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ONTOLOGY REPORT - ANNOTATIONS


Term:pentobarbital
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Accession:CHEBI:7983 term browser browse the term
Definition:A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Synonyms:exact_synonym: 5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
 related_synonym: 5-Ethyl-5-(1-methyl-butyl)-pyrimidine-2,4,6-trione;   5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione;   5-ethyl-5-(1-methylbutyl)barbituric acid;   5-ethyl-5-(sec-pentyl)barbituric acid;   Formula=C11H18N2O3;   InChI=1S/C11H18N2O3/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);   InChIKey=WEXRUCMBJFQVBZ-UHFFFAOYSA-N;   Nembutal;   Pentobarbitone;   SMILES=CCCC(C)C1(CC)C(=O)NC(=O)NC1=O
 alt_id: CHEBI:102327
 xref: Beilstein:87067 "Beilstein";   CAS:76-74-4 "ChemIDplus";   CAS:76-74-4 "KEGG COMPOUND";   CAS:76-74-4 "NIST Chemistry WebBook";   DrugBank:DB00312;   Drug_Central:2095 "DrugCentral";   Gmelin:281792 "Gmelin";   HMDB:HMDB0014457;   KEGG:C07422;   KEGG:D00499;   LINCS:LSM-1566
 xref_mesh: MESH:D010424
 xref: PMID:15324906 "ChEMBL";   PMID:15801854 "ChEMBL";   PMID:15857133 "ChEMBL";   PMID:16720246 "Europe PMC";   PMID:1977910 "ChEMBL";   PMID:19879734 "Europe PMC";   PMID:2215478 "Europe PMC";   PMID:23246494 "Europe PMC";   PMID:23345614 "Europe PMC";   PMID:23526799 "Europe PMC";   PMID:23663566 "Europe PMC";   PMID:2579237 "ChEMBL";   PMID:3599019 "ChEMBL";   PMID:3654008 "Europe PMC";   PMID:6864729 "ChEMBL";   PMID:7154009 "ChEMBL";   PMID:9016329 "ChEMBL";   PMID:9412440 "Europe PMC";   PMID:9599235 "ChEMBL";   Reaxys:87067 "Reaxys";   VSDB:3000;   Wikipedia:Pentobarbital


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pentobarbital term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A JBrowse link 5 8,567,091 8,748,575 RGD:6480464
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6480464
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 10 90,989,311 91,082,743 RGD:6480464
G App amyloid beta (A4) precursor protein JBrowse link 16 84,952,666 85,175,255 RGD:6480464
G Bcl10 B cell leukemia/lymphoma 10 JBrowse link 3 145,924,262 145,934,366 RGD:6480464
G Bcl2 B cell leukemia/lymphoma 2 JBrowse link 1 106,538,176 106,714,290 RGD:6480464
G Bdnf brain derived neurotrophic factor JBrowse link 2 109,674,700 109,727,043 RGD:6480464
G Blk B lymphoid kinase JBrowse link 14 63,372,837 63,417,187 RGD:6480464
G Bnip3 BCL2/adenovirus E1B interacting protein 3 JBrowse link 7 138,890,836 138,909,506 RGD:6480464
G Cacna1i calcium channel, voltage-dependent, alpha 1I subunit JBrowse link 15 80,287,238 80,398,292 RGD:6480464
G Casp14 caspase 14 JBrowse link 10 78,711,995 78,718,347 RGD:6480464
G Casp7 caspase 7 JBrowse link 19 56,396,833 56,442,348 RGD:6480464
G Casp8 caspase 8 JBrowse link 1 58,795,233 58,847,503 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 7 144,929,931 144,939,937 RGD:6480464
G Ccnd3 cyclin D3 JBrowse link 17 47,505,051 47,599,689 RGD:6480464
G Cd27 CD27 antigen JBrowse link 6 125,232,620 125,237,136 RGD:6480464
G Cd40lg CD40 ligand JBrowse link X 57,212,143 57,224,042 RGD:6480464
G Cdk2 cyclin-dependent kinase 2 JBrowse link 10 128,697,938 128,705,051 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) JBrowse link 17 29,090,979 29,100,722 RGD:6480464
G Chek2 checkpoint kinase 2 JBrowse link 5 110,839,800 110,874,140 RGD:6480464
G Cnr1 cannabinoid receptor 1 (brain) JBrowse link 4 33,923,171 33,948,831 RGD:6480464
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain JBrowse link 10 95,174,739 95,324,138 RGD:6480464
G Crh corticotropin releasing hormone JBrowse link 3 19,693,401 19,695,396 RGD:6480464
G Crhr1 corticotropin releasing hormone receptor 1 JBrowse link 11 104,130,463 104,175,523 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 9 57,676,937 57,683,655 RGD:6480464
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 JBrowse link 7 25,897,658 25,926,624 RGD:6480464
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 JBrowse link 7 26,061,388 26,096,197 RGD:6480464
G Dffa DNA fragmentation factor, alpha subunit JBrowse link 4 149,104,142 149,120,653 RGD:6480464
G Drd2 dopamine receptor D2 JBrowse link 9 49,340,360 49,408,177 RGD:6480464
G Fasl Fas ligand (TNF superfamily, member 6) JBrowse link 1 161,780,691 161,788,495 RGD:6480464
G Folh1 folate hydrolase 1 JBrowse link 7 86,716,525 86,776,053 RGD:6480464
G Fos FBJ osteosarcoma oncogene JBrowse link 12 85,473,890 85,477,274 RGD:6480464
G Fshb follicle stimulating hormone beta JBrowse link 2 107,055,986 107,059,651 RGD:6480464
G Fst follistatin JBrowse link 13 114,452,262 114,458,989 RGD:6480464
G Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 JBrowse link 11 42,130,939 42,183,066 RGD:6480464
G Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 JBrowse link 5 70,958,392 71,095,849 RGD:6480464
G Gabra4 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 JBrowse link 5 71,569,734 71,658,308 RGD:6480464
G Gabra6 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 JBrowse link 11 42,306,437 42,321,072 RGD:6480464
G Gabrb1 gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 JBrowse link 5 71,657,921 72,149,572 RGD:6480464
G Gabrb2 gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 JBrowse link 11 42,419,515 42,632,591 RGD:6480464
G Gabrb3 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 JBrowse link 7 57,590,518 57,828,802 RGD:6480464
G Gabrd gamma-aminobutyric acid (GABA) A receptor, subunit delta JBrowse link 4 155,384,979 155,398,098 RGD:6480464
G Gabre gamma-aminobutyric acid (GABA) A receptor, subunit epsilon JBrowse link X 72,256,926 72,274,828 RGD:6480464
G Gabrg2 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 JBrowse link 11 41,910,190 42,000,857 RGD:6480464
G Gal galanin and GMAP prepropeptide JBrowse link 19 3,409,915 3,414,544 RGD:6480464
G Gap43 growth associated protein 43 JBrowse link 16 42,248,552 42,340,651 RGD:6480464
G Gast gastrin JBrowse link 11 100,334,407 100,336,997 RGD:6480464
G Ghrl ghrelin JBrowse link 6 113,716,119 113,719,911 RGD:6480464
G Gjb1 gap junction protein, beta 1 JBrowse link X 101,376,376 101,385,629 RGD:6480464
G Gnai1 guanine nucleotide binding protein (G protein), alpha inhibiting 1 JBrowse link 5 18,265,135 18,360,413 RGD:6480464
G Gnao1 guanine nucleotide binding protein, alpha O JBrowse link 8 93,810,153 93,969,388 RGD:6480464
G Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus JBrowse link 2 174,284,320 174,346,744 RGD:6480464
G Gnrhr gonadotropin releasing hormone receptor JBrowse link 5 86,180,754 86,197,901 RGD:6480464
G Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) JBrowse link 3 80,681,450 80,804,227 RGD:6480464
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) JBrowse link 2 25,291,177 25,319,253 RGD:6480464
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) JBrowse link 16 9,567,901 9,996,083 RGD:6480464
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) JBrowse link 6 135,713,221 136,173,615 RGD:6480464
G Grin2c glutamate receptor, ionotropic, NMDA2C (epsilon 3) JBrowse link 11 115,249,169 115,267,297 RGD:6480464
G Hcrtr1 hypocretin (orexin) receptor 1 JBrowse link 4 130,130,217 130,139,594 RGD:6480464
G Hcrtr2 hypocretin (orexin) receptor 2 JBrowse link 9 76,225,880 76,323,623 RGD:6480464
G Hspb1 heat shock protein 1 JBrowse link 5 135,887,919 135,889,563 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 9 21,015,940 21,028,814 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Itgae integrin alpha E, epithelial-associated JBrowse link 11 73,090,505 73,147,449 RGD:6480464
G Jun jun proto-oncogene JBrowse link 4 95,049,036 95,052,222 RGD:6480464
G Junb jun B proto-oncogene JBrowse link 8 84,976,909 84,978,748 RGD:6480464
G Jund jun D proto-oncogene JBrowse link 8 70,697,739 70,700,616 RGD:6480464
G Kcne1 potassium voltage-gated channel, Isk-related subfamily, member 1 JBrowse link 16 92,346,001 92,359,468 RGD:6480464
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 JBrowse link 5 24,319,589 24,351,684 RGD:6480464
G Kras Kirsten rat sarcoma viral oncogene homolog JBrowse link 6 145,216,699 145,250,420 RGD:6480464
G Lhb luteinizing hormone beta JBrowse link 7 45,417,608 45,421,855 RGD:6480464
G Ltbr lymphotoxin B receptor JBrowse link 6 125,306,571 125,313,885 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Mcl1 myeloid cell leukemia sequence 1 JBrowse link 3 95,656,944 95,663,179 RGD:6480464
G Med1 mediator complex subunit 1 JBrowse link 11 98,152,154 98,193,313 RGD:6480464
G Mpo myeloperoxidase JBrowse link 11 87,793,784 87,804,412 RGD:6480464
G Myd88 myeloid differentiation primary response gene 88 JBrowse link 9 119,335,934 119,340,018 RGD:6480464
G Nppa natriuretic peptide type A JBrowse link 4 148,000,722 148,002,074 RGD:6480464
G Npy neuropeptide Y JBrowse link 6 49,822,710 49,829,507 RGD:6480464
G Npy1r neuropeptide Y receptor Y1 JBrowse link 8 66,697,149 66,706,800 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 16 38,248,349 38,294,849 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 1 171,213,934 171,218,845 RGD:6480464
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 JBrowse link 15 101,253,902 101,274,795 RGD:6480464
G Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 JBrowse link 7 78,179,986 78,581,034 RGD:6480464
G Pdyn prodynorphin JBrowse link 2 129,686,549 129,699,938 RGD:6480464
G Penk preproenkephalin JBrowse link 4 4,133,536 4,138,815 RGD:6480464
G Pgr progesterone receptor JBrowse link 9 8,898,900 8,968,611 RGD:6480464
G Pomc pro-opiomelanocortin-alpha JBrowse link 12 3,954,945 3,960,643 RGD:6480464
G Por P450 (cytochrome) oxidoreductase JBrowse link 5 135,670,040 135,735,326 RGD:6480464
G Prl prolactin JBrowse link 13 27,057,570 27,065,204 RGD:6480464
G Rac1 Rac family small GTPase 1 JBrowse link 5 143,505,481 143,528,031 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 14 73,192,858 73,325,951 RGD:6480464
G Ren1 renin 1 structural JBrowse link 1 133,350,674 133,360,320 RGD:6480464
G Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 JBrowse link 2 165,405,295 165,473,197 RGD:6480464
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 JBrowse link 4 119,108,745 119,137,330 RGD:6480464
G Sumo1 small ubiquitin-like modifier 1 JBrowse link 1 59,639,434 59,670,834 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b JBrowse link 14 69,767,472 69,784,411 RGD:6480464
G Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator JBrowse link 1 105,780,673 105,849,444 RGD:6480464
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) JBrowse link 15 54,250,619 54,278,484 RGD:6480464
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a JBrowse link 6 125,349,723 125,362,483 RGD:6480464
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 JBrowse link 14 78,277,446 78,308,043 RGD:6480464
G Tnfsf12 tumor necrosis factor (ligand) superfamily, member 12 JBrowse link 11 69,686,240 69,696,098 RGD:6480464
G Tnfsf13 tumor necrosis factor (ligand) superfamily, member 13 JBrowse link 11 69,682,577 69,685,554 RGD:6480464
G Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 JBrowse link 17 57,189,474 57,194,181 RGD:6480464
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 JBrowse link 1 161,395,438 161,418,206 RGD:6480464
G Traf2 TNF receptor-associated factor 2 JBrowse link 2 25,517,982 25,546,940 RGD:6480464
G Traf3 TNF receptor-associated factor 3 JBrowse link 12 111,166,321 111,267,155 RGD:6480464
G Upp1 uridine phosphorylase 1 JBrowse link 11 9,118,008 9,136,170 RGD:6480464
G Xiap X-linked inhibitor of apoptosis JBrowse link X 42,059,613 42,109,664 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20971
    role 20952
      biological role 20950
        biophysical role 12450
          membrane transport modulator 12193
            GABA modulator 4787
              barbiturates 4520
                pentobarbital 111
Path 2
Term Annotations click to browse term
  CHEBI ontology 20971
    subatomic particle 20965
      composite particle 20965
        hadron 20965
          baryon 20965
            nucleon 20965
              atomic nucleus 20965
                atom 20965
                  main group element atom 20803
                    p-block element atom 20803
                      carbon group element atom 20543
                        carbon atom 20519
                          organic molecular entity 20519
                            organic molecule 20371
                              organic cyclic compound 20047
                                organic heterocyclic compound 18970
                                  organic heteromonocyclic compound 16512
                                    diazines 12358
                                      pyrimidines 12175
                                        pyrimidone 8766
                                          barbiturates 4520
                                            pentobarbital 111
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.