Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tirapazamine
go back to main search page
Accession:CHEBI:78887 term browser browse the term
Definition:A member of the class of benzotriazines that is 1,2,4-benzotriazine carrying an amino substituent at position 3 and two oxido substituents at positions 1 and 4.
Synonyms:exact_synonym: 1,2,4-benzotriazin-3-amine 1,4-dioxide
 related_synonym: 3-Amino-1,2,4-benzotriazine 1,4-dioxide;   Formula=C7H6N4O2;   InChI=1S/C7H6N4O2/c8-7-9-11(13)6-4-2-1-3-5(6)10(7)12/h1-4H,(H2,8,9);   InChIKey=ORYDPOVDJJZGHQ-UHFFFAOYSA-N;   SMILES=Nc1n[n+]([O-])c2ccccc2[n+]1[O-];   SR 4233
 xref: Beilstein:179322;   CAS:27314-97-2;   KEGG:D06167
 xref_mesh: MESH:C049947
 xref: PMID:22331808;   PMID:22531857;   PMID:22666522;   PMID:22946564;   PMID:23033890;   PMID:23888874;   PMID:24362462;   PMID:24395863;   PMID:24529061;   PMID:7954337;   Reaxys:179322;   Wikipedia:Tirapazamine


show annotations for term's descendants           Sort by:
 
tirapazamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP CAT protein inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO tirapazamine results in increased expression of CDKN1A CTD PMID:15814660 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to tirapazamine] CTD PMID:10919648 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP 1-phenylimidazole inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; 2-Propanol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; CAT protein inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; CYP2E1 protein results in increased reduction of and results in increased activity of and results in increased susceptibility to tirapazamine; Deferoxamine inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Dicumarol promotes the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Ethanol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Isoniazid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; purpurogallin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Quercetin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; tempol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to tirapazamine] CTD PMID:10919648 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Tp53 tumor protein p53 increases expression
increases response to substance
ISO tirapazamine results in increased expression of TP53
TRP53 protein mutant form results in increased susceptibility to tirapazamine
TP53 results in increased susceptibility to tirapazamine
CTD PMID:15814660, PMID:16012721 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          antibacterial agent 13019
            tirapazamine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterobicyclic compound 16742
                                      mancude organic heterobicyclic parent 5189
                                        benzotriazine 13
                                          1,2,4-benzotriazine 7
                                            tirapazamine 6
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.