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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Pargyline
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Accession:CHEBI:7930 term browser browse the term
Definition:An aromatic amine that has formula C11H13N.
Synonyms:related_synonym: Formula=C11H13N;   InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3;   InChIKey=DPWPWRLQFGFJFI-UHFFFAOYSA-N;   N-Methyl-N-benzylpropynylamine;   SMILES=CN(CC#C)Cc1ccccc1;   eutonyl;   pargylamine;   pargylin;   pargyline HCl;   pargyline hydrochloride;   supirdyl
 xref: CAS:555-57-7;   Drug_Central:2065;   HMDB:HMDB0015563;   KEGG:C07414;   KEGG:D08453;   LINCS:LSM-3878
 xref_mesh: MESH:D010293


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Pargyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col6a1 collagen type VI alpha 1 chain multiple interactions ISO Pargyline inhibits the reaction [COL6A1 protein affects the abundance of Reactive Oxygen Species] CTD PMID:20716577 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity
ISO Pargyline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
Pargyline results in decreased activity of CYP2B6 protein
CTD PMID:25656918 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH protein results in increased susceptibility to Pargyline CTD PMID:15148402 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Maoa monoamine oxidase A decreases activity
multiple interactions
ISO Pargyline results in decreased activity of MAOA protein
[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]
CTD PMID:20716577 PMID:23499958 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Maob monoamine oxidase B decreases activity
multiple interactions
ISO Pargyline results in decreased activity of MAOB protein
[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [Resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]
CTD PMID:20716577 PMID:23499958 PMID:27270453 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [Resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein] CTD PMID:23499958 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      chemical role 19345
        base 17286
          Bronsted base 17286
            organic amino compound 17278
              aromatic amine 13704
                Pargyline 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        aromatic amine 13704
                                          Pargyline 6
paths to the root