,376,629
Ensembl chr18:55,257,583...55,376,380
JBrowse link
G Abtb2 ankyrin repeat and BTB domain containing 2 increases expression
decreases expression
EXP
ISO
Pregnenolone Carbonitrile results in increased expression of ABTB2 mRNA
Pregnenolone Carbonitrile results in decreased expression of ABTB2 mRNA
CTD PMID:19162173 PMID:28903501 NCBI chr 3:89,954,726...90,108,549
Ensembl chr 3:89,954,713...90,108,548
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACAA1B mRNA CTD PMID:28903501 NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ACAA2 mRNA CTD PMID:19162173 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of ACACA mRNA] CTD PMID:20359477 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ACAT1 mRNA CTD PMID:19162173 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 decreases expression EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of ACAT2 mRNA CTD PMID:19162173 PMID:28903501 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Acbd4 acyl-CoA binding domain containing 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACBD4 mRNA CTD PMID:28903501 NCBI chr10:88,048,058...88,062,612
Ensembl chr10:88,048,108...88,058,500
JBrowse link
G Acbd5 acyl-CoA binding domain containing 5 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACBD5 mRNA CTD PMID:28903501 NCBI chr17:85,206,178...85,248,909
Ensembl chr17:85,206,303...85,248,215
JBrowse link
G Acer2 alkaline ceramidase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ACER2 mRNA CTD PMID:28903501 NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614
JBrowse link
G Acly ATP citrate lyase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ACLY mRNA CTD PMID:19162173 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Aco2 aconitase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ACO2 mRNA CTD PMID:28903501 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
JBrowse link
G Acod1 aconitate decarboxylase 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACOD1 mRNA CTD PMID:22698814 NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529
JBrowse link
G Acot1 acyl-CoA thioesterase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ACOT1 mRNA CTD PMID:19162173 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
JBrowse link
G Acot2 acyl-CoA thioesterase 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ACOT2 mRNA CTD PMID:19162173 NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Acot3 acyl-CoA thioesterase 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACOT3 mRNA CTD PMID:27413110 NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,723,326...103,729,482
JBrowse link
G Acot4 acyl-CoA thioesterase 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACOT4 mRNA CTD PMID:28903501 NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917
JBrowse link
G Acot6 acyl-CoA thioesterase 6 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ACOT6 mRNA CTD PMID:22698814 NCBI chr 6:103,732,372...103,741,446
Ensembl chr 6:103,732,372...103,741,446
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ACOX1 mRNA CTD PMID:28903501 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acox2 acyl-CoA oxidase 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ACOX2 mRNA CTD PMID:19162173 NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression
multiple interactions
EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of ACSL1 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of ACSL1 mRNA]
CTD PMID:19162173 PMID:20359477 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACSL4 mRNA CTD PMID:28903501 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACSL5 mRNA CTD PMID:28903501 NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 decreases expression
increases expression
EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of ACSM2A mRNA
Pregnenolone Carbonitrile results in increased expression of ACSM2 mRNA
CTD PMID:19162173 PMID:22698814 NCBI chr 1:173,916,368...173,955,116
Ensembl chr 1:173,916,368...173,955,116
JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ACSM3 mRNA CTD PMID:19162173 NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184
JBrowse link
G Acsm5 acyl-CoA synthetase medium-chain family member 5 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACSM5 mRNA CTD PMID:28903501 NCBI chr 1:173,870,873...173,896,838
Ensembl chr 1:173,863,041...173,898,588
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACSS2 mRNA CTD PMID:28903501 NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO Pregnenolone Carbonitrile results in increased expression of ACTA2 mRNA CTD PMID:28903501 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actg1 actin, gamma 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ACTG1 mRNA CTD PMID:19162173 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
JBrowse link
G Acy3 aminoacylase 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACY3 mRNA CTD PMID:28903501 NCBI chr 1:201,279,751...201,285,803
Ensembl chr 1:201,279,851...201,283,175
JBrowse link
G Adamts14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ADAMTS14 mRNA CTD PMID:28903501 NCBI chr20:29,143,029...29,219,846
Ensembl chr20:29,144,354...29,219,866
JBrowse link
G Adamts15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ADAMTS15 mRNA CTD PMID:28903501 NCBI chr 8:29,307,864...29,331,249
Ensembl chr 8:29,307,865...29,331,249
JBrowse link
G Adamtsl2 ADAMTS-like 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ADAMTSL2 mRNA CTD PMID:28903501 NCBI chr 3:10,397,774...10,434,557
Ensembl chr 3:10,404,626...10,434,554
JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ADARB1 mRNA CTD PMID:28903501 NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852
JBrowse link
G Adck5 aarF domain containing kinase 5 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ADCK5 mRNA CTD PMID:28903501 NCBI chr 7:108,301,623...108,319,439
Ensembl chr 7:108,301,415...108,319,436
JBrowse link
G Adcy1 adenylate cyclase 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ADCY1 mRNA CTD PMID:28903501 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
JBrowse link
G Add1 adducin 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ADD1 mRNA CTD PMID:19162173 NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) decreases expression EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of ADH1 mRNA CTD PMID:19162173 PMID:28903501 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ADH4 mRNA CTD PMID:28903501 NCBI chr 2:226,948,717...226,966,747 JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ADH7 mRNA CTD PMID:28903501 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182
JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ADHFE1 mRNA CTD PMID:27413110 NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517
JBrowse link
G Adrb3 adrenoceptor beta 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ADRB3 mRNA CTD PMID:28903501 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Aen apoptosis enhancing nuclease increases expression ISO Pregnenolone Carbonitrile results in increased expression of AEN mRNA CTD PMID:28903501 NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
JBrowse link
G Afm afamin decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AFM mRNA CTD PMID:28903501 NCBI chr14:17,531,026...17,563,868
Ensembl chr14:17,531,024...17,563,870
JBrowse link
G Afp alpha-fetoprotein decreases expression
multiple interactions
ISO Pregnenolone Carbonitrile results in decreased expression of AFP mRNA
[Phenobarbital co-treated with Pregnenolone Carbonitrile co-treated with Diethylnitrosamine] results in increased expression of AFP mRNA
CTD PMID:27413110 PMID:28903501 PMID:33398415 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AGER mRNA CTD PMID:19162173 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Ago1 argonaute RISC component 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of AGO1 mRNA CTD PMID:22698814 NCBI chr 5:138,722,111...138,757,118
Ensembl chr 5:138,722,111...138,773,546
JBrowse link
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AGXT mRNA CTD PMID:19162173 NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336
JBrowse link
G Ahcy adenosylhomocysteinase increases expression ISO Pregnenolone Carbonitrile results in increased expression of AHCY mRNA CTD PMID:28903501 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein inhibits the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA]]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR mRNA]] CTD PMID:28428138 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AIF1 mRNA CTD PMID:19162173 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AIFM2 mRNA CTD PMID:19162173 NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236
JBrowse link
G Aifm3 apoptosis inducing factor, mitochondria associated 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AIFM3 mRNA CTD PMID:28903501 NCBI chr11:83,504,859...83,523,630
Ensembl chr11:83,504,861...83,521,248
JBrowse link
G Akap17a A-kinase anchoring protein 17A decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AKAP17B mRNA CTD PMID:28903501 NCBI chr12:16,310,427...16,315,166
Ensembl chr12:16,310,437...16,314,479
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases expression
multiple interactions
ISO Pregnenolone Carbonitrile results in increased expression of AKR1B7 mRNA
NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of AKR1B7 mRNA]
CTD PMID:25949234 PMID:27413110 PMID:28903501 NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AKR1C6 mRNA CTD PMID:28903501 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of AKR1D1 mRNA CTD PMID:28903501 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP Pregnenolone Carbonitrile results in increased expression of AKR7A3 mRNA CTD PMID:19162173 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression EXP
ISO
Pregnenolone Carbonitrile results in increased expression of ALAS1 mRNA CTD PMID:19162173 PMID:28903501 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression
multiple interactions
EXP
ISO
Pregnenolone Carbonitrile results in increased expression of ALDH1A1 mRNA
[Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to ALDH1A1 intron]] which results in increased expression of ALDH1A1 mRNA; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of ALDH1A1 mRNA]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to ALDH1A1 intron]
CTD PMID:17998271 PMID:19162173 PMID:20693526 PMID:22496397 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ALDH1B1 mRNA CTD PMID:17998271 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 increases expression
decreases expression
EXP
ISO
Pregnenolone Carbonitrile results in increased expression of ALDH1L1 mRNA
Pregnenolone Carbonitrile results in decreased expression of ALDH1L1 mRNA
CTD PMID:19162173 PMID:27413110 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ALDH3A2 mRNA CTD PMID:28903501 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ALDH4A1 mRNA CTD PMID:28903501 NCBI chr 5:151,880,002...151,905,491 JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ALDH6A1 mRNA CTD PMID:27413110 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ALDH8A1 mRNA CTD PMID:17998271 NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385
JBrowse link
G Aldob aldolase, fructose-bisphosphate B increases expression ISO Pregnenolone Carbonitrile results in increased expression of ALDOB mRNA CTD PMID:22698814 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ALOX5 mRNA CTD PMID:22698814 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Amacr alpha-methylacyl-CoA racemase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AMACR mRNA CTD PMID:19162173 NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor increases expression ISO Pregnenolone Carbonitrile results in increased expression of AMBP mRNA CTD PMID:28903501 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
JBrowse link
G Amn1 antagonist of mitotic exit network 1 homolog increases expression ISO Pregnenolone Carbonitrile results in increased expression of AMN1 mRNA CTD PMID:28903501 NCBI chr 4:182,155,140...182,182,085
Ensembl chr 4:182,155,142...182,182,016
JBrowse link
G Amph amphiphysin increases expression EXP Pregnenolone Carbonitrile results in increased expression of AMPH mRNA CTD PMID:19162173 NCBI chr17:45,739,385...45,982,905 JBrowse link
G Amt aminomethyltransferase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AMT mRNA CTD PMID:28903501 NCBI chr 8:108,981,620...108,988,127
Ensembl chr 8:108,976,472...108,988,126
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ANGPTL4 mRNA CTD PMID:28903501 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Ankib1 ankyrin repeat and IBR domain containing 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ANKIB1 mRNA CTD PMID:28903501 NCBI chr 4:30,333,678...30,457,781
Ensembl chr 4:30,333,677...30,457,781
JBrowse link
G Ankle1 ankyrin repeat and LEM domain containing 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ANKLE1 mRNA CTD PMID:22698814 NCBI chr16:18,076,413...18,082,356
Ensembl chr16:18,076,492...18,083,729
JBrowse link
G Ankrd24 ankyrin repeat domain 24 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ANKRD24 mRNA CTD PMID:19162173 NCBI chr 7:8,061,634...8,081,142
Ensembl chr 7:8,061,953...8,081,142
JBrowse link
G Anks4b ankyrin repeat and sterile alpha motif domain containing 4B decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ANKS4B mRNA CTD PMID:28903501 NCBI chr 1:174,534,195...174,557,798
Ensembl chr 1:174,547,473...174,557,797
JBrowse link
G Anpep alanyl aminopeptidase, membrane decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ANPEP mRNA CTD PMID:19162173 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
JBrowse link
G Anxa2 annexin A2 multiple interactions ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA2 mRNA] CTD PMID:20359477 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Anxa3 annexin A3 decreases expression
multiple interactions
EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of ANXA3 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA3 mRNA]
CTD PMID:19162173 PMID:20359477 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
JBrowse link
G Anxa4 annexin A4 multiple interactions ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA4 mRNA] CTD PMID:20359477 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
JBrowse link
G Anxa5 annexin A5 multiple interactions ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA5 mRNA] CTD PMID:20359477 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Ap3m1 adaptor related protein complex 3 subunit mu 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of AP3M1 mRNA CTD PMID:19162173 NCBI chr15:3,246,616...3,264,846
Ensembl chr15:3,246,926...3,264,844
JBrowse link
G Apba3 amyloid beta precursor protein binding family A member 3 increases expression EXP Pregnenolone Carbonitrile results in increased expression of APBA3 mRNA CTD PMID:19162173 NCBI chr 7:8,446,212...8,451,310
Ensembl chr 7:8,446,216...8,451,241
JBrowse link
G Apbb3 amyloid beta precursor protein binding family B member 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of APBB3 mRNA CTD PMID:28903501 NCBI chr18:28,273,168...28,280,347
Ensembl chr18:28,270,545...28,280,094
JBrowse link
G Apcs amyloid P component, serum increases expression ISO Pregnenolone Carbonitrile results in increased expression of APCS mRNA CTD PMID:28903501 NCBI chr13:85,373,338...85,374,134
Ensembl chr13:85,373,220...85,374,298
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression
increases expression
EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of APEX1 mRNA
Pregnenolone Carbonitrile results in increased expression of APEX1 mRNA
CTD PMID:19162173 PMID:28903501 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Aplp2 amyloid beta precursor like protein 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of APLP2 mRNA CTD PMID:19162173 NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855
JBrowse link
G Apoa1 apolipoprotein A1 increases expression EXP
ISO
Pregnenolone Carbonitrile results in increased expression of APOA1 mRNA CTD PMID:19162173 PMID:28903501 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apobec1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of APOBEC1 mRNA CTD PMID:19162173 NCBI chr 4:155,800,030...155,828,515
Ensembl chr 4:155,800,887...155,827,390
JBrowse link
G Apoc3 apolipoprotein C3 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of APOC3 mRNA CTD PMID:19162173 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
JBrowse link
G Apoc4 apolipoprotein C4 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of APOC4 mRNA CTD PMID:19162173 NCBI chr 1:79,335,745...79,339,942
Ensembl chr 1:79,335,745...79,339,981
JBrowse link
G Apol3 apolipoprotein L, 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of APOL9B mRNA CTD PMID:28903501 NCBI chr 7:109,288,725...109,297,728
Ensembl chr 7:109,288,725...109,297,723
JBrowse link
G Apol9a apolipoprotein L 9a decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of APOL9A mRNA CTD PMID:28903501 NCBI chr 7:109,140,871...109,149,799
Ensembl chr 7:109,140,871...109,147,649
JBrowse link
G App amyloid beta precursor protein increases expression EXP Pregnenolone Carbonitrile results in increased expression of APP mRNA CTD PMID:19162173 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp4 aquaporin 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AQP4 mRNA CTD PMID:28903501 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Aqp7 aquaporin 7 increases expression EXP Pregnenolone Carbonitrile results in increased expression of AQP7 mRNA CTD PMID:19162173 NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642
JBrowse link
G Aqp8 aquaporin 8 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AQP8 mRNA CTD PMID:28903501 NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
JBrowse link
G Aqp9 aquaporin 9 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AQP9 mRNA CTD PMID:19162173 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Ar androgen receptor increases expression EXP Pregnenolone Carbonitrile results in increased expression of AR mRNA CTD PMID:19162173 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ARHGAP29 mRNA CTD PMID:28903501 NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028
JBrowse link
G Arhgef16 Rho guanine nucleotide exchange factor 16 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ARHGEF16 mRNA CTD PMID:28903501 NCBI chr 5:164,843,656...164,866,212
Ensembl chr 5:164,844,161...164,866,212
JBrowse link
G Arhgef19 Rho guanine nucleotide exchange factor 19 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ARHGEF19 mRNA CTD PMID:28903501 NCBI chr 5:153,536,038...153,554,203
Ensembl chr 5:153,536,013...153,554,203
JBrowse link
G Arhgef26 Rho guanine nucleotide exchange factor 26 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ARHGEF26 mRNA CTD PMID:28903501 NCBI chr 2:146,740,336...146,850,918
Ensembl chr 2:146,739,631...146,850,819
JBrowse link
G Arhgef3 Rho guanine nucleotide exchange factor 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ARHGEF3 mRNA CTD PMID:28903501 NCBI chr16:2,301,573...2,581,951
Ensembl chr16:2,300,138...2,581,945
JBrowse link
G Arid5a AT-rich interaction domain 5A increases expression ISO Pregnenolone Carbonitrile results in increased expression of ARID5A mRNA CTD PMID:28903501 NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597
JBrowse link
G Arl4a ADP-ribosylation factor like GTPase 4A increases expression ISO Pregnenolone Carbonitrile results in increased expression of ARL4A mRNA CTD PMID:28903501 NCBI chr 6:57,079,496...57,084,156
Ensembl chr 6:57,078,812...57,085,066
JBrowse link
G Arl5a ADP-ribosylation factor like GTPase 5A increases expression EXP Pregnenolone Carbonitrile results in increased expression of ARL5A mRNA CTD PMID:19162173 NCBI chr 3:36,878,461...36,903,362
Ensembl chr 3:36,880,712...36,903,211
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ARNTL mRNA CTD PMID:27413110 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Arrb1 arrestin, beta 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ARRB1 mRNA CTD PMID:28903501 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Arrdc3 arrestin domain containing 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ARRDC3 mRNA CTD PMID:28903501 NCBI chr 2:11,137,443...11,149,978
Ensembl chr 2:11,137,460...11,149,978
JBrowse link
G Arsa arylsulfatase A decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ARSA mRNA CTD PMID:28903501 NCBI chr 7:120,542,788...120,547,577
Ensembl chr 7:120,543,362...120,548,783
JBrowse link
G Asb13 ankyrin repeat and SOCS box-containing 13 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ASB13 mRNA CTD PMID:28903501 NCBI chr17:66,564,653...66,583,365
Ensembl chr17:66,562,434...66,583,337
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone increases expression ISO Pregnenolone Carbonitrile results in increased expression of ASF1B mRNA CTD PMID:22698814 NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549
JBrowse link
G Asl argininosuccinate lyase increases expression ISO Pregnenolone Carbonitrile results in increased expression of ASL mRNA CTD PMID:28903501 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Pregnenolone Carbonitrile results in increased expression of ASNS mRNA CTD PMID:27413110 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Asprv1 aspartic peptidase, retroviral-like 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ASPRV1 mRNA CTD PMID:22698814 NCBI chr 4:119,076,169...119,078,887
Ensembl chr 4:119,077,356...119,078,379
JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ASS1 mRNA CTD PMID:19162173 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Atad1 ATPase family, AAA domain containing 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATAD1 mRNA CTD PMID:28903501 NCBI chr 1:230,544,227...230,610,524
Ensembl chr 1:230,544,047...230,596,548
JBrowse link
G Atad3a ATPase family, AAA domain containing 3A increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATAD3A mRNA CTD PMID:28903501 NCBI chr 5:166,350,302...166,370,492
Ensembl chr 5:166,350,304...166,370,482
JBrowse link
G Atat1 alpha tubulin acetyltransferase 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ATAT1 mRNA CTD PMID:28903501 NCBI chr20:2,844,595...2,857,809
Ensembl chr20:2,844,616...2,861,964
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
decreases expression
ISO NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of ATF3 mRNA] CTD PMID:22698814 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atg14 autophagy related 14 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATG14 mRNA CTD PMID:28903501 NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113
JBrowse link
G Atl2 atlastin GTPase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATL2 mRNA CTD PMID:28903501 NCBI chr 6:15,139,071...15,180,421
Ensembl chr 6:15,139,044...15,180,421
JBrowse link
G Atp10d ATPase phospholipid transporting 10D (putative) increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATP10D mRNA CTD PMID:28903501 NCBI chr14:35,911,728...36,012,549
Ensembl chr14:35,912,141...36,012,564
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ATP1B1 mRNA CTD PMID:19162173 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
JBrowse link
G Atp4a ATPase H+/K+ transporting subunit alpha increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATP4A mRNA CTD PMID:22698814 NCBI chr 1:85,961,607...85,974,972
Ensembl chr 1:85,961,708...85,974,844
JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ATPIF1 mRNA CTD PMID:19162173 NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668
JBrowse link
G Atp5me ATP synthase membrane subunit e increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATP5K mRNA CTD PMID:28903501 NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013
JBrowse link
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATP6V0A4 mRNA CTD PMID:28903501 NCBI chr 4:66,760,159...66,842,110
Ensembl chr 4:66,760,159...66,842,110
JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D increases expression EXP Pregnenolone Carbonitrile results in increased expression of ATP6V1D mRNA CTD PMID:19162173 NCBI chr 6:97,656,725...97,672,211
Ensembl chr 6:97,656,576...97,672,303
JBrowse link
G Atrn attractin decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ATRN mRNA CTD PMID:19162173 NCBI chr 3:118,110,320...118,244,326
Ensembl chr 3:118,110,229...118,244,322
JBrowse link
G Atxn7l1 ataxin 7-like 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ATXN7L1 mRNA CTD PMID:28903501 NCBI chr 6:49,759,876...49,982,323
Ensembl chr 6:49,759,883...49,982,320
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AVPR1A mRNA CTD PMID:19162173 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Axin2 axin 2 multiple interactions ISO [Phenobarbital co-treated with Pregnenolone Carbonitrile co-treated with Diethylnitrosamine] results in increased expression of AXIN2 mRNA CTD PMID:33398415 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link
G B3galt1 Beta-1,3-galactosyltransferase 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of B3GALT1 mRNA CTD PMID:28903501 NCBI chr 3:52,253,413...52,826,508
Ensembl chr 3:52,253,618...52,825,313
JBrowse link
G B3gntl1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of B3GNTL1 mRNA CTD PMID:19162173 NCBI chr10:106,870,237...106,933,723
Ensembl chr10:106,873,169...106,933,637
JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of B4GALT1 mRNA CTD PMID:28903501 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase increases expression ISO Pregnenolone Carbonitrile results in increased expression of BAAT mRNA CTD PMID:27413110 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of BAD mRNA CTD PMID:19162173 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of BAIAP2 mRNA CTD PMID:28903501 NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of BAK1 protein CTD PMID:19433268 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of BAX protein CTD PMID:19433268 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcat2 branched chain amino acid transaminase 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of BCAT2 mRNA CTD PMID:28903501 NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007
JBrowse link
G Bche butyrylcholinesterase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of BCHE mRNA CTD PMID:28903501 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Pregnenolone Carbonitrile results in increased expression of BCL2 mRNA CTD PMID:19162173 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of BCL2A1B mRNA CTD PMID:22698814 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of BCL2L1 mRNA]
Pregnenolone Carbonitrile results in increased expression of BCL2L1 mRNA
CTD PMID:19433268 PMID:28903501 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bco2 beta-carotene oxygenase 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of BCO2 mRNA CTD PMID:28903501 NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467
JBrowse link
G Bcor BCL6 co-repressor increases expression ISO Pregnenolone Carbonitrile results in increased expression of BCOR mRNA CTD PMID:28903501 NCBI chr  X:10,609,756...10,729,613
Ensembl chr  X:10,687,732...10,729,613
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of BDH1 mRNA CTD PMID:28903501 NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase increases expression ISO Pregnenolone Carbonitrile results in increased expression of BHMT mRNA CTD PMID:28903501 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Bin1 bridging integrator 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of BIN1 mRNA CTD PMID:19162173 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression
multiple interactions
ISO Pregnenolone Carbonitrile results in increased expression of BIRC5 mRNA
[Phenobarbital co-treated with Pregnenolone Carbonitrile co-treated with Diethylnitrosamine] results in increased expression of BIRC5 mRNA
CTD PMID:22698814 PMID:28903501 PMID:33398415 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bivm basic, immunoglobulin-like variable motif containing decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of BIVM mRNA CTD PMID:28903501 NCBI chr 9:46,268,758...46,305,038
Ensembl chr 9:46,269,252...46,305,024
JBrowse link
G Bmper BMP-binding endothelial regulator increases expression ISO Pregnenolone Carbonitrile results in increased expression of BMPER mRNA CTD PMID:28903501 NCBI chr 8:21,732,225...21,977,261
Ensembl chr 8:21,732,225...21,977,256
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of BNIP3 mRNA CTD PMID:28903501 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression EXP Pregnenolone Carbonitrile results in increased expression of BNIP3L mRNA CTD PMID:19162173 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of BRCA1 mRNA CTD PMID:23626729 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of BRCA2 mRNA CTD PMID:23626729 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of BRCC3 mRNA CTD PMID:19162173 NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080
JBrowse link
G Brix1 biogenesis of ribosomes BRX1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of BRIX1 mRNA CTD PMID:28903501 NCBI chr 2:59,450,608...59,461,486
Ensembl chr 2:59,450,614...59,461,495
JBrowse link
G Btf3 basic transcription factor 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of BTF3 mRNA CTD PMID:28903501 NCBI chr 2:29,659,764...29,666,898
Ensembl chr 2:29,659,231...29,666,879
JBrowse link
G C1qb complement C1q B chain decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of C1QB mRNA CTD PMID:19162173 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
JBrowse link
G C1r complement C1r decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of C1R mRNA CTD PMID:19162173 NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
JBrowse link
G C3 complement C3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of C3 mRNA CTD PMID:28903501 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C4a complement C4A increases expression ISO Pregnenolone Carbonitrile results in increased expression of C4A mRNA CTD PMID:28903501 NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080
JBrowse link
G Ca14 carbonic anhydrase 14 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CAR14 mRNA CTD PMID:28903501 NCBI chr 2:183,442,263...183,449,207
Ensembl chr 2:183,441,667...183,449,693
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of CAR3 mRNA CTD PMID:19162173 PMID:28903501 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Ca9 carbonic anhydrase 9 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CAR9 mRNA CTD PMID:22698814 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D increases expression ISO Pregnenolone Carbonitrile results in increased expression of CACNA1D mRNA CTD PMID:22698814 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CACNB4 mRNA CTD PMID:28903501 NCBI chr 3:36,906,771...37,169,191
Ensembl chr 3:36,910,427...37,168,944
JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CAMK2N1 mRNA CTD PMID:19162173 NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CAMKK2 mRNA CTD PMID:19162173 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
JBrowse link
G Camsap2 calmodulin regulated spectrin-associated protein family, member 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CAMSAP2 mRNA CTD PMID:22698814 NCBI chr13:47,723,121...47,802,597
Ensembl chr13:47,723,121...47,802,597
JBrowse link
G Casp1 caspase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CASP1 mRNA CTD PMID:19162173 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
EXP
ISO
Pregnenolone Carbonitrile results in increased expression of CASP3 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased cleavage of CASP3 protein]
CTD PMID:19162173 PMID:19433268 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CASP6 mRNA CTD PMID:19162173 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Cavin3 caveolae associated protein 3 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CAVIN3 mRNA CTD PMID:19162173 NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161
JBrowse link
G Cbx2 chromobox 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CBX2 mRNA CTD PMID:28903501 NCBI chr10:104,278,517...104,287,384
Ensembl chr10:104,278,549...104,287,383
JBrowse link
G Cbx4 chromobox 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CBX4 mRNA CTD PMID:28903501 NCBI chr10:104,337,140...104,343,210 JBrowse link
G Cbx5 chromobox 5 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CBX5 mRNA CTD PMID:19162173 NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022
JBrowse link
G Cbx8 chromobox 8 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CBX8 mRNA CTD PMID:28903501 NCBI chr10:104,294,518...104,296,956
Ensembl chr10:104,294,518...104,297,024
JBrowse link
G Cc2d2a coiled-coil and C2 domain containing 2A decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CC2D2A mRNA CTD PMID:28903501 NCBI chr14:67,349,004...67,435,883
Ensembl chr14:67,351,353...67,435,949
JBrowse link
G Ccdc86 coiled-coil domain containing 86 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CCDC86 mRNA CTD PMID:28903501 NCBI chr 1:207,590,946...207,596,527
Ensembl chr 1:207,590,168...207,596,544
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO Pregnenolone Carbonitrile results in decreased expression of CCL2 mRNA
NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of CCL2 mRNA]
CTD PMID:22698814 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CCL6 mRNA CTD PMID:28903501 NCBI chr10:68,381,179...68,385,811
Ensembl chr10:68,380,188...68,384,001
JBrowse link
G Ccn1 cellular communication network factor 1 decreases expression
multiple interactions
ISO Pregnenolone Carbonitrile results in decreased expression of CCN1 mRNA
[Phenobarbital co-treated with Pregnenolone Carbonitrile co-treated with Diethylnitrosamine] results in increased expression of CYR61 mRNA
CTD PMID:28903501 PMID:33398415 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CCN2 mRNA CTD PMID:28903501 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of CCNA2 mRNA; [Phenobarbital co-treated with Pregnenolone Carbonitrile] results in increased expression of CCNA2 mRNA; [pirinixic acid co-treated with Pregnenolone Carbonitrile] results in increased expression of CCNA2 mRNA; [Pregnenolone Carbonitrile co-treated with Phenobarbital] results in increased expression of CCNA2 mRNA CTD PMID:23626729 PMID:33398415 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions
EXP
ISO
Pregnenolone Carbonitrile results in increased expression of CCNB1 mRNA
[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of CCNB1 mRNA; [pirinixic acid co-treated with Pregnenolone Carbonitrile] results in increased expression of CCNB1 mRNA
CTD PMID:19162173 PMID:23626729 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb2 cyclin B2 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of CCNB2 mRNA CTD PMID:23626729 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccnd1 cyclin D1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CCND1 mRNA CTD PMID:19162173 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnf cyclin F decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CCNF mRNA CTD PMID:28903501 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CCT2 mRNA CTD PMID:28903501 NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944
JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CCT3 mRNA CTD PMID:28903501 NCBI chr 2:173,765,792...173,790,353
Ensembl chr 2:173,765,698...173,790,757
JBrowse link
G Cd19 CD19 molecule decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CD19 mRNA CTD PMID:28903501 NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975
JBrowse link
G Cd22 CD22 molecule decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CD22 mRNA CTD PMID:28903501 NCBI chr 1:86,116,376...86,132,782
Ensembl chr 1:86,117,459...86,132,322
JBrowse link
G Cd36 CD36 molecule decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CD36 mRNA CTD PMID:19162173 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd74 CD74 molecule decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CD74 mRNA CTD PMID:19162173 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
JBrowse link
G Cd81 Cd81 molecule decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CD81 mRNA CTD PMID:19162173 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660
JBrowse link
G Cd82 Cd82 molecule increases expression EXP Pregnenolone Carbonitrile results in increased expression of CD82 mRNA CTD PMID:19162173 NCBI chr 3:79,387,361...79,431,847
Ensembl chr 3:79,385,887...79,431,809
JBrowse link
G Cdc14b cell division cycle 14B decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CDC14B mRNA CTD PMID:28903501 NCBI chr17:844,731...934,787
Ensembl chr17:844,685...933,235
JBrowse link
G Cdc20 cell division cycle 20 increases expression
multiple interactions
EXP
ISO
Pregnenolone Carbonitrile results in increased expression of CDC20 mRNA
NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CDC20 mRNA]
CTD PMID:19162173 PMID:21318169 PMID:22698814 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc45 cell division cycle 45 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDC45 mRNA CTD PMID:22698814 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619
JBrowse link
G Cdca3 cell division cycle associated 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDCA3 mRNA CTD PMID:22698814 NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799
JBrowse link
G Cdca8 cell division cycle associated 8 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDCA8 mRNA CTD PMID:22698814 NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
JBrowse link
G Cdh15 cadherin 15 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDH15 mRNA CTD PMID:28903501 NCBI chr19:50,903,757...50,927,151
Ensembl chr19:50,903,638...50,927,105
JBrowse link
G Cdh2 cadherin 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CDH2 mRNA CTD PMID:19162173 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdhr5 cadherin-related family member 5 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDHR5 mRNA CTD PMID:28903501 NCBI chr 1:196,373,110...196,381,609
Ensembl chr 1:196,373,112...196,381,543
JBrowse link
G Cdip1 cell death-inducing p53 target 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDIP1 mRNA CTD PMID:28903501 NCBI chr10:10,773,538...10,796,979
Ensembl chr10:10,774,705...10,796,980
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression
multiple interactions
ISO Pregnenolone Carbonitrile results in increased expression of CDK1 mRNA
NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CDK1 mRNA]
CTD PMID:22698814 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk18 cyclin-dependent kinase 18 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDK18 mRNA CTD PMID:28903501 NCBI chr13:43,555,597...43,582,210
Ensembl chr13:43,556,748...43,588,525
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDKN1A mRNA CTD PMID:28903501 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDKN3 mRNA CTD PMID:22698814 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Cdo1 cysteine dioxygenase type 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CDO1 mRNA CTD PMID:19162173 NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CEBPA mRNA CTD PMID:28903501 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression EXP
ISO
Pregnenolone Carbonitrile results in increased expression of CEBPB mRNA CTD PMID:19162173 PMID:28903501 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression ISO Pregnenolone Carbonitrile results in increased expression of CEBPD mRNA CTD PMID:28903501 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Cebpzos CEBPZ opposite strand increases expression ISO Pregnenolone Carbonitrile results in increased expression of CEBPZOS mRNA CTD PMID:28903501 NCBI chr 6:16,135,546...16,140,254 JBrowse link
G Celf1 CUGBP, Elav-like family member 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CELF1 mRNA CTD PMID:19162173 NCBI chr 3:76,924,591...76,999,429
Ensembl chr 3:76,924,613...76,999,426
JBrowse link
G Cenpe centromere protein E increases expression ISO Pregnenolone Carbonitrile results in increased expression of CENPE mRNA CTD PMID:22698814 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Cenph centromere protein H increases expression ISO Pregnenolone Carbonitrile results in increased expression of CENPH mRNA CTD PMID:22698814 NCBI chr 2:31,894,253...31,910,182
Ensembl chr 2:31,894,667...31,910,154
JBrowse link
G Cenpp centromere protein P increases expression ISO Pregnenolone Carbonitrile results in increased expression of CENPP mRNA CTD PMID:22698814 NCBI chr17:15,013,869...15,189,312
Ensembl chr17:15,014,058...15,189,304
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
increases expression
ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CES1D mRNA]
Pregnenolone Carbonitrile results in increased expression of CES1D mRNA; Pregnenolone Carbonitrile results in increased expression of CES1D protein
CTD PMID:20359477 PMID:26179144 PMID:28903501 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Ces2c carboxylesterase 2C multiple interactions
increases expression
ISO NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of CES2C mRNA] CTD PMID:22429928 PMID:26179144 NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790
JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP Pregnenolone Carbonitrile results in increased expression of CES2 mRNA CTD PMID:19162173 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Ces3a carboxylesterase 3a decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CES3B mRNA CTD PMID:28903501 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Cgn cingulin decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CGN mRNA CTD PMID:28903501 NCBI chr 2:182,308,389...182,335,747
Ensembl chr 2:182,308,714...182,334,645
JBrowse link
G Ch25h cholesterol 25-hydroxylase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CH25H mRNA CTD PMID:22698814 NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195
JBrowse link
G Chac2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CHAC2 mRNA CTD PMID:28903501 NCBI chr14:104,720,754...104,728,305
Ensembl chr14:104,720,758...104,728,301
JBrowse link
G Chaf1a chromatin assembly factor 1 subunit A increases expression
decreases expression
ISO Pregnenolone Carbonitrile results in increased expression of CHAF1A mRNA
Pregnenolone Carbonitrile results in decreased expression of CHAF1A mRNA
CTD PMID:22698814 PMID:28903501 NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654
JBrowse link
G Chchd4 coiled-coil-helix-coiled-coil-helix domain containing 4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CHCHD4 mRNA CTD PMID:28903501 NCBI chr 4:123,968,264...123,977,398
Ensembl chr 4:123,968,265...123,977,414
JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CHCHD6 mRNA CTD PMID:19162173 NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216
JBrowse link
G Chd1l chromodomain helicase DNA binding protein 1-like increases expression ISO Pregnenolone Carbonitrile results in increased expression of CHD1L mRNA CTD PMID:28903501 NCBI chr 2:185,138,526...185,217,498
Ensembl chr 2:185,139,308...185,217,595
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of CHEK1 mRNA CTD PMID:23626729 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chka choline kinase alpha decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CHKA mRNA CTD PMID:28903501 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CHORDC1 mRNA CTD PMID:19162173 NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162
JBrowse link
G Chpt1 choline phosphotransferase 1 multiple interactions ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of CHPT1 mRNA CTD PMID:20359477 NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CHRM1 mRNA CTD PMID:19162173 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CHRM3 mRNA CTD PMID:19162173 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
JBrowse link
G Chst15 carbohydrate sulfotransferase 15 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CHST15 mRNA CTD PMID:28903501 NCBI chr 1:187,028,860...187,107,908
Ensembl chr 1:187,028,970...187,107,707
JBrowse link
G Chtf18 chromosome transmission fidelity factor 18 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CHTF18 mRNA CTD PMID:22698814 NCBI chr10:14,743,006...14,751,044
Ensembl chr10:14,742,621...14,751,050
JBrowse link
G Ciao1 cytosolic iron-sulfur assembly component 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CIAO1 mRNA CTD PMID:19162173 NCBI chr 3:114,458,671...114,465,928
Ensembl chr 3:114,458,655...114,467,009
JBrowse link
G Cidea cell death-inducing DFFA-like effector a increases expression EXP Pregnenolone Carbonitrile results in increased expression of CIDEA mRNA CTD PMID:19162173 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
JBrowse link
G Ciita class II, major histocompatibility complex, transactivator decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CIITA mRNA CTD PMID:22698814 NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of CITED2 mRNA CTD PMID:19162173 PMID:28903501 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Ckb creatine kinase B decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CKB mRNA CTD PMID:19162173 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of CKS1B mRNA CTD PMID:23626729 NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CKS2 mRNA CTD PMID:28903501 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Cldn14 claudin 14 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CLDN14 mRNA CTD PMID:28903501 NCBI chr11:33,232,281...33,329,440
Ensembl chr11:33,232,220...33,329,171
JBrowse link
G Cldn3 claudin 3 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CLDN3 mRNA CTD PMID:19162173 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
JBrowse link
G Clec4d C-type lectin domain family 4, member D decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CLEC4D mRNA CTD PMID:22698814 NCBI chr 4:156,589,591...156,598,969
Ensembl chr 4:156,589,792...156,598,848
JBrowse link
G Clec9a C-type lectin domain containing 9A increases expression ISO Pregnenolone Carbonitrile results in increased expression of CLEC9A mRNA CTD PMID:28903501 NCBI chr 4:162,859,742...162,875,742
Ensembl chr 4:162,860,308...162,875,352
JBrowse link
G Clic3 chloride intracellular channel 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CLIC3 mRNA CTD PMID:28903501 NCBI chr 3:8,271,416...8,274,023
Ensembl chr 3:8,272,097...8,274,018
JBrowse link
G Clstn3 calsyntenin 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CLSTN3 mRNA CTD PMID:28903501 NCBI chr 4:157,331,494...157,364,769
Ensembl chr 4:157,331,494...157,364,769
JBrowse link
G Cltb clathrin, light chain B increases expression EXP
ISO
Pregnenolone Carbonitrile results in increased expression of CLTB mRNA CTD PMID:19162173 PMID:28903501 NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169
JBrowse link
G Clu clusterin increases expression ISO Pregnenolone Carbonitrile results in increased expression of CLU mRNA CTD PMID:28903501 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cnrip1 cannabinoid receptor interacting protein 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CNRIP1 mRNA CTD PMID:22698814 NCBI chr14:91,463,046...91,492,736
Ensembl chr14:91,462,647...91,492,735
JBrowse link
G Cntn5 contactin 5 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CNTN5 mRNA CTD PMID:22698814 NCBI chr 8:6,735,715...7,967,727
Ensembl chr 8:6,738,239...7,967,957
JBrowse link
G Col15a1 collagen type XV alpha 1 chain decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of COL15A1 mRNA CTD PMID:28903501 NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591
JBrowse link
G Colgalt2 collagen beta(1-O)galactosyltransferase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of COLGALT2 mRNA CTD PMID:22698814 PMID:28903501 NCBI chr13:64,523,641...64,628,295
Ensembl chr13:64,523,658...64,627,549
JBrowse link
G Comt catechol-O-methyltransferase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of COMT mRNA CTD PMID:19162173 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Coro2a coronin 2A decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CORO2A mRNA CTD PMID:28903501 NCBI chr 5:60,825,630...60,881,917
Ensembl chr 5:60,828,247...60,859,035
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of COX5A mRNA CTD PMID:19162173 NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781
JBrowse link
G Cox8a cytochrome c oxidase subunit 8A decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of COX8A mRNA CTD PMID:19162173 NCBI chr 1:204,402,118...204,404,439 JBrowse link
G Cpb2 carboxypeptidase B2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CPB2 mRNA CTD PMID:28903501 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556
JBrowse link
G Cpeb2 cytoplasmic polyadenylation element binding protein 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CPEB2 mRNA CTD PMID:22698814 NCBI chr14:67,787,503...67,839,973
Ensembl chr14:67,787,507...67,840,743
JBrowse link
G Cpne8 copine 8 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CPNE8 mRNA CTD PMID:28903501 NCBI chr 7:121,615,293...121,789,507
Ensembl chr 7:121,615,294...121,790,377
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CPS1 mRNA CTD PMID:19162173 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CPT1B mRNA CTD PMID:19162173 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Cpxm2 carboxypeptidase X (M14 family), member 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CPXM2 mRNA CTD PMID:22698814 NCBI chr 1:186,836,797...186,947,222
Ensembl chr 1:186,836,797...186,947,220
JBrowse link
G Crcp CGRP receptor component increases expression ISO Pregnenolone Carbonitrile results in increased expression of CRCP mRNA CTD PMID:28903501 NCBI chr12:26,623,968...26,659,756
Ensembl chr12:26,623,976...26,768,225
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CREG1 mRNA CTD PMID:19162173 NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308
JBrowse link
G Crip2 cysteine-rich protein 2 decreases expression
increases expression
EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of CRIP2 mRNA
Pregnenolone Carbonitrile results in increased expression of CRIP2 mRNA
CTD PMID:19162173 PMID:28903501 NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065
JBrowse link
G Crot carnitine O-octanoyltransferase decreases expression
multiple interactions
EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of CROT mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CROT mRNA]
CTD PMID:19162173 PMID:20359477 PMID:28903501 NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
JBrowse link
G Crp C-reactive protein increases expression ISO Pregnenolone Carbonitrile results in increased expression of CRP mRNA CTD PMID:28903501 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cryaa crystallin, alpha A increases expression EXP Pregnenolone Carbonitrile results in increased expression of CRYAA mRNA CTD PMID:19162173 NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349
JBrowse link
G Crybb1 crystallin, beta B1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CRYBB1 mRNA CTD PMID:22698814 NCBI chr12:44,369,734...44,383,344
Ensembl chr12:44,369,735...44,383,344
JBrowse link
G Crybb3 crystallin, beta B3 decreases expression
increases expression
ISO Pregnenolone Carbonitrile results in decreased expression of CRYBB3 mRNA
Pregnenolone Carbonitrile results in increased expression of CRYBB3 mRNA
CTD PMID:22698814 PMID:28903501 NCBI chr12:43,557,103...43,562,120
Ensembl chr12:43,557,103...43,562,120
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression ISO Pregnenolone Carbonitrile results in increased expression of CSF2RB mRNA; Pregnenolone Carbonitrile results in increased expression of CSF2RB2 mRNA CTD PMID:28903501 NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CSRNP1 mRNA CTD PMID:28903501 NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
JBrowse link
G Cstb cystatin B decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CSTB mRNA CTD PMID:19162173 NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526
JBrowse link
G Cth cystathionine gamma-lyase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CTH mRNA CTD PMID:19162173 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Ctnnd2 catenin delta 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CTNND2 mRNA CTD PMID:19162173 NCBI chr 2:81,168,976...82,016,495
Ensembl chr 2:81,167,117...82,015,764
JBrowse link
G Ctps1 CTP synthase 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CTPS mRNA CTD PMID:28903501 NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180
JBrowse link
G Ctsd cathepsin D increases expression EXP Pregnenolone Carbonitrile results in increased expression of CTSD mRNA CTD PMID:19162173 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctsl cathepsin L decreases expression
increases expression
EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of CTSL mRNA
Pregnenolone Carbonitrile results in increased expression of CTSL mRNA
CTD PMID:19162173 PMID:28903501 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Ctss cathepsin S decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CTSS mRNA CTD PMID:19162173 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cuta cutA divalent cation tolerance homolog decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CUTA mRNA CTD PMID:19162173 NCBI chr20:5,022,956...5,024,580
Ensembl chr20:5,022,956...5,024,552
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CXCL1 mRNA CTD PMID:27413110 PMID:28903501 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyb561 cytochrome b-561 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CYB561 mRNA CTD PMID:28903501 NCBI chr10:90,878,052...90,888,734
Ensembl chr10:90,878,054...90,884,787
JBrowse link
G Cyb5a cytochrome b5 type A affects expression
increases expression
EXP
ISO
Pregnenolone Carbonitrile affects the expression of CYB5A mRNA
Pregnenolone Carbonitrile results in increased expression of CYB5A mRNA
CTD PMID:19162173 PMID:28903501 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYB5R3 mRNA CTD PMID:19162173 NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
JBrowse link
G Cyc1 cytochrome c-1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYC1 mRNA CTD PMID:19162173 NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479
JBrowse link
G Cycs cytochrome c, somatic decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYCS mRNA CTD PMID:19162173 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP17A1 mRNA CTD PMID:19162173 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression
multiple interactions
increases expression
EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of CYP1A1 mRNA
Pregnenolone Carbonitrile inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]
Pregnenolone Carbonitrile results in increased expression of CYP1A1 mRNA
CTD PMID:19118567 PMID:19162173 PMID:28428138 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
multiple interactions
increases expression
EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of CYP1A2 mRNA
NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in decreased expression of CYP1A2 mRNA]
Pregnenolone Carbonitrile inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA]
Pregnenolone Carbonitrile results in increased expression of CYP1A2 mRNA
CTD PMID:15596064 PMID:19162173 PMID:27413110 PMID:28428138 PMID:29548889 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO Pregnenolone Carbonitrile inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA] CTD PMID:28428138 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CYP21A1 mRNA CTD PMID:28903501 NCBI chr20:4,020,217...4,026,923
Ensembl chr20:4,023,767...4,026,923
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CYP24A1 mRNA CTD PMID:15630458 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CYP26A1 mRNA CTD PMID:28903501 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CYP27A1 mRNA CTD PMID:28903501 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP2A1 mRNA CTD PMID:15596064 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP2A2 mRNA CTD PMID:19162173 NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CYP2A5 mRNA CTD PMID:27413110 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
affects expression
increases expression
ISO
EXP
[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP2B10 mRNA; [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP2B10 mRNA; [Phenobarbital co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP2B10 mRNA; [Pregnenolone Carbonitrile co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA; [Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to CYP2B10 gene]] which results in increased expression of CYP2B10 mRNA; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2B10 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2B10 mRNA]; NR1I3 protein promotes the reaction [[Pregnenolone Carbonitrile co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to CYP2B10 gene]; Pregnenolone Carbonitrile promotes the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]
Pregnenolone Carbonitrile affects the expression of CYP2B10 mRNA
Pregnenolone Carbonitrile results in increased expression of CYP2B1 mRNA
NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2B1 mRNA]
Pregnenolone Carbonitrile results in increased expression of CYP2B10 mRNA; Pregnenolone Carbonitrile results in increased expression of CYP2B10 protein
CTD PMID:15986414 PMID:17627975 PMID:18488193 PMID:19433268 PMID:20359477 More... NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP2B15 mRNA CTD PMID:19162173 PMID:19850644 NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression
multiple interactions
EXP
ISO
Pregnenolone Carbonitrile results in increased expression of CYP2B2 mRNA
NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2B2 mRNA]
Pregnenolone Carbonitrile results in increased expression of CYP2B13 mRNA
CTD PMID:15596064 PMID:19162173 PMID:19850644 PMID:27413110 PMID:29548889 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression
increases expression
EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of CYP2B3 mRNA
Pregnenolone Carbonitrile results in decreased expression of CYP2B9 mRNA
Pregnenolone Carbonitrile results in increased expression of CYP2B3 mRNA
CTD PMID:15596064 PMID:19162173 PMID:27413110 PMID:28903501 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP2C mRNA CTD PMID:19162173 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP2C22 mRNA CTD PMID:19162173 NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions
increases expression
ISO NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2C55 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2C55 mRNA] CTD PMID:20371638 PMID:22698814 PMID:27413110 PMID:28903501 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CYP2C38 mRNA CTD PMID:28903501 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CYP2C29 mRNA CTD PMID:28903501
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP2D3 mRNA CTD PMID:19162173 NCBI chr 7:113,917,711...113,922,068 JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 decreases expression
increases expression
EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of CYP2F4 mRNA
Pregnenolone Carbonitrile results in decreased expression of CYP2F2 mRNA
Pregnenolone Carbonitrile results in increased expression of CYP2F1 mRNA
CTD PMID:15596064 PMID:19162173 PMID:27413110 NCBI chr 1:82,416,108...82,429,897
Ensembl chr 1:82,416,130...82,429,896
JBrowse link
G Cyp2j3 cytochrome P450, family 2, subfamily j, polypeptide 3 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP2J3 mRNA CTD PMID:19162173 NCBI chr 5:111,219,921...111,244,987 JBrowse link
G Cyp2u1 cytochrome P450, family 2, subfamily u, polypeptide 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CYP2U1 mRNA CTD PMID:28903501 NCBI chr 2:219,849,403...219,866,959
Ensembl chr 2:219,849,407...219,866,882
JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP3A18 mRNA CTD PMID:15596064 PMID:19162173 PMID:19850644 NCBI chr12:8,880,528...8,930,382
Ensembl chr12:8,880,528...8,930,381
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
increases activity
EXP
ISO
[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA; allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA]; Pregnenolone Carbonitrile results in increased expression of and results in increased activity of CYP3A2 protein
[Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 gene promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A4 protein]; NR3C1 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A4 mRNA]
Pregnenolone Carbonitrile results in increased expression of CYP3A4 mRNA; Pregnenolone Carbonitrile results in increased expression of CYP3A4 protein
Pregnenolone Carbonitrile results in increased expression of CYP3A2 mRNA; Pregnenolone Carbonitrile results in increased expression of CYP3A2 protein
Pregnenolone Carbonitrile results in increased activity of CYP3A2 protein
CTD PMID:10219967 PMID:12458634 PMID:12505310 PMID:15541768 PMID:15588932 More... NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases activity
increases expression
EXP [Dietary Fats co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A23-3A1 protein; Clofibrate promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 protein]; diphenyleneiodonium inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of CYP3A23-3A1 protein]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 mRNA]; perfluorodecanoic acid inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 protein]; Pregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to CYP3A23-3A1 promoter]
Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 mRNA; Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 protein
CTD PMID:9817075 PMID:10772642 PMID:11752103 PMID:12370413 PMID:12869653 More... NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression
multiple interactions
EXP
ISO
Pregnenolone Carbonitrile results in increased expression of CYP3A9 mRNA
Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA
trichostatin A inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]
Pregnenolone Carbonitrile results in increased expression of CYP3A13 mRNA
CTD PMID:15596064 PMID:19162173 PMID:19562681 PMID:19850644 PMID:20888898 More... NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP4A1 mRNA CTD PMID:19162173 PMID:29548889 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP4A2 mRNA CTD PMID:19162173 NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP4A3 mRNA CTD PMID:19162173 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP4B1 mRNA CTD PMID:15596064 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression
multiple interactions
ISO Pregnenolone Carbonitrile results in decreased expression of CYP4F14 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP4F14 mRNA]
CTD PMID:20359477 PMID:28903501 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP4F4 mRNA CTD PMID:15596064 NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506
JBrowse link
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP4F5 mRNA CTD PMID:19162173 NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978
JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CYP4V3 mRNA CTD PMID:28903501 NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions
EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of CYP7A1 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]
CTD PMID:15629111 PMID:19162173 PMID:20359477 PMID:22982774 PMID:27413110 More... NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP7B1 mRNA CTD PMID:19162173 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA] CTD PMID:20359477 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Daam1 dishevelled associated activator of morphogenesis 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DAAM1 mRNA CTD PMID:28903501 NCBI chr 6:90,389,544...90,550,114
Ensembl chr 6:90,389,688...90,550,114
JBrowse link
G Dact2 dishevelled-binding antagonist of beta-catenin 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of DACT2 mRNA CTD PMID:19162173 NCBI chr 1:55,181,023...55,191,026
Ensembl chr 1:55,181,024...55,191,096
JBrowse link
G Dancr differentiation antagonizing non-protein coding RNA increases expression ISO Pregnenolone Carbonitrile results in increased expression of DANCR mRNA CTD PMID:28903501 NCBI chr14:34,126,956...34,127,936 JBrowse link
G Dapk3 death-associated protein kinase 3 increases expression EXP Pregnenolone Carbonitrile results in increased expression of DAPK3 mRNA CTD PMID:19162173 NCBI chr 7:8,524,182...8,532,552
Ensembl chr 7:8,524,183...8,532,558
JBrowse link
G Dbndd1 dysbindin domain containing 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DBNDD1 mRNA CTD PMID:22698814 NCBI chr19:51,539,154...51,548,441
Ensembl chr19:51,539,148...51,548,444
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor decreases expression
increases expression
EXP
ISO
Pregnenolone Carbonitrile results in decreased expression of DBP mRNA
Pregnenolone Carbonitrile results in increased expression of DBP mRNA
CTD PMID:19162173 PMID:27413110 PMID:28903501 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
JBrowse link
G Dcaf11 DDB1 and CUL4 associated factor 11 increases expression EXP Pregnenolone Carbonitrile results in increased expression of DCAF11 mRNA CTD PMID:19162173 NCBI chr15:29,046,744...29,057,450
Ensembl chr15:29,046,826...29,057,669
JBrowse link
G Dcdc2 doublecortin domain containing 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DCDC2A mRNA CTD PMID:22698814 NCBI chr17:39,845,952...40,031,781
Ensembl chr17:39,845,952...40,030,743
JBrowse link
G Dcun1d4 defective in cullin neddylation 1 domain containing 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DCUN1D4 mRNA CTD PMID:28903501 NCBI chr14:34,652,723...34,733,122
Ensembl chr14:34,652,723...34,733,207
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DDAH1 mRNA CTD PMID:28903501 NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339
JBrowse link
G Ddc dopa decarboxylase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DDC mRNA CTD PMID:28903501 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DDIT4 mRNA CTD PMID:28903501 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Ddx21 DExD-box helicase 21 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DDX21 mRNA CTD PMID:28903501 NCBI chr20:30,534,319...30,554,513
Ensembl chr20:30,534,319...30,554,543
JBrowse link
G Ddx27 DEAD-box helicase 27 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DDX27 mRNA CTD PMID:28903501 NCBI chr 3:155,744,182...155,763,380
Ensembl chr 3:155,744,150...155,763,372
JBrowse link
G Dennd2b DENN domain containing 2B increases expression ISO Pregnenolone Carbonitrile results in increased expression of DENN2B mRNA CTD PMID:28903501 NCBI chr 1:163,544,075...163,734,736
Ensembl chr 1:163,544,074...163,694,680
JBrowse link
G Depdc7 DEP domain containing 7 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DEPDC7 mRNA CTD PMID:28903501 NCBI chr 3:91,099,111...91,121,152
Ensembl chr 3:91,099,835...91,121,124
JBrowse link
G Derl3 derlin 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DERL3 mRNA CTD PMID:28903501 NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027
JBrowse link
G Desi2 desumoylating isopeptidase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DESI2 mRNA CTD PMID:28903501 NCBI chr13:89,961,767...90,011,255
Ensembl chr13:89,961,934...90,016,416
JBrowse link
G Dexi Dexi homolog decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DEXI mRNA CTD PMID:28903501 NCBI chr10:5,126,021...5,138,746
Ensembl chr10:5,137,288...5,138,738
JBrowse link
G Dgkg diacylglycerol kinase, gamma increases expression EXP Pregnenolone Carbonitrile results in increased expression of DGKG mRNA CTD PMID:19162173 NCBI chr11:78,384,212...78,579,158
Ensembl chr11:78,384,458...78,577,212
JBrowse link
G Dgkz diacylglycerol kinase zeta decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of DGKZ mRNA CTD PMID:19162173 NCBI chr 3:77,904,149...77,946,114
Ensembl chr 3:77,904,150...77,946,099
JBrowse link
G Dhdh dihydrodiol dehydrogenase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DHDH mRNA CTD PMID:28903501 NCBI chr 1:95,954,361...95,965,262
Ensembl chr 1:95,953,092...95,965,197
JBrowse link
G Dhrs1 dehydrogenase/reductase 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DHRS1 mRNA CTD PMID:28903501 NCBI chr15:29,236,522...29,243,807
Ensembl chr15:29,236,522...29,243,838
JBrowse link
G Dhx36 DEAH-box helicase 36 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of DHX36 mRNA CTD PMID:19162173 NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of DIO1 mRNA CTD PMID:19162173 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease increases expression ISO Pregnenolone Carbonitrile results in increased expression of DIS3 mRNA CTD PMID:28903501 NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642
JBrowse link
G Dis3l2 DIS3-like 3'-5' exoribonuclease 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of DIS3L2 mRNA CTD PMID:19162173 NCBI chr 9:87,355,409...87,736,616
Ensembl chr 9:87,356,457...87,736,616
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase increases expression EXP
ISO
Pregnenolone Carbonitrile results in increased expression of DLAT mRNA CTD PMID:19162173 PMID:28903501 NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DLC1 mRNA CTD PMID:28903501 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439
JBrowse link
G Dll1 delta like canonical Notch ligand 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DLL1 mRNA CTD PMID:28903501 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase increases expression ISO Pregnenolone Carbonitrile results in increased expression of DLST mRNA CTD PMID:28903501 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
JBrowse link
G Dmac2l distal membrane arm assembly component 2 like increases expression EXP Pregnenolone Carbonitrile results in increased expression of DMAC2L mRNA CTD PMID:19162173 NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DNAJA3 mRNA CTD PMID:28903501 NCBI chr10:10,855,510...10,880,175
Ensembl chr10:10,854,732...10,880,161
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression EXP Pregnenolone Carbonitrile results in increased expression of DNAJB9 mRNA CTD PMID:19162173 PMID:21318169 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
JBrowse link
G Dnm3 dynamin 3 increases expression EXP Pregnenolone Carbonitrile results in increased expression of DNM3 mRNA CTD PMID:19162173 NCBI chr13:74,359,043...74,838,135
Ensembl chr13:74,359,213...74,838,108
JBrowse link
G Dop1a DOP1 leucine zipper like protein A increases expression ISO Pregnenolone Carbonitrile results in increased expression of DOP1A mRNA CTD PMID:28903501 NCBI chr 8:87,415,266...87,517,935
Ensembl chr 8:87,414,593...87,518,353
JBrowse link
G Dop1b DOP1 leucine zipper like protein B increases expression ISO Pregnenolone Carbonitrile results in increased expression of DOP1B mRNA CTD PMID:28903501 NCBI chr11:33,024,376...33,125,931
Ensembl chr11:33,024,411...33,125,931
JBrowse link
G Dpp9 dipeptidyl peptidase 9 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DPP9 mRNA CTD PMID:28903501 NCBI chr 9:1,011,347...1,046,337
Ensembl chr 9:1,011,351...1,046,541
JBrowse link
G Drg1 developmentally regulated GTP binding protein 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DRG1 mRNA CTD PMID:28903501 NCBI chr14:78,103,876...78,119,976
Ensembl chr14:78,103,876...78,119,953
JBrowse link
G Dsc2 desmocollin 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DSC2 mRNA CTD PMID:28903501 NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392
JBrowse link
G Dsg2 desmoglein 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DSG2 mRNA CTD PMID:28903501 NCBI chr18:11,846,207...11,904,630
Ensembl chr18:11,846,183...11,904,156
JBrowse link
G Dsp desmoplakin decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DSP mRNA CTD PMID:28903501 NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800
JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DTX4 mRNA CTD PMID:28903501 NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of DUSP1 mRNA CTD PMID:19162173 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp6 dual specificity phosphatase 6 affects expression EXP Pregnenolone Carbonitrile affects the expression of DUSP6 mRNA CTD PMID:19162173 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Dxo decapping exoribonuclease increases expression ISO Pregnenolone Carbonitrile results in increased expression of DXO mRNA CTD PMID:28903501 NCBI chr20:3,993,322...3,995,484
Ensembl chr20:3,993,327...3,995,494
JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of DYNC1H1 mRNA CTD PMID:19162173 NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
JBrowse link
G Dync2h1 dynein cytoplasmic 2 heavy chain 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of DYNC2H1 mRNA CTD PMID:19162173 NCBI chr 8:4,189,257...4,412,183
Ensembl chr 8:4,189,257...4,412,183
JBrowse link
G Dynll2 dynein light chain LC8-type 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DYNLL2 mRNA CTD PMID:28903501 NCBI chr10:72,767,035...72,785,824
Ensembl chr10:72,767,035...72,785,805
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of E2F1 mRNA CTD PMID:23626729 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G E2f2 E2F transcription factor 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of E2F2 mRNA CTD PMID:28903501 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G Ebna1bp2 EBNA1 binding protein 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of EBNA1BP2 mRNA CTD PMID:28903501 NCBI chr 5:132,148,164...132,152,730
Ensembl chr 5:132,148,143...132,153,267
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ECH1 mRNA CTD PMID:19162173 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Echdc3 enoyl CoA hydratase domain containing 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ECHDC3 mRNA CTD PMID:28903501 NCBI chr17:72,070,697...72,093,519
Ensembl chr17:72,070,668...72,093,516
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ECHS1 mRNA CTD PMID:19162173 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
JBrowse link
G Eef1b2 eukaryotic translation elongation factor 1 beta 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of EEF1B2 mRNA CTD PMID:28903501 NCBI chr 9:64,580,009...64,582,737
Ensembl chr 9:64,579,893...64,582,737
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of EEF2K mRNA CTD PMID:28903501 NCBI chr 1:175,393,119...175,454,452
Ensembl chr 1:175,393,154...175,455,164
JBrowse link
G Efna3 ephrin A3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of EFNA3 mRNA CTD PMID:28903501 NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736
JBrowse link
G Egfl7 EGF-like-domain, multiple 7 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of EGFL7 mRNA CTD PMID:19162173 NCBI chr 3:9,404,622...9,416,879
Ensembl chr 3:9,407,520...9,416,879
JBrowse link
G Egr1 early growth response 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of EGR1 mRNA CTD PMID:19162173 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr2 early growth response 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of EGR2 mRNA CTD PMID:22698814 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562