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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Nodularin
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Accession:CHEBI:80043 term browser browse the term
Definition:An ether that has formula C41H60N8O10.
Synonyms:related_synonym: Formula=C41H60N8O10;   InChI=1S/C41H60N8O10/c1-8-31-38(54)48-34(40(57)58)26(5)36(52)46-29(15-12-20-44-41(42)43)37(53)45-28(25(4)35(51)47-30(39(55)56)18-19-33(50)49(31)6)17-16-23(2)21-24(3)32(59-7)22-27-13-10-9-11-14-27/h8-11,13-14,16-17,21,24-26,28-30,32,34H,12,15,18-20,22H2,1-7H3,(H,45,53)(H,46,52)(H,47,51)(H,48,54)(H,55,56)(H,57,58)(H4,42,43,44)/b17-16+,23-21+,31-8-/t24-,25-,26-,28-,29-,30+,32-,34+/m0/s1;   InChIKey=IXBQSRWSVIBXNC-HSKGSTCASA-N;   SMILES=CO[C@@H](Cc1ccccc1)[C@@H](C)\\C=C(C)\\C=C\\[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](C)[C@@H](NC(=O)\\C(=C\\C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O
 xref: CAS:118399-22-7;   KEGG:C15713
 xref_mesh: MESH:C063998


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Nodularin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 increases activity EXP nodularin results in increased activity of ACOX1 protein CTD PMID:12112309 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO nodularin results in increased expression of ATF4 mRNA CTD PMID:27061667 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO nodularin results in increased expression of BCL2 mRNA CTD PMID:30562542 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP nodularin results in increased expression of BCL2L1 protein CTD PMID:25192816 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
increases expression		 EXP
ISO		 nodularin results in increased activity of CASP8 protein
sauchinone inhibits the reaction [nodularin results in increased expression of CASP8 mRNA]		 CTD PMID:25192816 PMID:27061667 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity EXP nodularin results in increased activity of CASP9 protein CTD PMID:25192816 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO nodularin results in decreased expression of CDKN1A mRNA CTD PMID:30562542 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP [nodularin co-treated with Diethylnitrosamine] results in decreased activity of CYP11A1 protein CTD PMID:12112309 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP [nodularin co-treated with Diethylnitrosamine] results in decreased activity of CYP17A1 protein CTD PMID:12112309 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO nodularin results in increased expression of DDIT3 mRNA; nodularin results in increased expression of DDIT3 protein CTD PMID:27061667 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions		 ISO nodularin results in increased expression of FAS mRNA; nodularin results in increased expression of FAS protein
RELA mutant form inhibits the reaction [nodularin results in increased expression of FAS mRNA]; RELA mutant form inhibits the reaction [nodularin results in increased expression of FAS protein]		 CTD PMID:21262250 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression
multiple interactions		 ISO nodularin results in increased expression of FASLG mRNA; nodularin results in increased expression of FASLG protein
RELA mutant form inhibits the reaction [nodularin results in increased expression of FASLG mRNA]; RELA mutant form inhibits the reaction [nodularin results in increased expression of FASLG protein]		 CTD PMID:21262250 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO sauchinone inhibits the reaction [nodularin results in increased expression of FOS mRNA] CTD PMID:27061667 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO nodularin results in increased expression of FOSL1 mRNA
sauchinone inhibits the reaction [nodularin results in increased expression of FOSL1 mRNA]		 CTD PMID:27061667 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression ISO nodularin affects the expression of GADD45A mRNA CTD PMID:30562542 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects expression ISO nodularin affects the expression of GCLC mRNA CTD PMID:30562542 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpx1 glutathione peroxidase 1 affects expression ISO nodularin affects the expression of GPX1 mRNA CTD PMID:30562542 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO nodularin results in increased expression of HSPA5 mRNA CTD PMID:27061667 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO nodularin results in increased expression of JUN mRNA CTD PMID:27061667 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO nodularin results in increased expression of JUND mRNA
sauchinone inhibits the reaction [nodularin results in increased expression of JUND mRNA]		 CTD PMID:27061667 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP nodularin results in increased phosphorylation of MAPK1 protein CTD PMID:25192816 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP nodularin results in increased phosphorylation of MAPK3 protein CTD PMID:25192816 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO nodularin results in increased expression of MDM2 mRNA CTD PMID:30562542 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO nodularin results in increased expression of MYC mRNA CTD PMID:27061667 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO nodularin results in increased expression of PPP1R15A mRNA CTD PMID:27061667 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases localization		 ISO RELA mutant form inhibits the reaction [nodularin results in increased expression of FAS mRNA]; RELA mutant form inhibits the reaction [nodularin results in increased expression of FAS protein]; RELA mutant form inhibits the reaction [nodularin results in increased expression of FASLG mRNA]; RELA mutant form inhibits the reaction [nodularin results in increased expression of FASLG protein]
nodularin results in increased localization of RELA protein		 CTD PMID:21262250 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 increases phosphorylation EXP nodularin results in increased phosphorylation of RPS6KA1 protein CTD PMID:25192816 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation EXP nodularin results in increased phosphorylation of RPS6KB1 protein; nodularin results in increased phosphorylation of RPS6KB1 protein alternative form CTD PMID:25192816 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion		 ISO
EXP		 nodularin results in increased expression of TNF mRNA
sauchinone inhibits the reaction [nodularin results in increased expression of TNF mRNA]; sauchinone inhibits the reaction [nodularin results in increased secretion of TNF protein]
Nodularin results in the increased expression of Tnf mRNA and protein		 CTD
RGD		 PMID:27061667 PMID:9292703 RGD:14994704 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO nodularin results in increased expression of XBP1 mRNA alternative form CTD PMID:27061667 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      atom 19809
        nonmetal atom 19747
          oxygen atom 19520
            oxygen molecular entity 19490
              organooxygen compound 19137
                ether 17284
                  Nodularin 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  ether 17284
                                    Nodularin 30
paths to the root