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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(omega-1)-hydroxy fatty acid
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Accession:CHEBI:78954 term browser browse the term
Definition:A hydroxy fatty acid that is a straight-chain fatty acid in which one of the hydrogens attached to the carbon adjacent to the terminal methyl group (i.e. at the (omega-1) position) is replaced by a hydroxy group.
Synonyms:related_synonym: (omega-1)-hydroxy fatty acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:84497



show annotations for term's descendants           Sort by:
3-hydroxybutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO 3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ACSL4 protein]]; 3-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACSL4 protein]; 3-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ACSL4 protein] CTD PMID:36435477 NCBI chr  X:110,739,633...110,803,416
Ensembl chr  X:110,739,648...110,803,261
JBrowse link
G Aqp9 aquaporin 9 increases uptake EXP AQP9 protein results in increased uptake of 3-Hydroxybutyric Acid CTD PMID:9733774 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240
JBrowse link
G Atg5 autophagy related 5 increases abundance ISO ATG5 protein results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:25943029 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821
JBrowse link
G Becn1 beclin 1 increases abundance ISO BECN1 protein results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:25943029 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [Rotenone results in increased activity of CASP3 protein]
3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of CASP3 protein]
CTD PMID:16917840 PMID:31332890 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of CASP8 protein] CTD PMID:31332890 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
JBrowse link
G Casp9 caspase 9 multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [Rotenone results in increased activity of CASP9 protein]
3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of CASP9 protein]
CTD PMID:16917840 PMID:31332890 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor multiple interactions
decreases abundance
ISO 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of UCP2 protein]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased acetylation of TP53 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]]
Dietary Fats inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of 3-Hydroxybutyric Acid]
CTD PMID:25440059 NCBI chr16:7,771,311...7,841,895
Ensembl chr16:7,771,581...7,841,895
JBrowse link
G Ffar3 free fatty acid receptor 3 decreases activity
multiple interactions
ISO 3-Hydroxybutyric Acid results in decreased activity of FFAR3 protein
3-Hydroxybutyric Acid inhibits the reaction [3-(indol-3-yl)propionic acid results in increased activity of FFAR3 protein]
CTD PMID:35509122 NCBI chr 1:95,232,804...95,234,144
Ensembl chr 1:95,232,336...95,234,354
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO 3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FTH1 protein]]; 3-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FTH1 protein]; 3-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FTH1 protein] CTD PMID:36435477 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of GPT protein] CTD PMID:31332890 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO 3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GPX4 protein]]; 3-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GPX4 protein]; 3-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GPX4 protein] CTD PMID:36435477 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629
JBrowse link
G Hcar2 hydroxycarboxylic acid receptor 2 increases activity
multiple interactions
ISO 3-Hydroxybutyric Acid results in increased activity of HCAR2 protein
3-Hydroxybutyric Acid binds to and results in increased activity of HCAR2 protein; [3-Hydroxybutyric Acid results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]
CTD PMID:15929991 PMID:19223991 NCBI chr12:38,387,163...38,389,149
Ensembl chr12:38,387,230...38,389,391
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases secretion ISO HMGCS2 protein results in increased secretion of 3-Hydroxybutyric Acid CTD PMID:27816970 NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242
JBrowse link
G Il25 interleukin 25 multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [3-(indol-3-yl)propionic acid results in increased secretion of IL25 protein] CTD PMID:35509122 NCBI chr15:32,378,750...32,382,141
Ensembl chr15:32,378,750...32,382,141
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of IL6 protein] CTD PMID:31332890 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [NFE2L2 protein mutant form co-treated with Streptozocin] results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:20086057 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:20404010 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] CTD PMID:25440059 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
JBrowse link
G Slc13a5 solute carrier family 13 member 5 decreases abundance ISO SLC13A5 protein results in decreased abundance of 3-Hydroxybutyric Acid CTD PMID:32634519 NCBI chr10:57,364,806...57,389,500
Ensembl chr10:57,364,806...57,389,516
JBrowse link
G Snca synuclein alpha multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]; 3-Hydroxybutyric Acid promotes the reaction [ursodoxicoltaurine inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]]
3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein]]; 3-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein]; 3-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein]
CTD PMID:16239214 PMID:36435477 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO 3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]]; 3-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]; 3-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:36435477 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of TNF protein] CTD PMID:31332890 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased acetylation of TP53 protein] CTD PMID:25440059 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of UCP2 protein] CTD PMID:25440059 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743
JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions ISO 3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FTH1 protein]]; 3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GPX4 protein]]; 3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]]; 3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ACSL4 protein]]; 3-Hydroxybutyric Acid affects the reaction [ZFP36 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein]]; 3-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of ZFP36 mRNA]; 3-Hydroxybutyric Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of ZFP36 protein] CTD PMID:36435477 NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:92,796,628...92,799,108
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20841
    chemical entity 20839
      atom 20839
        nonmetal atom 20747
          carbon atom 20690
            organic molecular entity 20690
              lipid 18227
                fatty acid 16980
                  hydroxy fatty acid 212
                    (omega-1)-hydroxy fatty acid 26
                      (10R)-10-hydroxyundecanoic acid + 0
                      (12R)-12-hydroxytridecanoic acid + 0
                      (13R)-13-hydroxymyristic acid + 0
                      (14R)-14-hydroxypentadecanoic acid + 0
                      (16R)-16-hydroxymargaric acid + 0
                      (18R)-18-hydroxynonadecanoic acid + 0
                      (19R)-19-hydroxyicosanoic acid + 0
                      (2E,10R)-10-hydroxyundec-2-enoic acid + 0
                      (2E,11R)-11-hydroxydodec-2-enoic acid + 0
                      (2E,12R)-12-hydroxytridec-2-enoic acid + 0
                      (2E,13R)-13-hydroxytetradec-2-enoic acid + 0
                      (2E,14R)-14-hydroxypentadec-2-enoic acid + 0
                      (2E,15R)-15-hydroxyhexadec-2-enoic acid + 0
                      (2E,16R)-16-hydroxyheptadec-2-enoic acid + 0
                      (2E,17R)-17-hydroxyoctadec-2-enoic acid + 0
                      (2E,18R)-18-hydroxynonadec-2-enoic acid + 0
                      (2E,19R)-19-hydroxyicos-2-enoic acid + 0
                      (2E,20R)-20-hydroxyhenicos-2-enoic acid + 0
                      (2E,6R)-6-hydroxyhept-2-enoic acid + 0
                      (2E,7R)-7-hydroxyoct-2-enoic acid + 0
                      (2E,8R)-8-hydroxynon-2-enoic acid + 0
                      (2E,9R)-9-hydroxydec-2-enoic acid + 0
                      (3R,10R)-3,10-dihydroxyundecanoic acid + 0
                      (3R,11R)-3,11-dihydroxylauric acid + 0
                      (3R,12R)-3,12-dihydroxytridecanoic acid + 0
                      (3R,13R)-3,13-dihydroxymyristic acid + 0
                      (3R,14R)-3,14-dihydroxypentadecanoic acid + 0
                      (3R,15R)-3,15-dihydroxypalmitic acid + 0
                      (3R,16R)-3,16-dihydroxymargaric acid + 0
                      (3R,18R)-3,18-dihydroxynonadecanoic acid + 0
                      (3R,19R)-19-dihydroxyicosanoic acid + 0
                      (3R,20R)-3,20-dihydroxyhenicosanoic acid + 0
                      (3R,21R)-3,21-dihydroxybehenic acid + 0
                      (3R,22R)-3,22-dihydroxytricosanoic acid + 0
                      (3R,8R)-3,8-dihydroxynonanoic acid + 0
                      (3R,9R)-3,9-dihydroxydecanoic acid + 0
                      (4R)-4-hydroxypentanoic acid + 0
                      (5R)-5-hydroxyhexanoic acid + 0
                      (7R)-7-hydroxyoctanoic acid + 0
                      (8R)-8-hydroxynonanoic acid + 0
                      (9R)-9-hydroxydecanoic acid + 0
                      (9Z)-17-hydroxyoctadec-9-enoic acid + 0
                      (9Z,12Z)-17-hydroxyoctadeca-9,12-dienoic acid 0
                      (R)-17-hydroxyoctadecanoic acid + 0
                      (R,R)-3,17-dihydroxyoctadecanoic acid + 0
                      (omega-1)-hydroxy fatty acid ascaroside + 0
                      11-hydroxylauric acid + 0
                      13-hydroxytetradecanoic acid 0
                      15-hydroxypalmitic acid + 0
                      17-Hydroxylinolenic acid 0
                      17-hydroxy-linolenic acid 0
                      19-HETrE 0
                      19-hydroxyicosanoic acid 0
                      20-hydroxyhenicosanoic acid + 0
                      21-HDoHE 0
                      3-hydroxybutyric acid + 26
                      5-hydroxyhexanoic acid 0
                      6-hydroxyheptanoic acid + 0
                      9,10-epoxy-17-hydroxyoctadecanoic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20841
    subatomic particle 20839
      composite particle 20839
        hadron 20839
          baryon 20839
            nucleon 20839
              atomic nucleus 20839
                atom 20839
                  main group element atom 20762
                    p-block element atom 20786
                      carbon group element atom 20695
                        carbon atom 20690
                          organic molecular entity 20690
                            heteroorganic entity 20202
                              organochalcogen compound 19889
                                organooxygen compound 19791
                                  carbon oxoacid 19142
                                    carboxylic acid 19139
                                      monocarboxylic acid 18291
                                        fatty acid 16980
                                          hydroxy fatty acid 212
                                            (omega-1)-hydroxy fatty acid 26
                                              (10R)-10-hydroxyundecanoic acid + 0
                                              (12R)-12-hydroxytridecanoic acid + 0
                                              (13R)-13-hydroxymyristic acid + 0
                                              (14R)-14-hydroxypentadecanoic acid + 0
                                              (16R)-16-hydroxymargaric acid + 0
                                              (18R)-18-hydroxynonadecanoic acid + 0
                                              (19R)-19-hydroxyicosanoic acid + 0
                                              (2E,10R)-10-hydroxyundec-2-enoic acid + 0
                                              (2E,11R)-11-hydroxydodec-2-enoic acid + 0
                                              (2E,12R)-12-hydroxytridec-2-enoic acid + 0
                                              (2E,13R)-13-hydroxytetradec-2-enoic acid + 0
                                              (2E,14R)-14-hydroxypentadec-2-enoic acid + 0
                                              (2E,15R)-15-hydroxyhexadec-2-enoic acid + 0
                                              (2E,16R)-16-hydroxyheptadec-2-enoic acid + 0
                                              (2E,17R)-17-hydroxyoctadec-2-enoic acid + 0
                                              (2E,18R)-18-hydroxynonadec-2-enoic acid + 0
                                              (2E,19R)-19-hydroxyicos-2-enoic acid + 0
                                              (2E,20R)-20-hydroxyhenicos-2-enoic acid + 0
                                              (2E,6R)-6-hydroxyhept-2-enoic acid + 0
                                              (2E,7R)-7-hydroxyoct-2-enoic acid + 0
                                              (2E,8R)-8-hydroxynon-2-enoic acid + 0
                                              (2E,9R)-9-hydroxydec-2-enoic acid + 0
                                              (3R,10R)-3,10-dihydroxyundecanoic acid + 0
                                              (3R,11R)-3,11-dihydroxylauric acid + 0
                                              (3R,12R)-3,12-dihydroxytridecanoic acid + 0
                                              (3R,13R)-3,13-dihydroxymyristic acid + 0
                                              (3R,14R)-3,14-dihydroxypentadecanoic acid + 0
                                              (3R,15R)-3,15-dihydroxypalmitic acid + 0
                                              (3R,16R)-3,16-dihydroxymargaric acid + 0
                                              (3R,18R)-3,18-dihydroxynonadecanoic acid + 0
                                              (3R,19R)-19-dihydroxyicosanoic acid + 0
                                              (3R,20R)-3,20-dihydroxyhenicosanoic acid + 0
                                              (3R,21R)-3,21-dihydroxybehenic acid + 0
                                              (3R,22R)-3,22-dihydroxytricosanoic acid + 0
                                              (3R,8R)-3,8-dihydroxynonanoic acid + 0
                                              (3R,9R)-3,9-dihydroxydecanoic acid + 0
                                              (4R)-4-hydroxypentanoic acid + 0
                                              (5R)-5-hydroxyhexanoic acid + 0
                                              (7R)-7-hydroxyoctanoic acid + 0
                                              (8R)-8-hydroxynonanoic acid + 0
                                              (9R)-9-hydroxydecanoic acid + 0
                                              (9Z)-17-hydroxyoctadec-9-enoic acid + 0
                                              (9Z,12Z)-17-hydroxyoctadeca-9,12-dienoic acid 0
                                              (R)-17-hydroxyoctadecanoic acid + 0
                                              (R,R)-3,17-dihydroxyoctadecanoic acid + 0
                                              (omega-1)-hydroxy fatty acid ascaroside + 0
                                              11-hydroxylauric acid + 0
                                              13-hydroxytetradecanoic acid 0
                                              15-hydroxypalmitic acid + 0
                                              17-Hydroxylinolenic acid 0
                                              17-hydroxy-linolenic acid 0
                                              19-HETrE 0
                                              19-hydroxyicosanoic acid 0
                                              20-hydroxyhenicosanoic acid + 0
                                              21-HDoHE 0
                                              3-hydroxybutyric acid + 26
                                              5-hydroxyhexanoic acid 0
                                              6-hydroxyheptanoic acid + 0
                                              9,10-epoxy-17-hydroxyoctadecanoic acid 0
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