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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:SB-202190
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Accession:CHEBI:79090 term browser browse the term
Definition:A member of the class of imidazoles that is 1H-imidazole in which the hydrogens at positions 2, 4, and 5 are replaced by 4-hydroxyphenyl, pyridin-4-yl, and 4-fluorophenyl groups, respectively. It is a widely used inhibitor of mitogen-activated protein kinase (MAPK) alpha and beta.
Synonyms:exact_synonym: 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
 related_synonym: 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole;   Formula=C20H14FN3O;   InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24);   InChIKey=QHKYPYXTTXKZST-UHFFFAOYSA-N;   SB202190;   SMILES=Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
 xref: CAS:152121-30-7;   PMID:11040446;   PMID:16183336;   PMID:18995898;   PMID:21853067;   PMID:22253611;   PMID:22986232;   PMID:24455679;   PMID:9632706;   PMID:9738669;   Reaxys:10467168



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SB-202190 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO SB-202190 inhibits the reaction [benzo[a]pyrene and polycyclic arene increases expression of CYP1A1 mRNA in lung epithelial cell] RGD PMID:20464547 RGD:152975620 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Fgf9 fibroblast growth factor 9 multiple interactions ISO SB-202190 inhibits the reaction [ benzo[a]pyrene and polycyclic arene increases expression of FGF9 mRNA in lung epithelial cell] RGD PMID:20464547 RGD:152975620 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO SB-202190 inhibits the reaction [benzo[a]pyrene and polycyclic arene increases expression of IL1A mRNA in lung epithelial cell] RGD PMID:20464547 RGD:152975620 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link

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  CHEBI ontology 20060
    role 20014
      biological role 20013
        biochemical role 19652
          apoptosis inducer 13442
            SB-202190 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20060
    subatomic particle 20059
      composite particle 20059
        hadron 20059
          baryon 20059
            nucleon 20059
              atomic nucleus 20059
                atom 20059
                  main group element atom 19962
                    p-block element atom 19962
                      carbon group element atom 19892
                        carbon atom 19885
                          organic molecular entity 19885
                            organic molecule 19833
                              organic cyclic compound 19594
                                organic heterocyclic compound 18880
                                  heteroarene 16617
                                    monocyclic heteroarene 13615
                                      azole 12846
                                        diazole 8632
                                          imidazoles 7727
                                            SB-202190 3
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