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ONTOLOGY REPORT - ANNOTATIONS


Term:D-penicillamine
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Accession:CHEBI:7959 term browser browse the term
Definition:An optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning.
Synonyms:exact_synonym: (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid;   3-sulfanyl-D-valine
 related_synonym: (S)-2-amino-3-mercapto-3-methylbutanoic acid;   (S)-3,3-dimethylcysteine;   3-mercapto-D-valine;   Cuprimine;   D-Penamine;   D-beta,beta-dimethylcysteine;   Depen;   Formula=C5H11NO2S;   InChI=1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1;   InChIKey=VVNCNSJFMMFHPL-VKHMYHEASA-N;   PA;   SMILES=CC(C)(S)[C@@H](N)C(O)=O;   penicilamina;   penicillamine;   penicillaminum
 alt_id: CHEBI:469179
 xref: Beilstein:1722375 "Beilstein";   CAS:52-67-5 "ChemIDplus";   CAS:52-67-5 "KEGG COMPOUND";   CAS:52-67-5 "NIST Chemistry WebBook";   DrugBank:DB00859;   Drug_Central:2081 "DrugCentral";   HMDB:HMDB0014997;   KEGG:C07418;   KEGG:D00496
 xref_mesh: MESH:D010396
 xref: PDBeChem:LEI;   PMID:10408968 "Europe PMC";   PMID:13793949 "Europe PMC";   PMID:16736232 "Europe PMC";   PMID:1709917 "Europe PMC";   PMID:18570451 "Europe PMC";   PMID:19904729 "Europe PMC";   PMID:21989991 "Europe PMC";   PMID:22076732 "Europe PMC";   PMID:22151785 "Europe PMC";   PMID:22169274 "Europe PMC";   PMID:22683336 "Europe PMC";   PMID:23200399 "Europe PMC";   PMID:23342748 "Europe PMC";   PMID:23375251 "Europe PMC";   PMID:2420897 "Europe PMC";   PMID:7196231 "Europe PMC";   Reaxys:1722375 "Reaxys";   Wikipedia:Penicillamine
 cyclic_relationship: is_enantiomer_of CHEBI:50869


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D-penicillamine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahcy S-adenosylhomocysteine hydrolase JBrowse link 2 155,059,310 155,074,497 RGD:6480464
G Alox12 arachidonate 12-lipoxygenase JBrowse link 11 70,241,457 70,255,380 RGD:6480464
G Alox5ap arachidonate 5-lipoxygenase activating protein JBrowse link 5 149,265,004 149,288,153 RGD:6480464
G Anxa1 annexin A1 JBrowse link 19 20,373,434 20,390,671 RGD:6480464
G Anxa4 annexin A4 JBrowse link 6 86,736,840 86,793,634 RGD:6480464
G App amyloid beta (A4) precursor protein JBrowse link 16 84,952,666 85,175,255 RGD:6480464
G Atf6 activating transcription factor 6 JBrowse link 1 170,704,457 170,868,585 RGD:6480464
G Atp7a ATPase, Cu++ transporting, alpha polypeptide JBrowse link X 106,027,224 106,128,161 RGD:6480464
G Atp7b ATPase, Cu++ transporting, beta polypeptide JBrowse link 8 21,992,783 22,060,074 RGD:6480464
G Bbc3 BCL2 binding component 3 JBrowse link 7 16,308,398 16,318,334 RGD:6480464
G Bcl2 B cell leukemia/lymphoma 2 JBrowse link 1 106,538,176 106,714,290 RGD:6480464
G Bid BH3 interacting domain death agonist JBrowse link 6 120,893,119 120,917,062 RGD:6480464
G C1s2 complement component 1, s subcomponent 2 JBrowse link 6 124,624,625 124,636,085 RGD:6480464
G C3 complement component 3 JBrowse link 17 57,203,967 57,228,136 RGD:6480464
G C4a complement component 4A (Rodgers blood group) JBrowse link 17 34,809,092 34,823,460 RGD:6480464
G C4b complement component 4B (Chido blood group) JBrowse link 17 34,728,139 34,743,902 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Casp9 caspase 9 JBrowse link 4 141,793,612 141,815,978 RGD:6480464
G Cat catalase JBrowse link 2 103,453,904 103,485,153 RGD:6480464
G Ccl3 chemokine (C-C motif) ligand 3 JBrowse link 11 83,647,843 83,649,378 RGD:6480464
G Ccl4 chemokine (C-C motif) ligand 4 JBrowse link 11 83,648,624 83,664,683 RGD:6480464
G Ccl5 chemokine (C-C motif) ligand 5 JBrowse link 11 83,525,778 83,530,518 RGD:6480464
G Ccr5 chemokine (C-C motif) receptor 5 JBrowse link 9 124,121,543 124,127,183 RGD:6480464
G Cd14 CD14 antigen JBrowse link 18 36,725,064 36,726,815 RGD:6480464
G Cd163 CD163 antigen JBrowse link 6 124,304,636 124,330,529 RGD:6480464
G Cd38 CD38 antigen JBrowse link 5 43,868,809 43,912,374 RGD:6480464
G Cd52 CD52 antigen JBrowse link 4 134,093,538 134,095,073 RGD:6480464
G Clu clusterin JBrowse link 14 65,968,483 65,981,548 RGD:6480464
G Cp ceruloplasmin JBrowse link 3 19,956,933 20,009,750 RGD:6480464
G Cpt1a carnitine palmitoyltransferase 1a, liver JBrowse link 19 3,322,326 3,385,735 RGD:6480464
G Crp C-reactive protein, pentraxin-related JBrowse link 1 172,698,056 172,699,966 RGD:6480464
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) JBrowse link 11 54,247,270 54,249,899 RGD:6480464
G Cxcr4 chemokine (C-X-C motif) receptor 4 JBrowse link 1 128,588,199 128,592,299 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 9 57,687,928 57,703,824 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 7 140,763,819 140,774,990 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 10 127,290,793 127,296,291 RGD:6480464
G Dnmt3a DNA methyltransferase 3A JBrowse link 12 3,801,559 3,914,443 RGD:6480464
G Dnmt3b DNA methyltransferase 3B JBrowse link 2 153,649,411 153,687,730 RGD:6480464
G Dusp1 dual specificity phosphatase 1 JBrowse link 17 26,505,591 26,508,472 RGD:6480464
G Dusp6 dual specificity phosphatase 6 JBrowse link 10 99,263,231 99,267,489 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 34,861,207 34,864,956 RGD:6480464
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 6 70,844,484 70,905,241 RGD:6480464
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha JBrowse link 12 78,862,072 78,887,010 RGD:6480464
G Eln elastin JBrowse link 5 134,702,595 134,747,368 RGD:6480464
G Fcnb ficolin B JBrowse link 2 28,076,479 28,084,910 RGD:6480464
G Fmo1 flavin containing monooxygenase 1 JBrowse link 1 162,829,561 162,866,610 RGD:6480464
G Fmo5 flavin containing monooxygenase 5 JBrowse link 3 97,609,938 97,655,287 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 1 71,585,473 71,653,280 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha JBrowse link 6 67,035,096 67,037,407 RGD:6480464
G Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) JBrowse link 2 122,594,473 122,611,277 RGD:6480464
G Gstm5 glutathione S-transferase, mu 5 JBrowse link 3 107,895,854 107,898,685 RGD:6480464
G H2-Eb1 histocompatibility 2, class II antigen E beta JBrowse link 17 34,305,867 34,316,674 RGD:6480464
G H2-M2 histocompatibility 2, M region locus 2 JBrowse link 17 37,480,851 37,483,554 RGD:6480464
G H2-Q1 histocompatibility 2, Q region locus 1 JBrowse link 17 35,320,525 35,328,142 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Hp haptoglobin JBrowse link 8 109,575,128 109,579,172 RGD:6480464
G Hspa1a heat shock protein 1A JBrowse link 17 34,969,359 34,972,156 RGD:6480464
G Hspa1l heat shock protein 1-like JBrowse link 17 34,972,703 34,979,228 RGD:6480464
G Hspa2 heat shock protein 2 JBrowse link 12 76,403,812 76,406,938 RGD:6480464
G Hspa5 heat shock protein 5 JBrowse link 2 34,772,090 34,776,529 RGD:6480464
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:6480464
G Igf1 insulin-like growth factor 1 JBrowse link 10 87,858,265 87,937,047 RGD:6480464
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:6480464
G Il13 interleukin 13 JBrowse link 11 53,631,323 53,634,702 RGD:6480464
G Il15 interleukin 15 JBrowse link 8 82,331,624 82,403,252 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il21 interleukin 21 JBrowse link 3 37,222,759 37,232,636 RGD:6480464
G Il23a interleukin 23, alpha subunit p19 JBrowse link 10 128,296,140 128,298,084 RGD:6480464
G Il3ra interleukin 3 receptor, alpha chain JBrowse link 14 14,345,912 14,355,493 RGD:6480464
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Klf4 Kruppel-like factor 4 (gut) JBrowse link 4 55,527,137 55,532,475 RGD:6480464
G Lgals1 lectin, galactose binding, soluble 1 JBrowse link 15 78,926,725 78,930,465 RGD:6480464
G Loxl2 lysyl oxidase-like 2 JBrowse link 14 69,608,692 69,695,834 RGD:6480464
G Mcl1 myeloid cell leukemia sequence 1 JBrowse link 3 95,656,944 95,663,179 RGD:6480464
G Mpo myeloperoxidase JBrowse link 11 87,793,784 87,804,412 RGD:6480464
G Mt1 metallothionein 1 JBrowse link 8 94,178,883 94,180,327 RGD:6480464
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 13 12,181,331 12,258,199 RGD:6480464
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 JBrowse link 2 75,675,513 75,704,663 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 JBrowse link 15 101,253,902 101,274,795 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase family, member 1 JBrowse link 1 180,568,891 180,600,999 RGD:6480464
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 66,458,604 66,465,558 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 15 85,734,910 85,806,851 RGD:6480464
G Prl prolactin JBrowse link 13 27,057,570 27,065,204 RGD:6480464
G Ptger2 prostaglandin E receptor 2 (subtype EP2) JBrowse link 14 44,988,111 45,003,820 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 2 36,216,742 36,258,593 RGD:6480464
G S100a4 S100 calcium binding protein A4 JBrowse link 3 90,603,770 90,606,045 RGD:6480464
G S100a6 S100 calcium binding protein A6 (calcyclin) JBrowse link 3 90,612,894 90,614,414 RGD:6480464
G S100a8 S100 calcium binding protein A8 (calgranulin A) JBrowse link 3 90,669,071 90,670,034 RGD:6480464
G S100a9 S100 calcium binding protein A9 (calgranulin B) JBrowse link 3 90,692,630 90,695,721 RGD:6480464
G Selenbp1 selenium binding protein 1 JBrowse link 3 94,933,083 94,944,758 RGD:6480464
G Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 JBrowse link 1 74,375,014 74,386,057 RGD:6480464
G Slc28a2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 JBrowse link 2 122,426,355 122,461,152 RGD:6480464
G Slc30a1 solute carrier family 30 (zinc transporter), member 1 JBrowse link 1 191,906,697 191,913,248 RGD:6480464
G Slc31a1 solute carrier family 31, member 1 JBrowse link 4 62,360,583 62,391,769 RGD:6480464
G Slc4a1 solute carrier family 4 (anion exchanger), member 1 JBrowse link 11 102,348,820 102,365,281 RGD:6480464
G Sod1 superoxide dismutase 1, soluble JBrowse link 16 90,220,762 90,226,333 RGD:6480464
G Sp1 trans-acting transcription factor 1 JBrowse link 15 102,406,316 102,436,404 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 11 60,199,084 60,224,186 RGD:6480464
G Stx3 syntaxin 3 JBrowse link 19 11,775,118 11,821,569 RGD:6480464
G Tfrc transferrin receptor JBrowse link 16 32,608,896 32,632,794 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:6480464
G Xbp1 X-box binding protein 1 JBrowse link 11 5,520,641 5,525,993 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20752
    role 20730
      chemical role 20154
        ligand 5800
          chelator 5784
            D-penicillamine 105
              benzylpenillamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20752
    subatomic particle 20745
      composite particle 20745
        hadron 20745
          baryon 20745
            nucleon 20745
              atomic nucleus 20745
                atom 20745
                  main group element atom 20665
                    p-block element atom 20665
                      carbon group element atom 20401
                        carbon atom 20377
                          organic molecular entity 20377
                            organic group 19045
                              organic divalent group 19034
                                organodiyl group 19034
                                  carbonyl group 19007
                                    carbonyl compound 19007
                                      carboxylic acid 18675
                                        amino acid 12533
                                          alpha-amino acid 7566
                                            non-proteinogenic alpha-amino acid 1532
                                              penicillamine 105
                                                D-penicillamine 105
                                                  benzylpenillamine 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.