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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:GW 1929
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Accession:CHEBI:79992 term browser browse the term
Definition:A benzophenone that has formula C30H29N3O4.
Synonyms:related_synonym: Formula=C30H29N3O4;   InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1;   InChIKey=QTQMRBZOBKYXCG-MHZLTWQESA-N;   SMILES=CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)c1ccccn1
 alt_id: MESH:C120099
 xref: CAS:196808-24-9;   KEGG:C15626
 xref_mesh: MESH:C120099



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GW 1929 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C6h14orf28  similar to human chromosome 14 open reading frame 28 multiple interactions ISO GW 1929 promotes the reaction [C14ORF28 protein binds to PPARG protein] CTD PMID:32407875 NCBI chr 6:82,965,304...82,973,942
Ensembl chr 6:82,965,328...82,972,558
JBrowse link
G Casp3 caspase 3 multiple interactions ISO GW 1929 inhibits the reaction [tetrabromobisphenol A results in increased activity of CASP3 protein] CTD PMID:24132472 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases response to substance ISO GW 1929 results in decreased susceptibility to CCL5 protein CTD PMID:18158351 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO GW 1929 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CREB1 protein]; GW 1929 inhibits the reaction [VEGFA protein results in increased phosphorylation of CREB1 protein] CTD PMID:20032081 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases response to substance
multiple interactions
ISO GW 1929 results in decreased susceptibility to CXCL12 protein
GW 1929 inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]
CTD PMID:18158351 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Efna1 ephrin A1 increases expression
multiple interactions
EXP GW 1929 results in increased expression of EFNA1 mRNA
Mercaptopurine promotes the reaction [GW 1929 results in increased expression of EFNA1 mRNA]
CTD PMID:27435855 NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO [GW 1929 binds to and results in increased activity of PPARG protein] promotes the reaction [TNF protein results in decreased susceptibility to FSHB protein] CTD PMID:21734263 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 decreases expression EXP GW 1929 results in decreased expression of GRK2 mRNA CTD PMID:19420904 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Ifng interferon gamma multiple interactions ISO GW 1929 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; GW 1929 inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA]; GW 1929 inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA] CTD PMID:12847270 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO GW 1929 inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA] CTD PMID:12847270 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK1 protein] CTD PMID:12083801 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK3 protein] CTD PMID:12083801 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO GW 1929 promotes the reaction [NCOA2 protein binds to PPARG protein] CTD PMID:32407875 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Ncoa6 nuclear receptor coactivator 6 multiple interactions ISO GW 1929 promotes the reaction [NCOA6 protein binds to PPARG protein] CTD PMID:32407875 NCBI chr 3:143,890,896...143,961,916
Ensembl chr 3:143,890,896...143,952,268
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO GW 1929 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; GW 1929 inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA] CTD PMID:12847270 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions
affects localization
EXP [GW 1929 co-treated with Mercaptopurine] results in increased expression of NR4A2 mRNA; [GW 1929 co-treated with Mercaptopurine] results in increased expression of NR4A2 protein
GW 1929 affects the localization of NR4A2 protein
CTD PMID:27435855 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO GW 1929 promotes the reaction [NRIP1 protein binds to PPARG protein] CTD PMID:32407875 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
affects binding
multiple interactions
increases expression
ISO
EXP
GW 1929 results in increased activity of PPARG protein
GW 1929 binds to PPARG protein
[GW 1929 binds to and results in increased activity of PPARG protein] promotes the reaction [TNF protein results in decreased susceptibility to FSHB protein]; butylbenzyl phthalate inhibits the reaction [GW 1929 binds to PPARG protein]; GW 1929 inhibits the reaction [GW 1929 binds to PPARG protein]; GW 1929 inhibits the reaction [Melatonin results in increased expression of PPARG protein]; GW 1929 inhibits the reaction [Pioglitazone results in increased expression of PPARG protein]; GW 1929 promotes the reaction [C14ORF28 protein binds to PPARG protein]; GW 1929 promotes the reaction [NCOA2 protein binds to PPARG protein]; GW 1929 promotes the reaction [NCOA6 protein binds to PPARG protein]; GW 1929 promotes the reaction [NRIP1 protein binds to PPARG protein]; GW 1929 promotes the reaction [PPARGC1A protein binds to PPARG protein]; GW 1929 results in increased activity of [PPARG protein binds to RXRA protein]; Pioglitazone inhibits the reaction [GW 1929 binds to PPARG protein]; tributyltin inhibits the reaction [GW 1929 binds to PPARG protein]; ZNF366 protein promotes the reaction [GW 1929 results in increased activity of [PPARG protein binds to RXRA protein]]
GW 1929 results in increased expression of PPARG mRNA
4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW 1929 results in increased expression of PPARG mRNA]; GW 1929 binds to and results in increased activity of PPARG protein; GW 1929 inhibits the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; GW 1929 inhibits the reaction [tetrabromobisphenol A results in decreased expression of PPARG protein]
CTD PMID:12847270 PMID:18292206 PMID:19420904 PMID:20008677 PMID:20516370 More... NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO GW 1929 promotes the reaction [PPARGC1A protein binds to PPARG protein] CTD PMID:32407875 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prnp prion protein multiple interactions ISO GW 1929 inhibits the reaction [Melatonin results in increased expression of PRNP protein]; GW 1929 inhibits the reaction [Pioglitazone results in increased expression of PRNP protein] CTD PMID:29734669 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO GW 1929 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of PTGS2 protein]; GW 1929 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; GW 1929 inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of PTGS2 protein]; GW 1929 inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA] CTD PMID:20032081 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases activity ISO GW 1929 results in increased activity of RAF1 protein CTD PMID:12083801 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO GW 1929 results in increased activity of [PPARG protein binds to RXRA protein]; ZNF366 protein promotes the reaction [GW 1929 results in increased activity of [PPARG protein binds to RXRA protein]] CTD PMID:20008677 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP [GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]; GW 1929 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:27435855 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [GW 1929 binds to and results in increased activity of PPARG protein] promotes the reaction [TNF protein results in decreased susceptibility to FSHB protein] CTD PMID:21734263 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO GW 1929 inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of PTGS2 protein]; GW 1929 inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; GW 1929 inhibits the reaction [VEGFA protein results in increased phosphorylation of CREB1 protein] CTD PMID:20032081 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Zfp366 zinc finger protein 366 multiple interactions ISO ZNF366 protein promotes the reaction [GW 1929 results in increased activity of [PPARG protein binds to RXRA protein]] CTD PMID:20008677 NCBI chr 2:30,578,552...30,640,546
Ensembl chr 2:30,578,715...30,642,182
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    chemical entity 19832
      group 19791
        inorganic group 19383
          oxo group 18879
            organic oxo compound 18879
              carbonyl compound 18879
                ketone 17180
                  aromatic ketone 12448
                    benzophenones 1283
                      GW 1929 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19730
                        carbon atom 19727
                          organic molecular entity 19727
                            organic group 18947
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18879
                                    carbonyl compound 18879
                                      ketone 17180
                                        aromatic ketone 12448
                                          benzophenones 1283
                                            GW 1929 27
paths to the root