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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tirapazamine
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Accession:CHEBI:78887 term browser browse the term
Definition:A member of the class of benzotriazines that is 1,2,4-benzotriazine carrying an amino substituent at position 3 and two oxido substituents at positions 1 and 4.
Synonyms:exact_synonym: 1,2,4-benzotriazin-3-amine 1,4-dioxide
 related_synonym: 3-Amino-1,2,4-benzotriazine 1,4-dioxide;   Formula=C7H6N4O2;   InChI=1S/C7H6N4O2/c8-7-9-11(13)6-4-2-1-3-5(6)10(7)12/h1-4H,(H2,8,9);   InChIKey=ORYDPOVDJJZGHQ-UHFFFAOYSA-N;   SMILES=Nc1n[n+]([O-])c2ccccc2[n+]1[O-];   SR 4233
 xref: Beilstein:179322;   CAS:27314-97-2;   KEGG:D06167
 xref_mesh: MESH:C049947
 xref: PMID:22331808;   PMID:22531857;   PMID:22666522;   PMID:22946564;   PMID:23033890;   PMID:23888874;   PMID:24362462;   PMID:24395863;   PMID:24529061;   PMID:7954337;   Reaxys:179322;   Wikipedia:Tirapazamine


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tirapazamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP CAT protein inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO tirapazamine results in increased expression of CDKN1A CTD PMID:15814660 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to tirapazamine] CTD PMID:10919648 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP 1-phenylimidazole inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; 2-Propanol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; CAT protein inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; CYP2E1 protein results in increased reduction of and results in increased activity of and results in increased susceptibility to tirapazamine; Deferoxamine inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Dicumarol promotes the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Ethanol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Isoniazid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; purpurogallin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Quercetin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; tempol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to tirapazamine] CTD PMID:10919648 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Tp53 tumor protein p53 increases expression
increases response to substance
ISO tirapazamine results in increased expression of TP53
TRP53 protein mutant form results in increased susceptibility to tirapazamine
TP53 results in increased susceptibility to tirapazamine
CTD PMID:15814660 PMID:16012721 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          antibacterial agent 13566
            tirapazamine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteropolycyclic compound 18059
                                    organic heterobicyclic compound 16869
                                      mancude organic heterobicyclic parent 5409
                                        benzotriazine 15
                                          1,2,4-benzotriazine 7
                                            tirapazamine 6
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