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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:17beta-estradiol 17-glucosiduronic acid
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Accession:CHEBI:791 term browser browse the term
Definition:A steroid glucosiduronic acid that consists of 17beta-estradiol having a beta-glucuronyl residue attached at position 17 via a glycosidic linkage.
Synonyms:exact_synonym: 3-hydroxyestra-1,3,5(10)-trien-17beta-yl beta-D-glucopyranosiduronic acid
 related_synonym: 17beta-Estradiol 17-(beta-D-glucuronide);   17beta-Estradiol glucuronide;   Formula=C24H32O8;   Glucuronosylestradiol;   InChI=1S/C24H32O8/c1-24-9-8-14-13-5-3-12(25)10-11(13)2-4-15(14)16(24)6-7-17(24)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1;   InChIKey=MTKNDAQYHASLID-QXYWQCSFSA-N;   Oestradiol-17beta-glucuronide;   SMILES=[H][C@]12CC[C@]3(C)[C@H](CC[C@@]3([H])[C@]1([H])CCc1cc(O)ccc21)O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O;   estra-1,3,5(10)-triene-3,17beta-diol 17-D-glucuronoside
 xref: CAS:1806-98-0;   HMDB:HMDB0010317;   KEGG:C11237;   LIPID_MAPS_instance:LMST05010015;   LIPID_MAPS_instance:LMST05010025
 xref_mesh: MESH:C025483
 xref: PMID:11812141;   PMID:11837698;   PMID:12527806;   PMID:12751626;   PMID:14567633;   PMID:15537867;   PMID:15608133;   PMID:20124397;   PMID:20360303;   PMID:20374298;   Reaxys:64569
 cyclic_relationship: is_conjugate_acid_of CHEBI:82961



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17beta-estradiol 17-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 increases uptake
multiple interactions
ISO ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide
Adenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Digoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; dofequidar inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; ochratoxin A inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Probenecid inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Verapamil inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]
CTD PMID:12379217 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
decreases secretion
affects localization
multiple interactions
EXP estradiol-17 beta-glucuronide results in decreased activity of ABCB11 protein
estradiol-17 beta-glucuronide results in decreased secretion of ABCB11 protein
estradiol-17 beta-glucuronide affects the localization of ABCB11 protein
estradiol-17 beta-glucuronide affects the localization of and affects the activity of ABCB11 protein; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]
CTD PMID:10869290 PMID:12702498 PMID:12893835 PMID:15763547 PMID:18972403 More... NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
multiple interactions
increases transport
ISO
EXP
ABCB1 affects the susceptibility to estradiol-17 beta-glucuronide
Daunorubicin inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]; estriol 17-glucuronide inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]; estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]
CTD PMID:9794924 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 affects export ISO ABCB4 protein affects the export of estradiol-17 beta-glucuronide CTD PMID:11302927 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects transport
increases export
multiple interactions
increases uptake
increases transport
ISO ABCC1 protein affects the transport of estradiol-17 beta-glucuronide
ABCC1 protein results in increased export of estradiol-17 beta-glucuronide
[Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; [Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]; BAY u9773 inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; BAY u9773 inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; estradiol-17 beta-glucuronide inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein mutant form]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein]; estradiol-17 beta-glucuronide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; kaempferol affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Quercetin affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; S-decylglutathione inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; S-decylglutathione inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]
ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide; ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide
CTD PMID:11278867 PMID:11306701 PMID:15459206 PMID:18336795 PMID:21918036 More... NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
decreases secretion
affects localization
affects transport
multiple interactions
increases transport
affects response to substance
ISO
EXP
ABCC2 protein affects the export of estradiol-17 beta-glucuronide
estradiol-17 beta-glucuronide results in decreased secretion of ABCC2 protein
estradiol-17 beta-glucuronide affects the localization of ABCC2 protein
ABCC2 protein affects the transport of estradiol-17 beta-glucuronide
abietic acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]; AG 1879 inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; Bucladesine inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; CL 387785 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; EGF protein inhibits the reaction [Fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]]; EGFR protein promotes the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein; Fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; Glycyrrhetinic Acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]
ABCC2 protein modified form results in increased transport of estradiol-17 beta-glucuronide; ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide
ABCC2 protein affects the susceptibility to estradiol-17 beta-glucuronide
[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; [SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of estradiol-17 beta-glucuronide; [SLCO1B1 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; Bile Acids and Salts promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; estradiol-17 beta-glucuronide promotes the reaction [ABCC2 protein affects the transport of Bile Acids and Salts]; estradiol-17 beta-glucuronide results in decreased activity of and affects the localization of ABCC2 protein; Ethinyl Estradiol metabolite promotes the reaction [ABCC2 protein results in increased uptake of estradiol-17 beta-glucuronide]; Furosemide promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Indomethacin promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Pantoprazole promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Penicillin G promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; sulfanitran promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide]
CTD PMID:11500505 PMID:12029626 PMID:12642476 PMID:12702498 PMID:12702717 More... NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 affects transport
multiple interactions
increases transport
increases activity
ISO ABCC3 protein affects the transport of estradiol-17 beta-glucuronide
Bile Acids and Salts inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Ethinyl Estradiol metabolite promotes the reaction [ABCC3 protein results in increased uptake of estradiol-17 beta-glucuronide]; Furosemide inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Indomethacin inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; resveratrol metabolite promotes the reaction [ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide]; resveratrol-4'-O-glucuronide inhibits the reaction [ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide]
estradiol-17 beta-glucuronide results in increased activity of ABCC3 protein
CTD PMID:12704183 PMID:14722317 PMID:17569508 PMID:19114588 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases transport
affects export
increases export
ISO ABCC4 protein results in increased transport of estradiol-17 beta-glucuronide
ABCC4 gene SNP affects the export of estradiol-17 beta-glucuronide
ABCC4 protein results in increased export of estradiol-17 beta-glucuronide
CTD PMID:11856762 PMID:27659809 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases transport
multiple interactions
ISO ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide
Glycyrrhetinic Acid inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide]; lapatinib inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide]
CTD PMID:18436619 PMID:18829547 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP estradiol-17 beta-glucuronide results in increased phosphorylation of AKT1 protein
tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of AKT1 protein]
CTD PMID:29090346 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aqp8 aquaporin 8 decreases expression EXP estradiol-17 beta-glucuronide results in decreased expression of AQP8 protein CTD PMID:17110522 NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
JBrowse link
G Egf epidermal growth factor multiple interactions EXP EGF protein inhibits the reaction [fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]] CTD PMID:25813982 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP EGFR protein promotes the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:25813982 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of ESR1 protein CTD PMID:25813982 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Hgf hepatocyte growth factor multiple interactions
increases uptake
EXP [HGF protein results in increased expression of SLCO1A1 protein] which results in increased uptake of estradiol-17 beta-glucuronide; ochratoxin A inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; SLCO1A1 protein affects the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; Sulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
increases phosphorylation
EXP 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of IGF1R protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein] CTD PMID:29090346 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Ocln occludin affects localization EXP estradiol-17 beta-glucuronide affects the localization of OCLN protein CTD PMID:17463180 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
affects localization
EXP Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of PRKCA protein] CTD PMID:18972403 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
affects transport
EXP
ISO
estradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]
SLC22A8 protein affects the transport of estradiol-17 beta-glucuronide
CTD PMID:11306713 PMID:15319347 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects uptake
increases uptake
multiple interactions
ISO
EXP
SLCO1A4 protein affects the uptake of estradiol-17 beta-glucuronide
SLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide
Bile Acids and Salts inhibits the reaction [SLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide]
CTD PMID:19464309 PMID:21561886 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases uptake
increases import
multiple interactions
affects response to substance
EXP
ISO
SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide
SLCO1B3 results in increased import of estradiol-17 beta-glucuronide
2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; pentabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide]
SLCO1B2 protein affects the susceptibility to estradiol-17 beta-glucuronide
Bile Acids and Salts inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide]
CTD PMID:18180276 PMID:18296417 PMID:19464309 PMID:20176623 PMID:32003934 More... NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein; Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein] CTD PMID:25813982 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tjp1 tight junction protein 1 affects localization EXP estradiol-17 beta-glucuronide affects the localization of TJP1 protein CTD PMID:17463180 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link

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  CHEBI ontology 20050
    role 20001
      application 19737
        pharmaceutical 19610
          drug 19610
            protective agent 17980
              geroprotector 16930
                17beta-estradiol 9898
                  17beta-estradiol 17-glucosiduronic acid 23
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  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            heteroorganic entity 19544
                              organochalcogen compound 19283
                                organooxygen compound 19228
                                  carbohydrates and carbohydrate derivatives 13915
                                    carbohydrate 13915
                                      carbohydrate derivative 13640
                                        glycosyl compound 12897
                                          glycoside 11736
                                            glycosiduronic acid 166
                                              glucosiduronic acid 166
                                                steroid glucosiduronic acid 25
                                                  17beta-estradiol 17-glucosiduronic acid 23
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