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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pentobarbital
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Accession:CHEBI:7983 term browser browse the term
Definition:A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Synonyms:exact_synonym: 5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
 related_synonym: 5-Ethyl-5-(1-methyl-butyl)-pyrimidine-2,4,6-trione;   5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione;   5-ethyl-5-(1-methylbutyl)barbituric acid;   5-ethyl-5-(sec-pentyl)barbituric acid;   Formula=C11H18N2O3;   InChI=1S/C11H18N2O3/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);   InChIKey=WEXRUCMBJFQVBZ-UHFFFAOYSA-N;   Nembutal;   Pentobarbitone;   SMILES=CCCC(C)C1(CC)C(=O)NC(=O)NC1=O
 alt_id: CHEBI:102327
 xref: Beilstein:87067;   CAS:76-74-4;   DrugBank:DB00312;   Drug_Central:2095;   Gmelin:281792;   HMDB:HMDB0014457;   KEGG:C07422;   KEGG:D00499;   LINCS:LSM-1566
 xref_mesh: MESH:D010424
 xref: PMID:15324906;   PMID:15801854;   PMID:15857133;   PMID:16720246;   PMID:1977910;   PMID:19879734;   PMID:2215478;   PMID:23246494;   PMID:23345614;   PMID:23526799;   PMID:23663566;   PMID:2579237;   PMID:3599019;   PMID:3654008;   PMID:6864729;   PMID:7154009;   PMID:9016329;   PMID:9412440;   PMID:9599235;   Reaxys:87067;   VSDB:3000;   Wikipedia:Pentobarbital


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pentobarbital term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO ABCB1A protein affects the susceptibility to [Pentobarbital co-treated with Cyclosporine]; ABCB1A protein affects the susceptibility to [Pentobarbital co-treated with Ketamine] CTD PMID:17959987 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Pentobarbital results in decreased activity of and results in decreased phosphorylation of AKT1 protein CTD PMID:19346066 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression EXP Pentobarbital results in decreased expression of APAF1 mRNA CTD PMID:16978161 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G App amyloid beta precursor protein affects expression
multiple interactions		 EXP Pentobarbital affects the expression of APP mRNA
Pentobarbital inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA]		 CTD PMID:1306490 PMID:9720974 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bcl10 BCL10, immune signaling adaptor decreases expression EXP Pentobarbital results in decreased expression of BCL10 mRNA CTD PMID:16978161 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Pentobarbital results in increased expression of BCL2 CTD PMID:17715682 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression		 EXP [Diazepam co-treated with Pentobarbital] promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; [Pilocarpine co-treated with Diazepam co-treated with Pentobarbital] results in increased expression of BDNF protein; Pentobarbital inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]
Pentobarbital results in decreased expression of BDNF mRNA		 CTD PMID:8247360 PMID:8405262 PMID:11259499 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase decreases expression EXP Pentobarbital results in decreased expression of BLK mRNA CTD PMID:16978161 NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Pentobarbital results in increased expression of BNIP3 mRNA CTD PMID:16978161 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Pentobarbital CTD PMID:15644869 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688 		JBrowse link
G Casp14 caspase 14 decreases expression EXP Pentobarbital results in decreased expression of CASP14 mRNA CTD PMID:16978161 NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405 		JBrowse link
G Casp7 caspase 7 increases expression EXP Pentobarbital results in increased expression of CASP7 mRNA CTD PMID:16978161 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 decreases expression EXP Pentobarbital results in decreased expression of CASP8 mRNA CTD PMID:16978161 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Pentobarbital results in decreased expression of CCND1 protein CTD PMID:19346066 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd3 cyclin D3 decreases expression EXP Pentobarbital results in decreased expression of CCND3 protein CTD PMID:19346066 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Cd27 CD27 molecule decreases expression EXP Pentobarbital results in decreased expression of CD27 mRNA CTD PMID:16978161 NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592 		JBrowse link
G Cd40lg CD40 ligand decreases expression EXP Pentobarbital results in decreased expression of CD40LG mRNA CTD PMID:16978161 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression EXP Pentobarbital results in decreased expression of CDK2 protein CTD PMID:19346066 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression EXP Pentobarbital results in decreased expression of CDKN1A mRNA CTD PMID:16978161 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chek2 checkpoint kinase 2 increases expression EXP Pentobarbital results in increased expression of CHEK2 mRNA CTD PMID:16978161 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance ISO CNR1 protein affects the susceptibility to Pentobarbital CTD PMID:17442049 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain increases expression EXP Pentobarbital results in increased expression of CRADD mRNA CTD PMID:16978161 NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907 		JBrowse link
G Crh corticotropin releasing hormone affects expression EXP Pentobarbital affects the expression of CRH mRNA CTD PMID:18819432 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions EXP Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein]; Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA] CTD PMID:12093084 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Pentobarbital results in increased expression of CYP1A2 mRNA CTD PMID:10064569 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Pentobarbital results in increased expression of CYP2B1 mRNA; Pentobarbital results in increased expression of CYP2B1 protein CTD PMID:8205533 PMID:15655285 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Pentobarbital results in increased expression of CYP2B2 mRNA CTD PMID:15655285 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha decreases expression EXP Pentobarbital results in decreased expression of DFFA mRNA CTD PMID:16978161 NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO [Haloperidol results in increased expression of DRD2 protein] which results in decreased susceptibility to Pentobarbital CTD PMID:2945998 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Faslg Fas ligand decreases expression EXP Pentobarbital results in decreased expression of FASLG mRNA CTD PMID:16978161 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Folh1 folate hydrolase 1 increases response to substance ISO FOLH1 protein results in increased susceptibility to Pentobarbital CTD PMID:15387974 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
affects expression
decreases expression
increases expression		 ISO
EXP		 Pentobarbital inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]
Pentobarbital affects the expression of FOS mRNA
Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; Pentobarbital promotes the reaction [Naloxone results in increased expression of FOS protein]
Pentobarbital affects the expression of FOS protein
Pentobarbital results in decreased expression of FOS mRNA; Pentobarbital results in decreased expression of FOS protein
Pentobarbital results in increased expression of FOS mRNA; Pentobarbital results in increased expression of FOS protein		 CTD PMID:1527597 PMID:2114646 PMID:2176705 PMID:3037702 PMID:3427445 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression
multiple interactions		 EXP Pentobarbital results in decreased expression of FSHB protein
Pentobarbital inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of FSHB protein]		 CTD PMID:12606454 PMID:17638707 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Fst follistatin multiple interactions EXP Pentobarbital inhibits the reaction [Estrogens results in increased expression of FST mRNA] CTD PMID:8612495 NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
affects expression
decreases expression		 ISO
EXP		 [Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]; Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]
Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
Pentobarbital affects the expression of GABRA1 mRNA
Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA1 protein]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Pentobarbital results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB1 protein]
Pentobarbital results in decreased expression of GABRA1 mRNA		 CTD PMID:1712603 PMID:1977069 PMID:2165521 PMID:8207435 PMID:8397295 More... NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 affects response to substance
multiple interactions		 ISO
EXP		 GABRA2 protein affects the susceptibility to Pentobarbital
Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA2 protein]		 CTD PMID:8397295 PMID:18313124 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression ISO Pentobarbital results in increased expression of GABRA4 mRNA CTD PMID:16733821 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 increases expression EXP Pentobarbital results in increased expression of GABRA6 mRNA CTD PMID:8787126 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions
increases expression		 ISO
EXP		 Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]
Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]; Pentobarbital results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB1 protein]
Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
Pentobarbital results in increased expression of GABRB1 mRNA		 CTD PMID:1712603 PMID:1977069 PMID:2165521 PMID:9661255 PMID:10049148 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance
multiple interactions
affects expression		 EXP GABRB2 protein affects the susceptibility to Pentobarbital
Pentobarbital affects the reaction [GABRB2 protein binds to Muscimol]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentobarbital promotes the reaction [Muscimol binds to GABRB2 protein]; Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
Pentobarbital affects the expression of GABRB2 mRNA		 CTD PMID:8397295 PMID:10591412 PMID:12939268 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions EXP
ISO		 Pentobarbital promotes the reaction [Muscimol binds to GABRB3 protein]
[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]		 CTD PMID:8397295 PMID:9316872 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta affects response to substance
increases expression		 ISO GABRD protein affects the susceptibility to Pentobarbital
Pentobarbital results in increased expression of GABRD mRNA		 CTD PMID:8848253 PMID:15201633 NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411 		JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon multiple interactions
decreases response to substance		 ISO
EXP		 Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]
GABRE protein results in decreased susceptibility to Pentobarbital		 CTD PMID:9039914 PMID:10049148 NCBI chr  X:150,060,035...150,078,773
Ensembl chr  X:150,060,040...150,078,693 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
affects expression
decreases expression		 ISO
EXP		 [Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]; Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Pentobarbital results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]; Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]
Pentobarbital affects the expression of GABRG2 mRNA
Pentobarbital results in decreased expression of GABRG2 mRNA
Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; Pentobarbital results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB1 protein]		 CTD PMID:1712603 PMID:2165521 PMID:8412506 PMID:8787126 PMID:9316872 More... NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gal galanin and GMAP prepropeptide decreases expression
multiple interactions		 EXP Pentobarbital results in decreased expression of GAL mRNA
Pentobarbital inhibits the reaction [[Estrogens co-treated with Progesterone] results in increased expression of GAL mRNA]		 CTD PMID:7512492 PMID:7537244 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gap43 growth associated protein 43 multiple interactions EXP Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA] CTD PMID:8774942 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gast gastrin multiple interactions EXP Pentobarbital inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:10864877 PMID:12190085 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions EXP [Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein; Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein] CTD PMID:16959836 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP Pentobarbital results in decreased expression of GJB1 protein CTD PMID:8205533 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925 		JBrowse link
G Gnai1 G protein subunit alpha i1 affects expression EXP Pentobarbital affects the expression of GNAI1 mRNA CTD PMID:12199159 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnao1 G protein subunit alpha o1 affects expression EXP Pentobarbital affects the expression of GNAO1 mRNA CTD PMID:12199159 NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493 		JBrowse link
G Gnas GNAS complex locus affects expression EXP Pentobarbital affects the expression of GNAS mRNA CTD PMID:12199159 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Gnrhr gonadotropin releasing hormone receptor decreases expression EXP Pentobarbital results in decreased expression of GNRHR mRNA CTD PMID:7867555 NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 affects response to substance ISO GRIA2 protein affects the susceptibility to Pentobarbital CTD PMID:10551584 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 affects expression EXP Pentobarbital affects the expression of GRIN1 mRNA CTD PMID:10717408 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects response to substance
affects expression		 ISO
EXP		 GRIN2A protein affects the susceptibility to Pentobarbital
Pentobarbital affects the expression of GRIN2A mRNA		 CTD PMID:9814547 PMID:15731593 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B affects expression EXP Pentobarbital affects the expression of GRIN2B mRNA CTD PMID:9814547 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C affects expression EXP Pentobarbital affects the expression of GRIN2C mRNA CTD PMID:9814547 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427 		JBrowse link
G Hcrtr1 hypocretin receptor 1 decreases expression EXP Pentobarbital results in decreased expression of HCRTR1 mRNA CTD PMID:17638707 NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:142,477,214...142,486,674 		JBrowse link
G Hcrtr2 hypocretin receptor 2 decreases expression EXP Pentobarbital results in decreased expression of HCRTR2 mRNA CTD PMID:17638707 NCBI chr 8:76,989,834...77,105,953
Ensembl chr 8:76,989,834...77,105,893 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions EXP Pentobarbital inhibits the reaction [Arginine Vasopressin results in increased expression of HSPB1 mRNA]; Pentobarbital inhibits the reaction [Arginine Vasopressin results in increased expression of HSPB1 protein]; Pentobarbital inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HSPB1 protein] CTD PMID:10839933 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Pentobarbital results in increased expression of ICAM1 mRNA CTD PMID:17414419 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO
EXP		 Pentobarbital results in increased expression of IL1B mRNA
Ozone promotes the reaction [Pentobarbital results in increased expression of IL1B mRNA]		 CTD PMID:15207037 PMID:15207038 PMID:17414419 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression ISO
EXP		 Pentobarbital results in increased expression of IL6 protein
Pentobarbital results in increased expression of IL6 mRNA		 CTD PMID:15207037 PMID:15207038 PMID:17414419 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgae integrin subunit alpha E increases expression EXP Pentobarbital results in increased expression of ITGAE mRNA CTD PMID:28717108 NCBI chr10:57,704,813...57,764,093
Ensembl chr10:57,591,753...57,764,093
Ensembl chr10:57,591,753...57,764,093 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
affects expression
decreases activity
decreases expression		 ISO
EXP		 Pentobarbital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN mRNA]
Pentobarbital affects the expression of JUN mRNA
Pentobarbital inhibits the reaction [Lipopolysaccharides results in increased activity of JUN protein]
Pentobarbital results in decreased activity of JUN protein
Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; Pentobarbital results in decreased activity of and results in decreased phosphorylation of JUN protein
Pentobarbital results in decreased expression of JUN protein		 CTD PMID:1572316 PMID:8417141 PMID:8510500 PMID:9332719 PMID:10781476 More... NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Pentobarbital results in decreased expression of JUNB protein CTD PMID:8510500 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Pentobarbital results in decreased expression of JUND protein CTD PMID:8510500 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 decreases activity ISO Pentobarbital results in decreased activity of KCNE1 protein CTD PMID:11862331 NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Pentobarbital results in decreased activity of KCNH2 protein CTD PMID:11862331 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Pentobarbital inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of KRAS protein] CTD PMID:15263067 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions
decreases expression		 EXP Pentobarbital inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of LHB protein]
Pentobarbital results in decreased expression of LHB protein		 CTD PMID:12606454 PMID:17638707 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Ltbr lymphotoxin beta receptor decreases expression EXP Pentobarbital results in decreased expression of LTBR mRNA CTD PMID:16978161 NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO
EXP		 Pentobarbital results in decreased phosphorylation of MAPK1 protein
Pentobarbital results in decreased activity of and results in decreased phosphorylation of MAPK1 protein		 CTD PMID:15263067 PMID:19346066 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO
EXP		 Pentobarbital results in decreased phosphorylation of MAPK3 protein
Pentobarbital results in decreased activity of and results in decreased phosphorylation of MAPK3 protein		 CTD PMID:15263067 PMID:19346066 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP Pentobarbital results in decreased expression of MCL1 mRNA CTD PMID:16978161 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO MED1 protein affects the localization of [Pentobarbital binds to NR1I3 protein] CTD PMID:16828057 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Mpo myeloperoxidase increases activity EXP Pentobarbital results in increased activity of MPO protein CTD PMID:15564938 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression EXP Pentobarbital results in increased expression of MYD88 mRNA CTD PMID:16978161 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nppa natriuretic peptide A decreases expression EXP Pentobarbital results in decreased expression of NPPA protein CTD PMID:8464334 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Npy neuropeptide Y increases response to substance
multiple interactions		 ISO NPY protein results in increased susceptibility to Pentobarbital
NPY1R protein affects the reaction [NPY protein results in increased susceptibility to Pentobarbital]		 CTD PMID:11454027 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 multiple interactions
increases response to substance		 ISO NPY1R protein affects the reaction [NPY protein results in increased susceptibility to Pentobarbital]
NPY1R protein results in increased susceptibility to Pentobarbital		 CTD PMID:11454027 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Pentobarbital binds to and results in increased activity of NR1I2 protein CTD PMID:15039302 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
affects binding		 ISO MED1 protein affects the localization of [Pentobarbital binds to NR1I3 protein] CTD PMID:16828057 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions
decreases expression		 EXP Chorionic Gonadotropin inhibits the reaction [Pentobarbital results in decreased expression of NR4A1 mRNA] CTD PMID:11416027 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 decreases expression EXP Pentobarbital results in decreased expression of NTRK3 mRNA CTD PMID:9191102 NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286 		JBrowse link
G Obp3 alpha-2u globulin PGCL4 increases expression EXP Pentobarbital results in increased expression of OBP3 mRNA CTD PMID:28717108 NCBI chr 5:74,842,316...74,845,858
Ensembl chr 5:74,842,316...74,845,757 		JBrowse link
G Pdyn prodynorphin multiple interactions EXP Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA] CTD PMID:8417141 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin multiple interactions EXP Pentobarbital inhibits the reaction [Estradiol results in increased expression of PENK mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA] CTD PMID:8417141 PMID:8717366 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pgr progesterone receptor decreases expression EXP Pentobarbital results in decreased expression of PGR mRNA CTD PMID:1840636 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pomc proopiomelanocortin multiple interactions
decreases expression		 EXP Muscimol promotes the reaction [Pentobarbital results in decreased expression of POMC mRNA]; Pentobarbital inhibits the reaction [Acetylcholine results in increased expression of POMC protein] CTD PMID:7588217 PMID:7937335 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Por cytochrome p450 oxidoreductase increases export
increases metabolic processing
affects response to substance		 ISO POR protein results in increased export of Pentobarbital
POR protein results in increased metabolism of Pentobarbital
POR protein affects the susceptibility to Pentobarbital		 CTD PMID:12566435 PMID:12697746 PMID:15328377 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Prl prolactin decreases expression EXP Pentobarbital results in decreased expression of PRL protein CTD PMID:17638707 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Pentobarbital inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of RAC1 protein] CTD PMID:15263067 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression EXP Pentobarbital results in decreased expression of RB1 protein modified form CTD PMID:19346066 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Ren renin increases activity EXP Pentobarbital results in increased activity of REN protein CTD PMID:3512818 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slc13a3 solute carrier family 13 member 3 increases expression EXP Pentobarbital results in increased expression of SLC13A3 mRNA CTD PMID:28717108 NCBI chr 3:154,141,878...154,204,604
Ensembl chr 3:154,141,872...154,204,606 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases activity		 ISO Pentobarbital inhibits the reaction [SLC2A1 protein results in increased uptake of 3-O-Methylglucose]; Pentobarbital promotes the reaction [SLC2A1 gene polymorphism results in decreased uptake of 3-O-Methylglucose]
Pentobarbital results in decreased activity of SLC2A1 protein		 CTD PMID:10590023 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions
increases expression		 ISO Chorionic Gonadotropin inhibits the reaction [Pentobarbital results in increased expression of SUMO1 protein]; Pentobarbital inhibits the reaction [Gonadotropins results in decreased expression of SUMO1 protein] CTD PMID:14500579 NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761 		JBrowse link
G Tnf tumor necrosis factor decreases activity
multiple interactions
increases expression		 ISO
EXP		 Pentobarbital results in decreased activity of TNF protein
Pentobarbital inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Pentobarbital inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Pentobarbital results in increased expression of TNF mRNA; Pentobarbital results in increased expression of TNF protein		 CTD PMID:17414419 PMID:17545946 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b decreases expression EXP Pentobarbital results in decreased expression of TNFRSF10B mRNA CTD PMID:16978161 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A decreases expression EXP Pentobarbital results in decreased expression of TNFRSF11A mRNA CTD PMID:16978161 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression EXP Pentobarbital results in increased expression of TNFRSF11B mRNA CTD PMID:16978161 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression EXP Pentobarbital results in decreased expression of TNFRSF1A mRNA CTD PMID:16978161 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression EXP Pentobarbital results in decreased expression of TNFSF11 mRNA CTD PMID:16978161 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tnfsf12 TNF superfamily member 12 decreases expression EXP Pentobarbital results in decreased expression of TNFSF12 mRNA CTD PMID:16978161 NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213 		JBrowse link
G Tnfsf13 TNF superfamily member 13 decreases expression EXP Pentobarbital results in decreased expression of TNFSF13 mRNA CTD PMID:16978161 NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042 		JBrowse link
G Tnfsf14 TNF superfamily member 14 decreases expression EXP Pentobarbital results in decreased expression of TNFSF14 mRNA CTD PMID:16978161 NCBI chr 9:2,068,295...2,073,128
Ensembl chr 9:2,069,104...2,073,216 		JBrowse link
G Tnfsf4 TNF superfamily member 4 decreases expression EXP Pentobarbital results in decreased expression of TNFSF4 mRNA CTD PMID:16978161 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 decreases expression EXP Pentobarbital results in decreased expression of TRAF2 mRNA CTD PMID:16978161 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Traf3 Tnf receptor-associated factor 3 decreases expression EXP Pentobarbital results in decreased expression of TRAF3 mRNA CTD PMID:16978161 NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481 		JBrowse link
G Upp1 uridine phosphorylase 1 affects response to substance
multiple interactions		 ISO UPP1 protein affects the susceptibility to Pentobarbital
[UPP1 protein results in increased metabolism of Uridine] which affects the susceptibility to Pentobarbital		 CTD PMID:15772079 NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression EXP Pentobarbital results in decreased expression of XIAP mRNA CTD PMID:16978161 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        biophysical role 14060
          membrane transport modulator 13902
            GABA modulator 5115
              barbiturates 4636
                pentobarbital 113
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organic heteromonocyclic compound 17794
                                    diazines 13228
                                      pyrimidines 13094
                                        pyrimidone 10509
                                          barbiturates 4636
                                            pentobarbital 113
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