Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pemoline
go back to main search page
Accession:CHEBI:7953 term browser browse the term
Definition:A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.
Synonyms:exact_synonym: 2-amino-5-phenyl-1,3-oxazol-4(5H)-one
 related_synonym: 2-Amino-5-phenyl-4(5H)-oxazolone;   2-imino-4-keto-5-phenyltetrahydrooxazole;   5-phenyl-2-imino-4-oxazolidinone;   5-phenyl-2-imino-4-oxooxazolidine;   5-phenylisohydantion;   Azoxodon;   Betanamin;   Cylert;   Dantromin;   Deltamine;   Formula=C9H8N2O2;   Hyton;   InChI=1S/C9H8N2O2/c10-9-11-8(12)7(13-9)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12);   InChIKey=NRNCYVBFPDDJNE-UHFFFAOYSA-N;   Myamin;   Nitan;   Notair;   SMILES=NC1=NC(=O)C(O1)c1ccccc1;   pemolina;   pemolinum;   pheniminooxazolidinone;   phenylisohydantoin;   phenylpseudohydantoin
 xref: CAS:2152-34-3;   DrugBank:DB01230;   Drug_Central:2075;   KEGG:C07899;   KEGG:D00744;   LINCS:LSM-5159;   PMID:11216184;   PMID:2210262;   PMID:2303976;   PMID:2388127;   PMID:4021028;   PMID:641739;   PMID:772696;   Reaxys:151559;   Wikipedia:Pemoline


show annotations for term's descendants           Sort by:
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5066
    role 5030
      application 869
        pharmaceutical 719
          drug 719
            central nervous system drug 163
              central nervous system stimulant 2
                pemoline 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5066
    subatomic particle 5057
      composite particle 5057
        hadron 5057
          baryon 5057
            nucleon 5057
              atomic nucleus 5057
                atom 5057
                  main group element atom 5026
                    p-block element atom 5023
                      carbon group element atom 4940
                        carbon atom 4939
                          organic molecular entity 4939
                            organic molecule 4887
                              organic cyclic compound 4825
                                organic heterocyclic compound 4614
                                  heteroarene 135
                                    monocyclic heteroarene 33
                                      azole 33
                                        oxazole 4
                                          1,3-oxazoles 0
                                            pemoline 0
paths to the root