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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:paroxetine
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Accession:CHEBI:7936 term browser browse the term
Definition:A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.
Synonyms:exact_synonym: (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
 related_synonym: (-)-(3S,4R)-4-(p-fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine;   (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine;   Formula=C19H20FNO3;   InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1;   InChIKey=AHOUBRCZNHFOSL-YOEHRIQHSA-N;   SMILES=[H][C@]1(CCNC[C@H]1COc1ccc2OCOc2c1)c1ccc(F)cc1;   paroxetina;   paroxetinum
 xref: Beilstein:7467879;   CAS:61869-08-7;   DrugBank:DB00715;   Drug_Central:2068;   KEGG:C07415;   KEGG:D02362;   LINCS:LSM-2843
 xref_mesh: MESH:D017374
 xref: PMID:11009210;   PMID:11169163;   PMID:11271409;   PMID:11281965;   PMID:11324355;   PMID:11360029;   PMID:11513198;   PMID:11563413;   PMID:11565622;   PMID:11819027;   PMID:11893234;   PMID:11910269;   PMID:12027788;   PMID:12088162;   PMID:12369443;   PMID:12421645;   PMID:12818234;   PMID:12820211;   PMID:12906023;   PMID:12920419;   PMID:14516531;   PMID:14521492;   PMID:14566196;   PMID:14566200;   PMID:14619895;   PMID:14624192;   PMID:14673053;   PMID:14689334;   PMID:14978354;   PMID:15048901;   PMID:15199661;   PMID:15241233;   PMID:15264994;   PMID:15374134;   PMID:15376524;   PMID:15544025;   PMID:15613191;   PMID:15845695;   PMID:15853570;   PMID:15903129;   PMID:15963219;   PMID:15992089;   PMID:16395417;   PMID:16397315;   PMID:16426087;   PMID:16765127;   PMID:16822276;   PMID:16913391;   PMID:17122538;   PMID:17162096;   PMID:17219219;   PMID:17286545;   PMID:17452166;   PMID:17559097;   PMID:17612590;   PMID:17652957;   PMID:17874333;   PMID:18273418;   PMID:18345955;   PMID:18808757;   PMID:18983224;   PMID:19687003;   PMID:19851065;   PMID:21404089;   PMID:21452176;   PMID:21739267;   PMID:21908494;   PMID:21909633;   PMID:21922171;   PMID:21939725;   PMID:22153922;   PMID:22198456;   PMID:22212003;   PMID:22240860;   PMID:22263916;   PMID:22283559;   PMID:22353759;   PMID:22377745;   Reaxys:7467879;   Wikipedia:Paroxetine
 cyclic_relationship: is_conjugate_base_of CHEBI:64197


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paroxetine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of Paroxetine CTD PMID:14550684 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Paroxetine results in increased expression of ABCC2 protein CTD PMID:12524417 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Paroxetine binds to APP 5' UTR] which results in decreased secretion of APP protein modified form CTD PMID:15681799 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor multiple interactions ISO Paroxetine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP Paroxetine results in increased expression of ARC mRNA CTD PMID:14580947 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO Paroxetine results in increased expression of BDNF mRNA; Paroxetine results in increased expression of BDNF protein CTD PMID:21301813 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Paroxetine results in increased activity of and results in increased cleavage of CASP3 protein
Paroxetine results in increased activity of CASP3 protein
CTD PMID:17174998 PMID:28482088 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO Paroxetine results in increased activity of CASP8 protein CTD PMID:28482088 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO Paroxetine results in increased activity of CASP9 protein CTD PMID:28482088 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Chl1 cell adhesion molecule L1-like affects response to substance ISO CHL1 affects the susceptibility to Paroxetine CTD PMID:21332311 NCBI chr 4:70,269,414...70,331,313
Ensembl chr 4:70,252,366...70,330,803
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Paroxetine results in decreased activity of CYP19A1 protein CTD PMID:26162595 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity
ISO Paroxetine inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of hydroxybupropion]; Paroxetine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]
Paroxetine results in decreased activity of CYP2B6 protein
CTD PMID:21915887 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases metabolic processing
decreases activity
multiple interactions
increases metabolic processing
increases response to substance
ISO CYP2D6 gene mutant form results in decreased metabolism of Paroxetine
Paroxetine results in decreased activity of CYP2D6 protein
[Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased abundance of 4-hydroxy-N-desmethyltamoxifen; [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased degradation of Metoprolol; [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [Paroxetine results in decreased activity of CYP2D6 protein] which results in increased susceptibility to Metoprolol; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin]; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline]; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in increased abundance of 10-hydroxynortriptyline]; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite]; Paroxetine inhibits the reaction [CYP2D6 protein results in increased chemical synthesis of Dextrorphan]; Paroxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Paroxetine inhibits the reaction [CYP2D6 protein results in increased oxidation of dimemorfan]
CYP2D6 protein results in increased metabolism of Paroxetine
CYP2D6 gene mutant form results in increased susceptibility to Paroxetine
CTD PMID:10470702 PMID:11673748 PMID:12173784 PMID:12378847 PMID:14639062 PMID:14652237 PMID:15570195 PMID:15632378 PMID:15860655 PMID:19593786 PMID:21915887 PMID:26599973 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH protein results in increased susceptibility to Paroxetine CTD PMID:15148402 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 multiple interactions ISO Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of DDAH1 protein] CTD PMID:21312047 NCBI chr 2:251,634,368...251,766,009
Ensembl chr 2:251,634,431...251,766,014
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein CTD PMID:19662385 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of GLUD1 protein] CTD PMID:21312047 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Hcrtr1 hypocretin receptor 1 increases expression ISO Paroxetine results in increased expression of HCRTR1 mRNA CTD PMID:21157932 NCBI chr 5:148,346,029...148,355,404
Ensembl chr 5:148,346,031...148,355,406
JBrowse link
G Hcrtr2 hypocretin receptor 2 increases expression ISO Paroxetine results in increased expression of HCRTR2 mRNA CTD PMID:21157932 NCBI chr 8:83,307,684...83,421,612
Ensembl chr 8:83,307,684...83,421,612
JBrowse link
G Hrh1 histamine receptor H 1 increases expression ISO Paroxetine results in increased expression of HRH1 mRNA CTD PMID:21157932 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B decreases expression EXP Paroxetine results in decreased expression of HTR1B mRNA CTD PMID:10861803 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects response to substance ISO HTR2A gene polymorphism affects the susceptibility to Paroxetine CTD PMID:17503984 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions ISO [[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; Paroxetine binds to and results in increased activity of HTR2C protein CTD PMID:19662385 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
ISO Paroxetine results in increased expression of IL10 mRNA; Paroxetine results in increased expression of IL10 protein
LY 215840 inhibits the reaction [Paroxetine results in increased expression of IL10 mRNA]; LY 215840 inhibits the reaction [Paroxetine results in increased expression of IL10 protein]
CTD PMID:32020710 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il17a interleukin 17A multiple interactions
decreases expression
ISO LY 215840 inhibits the reaction [Paroxetine results in decreased expression of IL17A protein] CTD PMID:32020710 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta affects expression ISO Paroxetine affects the expression of IL1B protein CTD PMID:32020710 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Ins2 insulin 2 multiple interactions EXP Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]; pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]] CTD PMID:17728140 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
decreases activity
EXP Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]; pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]]
Paroxetine results in decreased activity of IRS1 protein
CTD PMID:17728140 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Jak2 Janus kinase 2 multiple interactions
increases expression
ISO LY 215840 promotes the reaction [Paroxetine results in increased expression of JAK2 mRNA] CTD PMID:32020710 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Paroxetine results in decreased activity of [KCNJ3 protein binds to KCNJ6 protein] CTD PMID:17072103 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Paroxetine results in decreased activity of [KCNJ6 protein binds to KCNJ5 protein] CTD PMID:17072103 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Paroxetine results in decreased activity of [KCNJ3 protein binds to KCNJ6 protein]; Paroxetine results in decreased activity of [KCNJ6 protein binds to KCNJ5 protein]; Paroxetine results in decreased activity of [KCNJ6 protein binds to KCNJ6 protein] CTD PMID:17072103 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:19662385 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:19662385 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity
multiple interactions
EXP Paroxetine results in increased activity of MAPK8 protein
pyrazolanthrone inhibits the reaction [Paroxetine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
CTD PMID:17728140 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Pf4 platelet factor 4 decreases expression ISO Paroxetine results in decreased expression of PF4 protein CTD PMID:10770450 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Ppbp pro-platelet basic protein decreases expression ISO Paroxetine results in decreased expression of PPBP protein CTD PMID:10770450 NCBI chr14:18,852,433...18,853,237
Ensembl chr14:18,851,954...18,853,315
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Paroxetine results in decreased expression of PTGS2 mRNA; Paroxetine results in decreased expression of PTGS2 protein CTD PMID:17499975 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Paroxetine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions ISO Paroxetine inhibits the reaction [Corticosterone results in decreased expression of SLC6A15 mRNA] CTD PMID:31344373 NCBI chr 7:45,328,207...45,381,920
Ensembl chr 7:45,328,105...45,382,229
JBrowse link
G Slc6a4 solute carrier family 6 member 4 decreases expression
multiple interactions
affects expression
ISO
EXP
Paroxetine results in decreased expression of SLC6A4 mRNA
Paroxetine binds to and results in decreased activity of SLC6A4 protein
Paroxetine affects the expression of SLC6A4 mRNA
CTD PMID:10575045 PMID:16055263 PMID:16272152 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Paroxetine inhibits the reaction [Manganese deficiency results in increased expression of SOD2 protein] CTD PMID:21312047 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression
increases expression
multiple interactions
ISO Paroxetine results in decreased expression of STAT3 mRNA; Paroxetine results in decreased expression of STAT3 protein
Paroxetine results in increased expression of STAT3 mRNA
LY 215840 promotes the reaction [Paroxetine results in increased expression of STAT3 mRNA]
CTD PMID:17499975 PMID:32020710 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tfap2a transcription factor AP-2 alpha increases expression ISO Paroxetine results in increased expression of TFAP2A protein CTD PMID:28844482 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions
decreases expression
ISO Paroxetine results in decreased secretion of TNF protein
LY 215840 inhibits the reaction [Paroxetine results in decreased expression of TNF protein]
CTD PMID:17499975 PMID:32020710 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Paroxetine results in increased expression of VEGFA mRNA CTD PMID:21301813 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vgf VGF nerve growth factor inducible increases expression ISO Paroxetine results in increased expression of VGF mRNA CTD PMID:21301813 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630
JBrowse link

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  CHEBI ontology 19771
    role 19716
      biological role 19716
        aetiopathogenetic role 18967
          hepatotoxic agent 14575
            paroxetine 47
              N-methylparoxetine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic molecule 19497
                              organic cyclic compound 19321
                                carbocyclic compound 18297
                                  benzenoid aromatic compound 17402
                                    benzenes 17174
                                      fluorobenzenes 1658
                                        monofluorobenzenes 1326
                                          monofluorobenzene 90
                                            paroxetine 47
                                              N-methylparoxetine 0
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