|
G |
Gpx2 |
glutathione peroxidase 2 |
multiple interactions decreases expression |
ISO |
glucobrassicin analog inhibits the reaction [glucoraphanin analog results in increased expression of GPX2 mRNA] glucobrassicin analog results in decreased expression of GPX2 protein |
CTD |
PMID:20868228 |
|
NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions decreases activity |
ISO |
glucobrassicin analog inhibits the reaction [glucoraphanin results in increased activity of NQO1 protein] glucobrassicin analog results in decreased activity of NQO1 protein |
CTD |
PMID:20868228 |
|
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
|
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
EXP |
glucoerucin results in increased expression of CYP1A1 protein |
CTD |
PMID:20833222 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP |
glucoerucin results in increased expression of CYP1A2 protein |
CTD |
PMID:20833222 |
|
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
EXP |
glucoerucin results in increased expression of CYP1B1 protein |
CTD |
PMID:20833222 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
|
|
G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
glucoerucin results in increased expression of EPHX1 protein |
CTD |
PMID:21132492 |
|
NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity |
EXP |
glucoerucin results in increased activity of NQO1 protein |
CTD |
PMID:20833222 |
|
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
|
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
EXP |
glucoraphanin results in increased expression of CYP1A1 protein |
CTD |
PMID:20833222 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP |
glucoraphanin results in increased expression of CYP1A2 protein |
CTD |
PMID:20833222 |
|
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
EXP |
glucoraphanin results in increased expression of CYP1B1 protein |
CTD |
PMID:20833222 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
|
|
G |
Ephx1 |
epoxide hydrolase 1 |
increases expression |
EXP |
glucoraphanin results in increased expression of EPHX1 protein |
CTD |
PMID:21132492 |
|
NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
|
|
G |
Gpx2 |
glutathione peroxidase 2 |
increases expression multiple interactions |
ISO |
glucoraphanin analog results in increased expression of GPX2 mRNA; glucoraphanin analog results in increased expression of GPX2 protein Benzo(a)pyrene inhibits the reaction [glucoraphanin results in increased expression of GPX2 mRNA]; glucobrassicin analog inhibits the reaction [glucoraphanin analog results in increased expression of GPX2 mRNA] |
CTD |
PMID:20868228 |
|
NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
|
|
G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
affects localization |
ISO |
glucoraphanin analog affects the localization of NFE2L2 protein |
CTD |
PMID:20868228 |
|
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases activity |
ISO EXP |
glucobrassicin analog inhibits the reaction [glucoraphanin results in increased activity of NQO1 protein] glucoraphanin analog results in increased activity of NQO1 protein |
CTD |
PMID:20833222 PMID:20868228 |
|
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
|
|
|
G |
Hprt1 |
hypoxanthine phosphoribosyltransferase 1 |
increases mutagenesis |
ISO |
1-methoxy-3-indolylmethylglucosinolate metabolite results in increased mutagenesis of HPRT1 gene |
CTD |
PMID:20846518 |
|
NCBI chr X:158,196,640...158,228,815
Ensembl chr X:158,197,149...158,228,749
|
|
G |
Sult1a1 |
sulfotransferase family 1A member 1 |
increases response to substance |
ISO |
SULT1A1 protein results in increased susceptibility to 1-methoxy-3-indolylmethylglucosinolate metabolite |
CTD |
PMID:20846518 |
|
NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
|
|
|
G |
Akr7a3 |
aldo-keto reductase family 7 member A3 |
increases activity |
EXP |
sinigrin results in increased activity of AKR7A3 protein |
CTD |
PMID:9328168 |
|
NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
|
|
G |
Gsta5 |
glutathione S-transferase alpha 5 |
increases activity |
EXP |
sinigrin results in increased activity of GSTA5 protein |
CTD |
PMID:9328168 |
|
NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
sinigrin inhibits the reaction [TNF protein affects the localization of RELA protein] |
CTD |
PMID:28483571 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
sinigrin inhibits the reaction [TNF protein affects the localization of RELA protein]; sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] |
CTD |
PMID:28483571 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
|
|
G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; sinigrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] |
CTD |
PMID:28483571 |
|
NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
|
|