Nonylphenol - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	Nonylphenol	go back to main search page
Accession:	CHEBI:79516	browse the term
Synonyms:	xref:	CAS:25154-52-3; KEGG:C14993
	xref_mesh:	MESH:C025256

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Rat (297) Mouse (299) Human (295) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (297)

Nonylphenol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression

nonylphenol results in increased expression of ABCB1A mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

increases expression

nonylphenol results in increased expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

acetylcholinesterase

multiple interactions

[nonylphenol co-treated with octylphenol] affects the expression of and results in increased activity of ACHE protein; lycium barbarum polysaccharide inhibits the reaction [[nonylphenol co-treated with octylphenol] affects the expression of and results in increased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acid phosphatase 5, tartrate resistant

decreases expression

nonylphenol results in decreased expression of ACP5 protein

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

actin, beta

increases expression

nonylphenol results in increased expression of ACTB protein

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin related protein 1A

increases expression

nonylphenol results in increased expression of ACTR1A protein

NCBI chr 1:245,237,821...245,256,618
Ensembl chr 1:245,237,826...245,256,495

G

adiponectin, C1Q and collagen domain containing

affects expression
increases expression

nonylphenol affects the expression of ADIPOQ mRNA
nonylphenol results in increased expression of ADIPOQ mRNA

PMID:17010207 PMID:18417718

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adrenoceptor alpha 2C

decreases expression

nonylphenol results in decreased expression of ADRA2C mRNA

NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846

G

adenosylhomocysteinase

decreases expression

nonylphenol results in decreased expression of AHCY protein

NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393

G

aryl hydrocarbon receptor

multiple interactions
increases expression

nonylphenol inhibits the reaction [AHR protein binds to CYP1A1 promoter]
AHR protein affects the reaction [nonylphenol results in decreased expression of and results in decreased acetylation of HNF4A protein]; AHR protein affects the reaction [nonylphenol results in decreased expression of and results in decreased secretion of TNFSF15 protein]; AHR protein affects the reaction [nonylphenol results in decreased expression of TNFSF15 mRNA]; AHR protein affects the reaction [nonylphenol results in increased expression of HDAC2 mRNA]; AHR protein affects the reaction [nonylphenol results in increased expression of HDAC2 protein]; AHR protein affects the reaction [nonylphenol results in increased expression of PECAM1 protein]
nonylphenol results in increased expression of AHR mRNA; nonylphenol results in increased expression of AHR protein

PMID:11248424 PMID:34974051

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

allograft inflammatory factor 1

increases expression

nonylphenol results in increased expression of AIF1 protein

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

AKT serine/threonine kinase 1

decreases expression
increases phosphorylation

nonylphenol results in decreased expression of AKT1 mRNA
nonylphenol results in increased phosphorylation of AKT1 protein

PMID:27832966 PMID:29484677 PMID:33516137

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

5'-aminolevulinate synthase 1

increases expression

nonylphenol results in increased expression of ALAS1 mRNA

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

aldehyde dehydrogenase 5 family, member A1

increases expression

nonylphenol results in increased expression of ALDH5A1 mRNA

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

G

alkaline phosphatase, biomineralization associated

multiple interactions

[nonylphenol binds to ESR1 protein] which results in increased activity of ALPL protein

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

annexin A3

increases expression

nonylphenol results in increased expression of ANXA3 protein

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

G

annexin A7

decreases expression

nonylphenol results in decreased expression of ANXA7 protein

NCBI chr15:3,821,798...3,849,659
Ensembl chr15:3,821,845...3,849,385

G

acylaminoacyl-peptide hydrolase

increases expression

nonylphenol results in increased expression of APEH mRNA

NCBI chr 8:108,773,791...108,782,903
Ensembl chr 8:108,773,794...108,782,933

G

apolipoprotein B

increases expression

nonylphenol results in increased expression of APOB mRNA

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

androgen receptor

increases expression
multiple interactions
decreases activity
decreases expression
affects binding

nonylphenol results in increased expression of AR mRNA
nonylphenol inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; nonylphenol inhibits the reaction [Metribolone results in increased activity of AR protein]
nonylphenol results in decreased activity of AR protein
nonylphenol analog results in decreased expression of AR mRNA
nonylphenol binds to AR protein
nonylphenol inhibits the reaction [Dihydrotestosterone binds to AR protein]

PMID:12805653 PMID:14565775 PMID:15159206 PMID:20371976 PMID:25242005 More...

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

Rho GDP dissociation inhibitor alpha

decreases expression

nonylphenol results in decreased expression of ARHGDIA mRNA

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

G

actin related protein 2/3 complex, subunit 2

decreases expression

nonylphenol results in decreased expression of ARPC2 protein

NCBI chr 9:75,820,782...75,851,471
Ensembl chr 9:75,820,770...75,851,471

G

ATP synthase F1 subunit beta

increases expression

nonylphenol results in increased expression of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase peripheral stalk subunit OSCP

increases expression

nonylphenol results in increased expression of ATP5PO mRNA

NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592

G

ATPase H+ transporting accessory protein 1

increases expression

nonylphenol results in increased expression of ATP6AP1 mRNA

NCBI chr X:152,079,954...152,087,034
Ensembl chr X:152,079,865...152,087,034

G

arginine vasopressin receptor 1B

decreases expression

nonylphenol results in decreased expression of AVPR1B mRNA

NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792

G

arginine vasopressin receptor 2

decreases expression

nonylphenol results in decreased expression of AVPR2 mRNA

NCBI chr X:151,633,501...151,636,155
Ensembl chr X:151,633,522...151,635,989

G

BCL2 associated X, apoptosis regulator

increases expression

nonylphenol results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

increases expression
decreases expression

nonylphenol results in increased expression of BCL2 protein
nonylphenol results in decreased expression of BCL2 protein

PMID:23677851 PMID:24604882

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

brain-derived neurotrophic factor

multiple interactions
decreases expression
decreases response to substance

[BDNF protein results in decreased susceptibility to nonylphenol] which results in increased expression of CREB1 protein; [BDNF protein results in decreased susceptibility to nonylphenol] which results in increased expression of CREB1 protein modified form; [BDNF protein results in decreased susceptibility to nonylphenol] which results in increased expression of NTRK2 protein; BDNF protein inhibits the reaction [nonylphenol results in decreased expression of NTRK2 protein modified form]
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased expression of BDNF protein]; [nonylphenol co-treated with octylphenol] results in decreased expression of BDNF protein; Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased phosphorylation of BDNF protein]; lycium barbarum polysaccharide inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased phosphorylation of BDNF protein]
nonylphenol results in decreased expression of BDNF mRNA; nonylphenol results in decreased expression of BDNF protein

PMID:35662570 PMID:38642822

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

biliverdin reductase B

increases expression

nonylphenol results in increased expression of BLVRB protein

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

complement C3

increases expression

nonylphenol results in increased expression of C3 protein
nonylphenol results in increased expression of C3 mRNA; nonylphenol results in increased expression of C3 protein

PMID:11086226 PMID:11390168

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

capping actin protein of muscle Z-line subunit beta

decreases expression

nonylphenol results in decreased expression of CAPZB protein

NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409

G

caspase 1

increases expression
multiple interactions

nonylphenol results in increased expression of CASP1 mRNA; nonylphenol results in increased expression of CASP1 protein
nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of and results in increased cleavage of CASP1 protein]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of CASP1 mRNA]

PMID:35998786 PMID:38176579

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

increases expression
multiple interactions
increases cleavage
decreases expression

nonylphenol results in increased expression of CASP3 protein; nonylphenol results in increased expression of CASP3 protein modified form
thymoquinone inhibits the reaction [nonylphenol results in increased expression of CASP3 protein]
Acetylcysteine affects the reaction [nonylphenol results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [nonylphenol results in increased cleavage of CASP3 protein]
nonylphenol results in decreased expression of CASP3 protein

PMID:17065434 PMID:23677851 PMID:27832966 PMID:37466128

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

calcium-sensing receptor

decreases expression

nonylphenol results in decreased expression of CASR mRNA

NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811

G

catalase

decreases activity

nonylphenol results in decreased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

Fulvestrant inhibits the reaction [nonylphenol inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]]; nonylphenol inhibits the reaction [IL1A protein promotes the reaction [[RELA protein binds to NFKB1 protein] which binds to CCL2 promoter]]; nonylphenol inhibits the reaction [IL1A protein results in increased expression of CCL2 mRNA]; nonylphenol inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]; nonylphenol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]

PMID:10614622 PMID:36416909

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

nonylphenol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

cellular communication network factor 5

increases expression

nonylphenol results in increased expression of CCN5 mRNA

NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636

G

cyclin D1

multiple interactions
increases expression

[nonylphenol co-treated with Resveratrol] results in decreased expression of CCND1 mRNA; Fulvestrant inhibits the reaction [nonylphenol results in increased expression of CCND1 mRNA]
nonylphenol results in increased expression of CCND1 mRNA; nonylphenol results in increased expression of CCND1 protein

PMID:22552626 PMID:27260121 PMID:27366082 PMID:33516137

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

increases expression

nonylphenol results in increased expression of CCNE1 mRNA

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin E2

increases expression

nonylphenol results in increased expression of CCNE2 mRNA; nonylphenol results in increased expression of CCNE2 protein

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cadherin 1

decreases expression
multiple interactions

nonylphenol results in decreased expression of CDH1 protein
fulvestrant inhibits the reaction [nonylphenol results in decreased expression of CDH1 protein]; Genistein inhibits the reaction [nonylphenol results in decreased expression of CDH1 protein]

PMID:25690688 PMID:26407941

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

decreases expression
affects expression
increases expression

nonylphenol analog results in decreased expression of CDH2 mRNA
nonylphenol affects the expression of CDH2 mRNA
nonylphenol results in decreased expression of CDH2 protein
nonylphenol analog results in increased expression of CDH2 mRNA

PMID:25242005 PMID:27832966

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin dependent kinase 2

multiple interactions
increases expression

[nonylphenol co-treated with resveratrol] results in decreased expression of CDK2 mRNA
nonylphenol results in increased expression of CDK2 mRNA

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

glycoprotein hormones, alpha polypeptide

multiple interactions

nonylphenol affects the reaction [CGA protein results in increased expression of CYP11A1 protein]; nonylphenol affects the reaction [CGA protein results in increased expression of STAR protein]; nonylphenol inhibits the reaction [CGA protein results in increased secretion of Testosterone]

NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191

G

cholinergic receptor, muscarinic 2

decreases expression

nonylphenol results in decreased expression of CHRM2 mRNA

NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103

G

claudin 1

decreases expression

nonylphenol results in decreased expression of CLDN1 protein

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

clusterin

decreases expression

nonylphenol results in decreased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

chemerin chemokine-like receptor 2

increases expression

nonylphenol results in increased expression of CMKLR2 mRNA

NCBI chr 9:64,583,310...64,617,883
Ensembl chr 9:64,585,594...64,586,655

G

cannabinoid receptor 1

decreases expression

nonylphenol results in decreased expression of CNR1 mRNA

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

carnitine palmitoyltransferase 1A

decreases expression

nonylphenol results in decreased expression of CPT1A protein

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

cAMP responsive element binding protein 1

multiple interactions
decreases expression

[BDNF protein results in decreased susceptibility to nonylphenol] which results in increased expression of CREB1 protein; [BDNF protein results in decreased susceptibility to nonylphenol] which results in increased expression of CREB1 protein modified form; nonylphenol results in increased phosphorylation of and results in increased localization of and results in increased activity of CREB1 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased phosphorylation of CREB1 protein]; [nonylphenol co-treated with octylphenol] results in decreased phosphorylation of CREB1 protein; Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased phosphorylation of CREB1 protein]; lycium barbarum polysaccharide inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased phosphorylation of CREB1 protein]
nonylphenol results in decreased expression of CREB1 mRNA; nonylphenol results in decreased expression of CREB1 protein; nonylphenol results in decreased expression of CREB1 protein modified form

PMID:20954072 PMID:35662570 PMID:38642822

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cytokine receptor-like factor 2

multiple interactions

nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of CRLF2 mRNA]; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of CRLF2 protein]

NCBI chr14:103,943...108,643
Ensembl chr14:103,939...108,642

G

cathepsin D

multiple interactions
increases expression

[nonylphenol results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; ESR1 protein promotes the reaction [nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]]; fulvestrant inhibits the reaction [nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]]; fulvestrant inhibits the reaction [nonylphenol results in increased expression of CTSD protein]; Genistein inhibits the reaction [nonylphenol results in increased expression of CTSD protein]; nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]; nonylphenol promotes the reaction [NCOA1 protein binds to CTSD promoter]

PMID:14754635 PMID:26407941 PMID:27366082

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

C-X-C motif chemokine ligand 10

increases expression

nonylphenol results in increased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions
decreases expression

nonylphenol affects the reaction [CGA protein results in increased expression of CYP11A1 protein]
nonylphenol analog results in decreased expression of CYP11A1 mRNA

PMID:19883722 PMID:22771390

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
increases activity
decreases activity

[Dichlorodiphenyl Dichloroethylene co-treated with nonylphenol] results in increased activity of CYP19A1 protein; bis(tri-n-butyltin)oxide promotes the reaction [nonylphenol results in decreased activity of CYP19A1 protein]; bisphenol A promotes the reaction [nonylphenol results in decreased activity of CYP19A1 protein]; Chlordecone promotes the reaction [nonylphenol results in decreased activity of CYP19A1 protein]; nonylphenol promotes the reaction [bis(tri-n-butyltin)oxide results in decreased activity of CYP19A1 protein]; nonylphenol promotes the reaction [bisphenol A results in decreased activity of CYP19A1 protein]; nonylphenol promotes the reaction [Chlordecone results in decreased activity of CYP19A1 protein]
nonylphenol results in increased activity of CYP19A1 protein

PMID:17599374 PMID:27825933

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

nonylphenol inhibits the reaction [AHR protein binds to CYP1A1 promoter]; nonylphenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; nonylphenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
nonylphenol results in increased expression of CYP1A1 mRNA; nonylphenol results in increased expression of CYP1A1 protein

PMID:11248424 PMID:34974051

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

nonylphenol results in increased expression of CYP1A2 mRNA; nonylphenol results in increased expression of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

nonylphenol results in increased expression of CYP1B1 mRNA; nonylphenol results in increased expression of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 26, subfamily a, polypeptide 1

increases expression

nonylphenol results in increased expression of CYP26A1 mRNA

NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases metabolic processing
multiple interactions
increases expression

CYP2B6 results in increased metabolism of nonylphenol
NR1I3 gene mutant form affects the reaction [nonylphenol results in increased expression of CYP2B10 mRNA]

PMID:9817083 PMID:19041682

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

decreases activity
decreases expression

nonylphenol results in decreased activity of CYP2C11 protein
nonylphenol results in decreased expression of CYP2C11 protein

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
increases expression

NR1I3 gene mutant form affects the reaction [nonylphenol results in increased expression of CYP2C29 mRNA]

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

nonylphenol results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

deleted in azoospermia-like

increases expression

nonylphenol results in increased expression of DAZL mRNA

NCBI chr 9:10,695,593...10,712,330
Ensembl chr 9:10,695,592...10,712,323

G

DNA-damage inducible transcript 3

increases expression

nonylphenol results in increased expression of DDIT3 mRNA; nonylphenol results in increased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEAD-box helicase 4

increases expression

nonylphenol results in increased expression of DDX4 mRNA

NCBI chr 2:44,227,946...44,282,867
Ensembl chr 2:44,227,946...44,282,723

G

desmin

increases expression

nonylphenol results in increased expression of DES protein

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

dihydrolipoamide dehydrogenase

decreases expression

nonylphenol results in decreased expression of DLD protein

NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795

G

DNA meiotic recombinase 1

increases expression

nonylphenol results in increased expression of DMC1 mRNA

NCBI chr 7:111,124,888...111,167,465
Ensembl chr 7:111,124,888...111,167,952

G

doublesex and mab-3 related transcription factor 1

increases expression

nonylphenol results in increased expression of DMRT1 mRNA

NCBI chr 1:223,142,859...223,241,333
Ensembl chr 1:223,142,859...223,241,333

G

developmental pluripotency-associated 3

increases expression

nonylphenol results in increased expression of DPPA3 mRNA

NCBI chr 4:155,851,461...155,854,845
Ensembl chr 4:155,815,296...155,854,861
Ensembl chr 5:155,815,296...155,854,861

G

dopamine receptor D1

decreases expression

nonylphenol results in decreased expression of DRD1 mRNA

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

increases expression

nonylphenol results in increased expression of DRD2 mRNA

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

desmoplakin

increases expression

nonylphenol results in increased expression of DSP protein

NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800

G

E2F transcription factor 1

increases expression

nonylphenol results in increased expression of E2F1 mRNA; nonylphenol results in increased expression of E2F1 protein

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

endothelin receptor type B

increases expression

nonylphenol results in increased expression of EDNRB mRNA

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

early growth response 3

increases expression

nonylphenol results in increased expression of EGR3 mRNA

NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627

G

enolase 1

decreases expression

nonylphenol results in decreased expression of ENO1 protein

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

G

enolase 2

decreases expression

nonylphenol results in decreased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

Eph receptor A8

increases expression

nonylphenol results in increased expression of EPHA8 mRNA

NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399

G

epiregulin

increases expression

nonylphenol results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

endoplasmic reticulum protein 29

decreases expression

nonylphenol results in decreased expression of ERP29 protein

NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376

G

estrogen receptor 1

affects activity
affects localization
increases expression
multiple interactions
decreases expression
increases activity
affects binding

nonylphenol affects the activity of ESR1 protein
nonylphenol affects the localization of ESR1 protein
nonylphenol results in increased expression of ESR1 mRNA
[nonylphenol binds to ESR1 protein] which results in increased activity of ALPL protein; [nonylphenol results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; [nonylphenol results in increased activity of ESR1 protein] which results in increased expression of TFF1 mRNA; afimoxifene inhibits the reaction [nonylphenol results in increased activity of ESR1 protein]; ESR1 protein promotes the reaction [nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]]; Fulvestrant inhibits the reaction [nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]]; nonylphenol analog inhibits the reaction [Estradiol binds to ESR1 protein]; nonylphenol analog inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; nonylphenol binds to and results in increased activity of ESR1 protein; nonylphenol inhibits the reaction [Estradiol binds to ESR1 protein]; nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]; nonylphenol results in increased activity of and results in increased localization of ESR1 protein; TGFB3 protein inhibits the reaction [nonylphenol results in increased expression of ESR1 mRNA]
nonylphenol analog results in increased expression of ESR1 mRNA; nonylphenol analog results in increased expression of ESR1 protein
nonylphenol analog results in decreased expression of ESR1 mRNA; nonylphenol analog results in decreased expression of ESR1 protein
nonylphenol results in increased expression of ESR1 mRNA; nonylphenol results in increased expression of ESR1 protein
nonylphenol analog results in increased activity of ESR1 protein; nonylphenol results in increased activity of ESR1 protein
nonylphenol results in decreased expression of ESR1 mRNA; nonylphenol results in decreased expression of ESR1 protein
nonylphenol analog binds to ESR1 protein; nonylphenol binds to ESR1 protein; nonylphenol metabolite binds to ESR1 protein

PMID:9751507 PMID:10492897 PMID:11086226 PMID:11731036 PMID:12062901 More...

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases activity
increases expression
multiple interactions
affects binding

nonylphenol results in increased activity of ESR2 protein
nonylphenol results in increased expression of ESR2 protein
nonylphenol binds to and results in increased activity of ESR2 protein; Sodium Hypochlorite inhibits the reaction [nonylphenol binds to ESR2 protein]

PMID:9751507 PMID:14709801 PMID:14723943 PMID:14754635 PMID:16756374 More...

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

estrogen-related receptor beta

increases expression

nonylphenol results in increased expression of ESRRB mRNA

NCBI chr 6:106,007,701...106,163,136
Ensembl chr 6:106,008,095...106,160,791

G

F2R like trypsin receptor 1

decreases expression

nonylphenol results in decreased expression of F2RL1 mRNA

NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression
increases expression

TGFB3 protein inhibits the reaction [nonylphenol results in increased expression of FOS mRNA]
nonylphenol results in decreased expression of FOS mRNA

PMID:26224478 PMID:32645552

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

follicle stimulating hormone receptor

increases expression
decreases expression

nonylphenol analog results in increased expression of FSHR protein
nonylphenol results in decreased expression of FSHR protein
nonylphenol results in increased expression of FSHR mRNA

PMID:25242005 PMID:27832966

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

glucose-6-phosphate dehydrogenase

decreases expression

nonylphenol results in decreased expression of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glutamate decarboxylase 1

increases expression

nonylphenol results in increased expression of GAD1 mRNA

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

glutamate decarboxylase 2

decreases expression

nonylphenol results in decreased expression of GAD2 mRNA

NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155

G

galanin receptor 1

decreases expression

nonylphenol results in decreased expression of GALR1 mRNA

NCBI chr18:75,772,021...75,787,577
Ensembl chr18:75,772,023...75,787,577

G

galanin receptor 2

decreases expression

nonylphenol results in decreased expression of GALR2 mRNA

PMID:15518916 PMID:15620428

NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176

G

GATA binding protein 3

multiple interactions

nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of GATA3 mRNA]

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

glucokinase

decreases expression

nonylphenol results in decreased expression of GCK mRNA

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

GDP dissociation inhibitor 2

increases expression

nonylphenol results in increased expression of GDI2 protein

NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366

G

glial fibrillary acidic protein

multiple interactions
increases expression

thymoquinone inhibits the reaction [nonylphenol results in increased expression of GFAP protein]

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

growth hormone releasing hormone

increases expression

nonylphenol results in increased expression of GHRH mRNA

NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889

G

glycerol-3-phosphate dehydrogenase 1

decreases expression

nonylphenol results in decreased expression of GPD1 protein

NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529

G

G protein-coupled estrogen receptor 1

multiple interactions
decreases expression
increases activity

nonylphenol binds to and results in increased activity of GPER1 protein
nonylphenol results in decreased expression of GPER1 mRNA
nonylphenol results in increased activity of GPER1 protein

PMID:15620428 PMID:17088055 PMID:24604882

NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889

G

G protein-coupled receptor 19

decreases expression

nonylphenol results in decreased expression of GPR19 mRNA

NCBI chr 4:167,710,944...167,739,232
Ensembl chr 4:167,710,666...167,741,036

G

glutathione peroxidase 1

decreases expression

nonylphenol results in decreased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 4

increases expression

nonylphenol results in increased expression of GPX4 mRNA

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

glutamate ionotropic receptor NMDA type subunit 1

decreases expression

nonylphenol results in decreased expression of GRIN1 mRNA

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate metabotropic receptor 1

decreases expression

nonylphenol results in decreased expression of GRM1 mRNA

NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170

G

glutamate metabotropic receptor 2

decreases expression

nonylphenol results in decreased expression of GRM2 mRNA

NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146

G

glutamate metabotropic receptor 6

decreases expression

nonylphenol results in decreased expression of GRM6 mRNA

NCBI chr10:35,167,985...35,182,717
Ensembl chr10:35,167,985...35,182,717

G

gastrin releasing peptide receptor

decreases expression

nonylphenol results in decreased expression of GRPR mRNA

NCBI chr X:30,998,425...31,038,442
Ensembl chr X:30,998,416...31,038,442

G

gasdermin D

multiple interactions

nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of and results in increased cleavage of GSDMD mRNA]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of and results in increased cleavage of GSDMD protein]

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

glutathione S-transferase alpha 2

increases expression

nonylphenol results in increased expression of GSTA2 protein

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

histone deacetylase 2

multiple interactions
increases expression

AHR protein affects the reaction [nonylphenol results in increased expression of HDAC2 mRNA]; AHR protein affects the reaction [nonylphenol results in increased expression of HDAC2 protein]; HDAC2 protein affects the reaction [nonylphenol results in decreased expression of and results in decreased acetylation of HNF4A protein]; HDAC2 protein affects the reaction [nonylphenol results in decreased expression of TNFSF15 mRNA]; HDAC2 protein affects the reaction [nonylphenol results in increased expression of PECAM1 protein]
nonylphenol results in increased expression of HDAC2 mRNA; nonylphenol results in increased expression of HDAC2 protein

NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609

G

high mobility group box 1

increases expression

nonylphenol results in increased expression of HMGB1 protein

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

increases expression

nonylphenol results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

HNF1 homeobox A

decreases expression

nonylphenol results in decreased expression of HNF1A mRNA

NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104

G

hepatocyte nuclear factor 4, alpha

multiple interactions

AHR protein affects the reaction [nonylphenol results in decreased expression of and results in decreased acetylation of HNF4A protein]; HDAC2 protein affects the reaction [nonylphenol results in decreased expression of and results in decreased acetylation of HNF4A protein]; HNF4A protein inhibits the reaction [nonylphenol results in decreased expression of TNFSF15 mRNA]; HNF4A protein inhibits the reaction [nonylphenol results in increased expression of PECAM1 protein]; nonylphenol results in decreased expression of and results in decreased acetylation of HNF4A protein

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

hydroxysteroid 11-beta dehydrogenase 1

multiple interactions

nonylphenol results in increased expression of and results in increased activity of HSD11B1 protein

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression

nonylphenol results in decreased expression of HSD3B1 mRNA

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

heat shock protein family A (Hsp70) member 1A

increases expression

nonylphenol results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 5

affects expression
increases expression

nonylphenol affects the expression of HSPA5 protein
nonylphenol results in increased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 1

decreases expression

nonylphenol results in decreased expression of HSPB1 protein

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

5-hydroxytryptamine receptor 1F

decreases expression

nonylphenol results in decreased expression of HTR1F mRNA

NCBI chr11:2,642,751...2,644,150
Ensembl chr11:2,642,751...2,644,150

G

5-hydroxytryptamine receptor 6

multiple interactions

[nonylphenol co-treated with octylphenol] results in decreased expression of HTR6 protein; lycium barbarum polysaccharide inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased expression of HTR6 protein]

NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912

G

interferon beta 1

multiple interactions

nonylphenol inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

insulin-like growth factor binding protein 5

decreases expression

nonylphenol results in decreased expression of IGFBP5 mRNA

NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156

G

inhibitor of nuclear factor kappa B kinase subunit beta

increases expression
increases phosphorylation

nonylphenol results in increased expression of IKBKB mRNA
nonylphenol results in increased phosphorylation of IKBKB protein

PMID:17010207 PMID:35998786

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

multiple interactions
decreases expression

IL10 affects the reaction [nonylphenol results in increased expression of TNF]; nonylphenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL10]; nonylphenol results in decreased expression of and results in decreased secretion of IL10 protein
nonylphenol results in decreased expression of IL10

PMID:20056579 PMID:24039973

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12B

multiple interactions

nonylphenol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein]

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 18

increases expression
multiple interactions

nonylphenol results in increased expression of IL18 protein
nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of IL18 mRNA]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased secretion of IL18 protein]

PMID:35998786 PMID:38176579

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

multiple interactions

Fulvestrant inhibits the reaction [nonylphenol inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]]; nonylphenol inhibits the reaction [IL1A protein promotes the reaction [[RELA protein binds to NFKB1 protein] which binds to CCL2 promoter]]; nonylphenol inhibits the reaction [IL1A protein results in increased expression of CCL2 mRNA]; nonylphenol inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression
multiple interactions
increases secretion

nonylphenol results in increased expression of IL1B mRNA; nonylphenol results in increased expression of IL1B protein
nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of IL1B mRNA]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased secretion of IL1B protein]
nonylphenol results in increased secretion of IL1B protein

PMID:27260121 PMID:29484677 PMID:32240654 PMID:35998786 PMID:38176579

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

multiple interactions
increases expression

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [nonylphenol results in increased expression of IL4 protein]; Nitrendipine inhibits the reaction [nonylphenol results in increased expression of IL4 protein]; nonylphenol promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL4 protein]; nonylphenol promotes the reaction [NFATC3 protein binds to IL4 promoter]; Tacrolimus inhibits the reaction [nonylphenol promotes the reaction [NFATC3 protein binds to IL4 promoter]]; Tacrolimus inhibits the reaction [nonylphenol results in increased expression of IL4 protein]; Thapsigargin inhibits the reaction [nonylphenol results in increased expression of IL4 protein]
nonylphenol results in increased expression of IL4 mRNA; nonylphenol results in increased expression of IL4 protein

PMID:12709020 PMID:36029577

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

multiple interactions

nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL5 protein]

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

multiple interactions
increases secretion
increases expression

nonylphenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of IL6 mRNA]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased secretion of IL6 protein]
nonylphenol results in increased secretion of IL6 protein
nonylphenol results in increased expression of IL6 protein

PMID:28168795 PMID:29484677 PMID:32240654 PMID:38176579

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 7 receptor

multiple interactions

nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL7R mRNA]; nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL7R protein]

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

G

inhibin subunit alpha

increases expression

nonylphenol results in increased expression of INHA mRNA

NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248

G

inhibin subunit beta B

increases expression

nonylphenol analog results in increased expression of INHBB protein

NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832

G

insulin 1

increases expression
multiple interactions
increases secretion

nonylphenol results in increased expression of INS1 protein
Dactinomycin inhibits the reaction [nonylphenol results in increased secretion of INS1 protein]; Fulvestrant inhibits the reaction [nonylphenol results in increased secretion of INS1 protein]

PMID:15778011 PMID:21472897

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

Janus kinase 1

multiple interactions

nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of JAK1 protein]

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

multiple interactions

nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of JAK2 protein]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

nonylphenol results in decreased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kelch-like family member 41

increases expression

nonylphenol results in increased expression of KLHL41 mRNA

NCBI chr 3:54,434,291...54,447,415
Ensembl chr 3:54,434,234...54,449,222

G

lysine methyltransferase 2A

increases expression

nonylphenol results in increased expression of KMT2A protein

NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181

G

lipopolysaccharide binding protein

increases expression

nonylphenol results in increased expression of LBP mRNA

NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586

G

lymphocyte cytosolic protein 2

increases expression

nonylphenol results in increased expression of LCP2 mRNA

NCBI chr10:18,642,600...18,689,562
Ensembl chr10:18,642,658...18,689,559

G

lactate dehydrogenase A

increases expression

nonylphenol results in increased expression of LDHA mRNA

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

leptin

increases expression

nonylphenol results in increased expression of LEP mRNA

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

galectin 3

increases expression

nonylphenol results in increased expression of LGALS3 protein

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

G

lactotransferrin

increases expression

nonylphenol results in increased expression of LTF protein

NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795

G

monoamine oxidase A

multiple interactions

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased expression of MAOA protein]; [nonylphenol co-treated with octylphenol] results in decreased expression of MAOA protein; Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased expression of MAOA protein]; lycium barbarum polysaccharide inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased expression of MAOA protein]

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

microtubule-associated protein 1 light chain 3 alpha

increases expression

nonylphenol results in increased expression of MAP1LC3A mRNA

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

microtubule-associated protein 1 light chain 3 beta

increases cleavage
affects expression
multiple interactions

nonylphenol results in increased cleavage of MAP1LC3B protein
nonylphenol affects the expression of MAP1LC3B protein
Acetylcysteine inhibits the reaction [nonylphenol results in increased expression of MAP1LC3B protein]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen activated protein kinase kinase 3

increases expression

nonylphenol results in increased expression of MAP2K3 protein

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

mitogen-activated protein kinase kinase 6

increases expression

nonylphenol results in increased expression of MAP2K6 protein

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

mitogen activated protein kinase 1

increases phosphorylation
decreases phosphorylation

nonylphenol results in increased phosphorylation of MAPK1 protein
nonylphenol analog results in decreased phosphorylation of MAPK1 protein; nonylphenol results in decreased phosphorylation of MAPK1 protein

PMID:15531431 PMID:23677851 PMID:25242005 PMID:29484677

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen-activated protein kinase 11

multiple interactions

[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK11 protein; Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK11 protein]; lycium barbarum polysaccharide inhibits the reaction [[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK11 protein]

NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395

G

mitogen-activated protein kinase 12

multiple interactions

[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK12 protein; Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK12 protein]; lycium barbarum polysaccharide inhibits the reaction [[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK12 protein]

NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664

G

mitogen activated protein kinase 13

multiple interactions

[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK13 protein; Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK13 protein]; lycium barbarum polysaccharide inhibits the reaction [[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK13 protein]

NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222

G

mitogen activated protein kinase 14

multiple interactions

[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK14 protein; Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK14 protein]; lycium barbarum polysaccharide inhibits the reaction [[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

increases phosphorylation
decreases phosphorylation

nonylphenol results in increased phosphorylation of MAPK3 protein
nonylphenol analog results in decreased phosphorylation of MAPK3 protein; nonylphenol results in decreased phosphorylation of MAPK3 protein

PMID:15531431 PMID:23677851 PMID:25242005 PMID:29484677

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

minichromosome maintenance complex component 2

increases expression

nonylphenol results in increased expression of MCM2 mRNA; nonylphenol results in increased expression of MCM2 protein

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

G

minichromosome maintenance complex component 3

increases expression

nonylphenol results in increased expression of MCM3 mRNA; nonylphenol results in increased expression of MCM3 protein

NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314

G

minichromosome maintenance complex component 4

increases expression

nonylphenol results in increased expression of MCM4 mRNA; nonylphenol results in increased expression of MCM4 protein

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 5

increases expression

nonylphenol results in increased expression of MCM5 mRNA; nonylphenol results in increased expression of MCM5 protein

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

G

minichromosome maintenance complex component 6

increases expression

nonylphenol results in increased expression of MCM6 mRNA; nonylphenol results in increased expression of MCM6 protein

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

marker of proliferation Ki-67

increases expression
multiple interactions

nonylphenol results in increased expression of MKI67 mRNA
fulvestrant inhibits the reaction [nonylphenol results in increased expression of MKI67 mRNA]

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 2

multiple interactions
increases expression

fulvestrant inhibits the reaction [nonylphenol results in increased expression of MMP2 protein]; Genistein inhibits the reaction [nonylphenol results in increased expression of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions
increases expression

fulvestrant inhibits the reaction [nonylphenol results in increased expression of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mechanistic target of rapamycin kinase

decreases expression
increases expression
decreases phosphorylation

nonylphenol results in decreased expression of MTOR mRNA; nonylphenol results in decreased expression of MTOR protein; nonylphenol results in decreased expression of MTOR protein modified form
nonylphenol results in increased expression of MTOR protein modified form
nonylphenol results in decreased phosphorylation of MTOR protein

PMID:27832966 PMID:29641977

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYD88, innate immune signal transduction adaptor

increases expression

nonylphenol results in increased expression of MYD88 protein

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

Nanog homeobox

increases expression

nonylphenol results in increased expression of NANOG mRNA

NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116

G

nuclear receptor coactivator 1

multiple interactions

nonylphenol promotes the reaction [NCOA1 protein binds to CTSD promoter]

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

NADH:ubiquinone oxidoreductase subunit A1

decreases expression

nonylphenol results in decreased expression of NDUFA1 mRNA

NCBI chr X:116,424,223...116,427,875
Ensembl chr X:116,424,223...116,428,633

G

NADH:ubiquinone oxidoreductase subunit B6

decreases expression

nonylphenol results in decreased expression of NDUFB6 mRNA

NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181

G

nuclear factor of activated T-cells 3

multiple interactions

nonylphenol promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]; nonylphenol promotes the reaction [NFATC3 protein binds to IL4 promoter]; Tacrolimus inhibits the reaction [nonylphenol promotes the reaction [NFATC3 protein binds to IL4 promoter]]

NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150

G

NFE2 like bZIP transcription factor 2

increases expression

nonylphenol results in increased expression of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

nonylphenol inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]
nonylphenol inhibits the reaction [IL1A protein promotes the reaction [[RELA protein binds to NFKB1 protein] which binds to CCL2 promoter]]

PMID:10614622 PMID:17015962

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nerve growth factor

multiple interactions
increases expression

thymoquinone inhibits the reaction [nonylphenol results in increased expression of NGF protein]

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nitrilase 1

decreases expression

nonylphenol results in decreased expression of NIT1 protein

NCBI chr13:83,769,888...83,773,324
Ensembl chr13:83,765,941...83,773,332

G

NLR family, pyrin domain containing 3

increases expression
multiple interactions

nonylphenol results in increased expression of NLRP3 protein
nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of NLRP3 protein]; nonylphenol results in increased expression of [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of NLRP3 mRNA]
nonylphenol results in increased expression of NLRP3 mRNA; nonylphenol results in increased expression of NLRP3 protein

PMID:35998786 PMID:38176579

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

NME/NM23 nucleoside diphosphate kinase 2

increases expression

nonylphenol results in increased expression of NME2 protein

NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538

G

NME/NM23 family member 7

increases expression

nonylphenol results in increased expression of NME7 mRNA

NCBI chr13:76,657,303...76,786,768
Ensembl chr13:76,657,367...76,786,765

G

nitric oxide synthase 2

multiple interactions
increases expression

nonylphenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
nonylphenol results in increased expression of NOS2 protein

PMID:28168795 PMID:30481583

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 1, group I, member 2

affects response to substance
multiple interactions
increases response to substance

NR1I2 protein affects the susceptibility to nonylphenol
nonylphenol binds to and results in increased activity of NR1I2 protein
NR1I2 protein results in increased susceptibility to nonylphenol

PMID:14613717 PMID:16054614 PMID:21376070 PMID:33049310

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

nonylphenol affects the reaction [NR1I3 affects the susceptibility to Zoxazolamine]; nonylphenol binds to and results in increased activity of NR1I3 protein; nonylphenol inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; NR1I3 affects the reaction [nonylphenol results in decreased expression of CYP2C40 mRNA]; NR1I3 gene mutant form affects the reaction [nonylphenol results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form affects the reaction [nonylphenol results in increased expression of CYP2C29 mRNA]; NR1I3 gene mutant form affects the reaction [nonylphenol results in increased expression of CYP3A11 mRNA]

PMID:18832183 PMID:19041682

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

neurotrophic receptor tyrosine kinase 2

multiple interactions
decreases expression

[BDNF protein results in decreased susceptibility to nonylphenol] which results in increased expression of NTRK2 protein; BDNF protein inhibits the reaction [nonylphenol results in decreased expression of NTRK2 protein modified form]
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased phosphorylation of NTRK2 protein]; [nonylphenol co-treated with octylphenol] results in decreased phosphorylation of NTRK2 protein; Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased phosphorylation of NTRK2 protein]; lycium barbarum polysaccharide inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased phosphorylation of NTRK2 protein]
nonylphenol results in decreased expression of NTRK2 mRNA; nonylphenol results in decreased expression of NTRK2 protein; nonylphenol results in decreased expression of NTRK2 protein modified form

PMID:35662570 PMID:38642822

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

ornithine aminotransferase

decreases expression

nonylphenol results in decreased expression of OAT protein

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

G

oxoglutarate dehydrogenase

decreases expression

nonylphenol results in decreased expression of OGDH mRNA

NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479

G

opioid receptor, delta 1

decreases expression

nonylphenol results in decreased expression of OPRD1 mRNA

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid related nociceptin receptor 1

decreases expression

nonylphenol results in decreased expression of OPRL1 mRNA

NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920

G

opioid receptor, mu 1

increases expression

nonylphenol results in increased expression of OPRM1 mRNA

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

oxytocin/neurophysin I prepropeptide

increases expression

nonylphenol results in increased expression of OXT mRNA

NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490

G

purinergic receptor P2X 2

decreases expression

nonylphenol results in decreased expression of P2RX2 mRNA

NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891

G

purinergic receptor P2Y1

decreases expression

nonylphenol results in decreased expression of P2RY1 mRNA

NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

nonylphenol results in increased cleavage of PARP1 protein
U 0126 inhibits the reaction [nonylphenol results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

platelet derived growth factor receptor beta

decreases expression

nonylphenol results in decreased expression of PDGFRB mRNA

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

protein disulfide isomerase family A, member 3

affects expression
increases expression

nonylphenol affects the expression of PDIA3 protein
nonylphenol results in increased expression of PDIA3 protein

PMID:19260726 PMID:19429228

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236

G

pyruvate dehydrogenase kinase 1

decreases expression

nonylphenol results in decreased expression of PDK1 mRNA

NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038

G

pancreatic and duodenal homeobox 1

decreases expression

nonylphenol results in decreased expression of PDX1 mRNA

NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064

G

phosphatidylethanolamine binding protein 1

increases expression

nonylphenol results in increased expression of PEBP1 protein

NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862

G

platelet and endothelial cell adhesion molecule 1

increases expression
multiple interactions

nonylphenol results in increased expression of PECAM1 protein
AHR protein affects the reaction [nonylphenol results in increased expression of PECAM1 protein]; HDAC2 protein affects the reaction [nonylphenol results in increased expression of PECAM1 protein]; HNF4A protein inhibits the reaction [nonylphenol results in increased expression of PECAM1 protein]

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

increases expression

nonylphenol results in increased expression of PFKFB4 mRNA

NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634

G

progesterone receptor

affects binding
increases expression
decreases activity
multiple interactions

nonylphenol binds to PGR protein
nonylphenol analog results in increased expression of PGR mRNA
nonylphenol results in increased expression of PGR mRNA
nonylphenol results in increased expression of PGR mRNA; nonylphenol results in increased expression of PGR protein
nonylphenol results in decreased activity of PGR protein
nonylphenol inhibits the reaction [Progesterone binds to PGR protein]; nonylphenol inhibits the reaction [Progesterone results in increased expression of PGR protein]

PMID:14579009 PMID:14763995 PMID:17304841 PMID:18262749 PMID:20172022 More...

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

decreases expression
increases expression

nonylphenol results in decreased expression of PIK3CG mRNA
nonylphenol results in increased expression of PIK3CG mRNA

NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043

G

phosphoinositide-3-kinase regulatory subunit 1

decreases expression
multiple interactions

nonylphenol results in decreased expression of PIK3R1 protein
wortmannin inhibits the reaction [nonylphenol results in decreased expression of PIK3R1 protein]

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

phosphatidylinositol transfer protein, alpha

decreases expression

nonylphenol results in decreased expression of PITPNA protein

NCBI chr10:60,430,712...60,473,564
Ensembl chr10:60,430,748...60,471,342

G

proopiomelanocortin

multiple interactions
increases expression

Fulvestrant inhibits the reaction [nonylphenol promotes the reaction [POMC protein modified form results in increased secretion of Corticosterone]]; nonylphenol inhibits the reaction [Nitroprusside inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]]; nonylphenol promotes the reaction [POMC protein modified form results in increased secretion of Corticosterone]
nonylphenol results in increased expression of POMC protein

PMID:20837582 PMID:22765982

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

POU class 5 homeobox 1

increases expression

nonylphenol results in increased expression of POU5F1 mRNA

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator-activated receptor gamma

decreases expression
multiple interactions

nonylphenol results in decreased expression of PPARG protein
nonylphenol binds to and results in increased activity of PPARG protein

PMID:29641977 PMID:33049310

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 1 catalytic subunit beta

decreases expression

nonylphenol results in decreased expression of PPP1CB protein

NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824

G

PR/SET domain 14

increases expression

nonylphenol results in increased expression of PRDM14 mRNA

NCBI chr 5:6,082,163...6,092,712
Ensembl chr 5:6,082,442...6,092,712

G

peroxiredoxin 1

increases expression

nonylphenol results in increased expression of PRDX1 protein

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

peroxiredoxin 4

decreases expression

nonylphenol results in decreased expression of PRDX4 protein

NCBI chr X:40,026,762...40,044,066
Ensembl chr X:40,026,651...40,044,066

G

peroxiredoxin 6

increases expression
decreases expression

nonylphenol results in increased expression of PRDX6 protein
nonylphenol results in decreased expression of PRDX6 protein

NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355

G

protein kinase AMP-activated catalytic subunit alpha 1

decreases expression

nonylphenol results in decreased expression of PRKAA1 protein

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

prolactin

multiple interactions
increases secretion

Nifedipine inhibits the reaction [nonylphenol results in increased secretion of PRL protein]

PMID:15811834 PMID:19479013

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

prolactin releasing hormone receptor

increases expression

nonylphenol results in increased expression of PRLHR mRNA

NCBI chr 1:259,606,704...259,608,391
Ensembl chr 1:259,606,704...259,608,391

G

proteasome 20S subunit alpha 1

decreases expression

nonylphenol results in decreased expression of PSMA1 protein

NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472

G

proteasome 20S subunit alpha 2

increases expression

nonylphenol results in increased expression of PSMA2 protein

NCBI chr17:50,554,536...50,564,923
Ensembl chr17:50,551,924...50,564,938

G

proteasome 20S subunit beta 4

decreases expression

nonylphenol results in decreased expression of PSMB4 protein

NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746

G

proteasome 26S subunit, ATPase 2

decreases expression

nonylphenol results in decreased expression of PSMC2 protein

NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185

G

phosphatase and tensin homolog

increases expression
multiple interactions
decreases expression

nonylphenol results in increased expression of PTEN mRNA
wortmannin inhibits the reaction [nonylphenol results in decreased expression of PTEN protein]

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin D2 receptor

increases expression

nonylphenol results in increased expression of PTGDR mRNA

NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679

G

prostaglandin E receptor 2

decreases expression

nonylphenol results in decreased expression of PTGER2 mRNA

NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714

G

prostaglandin E receptor 4

decreases expression

nonylphenol results in decreased expression of PTGER4 mRNA

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

prostaglandin F receptor

decreases expression

nonylphenol results in decreased expression of PTGFR mRNA

NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [nonylphenol results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nonylphenol results in increased expression of PTGS2 protein]; [nonylphenol results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; nonylphenol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; nonylphenol results in increased expression of and results in increased activity of PTGS2 protein; SB 203580 inhibits the reaction [nonylphenol results in increased expression of PTGS2 protein]
nonylphenol results in increased expression of PTGS2 mRNA

PMID:20954072 PMID:28168795 PMID:30481583 PMID:30629985

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

PYD and CARD domain containing

multiple interactions

nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of PYCARD mRNA]

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

RAB14, member RAS oncogene family

increases expression

nonylphenol results in increased expression of RAB14 mRNA

NCBI chr 3:18,501,953...18,523,253
Ensembl chr 3:18,501,963...18,523,172

G

retinoic acid receptor, beta

decreases expression

nonylphenol results in decreased expression of RARB mRNA

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

RB transcriptional corepressor 1

increases phosphorylation

nonylphenol results in increased phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RNA binding fox-1 homolog 3

decreases expression
multiple interactions

nonylphenol results in decreased expression of RBFOX3 protein
thymoquinone inhibits the reaction [nonylphenol results in decreased expression of RBFOX3 protein]

NCBI chr10:103,720,355...104,157,277
Ensembl chr10:103,720,636...104,156,935

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases phosphorylation
increases expression

nonylphenol inhibits the reaction [IL1A protein promotes the reaction [[RELA protein binds to NFKB1 protein] which binds to CCL2 promoter]]
nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased phosphorylation of RELA protein]
nonylphenol results in increased phosphorylation of RELA protein
nonylphenol results in increased expression of RELA mRNA
nonylphenol results in increased phosphorylation of and affects the localization of RELA protein

PMID:10614622 PMID:30481583 PMID:35998786 PMID:38176579

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

resistin

increases expression

nonylphenol results in increased expression of RETN mRNA

NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620

G

Ras homolog, mTORC1 binding

increases expression

nonylphenol results in increased expression of RHEB mRNA

NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160

G

rabphilin 3A

increases expression

nonylphenol results in increased expression of RPH3A mRNA

NCBI chr12:35,542,389...35,618,901
Ensembl chr12:35,542,728...35,617,592

G

ribophorin II

increases expression

nonylphenol results in increased expression of RPN2 mRNA

NCBI chr 3:145,941,787...145,989,271
Ensembl chr 3:145,941,839...145,989,543

G

ribosomal protein S6 kinase B1

decreases expression
increases expression

nonylphenol results in decreased expression of RPS6KB1 mRNA
nonylphenol results in increased expression of RPS6KB1 mRNA

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

S100 calcium binding protein A6

increases expression

nonylphenol results in increased expression of S100A6 mRNA

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

S100 calcium binding protein G

multiple interactions
increases expression
decreases expression

fulvestrant inhibits the reaction [nonylphenol results in increased expression of S100G mRNA]; fulvestrant inhibits the reaction [nonylphenol results in increased expression of S100G protein]; Mifepristone inhibits the reaction [nonylphenol results in increased expression of S100G mRNA]; Mifepristone inhibits the reaction [nonylphenol results in increased expression of S100G protein]
nonylphenol results in increased expression of S100G mRNA; nonylphenol results in increased expression of S100G protein
nonylphenol results in decreased expression of S100G mRNA

PMID:12062901 PMID:12759100 PMID:14654251 PMID:15070829 PMID:15219628 More...

NCBI chr X:31,705,853...31,708,422
Ensembl chr X:31,705,866...31,708,433

G

secretin receptor

decreases expression

nonylphenol results in decreased expression of SCTR mRNA

NCBI chr13:31,127,781...31,190,162
Ensembl chr13:31,127,858...31,180,189

G

selenium binding protein 1

decreases expression

nonylphenol results in decreased expression of SELENBP1 mRNA

NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594

G

sex hormone binding globulin

multiple interactions
decreases expression
increases expression

nonylphenol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]
nonylphenol results in decreased expression of SHBG protein
nonylphenol results in increased expression of SHBG mRNA
wortmannin inhibits the reaction [nonylphenol results in increased expression of SHBG mRNA]

PMID:9171990 PMID:27832966

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

G

sirtuin 1

multiple interactions

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased expression of SIRT1 protein]; [nonylphenol co-treated with octylphenol] results in decreased expression of SIRT1 protein; Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased expression of SIRT1 protein]; lycium barbarum polysaccharide inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased expression of SIRT1 protein]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

SKI-like proto-oncogene

multiple interactions
increases expression

fulvestrant inhibits the reaction [nonylphenol results in increased expression of SKIL protein]; Genistein inhibits the reaction [nonylphenol results in increased expression of SKIL protein]

NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080

G

solute carrier family 12 member 2

decreases expression

nonylphenol results in decreased expression of SLC12A2 mRNA

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 1 member 5

increases expression

nonylphenol results in increased expression of SLC1A5 mRNA

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 22 member 6

increases expression

nonylphenol results in increased expression of SLC22A6 mRNA

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 2 member 2

decreases expression

nonylphenol results in decreased expression of SLC2A2 mRNA; nonylphenol results in decreased expression of SLC2A2 protein

PMID:21472897 PMID:22946080

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 6 member 3

multiple interactions

nonylphenol affects the reaction [SLC6A3 protein affects the export of Dopamine]

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

solute carrier family 7 member 11

increases expression

nonylphenol results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

schlafen family member 3

increases expression

nonylphenol results in increased expression of SLFN3 mRNA

NCBI chr10:68,020,482...68,060,248

G

SMAD family member 3

decreases phosphorylation
multiple interactions

nonylphenol results in decreased phosphorylation of SMAD3 protein
fulvestrant inhibits the reaction [nonylphenol results in decreased phosphorylation of SMAD3 protein]; Genistein inhibits the reaction [nonylphenol results in decreased phosphorylation of SMAD3 protein]

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

snail family transcriptional repressor 1

multiple interactions
increases expression

fulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI1 mRNA]; fulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI1 protein]
nonylphenol results in increased expression of SNAI1 mRNA; nonylphenol results in increased expression of SNAI1 protein

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

increases expression
multiple interactions

nonylphenol results in increased expression of SNAI2 mRNA
fulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI2 mRNA]

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

synaptosome associated protein 25

decreases expression

nonylphenol results in decreased expression of SNAP25 mRNA

NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760

G

superoxide dismutase 1

multiple interactions

[nonylphenol co-treated with octylphenol] results in decreased expression of SOD1 protein; lycium barbarum polysaccharide inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased expression of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

SRY-box transcription factor 2

increases expression

nonylphenol results in increased expression of SOX2 mRNA

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

steroidogenic acute regulatory protein

multiple interactions
decreases expression
increases expression

nonylphenol affects the reaction [CGA protein results in increased expression of STAR protein]
nonylphenol analog results in decreased expression of STAR mRNA
nonylphenol results in increased expression of STAR protein

PMID:19883722 PMID:22765982 PMID:22771390

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

signal transducer and activator of transcription 3

multiple interactions

nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

serine/threonine kinase 17b

increases expression

nonylphenol results in increased expression of STK17B mRNA

NCBI chr 9:55,307,485...55,338,085
Ensembl chr 9:55,307,668...55,338,031

G

stimulated by retinoic acid 8

increases expression

nonylphenol results in increased expression of STRA8 mRNA

NCBI chr 4:63,601,443...63,624,777
Ensembl chr 4:63,601,604...63,624,771

G

tachykinin receptor 2

decreases expression

nonylphenol results in decreased expression of TACR2 mRNA

NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,208,907...30,223,446

G

TAR DNA binding protein

decreases expression

nonylphenol results in decreased expression of TARDBP protein

NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055

G

t-complex 1

increases expression

nonylphenol results in increased expression of TCP1 protein

NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839

G

transferrin

affects expression
decreases expression

nonylphenol affects the expression of TF mRNA
nonylphenol results in decreased expression of TF protein

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

trefoil factor 1

multiple interactions
decreases expression
increases expression

[nonylphenol results in increased activity of ESR1 protein] which results in increased expression of TFF1 mRNA
nonylphenol results in decreased expression of TFF1 protein
nonylphenol results in increased expression of TFF1 mRNA

PMID:14709801 PMID:14754635 PMID:35998786

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

transforming growth factor, beta 3

multiple interactions

TGFB3 protein inhibits the reaction [nonylphenol results in increased expression of ESR1 mRNA]; TGFB3 protein inhibits the reaction [nonylphenol results in increased expression of FOS mRNA]

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

thyroid hormone receptor alpha

increases expression

nonylphenol results in increased expression of THRA protein

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

thyroid hormone receptor beta

increases expression

nonylphenol results in increased expression of THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

tight junction protein 1

decreases expression

nonylphenol results in decreased expression of TJP1 protein

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

toll-like receptor 4

decreases expression
increases expression

nonylphenol analog results in decreased expression of TLR4 mRNA
nonylphenol results in increased expression of TLR4 protein

PMID:25242005 PMID:30481583

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
increases expression
increases secretion

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [nonylphenol results in increased expression of and results in increased secretion of TNF protein]; anacardic acid inhibits the reaction [nonylphenol results in increased expression of and results in increased secretion of TNF protein]; anacardic acid inhibits the reaction [nonylphenol results in increased expression of TNF]; Fulvestrant inhibits the reaction [nonylphenol results in increased expression of and results in increased secretion of TNF protein]; Fulvestrant inhibits the reaction [nonylphenol results in increased expression of TNF]; IL10 affects the reaction [nonylphenol results in increased expression of TNF]; nonylphenol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; nonylphenol results in increased expression of and results in increased secretion of TNF protein; SB 203580 inhibits the reaction [nonylphenol results in increased expression of and results in increased secretion of TNF protein]; SB 203580 inhibits the reaction [nonylphenol results in increased expression of TNF]
nonylphenol results in increased expression of TNF protein
nonylphenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased expression of TNF mRNA]; nonylphenol promotes the reaction [[OVAL protein co-treated with Aluminum Hydroxide] results in increased secretion of TNF protein]
nonylphenol results in increased secretion of TNF protein
nonylphenol results in increased expression of TNF; nonylphenol results in increased expression of TNF mRNA; nonylphenol results in increased expression of TNF protein

PMID:20056579 PMID:24039973 PMID:28168795 PMID:32240654 PMID:35998786 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 4

multiple interactions

nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNFRSF4 mRNA]

NCBI chr 5:166,606,909...166,609,599
Ensembl chr 5:166,606,909...166,609,599

G

TNF superfamily member 15

multiple interactions
decreases expression

AHR protein affects the reaction [nonylphenol results in decreased expression of and results in decreased secretion of TNFSF15 protein]; AHR protein affects the reaction [nonylphenol results in decreased expression of TNFSF15 mRNA]; HDAC2 protein affects the reaction [nonylphenol results in decreased expression of TNFSF15 mRNA]; HNF4A protein inhibits the reaction [nonylphenol results in decreased expression of TNFSF15 mRNA]; nonylphenol results in decreased expression of and results in decreased secretion of TNFSF15 protein

NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228

G

TNF superfamily member 4

multiple interactions

nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNFSF4 mRNA]

NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788

G

torsin family 1, member A

decreases expression

nonylphenol results in decreased expression of TOR1A protein

NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691

G

TNF receptor associated factor 6

increases expression

nonylphenol results in increased expression of TRAF6 protein

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

G

TSC complex subunit 1

decreases expression

nonylphenol results in decreased expression of TSC1 protein

NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674

G

TSC complex subunit 2

affects expression
decreases expression

nonylphenol affects the expression of TSC2 mRNA
nonylphenol results in decreased expression of TSC2 protein

PMID:27832966 PMID:29641977

NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951

G

thyroid stimulating hormone receptor

decreases expression

nonylphenol results in decreased expression of TSHR mRNA

NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538

G

thymic stromal lymphopoietin

multiple interactions

nonylphenol promotes the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TSLP protein]

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

G

transthyretin

affects binding

nonylphenol binds to TTR protein

NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008

G

tubulin, beta 6 class V

decreases expression

nonylphenol results in decreased expression of TUBB6 protein

NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418

G

Tu translation elongation factor, mitochondrial

increases expression

nonylphenol results in increased expression of TUFM protein

NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395

G

uncoupling protein 2

increases expression
decreases expression

nonylphenol results in increased expression of UCP2 mRNA
nonylphenol results in decreased expression of UCP2 mRNA

PMID:22946080 PMID:32645552

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases glucuronidation

UGT2B1 protein results in increased glucuronidation of nonylphenol

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

vinculin

decreases expression

nonylphenol analog results in decreased expression of VCL mRNA

NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606

G

vascular endothelial growth factor A

decreases expression

nonylphenol results in decreased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

increases expression
decreases expression
multiple interactions

nonylphenol analog results in increased expression of VIM mRNA
nonylphenol results in decreased expression of VIM protein
nonylphenol results in increased expression of VIM mRNA; nonylphenol results in increased expression of VIM protein
fulvestrant inhibits the reaction [nonylphenol results in increased expression of VIM mRNA]; fulvestrant inhibits the reaction [nonylphenol results in increased expression of VIM protein]

PMID:25242005 PMID:25690688 PMID:26407941 PMID:27832966

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

tryptophanyl-tRNA synthetase 1

increases expression

nonylphenol results in increased expression of WARS1 mRNA

NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269

G

WD repeat domain 1

increases expression

nonylphenol results in increased expression of WDR1 protein

NCBI chr14:72,258,032...72,291,768
Ensembl chr14:72,257,956...72,291,766

G

WD repeat domain 5

increases expression

nonylphenol results in increased expression of WDR5 protein

NCBI chr 3:10,836,964...10,856,682
Ensembl chr 3:10,837,025...10,856,671

G

zinc finger protein 42

increases expression

nonylphenol results in increased expression of ZFP42 mRNA

NCBI chr16:48,836,463...48,845,443
Ensembl chr16:48,836,648...48,845,401

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19911
chemical entity	19909
atom	19909
nonmetal atom	19832
carbon atom	19785
organic molecular entity	19785
Nonylphenol	297
Path 2
Term	Annotations
CHEBI ontology	19911
subatomic particle	19909
composite particle	19909
hadron	19880
baryon	19880
nucleon	19909
atomic nucleus	19880
atom	19909
main group element atom	19849
p-block element atom	19849
carbon group element atom	19766
carbon atom	19785
organic molecular entity	19785
Nonylphenol	297

paths to the root