|
G
|
Abcc2
|
ATP binding cassette subfamily C member 2
|
multiple interactions
|
ISO
|
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of ABCC2 mRNA
|
CTD |
PMID:32745781 |
|
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
|
|
G
|
Abcc3
|
ATP binding cassette subfamily C member 3
|
multiple interactions
|
ISO
|
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of ABCC3 mRNA
|
CTD |
PMID:32745781 |
|
NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494
|
|
G
|
Acox1
|
acyl-CoA oxidase 1
|
multiple interactions
|
ISO
|
[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of ACOX1 mRNA
|
CTD |
PMID:32736067 |
|
NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136
|
|
G
|
Akr1c14
|
aldo-keto reductase family 1, member C14
|
affects binding decreases activity
|
EXP
|
Ziram binds to AKR1C14 protein Ziram results in decreased activity of AKR1C14 protein
|
CTD |
PMID:28707553 |
|
NCBI chr17:71,066,197...71,083,184
Ensembl chr17:71,066,200...71,083,157
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
decreases phosphorylation
|
EXP
|
Ziram results in decreased phosphorylation of AKT1 protein
|
CTD |
PMID:30422632 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
|
|
G
|
Amh
|
anti-Mullerian hormone
|
decreases expression increases expression
|
EXP
|
Ziram results in decreased expression of AMH mRNA; Ziram results in decreased expression of AMH protein Ziram results in increased expression of AMH mRNA
|
CTD |
PMID:29627606 PMID:30422632 |
|
NCBI chr 7:9,557,451...9,559,867
Ensembl chr 7:9,557,451...9,559,867
|
|
G
|
Apln
|
apelin
|
increases expression
|
ISO
|
Ziram results in increased expression of APLN mRNA
|
CTD |
PMID:32870474 |
|
NCBI chr X:127,180,801...127,213,567
Ensembl chr X:132,081,759...132,091,246
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
increases expression
|
EXP
|
Ziram results in increased expression of BAX protein
|
CTD |
PMID:28973382 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
decreases expression
|
EXP
|
Ziram results in decreased expression of BCL2 protein
|
CTD |
PMID:28973382 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Casp1
|
caspase 1
|
multiple interactions
|
ISO
|
Acetylcysteine inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]; Dithiothreitol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]; Edetic Acid inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]; Mercaptoethanol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]; Ziram results in decreased expression of and results in increased degradation of CASP1 protein
|
CTD |
PMID:25929180 |
|
NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
|
|
G
|
Casp3
|
caspase 3
|
increases activity
|
ISO
|
Ziram results in increased activity of CASP3 protein
|
CTD |
PMID:20842346 PMID:22159898 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp8
|
caspase 8
|
increases activity
|
ISO
|
Ziram results in increased activity of CASP8 protein
|
CTD |
PMID:22159898 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
|
|
G
|
Casp9
|
caspase 9
|
increases activity
|
ISO
|
Ziram results in increased activity of CASP9 protein
|
CTD |
PMID:22159898 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
G
|
Cat
|
catalase
|
increases expression
|
ISO
|
Ziram results in increased expression of CAT mRNA
|
CTD |
PMID:32712770 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Ccl2
|
C-C motif chemokine ligand 2
|
multiple interactions decreases secretion
|
ISO
|
Ziram inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] Ziram results in decreased secretion of CCL2 protein
|
CTD |
PMID:32712770 |
|
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
|
|
G
|
Ccnd3
|
cyclin D3
|
decreases expression
|
EXP
|
Ziram results in decreased expression of CCND3 mRNA
|
CTD |
PMID:28973382 |
|
NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033
|
|
G
|
Ccr2
|
C-C motif chemokine receptor 2
|
increases expression decreases expression
|
ISO
|
Ziram results in increased expression of CCR2 mRNA Ziram results in decreased expression of CCR2 protein
|
CTD |
PMID:32712770 |
|
NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059
|
|
G
|
Cd163
|
CD163 molecule
|
decreases expression
|
ISO
|
Ziram results in decreased expression of CD163 mRNA; Ziram results in decreased expression of CD163 protein
|
CTD |
PMID:32712770 |
|
NCBI chr 4:158,770,751...158,804,146
Ensembl chr 4:158,770,749...158,804,146
|
|
G
|
Cd209d
|
CD209d molecule
|
increases expression
|
ISO
|
Ziram results in increased expression of CD209 mRNA; Ziram results in increased expression of CD209 protein
|
CTD |
PMID:32712770 |
|
NCBI chr12:6,689,002...6,695,452
Ensembl chr12:6,689,002...6,698,976
|
|
G
|
Cd36
|
CD36 molecule
|
multiple interactions decreases expression
|
ISO
|
[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CD36 mRNA Ziram results in decreased expression of CD36 mRNA; Ziram results in decreased expression of CD36 protein
|
CTD |
PMID:32712770 PMID:32736067 |
|
NCBI chr 4:18,209,088...18,302,142
|
|
G
|
Clec7a
|
C-type lectin domain containing 7A
|
decreases expression
|
ISO
|
Ziram results in decreased expression of CLEC7A protein
|
CTD |
PMID:32712770 |
|
NCBI chr 4:164,588,737...164,599,953
Ensembl chr 4:164,588,754...164,599,919
|
|
G
|
Cnn2
|
calponin 2
|
increases expression
|
ISO
|
Ziram results in increased expression of CNN2 mRNA
|
CTD |
PMID:32870474 |
|
NCBI chr 7:10,363,141...10,370,312
Ensembl chr 7:10,363,102...10,370,312
|
|
G
|
Cpt1a
|
carnitine palmitoyltransferase 1A
|
multiple interactions
|
ISO
|
[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CPT1A mRNA
|
CTD |
PMID:32736067 |
|
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326
|
|
G
|
Cycs
|
cytochrome c, somatic
|
affects localization
|
ISO
|
Ziram affects the localization of CYCS protein
|
CTD |
PMID:20842346 PMID:22159898 |
|
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816 Ensembl chr18:80,982,668...80,984,816
|
|
G
|
Cyp11a1
|
cytochrome P450, family 11, subfamily a, polypeptide 1
|
decreases activity decreases expression affects expression
|
EXP
|
Ziram results in decreased activity of CYP11A1 protein Ziram results in decreased expression of CYP11A1 mRNA; Ziram results in decreased expression of CYP11A1 protein Ziram affects the expression of CYP11A1 mRNA; Ziram affects the expression of CYP11A1 protein
|
CTD |
PMID:28973382 PMID:29627606 |
|
NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196
|
|
G
|
Cyp17a1
|
cytochrome P450, family 17, subfamily a, polypeptide 1
|
decreases expression decreases activity affects expression
|
EXP
|
Ziram results in decreased expression of CYP17A1 mRNA; Ziram results in decreased expression of CYP17A1 protein Ziram results in decreased activity of CYP17A1 protein Ziram affects the expression of CYP17A1 mRNA; Ziram affects the expression of CYP17A1 protein
|
CTD |
PMID:28973382 PMID:29627606 PMID:30422632 |
|
NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974
|
|
G
|
Cyp2b3
|
cytochrome P450, family 2, subfamily b, polypeptide 3
|
multiple interactions
|
ISO
|
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2B10 mRNA; [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CYP2B10 mRNA
|
CTD |
PMID:32736067 PMID:32745781 |
|
NCBI chr 1:90,780,468...90,859,852
|
|
G
|
Cyp2c24
|
cytochrome P450, family 2, subfamily c, polypeptide 24
|
multiple interactions
|
ISO
|
[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CYP2C55 mRNA
|
CTD |
PMID:32736067 |
|
NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:246,286,341...246,348,607
|
|
G
|
Cyp2c6
|
cytochrome P450, family 2, subfamily C, polypeptide 6
|
multiple interactions
|
ISO
|
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2C29 mRNA
|
CTD |
PMID:32745781 |
|
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
|
|
G
|
Ddit3
|
DNA-damage inducible transcript 3
|
increases expression
|
ISO
|
Ziram results in increased expression of DDIT3 mRNA
|
CTD |
PMID:32870474 |
|
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
|
|
G
|
Dhh
|
desert hedgehog signaling molecule
|
decreases expression
|
EXP
|
Ziram results in decreased expression of DHH mRNA; Ziram results in decreased expression of DHH protein
|
CTD |
PMID:29627606 |
|
NCBI chr 7:130,050,910...130,056,406
Ensembl chr 7:131,929,857...131,935,352
|
|
G
|
Dio1
|
iodothyronine deiodinase 1
|
multiple interactions
|
ISO
|
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of DIO1 mRNA
|
CTD |
PMID:32745781 |
|
NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771
|
|
G
|
Eci1
|
enoyl-CoA delta isomerase 1
|
multiple interactions
|
ISO
|
[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of ECI1 mRNA
|
CTD |
PMID:32736067 |
|
NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,961,218...13,974,773
|
|
G
|
Elfn2
|
extracellular leucine-rich repeat and fibronectin type III domain containing 2
|
increases expression
|
ISO
|
Ziram results in increased expression of ELFN2 mRNA
|
CTD |
PMID:32870474 |
|
NCBI chr 7:112,101,998...112,153,280
Ensembl chr 7:112,074,331...112,153,451
|
|
G
|
Fcgr3a
|
Fc gamma receptor 3A
|
decreases expression
|
ISO
|
Ziram results in decreased expression of FCGR3A protein
|
CTD |
PMID:18670896 |
|
NCBI chr13:85,782,636...85,792,656
Ensembl chr13:85,782,490...85,792,651
|
|
G
|
Fibin
|
fin bud initiation factor homolog
|
increases expression
|
ISO
|
Ziram results in increased expression of FIBIN mRNA
|
CTD |
PMID:32870474 |
|
NCBI chr 3:117,396,973...117,399,244
Ensembl chr 3:117,391,724...117,399,479
|
|
G
|
Fshb
|
follicle stimulating hormone subunit beta
|
decreases expression
|
EXP
|
Ziram results in decreased expression of FSHB mRNA; Ziram results in decreased expression of FSHB protein
|
CTD |
PMID:28973382 PMID:30422632 |
|
NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072
|
|
G
|
Fshr
|
follicle stimulating hormone receptor
|
decreases expression
|
EXP
|
Ziram results in decreased expression of FSHR mRNA; Ziram results in decreased expression of FSHR protein
|
CTD |
PMID:29627606 |
|
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:10,952,329...11,160,288
|
|
G
|
Gfap
|
glial fibrillary acidic protein
|
multiple interactions
|
ISO
|
[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of GFAP protein
|
CTD |
PMID:32736067 |
|
NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
|
|
G
|
Gzma
|
granzyme A
|
decreases expression
|
ISO
|
Ziram results in decreased expression of GZMA protein
|
CTD |
PMID:22038140 |
|
NCBI chr 2:46,473,763...46,485,696
Ensembl chr 2:46,473,763...46,485,696
|
|
G
|
Gzmb
|
granzyme B
|
decreases expression
|
ISO
|
Ziram results in decreased expression of GZMB protein
|
CTD |
PMID:21859362 PMID:22038140 |
|
NCBI chr15:34,459,007...34,462,469
Ensembl chr15:34,459,007...34,462,469
|
|
G
|
Gzmk
|
granzyme K
|
decreases expression
|
ISO
|
Ziram results in decreased expression of GZMK protein
|
CTD |
PMID:22038140 |
|
NCBI chr 2:46,573,997...46,582,015
Ensembl chr 2:46,573,997...46,582,015
|
|
G
|
Hmgcs2
|
3-hydroxy-3-methylglutaryl-CoA synthase 2
|
multiple interactions
|
ISO
|
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of HMGCS2 mRNA
|
CTD |
PMID:32745781 |
|
NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242
|
|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions increases expression
|
ISO
|
Trientine inhibits the reaction [Ziram results in increased expression of HMOX1 protein] Ziram results in increased expression of HMOX1 mRNA; Ziram results in increased expression of HMOX1 protein
|
CTD |
PMID:25714994 PMID:32712770 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
|
|
G
|
Hsd11b1
|
hydroxysteroid 11-beta dehydrogenase 1
|
multiple interactions decreases activity decreases expression
|
EXP
|
Ziram inhibits the reaction [[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone]; Ziram inhibits the reaction [HSD11B1 protein results in increased oxidation of NADP]; Ziram inhibits the reaction [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] Ziram results in decreased activity of HSD11B1 protein Ziram results in decreased expression of HSD11B1 mRNA; Ziram results in decreased expression of HSD11B1 protein
|
CTD |
PMID:26859423 PMID:28973382 |
|
NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432
|
|
G
|
Hsd11b2
|
hydroxysteroid 11-beta dehydrogenase 2
|
multiple interactions decreases activity
|
ISO EXP
|
Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein]; Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone]; Ziram inhibits the reaction [HSD11B2 protein results in increased oxidation of Hydrocortisone]; Ziram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD] Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein]; Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone]; Ziram inhibits the reaction [HSD11B2 protein results in increased oxidation of Corticosterone]; Ziram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD]
|
CTD |
PMID:26859423 |
|
NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812
|
|
G
|
Hsd17b3
|
hydroxysteroid (17-beta) dehydrogenase 3
|
decreases activity decreases expression
|
EXP
|
Ziram results in decreased activity of HSD17B3 protein Ziram results in decreased expression of HSD17B3 mRNA; Ziram results in decreased expression of HSD17B3 protein
|
CTD |
PMID:28973382 PMID:29627606 PMID:30422632 |
|
NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283
|
|
G
|
Hsd3b1
|
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
|
decreases activity decreases expression
|
EXP
|
Ziram results in decreased activity of HSD3B1 protein Ziram results in decreased expression of HSD3B1 mRNA; Ziram results in decreased expression of HSD3B1 protein
|
CTD |
PMID:28973382 |
|
NCBI chr 2:188,858,574...188,864,694
|
|
G
|
Ifnb1
|
interferon beta 1
|
multiple interactions
|
ISO
|
Ziram inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]
|
CTD |
PMID:18177342 |
|
NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487
|
|
G
|
Ifng
|
interferon gamma
|
increases expression
|
ISO
|
Ziram results in increased expression of IFNG protein
|
CTD |
PMID:12062936 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
ISO
|
Ziram inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] Ziram inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
|
CTD |
PMID:25929180 PMID:32712770 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il4
|
interleukin 4
|
increases expression
|
ISO
|
Ziram results in increased expression of IL4 protein
|
CTD |
PMID:12062936 |
|
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
Ziram inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
|
CTD |
PMID:32712770 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Ins1
|
insulin 1
|
multiple interactions
|
ISO
|
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of INS1 protein
|
CTD |
PMID:32745781 |
|
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
|
|
G
|
Insl3
|
insulin-like 3
|
decreases expression
|
EXP
|
Ziram results in decreased expression of INSL3 mRNA; Ziram results in decreased expression of INSL3 protein
|
CTD |
PMID:29627606 |
|
NCBI chr16:18,432,668...18,434,539
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G
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Itgam
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integrin subunit alpha M
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increases expression
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ISO
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Ziram results in increased expression of ITGAM mRNA; Ziram results in increased expression of ITGAM protein
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CTD |
PMID:32712770 |
|
NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943
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G
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Lep
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leptin
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multiple interactions
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EXP
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[2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein
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CTD |
PMID:29321614 |
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NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
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G
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Lepr
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leptin receptor
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multiple interactions
|
EXP
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[2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of LEPR mRNA
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CTD |
PMID:29321614 |
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NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215
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G
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Lhcgr
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luteinizing hormone/choriogonadotropin receptor
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decreases expression affects expression
|
EXP
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Ziram results in decreased expression of LHCGR mRNA; Ziram results in decreased expression of LHCGR protein Ziram affects the expression of LHCGR mRNA; Ziram affects the expression of LHCGR protein
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CTD |
PMID:28973382 PMID:29627606 PMID:30422632 |
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NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:11,415,415...11,478,061
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G
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Mapk1
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mitogen activated protein kinase 1
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increases activity
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ISO
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Ziram results in increased activity of MAPK1 protein
|
CTD |
PMID:21859362 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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G
|
Mapk3
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mitogen activated protein kinase 3
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increases activity
|
ISO
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Ziram results in increased activity of MAPK3 protein
|
CTD |
PMID:21859362 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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G
|
Mrc1
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mannose receptor, C type 1
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decreases expression
|
ISO
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Ziram results in decreased expression of MRC1 protein
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CTD |
PMID:32712770 |
|
NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410
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G
|
Mt1-ps3
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metallothionein 1, pseudogene 3
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increases expression
|
ISO
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Ziram results in increased expression of MT1E mRNA
|
CTD |
PMID:32870474 |
|
NCBI chr17:79,695,812...79,696,200
Ensembl chr17:79,695,809...79,696,200
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G
|
Mt2
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metallothionein 2
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increases expression
|
ISO
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Ziram results in increased expression of MT2A mRNA
|
CTD |
PMID:32870474 |
|
NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709
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G
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Mt4
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metallothionein 4
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decreases expression
|
ISO
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Ziram results in decreased expression of MT4 mRNA
|
CTD |
PMID:32870474 |
|
NCBI chr19:10,869,735...10,871,831
Ensembl chr19:10,869,735...10,871,831
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G
|
Nfe2l2
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NFE2 like bZIP transcription factor 2
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affects expression
|
ISO
|
Ziram affects the expression of NFE2L2 mRNA
|
CTD |
PMID:32712770 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
|
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G
|
Nfkb1
|
nuclear factor kappa B subunit 1
|
multiple interactions
|
ISO
|
Ziram inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]
|
CTD |
PMID:17015962 |
|
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
|
|
G
|
Nlrp3
|
NLR family, pyrin domain containing 3
|
decreases expression
|
ISO
|
Ziram results in decreased expression of NLRP3 protein
|
CTD |
PMID:25929180 |
|
NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
|
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G
|
Nmb
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neuromedin B
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multiple interactions
|
EXP
|
[2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of NMB mRNA
|
CTD |
PMID:29321614 |
|
NCBI chr 1:144,278,678...144,290,523
Ensembl chr 1:144,278,453...144,281,422
|
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G
|
Nmbr
|
neuromedin B receptor
|
multiple interactions
|
EXP
|
[2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NMBR mRNA
|
CTD |
PMID:29321614 |
|
NCBI chr 1:10,942,476...10,966,174
Ensembl chr 1:10,954,916...10,965,555
|
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G
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Npy1r
|
neuropeptide Y receptor Y1
|
multiple interactions
|
EXP
|
[2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NPY1R mRNA
|
CTD |
PMID:29321614 |
|
NCBI chr16:27,804,416...27,814,070
Ensembl chr16:27,804,416...27,813,387
|
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G
|
Nr1i3
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nuclear receptor subfamily 1, group I, member 3
|
multiple interactions
|
ISO
|
NR1I3 protein affects the susceptibility to [2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with Thiophanate co-treated with thiacloprid co-treated with Ziram]
|
CTD |
PMID:29950287 |
|
NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370
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G
|
Nr5a1
|
nuclear receptor subfamily 5, group A, member 1
|
decreases expression affects expression
|
EXP
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Ziram results in decreased expression of NR5A1 mRNA; Ziram results in decreased expression of NR5A1 protein Ziram affects the expression of NR5A1 mRNA; Ziram affects the expression of NR5A1 protein
|
CTD |
PMID:28973382 PMID:29627606 |
|
NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046
|
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G
|
Park7
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Parkinsonism associated deglycase
|
decreases activity
|
ISO
|
Ziram results in decreased activity of PARK7 protein
|
CTD |
PMID:36842454 |
|
NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825
|
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G
|
Pdgfrb
|
platelet derived growth factor receptor beta
|
multiple interactions
|
ISO
|
[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of PDGFRB protein
|
CTD |
PMID:32736067 |
|
NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233
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G
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Pdk4
|
pyruvate dehydrogenase kinase 4
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affects expression
|
ISO
|
Ziram affects the expression of PDK4 mRNA
|
CTD |
PMID:32870474 |
|
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:34,556,330...34,568,381
|
|
G
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Pparg
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peroxisome proliferator-activated receptor gamma
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affects expression
|
ISO
|
Ziram affects the expression of PPARG mRNA
|
CTD |
PMID:32712770 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
|
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G
|
Ppargc1a
|
PPARG coactivator 1 alpha
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decreases expression
|
EXP
|
Ziram results in decreased expression of PPARGC1A protein
|
CTD |
PMID:30422632 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
|
|
G
|
Prf1
|
perforin 1
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decreases expression
|
ISO
|
Ziram results in decreased expression of PRF1 protein
|
CTD |
PMID:21859362 PMID:22038140 |
|
NCBI chr20:29,789,040...29,794,550
Ensembl chr20:29,788,972...29,795,124
|
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G
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Prss56
|
serine protease 56
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increases expression
|
ISO
|
Ziram results in increased expression of PRSS56 mRNA
|
CTD |
PMID:32870474 |
|
NCBI chr 9:87,842,806...87,859,978
Ensembl chr 9:95,302,772...95,307,877
|
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G
|
Scarb1
|
scavenger receptor class B, member 1
|
decreases expression affects expression
|
EXP
|
Ziram results in decreased expression of SCARB1 mRNA; Ziram results in decreased expression of SCARB1 protein Ziram affects the expression of SCARB1 mRNA; Ziram affects the expression of SCARB1 protein
|
CTD |
PMID:28973382 PMID:29627606 PMID:30422632 |
|
NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980
|
|
G
|
Serpine1
|
serpin family E member 1
|
multiple interactions
|
ISO
|
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SERPINE1 mRNA
|
CTD |
PMID:32745781 |
|
NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357
|
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G
|
Sirt1
|
sirtuin 1
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decreases expression
|
EXP
|
Ziram results in decreased expression of SIRT1 protein
|
CTD |
PMID:30422632 |
|
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
|
|
G
|
Slc16a2
|
solute carrier family 16 member 2
|
multiple interactions
|
ISO
|
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SLC16A2 mRNA
|
CTD |
PMID:32745781 |
|
NCBI chr X:72,791,096...72,914,299
Ensembl chr X:72,781,876...72,914,498
|
|
G
|
Slc30a1
|
solute carrier family 30 member 1
|
increases expression
|
ISO
|
Ziram results in increased expression of SLC30A1 mRNA
|
CTD |
PMID:32870474 |
|
NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892
|
|
G
|
Slc30a2
|
solute carrier family 30 member 2
|
increases expression
|
ISO
|
Ziram results in increased expression of SLC30A2 mRNA
|
CTD |
PMID:32870474 |
|
NCBI chr 5:146,559,733...146,571,957
Ensembl chr 5:151,843,389...151,855,670
|
|
G
|
Slc7a11
|
solute carrier family 7 member 11
|
increases expression
|
ISO
|
Ziram results in increased expression of SLC7A11 mRNA
|
CTD |
PMID:32870474 |
|
NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
|
|
G
|
Slc8a3
|
solute carrier family 8 member A3
|
increases response to substance decreases response to substance
|
EXP ISO
|
SLC8A3 results in increased susceptibility to Ziram SLC8A3 gene mutant form results in decreased susceptibility to Ziram
|
CTD |
PMID:25284465 |
|
NCBI chr 6:106,605,611...106,739,208
Ensembl chr 6:106,605,621...106,721,412
|
|
G
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Smad3
|
SMAD family member 3
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multiple interactions
|
ISO
|
Ziram inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
|
CTD |
PMID:31652400 |
|
NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324
|
|
G
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Snca
|
synuclein alpha
|
increases expression
|
EXP
|
Ziram results in increased expression of SNCA protein
|
CTD |
PMID:18818210 |
|
NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315
|
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G
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Sod2
|
superoxide dismutase 2
|
increases expression
|
ISO
|
Ziram results in increased expression of SOD2 mRNA
|
CTD |
PMID:32712770 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
|
|
G
|
Sox9
|
SRY-box transcription factor 9
|
decreases expression
|
EXP
|
Ziram results in decreased expression of SOX9 mRNA; Ziram results in decreased expression of SOX9 protein
|
CTD |
PMID:29627606 |
|
NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250
|
|
G
|
Srd5a1
|
steroid 5 alpha-reductase 1
|
decreases expression decreases activity
|
EXP
|
Ziram results in decreased expression of SRD5A1 mRNA Ziram results in decreased activity of SRD5A1 protein
|
CTD |
PMID:28707553 PMID:30422632 |
|
NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:35,514,846...35,548,903
|
|
G
|
Star
|
steroidogenic acute regulatory protein
|
decreases expression affects expression
|
EXP
|
Ziram results in decreased expression of STAR mRNA; Ziram results in decreased expression of STAR protein Ziram affects the expression of STAR mRNA; Ziram affects the expression of STAR protein
|
CTD |
PMID:28973382 PMID:29627606 PMID:30422632 |
|
NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447
|
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G
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Sult1b1
|
sulfotransferase family 1B member 1
|
multiple interactions
|
ISO
|
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SULT1B1 mRNA
|
CTD |
PMID:32745781 |
|
NCBI chr14:20,771,917...20,784,665
Ensembl chr14:20,771,868...20,785,549
|
|
G
|
Tgfb1
|
transforming growth factor, beta 1
|
decreases activity multiple interactions
|
ISO
|
Ziram results in decreased activity of TGFB1 protein Ziram inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
|
CTD |
PMID:31652400 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
|
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G
|
Thrsp
|
thyroid hormone responsive
|
multiple interactions
|
ISO
|
[2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of THRSP mRNA; [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in decreased expression of THRSP mRNA; Dietary Fats inhibits the reaction [[2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of THRSP mRNA]
|
CTD |
PMID:32745781 |
|
NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:161,133,453...161,139,827
|
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G
|
Tnf
|
tumor necrosis factor
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multiple interactions
|
ISO
|
Ziram inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
|
CTD |
PMID:16112155 PMID:32712770 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
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G
|
Tpo
|
thyroid peroxidase
|
decreases activity
|
ISO
|
Ziram results in decreased activity of TPO protein
|
CTD |
PMID:9248629 |
|
NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:52,426,010...52,495,793
|
|
G
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Tspo
|
translocator protein
|
decreases expression
|
EXP
|
Ziram results in decreased expression of TSPO mRNA
|
CTD |
PMID:28973382 |
|
NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460
|
|
G
|
Uba1
|
ubiquitin-like modifier activating enzyme 1
|
decreases activity multiple interactions
|
ISO
|
Ziram results in decreased activity of UBA1 protein Trientine inhibits the reaction [Ziram results in decreased activity of and results in decreased ubiquitination of UBA1 protein]; Ziram results in decreased activity of and results in decreased ubiquitination of UBA1 protein
|
CTD |
PMID:18818210 PMID:25714994 |
|
NCBI chr X:1,508,700...1,530,677
Ensembl chr X:4,062,182...4,084,246
|
|