Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:elesclomol
go back to main search page
Accession:CHEBI:79369 term browser browse the term
Definition:A carbohydrazide obtained by formal condensation of the carboxy groups of malonic acid with the hydrino groups of two molar equivalents of N-methylbenzenecarbothiohydrazide
Synonyms:exact_synonym: N'(1),N'(3)-dimethyl-N'(1),N'(3)-bis(phenylcarbonothioyl)malonohydrazide
 related_synonym: 1-N'-Benzenecarbothioyl-3-(2-benzenecarbothioyl-2-methylhydrazinyl)-N'-methyl-oxopropanehydrazidide;   Formula=C19H20N4O2S2;   InChI=1S/C19H20N4O2S2/c1-22(18(26)14-9-5-3-6-10-14)20-16(24)13-17(25)21-23(2)19(27)15-11-7-4-8-12-15/h3-12H,13H2,1-2H3,(H,20,24)(H,21,25);   InChIKey=BKJIXTWSNXCKJH-UHFFFAOYSA-N;   SMILES=CN(NC(=O)CC(=O)NN(C)C(=S)c1ccccc1)C(=S)c1ccccc1;   elesclomolum
 alt_id: MESH:C512195
 xref: CAS:488832-69-5;   KEGG:D08909;   LINCS:LSM-4929
 xref_mesh: MESH:C512195
 xref: PMID:18389103;   PMID:18723479;   PMID:19609669;   PMID:19826135;   PMID:20933353;   PMID:22253786;   PMID:22425348;   PMID:22542443;   PMID:22865452;   PMID:23401447;   PMID:23707906;   PMID:23937981;   PMID:24161908;   PMID:24176921;   PMID:24798374;   Patent:WO2011133673;   Reaxys:11332608;   Wikipedia:Elesclomol

show annotations for term's descendants           Sort by:
 
elesclomol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag3 BAG cochaperone 3 increases expression
multiple interactions		 ISO elesclomol results in increased expression of BAG3 mRNA
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of BAG3 mRNA]		 CTD PMID:18723479 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191 		JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression ISO elesclomol results in increased expression of CHORDC1 mRNA CTD PMID:18723479 NCBI chr 8:17,421,552...17,445,513
Ensembl chr 8:17,421,557...17,446,165 		JBrowse link
G Clk1 CDC-like kinase 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of CLK1 mRNA] CTD PMID:18723479 NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO elesclomol results in increased expression of CRYAB mRNA CTD PMID:18723479 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of DNAJB1 mRNA] CTD PMID:18723479 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of DNAJB4 mRNA] CTD PMID:18723479 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO elesclomol results in increased expression of DNAJB9 mRNA CTD PMID:18723479 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO elesclomol results in increased expression of FTL mRNA CTD PMID:18723479 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of GCLM mRNA] CTD PMID:18723479 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Gla galactosidase, alpha increases expression ISO elesclomol results in increased expression of GLA mRNA CTD PMID:18723479 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression
multiple interactions		 ISO elesclomol results in increased expression of HERPUD1 mRNA
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HERPUD1 mRNA]		 CTD PMID:18723479 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HMOX1 mRNA] CTD PMID:18723479 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HSPA1A mRNA] CTD PMID:18723479 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HSPA1B mRNA] CTD PMID:18723479 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO elesclomol results in increased expression of HSPH1 mRNA CTD PMID:18723479 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902 		JBrowse link
G Ier5 immediate early response 5 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of IER5 mRNA] CTD PMID:18723479 NCBI chr13:72,742,210...72,744,302
Ensembl chr13:72,742,210...72,744,303 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of IFRD1 mRNA] CTD PMID:18723479 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420 		JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO elesclomol results in increased expression of HSPA6 mRNA CTD PMID:18723479 NCBI chr13:89,408,703...89,411,500 JBrowse link
G Oser1 oxidative stress responsive serine-rich 1 increases expression
multiple interactions		 ISO elesclomol results in increased expression of OSER1 mRNA
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of OSER1 mRNA]		 CTD PMID:18723479 NCBI chr 3:159,784,131...159,802,923
Ensembl chr 3:159,784,128...159,802,952 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of PMAIP1 mRNA] CTD PMID:18723479 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO elesclomol results in increased expression of PPP1R15A mRNA CTD PMID:18723479 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974 		JBrowse link
G Psmc1 proteasome 26S subunit, ATPase 1 increases expression ISO elesclomol results in increased expression of PSMC1 mRNA CTD PMID:18723479 NCBI chr 6:124,123,283...124,135,644
Ensembl chr 6:124,123,228...124,135,658 		JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 increases expression ISO elesclomol results in increased expression of PSMC4 mRNA CTD PMID:18723479 NCBI chr 1:84,978,220...84,986,536
Ensembl chr 1:84,978,206...84,986,581 		JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 increases expression ISO elesclomol results in increased expression of PSMC6 mRNA CTD PMID:18723479 NCBI chr15:19,667,453...19,688,916
Ensembl chr15:19,667,453...19,688,914 		JBrowse link
G Psmd1 proteasome 26S subunit, non-ATPase 1 increases expression ISO elesclomol results in increased expression of PSMD1 mRNA CTD PMID:18723479 NCBI chr 9:93,080,618...93,155,033
Ensembl chr 9:93,080,615...93,155,027 		JBrowse link
G Psmd12 proteasome 26S subunit, non-ATPase 12 increases expression ISO elesclomol results in increased expression of PSMD12 mRNA CTD PMID:18723479 NCBI chr10:95,706,808...95,725,452
Ensembl chr10:95,706,685...95,725,812 		JBrowse link
G Psmd2 proteasome 26S subunit, non-ATPase 2 increases expression ISO elesclomol results in increased expression of PSMD2 mRNA CTD PMID:18723479 NCBI chr11:83,934,098...83,944,725
Ensembl chr11:83,934,087...83,944,763 		JBrowse link
G Psme4 proteasome activator subunit 4 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of PSME4 mRNA] CTD PMID:18723479 NCBI chr14:115,166,165...115,269,041
Ensembl chr14:115,166,416...115,269,056 		JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 increases expression ISO elesclomol results in increased expression of RB1CC1 mRNA CTD PMID:18723479 NCBI chr 5:13,033,918...13,097,369
Ensembl chr 5:13,033,918...13,097,341 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SAT1 mRNA] CTD PMID:18723479 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765 		JBrowse link
G Sde2 SDE2 telomere maintenance homolog increases expression ISO elesclomol results in increased expression of SDE2 mRNA CTD PMID:18723479 NCBI chr13:99,136,921...99,153,187
Ensembl chr13:99,136,871...99,153,181 		JBrowse link
G Slc19a2 solute carrier family 19 member 2 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SLC19A2 mRNA] CTD PMID:18723479 NCBI chr13:82,552,586...82,566,586
Ensembl chr13:82,552,550...82,566,586 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SLC30A1 mRNA] CTD PMID:18723479 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SLC7A11 mRNA] CTD PMID:18723479 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of TRIB3 mRNA] CTD PMID:18723479 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO elesclomol results in increased expression of TXNRD1 mRNA CTD PMID:18723479 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400 		JBrowse link
G Ufm1 ubiquitin-fold modifier 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of UFM1 mRNA] CTD PMID:18723479 NCBI chr 2:143,096,268...143,104,412
Ensembl chr 2:143,096,271...143,104,412 		JBrowse link
G Uspl1 ubiquitin specific peptidase like 1 increases expression
multiple interactions		 ISO elesclomol results in increased expression of USPL1 mRNA
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of USPL1 mRNA]		 CTD PMID:18723479 NCBI chr12:6,930,018...6,957,027
Ensembl chr12:6,929,978...6,956,984 		JBrowse link
G Yrdc yrdC N(6)-threonylcarbamoyltransferase domain containing increases expression ISO elesclomol results in increased expression of YRDC mRNA CTD PMID:18723479 NCBI chr 5:142,845,265...142,850,110
Ensembl chr 5:142,845,114...142,850,111 		JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 increases expression ISO elesclomol results in increased expression of ZC3HAV1 mRNA CTD PMID:18723479 NCBI chr 4:66,012,111...66,062,160
Ensembl chr 4:66,011,915...66,062,089 		JBrowse link
G Zfand2a zinc finger AN1-type containing 2A multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of ZFAND2A mRNA] CTD PMID:18723479 NCBI chr12:17,252,093...17,263,477
Ensembl chr12:17,252,093...17,263,477 		JBrowse link
G Zfp394 zinc finger protein 394 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of ZNF394 mRNA] CTD PMID:18723479 NCBI chr12:11,179,323...11,187,362
Ensembl chr12:11,179,329...11,187,380 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        biochemical role 19328
          apoptosis inducer 10989
            elesclomol 42
              elesclomol-Cu(II) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      dicarboxylic acids and O-substituted derivatives 10290
                                        dicarboxylic acid 10282
                                          alpha,omega-dicarboxylic acid 2781
                                            malonic acid 60
                                              elesclomol 42
                                                elesclomol-Cu(II) 0
paths to the root