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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 3.4.22.52 (calpain-1) inhibitor
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Accession:CHEBI:79050 term browser browse the term
Definition:A calpain inhibitor that interferes with the action of calpain-1 (EC 3.4.22.52).
Synonyms:related_synonym: EC 3.4.22.52 (calpain-1) inhibitors;   EC 3.4.22.52 inhibitor;   EC 3.4.22.52 inhibitors;   calcium-activated neutral protease I inhibitor;   calcium-activated neutral protease I inhibitors;   calpain-1 inhibitor;   calpain-1 inhibitors;   mu-calpain inhibitor;   mu-calpain inhibitors
 xref: Wikipedia:Calpain-1


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Z-Val-Phe-H term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO calpain inhibitor III inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein] CTD PMID:16891617 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions EXP calpain inhibitor III inhibits the reaction [Isoflurane results in increased cleavage of and affects the localization of AIFM1 protein] CTD PMID:29289695 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Capn1 calpain 1 multiple interactions
decreases activity		 ISO
EXP		 calpain inhibitor III inhibits the reaction [CAPN1 protein results in increased susceptibility to Cisplatin]
calpain inhibitor III results in decreased activity of CAPN1 protein
calpain inhibitor III inhibits the reaction [Calcium results in increased activity of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN1 protein]; calpain inhibitor III inhibits the reaction [Manganese results in increased activity of CAPN1 protein]		 CTD PMID:13678654 PMID:20878076 PMID:21985864 PMID:29289695 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Capn2 calpain 2 multiple interactions EXP calpain inhibitor III inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein] CTD PMID:29289695 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO calpain inhibitor III inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:16891617 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO calpain inhibitor III inhibits the reaction [deoxynivalenol results in increased degradation of HSPA5 protein] CTD PMID:19336499 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il1a interleukin 1 alpha affects localization ISO calpain inhibitor III affects the localization of IL1A protein CTD PMID:24024155 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Nefl neurofilament light chain multiple interactions EXP calpain inhibitor III inhibits the reaction [Zymosan results in increased degradation of NEFL protein] CTD PMID:15275793 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO calpain inhibitor III inhibits the reaction [Thioacetamide results in increased expression of NOS2 mRNA] CTD PMID:15316131 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 multiple interactions ISO
EXP		 calpain inhibitor III inhibits the reaction [lactacystin results in increased cleavage of SPTAN1 protein]
calpain inhibitor III inhibits the reaction [Manganese results in increased cleavage of SPTAN1 protein]		 CTD PMID:21683092 PMID:21985864 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO calpain inhibitor III inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA] CTD PMID:15316131 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        inhibitor 18895
          enzyme inhibitor 18723
            EC 3.* (hydrolase) inhibitor 18327
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 4424
                EC 3.4.22.* (cysteine endopeptidase) inhibitor 1779
                  calpain inhibitor 35
                    EC 3.4.22.52 (calpain-1) inhibitor 11
                      (-)-epicatechin-5-gallate 0
                      Z-Val-Phe-H 11
                      calpastatin peptide Ac 184-210 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        inhibitor 18895
          enzyme inhibitor 18723
            EC 3.* (hydrolase) inhibitor 18327
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 4424
                protease inhibitor 2249
                  cysteine protease inhibitor 573
                    calpain inhibitor 35
                      EC 3.4.22.52 (calpain-1) inhibitor 11
                        (-)-epicatechin-5-gallate 0
                        Z-Val-Phe-H 11
                        calpastatin peptide Ac 184-210 0
paths to the root