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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glucosinolic acid
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Accession:CHEBI:79316 term browser browse the term
Definition:A glycosinolic acid derived from glucose. Glucosinolic acids have a central C atom which is bonded via an S atom to a glucosyl group and via an N atom to a sulfonated oxime group, and which also carries a side-group. The side-chain and sulfate group have an anti stereochemical configuration across the C=N double bond.
Synonyms:related_synonym: Formula=C7H12NO9S2R;   SMILES=[C@H]1(O[C@@H]([C@@H](O)[C@@H]([C@H]1O)O)CO)S/C(=N\\OS(O)(=O)=O)/*;   glucosinolic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:24279

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glucobrassicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpx2 glutathione peroxidase 2 multiple interactions
decreases expression		 ISO glucobrassicin analog inhibits the reaction [glucoraphanin analog results in increased expression of GPX2 mRNA]
glucobrassicin analog results in decreased expression of GPX2 protein		 CTD PMID:20868228 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
decreases activity		 ISO glucobrassicin analog inhibits the reaction [glucoraphanin results in increased activity of NQO1 protein]
glucobrassicin analog results in decreased activity of NQO1 protein		 CTD PMID:20868228 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
glucoerucin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP glucoerucin results in increased expression of CYP1A1 protein CTD PMID:20833222 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP glucoerucin results in increased expression of CYP1A2 protein CTD PMID:20833222 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP glucoerucin results in increased expression of CYP1B1 protein CTD PMID:20833222 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP glucoerucin results in increased expression of EPHX1 protein CTD PMID:21132492 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP glucoerucin results in increased activity of NQO1 protein CTD PMID:20833222 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
glucoraphanin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP glucoraphanin results in increased expression of CYP1A1 protein CTD PMID:20833222 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP glucoraphanin results in increased expression of CYP1A2 protein CTD PMID:20833222 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP glucoraphanin results in increased expression of CYP1B1 protein CTD PMID:20833222 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP glucoraphanin results in increased expression of EPHX1 protein CTD PMID:21132492 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression
multiple interactions		 ISO glucoraphanin analog results in increased expression of GPX2 mRNA; glucoraphanin analog results in increased expression of GPX2 protein
Benzo(a)pyrene inhibits the reaction [glucoraphanin results in increased expression of GPX2 mRNA]; glucobrassicin analog inhibits the reaction [glucoraphanin analog results in increased expression of GPX2 mRNA]		 CTD PMID:20868228 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO glucoraphanin analog affects the localization of NFE2L2 protein CTD PMID:20868228 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases activity		 ISO
EXP		 glucobrassicin analog inhibits the reaction [glucoraphanin results in increased activity of NQO1 protein]
glucoraphanin analog results in increased activity of NQO1 protein		 CTD PMID:20833222 PMID:20868228 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
neoglucobrassicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis ISO 1-methoxy-3-indolylmethylglucosinolate metabolite results in increased mutagenesis of HPRT1 gene CTD PMID:20846518 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases response to substance ISO SULT1A1 protein results in increased susceptibility to 1-methoxy-3-indolylmethylglucosinolate metabolite CTD PMID:20846518 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
sinigrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr7a3 aldo-keto reductase family 7 member A3 increases activity EXP sinigrin results in increased activity of AKR7A3 protein CTD PMID:9328168 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases activity EXP sinigrin results in increased activity of GSTA5 protein CTD PMID:9328168 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO sinigrin inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:28483571 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO sinigrin inhibits the reaction [TNF protein affects the localization of RELA protein]; sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:28483571 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:28483571 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        epitope 6844
          beta-D-glucose 1607
            1-thio-beta-D-glucopyranose 14
              beta-D-thioglucoside 14
                glucosinolic acid 14
                  6-sinapoylglucoraphenin 0
                  Glucoarabin 0
                  Glucohirsutin 0
                  alkenylglucosinolic acid + 5
                  alkylglucosinolic acid + 7
                  aralkylglucosinolic acid + 0
                  glucoibarin 0
                  glucoraphenin + 0
                  hydroxy-alkenylglucosinolic acid + 0
                  hydroxy-alkylglucosinolic acid + 0
                  indolylmethylglucosinolic acid + 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            heteroorganic entity 19217
                              organochalcogen compound 18922
                                organooxygen compound 18846
                                  carbohydrates and carbohydrate derivatives 12248
                                    carbohydrate 12248
                                      monosaccharide 4175
                                        aldose 2555
                                          aldohexose 2196
                                            glucose 2158
                                              D-glucose 2158
                                                D-glucopyranose 1718
                                                  beta-D-glucose 1607
                                                    1-thio-beta-D-glucopyranose 14
                                                      beta-D-thioglucoside 14
                                                        desulfoglucosinolic acid 14
                                                          glucosinolic acid 14
                                                            6-sinapoylglucoraphenin 0
                                                            Glucoarabin 0
                                                            Glucohirsutin 0
                                                            alkenylglucosinolic acid + 5
                                                            alkylglucosinolic acid + 7
                                                            aralkylglucosinolic acid + 0
                                                            glucoibarin 0
                                                            glucoraphenin + 0
                                                            hydroxy-alkenylglucosinolic acid + 0
                                                            hydroxy-alkylglucosinolic acid + 0
                                                            indolylmethylglucosinolic acid + 4
paths to the root