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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:paromomycin
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Accession:CHEBI:7934 term browser browse the term
Definition:An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.
Synonyms:related_synonym: (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside;   Aminosidin;   Catenulin;   Formula=C23H45N5O14;   Hydroxymycin;   InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1;   InChIKey=UOZODPSAJZTQNH-LSWIJEOBSA-N;   Monomycin A;   Paromomycin I;   R-400;   SMILES=NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O;   Zygomycin A1;   aminosidine;   crestomycin;   estomycin;   neomycin E;   paromomicina;   paromomycine;   paromomycinum;   paucimycin;   paucimycinum
 alt_id: CHEBI:44703
 xref: CAS:7542-37-2;   DrugBank:DB01421;   Drug_Central:2067;   KEGG:C00832;   KEGG:D07467
 xref_mesh: MESH:D010303
 xref: PDBeChem:PAR;   PMID:18447603;   PMID:18947845;   PMID:8036682;   Patent:US2895876;   Patent:US2916485;   Reaxys:72285



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paromomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase increases expression ISO Paromomycin results in increased expression of ATM protein mutant form CTD PMID:15498871 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        antimicrobial agent 17758
          carbohydrate-containing antibiotic 7524
            aminoglycoside antibiotic 7512
              paromomycin 1
                lividomycin A 0
                lividomycin B + 0
                paromomycin sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            heteroorganic entity 19555
                              organochalcogen compound 19293
                                organooxygen compound 19239
                                  carbohydrates and carbohydrate derivatives 13914
                                    carbohydrate 13914
                                      carbohydrate derivative 13640
                                        glycosyl compound 12896
                                          glycoside 11734
                                            aminoglycoside 11161
                                              aminoglycoside antibiotic 7512
                                                paromomycin 1
                                                  lividomycin A 0
                                                  lividomycin B + 0
                                                  paromomycin sulfate 0
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