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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glucosinolic acid
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Accession:CHEBI:79316 term browser browse the term
Definition:A glycosinolic acid derived from glucose. Glucosinolic acids have a central C atom which is bonded via an S atom to a glucosyl group and via an N atom to a sulfonated oxime group, and which also carries a side-group. The side-chain and sulfate group have an anti stereochemical configuration across the C=N double bond.
Synonyms:related_synonym: Formula=C7H12NO9S2R;   SMILES=[C@H]1(O[C@@H]([C@@H](O)[C@@H]([C@H]1O)O)CO)S/C(=N\\OS(O)(=O)=O)/*;   glucosinolic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:24279


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glucobrassicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpx2 glutathione peroxidase 2 multiple interactions
decreases expression		 ISO glucobrassicin analog inhibits the reaction [glucoraphanin analog results in increased expression of GPX2 mRNA]
glucobrassicin analog results in decreased expression of GPX2 protein		 CTD PMID:20868228 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
decreases activity		 ISO glucobrassicin analog inhibits the reaction [glucoraphanin results in increased activity of NQO1 protein]
glucobrassicin analog results in decreased activity of NQO1 protein		 CTD PMID:20868228 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
glucoerucin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP glucoerucin results in increased expression of CYP1A1 protein CTD PMID:20833222 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP glucoerucin results in increased expression of CYP1A2 protein CTD PMID:20833222 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP glucoerucin results in increased expression of CYP1B1 protein CTD PMID:20833222 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP glucoerucin results in increased expression of EPHX1 protein CTD PMID:21132492 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP glucoerucin results in increased activity of NQO1 protein CTD PMID:20833222 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
glucoraphanin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP glucoraphanin results in increased expression of CYP1A1 protein CTD PMID:20833222 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP glucoraphanin results in increased expression of CYP1A2 protein CTD PMID:20833222 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP glucoraphanin results in increased expression of CYP1B1 protein CTD PMID:20833222 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP glucoraphanin results in increased expression of EPHX1 protein CTD PMID:21132492 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression
multiple interactions		 ISO glucoraphanin analog results in increased expression of GPX2 mRNA; glucoraphanin analog results in increased expression of GPX2 protein
Benzo(a)pyrene inhibits the reaction [glucoraphanin results in increased expression of GPX2 mRNA]; glucobrassicin analog inhibits the reaction [glucoraphanin analog results in increased expression of GPX2 mRNA]		 CTD PMID:20868228 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization ISO glucoraphanin analog affects the localization of NFE2L2 protein CTD PMID:20868228 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases activity		 ISO
EXP		 glucobrassicin analog inhibits the reaction [glucoraphanin results in increased activity of NQO1 protein]
glucoraphanin analog results in increased activity of NQO1 protein		 CTD PMID:20833222 PMID:20868228 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
neoglucobrassicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis ISO 1-methoxy-3-indolylmethylglucosinolate metabolite results in increased mutagenesis of HPRT1 gene CTD PMID:20846518 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases response to substance ISO SULT1A1 protein results in increased susceptibility to 1-methoxy-3-indolylmethylglucosinolate metabolite CTD PMID:20846518 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
sinigrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr7a3 aldo-keto reductase family 7 member A3 increases activity EXP sinigrin results in increased activity of AKR7A3 protein CTD PMID:9328168 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases activity EXP sinigrin results in increased activity of GSTA5 protein CTD PMID:9328168 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO sinigrin inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:28483571 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO sinigrin inhibits the reaction [TNF protein affects the localization of RELA protein]; sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:28483571 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:28483571 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        epitope 7009
          beta-D-glucose 1627
            1-thio-beta-D-glucopyranose 14
              beta-D-thioglucoside 14
                glucosinolic acid 14
                  6-sinapoylglucoraphenin 0
                  Glucoarabin 0
                  Glucohirsutin 0
                  alkenylglucosinolic acid + 5
                  alkylglucosinolic acid + 7
                  aralkylglucosinolic acid + 0
                  glucoibarin 0
                  glucoraphenin + 0
                  hydroxy-alkenylglucosinolic acid + 0
                  hydroxy-alkylglucosinolic acid + 0
                  indolylmethylglucosinolic acid + 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            heteroorganic entity 19591
                              organochalcogen compound 19339
                                organooxygen compound 19273
                                  carbohydrates and carbohydrate derivatives 13952
                                    carbohydrate 13936
                                      monosaccharide 4373
                                        aldose 2715
                                          aldohexose 2358
                                            glucose 2318
                                              D-glucose 2318
                                                D-glucopyranose 1766
                                                  beta-D-glucose 1627
                                                    1-thio-beta-D-glucopyranose 14
                                                      beta-D-thioglucoside 14
                                                        desulfoglucosinolic acid 14
                                                          glucosinolic acid 14
                                                            6-sinapoylglucoraphenin 0
                                                            Glucoarabin 0
                                                            Glucohirsutin 0
                                                            alkenylglucosinolic acid + 5
                                                            alkylglucosinolic acid + 7
                                                            aralkylglucosinolic acid + 0
                                                            glucoibarin 0
                                                            glucoraphenin + 0
                                                            hydroxy-alkenylglucosinolic acid + 0
                                                            hydroxy-alkylglucosinolic acid + 0
                                                            indolylmethylglucosinolic acid + 4
paths to the root