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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ziram
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Accession:CHEBI:79736 term browser browse the term
Definition:A dithiocarbamate salt that is the zinc salt of dimethyldithiocarbamic acid. It is a broad-spectrum fungicide and bird and animal repellent that is also used to accelerate the vulcanisation of rubber.
Synonyms:exact_synonym: zinc bis(dimethylcarbamodithioate)
 related_synonym: (T-4)-bis(dimethylcarbamodithioato-kappaS,kappaS')zinc;   Formula=C6H12N2S4Zn;   InChI=1S/2C3H7NS2.Zn/c2*1-4(2)3(5)6;/h2*1-2H3,(H,5,6);/q;;+2/p-2;   InChIKey=DUBNHZYBDBBJHD-UHFFFAOYSA-L;   SMILES=CN(C)C(=S)S[Zn]SC(=S)N(C)C;   bis(dimethylcarbamodithioato-S,S')zinc;   bis(dimethyldithiocarbamato)zinc;   bis-dimethyldithiocarbamate de zinc;   dimethyldithiocarbamate zinc salt;   zinc bis(dimethyldithiocarbamate);   zinc bis(dimethyldithiocarbamoyl)disulphide;   zinc bis(dimethylthiocarbamoyl)disulfide
 xref: CAS:137-30-4;   KEGG:C15229
 xref_mesh: MESH:D015039
 xref: PMID:16007644;   PMID:1842586;   PMID:18818210;   PMID:20842346;   PMID:22159898;   PMID:23298479;   PMID:24750788;   PMID:8478981;   Patent:US2492314;   Pesticides:ziram;   Reaxys:3707008;   Wikipedia:Ziram


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ziram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of ABCC2 mRNA CTD PMID:32745781 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of ABCC3 mRNA CTD PMID:32745781 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of ACOX1 mRNA CTD PMID:32736067 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136 		JBrowse link
G Akr1c14 aldo-keto reductase family 1, member C14 affects binding
decreases activity 		EXP Ziram binds to AKR1C14 protein
Ziram results in decreased activity of AKR1C14 protein 		CTD PMID:28707553 NCBI chr17:71,066,197...71,083,184
Ensembl chr17:71,066,200...71,083,157 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation EXP Ziram results in decreased phosphorylation of AKT1 protein CTD PMID:30422632 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Amh anti-Mullerian hormone decreases expression
increases expression 		EXP Ziram results in decreased expression of AMH mRNA; Ziram results in decreased expression of AMH protein
Ziram results in increased expression of AMH mRNA 		CTD PMID:29627606 PMID:30422632 NCBI chr 7:9,557,451...9,559,867
Ensembl chr 7:9,557,451...9,559,867 		JBrowse link
G Apln apelin increases expression ISO Ziram results in increased expression of APLN mRNA CTD PMID:32870474 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:132,081,759...132,091,246 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Ziram results in increased expression of BAX protein CTD PMID:28973382 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Ziram results in decreased expression of BCL2 protein CTD PMID:28973382 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO Acetylcysteine inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]; Dithiothreitol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]; Edetic Acid inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]; Mercaptoethanol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]; Ziram results in decreased expression of and results in increased degradation of CASP1 protein CTD PMID:25929180 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Casp3 caspase 3 increases activity ISO Ziram results in increased activity of CASP3 protein CTD PMID:20842346 PMID:22159898 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 increases activity ISO Ziram results in increased activity of CASP8 protein CTD PMID:22159898 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases activity ISO Ziram results in increased activity of CASP9 protein CTD PMID:22159898 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase increases expression ISO Ziram results in increased expression of CAT mRNA CTD PMID:32712770 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases secretion 		ISO Ziram inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
Ziram results in decreased secretion of CCL2 protein 		CTD PMID:32712770 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccnd3 cyclin D3 decreases expression EXP Ziram results in decreased expression of CCND3 mRNA CTD PMID:28973382 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression
decreases expression 		ISO Ziram results in increased expression of CCR2 mRNA
Ziram results in decreased expression of CCR2 protein 		CTD PMID:32712770 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059 		JBrowse link
G Cd163 CD163 molecule decreases expression ISO Ziram results in decreased expression of CD163 mRNA; Ziram results in decreased expression of CD163 protein CTD PMID:32712770 NCBI chr 4:158,770,751...158,804,146
Ensembl chr 4:158,770,749...158,804,146 		JBrowse link
G Cd209d CD209d molecule increases expression ISO Ziram results in increased expression of CD209 mRNA; Ziram results in increased expression of CD209 protein CTD PMID:32712770 NCBI chr12:6,689,002...6,695,452
Ensembl chr12:6,689,002...6,698,976 		JBrowse link
G Cd36 CD36 molecule multiple interactions
decreases expression 		ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CD36 mRNA
Ziram results in decreased expression of CD36 mRNA; Ziram results in decreased expression of CD36 protein 		CTD PMID:32712770 PMID:32736067 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Clec7a C-type lectin domain containing 7A decreases expression ISO Ziram results in decreased expression of CLEC7A protein CTD PMID:32712770 NCBI chr 4:164,588,737...164,599,953
Ensembl chr 4:164,588,754...164,599,919 		JBrowse link
G Cnn2 calponin 2 increases expression ISO Ziram results in increased expression of CNN2 mRNA CTD PMID:32870474 NCBI chr 7:10,363,141...10,370,312
Ensembl chr 7:10,363,102...10,370,312 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CPT1A mRNA CTD PMID:32736067 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Ziram affects the localization of CYCS protein CTD PMID:20842346 PMID:22159898 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases activity
decreases expression
affects expression 		EXP Ziram results in decreased activity of CYP11A1 protein
Ziram results in decreased expression of CYP11A1 mRNA; Ziram results in decreased expression of CYP11A1 protein
Ziram affects the expression of CYP11A1 mRNA; Ziram affects the expression of CYP11A1 protein 		CTD PMID:28973382 PMID:29627606 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
decreases activity
affects expression 		EXP Ziram results in decreased expression of CYP17A1 mRNA; Ziram results in decreased expression of CYP17A1 protein
Ziram results in decreased activity of CYP17A1 protein
Ziram affects the expression of CYP17A1 mRNA; Ziram affects the expression of CYP17A1 protein 		CTD PMID:28973382 PMID:29627606 PMID:30422632 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2B10 mRNA; [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CYP2B10 mRNA CTD PMID:32736067 PMID:32745781 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CYP2C55 mRNA CTD PMID:32736067 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:246,286,341...246,348,607 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2C29 mRNA CTD PMID:32745781 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Ziram results in increased expression of DDIT3 mRNA CTD PMID:32870474 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Dhh desert hedgehog signaling molecule decreases expression EXP Ziram results in decreased expression of DHH mRNA; Ziram results in decreased expression of DHH protein CTD PMID:29627606 NCBI chr 7:130,050,910...130,056,406
Ensembl chr 7:131,929,857...131,935,352 		JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of DIO1 mRNA CTD PMID:32745781 NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771 		JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of ECI1 mRNA CTD PMID:32736067 NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,961,218...13,974,773 		JBrowse link
G Elfn2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 increases expression ISO Ziram results in increased expression of ELFN2 mRNA CTD PMID:32870474 NCBI chr 7:112,101,998...112,153,280
Ensembl chr 7:112,074,331...112,153,451 		JBrowse link
G Fcgr3a Fc gamma receptor 3A decreases expression ISO Ziram results in decreased expression of FCGR3A protein CTD PMID:18670896 NCBI chr13:85,782,636...85,792,656
Ensembl chr13:85,782,490...85,792,651 		JBrowse link
G Fibin fin bud initiation factor homolog increases expression ISO Ziram results in increased expression of FIBIN mRNA CTD PMID:32870474 NCBI chr 3:117,396,973...117,399,244
Ensembl chr 3:117,391,724...117,399,479 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Ziram results in decreased expression of FSHB mRNA; Ziram results in decreased expression of FSHB protein CTD PMID:28973382 PMID:30422632 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072 		JBrowse link
G Fshr follicle stimulating hormone receptor decreases expression EXP Ziram results in decreased expression of FSHR mRNA; Ziram results in decreased expression of FSHR protein CTD PMID:29627606 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:10,952,329...11,160,288 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of GFAP protein CTD PMID:32736067 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685 		JBrowse link
G Gzma granzyme A decreases expression ISO Ziram results in decreased expression of GZMA protein CTD PMID:22038140 NCBI chr 2:46,473,763...46,485,696
Ensembl chr 2:46,473,763...46,485,696 		JBrowse link
G Gzmb granzyme B decreases expression ISO Ziram results in decreased expression of GZMB protein CTD PMID:21859362 PMID:22038140 NCBI chr15:34,459,007...34,462,469
Ensembl chr15:34,459,007...34,462,469 		JBrowse link
G Gzmk granzyme K decreases expression ISO Ziram results in decreased expression of GZMK protein CTD PMID:22038140 NCBI chr 2:46,573,997...46,582,015
Ensembl chr 2:46,573,997...46,582,015 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of HMGCS2 mRNA CTD PMID:32745781 NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression 		ISO Trientine inhibits the reaction [Ziram results in increased expression of HMOX1 protein]
Ziram results in increased expression of HMOX1 mRNA; Ziram results in increased expression of HMOX1 protein 		CTD PMID:25714994 PMID:32712770 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions
decreases activity
decreases expression 		EXP Ziram inhibits the reaction [[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone]; Ziram inhibits the reaction [HSD11B1 protein results in increased oxidation of NADP]; Ziram inhibits the reaction [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone]
Ziram results in decreased activity of HSD11B1 protein
Ziram results in decreased expression of HSD11B1 mRNA; Ziram results in decreased expression of HSD11B1 protein 		CTD PMID:26859423 PMID:28973382 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
decreases activity 		ISO
EXP 		Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein]; Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone]; Ziram inhibits the reaction [HSD11B2 protein results in increased oxidation of Hydrocortisone]; Ziram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD]
Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein]; Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone]; Ziram inhibits the reaction [HSD11B2 protein results in increased oxidation of Corticosterone]; Ziram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD] 		CTD PMID:26859423 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases activity
decreases expression 		EXP Ziram results in decreased activity of HSD17B3 protein
Ziram results in decreased expression of HSD17B3 mRNA; Ziram results in decreased expression of HSD17B3 protein 		CTD PMID:28973382 PMID:29627606 PMID:30422632 NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases activity
decreases expression 		EXP Ziram results in decreased activity of HSD3B1 protein
Ziram results in decreased expression of HSD3B1 mRNA; Ziram results in decreased expression of HSD3B1 protein 		CTD PMID:28973382 NCBI chr 2:188,858,574...188,864,694 JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Ziram inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:18177342 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487 		JBrowse link
G Ifng interferon gamma increases expression ISO Ziram results in increased expression of IFNG protein CTD PMID:12062936 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Ziram inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Ziram inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] 		CTD PMID:25929180 PMID:32712770 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 increases expression ISO Ziram results in increased expression of IL4 protein CTD PMID:12062936 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Ziram inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:32712770 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of INS1 protein CTD PMID:32745781 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Insl3 insulin-like 3 decreases expression EXP Ziram results in decreased expression of INSL3 mRNA; Ziram results in decreased expression of INSL3 protein CTD PMID:29627606 NCBI chr16:18,432,668...18,434,539 JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Ziram results in increased expression of ITGAM mRNA; Ziram results in increased expression of ITGAM protein CTD PMID:32712770 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
G Lep leptin multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lepr leptin receptor multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of LEPR mRNA CTD PMID:29321614 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression
affects expression 		EXP Ziram results in decreased expression of LHCGR mRNA; Ziram results in decreased expression of LHCGR protein
Ziram affects the expression of LHCGR mRNA; Ziram affects the expression of LHCGR protein 		CTD PMID:28973382 PMID:29627606 PMID:30422632 NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:11,415,415...11,478,061 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity ISO Ziram results in increased activity of MAPK1 protein CTD PMID:21859362 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity ISO Ziram results in increased activity of MAPK3 protein CTD PMID:21859362 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mrc1 mannose receptor, C type 1 decreases expression ISO Ziram results in decreased expression of MRC1 protein CTD PMID:32712770 NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410 		JBrowse link
G Mt1-ps3 metallothionein 1, pseudogene 3 increases expression ISO Ziram results in increased expression of MT1E mRNA CTD PMID:32870474 NCBI chr17:79,695,812...79,696,200
Ensembl chr17:79,695,809...79,696,200 		JBrowse link
G Mt2 metallothionein 2 increases expression ISO Ziram results in increased expression of MT2A mRNA CTD PMID:32870474 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709 		JBrowse link
G Mt4 metallothionein 4 decreases expression ISO Ziram results in decreased expression of MT4 mRNA CTD PMID:32870474 NCBI chr19:10,869,735...10,871,831
Ensembl chr19:10,869,735...10,871,831 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects expression ISO Ziram affects the expression of NFE2L2 mRNA CTD PMID:32712770 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Ziram inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:17015962 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 decreases expression ISO Ziram results in decreased expression of NLRP3 protein CTD PMID:25929180 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nmb neuromedin B multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of NMB mRNA CTD PMID:29321614 NCBI chr 1:144,278,678...144,290,523
Ensembl chr 1:144,278,453...144,281,422 		JBrowse link
G Nmbr neuromedin B receptor multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NMBR mRNA CTD PMID:29321614 NCBI chr 1:10,942,476...10,966,174
Ensembl chr 1:10,954,916...10,965,555 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NPY1R mRNA CTD PMID:29321614 NCBI chr16:27,804,416...27,814,070
Ensembl chr16:27,804,416...27,813,387 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the susceptibility to [2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with Thiophanate co-treated with thiacloprid co-treated with Ziram] CTD PMID:29950287 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression
affects expression 		EXP Ziram results in decreased expression of NR5A1 mRNA; Ziram results in decreased expression of NR5A1 protein
Ziram affects the expression of NR5A1 mRNA; Ziram affects the expression of NR5A1 protein 		CTD PMID:28973382 PMID:29627606 NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046 		JBrowse link
G Park7 Parkinsonism associated deglycase decreases activity ISO Ziram results in decreased activity of PARK7 protein CTD PMID:36842454 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of PDGFRB protein CTD PMID:32736067 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 affects expression ISO Ziram affects the expression of PDK4 mRNA CTD PMID:32870474 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:34,556,330...34,568,381 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO Ziram affects the expression of PPARG mRNA CTD PMID:32712770 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression EXP Ziram results in decreased expression of PPARGC1A protein CTD PMID:30422632 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Prf1 perforin 1 decreases expression ISO Ziram results in decreased expression of PRF1 protein CTD PMID:21859362 PMID:22038140 NCBI chr20:29,789,040...29,794,550
Ensembl chr20:29,788,972...29,795,124 		JBrowse link
G Prss56 serine protease 56 increases expression ISO Ziram results in increased expression of PRSS56 mRNA CTD PMID:32870474 NCBI chr 9:87,842,806...87,859,978
Ensembl chr 9:95,302,772...95,307,877 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
affects expression 		EXP Ziram results in decreased expression of SCARB1 mRNA; Ziram results in decreased expression of SCARB1 protein
Ziram affects the expression of SCARB1 mRNA; Ziram affects the expression of SCARB1 protein 		CTD PMID:28973382 PMID:29627606 PMID:30422632 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SERPINE1 mRNA CTD PMID:32745781 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Sirt1 sirtuin 1 decreases expression EXP Ziram results in decreased expression of SIRT1 protein CTD PMID:30422632 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SLC16A2 mRNA CTD PMID:32745781 NCBI chr  X:72,791,096...72,914,299
Ensembl chr  X:72,781,876...72,914,498 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 increases expression ISO Ziram results in increased expression of SLC30A1 mRNA CTD PMID:32870474 NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892 		JBrowse link
G Slc30a2 solute carrier family 30 member 2 increases expression ISO Ziram results in increased expression of SLC30A2 mRNA CTD PMID:32870474 NCBI chr 5:146,559,733...146,571,957
Ensembl chr 5:151,843,389...151,855,670 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Ziram results in increased expression of SLC7A11 mRNA CTD PMID:32870474 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Slc8a3 solute carrier family 8 member A3 increases response to substance
decreases response to substance 		EXP
ISO 		SLC8A3 results in increased susceptibility to Ziram
SLC8A3 gene mutant form results in decreased susceptibility to Ziram 		CTD PMID:25284465 NCBI chr 6:106,605,611...106,739,208
Ensembl chr 6:106,605,621...106,721,412 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO Ziram inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Snca synuclein alpha increases expression EXP Ziram results in increased expression of SNCA protein CTD PMID:18818210 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Ziram results in increased expression of SOD2 mRNA CTD PMID:32712770 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression EXP Ziram results in decreased expression of SOX9 mRNA; Ziram results in decreased expression of SOX9 protein CTD PMID:29627606 NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression
decreases activity 		EXP Ziram results in decreased expression of SRD5A1 mRNA
Ziram results in decreased activity of SRD5A1 protein 		CTD PMID:28707553 PMID:30422632 NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:35,514,846...35,548,903 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
affects expression 		EXP Ziram results in decreased expression of STAR mRNA; Ziram results in decreased expression of STAR protein
Ziram affects the expression of STAR mRNA; Ziram affects the expression of STAR protein 		CTD PMID:28973382 PMID:29627606 PMID:30422632 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SULT1B1 mRNA CTD PMID:32745781 NCBI chr14:20,771,917...20,784,665
Ensembl chr14:20,771,868...20,785,549 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity
multiple interactions 		ISO Ziram results in decreased activity of TGFB1 protein
Ziram inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] 		CTD PMID:31652400 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO [2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of THRSP mRNA; [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in decreased expression of THRSP mRNA; Dietary Fats inhibits the reaction [[2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of THRSP mRNA] CTD PMID:32745781 NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:161,133,453...161,139,827 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ziram inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:16112155 PMID:32712770 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tpo thyroid peroxidase decreases activity ISO Ziram results in decreased activity of TPO protein CTD PMID:9248629 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:52,426,010...52,495,793 		JBrowse link
G Tspo translocator protein decreases expression EXP Ziram results in decreased expression of TSPO mRNA CTD PMID:28973382 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460 		JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 decreases activity
multiple interactions 		ISO Ziram results in decreased activity of UBA1 protein
Trientine inhibits the reaction [Ziram results in decreased activity of and results in decreased ubiquitination of UBA1 protein]; Ziram results in decreased activity of and results in decreased ubiquitination of UBA1 protein 		CTD PMID:18818210 PMID:25714994 NCBI chr  X:1,508,700...1,530,677
Ensembl chr  X:4,062,182...4,084,246 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          apoptosis inducer 13731
            ziram 101
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organosulfur compound 17763
                                  thiocarbonyl compound 10404
                                    dithiocarbamic acids 4613
                                      dimethyldithiocarbamic acid 4430
                                        ziram 101
paths to the root