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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-terpineol
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Accession:CHEBI:78884 term browser browse the term
Definition:A terpineol that is 1-menthene carrying a hydroxy substituent at position 4.
Synonyms:exact_synonym: 4-methyl-1-(propan-2-yl)cyclohex-3-en-1-ol
 related_synonym: 1-Menthene-4-ol;   1-Methyl-4-isopropyl-1-cyclohexen-4-ol;   1-Terpinen-4-ol;   1-isopropyl-4-methylcyclohex-3-en-1-ol;   1-p-Menthen-4-ol;   1-para-Menthen-4-ol;   4-Carvomenthenol;   4-Methyl-1-(1-methylethyl)-3-cyclohexen-1-ol;   4-Methyl-1-isopropyl-3-cyclohexen-1-ol;   Formula=C10H18O;   InChI=1S/C10H18O/c1-8(2)10(11)6-4-9(3)5-7-10/h4,8,11H,5-7H2,1-3H3;   InChIKey=WRYLYDPHFGVWKC-UHFFFAOYSA-N;   SMILES=CC(C)C1(O)CCC(C)=CC1;   Terpene-4-ol;   Terpin-4-en-1-ol;   Terpinen-4-ol;   Terpinene-4-ol;   Terpinenol-4;   alpha-terpinen-4-ol;   p-Menth-1-en-4-ol
 alt_id: CHEBI:132655
 xref: BPDB:2012;   CAS:562-74-3;   HMDB:HMDB0035833;   KEGG:C17073
 xref_mesh: MESH:C034019
 xref: PMID:21760828;   PMID:22998411;   PMID:23292030;   PMID:23469686;   PMID:23649340;   PMID:24349880;   PMID:24460330;   PMID:24731375;   Pubchem:11230;   Reaxys:1906603



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4-terpineol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsd cathepsin D increases expression
multiple interactions
ISO terpinenol-4 results in increased expression of CTSD mRNA
Fulvestrant inhibits the reaction [terpinenol-4 results in increased expression of CTSD mRNA]
CTD PMID:31393563 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 multiple interactions ISO terpinenol-4 inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA] CTD PMID:31393563 NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782
JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions
ISO terpinenol-4 results in increased activity of ESR1 protein
NCOA2 protein promotes the reaction [terpinenol-4 results in increased activity of ESR1 protein]
CTD PMID:31393563 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 increases expression
multiple interactions
ISO terpinenol-4 results in increased expression of GREB1 mRNA
Fulvestrant inhibits the reaction [terpinenol-4 results in increased expression of GREB1 mRNA]
CTD PMID:31393563 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO NCOA2 protein promotes the reaction [terpinenol-4 results in increased activity of ESR1 protein] CTD PMID:31393563 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [terpinenol-4 results in increased expression of PGR mRNA] CTD PMID:31393563 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G RGD1559459 similar to Expressed sequence AI788959 multiple interactions ISO terpinenol-4 inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA] CTD PMID:31393563 NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704
JBrowse link
G Sec14l2 SEC14-like lipid binding 2 multiple interactions ISO terpinenol-4 inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] CTD PMID:31393563 NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788
JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of terpinenol-4 CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
JBrowse link
tea tree oil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased activity of AR protein] CTD PMID:31393563 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of CTSD mRNA] CTD PMID:31393563 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA] CTD PMID:31393563 NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Tea Tree Oil results in increased activity of ESR1 protein CTD PMID:31393563 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of GREB1 mRNA] CTD PMID:31393563 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
ISO Tea Tree Oil results in increased expression of PGR mRNA
Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of PGR mRNA]
CTD PMID:31393563 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G RGD1559459 similar to Expressed sequence AI788959 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA] CTD PMID:31393563 NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704
JBrowse link
G Sec14l2 SEC14-like lipid binding 2 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] CTD PMID:31393563 NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      chemical role 19356
        antioxidant 15686
          4-terpineol 10
            tea tree oil 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    main group molecular entity 19686
                      s-block molecular entity 19541
                        hydrogen molecular entity 19534
                          hydrides 19019
                            organic hydride 18632
                              organic fundamental parent 18632
                                hydrocarbon 18375
                                  terpene 13703
                                    terpenoid 13378
                                      monoterpenoid 1239
                                        p-menthane monoterpenoid 441
                                          terpineol 10
                                            4-terpineol 10
                                              tea tree oil 8
paths to the root