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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(-)-Arctigenin
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Accession:CHEBI:79 term browser browse the term
Definition:A lignan that has formula C21H24O6.
Synonyms:related_synonym: Formula=C21H24O6;   InChI=1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1;   InChIKey=NQWVSMVXKMHKTF-JKSUJKDBSA-N;   SMILES=COc1cc(C[C@@H]2[C@@H](Cc3ccc(OC)c(OC)c3)COC2=O)ccc1O
 xref: CAS:7770-78-7;   HMDB:HMDB0030087;   KEGG:C10545;   KNApSAcK:C00000609;   LINCS:LSM-3183
 xref_mesh: MESH:C071942


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(-)-Arctigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [Quercetin co-treated with arctigenin] results in decreased expression of AKT1 protein; arctigenin promotes the reaction [Quercetin results in decreased phosphorylation of AKT1 protein]; arctigenin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Quercetin promotes the reaction [arctigenin results in decreased phosphorylation of AKT1 protein] CTD PMID:25380086 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt1s1 AKT1 substrate 1 decreases phosphorylation
multiple interactions
ISO arctigenin results in decreased phosphorylation of AKT1S1 protein
Quercetin promotes the reaction [arctigenin results in decreased phosphorylation of AKT1S1 protein]
CTD PMID:25380086 NCBI chr 1:100,845,443...100,851,961
Ensembl chr 1:100,845,563...100,851,960
JBrowse link
G Ar androgen receptor decreases expression
multiple interactions
ISO arctigenin results in decreased expression of AR protein
[Quercetin co-treated with arctigenin] results in decreased expression of AR protein
CTD PMID:25380086 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases phosphorylation
ISO Quercetin promotes the reaction [arctigenin results in decreased phosphorylation of BAD protein] CTD PMID:25380086 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO arctigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL2 protein] CTD PMID:21426947 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases phosphorylation
ISO Quercetin promotes the reaction [arctigenin results in decreased phosphorylation of GSK3B protein] CTD PMID:25380086 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO arctigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein] CTD PMID:21426947 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO arctigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein] CTD PMID:21426947 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO arctigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein] CTD PMID:21426947 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Mir148a microRNA 148a multiple interactions
decreases expression
ISO arctigenin promotes the reaction [Quercetin results in decreased expression of MIR148A mRNA]; Quercetin promotes the reaction [arctigenin results in decreased expression of MIR148A mRNA] CTD PMID:25380086 NCBI chr 4:81,013,269...81,013,365
Ensembl chr 4:81,013,269...81,013,365
JBrowse link
G Mir21 microRNA 21 multiple interactions
decreases expression
ISO arctigenin inhibits the reaction [Quercetin results in increased expression of MIR21 mRNA]
arctigenin results in decreased expression of MIR21 mRNA
CTD PMID:25380086 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO Quercetin promotes the reaction [arctigenin results in decreased phosphorylation of MTOR protein] CTD PMID:25380086 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nkx3-1 NK3 homeobox 1 multiple interactions
increases expression
ISO [Quercetin co-treated with arctigenin] results in increased expression of NKX3-1 protein
arctigenin results in increased expression of NKX3-1 protein
CTD PMID:25380086 NCBI chr15:51,065,316...51,067,908
Ensembl chr15:51,065,316...51,068,421
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO arctigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; arctigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein] CTD PMID:21426947 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO arctigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:21426947 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO arctigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and affects the localization of STAT1 protein] CTD PMID:21426947 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO arctigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and affects the localization of STAT3 protein]
Quercetin promotes the reaction [arctigenin results in decreased phosphorylation of STAT3 protein]
CTD PMID:21426947 PMID:25380086 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19783
    chemical entity 19783
      group 19701
        polyatomic entity 19700
          molecule 19540
            cyclic compound 19372
              organic cyclic compound 19336
                organic aromatic compound 19160
                  phenylpropanoid 9375
                    lignan 1626
                      (-)-Arctigenin 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19783
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      p-block molecular entity 19670
                        carbon group molecular entity 19588
                          organic molecular entity 19578
                            organic molecule 19510
                              organic cyclic compound 19336
                                organic aromatic compound 19160
                                  phenylpropanoid 9375
                                    lignan 1626
                                      (-)-Arctigenin 17
paths to the root