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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tirapazamine
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Accession:CHEBI:78887 term browser browse the term
Definition:A member of the class of benzotriazines that is 1,2,4-benzotriazine carrying an amino substituent at position 3 and two oxido substituents at positions 1 and 4.
Synonyms:exact_synonym: 1,2,4-benzotriazin-3-amine 1,4-dioxide
 related_synonym: 3-Amino-1,2,4-benzotriazine 1,4-dioxide;   Formula=C7H6N4O2;   InChI=1S/C7H6N4O2/c8-7-9-11(13)6-4-2-1-3-5(6)10(7)12/h1-4H,(H2,8,9);   InChIKey=ORYDPOVDJJZGHQ-UHFFFAOYSA-N;   SMILES=Nc1n[n+]([O-])c2ccccc2[n+]1[O-];   SR 4233
 xref: Beilstein:179322;   CAS:27314-97-2;   KEGG:D06167
 xref_mesh: MESH:C049947
 xref: PMID:22331808;   PMID:22531857;   PMID:22666522;   PMID:22946564;   PMID:23033890;   PMID:23888874;   PMID:24362462;   PMID:24395863;   PMID:24529061;   PMID:7954337;   Reaxys:179322;   Wikipedia:Tirapazamine



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tirapazamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP CAT protein inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO tirapazamine results in increased expression of CDKN1A CTD PMID:15814660 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to tirapazamine] CTD PMID:10919648 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP 1-phenylimidazole inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; 2-Propanol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; CAT protein inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; CYP2E1 protein results in increased reduction of and results in increased activity of and results in increased susceptibility to tirapazamine; Deferoxamine inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Dicumarol promotes the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Ethanol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Isoniazid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; purpurogallin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Quercetin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; tempol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to tirapazamine] CTD PMID:10919648 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Tp53 tumor protein p53 increases expression
increases response to substance
ISO tirapazamine results in increased expression of TP53
TRP53 protein mutant form results in increased susceptibility to tirapazamine
TP53 results in increased susceptibility to tirapazamine
CTD PMID:15814660 PMID:16012721 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        antimicrobial agent 17818
          antibacterial agent 14324
            tirapazamine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  organic heteropolycyclic compound 18298
                                    organic heterobicyclic compound 17170
                                      mancude organic heterobicyclic parent 5441
                                        benzotriazine 15
                                          1,2,4-benzotriazine 7
                                            tirapazamine 6
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