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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
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Accession:CHEBI:79091 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24).
Synonyms:related_synonym: ATP:protein phosphotransferase (MAPKK-activated) inhibitor;   ATP:protein phosphotransferase (MAPKK-activated) inhibitors;   Dp38 inhibitor;   Dp38 inhibitors;   EC 2.7.11.24 (mitogen-activated protein kinase) inhibitors;   EC 2.7.11.24 inhibitor;   EC 2.7.11.24 inhibitors;   ERK inhibitor;   ERK inhibitors;   ERK1 inhibitor;   ERK1 inhibitors;   ERK2 inhibitor;   ERK2 inhibitors;   JNK inhibitor;   JNK inhibitors;   JNK3alpha1 inhibitor;   JNK3alpha1 inhibitors;   LeMPK3 inhibitor;   LeMPK3 inhibitors;   MAP kinase inhibitor;   MAP kinase inhibitors;   MAP-2 kinase inhibitor;   MAP-2 kinase inhibitors;   MAPK inhibitor;   MAPK inhibitors;   MBP kinase I inhibitor;   MBP kinase I inhibitors;   MBP kinase II inhibitor;   MBP kinase II inhibitors;   MEK inhibitor;   MEK inhibitors;   PMK-1 inhibitor;   PMK-1 inhibitors;   PMK-2 inhibitor;   PMK-2 inhibitors;   PMK-3 inhibitor;   PMK-3 inhibitors;   SAPK inhibitor;   SAPK inhibitors;   STK26 inhibitor;   STK26 inhibitors;   c-Jun N-terminal kinase inhibitor;   c-Jun N-terminal kinase inhibitors;   extracellular signal-regulated kinase inhibitor;   extracellular signal-regulated kinase inhibitors;   microtubule-associated protein 2 kinase inhibitor;   microtubule-associated protein 2 kinase inhibitors;   microtubule-associated protein kinase inhibitor;   microtubule-associated protein kinase inhibitors;   mitogen-activated protein kinase inhibitor;   mitogen-activated protein kinase inhibitors;   myelin basic protein kinase inhibitor;   myelin basic protein kinase inhibitors;   p38-2 inhibitor;   p38-2 inhibitors;   p38delta inhibitor;   p38delta inhibitors;   p42 mitogen-activated protein kinase inhibitor;   p42 mitogen-activated protein kinase inhibitors;   p42(mapk) inhibitor;   p42(mapk) inhibitors;   p44mpk inhibitor;   p44mpk inhibitors;   pp42 inhibitor;   pp42 inhibitors;   pp44(mapk) inhibitor;   pp44(mapk) inhibitors;   stress-activated protein kinase inhibitor;   stress-activated protein kinase inhibitors
 alt_id: CHEBI:75997
 xref: Wikipedia:MEK_inhibitor;   Wikipedia:Mitogen-activated_protein_kinase


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4',5,7-trihydroxy-3'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 decreases activity ISO chrysoeriol results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein] CTD PMID:20553787 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Bglap bone gamma carboxyglutamate protein multiple interactions EXP chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein] CTD PMID:20981859 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:20553787 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:20553787 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:20553787 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Il6 interleukin 6 multiple interactions EXP chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein] CTD PMID:20981859 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Mtnr1a melatonin receptor 1A affects binding ISO chrysoeriol binds to MTNR1A protein CTD PMID:20399199 NCBI chr 8:45,069,107...45,089,233
Ensembl chr 8:45,069,137...45,088,506
JBrowse link
G Mtnr1b melatonin receptor 1B affects binding ISO chrysoeriol binds to MTNR1B protein CTD PMID:20399199 NCBI chr 9:15,862,614...15,874,556
Ensembl chr 9:15,824,528...15,874,556
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 multiple interactions ISO chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3] CTD PMID:20399199 NCBI chr13:33,964,655...33,988,465
Ensembl chr13:33,964,687...33,988,443
JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions EXP chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein] CTD PMID:20981859 NCBI chr14:78,277,446...78,308,043
Ensembl chr14:78,277,445...78,308,043
JBrowse link
6-hydroxyluteolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases chemical synthesis
ISO [CYP1A1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin
CYP1A1 protein results in increased chemical synthesis of 6-hydroxyluteolin
CTD PMID:19666078 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases chemical synthesis
multiple interactions
ISO CYP1B1 protein results in increased chemical synthesis of 6-hydroxyluteolin
[CYP1B1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin
CTD PMID:19666078 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
anthra[1,9-cd]pyrazol-6(2H)-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions ISO pyrazolanthrone inhibits the reaction [MAP3K1 protein results in increased expression of ABCB1 mRNA]; pyrazolanthrone inhibits the reaction [Oxygen deficiency results in increased expression of ABCB1 mRNA]
pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; pyrazolanthrone inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein]
CTD PMID:15604272 PMID:18474546 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]]; pyrazolanthrone inhibits the reaction [2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]]; pyrazolanthrone inhibits the reaction [7-Ala-angiotensin (1-7) inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]]; pyrazolanthrone inhibits the reaction [7-Ala-angiotensin (1-7) inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]] CTD PMID:27302421 NCBI chr  X:164,139,342...164,188,418
Ensembl chr  X:164,139,332...164,188,420
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO pyrazolanthrone inhibits the reaction [Streptozocin results in increased activity of ACHE protein] CTD PMID:20600246 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions EXP crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]; pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein] CTD PMID:30580027 NCBI chr 9:22,126,727...22,135,746
Ensembl chr 9:22,126,727...22,135,711
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions EXP 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in increased expression of ACTA2 protein]] CTD PMID:31447676 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA] CTD PMID:18577375 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein] CTD PMID:33075463 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of AGTR1 mRNA] CTD PMID:23603059 NCBI chr13:30,336,356...30,382,867
Ensembl chr13:30,336,441...30,382,867
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO pyrazolanthrone binds to and results in increased activity of AHR protein CTD PMID:17959153 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [arsenic trioxide affects the localization of AIFM1 protein]
pyrazolanthrone inhibits the reaction [cadmium acetate affects the localization of AIFM1 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein]
pyrazolanthrone inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein]
CTD PMID:18412143 PMID:20423716 PMID:24577723 PMID:25043952 PMID:29289695 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) multiple interactions ISO pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] CTD PMID:17640564 NCBI chr 6:34,303,930...34,317,489
Ensembl chr 6:34,302,434...34,317,478
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein]; pyrazolanthrone inhibits the reaction [arsenic trioxide results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; pyrazolanthrone inhibits the reaction [cholix toxin, Vibrio cholerae results in increased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [diallyl trisulfide results in decreased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased phosphorylation of AKT1 protein]
pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of AKT1 protein]
pyrazolanthrone results in decreased expression of AKT1 protein
CTD PMID:16046226 PMID:17341418 PMID:20534739 PMID:22020565 PMID:22696236 PMID:25939952 PMID:28087840 PMID:33771252 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Akt2 thymoma viral proto-oncogene 2 multiple interactions EXP [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA] CTD PMID:30580027 NCBI chr 7:27,591,552...27,640,826
Ensembl chr 7:27,591,552...27,640,826
JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases expression ISO pyrazolanthrone results in decreased expression of ALOX5 protein CTD PMID:23539630 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of AMPD3 mRNA] CTD PMID:17460151 NCBI chr 7:110,767,790...110,812,409
Ensembl chr 7:110,768,206...110,812,405
JBrowse link
G Apoa1 apolipoprotein A-I multiple interactions ISO pyrazolanthrone inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein] CTD PMID:19013290 NCBI chr 9:46,228,630...46,230,469
Ensembl chr 9:46,228,580...46,230,466
JBrowse link
G Apod apolipoprotein D multiple interactions ISO pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of APOD mRNA]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of APOD protein] CTD PMID:21688324 NCBI chr16:31,296,192...31,314,808
Ensembl chr16:31,296,192...31,314,808
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions ISO pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]; pyrazolanthrone inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein]; pyrazolanthrone inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of IL1B protein]; pyrazolanthrone inhibits the reaction [APP protein results in increased expression of NLRP3 protein] CTD PMID:16648635 PMID:28004443 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of AQP1 protein] CTD PMID:21647617 NCBI chr 6:55,336,299...55,348,555
Ensembl chr 6:55,336,432...55,348,555
JBrowse link
G Ar androgen receptor multiple interactions ISO pyrazolanthrone affects the reaction [Quercetin inhibits the reaction [mibolerone results in increased expression of AR protein]] CTD PMID:20148354 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [ATF2 protein results in decreased susceptibility to Cisplatin]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [Cisplatin results in increased activity of ATF2 protein]; pyrazolanthrone inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of ATF2 protein]; pyrazolanthrone inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ATF2 protein]
pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [trovafloxacin results in increased phosphorylation of ATF2 protein]
CTD PMID:12393500 PMID:12663670 PMID:22003962 PMID:23591579 PMID:23836369 PMID:24469321 PMID:24525298 PMID:28975372 PMID:30768131 NCBI chr 2:73,816,509...73,892,677
Ensembl chr 2:73,816,509...73,892,639
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of ATF3 protein]
pyrazolanthrone inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of ATF3 protein]
CTD PMID:22003962 PMID:25531190 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of ATF4 mRNA] CTD PMID:20920558 NCBI chr15:80,255,184...80,257,545
Ensembl chr15:80,255,184...80,257,541
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in increased expression of BAD protein] CTD PMID:19747539 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899
JBrowse link
G Bag3 BCL2-associated athanogene 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 protein] CTD PMID:22020323 NCBI chr 7:128,523,583...128,546,981
Ensembl chr 7:128,523,616...128,546,981
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [docetaxel results in increased activity of BAK1 protein] CTD PMID:17317842 NCBI chr17:27,019,812...27,028,627
Ensembl chr17:27,019,810...27,029,009
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO
EXP
[U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; MYC affects the reaction [pyrazolanthrone results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [Docetaxel results in increased activity of BAX protein]; pyrazolanthrone inhibits the reaction [fisetin results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in increased expression of BAX protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased activity of and results in increased localization of BAX protein]
pyrazolanthrone inhibits the reaction [bakuchiol affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of BAX protein]
pyrazolanthrone inhibits the reaction [Acetaminophen affects the localization of BAX protein]; pyrazolanthrone inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]
CTD PMID:14514659 PMID:15034932 PMID:16046226 PMID:16972261 PMID:17292878 PMID:17317842 PMID:19428505 PMID:19540902 PMID:19954742 PMID:20423716 PMID:21420390 PMID:24036456 PMID:24577723 PMID:25043952 PMID:29289695 PMID:30653946 PMID:31044527 PMID:33684387 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bbc3 BCL2 binding component 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of BBC3 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of BBC3 protein] CTD PMID:30472098 PMID:32540572 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205
JBrowse link
G Bcas2 BCAS2 pre-mRNA processing factor multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of BCAS2 mRNA] CTD PMID:17460151 NCBI chr 3:103,171,655...103,179,163
Ensembl chr 3:103,171,655...103,179,166
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases phosphorylation
ISO
EXP
pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased phosphorylation of BCL2 protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of BCL2 protein]; pyrazolanthrone inhibits the reaction [Docetaxel results in increased phosphorylation of BCL2 protein]; pyrazolanthrone inhibits the reaction [fosbretabulin results in increased phosphorylation of BCL2 protein]; pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [trimethyltin chloride results in decreased expression of BCL2 protein]
pyrazolanthrone results in decreased phosphorylation of BCL2 protein
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in decreased expression of BCL2 mRNA]; pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of BCL2 protein modified form]; pyrazolanthrone inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]; pyrazolanthrone results in increased phosphorylation of and results in decreased activity of BCL2 protein
pyrazolanthrone inhibits the reaction [Cardiotoxins results in increased phosphorylation of BCL2 protein]
CTD PMID:14724571 PMID:17317842 PMID:17786558 PMID:18412143 PMID:19428505 PMID:19540902 PMID:19747539 PMID:19954742 PMID:20166895 PMID:20920558 PMID:21420390 PMID:23212307 PMID:23423712 PMID:24036456 PMID:24321340 PMID:24577723 PMID:24833599 PMID:25043952 PMID:25446857 PMID:30472098 PMID:30653946 PMID:30871965 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO [pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [Arachidonic Acid results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in decreased expression of BCL2L1 protein]
pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of BCL2L1 protein modified form]
CTD PMID:18281123 PMID:19540902 PMID:19747539 PMID:20166895 PMID:31044527 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of BCL2L11 protein]
pyrazolanthrone inhibits the reaction [docetaxel results in increased degradation of BCL2L11 protein]; pyrazolanthrone inhibits the reaction [Lovastatin results in increased expression of BCL2L11 protein]; pyrazolanthrone inhibits the reaction [Nimustine results in increased expression of BCL2L11 mRNA]; pyrazolanthrone inhibits the reaction [temozolomide results in increased expression of BCL2L11 mRNA]
CTD PMID:16166651 PMID:17317842 PMID:18766339 PMID:26418950 NCBI chr 2:128,126,038...128,162,547
Ensembl chr 2:128,126,038...128,162,547
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions ISO pyrazolanthrone inhibits the reaction [BDNF protein results in increased expression of SOD2 protein] CTD PMID:22261313 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions ISO pyrazolanthrone inhibits the reaction [Colistin results in increased expression of BECN1 protein]; pyrazolanthrone inhibits the reaction [decamethrin results in increased expression of BECN1 protein]
pyrazolanthrone promotes the reaction [polyphyllin I results in increased expression of BECN1 protein]
CTD PMID:26588882 PMID:28842171 PMID:31421117 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Bglap bone gamma carboxyglutamate protein multiple interactions ISO [pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of BGLAP protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of BGLAP protein] CTD PMID:26136938 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO pyrazolanthrone promotes the reaction [arsenic trioxide results in increased cleavage of BID protein] CTD PMID:16972261 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of BIRC2 mRNA] CTD PMID:12832416 NCBI chr 9:7,818,226...7,837,131
Ensembl chr 9:7,818,227...7,837,064
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO pyrazolanthrone inhibits the reaction [arsenic trioxide results in decreased expression of BIRC5 protein]; pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in decreased expression of BIRC5 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in decreased expression of BIRC5 mRNA]; pyrazolanthrone inhibits the reaction [sodium arsenite results in decreased expression of BIRC5 protein] CTD PMID:16328441 PMID:19747539 PMID:21594580 PMID:22706169 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of BNIP3 protein] CTD PMID:24824807 NCBI chr 7:138,890,836...138,909,506
Ensembl chr 7:138,890,836...138,909,519
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions ISO pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein] CTD PMID:21933187 NCBI chr18:60,925,307...60,988,152
Ensembl chr18:60,925,618...60,988,152
JBrowse link
G Capn1 calpain 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein] CTD PMID:29289695 NCBI chr19:5,988,545...6,015,825
Ensembl chr19:5,988,545...6,015,897
JBrowse link
G Capn2 calpain 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein] CTD PMID:29289695 NCBI chr 1:182,467,253...182,517,610
Ensembl chr 1:182,467,260...182,517,608
JBrowse link
G Casp1 caspase 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [irinotecan results in increased cleavage of CASP1 protein]
pyrazolanthrone inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein]
CTD PMID:26431797 PMID:28004443 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp12 caspase 12 multiple interactions ISO pyrazolanthrone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP12 protein] CTD PMID:24140863 NCBI chr 9:5,345,442...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Casp2 caspase 2 decreases activity ISO pyrazolanthrone results in decreased activity of CASP2 protein CTD PMID:17317842 NCBI chr 6:42,264,902...42,282,508
Ensembl chr 6:42,264,985...42,282,508
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
decreases activity
increases activity
ISO
EXP
[U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [8-bromo-7-methoxychrysin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[fludarabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Biological Products results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [Citrinin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [coronarin D results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Ketoconazole results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [morusin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Oxygen deficiency promotes the reaction [HBEGF protein mutant form results in increased activity of CASP3 protein]]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [Phytochemicals results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [polyphyllin I results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [dihydromyricetin results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [FAS protein results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP3 protein]
pyrazolanthrone results in increased expression of CASP3 protein modified form
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [bakuchiol results in increased activity of and results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [cadmium acetate results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [decamethrin results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [Isoflurane results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [satratoxin H results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; Taurine promotes the reaction [pyrazolanthrone inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]]
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in increased activity of CASP3 protein]]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Sodium Fluoride results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [TEMPO results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Tretinoin results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in increased activity of CASP3 protein]]
pyrazolanthrone results in decreased activity of CASP3 protein
pyrazolanthrone results in increased activity of CASP3 protein
CTD PMID:12393500 PMID:15034932 PMID:15095415 PMID:15254339 PMID:15501958 PMID:15767555 PMID:15831436 PMID:15850772 PMID:16061660 PMID:16310883 PMID:16322078 PMID:16357177 PMID:16712891 PMID:16787641 PMID:16843435 PMID:17292878 PMID:17341418 PMID:18281123 PMID:18703135 PMID:18767140 PMID:19193634 PMID:19361540 PMID:19631732 PMID:20632440 PMID:20830294 PMID:20920558 PMID:21165570 PMID:21295052 PMID:21600974 PMID:21843585 PMID:21843586 PMID:22654482 PMID:22863859 PMID:23082001 PMID:23212307 PMID:23405080 PMID:23416140 PMID:23578390 PMID:23836369 PMID:24036456 PMID:24111524 PMID:24157283 PMID:24577723 PMID:25043952 PMID:25078063 PMID:25305377 PMID:25446857 PMID:25882087 PMID:26588882 PMID:26630137 PMID:27539140 PMID:28383207 PMID:28391263 PMID:28474156 PMID:29289695 PMID:29968959 PMID:30259999 PMID:30871965 PMID:30928397 PMID:31044527 PMID:31421117 PMID:31447676 PMID:32574669 PMID:32652169 PMID:33035517 PMID:33684387 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase multiple interactions ISO pyrazolanthrone inhibits the reaction [Bortezomib results in increased cleavage of CASP4 protein] CTD PMID:16357177 NCBI chr 9:5,308,849...5,336,791
Ensembl chr 9:5,308,828...5,336,783
JBrowse link
G Casp6 caspase 6 multiple interactions ISO pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP6 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased activity of CASP6 protein]; pyrazolanthrone inhibits the reaction [surfactin peptide results in increased cleavage of and results in increased activity of CASP6 protein]
pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased activity of CASP6 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP6 protein]
CTD PMID:15501958 PMID:16310883 PMID:17341418 PMID:19954742 NCBI chr 3:129,901,415...129,914,112
Ensembl chr 3:129,901,425...129,914,103
JBrowse link
G Casp7 caspase 7 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; pyrazolanthrone promotes the reaction [dihydromyricetin results in increased cleavage of CASP7 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP7 protein]
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP7 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP7 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP7 protein]
pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased activity of CASP7 protein]; pyrazolanthrone inhibits the reaction [TEMPO results in increased activity of CASP7 protein]
CTD PMID:20920558 PMID:21843585 PMID:21843586 PMID:23405080 PMID:24157283 PMID:25078063 PMID:25882087 PMID:27539140 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp8 caspase 8 multiple interactions ISO pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CASP8 protein]; pyrazolanthrone inhibits the reaction [[Buthionine Sulfoximine co-treated with Arsenic Trioxide] results in increased cleavage of CASP8 protein]; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein]; pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP8 protein]; pyrazolanthrone inhibits the reaction [coronarin D results in increased expression of CASP8 protein modified form]; pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP8 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of CASP8 protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased activity of CASP8 protein]; pyrazolanthrone promotes the reaction [FAS protein results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:15501958 PMID:15767555 PMID:16061660 PMID:16972261 PMID:17145888 PMID:21138480 PMID:21165570 PMID:23212307 PMID:29968959 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO
EXP
pyrazolanthrone inhibits the reaction [5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CASP9 protein]; pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [coronarin D results in increased expression of CASP9 protein modified form]; pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [morusin results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of CASP9 protein]; pyrazolanthrone promotes the reaction [dihydromyricetin results in increased cleavage of CASP9 protein]
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP9 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP9 protein]
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [Cardiotoxins results in increased cleavage of CASP9 protein]
pyrazolanthrone results in increased activity of CASP9 protein
CTD PMID:15034932 PMID:15501958 PMID:15831436 PMID:16310883 PMID:16322078 PMID:17341418 PMID:17786558 PMID:20920558 PMID:21138480 PMID:21165570 PMID:21420390 PMID:21843586 PMID:23212307 PMID:27539140 PMID:29968959 PMID:33035517 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions ISO pyrazolanthrone promotes the reaction [Pyrogallol results in decreased expression of CAT protein] CTD PMID:20191265 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; pyrazolanthrone inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [Cyclosporine results in increased expression of CCL2 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [NR1H4 gene mutant form promotes the reaction [Taurocholic Acid results in increased expression of CCL2 mRNA]]; pyrazolanthrone inhibits the reaction [Palmitates results in increased secretion of CCL2 protein]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL2 protein]; pyrazolanthrone promotes the reaction [Ozone results in increased expression of CCL2 mRNA]
pyrazolanthrone inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]
pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased secretion of CCL2 protein]
CTD PMID:17460151 PMID:18303122 PMID:20354174 PMID:20712904 PMID:23958496 PMID:26641773 PMID:26862037 PMID:28087833 PMID:28505368 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 multiple interactions EXP pyrazolanthrone inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA] CTD PMID:23958496 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO [pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; pyrazolanthrone inhibits the reaction [fisetin results in decreased expression of CCN2 protein] CTD PMID:31044527 NCBI chr10:24,595,442...24,598,683
Ensembl chr10:24,595,442...24,598,683
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CCNB1 protein] CTD PMID:23212307 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCND1 mRNA]; pyrazolanthrone inhibits the reaction [kahweol results in decreased expression of CCND1 protein]; pyrazolanthrone inhibits the reaction [kahweol results in increased phosphorylation of CCND1 protein]
pyrazolanthrone results in decreased expression of CCND1 protein
CTD PMID:18593901 PMID:19801633 PMID:27424123 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccr2 chemokine (C-C motif) receptor 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein] CTD PMID:26163174 NCBI chr 9:124,101,918...124,109,140
Ensembl chr 9:124,101,950...124,113,557
JBrowse link
G Cd14 CD14 antigen multiple interactions ISO pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CD14 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein] CTD PMID:14729647 PMID:18180316 NCBI chr18:36,725,064...36,726,815
Ensembl chr18:36,725,067...36,726,798
JBrowse link
G Cd207 CD207 antigen multiple interactions
decreases expression
ISO pyrazolanthrone promotes the reaction [nickel sulfate results in decreased expression of CD207 protein]
pyrazolanthrone results in decreased expression of CD207 protein
CTD PMID:15588916 NCBI chr 6:83,671,207...83,677,857
Ensembl chr 6:83,671,215...83,677,857
JBrowse link
G Cd36 CD36 molecule multiple interactions EXP pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of CD36 mRNA] CTD PMID:21873422 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Cd80 CD80 antigen multiple interactions EXP pyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased expression of CD80 protein] CTD PMID:28235615 NCBI chr16:38,457,430...38,495,958
Ensembl chr16:38,455,561...38,496,335
JBrowse link
G Cd86 CD86 antigen multiple interactions EXP pyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased expression of CD86 protein] CTD PMID:28235615 NCBI chr16:36,568,956...36,666,158
Ensembl chr16:36,603,869...36,666,081
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO pyrazolanthrone inhibits the reaction [5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin affects the expression of CDC25C protein] CTD PMID:16179969 NCBI chr18:34,732,993...34,751,564
Ensembl chr18:34,732,993...34,751,533
JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions
ISO
EXP
pyrazolanthrone results in decreased expression of CDH1 protein
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in decreased expression of CDH1 protein]]; pyrazolanthrone inhibits the reaction [Folic Acid results in decreased expression of CDH1 protein]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in decreased expression of CDH1 protein]]
pyrazolanthrone promotes the reaction [nickel sulfate results in decreased expression of CDH1 protein]
CTD PMID:15588916 PMID:31447676 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO pyrazolanthrone inhibits the reaction [Varenicline results in decreased expression of CDH5] CTD PMID:28842382 NCBI chr 8:104,101,613...104,144,504
Ensembl chr 8:104,101,625...104,144,511
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CDK1 protein]
pyrazolanthrone results in decreased expression of CDK1 protein
CTD PMID:18593901 PMID:23212307 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Cdk2 cyclin-dependent kinase 2 multiple interactions
decreases activity
ISO pyrazolanthrone inhibits the reaction [naphtho(1,2-b)furan-4,5-dione results in decreased expression of CDK2 protein]
pyrazolanthrone results in decreased activity of CDK2 protein
CTD PMID:12534346 PMID:19747539 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031
JBrowse link
G Cdk5 cyclin-dependent kinase 5 multiple interactions ISO pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein]; pyrazolanthrone inhibits the reaction [troglitazone results in increased phosphorylation of CDK5 protein] CTD PMID:24481447 NCBI chr 5:24,407,597...24,423,587
Ensembl chr 5:24,418,241...24,423,530
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) multiple interactions EXP pyrazolanthrone inhibits the reaction [resveratrol results in decreased expression of CDK5R1 mRNA] CTD PMID:21736731 NCBI chr11:80,477,023...80,481,184
Ensembl chr11:80,477,023...80,481,184
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions
increases expression
ISO pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; pyrazolanthrone promotes the reaction [EGF protein results in increased expression of CDKN1A mRNA]
pyrazolanthrone promotes the reaction [Diethylnitrosamine results in increased expression of CDKN1A protein]
pyrazolanthrone results in increased expression of CDKN1A protein
CTD PMID:15961274 PMID:16061660 PMID:16283431 PMID:19418558 PMID:31734849 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A multiple interactions EXP pyrazolanthrone inhibits the reaction [Particulate Matter results in increased methylation of CDKN2A promoter] CTD PMID:22355787 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha multiple interactions ISO pyrazolanthrone inhibits the reaction [Glucose results in increased localization of and results in increased activity of CEBPA protein] CTD PMID:24376792 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928
JBrowse link
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta multiple interactions ISO pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CEBPB mRNA]; pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CEBPB protein]; pyrazolanthrone inhibits the reaction [Glucose results in increased localization of and results in increased activity of CEBPB protein] CTD PMID:14729647 PMID:24376792 NCBI chr 2:167,688,915...167,690,432
Ensembl chr 2:167,688,915...167,690,418
JBrowse link
G Cebpd CCAAT/enhancer binding protein (C/EBP), delta multiple interactions ISO pyrazolanthrone inhibits the reaction [Glucose results in increased localization of and results in increased activity of CEBPD protein] CTD PMID:24376792 NCBI chr16:15,887,286...15,889,545
Ensembl chr16:15,887,286...15,891,031
JBrowse link
G Ces3b carboxylesterase 3B multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of CES3 mRNA] CTD PMID:17460151 NCBI chr 8:105,083,733...105,093,929
Ensembl chr 8:105,083,753...105,093,929
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions ISO pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of CHUK protein] CTD PMID:19616567 NCBI chr19:44,073,334...44,107,505
Ensembl chr19:44,073,335...44,107,480
JBrowse link
G Cldn4 claudin 4 multiple interactions ISO pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 5:134,945,123...134,946,934
Ensembl chr 5:134,945,119...134,946,934
JBrowse link
G Cpeb1 cytoplasmic polyadenylation element binding protein 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of CPEB1 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CPEB1 mRNA] CTD PMID:21620800 NCBI chr 7:81,347,026...81,458,001
Ensembl chr 7:81,347,026...81,455,465
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1b, muscle increases expression
multiple interactions
EXP pyrazolanthrone results in increased expression of CPT1B mRNA
pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of CPT1B mRNA]
CTD PMID:21873422 NCBI chr15:89,416,405...89,425,862
Ensembl chr15:89,416,405...89,425,863
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions
ISO pyrazolanthrone results in decreased phosphorylation of CREB1 protein
pyrazolanthrone inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of Antimony] which results in increased phosphorylation of CREB1 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of CREB1 protein]
CTD PMID:25605016 PMID:28087833 PMID:32920012 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO pyrazolanthrone inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CRH mRNA] CTD PMID:28189027 NCBI chr 3:19,693,401...19,695,396
Ensembl chr 3:19,693,401...19,695,396
JBrowse link
G Cs citrate synthase multiple interactions EXP pyrazolanthrone affects the reaction [triethylene glycol dimethacrylate affects the activity of CS protein] CTD PMID:33684387 NCBI chr10:128,337,727...128,362,482
Ensembl chr10:128,337,734...128,362,479
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions ISO pyrazolanthrone inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein] CTD PMID:19460412 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Csnk1d casein kinase 1, delta decreases activity ISO pyrazolanthrone results in decreased activity of CSNK1D protein CTD PMID:12534346 NCBI chr11:120,957,709...120,991,350
Ensembl chr11:120,958,990...120,991,330
JBrowse link
G Cst3 cystatin C multiple interactions EXP 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of CST3 protein]]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of CST3 protein]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in increased expression of CST3 protein]] CTD PMID:31447676 NCBI chr 2:148,871,722...148,875,512
Ensembl chr 2:148,871,722...148,875,692
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein] CTD PMID:16507596 NCBI chr 7:127,712,676...127,718,188
Ensembl chr 7:127,712,736...127,718,192
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased secretion of CXCL1 protein] CTD PMID:28087833 NCBI chr 5:90,891,245...90,893,121
Ensembl chr 5:90,891,241...90,893,115
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of CXCL10 mRNA] CTD PMID:12832416 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
decreases expression
ISO pyrazolanthrone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [Allopurinol results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]]; pyrazolanthrone inhibits the reaction [cadmium acetate results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Diclofenac analog results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [IL1B results in increased expression of CXCL8 protein]; pyrazolanthrone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Smoke results in increased expression of CXCL8 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Sodium Fluoride results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [Vehicle Emissions results in increased expression of CXCL8 protein]; pyrazolanthrone inhibits the reaction [zinc chloride results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Zinc results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [Zinc results in increased expression of CXCL8 protein]; pyrazolanthrone results in decreased susceptibility to [Hydrogen Peroxide results in increased secretion of CXCL8 protein]
pyrazolanthrone results in decreased expression of CXCL8 protein
CTD PMID:12832416 PMID:16076765 PMID:16373669 PMID:19626664 PMID:20302854 PMID:20307528 PMID:20932985 PMID:21777978 PMID:21956143 PMID:23535185 PMID:24104198 PMID:25540590 PMID:26641773 PMID:26862037 PMID:27427241 PMID:27836898 PMID:30133131 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 multiple interactions EXP pyrazolanthrone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL2 protein] CTD PMID:21507677 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cyba cytochrome b-245, alpha polypeptide multiple interactions ISO pyrazolanthrone inhibits the reaction [Glucose results in increased expression of CYBA protein] CTD PMID:22245600 NCBI chr 8:122,424,771...122,432,940
Ensembl chr 8:122,424,776...122,432,930
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in increased expression of CYCS protein]; pyrazolanthrone inhibits the reaction [surfactin peptide affects the localization of CYCS protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide affects the localization of CYCS protein]
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]
CTD PMID:16322078 PMID:16972261 PMID:19954742 PMID:30653946 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cygb cytoglobin multiple interactions ISO pyrazolanthrone inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA] CTD PMID:25781201 NCBI chr11:116,645,595...116,654,504
Ensembl chr11:116,645,595...116,654,313
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP11A1 mRNA]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP11A1 protein]
pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]
CTD PMID:26209791 PMID:28697429 PMID:29567110 NCBI chr 9:57,998,024...58,027,031
Ensembl chr 9:58,006,411...58,027,023
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of CYP17A1 mRNA
pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]
pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of CYP17A1 mRNA]
CTD PMID:16269825 PMID:29567110 NCBI chr19:46,667,165...46,673,000
Ensembl chr19:46,667,165...46,673,172
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]
pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP19A1 mRNA]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of CYP19A1 protein]
pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein]
CTD PMID:20096755 PMID:20678559 PMID:28571770 PMID:28697429 NCBI chr 9:54,165,937...54,268,164
Ensembl chr 9:54,165,937...54,268,110
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression
increases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [pyrazolanthrone results in increased expression of CYP1A1 mRNA]
pyrazolanthrone results in decreased expression of CYP1A1 mRNA
pyrazolanthrone inhibits the reaction [Copper results in increased expression of CYP1A1 mRNA]; pyrazolanthrone inhibits the reaction [Lead results in increased expression of CYP1A1 mRNA]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; pyrazolanthrone promotes the reaction [Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; pyrazolanthrone promotes the reaction [Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; pyrazolanthrone promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]
CTD PMID:17959153 PMID:18078826 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of CYP1A2 mRNA
pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; resveratrol inhibits the reaction [pyrazolanthrone results in increased expression of CYP1A2 mRNA]
CTD PMID:17959153 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO pyrazolanthrone inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA] CTD PMID:24830941 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 multiple interactions ISO pyrazolanthrone inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA] CTD PMID:24830941 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Arachidonic Acid promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]]; pyrazolanthrone inhibits the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA] CTD PMID:22486562 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Tretinoin results in decreased expression of CYP7A1 mRNA]; pyrazolanthrone inhibits the reaction [Tretinoin results in decreased expression of CYP7A1 protein] CTD PMID:30709899 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [dihydrocapsaicin results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [leflunomide results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of DDIT3 mRNA]; pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of DDIT3 protein]
pyrazolanthrone inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]
pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of DDIT3 mRNA]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]
CTD PMID:17049495 PMID:17341418 PMID:19139269 PMID:20920558 PMID:24612139 PMID:26203587 PMID:28988120 PMID:30508555 PMID:31348969 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Dio1 deiodinase, iodothyronine, type I multiple interactions ISO [Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA] CTD PMID:16614379 NCBI chr 4:107,291,465...107,307,168
Ensembl chr 4:107,291,465...107,307,169
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of DNMT1 protein] CTD PMID:22355787 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Doc2b double C2, beta multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of DOC2B mRNA] CTD PMID:17460151 NCBI chr11:75,768,270...75,796,060
Ensembl chr11:75,768,966...75,796,049
JBrowse link
G Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a decreases activity ISO pyrazolanthrone results in decreased activity of DYRK1A protein CTD PMID:12534346 NCBI chr16:94,569,947...94,695,519
Ensembl chr16:94,570,010...94,695,517
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Glucose results in increased expression of EDN1 mRNA] CTD PMID:24376792 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Ednra endothelin receptor type A multiple interactions ISO pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein] CTD PMID:20561571 NCBI chr 8:77,663,029...77,724,452
Ensembl chr 8:77,663,031...77,724,464
JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO pyrazolanthrone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; pyrazolanthrone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]; pyrazolanthrone inhibits the reaction [Smoke analog results in increased expression of EDNRB protein] CTD PMID:20561571 PMID:20716444 PMID:26496744 NCBI chr14:103,814,615...103,844,508
Ensembl chr14:103,814,625...103,844,402
JBrowse link
G Egf epidermal growth factor multiple interactions ISO pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]; pyrazolanthrone promotes the reaction [EGF protein results in increased expression of CDKN1A mRNA] CTD PMID:15961274 PMID:21613822 PMID:22766066 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO pyrazolanthrone results in decreased expression of EGFR mRNA; pyrazolanthrone results in decreased expression of EGFR protein CTD PMID:15923621 PMID:18332871 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of EGR1 protein]
pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased expression of EGR1 mRNA]
CTD PMID:15688020 PMID:18316600 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein] CTD PMID:32574669 NCBI chr17:78,850,504...78,882,572
Ensembl chr17:78,852,564...78,882,573
JBrowse link
G Elk1 ELK1, member of ETS oncogene family multiple interactions ISO pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]; pyrazolanthrone inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of ELK1 protein] CTD PMID:12660819 PMID:18316600 PMID:21642427 NCBI chr  X:20,933,395...20,950,608
Ensembl chr  X:20,933,395...20,950,608
JBrowse link
G Endog endonuclease G multiple interactions ISO pyrazolanthrone inhibits the reaction [cadmium acetate affects the localization of ENDOG protein] CTD PMID:24577723 NCBI chr 2:30,171,408...30,174,069
Ensembl chr 2:30,171,493...30,174,069
JBrowse link
G Epor erythropoietin receptor multiple interactions ISO pyrazolanthrone inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA] CTD PMID:20189893 NCBI chr 9:21,958,897...21,963,576
Ensembl chr 9:21,958,897...21,963,506
JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [dihydrocapsaicin results in increased expression of ERN1 protein] CTD PMID:19139269 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852
JBrowse link
G Etfa electron transferring flavoprotein, alpha polypeptide multiple interactions ISO pyrazolanthrone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ETFA protein] CTD PMID:24394546 NCBI chr 9:55,454,436...55,512,243
Ensembl chr 9:55,454,508...55,512,243
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions ISO pyrazolanthrone inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein] CTD PMID:23255093 NCBI chr 6:47,530,274...47,595,270
Ensembl chr 6:47,530,139...47,595,341
JBrowse link
G F2 coagulation factor II multiple interactions ISO pyrazolanthrone inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein] CTD PMID:19944065 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G F3 coagulation factor III multiple interactions ISO pyrazolanthrone inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein]; pyrazolanthrone inhibits the reaction [Histamine results in increased expression of F3]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of F3 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of F3 mRNA] CTD PMID:16009787 PMID:19944065 PMID:20118172 PMID:27556861 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
G Fadd Fas (TNFRSF6)-associated via death domain multiple interactions
decreases phosphorylation
ISO pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein]; pyrazolanthrone inhibits the reaction [Paclitaxel results in increased phosphorylation of FADD protein]; pyrazolanthrone inhibits the reaction [polyphenon E results in increased phosphorylation of FADD protein]
pyrazolanthrone results in decreased phosphorylation of FADD protein
CTD PMID:16450001 PMID:21138480 PMID:23285096 NCBI chr 7:144,578,323...144,582,441
Ensembl chr 7:144,577,318...144,582,463
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) multiple interactions
increases activity
increases expression
ISO pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of FAS protein]; pyrazolanthrone promotes the reaction [FAS protein results in increased cleavage of and results in increased activity of CASP3 protein]; pyrazolanthrone promotes the reaction [FAS protein results in increased cleavage of and results in increased activity of CASP8 protein]
pyrazolanthrone results in increased activity of FAS protein
pyrazolanthrone results in increased expression of FAS protein
CTD PMID:16061660 PMID:16162944 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions ISO pyrazolanthrone affects the reaction [temozolomide results in increased expression of FASLG mRNA]; pyrazolanthrone inhibits the reaction [[sorafenib co-treated with Vitamin K 1] results in increased expression of FASLG protein]; pyrazolanthrone inhibits the reaction [Nimustine results in increased expression of FASLG mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of FASLG protein] CTD PMID:20301194 PMID:21165570 PMID:26418950 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions EXP pyrazolanthrone inhibits the reaction [Indican results in increased expression of FBXO32 protein] CTD PMID:30849338 NCBI chr15:58,175,879...58,214,892
Ensembl chr15:58,175,879...58,214,932
JBrowse link
G Fem1b fem 1 homolog b multiple interactions EXP pyrazolanthrone promotes the reaction [Ozone results in increased expression of FEM1B mRNA] CTD PMID:17460151 NCBI chr 9:62,791,824...62,811,648
Ensembl chr 9:62,791,821...62,811,934
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [FGF1 protein results in increased expression of SPP1 mRNA] CTD PMID:15121739 NCBI chr18:38,838,672...38,929,470
Ensembl chr18:38,838,673...38,929,472
JBrowse link
G Fgf15 fibroblast growth factor 15 multiple interactions ISO pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of CYP17A1 mRNA]; pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of PON1 mRNA] CTD PMID:16269825 NCBI chr 7:144,896,532...144,900,953
Ensembl chr 7:144,896,531...144,900,953
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of FGF2 mRNA]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]
pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased secretion of FGF2 protein]
pyrazolanthrone inhibits the reaction [FGF2 protein results in increased secretion of TNFRSF11B protein]
CTD PMID:12832416 PMID:19176594 PMID:25290095 PMID:26800359 PMID:28087833 NCBI chr 3:37,348,477...37,410,106
Ensembl chr 3:37,348,346...37,410,108
JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of FAS protein]; pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of SCD protein]; pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of SREBF1 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of FGF7 protein] CTD PMID:15677771 PMID:16162944 NCBI chr 2:126,034,658...126,091,185
Ensembl chr 2:126,034,658...126,091,185
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of FN1 protein]]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased expression of FN1 protein] CTD PMID:31447676 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with pyrazolanthrone] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein]; pyrazolanthrone inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased phosphorylation of FOS protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of FOS protein]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of FOS protein]
pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased expression of and results in increased phosphorylation of FOS protein]
CTD PMID:22020770 PMID:24469321 PMID:24967690 PMID:28087833 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Fosl1 fos-like antigen 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of FOSL1 mRNA]; pyrazolanthrone inhibits the reaction [Vehicle Emissions results in increased expression of FOSL1 mRNA] CTD PMID:14565943 NCBI chr19:5,447,698...5,455,938
Ensembl chr19:5,447,547...5,455,946
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein] CTD PMID:26385185 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Ethanol results in increased phosphorylation of FOXO3 protein]; pyrazolanthrone inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of FOXO3 protein] CTD PMID:26470730 NCBI chr10:42,181,845...42,276,695
Ensembl chr10:42,181,841...42,276,755
JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions ISO pyrazolanthrone inhibits the reaction [FSHB protein results in increased abundance of Estradiol]; pyrazolanthrone inhibits the reaction [FSHB protein results in increased abundance of Progesterone] CTD PMID:22067323 NCBI chr 2:107,055,986...107,059,651
Ensembl chr 2:107,056,140...107,059,656
JBrowse link
G Gabpa GA repeat binding protein, alpha multiple interactions ISO pyrazolanthrone inhibits the reaction [Gallic Acid results in increased expression of GABPA protein] CTD PMID:16308312 NCBI chr16:84,834,891...84,863,783
Ensembl chr16:84,834,925...84,863,779
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of GADD45A protein]; troglitazone inhibits the reaction [pyrazolanthrone results in increased expression of GADD45A mRNA]; troglitazone inhibits the reaction [pyrazolanthrone results in increased expression of GADD45A protein]
pyrazolanthrone inhibits the reaction [Excitatory Amino Acid Agents results in increased expression of GADD45A mRNA]
CTD PMID:15064713 PMID:20955365 PMID:25469469 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta multiple interactions ISO pyrazolanthrone inhibits the reaction [sorafenib results in increased expression of GADD45B mRNA]; pyrazolanthrone inhibits the reaction [sorafenib results in increased expression of GADD45B protein] CTD PMID:21062976 NCBI chr10:80,930,091...80,932,204
Ensembl chr10:80,930,073...80,932,204
JBrowse link
G Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of GALNT3 mRNA] CTD PMID:24614234 NCBI chr 2:66,082,766...66,125,056
Ensembl chr 2:66,082,766...66,124,994
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions EXP pyrazolanthrone inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein] CTD PMID:23940812 NCBI chr 6:88,193,891...88,207,032
Ensembl chr 6:88,193,891...88,207,032
JBrowse link
G Gch1 GTP cyclohydrolase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of GCH1 mRNA] CTD PMID:12832416 NCBI chr14:47,153,895...47,189,413
Ensembl chr14:47,153,895...47,189,413
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [[clivorine co-treated with Quercetin] results in increased expression of GCLC mRNA]; pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein]; pyrazolanthrone inhibits the reaction [Quercetin promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLC mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLC protein]
pyrazolanthrone inhibits the reaction [Ozone results in increased expression of GCLC mRNA]; pyrazolanthrone promotes the reaction [arsenite results in increased expression of GCLC mRNA]
CTD PMID:17460151 PMID:19328227 PMID:21469739 PMID:25881548 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions
decreases activity
ISO pyrazolanthrone inhibits the reaction [[Acetaminophen co-treated with Quercetin] results in increased expression of GCLM mRNA]; pyrazolanthrone inhibits the reaction [Quercetin inhibits the reaction [clivorine results in decreased expression of GCLM mRNA]]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLM mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLM protein]
pyrazolanthrone results in decreased activity of GCLM protein
CTD PMID:16972261 PMID:25881548 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO pyrazolanthrone promotes the reaction [silybin results in increased expression of GDF15 protein] CTD PMID:24440808 NCBI chr 8:70,629,393...70,632,470
Ensembl chr 8:70,629,393...70,632,456
JBrowse link
G Gh growth hormone multiple interactions ISO pyrazolanthrone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]; pyrazolanthrone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein] CTD PMID:26141394 NCBI chr11:106,300,261...106,303,703
Ensembl chr11:106,300,271...106,301,865
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Amphetamine results in increased expression of GJA1 protein]; pyrazolanthrone inhibits the reaction [Indican results in decreased expression of and affects the localization of GJA1 protein]; pyrazolanthrone inhibits the reaction [Indican results in decreased expression of GJA1 mRNA]
pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of GJA1 protein]
CTD PMID:15194466 PMID:24449132 PMID:32045570 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased activity of GLB1 protein]; pyrazolanthrone promotes the reaction [SB 203580 inhibits the reaction [Arsenic Trioxide results in increased activity of GLB1 protein]]; SB 203580 promotes the reaction [pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased activity of GLB1 protein]] CTD PMID:31734849 NCBI chr 9:114,401,078...114,474,379
Ensembl chr 9:114,401,076...114,474,898
JBrowse link
G Gp1ba glycoprotein 1b, alpha polypeptide multiple interactions ISO pyrazolanthrone promotes the reaction [THPO protein results in increased expression of GP1BA protein] CTD PMID:20523355 NCBI chr11:70,639,102...70,643,986
Ensembl chr11:70,639,122...70,642,036
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of GPT protein]
CTD PMID:20166895 PMID:26218279 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Gypa glycophorin A multiple interactions ISO pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein] CTD PMID:20523355 NCBI chr 8:80,494,045...80,510,785
Ensembl chr 8:80,493,781...80,510,542
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO pyrazolanthrone inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in increased phosphorylation of H2AX protein] CTD PMID:25619392 PMID:28993908 NCBI chr 9:44,334,715...44,336,077
Ensembl chr 9:44,334,694...44,336,077
JBrowse link
G H3f4 H3.4 histone multiple interactions ISO pyrazolanthrone inhibits the reaction [5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin results in increased phosphorylation of H3-4 protein] CTD PMID:16179969 NCBI chr11:58,961,711...58,962,273
Ensembl chr11:58,961,812...58,962,222
JBrowse link
G Hat1 histone aminotransferase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Quercetin results in increased activity of HAT1 protein] CTD PMID:21165570 NCBI chr 2:71,389,260...71,441,622
Ensembl chr 2:71,388,958...71,441,622
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO pyrazolanthrone inhibits the reaction [Oxygen deficiency promotes the reaction [HBEGF protein mutant form results in increased activity of CASP3 protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:19193634 PMID:26800359 NCBI chr18:36,504,927...36,515,805
Ensembl chr18:36,504,927...36,515,805
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of HIF1A protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein] CTD PMID:20152896 PMID:28651835 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein] CTD PMID:27616297 NCBI chr 5:149,046,702...149,053,057
Ensembl chr 5:149,046,702...149,184,489
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [[3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [butein results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [iron protoporphyrin IX results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Quercetin inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Sulindac promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]]; pyrazolanthrone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 protein]
pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Nitroprusside results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]
pyrazolanthrone results in decreased expression of HMOX1 mRNA
pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Copper results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Lead results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; pyrazolanthrone promotes the reaction [Quercetin analog results in increased expression of HMOX1 mRNA]
pyrazolanthrone results in decreased expression of HMOX1 protein
CTD PMID:12637567 PMID:16171798 PMID:16439612 PMID:16631525 PMID:18078826 PMID:18289802 PMID:18332044 PMID:18404528 PMID:18636201 PMID:21469739 PMID:22056766 PMID:23318726 PMID:23535287 PMID:23845594 PMID:24140437 PMID:24423726 PMID:25449124 PMID:25881548 PMID:26291278 PMID:26385185 PMID:26404762 PMID:26542248 PMID:27393035 PMID:27777014 PMID:28087833 PMID:29426002 PMID:31790703 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hnf4a hepatic nuclear factor 4, alpha increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of HNF4A mRNA
pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of HNF4A mRNA]
CTD PMID:19883121 NCBI chr 2:163,506,811...163,572,907
Ensembl chr 2:163,506,808...163,572,910
JBrowse link
G Hpx hemopexin multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of HPX mRNA] CTD PMID:17460151 NCBI chr 7:105,591,611...105,600,116
Ensembl chr 7:105,591,613...105,600,137
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA] CTD PMID:29567110 NCBI chr13:64,058,274...64,089,262
Ensembl chr13:64,058,266...64,089,230
JBrowse link
G Hsf1 heat shock factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased phosphorylation of HSF1 protein] CTD PMID:15978632 NCBI chr15:76,477,362...76,501,155
Ensembl chr15:76,477,422...76,501,913
JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSP90B1 mRNA] CTD PMID:20920558 NCBI chr10:86,690,841...86,705,444
Ensembl chr10:86,690,209...86,705,509
JBrowse link
G Hspa1a heat shock protein 1A multiple interactions ISO pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased expression of HSPA1A protein] CTD PMID:28087833 NCBI chr17:34,969,359...34,972,156
Ensembl chr17:34,969,190...34,972,156
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSPA5 mRNA]
pyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of HSPA5 protein]
CTD PMID:17341418 PMID:20920558 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Hspa9 heat shock protein 9 multiple interactions ISO [sodium arsenite co-treated with pyrazolanthrone] promotes the reaction [HSPA9 protein binds to TP53 protein modified form] CTD PMID:22706169 NCBI chr18:34,937,414...34,954,351
Ensembl chr18:34,937,414...34,954,357
JBrowse link
G Hspb1 heat shock protein 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HSPB1 mRNA]; pyrazolanthrone inhibits the reaction [10-nitro-oleic acid results in increased expression of HSPB1 protein]; pyrazolanthrone inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein] CTD PMID:21457723 PMID:24140437 NCBI chr 5:135,887,919...135,889,563
Ensembl chr 5:135,887,919...135,889,563
JBrowse link
G Hspb8 heat shock protein 8 multiple interactions EXP pyrazolanthrone promotes the reaction [Ozone results in increased expression of HSPB8 mRNA] CTD PMID:17460151 NCBI chr 5:116,408,491...116,422,864
Ensembl chr 5:116,408,491...116,422,864
JBrowse link
G Ibsp integrin binding sialoprotein multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Ketoglutaric Acids results in increased expression of IBSP protein] CTD PMID:31051157 NCBI chr 5:104,299,287...104,311,472
Ensembl chr 5:104,299,171...104,311,469
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of ICAM1 mRNA]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased expression of ICAM1] CTD PMID:12832416 PMID:22166487 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Ifitm6 interferon induced transmembrane protein 6 multiple interactions EXP pyrazolanthrone promotes the reaction [Ozone results in increased expression of IFITM6 mRNA] CTD PMID:17460151 NCBI chr 7:141,015,812...141,016,892
Ensembl chr 7:141,015,699...141,017,924
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; pyrazolanthrone inhibits the reaction [Eosine I Bluish results in increased expression of IFNG mRNA]
[pyrazolanthrone co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased localization of RELA protein]; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IFNG protein]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; pyrazolanthrone results in decreased susceptibility to [IFNG protein co-treated with Lipopolysaccharides]
pyrazolanthrone inhibits the reaction [[Polysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
CTD PMID:16307444 PMID:16488514 PMID:21295052 PMID:22440610 PMID:23831309 PMID:26609140 PMID:29385629 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein] CTD PMID:17458902 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions ISO pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein] CTD PMID:19616567 NCBI chr 8:22,659,205...22,706,589
Ensembl chr 8:22,659,212...22,706,589
JBrowse link
G Il10 interleukin 10 multiple interactions EXP pyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased secretion of IL10 protein] CTD PMID:28235615 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il12b interleukin 12b multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]
pyrazolanthrone promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]
CTD PMID:15778123 PMID:19101624 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Il13 interleukin 13 multiple interactions EXP pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein] CTD PMID:33075463 NCBI chr11:53,631,323...53,634,702
Ensembl chr11:53,631,324...53,634,702
JBrowse link
G Il17a interleukin 17A multiple interactions ISO pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein] CTD PMID:29385629 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496
JBrowse link
G Il18 interleukin 18 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with irinotecan] results in increased expression of and results in increased secretion of IL18 protein]
pyrazolanthrone inhibits the reaction [irinotecan results in increased expression of and results in increased secretion of IL18 protein]; pyrazolanthrone inhibits the reaction [Picryl Chloride results in increased expression of IL18 mRNA]; pyrazolanthrone inhibits the reaction [Picryl Chloride results in increased secretion of IL18 protein]
CTD PMID:20381601 PMID:26431797 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of CXCL10 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of CXCL8 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of FGF2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of GCH1 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of ICAM1 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL1A mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP1 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of PTX3 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of SERPINB2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased secretion of CXCL8 protein]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of BIRC2 mRNA]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of CCL8 mRNA]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of CXCL3 mRNA]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of JUN mRNA]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of SAA1 mRNA]
pyrazolanthrone inhibits the reaction [Soot results in increased secretion of IL1A protein]
CTD PMID:12832416 PMID:19782127 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
[Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with irinotecan] results in increased expression of and results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of IL1B protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of CYP4F11 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of F3 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of TGFB1 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of FGF7 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of TGFB1 protein]; pyrazolanthrone inhibits the reaction [IL1B results in increased expression of CXCL8 protein]; pyrazolanthrone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B protein]
pyrazolanthrone inhibits the reaction [2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]]; pyrazolanthrone inhibits the reaction [7-Ala-angiotensin (1-7) inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]]; pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased localization of RELA protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of IL1B protein]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [Soot results in increased secretion of IL1B protein]
IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; IL1B protein inhibits the reaction [pyrazolanthrone results in increased expression of THRA mRNA alternative form]; pyrazolanthrone affects the reaction [Fungal Polysaccharides results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased expression of IL1B mRNA]
CTD PMID:12832416 PMID:15019843 PMID:15677771 PMID:16359550 PMID:16365456 PMID:16614379 PMID:17641275 PMID:18982426 PMID:19626664 PMID:19782127 PMID:19812349 PMID:20712904 PMID:21295052 PMID:21430222 PMID:21447443 PMID:22547200 PMID:22687552 PMID:22727857 PMID:22728154 PMID:23535185 PMID:24781252 PMID:26218279 PMID:26431797 PMID:27174766 PMID:27302421 PMID:27556861 PMID:28004443 PMID:31199065 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il4 interleukin 4 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 mRNA]; pyrazolanthrone inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 protein]
pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]
CTD PMID:26003274 PMID:33075463 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il5 interleukin 5 multiple interactions EXP pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein] CTD PMID:33075463 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [7-ketocholesterol results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Acids results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Acids results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [OSM protein results in increased expression of and results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [polyhexamethyleneguanidine results in increased expression of IL6 mRNA]; pyrazolanthrone promotes the reaction [cadmium acetate results in increased secretion of IL6 protein]
[pyrazolanthrone co-treated with Acrylamide] results in decreased expression of IL6 mRNA; pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Soot results in increased secretion of IL6 protein]
pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of IL6 mRNA]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of IL6 protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased expression of IL6 mRNA]; pyrazolanthrone promotes the reaction [Ozone results in increased expression of IL6 mRNA]
CTD PMID:12832416 PMID:17460151 PMID:18515973 PMID:19074641 PMID:19101624 PMID:19782127 PMID:20712904 PMID:21548952 PMID:22488045 PMID:22727857 PMID:22728154 PMID:23535185 PMID:24631921 PMID:25047101 PMID:25677194 PMID:26862037 PMID:27427241 PMID:28087833 PMID:28235615 PMID:28474156 PMID:29385629 PMID:29426002 PMID:29906494 PMID:30078834 PMID:30259999 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ins2 insulin II multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]]
pyrazolanthrone inhibits the reaction [GW8510 results in increased expression of INS2 mRNA]
pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK1 protein]]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK3 protein]]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased uptake of Glucose]]
CTD PMID:17728140 PMID:22242153 PMID:24349194 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Insr insulin receptor multiple interactions ISO pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]]; pyrazolanthrone inhibits the reaction [bisphenol A results in decreased expression of INSR protein modified form]
pyrazolanthrone inhibits the reaction [oleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein]
CTD PMID:19345745 PMID:24349194 PMID:29793316 NCBI chr 8:3,150,922...3,279,649
Ensembl chr 8:3,122,061...3,279,617
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]]
pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form]
CTD PMID:17728140 PMID:29793316 NCBI chr 1:82,233,105...82,291,439
Ensembl chr 1:82,233,112...82,235,933
Ensembl chr 1:82,233,112...82,235,933
JBrowse link
G Itga2b integrin alpha 2b multiple interactions ISO pyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGA2B protein] CTD PMID:20523355 NCBI chr11:102,453,297...102,469,883
Ensembl chr11:102,453,297...102,470,122
JBrowse link
G Itgam integrin alpha M multiple interactions ISO pyrazolanthrone promotes the reaction [arsenic disulfide analog results in increased expression of ITGAM mRNA]; pyrazolanthrone promotes the reaction [arsenic disulfide analog results in increased expression of ITGAM protein] CTD PMID:18778786 NCBI chr 7:128,062,640...128,118,491
Ensembl chr 7:128,062,640...128,118,491
JBrowse link
G Itgb3 integrin beta 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]; pyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGB3 protein] CTD PMID:20523355 NCBI chr11:104,608,000...104,670,476
Ensembl chr11:104,608,000...104,670,476
JBrowse link
G Jag1 jagged 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of JAG1 mRNA] CTD PMID:21843347 NCBI chr 2:137,081,451...137,116,520
Ensembl chr 2:137,081,456...137,116,644
JBrowse link
G Jun jun proto-oncogene multiple interactions
decreases activity
decreases phosphorylation
increases degradation
decreases expression
ISO
EXP
[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with pyrazolanthrone] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein]; [pyrazolanthrone results in decreased phosphorylation of JUN protein] inhibits the reaction [JUN protein binds to TOP1 protein]; [U 0126 co-treated with pyrazolanthrone] inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of JUN protein modified form]; pyrazolanthrone inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [8-bromo-7-methoxychrysin results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [[Disulfiram co-treated with Copper co-treated with Doxorubicin] results in increased phosphorylation of and results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [[Ethacrynic Acid co-treated with Arsenic Trioxide] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [[Quercetin co-treated with mibolerone] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [[Sorafenib co-treated with Vitamin K 1] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [Bortezomib results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Chloramphenicol results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cisplatin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Estradiol results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Fenretinide results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Leflunomide results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Methyl Methanesulfonate results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [Quercetin affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [Simvastatin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in decreased expression of JUN protein modified form]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Sorafenib results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Sorafenib results in increased expression of JUN protein]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Tretinoin results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide affects the localization of JUN protein]; pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased phosphorylation of and results in increased activity of JUN protein]; pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of JUN mRNA]
pyrazolanthrone results in decreased activity of JUN protein
pyrazolanthrone results in increased degradation of JUN protein
pyrazolanthrone results in decreased expression of JUN protein
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Acrolein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Amphetamine results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Indolinone A results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased activity of JUN protein]; pyrazolanthrone inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; pyrazolanthrone promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]]
pyrazolanthrone inhibits the reaction [1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of and results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [monobutyl phthalate results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Ozone results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone promotes the reaction [[Cisplatin co-treated with TNF protein] results in increased phosphorylation of JUN protein]
CTD PMID:12169099 PMID:12393500 PMID:12663670 PMID:12774022 PMID:12832416 PMID:15019843 PMID:15028728 PMID:15034932 PMID:15194466 PMID:15196213 PMID:15252869 PMID:15322261 PMID:15342272 PMID:15677771 PMID:15838870 PMID:15850772 PMID:15923621 PMID:15930183 PMID:16041517 PMID:16061660 PMID:16166651 PMID:16322078 PMID:16337876 PMID:16357177 PMID:16407847 PMID:16872482 PMID:16932349 PMID:17125918 PMID:17460151 PMID:17950587 PMID:18021293 PMID:18593901 PMID:18633430 PMID:18982426 PMID:19002563 PMID:19225867 PMID:19292871 PMID:19418558 PMID:19768117 PMID:19812349 PMID:20148354 PMID:20301194 PMID:20338993 PMID:20632440 PMID:21062976 PMID:21165570 PMID:21911303 PMID:22003962 PMID:22020770 PMID:22166487 PMID:22288910 PMID:23082001 PMID:23103562 PMID:23219847 PMID:23836369 PMID:24111524 PMID:24469321 PMID:24967690 PMID:25200491 PMID:26209791 PMID:26514923 PMID:26630137 PMID:28087833 PMID:28474156 PMID:28697429 PMID:28988120 PMID:30133131 PMID:30709899 PMID:30768131 PMID:31306638 PMID:32738922 PMID:33677747 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Jund jun D proto-oncogene multiple interactions ISO pyrazolanthrone inhibits the reaction [2-tert-butylhydroquinone results in increased phosphorylation of JUND protein] CTD PMID:24830941 NCBI chr 8:70,697,739...70,700,616
Ensembl chr 8:70,698,949...70,700,616
JBrowse link
G Kcne4 potassium voltage-gated channel, Isk-related subfamily, gene 4 multiple interactions EXP pyrazolanthrone promotes the reaction [Ozone results in increased expression of KCNE4 mRNA] CTD PMID:17460151 NCBI chr 1:78,816,911...78,820,032
Ensembl chr 1:78,816,758...78,820,028
JBrowse link
G Klf5 Kruppel-like factor 5 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of KLF5 mRNA] CTD PMID:17460151 NCBI chr14:99,298,691...99,313,412
Ensembl chr14:99,298,691...99,315,036
JBrowse link
G Klf6 Kruppel-like factor 6 decreases expression
multiple interactions
ISO pyrazolanthrone results in decreased expression of KLF6 mRNA
Arachidonic Acid inhibits the reaction [pyrazolanthrone results in decreased expression of KLF6 mRNA]; pyrazolanthrone inhibits the reaction [Arachidonic Acid promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]]; pyrazolanthrone inhibits the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]
CTD PMID:22486562 NCBI chr13:5,861,489...5,870,393
Ensembl chr13:5,861,482...5,870,394
JBrowse link
G Klhl2 kelch-like 2, Mayven multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of KLHL2 mRNA] CTD PMID:17460151 NCBI chr 8:64,739,673...64,850,169
Ensembl chr 8:64,739,675...64,850,017
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of LDLR mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of LDLR protein] CTD PMID:22388943 NCBI chr 9:21,723,576...21,749,919
Ensembl chr 9:21,723,483...21,749,919
JBrowse link
G Lep leptin multiple interactions ISO pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lepr leptin receptor affects response to substance EXP LEPR protein affects the susceptibility to pyrazolanthrone CTD PMID:22933112 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Lpl lipoprotein lipase increases expression
multiple interactions
EXP pyrazolanthrone results in increased expression of LPL mRNA
pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of LPL mRNA]
CTD PMID:21873422 NCBI chr 8:68,880,555...68,906,932
Ensembl chr 8:68,880,491...68,907,448
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [MAP3K1 protein results in increased expression of ABCB1 mRNA] CTD PMID:15604272 NCBI chr13:111,746,428...111,818,269
Ensembl chr13:111,746,428...111,808,993
JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of MAP3K6 mRNA] CTD PMID:17460151 NCBI chr 4:133,237,979...133,252,929
Ensembl chr 4:133,240,818...133,252,929
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK1 protein]]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK1 protein]
pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK1 protein]
[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone promotes the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein]
CTD PMID:15342272 PMID:17458902 PMID:19135517 PMID:21933187 PMID:22727857 PMID:24349194 PMID:26136938 PMID:26359795 PMID:26609140 PMID:28087833 PMID:30317802 PMID:33771252 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions
decreases phosphorylation
increases expression
ISO pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased phosphorylation of MAPK14 protein]
pyrazolanthrone results in decreased phosphorylation of MAPK14 protein
pyrazolanthrone results in increased expression of MAPK14 protein
CTD PMID:15964311 PMID:16046226 NCBI chr17:28,691,342...28,748,405
Ensembl chr17:28,691,329...28,748,406
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of MAPK3 protein]]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein]
[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK3 protein]
[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone promotes the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein]
CTD PMID:15342272 PMID:17458902 PMID:19135517 PMID:21933187 PMID:22727857 PMID:24349194 PMID:26136938 PMID:26359795 PMID:26609140 PMID:28087833 PMID:30317802 PMID:30580027 PMID:33771252 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases expression
decreases phosphorylation
decreases activity
ISO
EXP
pyrazolanthrone inhibits the reaction [5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [8-bromo-7-methoxychrysin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased expression of MAPK8 protein]; pyrazolanthrone inhibits the reaction [benzyl isothiocyanate results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [dracorhodin analog results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [glycine-extended gastrin 17 results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [LY 293111 results in increased expression of MAPK8 protein modified form]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Plant Extracts results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [polyphyllin I results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Selenite results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK8 protein]]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of MAPK8 protein]
pyrazolanthrone results in increased expression of MAPK8 protein
pyrazolanthrone results in decreased phosphorylation of MAPK8 protein
pyrazolanthrone inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of MAPK8 mRNA]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Paroxetine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sertraline results in increased phosphorylation of and results in increased activity of MAPK8 protein]
[pyrazolanthrone co-treated with 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride] inhibits the reaction [Folic Acid results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone affects the reaction [TALDO1 gene mutant form promotes the reaction [Acetaminophen results in increased activity of and results in increased phosphorylation of MAPK8 protein]]; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased activity of and results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased phosphorylation of and affects the activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Folic Acid results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Tretinoin results in increased activity of MAPK8 protein]; pyrazolanthrone results in decreased phosphorylation of and results in decreased activity of MAPK8 protein
pyrazolanthrone results in decreased activity of MAPK8 protein
CTD PMID:12534346 PMID:14610070 PMID:15322261 PMID:15767555 PMID:15831436 PMID:15964311 PMID:16041517 PMID:16046226 PMID:16151469 PMID:16374168 PMID:16442704 PMID:16648635 PMID:16687388 PMID:16777994 PMID:16864444 PMID:17185352 PMID:17651887 PMID:17728140 PMID:18347188 PMID:18412143 PMID:18495191 PMID:18506790 PMID:18728404 PMID:18840457 PMID:19038359 PMID:19135517 PMID:19436114 PMID:20206247 PMID:20534739 PMID:20632440 PMID:20678559 PMID:21112663 PMID:21219922 PMID:21626648 PMID:21843586 PMID:21933187 PMID:22085843 PMID:22696236 PMID:24833599 PMID:25531190 PMID:26385185 PMID:27174766 PMID:28474156 PMID:29906494 PMID:30259999 PMID:30768131 PMID:31176653 PMID:31348969 PMID:31421117 PMID:31447676 PMID:31587482 PMID:31734849 PMID:32574669 PMID:33075463 PMID:33771252 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
decreases phosphorylation
decreases activity
ISO
EXP
pyrazolanthrone inhibits the reaction [5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [LY 293111 results in increased expression of MAPK9 protein modified form]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Plant Extracts results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [polyphyllin I results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Selenite results in increased phosphorylation of and results in increased activity of MAPK9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of MAPK9 protein]
pyrazolanthrone results in decreased phosphorylation of MAPK9 protein
pyrazolanthrone inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased phosphorylation of MAPK9 protein]
pyrazolanthrone inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK9 protein]
pyrazolanthrone results in decreased activity of MAPK9 protein
CTD PMID:12534346 PMID:15322261 PMID:15831436 PMID:16151469 PMID:16687388 PMID:16777994 PMID:17651887 PMID:18347188 PMID:18412143 PMID:18728404 PMID:18840457 PMID:19038359 PMID:19135517 PMID:20206247 PMID:20678559 PMID:21843586 PMID:22085843 PMID:22696236 PMID:25531190 PMID:26385185 PMID:27174766 PMID:28474156 PMID:29906494 PMID:31348969 PMID:31421117 PMID:33075463 NCBI chr11:49,846,728...49,886,421
Ensembl chr11:49,846,751...49,886,421
JBrowse link
G Mapkapk2 MAP kinase-activated protein kinase 2 decreases activity ISO pyrazolanthrone results in decreased activity of MAPKAPK2 protein CTD PMID:15196213 NCBI chr 1:131,053,700...131,097,871
Ensembl chr 1:131,053,700...131,097,826
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; pyrazolanthrone promotes the reaction [usnic acid results in decreased expression of MCL1 protein] CTD PMID:23082001 PMID:25078063 NCBI chr 3:95,656,944...95,663,179
Ensembl chr 3:95,658,788...95,663,176
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [trichostatin A results in decreased expression of MCM2 protein] CTD PMID:23770000 NCBI chr 6:88,883,474...88,898,780
Ensembl chr 6:88,883,474...88,898,780
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) multiple interactions ISO pyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of PRKCD protein] CTD PMID:16872482 NCBI chr10:75,859,353...75,860,277
Ensembl chr10:75,859,353...75,860,240
JBrowse link
G Mir21a microRNA 21a multiple interactions
affects expression
ISO pyrazolanthrone affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA]
pyrazolanthrone affects the expression of MIR21 mRNA
CTD PMID:24434654 NCBI chr11:86,584,067...86,584,158
Ensembl chr11:86,584,067...86,584,158
JBrowse link
G Mir328 microRNA 328 increases expression ISO pyrazolanthrone results in increased expression of MIR328 mRNA CTD PMID:25605016 NCBI chr 8:105,308,364...105,308,460
Ensembl chr 8:105,308,364...105,308,460
JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA] CTD PMID:16359550 NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO pyrazolanthrone inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]; pyrazolanthrone inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein] CTD PMID:16948116 PMID:20004183 PMID:20338993 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) multiple interactions ISO pyrazolanthrone inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA] CTD PMID:19661247 NCBI chr14:54,431,598...54,442,456
Ensembl chr14:54,431,612...54,445,364
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) multiple interactions ISO pyrazolanthrone inhibits the reaction [2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of and results in increased activity of MMP1 protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP1 mRNA]; pyrazolanthrone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of MMP1 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP1 protein] CTD PMID:12832416 PMID:20004183 PMID:24469321 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP2 protein]; pyrazolanthrone inhibits the reaction [resveratrol results in decreased expression of MMP2]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; pyrazolanthrone promotes the reaction [resveratrol results in decreased expression of and results in decreased activity of MMP2 protein]
pyrazolanthrone inhibits the reaction [Particulate Matter results in increased methylation of MMP2 promoter]
pyrazolanthrone inhibits the reaction [Doxorubicin results in increased activity of MMP2 protein]; pyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of MMP2 mRNA]
CTD PMID:16213474 PMID:20599481 PMID:22355787 PMID:24841706 PMID:25605016 PMID:27060453 PMID:28722351 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [Citrinin results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein] CTD PMID:12832416 PMID:16778083 PMID:19361540 PMID:20004183 NCBI chr 9:7,445,822...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity
ISO [kahweol acetate co-treated with pyrazolanthrone] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of and results in increased activity of MMP9 protein]; pyrazolanthrone affects the reaction [TNF protein results in increased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [hydroquinone results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in decreased expression of MMP9]; pyrazolanthrone inhibits the reaction [tetrabromobisphenol A results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of and results in increased activity of MMP9 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of and results in increased activity of MMP9 protein]; pyrazolanthrone promotes the reaction [ovatodiolide results in decreased activity of MMP9 protein]
pyrazolanthrone inhibits the reaction [RELA protein binds to MMP9 promoter]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; pyrazolanthrone promotes the reaction [Doxorubicin results in increased expression of MMP9 mRNA]
pyrazolanthrone results in decreased activity of MMP9 protein
CTD PMID:16213474 PMID:19447859 PMID:20152819 PMID:21354279 PMID:22033475 PMID:22705379 PMID:22926441 PMID:23774252 PMID:24841706 PMID:25200491 PMID:26514923 PMID:26807887 PMID:27060453 PMID:28722351 PMID:30133131 PMID:30590137 PMID:30766661 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of MT1 mRNA] CTD PMID:17460151 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327
JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric multiple interactions ISO pyrazolanthrone inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]; pyrazolanthrone inhibits the reaction [polyhexamethyleneguanidine results in increased expression of MUC5AC mRNA]; pyrazolanthrone inhibits the reaction [polyhexamethyleneguanidine results in increased expression of MUC5AC protein]; pyrazolanthrone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA]; pyrazolanthrone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC protein]; pyrazolanthrone promotes the reaction [[Smoke results in increased abundance of Particulate Matter] which results in increased expression of MUC5AC mRNA] CTD PMID:21544845 PMID:22766066 PMID:25177032 PMID:30935901 PMID:31944254 NCBI chr 7:141,788,958...141,819,227
Ensembl chr 7:141,788,972...141,819,231
JBrowse link
G Myc myelocytomatosis oncogene increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of MYC protein
pyrazolanthrone inhibits the reaction [Diethylnitrosamine results in increased expression of MYC protein]
MYC affects the reaction [pyrazolanthrone results in increased expression of BAX protein]; MYC affects the reaction [pyrazolanthrone results in increased expression of MYC protein]; MYC affects the reaction [pyrazolanthrone results in increased expression of TP53 protein]
CTD PMID:15034932 PMID:19418558 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Myh2 myosin, heavy polypeptide 2, skeletal muscle, adult multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of MYH2 mRNA] CTD PMID:17460151 NCBI chr11:67,171,027...67,197,517
Ensembl chr11:67,171,027...67,197,517
JBrowse link
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha multiple interactions EXP pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of MYH6 mRNA] CTD PMID:21873422 NCBI chr14:54,941,921...54,968,017
Ensembl chr14:54,941,921...54,966,927
JBrowse link
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta multiple interactions EXP pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of MYH7 mRNA] CTD PMID:21873422 NCBI chr14:54,970,684...54,994,626
Ensembl chr14:54,970,684...54,994,626
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Glucose results in increased expression of NCF1 protein] CTD PMID:22245600 NCBI chr 5:134,220,053...134,229,628
Ensembl chr 5:134,220,053...134,229,625
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
decreases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [3-O-caffeoyl-1-methylquinic acid affects the localization of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [[3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]
pyrazolanthrone inhibits the reaction [[Plant Extracts co-treated with Ethanol] results in increased expression of and affects the localization of NFE2L2 protein]
pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]]; pyrazolanthrone inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [diphenylarsinic acid results in increased expression of NFE2L2 protein]
pyrazolanthrone results in decreased expression of NFE2L2 protein
CTD PMID:16631525 PMID:17640564 PMID:23535287 PMID:25449124 PMID:25649257 PMID:28087833 PMID:29426002 PMID:30928397 PMID:31790703 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO
EXP
pyrazolanthrone affects the reaction [sodium arsenite affects the expression of NFKB1 protein]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]
pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of NFKB1 mRNA]
pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased phosphorylation of NFKB1 protein]
CTD PMID:18507870 PMID:22547200 PMID:29528074 PMID:30259999 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO pyrazolanthrone inhibits the reaction [1,2,5,8-tetrahydroxy anthraquinone results in increased expression of NFKBIA protein]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]
pyrazolanthrone inhibits the reaction [Glucose results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD PMID:18507870 PMID:22245600 PMID:33030807 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Ngf nerve growth factor multiple interactions ISO pyrazolanthrone inhibits the reaction [Edaravone results in increased expression of NGF mRNA]; pyrazolanthrone inhibits the reaction [Edaravone results in increased expression of NGF protein]
pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF mRNA]; pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF protein]
CTD PMID:17651887 PMID:19954754 NCBI chr 3:102,469,919...102,521,013
Ensembl chr 3:102,469,919...102,521,013
JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) multiple interactions ISO pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]; pyrazolanthrone inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein] CTD PMID:17651887 NCBI chr11:95,568,818...95,587,698
Ensembl chr11:95,568,818...95,587,735
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [APP protein results in increased expression of NLRP3 protein]
pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA]
CTD PMID:28004443 PMID:30259999 NCBI chr11:59,541,569...59,566,955
Ensembl chr11:59,541,568...59,566,956
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]
pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Humic Substances results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Humic Substances results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of NOS2 mRNA]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [Phosgene results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]
CTD PMID:16417967 PMID:16488514 PMID:17570326 PMID:18507870 PMID:19376148 PMID:19497418 PMID:20004183 PMID:20423716 PMID:20712904 PMID:21818760 PMID:22227475 PMID:22547200 PMID:23268108 PMID:23500011 PMID:23727179 PMID:23735482 PMID:24239652 PMID:26218279 PMID:30259999 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] CTD PMID:16213474 NCBI chr  X:134,086,421...134,137,711
Ensembl chr  X:134,086,421...134,221,956
JBrowse link
G Nppb natriuretic peptide type B multiple interactions EXP pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of NPPB mRNA] CTD PMID:21873422 NCBI chr 4:147,985,786...147,987,205
Ensembl chr 4:147,985,788...147,987,205
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Copper results in increased expression of NQO1 mRNA]; pyrazolanthrone inhibits the reaction [Copper results in increased expression of NQO1 protein]; pyrazolanthrone inhibits the reaction [Lead results in increased expression of NQO1 mRNA]; pyrazolanthrone inhibits the reaction [Lead results in increased expression of NQO1 protein]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of NQO1 protein]
pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of NQO1 mRNA]
CTD PMID:18752316 PMID:29426002 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA] CTD PMID:19593819 NCBI chr 4:133,553,376...133,556,686
Ensembl chr 4:133,553,376...133,556,536
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO pyrazolanthrone results in increased expression of NR1H3 mRNA CTD PMID:19883121 NCBI chr 2:91,184,061...91,202,829
Ensembl chr 2:91,184,061...91,202,834
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP pyrazolanthrone inhibits the reaction [NR1H4 gene mutant form promotes the reaction [Taurocholic Acid results in increased expression of CCL2 mRNA]] CTD PMID:28505368 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Valproic Acid inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]] CTD PMID:15249158 NCBI chr18:39,410,545...39,519,421
Ensembl chr18:39,410,545...39,519,421
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions EXP pyrazolanthrone promotes the reaction [Ozone results in increased expression of NR4A1 mRNA] CTD PMID:17460151 NCBI chr15:101,253,902...101,274,795
Ensembl chr15:101,254,269...101,274,795
JBrowse link
G Optn optineurin multiple interactions ISO pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of OPTN protein] CTD PMID:28776281 NCBI chr 2:5,020,521...5,064,399
Ensembl chr 2:5,020,642...5,064,051
JBrowse link
G Osm oncostatin M multiple interactions ISO pyrazolanthrone inhibits the reaction [OSM protein results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:21548952 NCBI chr11:4,236,785...4,241,026
Ensembl chr11:4,236,420...4,241,026
JBrowse link
G Ostm1 osteopetrosis associated transmembrane protein 1 multiple interactions EXP [crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA] CTD PMID:30580027 NCBI chr10:42,678,916...42,702,462
Ensembl chr10:42,583,822...42,702,459
JBrowse link
G Pappa pregnancy-associated plasma protein A multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA] CTD PMID:24781252 NCBI chr 4:65,124,174...65,357,509
Ensembl chr 4:65,124,174...65,357,509
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [coronarin D results in increased expression of PARP1 protein modified form]; pyrazolanthrone inhibits the reaction [dehydroxymethylepoxyquinomicin results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Docetaxel results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [LY 293111 results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [morusin results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [polyphyllin I results in increased expression of PARP1 protein modified form]; pyrazolanthrone inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]; pyrazolanthrone promotes the reaction [dihydromyricetin results in increased cleavage of PARP1 protein]; pyrazolanthrone results in increased susceptibility to [[TNFSF10 protein co-treated with kahweol acetate] results in increased cleavage of PARP1 protein]
pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of PARP1 protein]; pyrazolanthrone inhibits the reaction [bakuchiol results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [cadmium acetate results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein]
pyrazolanthrone inhibits the reaction [3-dinitrobenzene results in increased cleavage of PARP1 protein]
CTD PMID:14724571 PMID:15501958 PMID:16151469 PMID:16328441 PMID:16407847 PMID:17292878 PMID:18281123 PMID:19477251 PMID:19777565 PMID:20403343 PMID:21165570 PMID:21843586 PMID:23082001 PMID:23405080 PMID:24036456 PMID:24577723 PMID:25043952 PMID:25446857 PMID:25939952 PMID:27539140 PMID:28087840 PMID:28283887 PMID:29968959 PMID:30871965 PMID:31421117 PMID:33035517 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [Diethylnitrosamine results in increased expression of PCNA protein]
pyrazolanthrone results in decreased expression of PCNA protein
CTD PMID:18593901 PMID:19418558 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide decreases expression ISO pyrazolanthrone results in decreased expression of PDGFRB mRNA; pyrazolanthrone results in decreased expression of PDGFRB protein CTD PMID:18332871 NCBI chr18:61,045,127...61,085,067
Ensembl chr18:61,045,150...61,085,061
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of PDK4 mRNA] CTD PMID:17460151 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
JBrowse link
G Plat plasminogen activator, tissue multiple interactions ISO pyrazolanthrone inhibits the reaction [Valproic Acid results in increased activity of PLAT protein] CTD PMID:23378038 NCBI chr 8:22,757,722...22,782,848
Ensembl chr 8:22,757,727...22,782,844
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO pyrazolanthrone inhibits the reaction [TNF protein results in increased activity of PLAU protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of PLAU protein]; pyrazolanthrone promotes the reaction [resveratrol results in decreased expression of PLAU protein] CTD PMID:19874453 PMID:23437203 NCBI chr14:20,836,662...20,843,388
Ensembl chr14:20,836,660...20,843,385
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO pyrazolanthrone inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA] CTD PMID:22261521 NCBI chr 7:24,460,937...24,475,970
Ensembl chr 7:24,462,484...24,475,968
JBrowse link
G Plcb1 phospholipase C, beta 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA] CTD PMID:19225867 NCBI chr 2:134,786,164...135,475,258
Ensembl chr 2:134,786,067...135,475,258
JBrowse link
G Plcb3 phospholipase C, beta 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA] CTD PMID:19225867 NCBI chr19:6,953,708...6,975,006
Ensembl chr19:6,952,325...6,976,470
JBrowse link
G Plcd1 phospholipase C, delta 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA] CTD PMID:19225867 NCBI chr 9:119,071,527...119,093,502
Ensembl chr 9:119,071,527...119,093,502
JBrowse link
G Plin3 perilipin 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [CpG ODN 1826 results in increased expression of PLIN3 mRNA] CTD PMID:20628022 NCBI chr17:56,278,962...56,290,511
Ensembl chr17:56,277,476...56,292,873
JBrowse link
G Plxna2 plexin A2 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of PLXNA2 mRNA] CTD PMID:17460151 NCBI chr 1:194,619,791...194,816,869
Ensembl chr 1:194,618,218...194,816,869
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Chenodeoxycholic Acid results in decreased expression of PON1 mRNA]; pyrazolanthrone inhibits the reaction [FGF19 protein results in decreased expression of PON1 mRNA]; pyrazolanthrone inhibits the reaction [GW 4064 results in decreased expression of PON1 mRNA] CTD PMID:16269825 NCBI chr 6:5,168,090...5,193,987
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Pon2 paraoxonase 2 decreases expression EXP pyrazolanthrone results in decreased expression of PON2 protein CTD PMID:15544923 NCBI chr 6:5,264,620...5,298,345
Ensembl chr 6:5,264,147...5,298,455
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of PPARA mRNA]
pyrazolanthrone results in increased expression of PPARA mRNA
pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARA mRNA]
CTD PMID:19883121 PMID:21873422 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ppard peroxisome proliferator activator receptor delta multiple interactions ISO pyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of PPARD protein] CTD PMID:17341418 NCBI chr17:28,232,754...28,301,469
Ensembl chr17:28,232,700...28,301,474
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression
multiple interactions
ISO pyrazolanthrone results in increased expression of PPARG mRNA; pyrazolanthrone results in increased expression of PPARG protein
pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of PPARG protein]
CTD PMID:17372590 PMID:28283887 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression
multiple interactions
EXP pyrazolanthrone results in increased expression of PPARGC1A mRNA
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride promotes the reaction [pyrazolanthrone inhibits the reaction [Folic Acid results in decreased expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]; pyrazolanthrone inhibits the reaction [Folic Acid results in decreased expression of PPARGC1A protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARGC1A mRNA]; pyrazolanthrone promotes the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in decreased expression of PPARGC1A protein]]
CTD PMID:21873422 PMID:31447676 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Prf1 perforin 1 (pore forming protein) multiple interactions ISO pyrazolanthrone inhibits the reaction [resveratrol results in increased expression of PRF1 protein] CTD PMID:20082299 NCBI chr10:61,297,751...61,304,684
Ensembl chr10:61,297,833...61,304,680
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO pyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of PRKCD protein] CTD PMID:16872482 NCBI chr14:30,595,353...30,626,414
Ensembl chr14:30,595,354...30,626,210
JBrowse link
G Procr protein C receptor, endothelial multiple interactions EXP pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased cleavage of PROCR protein] CTD PMID:24632454 NCBI chr 2:155,751,125...155,755,478
Ensembl chr 2:155,751,117...155,755,471
JBrowse link
G Psat1 phosphoserine aminotransferase 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of PSAT1 mRNA] CTD PMID:17460151 NCBI chr19:15,905,123...15,925,059
Ensembl chr19:15,904,678...15,947,337
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased expression of PTEN protein] CTD PMID:20534739 NCBI chr19:32,757,577...32,826,160
Ensembl chr19:32,757,497...32,826,160
JBrowse link
G Ptgds prostaglandin D2 synthase (brain) multiple interactions EXP pyrazolanthrone affects the reaction [2-chloroethyl ethyl sulfide results in increased expression of PTGDS mRNA] CTD PMID:20382172 NCBI chr 2:25,466,709...25,470,110
Ensembl chr 2:25,466,709...25,470,046
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; pyrazolanthrone inhibits the reaction [Aflatoxin B1 results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; pyrazolanthrone promotes the reaction [Sodium Fluoride results in increased expression of PTGS2 protein]; pyrazolanthrone promotes the reaction [U 0126 inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]]
pyrazolanthrone inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]
pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; pyrazolanthrone inhibits the reaction [arsenite results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Endosulfan results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Humic Substances results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Humic Substances results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [Phosgene results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased expression of PTGS2 protein]; pyrazolanthrone promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Sodium Selenite inhibits the reaction [pyrazolanthrone promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
CTD PMID:12832416 PMID:17084486 PMID:18481333 PMID:18507870 PMID:18596194 PMID:18840457 PMID:19376214 PMID:19808956 PMID:20004183 PMID:21262218 PMID:21818760 PMID:21911040 PMID:22288910 PMID:22547200 PMID:22728154 PMID:22767315 PMID:23268108 PMID:23376440 PMID:23416140 PMID:23500011 PMID:23727179 PMID:23735482 PMID:24239652 PMID:24967690 PMID:25199686 PMID:25888188 PMID:26218279 PMID:27818125 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ptx3 pentraxin related gene multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of PTX3 mRNA] CTD PMID:12832416 NCBI chr 3:66,219,887...66,225,806
Ensembl chr 3:66,219,910...66,225,805
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO pyrazolanthrone inhibits the reaction [Prodigiosin results in decreased expression of RAD51 mRNA] CTD PMID:22579953 NCBI chr 2:119,112,814...119,136,073
Ensembl chr 2:119,112,793...119,147,445
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of RAPGEF4 mRNA] CTD PMID:17460151 NCBI chr 2:71,981,215...72,257,474
Ensembl chr 2:71,981,240...72,257,474
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of RB1 mRNA]; pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of RB1 protein] CTD PMID:14729647 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822
JBrowse link
G Reg3g regenerating islet-derived 3 gamma multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of REG3G mRNA] CTD PMID:17460151 NCBI chr 6:78,466,269...78,468,874
Ensembl chr 6:78,466,269...78,468,872
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
decreases expression
ISO
EXP
pyrazolanthrone affects the reaction [sodium arsenite affects the expression of RELA protein]; pyrazolanthrone inhibits the reaction [Acids results in increased activity of RELA protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in decreased activity of RELA protein]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Homocysteine results in increased activity of RELA protein]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Paraquat results in increased activity of RELA protein]; pyrazolanthrone inhibits the reaction [sodium arsenite affects the localization of RELA protein]; pyrazolanthrone inhibits the reaction [Sodium Fluoride affects the localization of RELA protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of RELA protein]
pyrazolanthrone results in decreased expression of RELA protein
pyrazolanthrone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased localization of RELA protein]; pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of RELA protein]; pyrazolanthrone inhibits the reaction [RELA protein binds to MMP9 promoter]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of RELA protein]; pyrazolanthrone inhibits the reaction [TNF protein affects the localization of RELA protein]
pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Cisplatin inhibits the reaction [TNF protein affects the localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Cyclosporine affects the localization of RELA protein]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of RELA protein]]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of RELA protein]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased phosphorylation of RELA protein]
CTD PMID:18507870 PMID:19074641 PMID:19616567 PMID:20534739 PMID:21295052 PMID:22547200 PMID:22706169 PMID:23103562 PMID:23774252 PMID:23958496 PMID:25540590 PMID:25677194 PMID:25888188 PMID:28474156 PMID:29426002 PMID:29528074 PMID:30133131 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Retnla resistin like alpha multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of RETNLA mRNA] CTD PMID:17460151 NCBI chr16:48,842,609...48,844,461
Ensembl chr16:48,842,551...48,844,461
JBrowse link
G Riox2 ribosomal oxygenase 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein] CTD PMID:24434654 NCBI chr16:59,471,753...59,492,532
Ensembl chr16:59,471,775...59,492,461
JBrowse link
G Robo1 roundabout guidance receptor 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [JZL 184 affects the localization of and affects the expression of ROBO1 protein] CTD PMID:25030704 NCBI chr16:72,027,518...73,047,491
Ensembl chr16:72,308,306...73,046,095
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions
decreases activity
EXP
ISO
pyrazolanthrone affects the reaction [flufenoxuron results in decreased phosphorylation of RPS6KB1 protein]; pyrazolanthrone inhibits the reaction [arsenite results in decreased phosphorylation of RPS6KB1 protein]; pyrazolanthrone inhibits the reaction [Ketoglutaric Acids results in increased phosphorylation of RPS6KB1 protein]
pyrazolanthrone results in decreased activity of RPS6KB1 protein
CTD PMID:12534346 PMID:20589738 PMID:31051157 PMID:33771252 NCBI chr11:86,498,869...86,544,885
Ensembl chr11:86,498,871...86,544,805
JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions ISO
EXP
[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of RUNX2 mRNA]
pyrazolanthrone inhibits the reaction [Ethanol results in increased activity of RUNX2 protein]
pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of RUNX2 protein]
CTD PMID:26136938 PMID:31306638 PMID:32198086 NCBI chr17:44,495,987...44,814,797
Ensembl chr17:44,495,987...44,814,797
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions EXP
ISO
pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of RXRA protein]
pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased phosphorylation of RXRA protein]
CTD PMID:16038797 PMID:16184197 NCBI chr 2:27,676,445...27,763,319
Ensembl chr 2:27,676,440...27,762,957
JBrowse link
G S100a4 S100 calcium binding protein A4 multiple interactions ISO pyrazolanthrone inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein] CTD PMID:16948116 NCBI chr 3:90,603,770...90,606,045
Ensembl chr 3:90,603,771...90,606,045
JBrowse link
G Saa1 serum amyloid A 1 multiple interactions ISO pyrazolanthrone promotes the reaction [IL1A protein results in increased expression of SAA1 mRNA] CTD PMID:12832416 NCBI chr 7:46,740,497...46,743,181
Ensembl chr 7:46,740,497...46,742,980
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of SCD protein] CTD PMID:16162944 NCBI chr19:44,293,676...44,306,864
Ensembl chr19:44,293,674...44,306,864
JBrowse link
G Serpina7 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 multiple interactions ISO pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of SERPINA7 protein] CTD PMID:29385629 NCBI chr  X:139,079,249...139,085,236
Ensembl chr  X:139,079,257...139,085,236
JBrowse link
G Serpinb2 serine (or cysteine) peptidase inhibitor, clade B, member 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of SERPINB2 mRNA] CTD PMID:12832416 NCBI chr 1:107,500,892...107,525,600
Ensembl chr 1:107,511,423...107,535,478
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [Catechin results in decreased expression of SERPINE1 mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in decreased expression of SERPINE1 mRNA]
pyrazolanthrone inhibits the reaction [Valproic Acid results in decreased activity of and results in decreased secretion of SERPINE1 protein]
CTD PMID:17379280 PMID:23378038 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases activity ISO pyrazolanthrone results in decreased activity of SGK1 protein CTD PMID:12534346 NCBI chr10:21,882,184...21,999,903
Ensembl chr10:21,882,184...21,999,903
JBrowse link
G Shc1 src homology 2 domain-containing transforming protein C1 multiple interactions ISO pyrazolanthrone inhibits the reaction [diallyl trisulfide results in increased phosphorylation of SHC1 protein] CTD PMID:21616139 PMID:22020565 NCBI chr 3:89,418,551...89,430,029
Ensembl chr 3:89,418,443...89,430,027
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein]
pyrazolanthrone inhibits the reaction [Silicon Dioxide promotes the reaction [Cycloheximide results in decreased expression of SIRT1 protein]]; pyrazolanthrone inhibits the reaction [Silicon Dioxide results in decreased expression of SIRT1 protein]
CTD PMID:22669716 PMID:31082419 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Rotenone results in decreased activity of SLC18A2 protein] CTD PMID:25496994 NCBI chr19:59,260,878...59,296,012
Ensembl chr19:59,260,896...59,296,012
JBrowse link
G Slc27a1 solute carrier family 27 (fatty acid transporter), member 1 multiple interactions
increases expression
EXP pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC27A1 mRNA]
pyrazolanthrone results in increased expression of SLC27A1 mRNA
CTD PMID:21873422 NCBI chr 8:71,568,728...71,587,307
Ensembl chr 8:71,568,882...71,587,302
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Diethylnitrosamine affects the phosphorylation of SMAD3 protein]
[pyrazolanthrone co-treated with 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride] inhibits the reaction [Folic Acid results in increased phosphorylation of SMAD3 protein]
CTD PMID:19418558 PMID:31447676 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994
JBrowse link
G Snai1 snail family zinc finger 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein] CTD PMID:27060453 NCBI chr 2:167,538,195...167,542,814
Ensembl chr 2:167,538,195...167,542,814
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO pyrazolanthrone inhibits the reaction [BDNF protein results in increased expression of SOD2 protein]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA] CTD PMID:12832416 PMID:22261313 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of SOX2 protein] CTD PMID:23219847 NCBI chr 3:34,649,995...34,652,461
Ensembl chr 3:34,650,405...34,652,461
JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 multiple interactions ISO pyrazolanthrone promotes the reaction [resveratrol results in increased expression of SOX9] CTD PMID:24841706 NCBI chr11:112,782,210...112,787,757
Ensembl chr11:112,782,224...112,787,760
JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein] CTD PMID:26385185 NCBI chr15:102,406,316...102,436,404
Ensembl chr15:102,406,143...102,436,404
JBrowse link
G Sp7 Sp7 transcription factor 7 multiple interactions EXP pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of SP7 protein] CTD PMID:31306638 NCBI chr15:102,356,603...102,367,035
Ensembl chr15:102,356,606...102,367,182
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [FGF1 protein results in increased expression of SPP1 mRNA]
pyrazolanthrone inhibits the reaction [Ketoglutaric Acids results in increased expression of SPP1 protein]
CTD PMID:15121739 PMID:31051157 NCBI chr 5:104,435,111...104,441,053
Ensembl chr 5:104,435,118...104,441,050
JBrowse link
G Sprr2h small proline-rich protein 2H multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of SPRR2A mRNA] CTD PMID:17460151 NCBI chr 3:92,385,685...92,387,324
Ensembl chr 3:92,385,685...92,387,324
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
increases expression
ISO
EXP
pyrazolanthrone inhibits the reaction [morusin results in decreased expression of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of SQSTM1 protein]
pyrazolanthrone inhibits the reaction [Colistin results in increased degradation of SQSTM1 protein]
pyrazolanthrone inhibits the reaction [methylmercuric chloride results in increased expression of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of SQSTM1 protein]
pyrazolanthrone results in decreased expression of SQSTM1 protein
pyrazolanthrone results in increased expression of SQSTM1 protein
CTD PMID:24833599 PMID:25881548 PMID:27393035 PMID:27667695 PMID:28842171 PMID:33035517 PMID:33684387 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of SREBF1 protein] CTD PMID:16162944 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Srebf2 sterol regulatory element binding factor 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of SREBF2 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased metabolism of and affects the localization of SREBF2 protein] CTD PMID:22388943 PMID:33677747 NCBI chr15:82,147,269...82,205,379
Ensembl chr15:82,147,181...82,205,379
JBrowse link
G Srrt serrate RNA effector molecule homolog (Arabidopsis) multiple interactions ISO pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of SRRT protein] CTD PMID:23219847 NCBI chr 5:137,295,704...137,307,716
Ensembl chr 5:137,295,704...137,307,674
JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 multiple interactions ISO pyrazolanthrone inhibits the reaction [Tretinoin results in increased expression of ST8SIA3 mRNA] CTD PMID:17069899 NCBI chr18:64,254,359...64,276,146
Ensembl chr18:64,254,359...64,279,611
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of STAR protein]
pyrazolanthrone inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of STAR protein]
CTD PMID:29567110 PMID:32199951 NCBI chr 8:25,808,474...25,815,982
Ensembl chr 8:25,806,555...25,815,982
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein] CTD PMID:26609140 NCBI chr 1:52,119,438...52,161,865
Ensembl chr 1:52,119,440...52,161,865
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
ISO pyrazolanthrone inhibits the reaction [1,2,5,8-tetrahydroxy anthraquinone results in decreased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased phosphorylation of STAT3 protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]
pyrazolanthrone results in increased phosphorylation of STAT3 protein
pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased phosphorylation of and affects the localization of STAT3 protein]
CTD PMID:19429262 PMID:22696236 PMID:24349194 PMID:27174766 PMID:30871965 PMID:33030807 NCBI chr11:100,886,806...100,939,594
Ensembl chr11:100,885,098...100,939,540
JBrowse link
G Syt11 synaptotagmin XI multiple interactions EXP pyrazolanthrone inhibits the reaction [Ozone results in increased expression of SYT11 mRNA] CTD PMID:17460151 NCBI chr 3:88,744,699...88,775,159
Ensembl chr 3:88,744,700...88,775,164
JBrowse link
G Tac1 tachykinin 1 multiple interactions ISO pyrazolanthrone promotes the reaction [GR 73632 promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:18809416 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
JBrowse link
G Taldo1 transaldolase 1 multiple interactions EXP pyrazolanthrone affects the reaction [TALDO1 gene mutant form promotes the reaction [Acetaminophen results in increased activity of and results in increased phosphorylation of MAPK8 protein]] CTD PMID:19436114 NCBI chr 7:141,392,160...141,402,976
Ensembl chr 7:141,392,199...141,402,968
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO pyrazolanthrone promotes the reaction [Paraquat results in increased expression of TARDBP protein modified form] CTD PMID:22879928 NCBI chr 4:148,612,382...148,627,084
Ensembl chr 4:148,612,382...148,627,019
JBrowse link
G Tat tyrosine aminotransferase multiple interactions ISO pyrazolanthrone inhibits the reaction [Colchicine results in decreased expression of TAT mRNA] CTD PMID:15744361 NCBI chr 8:109,986,078...109,999,804
Ensembl chr 8:109,990,437...109,999,803
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO [pyrazolanthrone co-treated with SB 203580 co-treated with U 0126] inhibits the reaction [Isothiocyanates results in increased expression of TERT mRNA] CTD PMID:23382840 NCBI chr13:73,626,911...73,649,843
Ensembl chr13:73,626,911...73,649,843
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [Asbestos, Serpentine results in increased secretion of TGFB1 protein]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of TGFB1 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of TGFB1 protein]
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]
CTD PMID:16365456 PMID:21613822 PMID:25358858 PMID:31447676 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Thpo thrombopoietin multiple interactions ISO pyrazolanthrone promotes the reaction [THPO protein results in increased expression of GP1BA protein]; pyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGA2B protein]; pyrazolanthrone promotes the reaction [THPO protein results in increased expression of ITGB3 protein] CTD PMID:20523355 NCBI chr16:20,724,454...20,734,511
Ensembl chr16:20,724,454...20,734,511
JBrowse link
G Thra thyroid hormone receptor alpha increases expression
multiple interactions
EXP pyrazolanthrone results in increased expression of THRA mRNA alternative form
[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA; IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; IL1B protein inhibits the reaction [pyrazolanthrone results in increased expression of THRA mRNA alternative form]
CTD PMID:17641275 NCBI chr11:98,740,776...98,769,006
Ensembl chr11:98,740,638...98,769,006
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP1 protein] CTD PMID:27060453 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 multiple interactions ISO pyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP2 protein] CTD PMID:27060453 NCBI chr11:118,301,061...118,355,411
Ensembl chr11:118,301,069...118,355,740
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
pyrazolanthrone affects the reaction [TNF protein results in increased expression of MMP9 protein]; pyrazolanthrone inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[ochratoxin A co-treated with Citrinin] results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [polyhexamethyleneguanidine results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of HNF4A mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of PPARA mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased activity of PLAU protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of and results in increased activity of MMP9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of CYP4F11 mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of F3 mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of PLAU protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK9 protein]
pyrazolanthrone inhibits the reaction [2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]]; pyrazolanthrone inhibits the reaction [7-Ala-angiotensin (1-7) inhibits the reaction [ACE2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Manganese promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]]; pyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [TNF protein affects the localization of RELA protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of OPTN protein]
6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]; pyrazolanthrone inhibits the reaction [[Cisplatin co-treated with TNF protein] results in increased expression of XAF1 mRNA]; pyrazolanthrone inhibits the reaction [[Polysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [bisphenol A results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Cisplatin inhibits the reaction [TNF protein affects the localization of RELA protein]]; pyrazolanthrone inhibits the reaction [deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Ozone results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of TNF mRNA]; pyrazolanthrone inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; pyrazolanthrone inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased susceptibility to Acetaminophen]; pyrazolanthrone inhibits the reaction [TNF protein results in increased susceptibility to Chlorpromazine]; pyrazolanthrone inhibits the reaction [trovafloxacin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; pyrazolanthrone inhibits the reaction [trovafloxacin results in increased expression of TNF mRNA]; pyrazolanthrone promotes the reaction [[Cisplatin co-treated with TNF protein] results in increased phosphorylation of JUN protein]
CTD PMID:12774022 PMID:14644621 PMID:15302094 PMID:15322261 PMID:16271621 PMID:16488514 PMID:17185352 PMID:17460151 PMID:17464197 PMID:18577375 PMID:19812349 PMID:19874453 PMID:19883121 PMID:20118172 PMID:20166895 PMID:20371967 PMID:20712904 PMID:20932985 PMID:21447443 PMID:22705379 PMID:22728154 PMID:22926441 PMID:23103562 PMID:23268108 PMID:23535185 PMID:23774252 PMID:23831309 PMID:24525298 PMID:25047101 PMID:25677194 PMID:26691871 PMID:27302421 PMID:28087840 PMID:28474156 PMID:28483571 PMID:28776281 PMID:29426002 PMID:29673704 PMID:29906494 PMID:30078834 PMID:30259999 PMID:31199065 PMID:31447676 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) multiple interactions EXP pyrazolanthrone inhibits the reaction [Alprostadil results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [Dinoprostone results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [FGF2 protein results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [Prostaglandin D2 results in increased secretion of TNFRSF11B protein] CTD PMID:24333336 PMID:24813642 PMID:25234201 PMID:25290095 PMID:25677506 NCBI chr15:54,250,619...54,278,484
Ensembl chr15:54,250,619...54,278,484
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions ISO pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of TNFSF10 mRNA]; pyrazolanthrone results in increased susceptibility to [[TNFSF10 protein co-treated with kahweol acetate] results in increased cleavage of PARP1 protein] CTD PMID:17545621 PMID:20403343 NCBI chr 3:27,317,077...27,339,665
Ensembl chr 3:27,317,028...27,342,427
JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions EXP [crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA; [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]; crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]; pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein] CTD PMID:30580027 NCBI chr14:78,277,446...78,308,043
Ensembl chr14:78,277,445...78,308,043
JBrowse link
G Tnni2 troponin I, skeletal, fast 2 multiple interactions EXP pyrazolanthrone promotes the reaction [Ozone results in increased expression of TNNI2 mRNA] CTD PMID:17460151 NCBI chr 7:142,441,816...142,444,410
Ensembl chr 7:142,441,808...142,444,410
JBrowse link
G Top1 topoisomerase (DNA) I multiple interactions ISO [pyrazolanthrone results in decreased phosphorylation of JUN protein] inhibits the reaction [JUN protein binds to TOP1 protein] CTD PMID:15923621 NCBI chr 2:160,645,897...160,722,764
Ensembl chr 2:160,645,888...160,722,764
JBrowse link
G Traf6 TNF receptor-associated factor 6 multiple interactions EXP [TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA] CTD PMID:30580027 NCBI chr 2:101,678,420...101,701,668
Ensembl chr 2:101,678,429...101,701,669
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions ISO pyrazolanthrone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TRHR protein] CTD PMID:22889935 NCBI chr15:44,195,924...44,235,912
Ensembl chr15:44,196,135...44,235,912
JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases phosphorylation
increases expression
decreases expression
ISO
EXP
[sodium arsenite co-treated with pyrazolanthrone] promotes the reaction [HSPA9 protein binds to TP53 protein modified form]; MYC affects the reaction [pyrazolanthrone results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of TP53 protein modified form]; pyrazolanthrone inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [Capsaicin results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein]; pyrazolanthrone inhibits the reaction [Cisplatin results in increased stability of TP53 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; pyrazolanthrone inhibits the reaction [Pyrogallol results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of TP53 protein]
pyrazolanthrone inhibits the reaction [Colistin results in increased expression of TP53 protein]
pyrazolanthrone results in increased phosphorylation of TP53 protein
pyrazolanthrone promotes the reaction [TRP53 gene mutant form results in decreased susceptibility to sodium arsenite]
pyrazolanthrone results in increased expression of TP53 protein; pyrazolanthrone results in increased expression of TP53 protein modified form
pyrazolanthrone results in decreased expression of TP53 protein
CTD PMID:15034932 PMID:16046226 PMID:16061660 PMID:16166651 PMID:16450001 PMID:17292493 PMID:20191265 PMID:22706169 PMID:25305377 PMID:25939952 PMID:26630137 PMID:28842171 PMID:31734849 PMID:32238696 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Twist1 twist basic helix-loop-helix transcription factor 1 multiple interactions ISO pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein] CTD PMID:27060453 NCBI chr12:33,957,671...33,959,831
Ensembl chr12:33,957,671...33,959,829
JBrowse link
G Uba7 ubiquitin-like modifier activating enzyme 7 decreases expression ISO pyrazolanthrone results in decreased expression of UBA7 protein CTD PMID:25649257 NCBI chr 9:107,975,567...107,984,056
Ensembl chr 9:107,975,505...107,984,060
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 multiple interactions ISO pyrazolanthrone inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA] CTD PMID:17256720 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO
EXP
pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of VCAM1 mRNA]; pyrazolanthrone inhibits the reaction [Cadmium results in increased expression of VCAM1 protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD PMID:16271621 PMID:19609071 PMID:28483571 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor multiple interactions ISO pyrazolanthrone inhibits the reaction [Estradiol results in increased expression of VDR protein] CTD PMID:15930183 NCBI chr15:97,854,427...97,908,296
Ensembl chr15:97,854,425...97,910,630
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA mRNA]; pyrazolanthrone inhibits the reaction [andrographolide results in decreased expression of VEGFA protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; pyrazolanthrone inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein] CTD PMID:18596194 PMID:19176594 PMID:23968725 PMID:28651835 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Vim vimentin multiple interactions ISO pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of VIM protein] CTD PMID:27060453 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
G Xaf1 XIAP associated factor 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [[Cisplatin co-treated with TNF protein] results in increased expression of XAF1 mRNA] CTD PMID:23103562 NCBI chr11:72,301,461...72,313,733
Ensembl chr11:72,301,629...72,313,733
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO pyrazolanthrone inhibits the reaction [trimethyltin chloride results in decreased expression of XIAP protein] CTD PMID:23423712 NCBI chr  X:42,059,613...42,109,664
Ensembl chr  X:42,059,679...42,109,656
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A multiple interactions ISO pyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased expression of ZC3H12A protein] CTD PMID:26865670 NCBI chr 4:125,118,414...125,127,881
Ensembl chr 4:125,118,423...125,127,840
JBrowse link
auraptene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions ISO aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] CTD PMID:18955043 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Ccna2 cyclin A2 affects expression ISO aurapten affects the expression of CCNA2 mRNA CTD PMID:23320178 NCBI chr 3:36,564,865...36,573,038
Ensembl chr 3:36,564,865...36,572,150
JBrowse link
G Ccnb2 cyclin B2 affects expression ISO aurapten affects the expression of CCNB2 mRNA CTD PMID:23320178 NCBI chr 9:70,407,689...70,421,554
Ensembl chr 9:70,407,692...70,421,547
JBrowse link
G Cdc45 cell division cycle 45 affects expression ISO aurapten affects the expression of CDC45 mRNA CTD PMID:23320178 NCBI chr16:18,780,447...18,811,972
Ensembl chr16:18,780,447...18,811,987
JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO aurapten affects the expression of CDK1 mRNA CTD PMID:23320178 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Cdkn2b cyclin dependent kinase inhibitor 2B affects expression ISO aurapten affects the expression of CDKN2B mRNA CTD PMID:23320178 NCBI chr 4:89,306,289...89,311,032
Ensembl chr 4:89,306,299...89,311,039
JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C affects expression ISO aurapten affects the expression of CDKN2C mRNA CTD PMID:23320178 NCBI chr 4:109,660,876...109,666,756
Ensembl chr 4:109,660,876...109,667,189
JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 NCBI chr 9:36,708,482...36,726,658
Ensembl chr 9:36,708,482...36,727,065
JBrowse link
G Chek2 checkpoint kinase 2 affects expression ISO aurapten affects the expression of CHEK2 mRNA CTD PMID:23320178 NCBI chr 5:110,839,800...110,874,140
Ensembl chr 5:110,839,979...110,874,145
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 decreases expression ISO aurapten results in decreased expression of CTNNB1 protein mutant form CTD PMID:16012713 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:20865247 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO aurapten affects the expression of DDIT3 mRNA CTD PMID:23320178 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression ISO aurapten affects the expression of DUSP1 mRNA CTD PMID:23320178 NCBI chr17:26,505,591...26,508,472
Ensembl chr17:26,505,590...26,562,128
JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO aurapten affects the expression of E2F1 mRNA CTD PMID:23320178 NCBI chr 2:154,559,400...154,569,892
Ensembl chr 2:154,559,407...154,569,892
JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO aurapten affects the expression of E2F2 mRNA CTD PMID:23320178 NCBI chr 4:136,172,274...136,196,057
Ensembl chr 4:136,172,394...136,196,057
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha affects expression ISO aurapten affects the expression of GADD45A mRNA CTD PMID:23320178 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Jun jun proto-oncogene affects expression ISO aurapten affects the expression of JUN mRNA CTD PMID:23320178 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Kif20b kinesin family member 20B affects expression ISO aurapten affects the expression of KIF20B mRNA CTD PMID:23320178 NCBI chr19:34,922,335...34,975,750
Ensembl chr19:34,922,361...34,975,745
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 affects expression ISO aurapten affects the expression of MCM3 mRNA CTD PMID:23320178 NCBI chr 1:20,802,966...20,820,312
Ensembl chr 1:20,802,968...20,820,312
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 affects expression ISO aurapten affects the expression of MCM6 mRNA CTD PMID:23320178 NCBI chr 1:128,331,575...128,359,705
Ensembl chr 1:128,331,590...128,359,664
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects response to substance EXP NFE2L2 protein affects the susceptibility to aurapten CTD PMID:19150646 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:20865247 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 affects expression ISO aurapten affects the expression of UHRF1 mRNA CTD PMID:23320178 NCBI chr17:56,303,337...56,323,486
Ensembl chr17:56,303,321...56,323,486
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] CTD PMID:20865247 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
binimetinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [NADP co-treated with binimetinib] results in decreased activity of CYP1A2 protein CTD PMID:33728909 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
cobimetinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) increases expression
multiple interactions
ISO cobimetinib results in increased expression of BCL2L11 protein; cobimetinib results in increased expression of BCL2L11 protein alternative form
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [cobimetinib results in increased expression of BCL2L11 protein alternative form]; 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [cobimetinib results in increased expression of BCL2L11 protein]; [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with cobimetinib] results in decreased phosphorylation of BCL2L11 protein alternative form; cobimetinib promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in increased expression of BCL2L11 protein alternative form]
CTD PMID:22084396 NCBI chr 2:128,126,038...128,162,547
Ensembl chr 2:128,126,038...128,162,547
JBrowse link
G Braf Braf transforming gene multiple interactions
increases response to substance
ISO 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [BRAF protein mutant form results in increased susceptibility to cobimetinib] CTD PMID:22084396 NCBI chr 6:39,603,231...39,725,658
Ensembl chr 6:39,603,237...39,725,463
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [cobimetinib results in decreased expression of CCND1 protein] CTD PMID:22084396 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases secretion ISO cobimetinib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog increases response to substance
multiple interactions
ISO KRAS protein mutant form results in increased susceptibility to cobimetinib
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [KRAS protein mutant form results in increased susceptibility to cobimetinib]; cobimetinib promotes the reaction [KRAS protein mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine]
CTD PMID:22084396 NCBI chr 6:145,216,699...145,250,420
Ensembl chr 6:145,216,699...145,250,239
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO cobimetinib results in decreased phosphorylation of MAPK1 protein CTD PMID:22084396 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation ISO cobimetinib results in decreased phosphorylation of MAPK3 protein CTD PMID:22084396 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Nras neuroblastoma ras oncogene increases response to substance ISO NRAS protein mutant form results in increased susceptibility to cobimetinib CTD PMID:22084396 NCBI chr 3:103,058,285...103,067,914
Ensembl chr 3:103,058,285...103,067,914
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage
multiple interactions
ISO cobimetinib results in increased cleavage of PARP1 protein
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [cobimetinib results in increased cleavage of PARP1 protein]; cobimetinib promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in increased cleavage of PARP1 protein]
CTD PMID:22084396 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO cobimetinib promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of RPS6 protein] CTD PMID:22084396 NCBI chr 4:86,854,099...86,857,367
Ensembl chr 4:86,854,660...86,857,412
JBrowse link
diosmetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 decreases activity ISO diosmetin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP1A1 protein CTD PMID:10781868 PMID:21482471 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO diosmetin results in decreased activity of CYP1A2 protein CTD PMID:28867436 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP1B1 protein CTD PMID:10781868 PMID:21482471 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases activity ISO diosmetin results in decreased activity of CYP2C8 protein CTD PMID:28867436 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases activity ISO diosmetin results in decreased activity of CYP2C19 protein CTD PMID:28867436 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases activity ISO diosmetin results in decreased activity of CYP2C9 protein CTD PMID:28867436 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 decreases activity ISO diosmetin results in decreased activity of CYP2C9 protein CTD PMID:28867436 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP2E1 protein CTD PMID:28867436 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions ISO diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP diosmetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:16934226 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP diosmetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:16934226 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Pkm pyruvate kinase, muscle increases activity ISO diosmetin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 9:59,656,576...59,679,372
Ensembl chr 9:59,656,368...59,679,375
JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO [diosmetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 3:104,638,664...104,658,462
Ensembl chr 3:104,638,668...104,658,462
JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions ISO diosmetin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:28867436 NCBI chr17:12,648,874...12,675,838
Ensembl chr17:12,648,869...12,675,829
JBrowse link
G Slco1a5 solute carrier organic anion transporter family, member 1a5 multiple interactions ISO diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium] CTD PMID:28867436 NCBI chr 6:142,234,227...142,322,981
Ensembl chr 6:142,234,227...142,322,981
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP diosmetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:16934226 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
diosmin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions EXP
ISO
Diosmin binds to and results in increased activity of AHR protein CTD PMID:14644660 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] CTD PMID:21477647 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899
JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] CTD PMID:32061149 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO
EXP
[Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]
CTD PMID:21477647 PMID:32061149 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]
CTD PMID:21477647 PMID:23665045 PMID:32061149 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] CTD PMID:23665045 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein] CTD PMID:23665045 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein] CTD PMID:22056647 PMID:23665045 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] CTD PMID:23665045 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Gsr glutathione reductase multiple interactions ISO
EXP
Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein]
CTD PMID:23665045 PMID:32061149 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein] CTD PMID:32061149 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein] CTD PMID:23665045 NCBI chr 7:135,689,784...135,716,450
Ensembl chr 7:135,689,784...135,716,361
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein] CTD PMID:23665045 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions EXP Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] CTD PMID:32061149 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein] CTD PMID:23665045 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]
CTD PMID:23665045 PMID:32061149 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] CTD PMID:32061149 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21477647 PMID:23665045 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein] CTD PMID:23665045 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO
EXP
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein]
CTD PMID:23665045 PMID:32061149 NCBI chr17:73,883,895...73,950,397
Ensembl chr17:73,883,895...73,950,196
JBrowse link
doramapimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 increases expression EXP BIRB 796 results in increased expression of ABCC2 mRNA CTD PMID:21328587 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Actg2 actin, gamma 2, smooth muscle, enteric increases expression ISO BIRB 796 results in increased expression of ACTG2 mRNA CTD PMID:24303162 NCBI chr 6:83,512,909...83,536,251
Ensembl chr 6:83,512,905...83,536,265
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide increases expression ISO BIRB 796 results in increased expression of ADH7 mRNA CTD PMID:24303162 NCBI chr 3:138,198,064...138,232,042
Ensembl chr 3:138,217,760...138,233,382
JBrowse link
G Ahsg alpha-2-HS-glycoprotein decreases expression EXP BIRB 796 results in decreased expression of AHSG mRNA CTD PMID:21328587 NCBI chr16:22,892,015...22,899,451
Ensembl chr16:22,891,277...22,899,449
JBrowse link
G Ak5 adenylate kinase 5 increases expression ISO BIRB 796 results in increased expression of AK5 mRNA CTD PMID:24303162 NCBI chr 3:152,462,815...152,668,406
Ensembl chr 3:152,462,815...152,668,360
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases expression EXP BIRB 796 results in increased expression of AKR1B7 mRNA CTD PMID:21328587 NCBI chr 6:34,412,362...34,423,137
Ensembl chr 6:34,412,334...34,423,142
JBrowse link
G Apoa4 apolipoprotein A-IV decreases expression EXP BIRB 796 results in decreased expression of APOA4 mRNA CTD PMID:21328587 NCBI chr 9:46,240,844...46,243,458
Ensembl chr 9:46,240,696...46,243,459
JBrowse link
G C1qa complement component 1, q subcomponent, alpha polypeptide decreases expression EXP BIRB 796 results in decreased expression of C1QA mRNA CTD PMID:21328587 NCBI chr 4:136,895,916...136,898,844
Ensembl chr 4:136,895,917...136,898,803
JBrowse link
G C1qb complement component 1, q subcomponent, beta polypeptide decreases expression EXP BIRB 796 results in decreased expression of C1QB mRNA CTD PMID:21328587 NCBI chr 4:136,880,126...136,886,200
Ensembl chr 4:136,880,129...136,886,187
JBrowse link
G Car3 carbonic anhydrase 3 decreases expression EXP BIRB 796 results in decreased expression of CAR3 mRNA CTD PMID:21328587 NCBI chr 3:14,863,538...14,872,381
Ensembl chr 3:14,863,512...14,872,523
JBrowse link
G Cd5l CD5 antigen-like decreases expression EXP BIRB 796 results in decreased expression of CD5L mRNA CTD PMID:21328587 NCBI chr 3:87,357,881...87,371,074
Ensembl chr 3:87,357,881...87,371,073
JBrowse link
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) decreases expression EXP BIRB 796 results in decreased expression of CD74 mRNA CTD PMID:21328587 NCBI chr18:60,803,849...60,812,652
Ensembl chr18:60,803,848...60,812,652
JBrowse link
G Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 decreases expression ISO BIRB 796 results in decreased expression of CEACAM1 mRNA CTD PMID:24303162 NCBI chr 7:25,461,702...25,477,647
Ensembl chr 7:25,461,707...25,477,603
JBrowse link
G Ces3b carboxylesterase 3B increases expression EXP BIRB 796 results in increased expression of CES3 mRNA CTD PMID:21328587 NCBI chr 8:105,083,733...105,093,929
Ensembl chr 8:105,083,753...105,093,929
JBrowse link
G Clec1b C-type lectin domain family 1, member b decreases expression EXP BIRB 796 results in decreased expression of CLEC1B mRNA CTD PMID:21328587 NCBI chr 6:129,397,297...129,405,413
Ensembl chr 6:129,397,297...129,409,335
JBrowse link
G Ctss cathepsin S decreases expression EXP BIRB 796 results in decreased expression of CTSS mRNA CTD PMID:21328587 NCBI chr 3:95,526,786...95,556,405
Ensembl chr 3:95,526,786...95,556,403
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 multiple interactions ISO BIRB 796 inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:14997032 NCBI chr 5:90,891,245...90,893,121
Ensembl chr 5:90,891,241...90,893,115
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 decreases secretion ISO BIRB 796 results in decreased secretion of CXCL10 protein CTD PMID:17996064 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO BIRB 796 inhibits the reaction [Dinitrofluorobenzene results in increased secretion of CXCL8 protein]; BIRB 796 inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein] CTD PMID:14997032 PMID:19427879 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 multiple interactions ISO BIRB 796 inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:14997032 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Cxcr1 chemokine (C-X-C motif) receptor 1 multiple interactions ISO BIRB 796 inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR1 protein] CTD PMID:14997032 NCBI chr 1:74,191,785...74,194,708
Ensembl chr 1:74,191,785...74,194,631
JBrowse link
G Cxcr2 chemokine (C-X-C motif) receptor 2 multiple interactions ISO BIRB 796 inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR2 protein] CTD PMID:14997032 NCBI chr 1:74,153,994...74,161,246
Ensembl chr 1:74,153,989...74,161,246
JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 increases expression EXP BIRB 796 results in increased expression of CYP2A4 mRNA CTD PMID:21328587 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 increases expression EXP BIRB 796 results in increased expression of CYP2A5 mRNA CTD PMID:21328587 NCBI chr 7:26,835,339...26,843,264
Ensembl chr 7:26,835,305...26,843,548
JBrowse link
G Egr1 early growth response 1 increases expression EXP BIRB 796 results in increased expression of EGR1 mRNA CTD PMID:21328587 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Fcgr2b Fc receptor, IgG, low affinity IIb decreases expression EXP BIRB 796 results in decreased expression of FCGR2B mRNA CTD PMID:21328587 NCBI chr 1:170,960,558...170,976,071
Ensembl chr 1:170,958,617...170,976,547
JBrowse link
G Fgf8 fibroblast growth factor 8 decreases expression ISO BIRB 796 results in decreased expression of FGF8 mRNA CTD PMID:24303162 NCBI chr19:45,736,491...45,742,941
Ensembl chr19:45,736,798...45,742,915
JBrowse link
G G6pc glucose-6-phosphatase, catalytic decreases expression EXP BIRB 796 results in decreased expression of G6PC mRNA CTD PMID:21328587 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP BIRB 796 results in increased expression of GCLC mRNA CTD PMID:21328587 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP BIRB 796 results in increased expression of GPX2 mRNA CTD PMID:21328587 NCBI chr12:76,792,335...76,795,554
Ensembl chr12:76,792,333...76,795,554
JBrowse link
G Grm8 glutamate receptor, metabotropic 8 increases expression ISO BIRB 796 results in increased expression of GRM8 mRNA CTD PMID:24303162 NCBI chr 6:27,275,121...28,135,146
Ensembl chr 6:27,275,119...28,135,178
JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) increases expression EXP BIRB 796 results in increased expression of GSTA1 mRNA CTD PMID:21328587 NCBI chr 9:78,230,669...78,242,683
Ensembl chr 9:78,230,656...78,242,684
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) increases expression EXP BIRB 796 results in increased expression of GSTA2 mRNA CTD PMID:21328587 NCBI chr 9:78,331,018...78,347,192
Ensembl chr 9:78,331,018...78,355,788
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 increases expression EXP BIRB 796 results in increased expression of GSTM2 mRNA CTD PMID:21328587 NCBI chr 3:107,981,702...107,986,420
Ensembl chr 3:107,981,702...107,986,453
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression EXP BIRB 796 results in increased expression of GSTM3 mRNA CTD PMID:21328587 NCBI chr 3:107,895,854...107,898,685
Ensembl chr 3:107,895,821...107,898,686
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 decreases expression EXP BIRB 796 results in decreased expression of H2-AB1 mRNA CTD PMID:21328587 NCBI chr17:34,263,227...34,269,418
Ensembl chr17:34,257,689...34,269,419
JBrowse link
G Hp haptoglobin decreases expression EXP BIRB 796 results in decreased expression of HP mRNA CTD PMID:21328587 NCBI chr 8:109,575,128...109,579,172
Ensembl chr 8:109,575,128...109,579,172
JBrowse link
G Hpd 4-hydroxyphenylpyruvic acid dioxygenase decreases expression ISO BIRB 796 results in decreased expression of HPD mRNA CTD PMID:24303162 NCBI chr 5:123,171,807...123,182,723
Ensembl chr 5:123,171,807...123,182,727
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO BIRB 796 inhibits the reaction [Dinitrofluorobenzene results in increased expression of ICAM1 protein] CTD PMID:19427879 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Kcnk1 potassium channel, subfamily K, member 1 decreases expression ISO BIRB 796 results in decreased expression of KCNK1 mRNA CTD PMID:24303162 NCBI chr 8:125,993,655...126,030,685
Ensembl chr 8:125,995,170...126,030,685
JBrowse link
G Lmod1 leiomodin 1 (smooth muscle) increases expression ISO BIRB 796 results in increased expression of LMOD1 mRNA CTD PMID:24303162 NCBI chr 1:135,324,813...135,368,065
Ensembl chr 1:135,324,807...135,368,065
JBrowse link
G Meig1 meiosis expressed gene 1 increases expression EXP BIRB 796 results in increased expression of MEIG1 mRNA CTD PMID:21328587 NCBI chr 2:3,409,043...3,422,648
Ensembl chr 2:3,409,043...3,422,648
JBrowse link
G Mt1 metallothionein 1 increases expression EXP BIRB 796 results in increased expression of MT1 mRNA CTD PMID:21328587 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327
JBrowse link
G Mybpc1 myosin binding protein C, slow-type decreases expression ISO BIRB 796 results in decreased expression of MYBPC1 mRNA CTD PMID:24303162 NCBI chr10:88,518,279...88,605,229
Ensembl chr10:88,518,279...88,605,152
JBrowse link
G Myh11 myosin, heavy polypeptide 11, smooth muscle increases expression ISO BIRB 796 results in increased expression of MYH11 mRNA CTD PMID:24303162 NCBI chr16:14,194,527...14,292,188
Ensembl chr16:14,194,535...14,291,372
JBrowse link
G Myh3 myosin, heavy polypeptide 3, skeletal muscle, embryonic increases expression ISO BIRB 796 results in increased expression of MYH3 mRNA CTD PMID:24303162 NCBI chr11:67,078,273...67,102,291
Ensembl chr11:67,078,300...67,102,291
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression EXP BIRB 796 results in increased expression of NQO1 mRNA CTD PMID:21328587 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Olfr78 olfactory receptor 78 increases expression ISO BIRB 796 results in increased expression of OLR59 mRNA CTD PMID:24303162 NCBI chr 7:102,740,721...102,759,471
Ensembl chr 7:102,738,511...102,759,471
JBrowse link
G Otog otogelin decreases expression ISO BIRB 796 results in decreased expression of OTOG mRNA CTD PMID:24303162 NCBI chr 7:46,240,987...46,311,434
Ensembl chr 7:46,240,987...46,311,434
JBrowse link
G Pfn2 profilin 2 increases expression EXP BIRB 796 results in increased expression of PFN2 mRNA CTD PMID:21328587 NCBI chr 3:57,841,895...57,847,757
Ensembl chr 3:57,841,895...57,848,079
JBrowse link
G Pon1 paraoxonase 1 decreases expression ISO BIRB 796 results in decreased expression of PON1 mRNA CTD PMID:24303162 NCBI chr 6:5,168,090...5,193,987
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression EXP BIRB 796 results in increased expression of PPARG mRNA CTD PMID:21328587 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Prm2 protamine 2 increases expression EXP BIRB 796 results in increased expression of PRM2 mRNA CTD PMID:21328587 NCBI chr16:10,791,377...10,792,105
Ensembl chr16:10,791,380...10,796,134
JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression ISO BIRB 796 results in increased expression of RGS4 mRNA CTD PMID:24303162 NCBI chr 1:169,741,477...169,747,642
Ensembl chr 1:169,741,477...169,747,642
JBrowse link
G Serpina1a serine (or cysteine) peptidase inhibitor, clade A, member 1A decreases expression EXP BIRB 796 results in decreased expression of SERPINA1A mRNA CTD PMID:21328587 NCBI chr12:103,853,295...103,863,619
Ensembl chr12:103,853,589...103,863,562
JBrowse link
G Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C decreases expression EXP BIRB 796 results in decreased expression of SERPINA1C mRNA CTD PMID:21328587 NCBI chr12:103,894,926...103,904,950
Ensembl chr12:103,894,926...103,904,887
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 increases expression EXP BIRB 796 results in increased expression of SLC7A11 mRNA CTD PMID:21328587 NCBI chr 3:50,364,936...50,499,087
Ensembl chr 3:49,892,526...50,443,614
JBrowse link
G Spock2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 decreases expression ISO BIRB 796 results in decreased expression of SPOCK2 mRNA CTD PMID:24303162 NCBI chr10:60,106,257...60,135,198
Ensembl chr10:60,106,219...60,135,198
JBrowse link
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 decreases expression EXP BIRB 796 results in decreased expression of SPSB1 mRNA CTD PMID:21328587 NCBI chr 4:149,896,283...149,955,006
Ensembl chr 4:149,896,283...149,955,043
JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression EXP BIRB 796 results in increased expression of SRXN1 mRNA CTD PMID:21328587 NCBI chr 2:152,105,524...152,111,376
Ensembl chr 2:152,105,516...152,111,376
JBrowse link
G Stmn2 stathmin-like 2 increases expression ISO BIRB 796 results in increased expression of STMN2 mRNA CTD PMID:24303162 NCBI chr 3:8,509,527...8,561,604
Ensembl chr 3:8,509,360...8,561,606
JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 decreases expression EXP BIRB 796 results in decreased expression of VSIG4 mRNA CTD PMID:21328587 NCBI chr  X:96,247,201...96,293,438
Ensembl chr  X:96,247,203...96,293,438
JBrowse link
G Wfdc15b WAP four-disulfide core domain 15B decreases expression EXP BIRB 796 results in decreased expression of WFDC15B mRNA CTD PMID:21328587 NCBI chr 2:164,214,454...164,221,663
Ensembl chr 2:164,214,454...164,221,660
JBrowse link
G Zfp324 zinc finger protein 324 increases expression EXP BIRB 796 results in increased expression of ZFP324 mRNA CTD PMID:21328587 NCBI chr 7:12,965,838...12,974,244
Ensembl chr 7:12,965,838...12,974,236
JBrowse link
eupatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases response to substance
increases metabolic processing
decreases activity
increases expression
ISO CYP1A1 protein results in increased susceptibility to eupatorin
CYP1A1 protein results in increased metabolism of eupatorin analog
eupatorin analog results in decreased activity of CYP1A1 protein
eupatorin results in increased expression of CYP1A1 mRNA
CTD PMID:18454852 PMID:19601638 PMID:21482471 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
increases expression
decreases activity
ISO CYP1B1 protein results in increased metabolism of eupatorin analog
eupatorin results in increased expression of CYP1B1 mRNA
eupatorin results in decreased activity of CYP1B1 protein
CTD PMID:19601638 PMID:21482471 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases activity ISO eupatorin results in decreased activity of CYP2C19 protein CTD PMID:21093571 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity ISO eupatorin results in decreased activity of CYP2D6 protein CTD PMID:21276781 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
isoorientin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] CTD PMID:22446813 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation
multiple interactions
ISO homoorientin results in decreased phosphorylation of AKT1 protein
homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of AKT1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of AKT1 protein]
CTD PMID:24374571 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of BCL2 mRNA] CTD PMID:22446813 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Il6 interleukin 6 multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of IL6 protein] CTD PMID:22446813 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK1 protein] CTD PMID:24374571 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK3 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK3 protein] CTD PMID:24374571 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:22446813 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of TGFB1 protein] CTD PMID:22446813 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO homoorientin inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:22446813 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
luteolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 decreases activity ISO Luteolin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 multiple interactions EXP [Luteolin co-treated with Cisplatin] results in increased expression of ABCC2 protein; Luteolin inhibits the reaction [Cisplatin results in increased expression of ABCC2 protein] CTD PMID:23770416 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 multiple interactions EXP Luteolin inhibits the reaction [Cisplatin results in increased expression of ABCC4 protein] CTD PMID:23770416 NCBI chr14:118,482,692...118,707,856
Ensembl chr14:118,482,692...118,706,219
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) affects activity ISO Luteolin affects the activity of ABCG2 protein CTD PMID:20403331 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Luteolin inhibits the reaction [cobaltous chloride results in increased activity of ACHE protein] CTD PMID:31362009 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions EXP Luteolin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:19747501 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Luteolin inhibits the reaction [Glucose results in increased expression of AGER mRNA] CTD PMID:19557821 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO
EXP
Luteolin binds to and results in decreased activity of AHR protein
Luteolin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
CTD PMID:14644660 PMID:20450880 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
increases phosphorylation
decreases expression
ISO
EXP
Luteolin inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]
Luteolin results in decreased phosphorylation of AKT1 protein
Luteolin results in increased phosphorylation of AKT1 protein
Luteolin inhibits the reaction [Antimycin A results in decreased activity of AKT1 protein]; Luteolin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
[Luteolin co-treated with Hydrogen Peroxide] results in increased expression of AKT1 protein; Luteolin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [Methamphetamine results in increased phosphorylation of AKT1 protein]
Luteolin results in decreased expression of AKT1 protein
CTD PMID:18591783 PMID:18720166 PMID:19344998 PMID:20153296 PMID:20685402 PMID:21782929 PMID:22926442 PMID:25448439 PMID:27474067 PMID:27525270 PMID:32035215 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO Luteolin inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4] CTD PMID:18096136 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Asns asparagine synthetase multiple interactions ISO Luteolin inhibits the reaction [Tunicamycin results in increased expression of ASNS mRNA] CTD PMID:32407927 NCBI chr 6:7,675,165...7,693,209
Ensembl chr 6:7,675,169...7,693,254
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Luteolin inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein modified form]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of ATF6 protein modified form] CTD PMID:32407927 NCBI chr 1:170,704,457...170,868,585
Ensembl chr 1:170,704,674...170,867,771
JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions
ISO Luteolin results in increased expression of ATG5 protein
Luteolin inhibits the reaction [Methamphetamine results in increased expression of ATG5 protein]
CTD PMID:32035215 PMID:32268164 NCBI chr10:44,268,322...44,364,299
Ensembl chr10:44,268,358...44,364,291
JBrowse link
G Atp7b ATPase, Cu++ transporting, beta polypeptide increases expression ISO Luteolin results in increased expression of ATP7B mRNA CTD PMID:31201582 NCBI chr 8:21,992,783...22,060,074
Ensembl chr 8:21,992,785...22,060,305
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO Luteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Luteolin inhibits the reaction [Methamphetamine results in increased expression of BAX protein]
Luteolin results in increased expression of BAX protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased expression of BAX protein]
CTD PMID:21601631 PMID:27474067 PMID:27525270 PMID:32035215 PMID:32268164 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in decreased expression of BCL2 protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of BCL2 protein]; Luteolin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein] CTD PMID:19557821 PMID:25448439 PMID:27474067 PMID:32268164 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions
ISO Luteolin results in decreased expression of BCL2L1 protein
Luteolin inhibits the reaction [chromium hexavalent ion results in increased expression of BCL2L1 protein]
CTD PMID:21601631 PMID:25448439 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
increases expression
ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of BECN1 protein]
Luteolin results in increased expression of BECN1 protein
CTD PMID:32035215 PMID:32268164 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO Luteolin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] CTD PMID:15334063 NCBI chr 9:7,818,226...7,837,131
Ensembl chr 9:7,818,227...7,837,064
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Luteolin inhibits the reaction [Freund's Adjuvant results in increased cleavage of CASP1 protein] CTD PMID:25450234 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression
increases activity
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased cleavage of CASP3 protein]; [Luteolin co-treated with Paclitaxel] results in increased cleavage of CASP3 protein; Luteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP3 protein]; Luteolin results in increased expression of and results in increased cleavage of CASP3 protein
Luteolin results in increased expression of CASP3 protein
Luteolin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Luteolin inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]
Luteolin results in increased activity of CASP3 protein
Luteolin inhibits the reaction [Cisplatin results in increased cleavage of and results in increased expression of CASP3 protein]; Luteolin inhibits the reaction [Tunicamycin results in increased expression of CASP3 protein modified form]
CTD PMID:16140950 PMID:18331776 PMID:19397994 PMID:21074525 PMID:21601631 PMID:23770416 PMID:24525192 PMID:27474067 PMID:27489195 PMID:27525270 PMID:31201582 PMID:31288002 PMID:32035215 PMID:32268164 PMID:32407927 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp7 caspase 7 increases activity ISO Luteolin results in increased activity of CASP7 protein CTD PMID:21074525 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Luteolin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein; Luteolin promotes the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein]; Luteolin promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]
Luteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]
CTD PMID:15334063 PMID:16140950 PMID:24525192 PMID:27525270 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage
ISO Luteolin results in increased activity of CASP9 protein
Luteolin results in increased cleavage of CASP9 protein
CTD PMID:18331776 PMID:19397994 PMID:21601631 PMID:27474067 PMID:27489195 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase affects activity
decreases activity
multiple interactions
ISO
EXP
Luteolin affects the activity of CAT protein
Luteolin results in decreased activity of CAT protein
Fluorouracil promotes the reaction [Luteolin results in decreased activity of CAT protein]; Luteolin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; Luteolin promotes the reaction [Fluorouracil results in decreased activity of CAT protein]
CTD PMID:18503759 PMID:31288002 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
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G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO Luteolin inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] CTD PMID:24134915 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
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G Ccn5 cellular communication network factor 5 decreases expression ISO Luteolin results in decreased expression of CCN5 mRNA CTD PMID:19397994 NCBI chr 2:163,820,752...163,833,146
Ensembl chr 2:163,820,861...163,833,146
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G Ccna2 cyclin A2 decreases expression ISO Luteolin results in decreased expression of CCNA2 protein CTD PMID:22926442 NCBI chr 3:36,564,865...36,573,038
Ensembl chr 3:36,564,865...36,572,150
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G Ccnb1 cyclin B1 decreases expression ISO Luteolin results in decreased expression of CCNB1 mRNA; Luteolin results in decreased expression of CCNB1 protein CTD PMID:18331776 PMID:19397994 PMID:22926442 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
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G Ccnd1 cyclin D1 multiple interactions
decreases expression
EXP Fluorouracil promotes the reaction [Luteolin results in decreased expression of CCND1 protein]; Luteolin promotes the reaction [Fluorouracil results in decreased expression of CCND1 protein] CTD PMID:31288002 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
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G Cd40 CD40 antigen multiple interactions ISO Luteolin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]; Luteolin inhibits the reaction [Calcimycin results in increased expression of CD40 protein]; Luteolin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD40 protein] CTD PMID:16601352 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
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G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) decreases expression ISO Luteolin results in decreased expression of CD74 mRNA CTD PMID:18818744 NCBI chr18:60,803,849...60,812,652
Ensembl chr18:60,803,848...60,812,652
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G Cdh1 cadherin 1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in increased expression of CDH1 protein] CTD PMID:27474067 PMID:32268164 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
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G Cdh2 cadherin 2 multiple interactions
decreases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Luteolin results in decreased expression of CDH2 protein] CTD PMID:27474067 NCBI chr18:16,588,877...16,809,246
Ensembl chr18:16,588,877...16,809,246
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G Cdh5 cadherin 5 multiple interactions ISO Luteolin inhibits the reaction [Methamphetamine results in increased expression of CDH5 mRNA] CTD