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G |
Ace |
angiotensin I converting enzyme |
affects response to substance |
ISO |
ACE gene polymorphism affects the susceptibility to Perindopril |
CTD |
PMID:11007831 |
|
NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
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G |
Ace2 |
angiotensin I converting enzyme 2 |
multiple interactions |
EXP |
Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of ACE2 mRNA]; Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of ACE2 protein] |
CTD |
PMID:19793108 |
|
NCBI chr X:32,050,734...32,095,860
Ensembl chr X:32,049,931...32,096,016
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G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression multiple interactions |
EXP |
Perindopril results in decreased expression of ACTA2 protein [Imatinib Mesylate co-treated with Perindopril] inhibits the reaction [Carbon Tetrachloride affects the expression of ACTA2 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of ACTA2 mRNA] |
CTD |
PMID:12076858 PMID:16596278 |
|
NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
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G |
Afp |
alpha-fetoprotein |
multiple interactions |
ISO |
Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] |
CTD |
PMID:29859236 |
|
NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
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G |
Agt |
angiotensinogen |
decreases expression increases expression multiple interactions |
ISO EXP |
Perindopril results in decreased expression of AGT protein alternative form Perindopril results in increased expression of AGT protein alternative form [Perindopril co-treated with racecadotril] results in increased expression of AGT protein alternative form |
CTD |
PMID:2549899 PMID:2605800 PMID:9808682 |
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NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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G |
Agtr1a |
angiotensin II receptor, type 1a |
affects response to substance multiple interactions |
ISO EXP |
AGTR1 gene SNP affects the susceptibility to Perindopril [Perindopril co-treated with AM6545] inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]; Perindopril inhibits the reaction [Streptozocin results in increased expression of AGTR1A mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein] Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A protein] |
CTD |
PMID:8952600 PMID:12930639 PMID:16097048 PMID:30184259 |
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NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
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G |
Alb |
albumin |
multiple interactions |
EXP ISO |
Perindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein] Perindopril inhibits the reaction [Streptozocin results in increased expression of ALB protein] |
CTD |
PMID:16872305 PMID:30184259 |
|
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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G |
Arg1 |
arginase 1 |
multiple interactions |
ISO |
Perindopril inhibits the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of ARG1 mRNA]] |
CTD |
PMID:30184259 |
|
NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
EXP |
Perindopril inhibits the reaction [Isoproterenol results in increased expression of BCL2L1 mRNA alternative form] |
CTD |
PMID:16116328 |
|
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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G |
Bdkrb1 |
bradykinin receptor B1 |
affects expression |
EXP |
Perindopril affects the expression of BDKRB1 protein |
CTD |
PMID:18806609 |
|
NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
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G |
Bdkrb2 |
bradykinin receptor B2 |
affects expression |
EXP |
Perindopril affects the expression of BDKRB2 protein |
CTD |
PMID:18806609 |
|
NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
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G |
Cat |
catalase |
increases activity |
EXP |
Perindopril results in increased activity of CAT protein |
CTD |
PMID:26878793 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression multiple interactions |
ISO |
Perindopril results in decreased expression of CCL2 protein [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCL2 protein] |
CTD |
PMID:19840533 PMID:30184259 |
|
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions |
ISO |
AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]] |
CTD |
PMID:30184259 |
|
NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
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|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] |
CTD |
PMID:29859236 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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G |
Ccr2 |
C-C motif chemokine receptor 2 |
multiple interactions |
ISO |
[AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCR2 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CCR2 mRNA] |
CTD |
PMID:30184259 |
|
|
|
G |
Cd163 |
CD163 molecule |
multiple interactions |
ISO |
AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]] |
CTD |
PMID:30184259 |
|
NCBI chr 4:156,752,063...156,785,467
Ensembl chr 4:156,752,082...156,785,467
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G |
Cd68 |
Cd68 molecule |
multiple interactions |
ISO |
AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]] |
CTD |
PMID:30184259 |
|
NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
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|
G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions |
EXP |
[Imatinib Mesylate co-treated with Perindopril] inhibits the reaction [Carbon Tetrachloride affects the expression of COL1A2 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of COL1A2 mRNA] |
CTD |
PMID:16596278 |
|
NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
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G |
Col3a1 |
collagen type III alpha 1 chain |
decreases expression |
EXP |
Perindopril results in decreased expression of COL3A1 mRNA |
CTD |
PMID:12076858 PMID:14871039 |
|
NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
[AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of FN1 protein] |
CTD |
PMID:30184259 |
|
NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
Perindopril inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein] |
CTD |
PMID:29859236 |
|
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]] |
CTD |
PMID:30184259 |
|
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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G |
Il10 |
interleukin 10 |
increases expression |
ISO |
Perindopril results in increased expression of IL10 protein |
CTD |
PMID:19840533 |
|
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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G |
Il1b |
interleukin 1 beta |
decreases expression |
ISO |
Perindopril results in decreased expression of IL1B protein |
CTD |
PMID:19840533 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il6 |
interleukin 6 |
decreases expression |
ISO |
Perindopril results in decreased expression of IL6 protein |
CTD |
PMID:19840533 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Kng2 |
kininogen 2 |
decreases expression increases expression multiple interactions |
ISO EXP |
Perindopril results in decreased expression of KNG1 protein modified form Perindopril results in increased expression of KNG1 protein alternative form Perindopril promotes the reaction [racecadotril affects the metabolism of KNG1 protein alternative form] |
CTD |
PMID:9808682 PMID:11855668 |
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NCBI chr11:81,509,185...81,516,759
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G |
Lep |
leptin |
decreases expression |
EXP |
Perindopril results in decreased expression of LEP protein |
CTD |
PMID:18083506 |
|
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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|
G |
Mas1 |
MAS1 proto-oncogene, G protein-coupled receptor |
multiple interactions |
EXP |
Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of MAS1 mRNA] |
CTD |
PMID:19793108 |
|
NCBI chr 1:48,076,761...48,108,218
Ensembl chr 1:48,077,033...48,108,216
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G |
Mfn2 |
mitofusin 2 |
increases expression |
EXP |
Perindopril results in increased expression of MFN2 mRNA; Perindopril results in increased expression of MFN2 protein |
CTD |
PMID:25464244 |
|
NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
EXP ISO |
Perindopril inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein] Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein] |
CTD |
PMID:12930639 PMID:14761280 PMID:16097048 PMID:29859236 |
|
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
Perindopril inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP9 protein] |
CTD |
PMID:16097048 |
|
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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|
G |
Mrc1 |
mannose receptor, C type 1 |
multiple interactions |
ISO |
AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]] |
CTD |
PMID:30184259 |
|
NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
Perindopril inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein] |
CTD |
PMID:29859236 |
|
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]] |
CTD |
PMID:30184259 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nphs1 |
NPHS1 adhesion molecule, nephrin |
multiple interactions |
ISO |
AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein]] |
CTD |
PMID:30184259 |
|
NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
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G |
Nphs2 |
NPHS2 stomatin family member, podocin |
multiple interactions |
ISO |
AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]] |
CTD |
PMID:30184259 |
|
NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
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G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions |
EXP |
Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein] |
CTD |
PMID:12930639 PMID:14761280 PMID:16097048 |
|
NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
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G |
Ppp3ca |
protein phosphatase 3 catalytic subunit alpha |
decreases expression |
EXP |
Perindopril results in decreased expression of PPP3CA protein |
CTD |
PMID:18344631 |
|
NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
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G |
Ppp3r1 |
protein phosphatase 3, regulatory subunit B, alpha |
decreases expression |
EXP |
Perindopril results in decreased expression of PPP3R1 mRNA |
CTD |
PMID:18344631 |
|
NCBI chr14:100,311,224...100,360,879
Ensembl chr14:100,311,173...100,360,879
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Perindopril inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein] |
CTD |
PMID:29859236 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Ren |
renin |
increases expression increases activity |
EXP ISO |
Perindopril results in increased expression of REN protein Perindopril results in increased activity of REN protein |
CTD |
PMID:2549899 PMID:2605800 PMID:9383173 |
|
NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
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G |
Ryr2 |
ryanodine receptor 2 |
multiple interactions increases expression |
EXP |
carvedilol promotes the reaction [Perindopril results in increased expression of RYR2 protein]; Perindopril promotes the reaction [carvedilol results in increased expression of RYR2 protein] |
CTD |
PMID:19620082 |
|
NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
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G |
Sfrp4 |
secreted frizzled-related protein 4 |
affects binding |
ISO |
Perindopril binds to SFRP4 protein |
CTD |
PMID:25019556 |
|
NCBI chr17:47,383,983...47,394,065
Ensembl chr17:47,297,489...47,394,328
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G |
Slc15a1 |
solute carrier family 15 member 1 |
multiple interactions |
ISO |
Perindopril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] |
CTD |
PMID:18713951 |
|
NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
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G |
Slc15a2 |
solute carrier family 15 member 2 |
multiple interactions |
EXP |
Perindopril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] |
CTD |
PMID:18713951 |
|
NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713
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G |
Smad3 |
SMAD family member 3 |
multiple interactions decreases expression |
EXP |
Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] Perindopril results in decreased expression of SMAD3 protein |
CTD |
PMID:15619341 PMID:16872305 |
|
NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
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G |
Smad7 |
SMAD family member 7 |
increases expression multiple interactions |
EXP |
Perindopril results in increased expression of SMAD7 protein Perindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein] |
CTD |
PMID:15619341 PMID:16872305 |
|
NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions decreases expression |
EXP ISO |
Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of TGFB1 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein] Perindopril results in decreased expression of TGFB1 mRNA; Perindopril results in decreased expression of TGFB1 protein |
CTD |
PMID:12930639 PMID:14761280 PMID:14871039 PMID:15619341 PMID:16097048 PMID:16596278 PMID:16872305 PMID:29859236 |
|
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Tgfbr2 |
transforming growth factor, beta receptor 2 |
decreases expression multiple interactions |
EXP |
Perindopril results in decreased expression of TGFBR2 mRNA Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA] |
CTD |
PMID:15619341 PMID:16872305 |
|
NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
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G |
Tnf |
tumor necrosis factor |
decreases expression multiple interactions increases expression |
ISO EXP |
Perindopril results in decreased expression of TNF protein AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]; Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of TNF protein]] Perindopril results in increased expression of TNF protein |
CTD |
PMID:19840533 PMID:26878793 PMID:29859236 PMID:30184259 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein] |
CTD |
PMID:29859236 |
|
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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|
G |
Vwf |
von Willebrand factor |
decreases expression |
ISO |
Perindopril results in decreased expression of VWF protein |
CTD |
PMID:12224817 |
|
NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
|
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