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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ziram
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Accession:CHEBI:79736 term browser browse the term
Definition:A dithiocarbamate salt that is the zinc salt of dimethyldithiocarbamic acid. It is a broad-spectrum fungicide and bird and animal repellent that is also used to accelerate the vulcanisation of rubber.
Synonyms:exact_synonym: zinc bis(dimethylcarbamodithioate)
 related_synonym: (T-4)-bis(dimethylcarbamodithioato-kappaS,kappaS')zinc;   Formula=C6H12N2S4Zn;   InChI=1S/2C3H7NS2.Zn/c2*1-4(2)3(5)6;/h2*1-2H3,(H,5,6);/q;;+2/p-2;   InChIKey=DUBNHZYBDBBJHD-UHFFFAOYSA-L;   SMILES=CN(C)C(=S)S[Zn]SC(=S)N(C)C;   bis(dimethylcarbamodithioato-S,S')zinc;   bis(dimethyldithiocarbamato)zinc;   bis-dimethyldithiocarbamate de zinc;   dimethyldithiocarbamate zinc salt;   zinc bis(dimethyldithiocarbamate);   zinc bis(dimethyldithiocarbamoyl)disulphide;   zinc bis(dimethylthiocarbamoyl)disulfide
 xref: CAS:137-30-4;   KEGG:C15229
 xref_mesh: MESH:D015039
 xref: PMID:16007644;   PMID:1842586;   PMID:18818210;   PMID:20842346;   PMID:22159898;   PMID:23298479;   PMID:24750788;   PMID:8478981;   Patent:US2492314;   Pesticides:ziram;   Reaxys:3707008;   Wikipedia:Ziram

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ziram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of ABCC2 mRNA CTD PMID:32745781 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of ABCC3 mRNA CTD PMID:32745781 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of ACOX1 mRNA CTD PMID:32736067 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation EXP Ziram results in decreased phosphorylation of AKT1 protein CTD PMID:30422632 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Amh anti-Mullerian hormone decreases expression
increases expression		 EXP Ziram results in decreased expression of AMH mRNA; Ziram results in decreased expression of AMH protein
Ziram results in increased expression of AMH mRNA		 CTD PMID:29627606, PMID:30422632 NCBI chr 7:11,775,155...11,777,503
Ensembl chr 7:11,775,155...11,777,503 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Ziram results in increased expression of BAX protein CTD PMID:28973382 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Ziram results in decreased expression of BCL2 protein CTD PMID:28973382 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO Acetylcysteine inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]; Dithiothreitol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]; Edetic Acid inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]; Mercaptoethanol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]; Ziram results in decreased expression of and results in increased degradation of CASP1 protein CTD PMID:25929180 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 increases activity ISO Ziram results in increased activity of CASP3 protein CTD PMID:20842346, PMID:22159898 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases activity ISO Ziram results in increased activity of CASP8 protein CTD PMID:22159898 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases activity ISO Ziram results in increased activity of CASP9 protein CTD PMID:22159898 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase increases expression ISO Ziram results in increased expression of CAT mRNA CTD PMID:32712770 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases secretion		 ISO Ziram inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
Ziram results in decreased secretion of CCL2 protein		 CTD PMID:32712770 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccnd3 cyclin D3 decreases expression EXP Ziram results in decreased expression of CCND3 mRNA CTD PMID:28973382 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression
decreases expression		 ISO Ziram results in increased expression of CCR2 mRNA
Ziram results in decreased expression of CCR2 protein		 CTD PMID:32712770
G Cd163 CD163 molecule decreases expression ISO Ziram results in decreased expression of CD163 mRNA; Ziram results in decreased expression of CD163 protein CTD PMID:32712770 NCBI chr 4:156,752,063...156,785,467
Ensembl chr 4:156,752,082...156,785,467 		JBrowse link
G Cd209 CD209 molecule increases expression ISO Ziram results in increased expression of CD209 mRNA; Ziram results in increased expression of CD209 protein CTD PMID:32712770 NCBI chr12:2,406,879...2,413,324
Ensembl chr12:2,406,879...2,413,324 		JBrowse link
G Cd36 CD36 molecule multiple interactions
decreases expression		 ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CD36 mRNA
Ziram results in decreased expression of CD36 mRNA; Ziram results in decreased expression of CD36 protein		 CTD PMID:32712770, PMID:32736067 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Clec7a C-type lectin domain containing 7A decreases expression ISO Ziram results in decreased expression of CLEC7A protein CTD PMID:32712770 NCBI chr 4:163,216,152...163,227,367
Ensembl chr 4:163,216,163...163,227,334 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CPT1A mRNA CTD PMID:32736067 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Ziram affects the localization of CYCS protein CTD PMID:20842346, PMID:22159898 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases activity
affects expression
decreases expression		 EXP Ziram results in decreased activity of CYP11A1 protein
Ziram affects the expression of CYP11A1 mRNA; Ziram affects the expression of CYP11A1 protein
Ziram results in decreased expression of CYP11A1 mRNA; Ziram results in decreased expression of CYP11A1 protein		 CTD PMID:28973382, PMID:29627606 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
affects expression
decreases activity		 EXP Ziram results in decreased expression of CYP17A1 mRNA; Ziram results in decreased expression of CYP17A1 protein
Ziram affects the expression of CYP17A1 mRNA; Ziram affects the expression of CYP17A1 protein
Ziram results in decreased activity of CYP17A1 protein		 CTD PMID:28973382, PMID:29627606, PMID:30422632 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2B10 mRNA; [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CYP2B10 mRNA CTD PMID:32736067, PMID:32745781 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2B9 mRNA CTD PMID:32745781 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CYP2C55 mRNA CTD PMID:32736067 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2C29 mRNA CTD PMID:32745781 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Dhh desert hedgehog signaling molecule decreases expression EXP Ziram results in decreased expression of DHH mRNA; Ziram results in decreased expression of DHH protein CTD PMID:29627606 NCBI chr 7:140,575,288...140,580,783
Ensembl chr 7:140,575,288...140,580,783 		JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of DIO1 mRNA CTD PMID:32745781 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520 		JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of ECI1 mRNA CTD PMID:32736067 NCBI chr10:13,797,573...13,810,918
Ensembl chr10:13,797,562...13,810,913 		JBrowse link
G Fcgr3a Fc fragment of IgG receptor IIIa decreases expression ISO Ziram results in decreased expression of FCGR3A protein CTD PMID:18670896 NCBI chr13:89,385,775...89,396,047
Ensembl chr13:89,385,859...89,396,051 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Ziram results in decreased expression of FSHB mRNA; Ziram results in decreased expression of FSHB protein CTD PMID:28973382, PMID:30422632 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131 		JBrowse link
G Fshr follicle stimulating hormone receptor decreases expression EXP Ziram results in decreased expression of FSHR mRNA; Ziram results in decreased expression of FSHR protein CTD PMID:29627606 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of GFAP protein CTD PMID:32736067 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Gzma granzyme A decreases expression ISO Ziram results in decreased expression of GZMA protein CTD PMID:22038140 NCBI chr 2:44,968,846...44,981,436
Ensembl chr 2:44,968,765...44,981,458 		JBrowse link
G Gzmb granzyme B decreases expression ISO Ziram results in decreased expression of GZMB protein CTD PMID:21859362, PMID:22038140 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316 		JBrowse link
G Gzmk granzyme K decreases expression ISO Ziram results in decreased expression of GZMK protein CTD PMID:22038140 NCBI chr 2:45,069,136...45,077,154
Ensembl chr 2:45,068,967...45,077,219 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of HMGCS2 mRNA CTD PMID:32745781 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Trientine inhibits the reaction [Ziram results in increased expression of HMOX1 protein]
Ziram results in increased expression of HMOX1 mRNA; Ziram results in increased expression of HMOX1 protein		 CTD PMID:25714994, PMID:32712770 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions
decreases expression
decreases activity		 EXP Ziram inhibits the reaction [[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone]; Ziram inhibits the reaction [HSD11B1 protein results in increased oxidation of NADP]; Ziram inhibits the reaction [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone]
Ziram results in decreased expression of HSD11B1 mRNA; Ziram results in decreased expression of HSD11B1 protein
Ziram results in decreased activity of HSD11B1 protein		 CTD PMID:26859423, PMID:28973382 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
decreases activity		 ISO
EXP		 Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein]; Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone]; Ziram inhibits the reaction [HSD11B2 protein results in increased oxidation of Hydrocortisone]; Ziram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD]
Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein]; Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone]; Ziram inhibits the reaction [HSD11B2 protein results in increased oxidation of Corticosterone]; Ziram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD]		 CTD PMID:26859423 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases activity
decreases expression		 EXP Ziram results in decreased activity of HSD17B3 protein
Ziram results in decreased expression of HSD17B3 mRNA; Ziram results in decreased expression of HSD17B3 protein		 CTD PMID:28973382, PMID:29627606, PMID:30422632 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases activity
decreases expression		 EXP Ziram results in decreased activity of HSD3B1 protein
Ziram results in decreased expression of HSD3B1 mRNA; Ziram results in decreased expression of HSD3B1 protein		 CTD PMID:28973382
G Ifnb1 interferon beta 1 multiple interactions ISO Ziram inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:18177342 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746 		JBrowse link
G Ifng interferon gamma increases expression ISO Ziram results in increased expression of IFNG protein CTD PMID:12062936 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Ziram inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Ziram inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]		 CTD PMID:25929180, PMID:32712770 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il4 interleukin 4 increases expression ISO Ziram results in increased expression of IL4 protein CTD PMID:12062936 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Ziram inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:32712770 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Insl3 insulin-like 3 decreases expression EXP Ziram results in decreased expression of INSL3 mRNA; Ziram results in decreased expression of INSL3 protein CTD PMID:29627606 NCBI chr16:20,120,753...20,122,702
Ensembl chr16:20,121,352...20,122,696 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Ziram results in increased expression of ITGAM mRNA; Ziram results in increased expression of ITGAM protein CTD PMID:32712770 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Lep leptin multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Lepr leptin receptor multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of LEPR mRNA CTD PMID:29321614 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression
affects expression		 EXP Ziram results in decreased expression of LHCGR mRNA; Ziram results in decreased expression of LHCGR protein
Ziram affects the expression of LHCGR mRNA; Ziram affects the expression of LHCGR protein		 CTD PMID:28973382, PMID:29627606, PMID:30422632 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity ISO Ziram results in increased activity of MAPK1 protein CTD PMID:21859362 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity ISO Ziram results in increased activity of MAPK3 protein CTD PMID:21859362 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mrc1 mannose receptor, C type 1 decreases expression ISO Ziram results in decreased expression of MRC1 protein CTD PMID:32712770 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects expression ISO Ziram affects the expression of NFE2L2 mRNA CTD PMID:32712770 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Ziram inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:17015962 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 decreases expression ISO Ziram results in decreased expression of NLRP3 protein CTD PMID:25929180 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Nmb neuromedin B multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of NMB mRNA CTD PMID:29321614 NCBI chr 1:142,721,263...142,724,646
Ensembl chr 1:142,721,002...142,724,511 		JBrowse link
G Nmbr neuromedin B receptor multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NMBR mRNA CTD PMID:29321614 NCBI chr 1:8,933,744...8,945,850
Ensembl chr 1:8,933,831...8,944,987 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 multiple interactions EXP [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NPY1R mRNA CTD PMID:29321614 NCBI chr16:24,779,480...24,789,131
Ensembl chr16:24,779,477...24,788,740 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the susceptibility to [2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with Thiophanate co-treated with thiacloprid co-treated with Ziram] CTD PMID:29950287 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression
affects expression		 EXP Ziram results in decreased expression of NR5A1 mRNA; Ziram results in decreased expression of NR5A1 protein
Ziram affects the expression of NR5A1 mRNA; Ziram affects the expression of NR5A1 protein		 CTD PMID:28973382, PMID:29627606 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of PDGFRB protein CTD PMID:32736067 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO Ziram affects the expression of PPARG mRNA CTD PMID:32712770 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression EXP Ziram results in decreased expression of PPARGC1A protein CTD PMID:30422632 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Prf1 perforin 1 decreases expression ISO Ziram results in decreased expression of PRF1 protein CTD PMID:21859362, PMID:22038140 NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
affects expression		 EXP Ziram results in decreased expression of SCARB1 mRNA; Ziram results in decreased expression of SCARB1 protein
Ziram affects the expression of SCARB1 mRNA; Ziram affects the expression of SCARB1 protein		 CTD PMID:28973382, PMID:29627606, PMID:30422632 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SERPINE1 mRNA CTD PMID:32745781 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Sirt1 sirtuin 1 decreases expression EXP Ziram results in decreased expression of SIRT1 protein CTD PMID:30422632 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SLC16A2 mRNA CTD PMID:32745781 NCBI chr  X:74,578,600...74,706,068
Ensembl chr  X:74,577,131...74,706,214 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO Ziram inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
G Snca synuclein alpha increases expression EXP Ziram results in increased expression of SNCA protein CTD PMID:18818210 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Ziram results in increased expression of SOD2 mRNA CTD PMID:32712770 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression EXP Ziram results in decreased expression of SOX9 mRNA; Ziram results in decreased expression of SOX9 protein CTD PMID:29627606 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression EXP Ziram results in decreased expression of SRD5A1 mRNA CTD PMID:30422632 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
affects expression		 EXP Ziram results in decreased expression of STAR mRNA; Ziram results in decreased expression of STAR protein
Ziram affects the expression of STAR mRNA; Ziram affects the expression of STAR protein		 CTD PMID:28973382, PMID:29627606, PMID:30422632 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SULT1B1 mRNA CTD PMID:32745781 NCBI chr14:22,142,412...22,155,246
Ensembl chr14:22,142,364...22,155,231 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity
multiple interactions		 ISO Ziram results in decreased activity of TGFB1 protein
Ziram inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]		 CTD PMID:31652400 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO [2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of THRSP mRNA; [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in decreased expression of THRSP mRNA; Dietary Fats inhibits the reaction [[2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of THRSP mRNA] CTD PMID:32745781 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ziram inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:16112155, PMID:32712770 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tpo thyroid peroxidase decreases activity ISO Ziram results in decreased activity of TPO protein CTD PMID:9248629 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855 		JBrowse link
G Tspo translocator protein decreases expression EXP Ziram results in decreased expression of TSPO mRNA CTD PMID:28973382 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609 		JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 decreases activity
multiple interactions		 ISO Ziram results in decreased activity of UBA1 protein
Trientine inhibits the reaction [Ziram results in decreased activity of and results in decreased ubiquitination of UBA1 protein]; Ziram results in decreased activity of and results in decreased ubiquitination of UBA1 protein		 CTD PMID:18818210, PMID:25714994 NCBI chr  X:1,723,135...1,745,147
Ensembl chr  X:1,723,174...1,741,701 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          apoptosis inducer 10979
            ziram 85
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  metal atom 17281
                    transition element atom 16730
                      d-block element atom 16720
                        zinc group element atom 10451
                          zinc atom 2696
                            zinc molecular entity 2696
                              elemental zinc 2393
                                zinc ion 479
                                  zinc cation 478
                                    zinc(2+) 478
                                      ziram 85
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.