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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(omega-1)-hydroxy fatty acid
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Accession:CHEBI:78954 term browser browse the term
Definition:A hydroxy fatty acid that is a straight-chain fatty acid in which one of the hydrogens attached to the carbon adjacent to the terminal methyl group (i.e. at the (omega-1) position) is replaced by a hydroxy group.
Synonyms:related_synonym: (omega-1)-hydroxy fatty acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:84497


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3-hydroxybutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp9 aquaporin 9 increases uptake EXP AQP9 protein results in increased uptake of 3-Hydroxybutyric Acid CTD PMID:9733774 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781
JBrowse link
G Atg5 autophagy related 5 increases abundance ISO ATG5 protein results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:25943029 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Becn1 beclin 1 increases abundance ISO BECN1 protein results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:25943029 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [Rotenone results in increased activity of CASP3 protein]
3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of CASP3 protein]
CTD PMID:16917840, PMID:31332890 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of CASP8 protein] CTD PMID:31332890 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [Rotenone results in increased activity of CASP9 protein]
3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of CASP9 protein]
CTD PMID:16917840, PMID:31332890 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor multiple interactions
decreases abundance
ISO 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of UCP2 protein]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased acetylation of TP53 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]]
Dietary Fats inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of 3-Hydroxybutyric Acid]
CTD PMID:25440059 NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of GPT protein] CTD PMID:31332890 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hcar2 hydroxycarboxylic acid receptor 2 increases activity
multiple interactions
ISO 3-Hydroxybutyric Acid results in increased activity of HCAR2 protein
3-Hydroxybutyric Acid binds to and results in increased activity of HCAR2 protein; [3-Hydroxybutyric Acid results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]
CTD PMID:15929991, PMID:19223991 NCBI chr12:38,160,464...38,161,546
Ensembl chr12:38,160,464...38,161,546
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases secretion ISO HMGCS2 protein results in increased secretion of 3-Hydroxybutyric Acid CTD PMID:27816970 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of IL6 protein] CTD PMID:31332890 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [NFE2L2 protein mutant form co-treated with Streptozocin] results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:20086057 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of 3-Hydroxybutyric Acid CTD PMID:20404010 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] CTD PMID:25440059 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc13a5 solute carrier family 13 member 5 decreases abundance ISO SLC13A5 protein results in decreased abundance of 3-Hydroxybutyric Acid CTD PMID:32634519 NCBI chr10:58,806,581...58,835,549
Ensembl chr10:58,810,058...58,834,538
JBrowse link
G Snca synuclein alpha multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]; 3-Hydroxybutyric Acid promotes the reaction [tauroursodeoxycholic acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]] CTD PMID:16239214 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 3-Hydroxybutyric Acid promotes the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of TNF protein] CTD PMID:31332890 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased acetylation of TP53 protein] CTD PMID:25440059 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of UCP2 protein] CTD PMID:25440059 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          carbon atom 19597
            organic molecular entity 19597
              lipid 17059
                fatty acid 15990
                  hydroxy fatty acid 186
                    (omega-1)-hydroxy fatty acid 19
                      (10R)-10-hydroxyundecanoic acid + 0
                      (12R)-12-hydroxytridecanoic acid + 0
                      (13R)-13-hydroxymyristic acid + 0
                      (14R)-14-hydroxypentadecanoic acid + 0
                      (15R)-15-hydroxypalmitic acid + 0
                      (16R)-16-hydroxymargaric acid + 0
                      (18R)-18-hydroxynonadecanoic acid + 0
                      (19R)-19-hydroxyicosanoic acid + 0
                      (2E,10R)-10-hydroxyundec-2-enoic acid + 0
                      (2E,11R)-11-hydroxydodec-2-enoic acid + 0
                      (2E,12R)-12-hydroxytridec-2-enoic acid + 0
                      (2E,13R)-13-hydroxytetradec-2-enoic acid + 0
                      (2E,14R)-14-hydroxypentadec-2-enoic acid + 0
                      (2E,15R)-15-hydroxyhexadec-2-enoic acid + 0
                      (2E,16R)-16-hydroxyheptadec-2-enoic acid + 0
                      (2E,17R)-17-hydroxyoctadec-2-enoic acid + 0
                      (2E,18R)-18-hydroxynonadec-2-enoic acid + 0
                      (2E,19R)-19-hydroxyicos-2-enoic acid + 0
                      (2E,20R)-20-hydroxyhenicos-2-enoic acid + 0
                      (2E,6R)-6-hydroxyhept-2-enoic acid + 0
                      (2E,7R)-7-hydroxyoct-2-enoic acid + 0
                      (2E,8R)-8-hydroxynon-2-enoic acid + 0
                      (2E,9R)-9-hydroxydec-2-enoic acid + 0
                      (3R,10R)-3,10-dihydroxyundecanoic acid + 0
                      (3R,11R)-3,11-dihydroxylauric acid + 0
                      (3R,12R)-3,12-dihydroxytridecanoic acid + 0
                      (3R,13R)-3,13-dihydroxymyristic acid + 0
                      (3R,14R)-3,14-dihydroxypentadecanoic acid + 0
                      (3R,15R)-3,15-dihydroxypalmitic acid + 0
                      (3R,16R)-3,16-dihydroxymargaric acid + 0
                      (3R,18R)-3,18-dihydroxynonadecanoic acid + 0
                      (3R,19R)-19-dihydroxyicosanoic acid + 0
                      (3R,20R)-3,20-dihydroxyhenicosanoic acid + 0
                      (3R,21R)-3,21-dihydroxybehenic acid + 0
                      (3R,22R)-3,22-dihydroxytricosanoic acid + 0
                      (3R,8R)-3,8-dihydroxynonanoic acid + 0
                      (3R,9R)-3,9-dihydroxydecanoic acid + 0
                      (4R)-4-hydroxypentanoic acid + 0
                      (5R)-5-hydroxyhexanoic acid + 0
                      (7R)-7-hydroxyoctanoic acid + 0
                      (8R)-8-hydroxynonanoic acid + 0
                      (9R)-9-hydroxydecanoic acid + 0
                      (9Z)-17-hydroxyoctadec-9-enoic acid + 0
                      (9Z)-17-hydroxyoctadec-9-enoic acid 17-O-sophoroside 0
                      (9Z,12Z)-17-hydroxyoctadeca-9,12-dienoic acid 0
                      (R)-17-hydroxyoctadecanoic acid + 0
                      (R,R)-3,17-dihydroxyoctadecanoic acid + 0
                      (omega-1)-hydroxy fatty acid ascaroside + 0
                      11-hydroxylauric acid + 0
                      13-hydroxytetradecanoic acid 0
                      19-HETrE 0
                      19-hydroxyicosanoic acid 0
                      20-hydroxyhenicosanoic acid + 0
                      21-HDoHE 0
                      3-hydroxybutyric acid + 19
                      5-hydroxyhexanoic acid 0
                      6-hydroxyheptanoic acid + 0
                      9,10-epoxy-17-hydroxyoctadecanoic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        monocarboxylic acid 17476
                                          fatty acid 15990
                                            hydroxy fatty acid 186
                                              (omega-1)-hydroxy fatty acid 19
                                                (10R)-10-hydroxyundecanoic acid + 0
                                                (12R)-12-hydroxytridecanoic acid + 0
                                                (13R)-13-hydroxymyristic acid + 0
                                                (14R)-14-hydroxypentadecanoic acid + 0
                                                (15R)-15-hydroxypalmitic acid + 0
                                                (16R)-16-hydroxymargaric acid + 0
                                                (18R)-18-hydroxynonadecanoic acid + 0
                                                (19R)-19-hydroxyicosanoic acid + 0
                                                (2E,10R)-10-hydroxyundec-2-enoic acid + 0
                                                (2E,11R)-11-hydroxydodec-2-enoic acid + 0
                                                (2E,12R)-12-hydroxytridec-2-enoic acid + 0
                                                (2E,13R)-13-hydroxytetradec-2-enoic acid + 0
                                                (2E,14R)-14-hydroxypentadec-2-enoic acid + 0
                                                (2E,15R)-15-hydroxyhexadec-2-enoic acid + 0
                                                (2E,16R)-16-hydroxyheptadec-2-enoic acid + 0
                                                (2E,17R)-17-hydroxyoctadec-2-enoic acid + 0
                                                (2E,18R)-18-hydroxynonadec-2-enoic acid + 0
                                                (2E,19R)-19-hydroxyicos-2-enoic acid + 0
                                                (2E,20R)-20-hydroxyhenicos-2-enoic acid + 0
                                                (2E,6R)-6-hydroxyhept-2-enoic acid + 0
                                                (2E,7R)-7-hydroxyoct-2-enoic acid + 0
                                                (2E,8R)-8-hydroxynon-2-enoic acid + 0
                                                (2E,9R)-9-hydroxydec-2-enoic acid + 0
                                                (3R,10R)-3,10-dihydroxyundecanoic acid + 0
                                                (3R,11R)-3,11-dihydroxylauric acid + 0
                                                (3R,12R)-3,12-dihydroxytridecanoic acid + 0
                                                (3R,13R)-3,13-dihydroxymyristic acid + 0
                                                (3R,14R)-3,14-dihydroxypentadecanoic acid + 0
                                                (3R,15R)-3,15-dihydroxypalmitic acid + 0
                                                (3R,16R)-3,16-dihydroxymargaric acid + 0
                                                (3R,18R)-3,18-dihydroxynonadecanoic acid + 0
                                                (3R,19R)-19-dihydroxyicosanoic acid + 0
                                                (3R,20R)-3,20-dihydroxyhenicosanoic acid + 0
                                                (3R,21R)-3,21-dihydroxybehenic acid + 0
                                                (3R,22R)-3,22-dihydroxytricosanoic acid + 0
                                                (3R,8R)-3,8-dihydroxynonanoic acid + 0
                                                (3R,9R)-3,9-dihydroxydecanoic acid + 0
                                                (4R)-4-hydroxypentanoic acid + 0
                                                (5R)-5-hydroxyhexanoic acid + 0
                                                (7R)-7-hydroxyoctanoic acid + 0
                                                (8R)-8-hydroxynonanoic acid + 0
                                                (9R)-9-hydroxydecanoic acid + 0
                                                (9Z)-17-hydroxyoctadec-9-enoic acid + 0
                                                (9Z)-17-hydroxyoctadec-9-enoic acid 17-O-sophoroside 0
                                                (9Z,12Z)-17-hydroxyoctadeca-9,12-dienoic acid 0
                                                (R)-17-hydroxyoctadecanoic acid + 0
                                                (R,R)-3,17-dihydroxyoctadecanoic acid + 0
                                                (omega-1)-hydroxy fatty acid ascaroside + 0
                                                11-hydroxylauric acid + 0
                                                13-hydroxytetradecanoic acid 0
                                                19-HETrE 0
                                                19-hydroxyicosanoic acid 0
                                                20-hydroxyhenicosanoic acid + 0
                                                21-HDoHE 0
                                                3-hydroxybutyric acid + 19
                                                5-hydroxyhexanoic acid 0
                                                6-hydroxyheptanoic acid + 0
                                                9,10-epoxy-17-hydroxyoctadecanoic acid 0
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