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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sodium nitrite
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Accession:CHEBI:78870 term browser browse the term
Definition:An inorganic sodium salt having nitrite as the counterion. Used as a food preservative and antidote to cyanide poisoning.
Synonyms:related_synonym: Formula=NNaO2;   InChI=1S/HNO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1;   InChIKey=LPXPTNMVRIOKMN-UHFFFAOYSA-M;   NaNO2;   Natrium nitrit;   Nitrite de sodium;   Nitrito sodico;   SMILES=[Na+].[O-]N=O
 xref: CAS:7632-00-0;   KEGG:D05865
 xref_mesh: MESH:D012977
 xref: PMID:24200576;   PMID:24266433;   PMID:24333935;   PMID:24363302;   PMID:24535441;   PMID:24639423;   PMID:24658348;   PMID:24834717;   PMID:24861891;   PMID:24878382;   PMID:24898570;   PMID:24929713;   Reaxys:906771;   Wikipedia:Sodium_nitrite



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sodium nitrite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO [Hypochlorous Acid co-treated with Sodium Nitrite] results in decreased activity of ACHE protein
Sodium Nitrite results in decreased activity of ACHE protein
CTD PMID:12414318 PMID:26231821 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acp1 acid phosphatase 1 increases activity ISO Sodium Nitrite results in increased activity of ACP1 protein CTD PMID:26231821 NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of AKT1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of AKT1 protein]
CTD PMID:28266762 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases activity ISO Sodium Nitrite results in increased activity of AMPD3 protein CTD PMID:26231821 NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme] CTD PMID:25211009 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of BAX mRNA; Sodium Nitrite results in increased expression of BAX protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]
CTD PMID:28000380 PMID:28266762 PMID:28833918 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP Sodium Nitrite results in decreased expression of BCL2 mRNA; Sodium Nitrite results in decreased expression of BCL2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]
CTD PMID:28000380 PMID:28266762 PMID:28833918 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP Sodium Nitrite results in increased activity of CASP3 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of CASP3 protein]
CTD PMID:28833918 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases activity
increases activity
ISO Sodium Nitrite results in decreased activity of CAT protein
Sodium Nitrite results in increased activity of CAT protein
CTD PMID:26231821 PMID:31476334 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Sodium Nitrite results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Sodium Nitrite results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Crp C-reactive protein multiple interactions
increases expression
EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of CRP protein] CTD PMID:28266762 PMID:28833918 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO Sodium Nitrite results in decreased activity of G6PD protein CTD PMID:26231821 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of GPT protein] CTD PMID:28833918 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO Sodium Nitrite results in decreased activity of GSR protein CTD PMID:26231821 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Sodium Nitrite results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of HIF1A protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]
CTD PMID:28000380 PMID:28266762 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
ISO Sodium Nitrite results in increased expression of IL1B mRNA
Sodium Nitrite results in increased secretion of IL1B protein
CTD PMID:16581224 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Sodium Nitrite results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
multiple interactions
ISO
EXP
Sodium Nitrite results in increased secretion of IL6 protein
Sodium Nitrite results in increased expression of IL6 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of IL6 protein]
CTD PMID:16581224 PMID:28266762 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ldhb lactate dehydrogenase B increases activity ISO Sodium Nitrite results in increased activity of LDHB protein CTD PMID:26231821 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Sodium Nitrite results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression
EXP Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of NFKBIA mRNA] CTD PMID:28833918 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Sodium Nitrite results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,759,454...159,772,524
Ensembl chr 4:159,759,459...159,772,524
JBrowse link
G Smad2 SMAD family member 2 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of SMAD2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]
CTD PMID:28000380 PMID:28266762 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Stmn1 stathmin 1 increases expression ISO Sodium Nitrite results in increased expression of STMN1 protein CTD PMID:20025956 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of TGFB1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein]
CTD PMID:28266762 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion
ISO
EXP
Sodium Nitrite results in increased expression of TNF mRNA
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]
Sodium Nitrite results in increased secretion of TNF protein
CTD PMID:16581224 PMID:28266762 PMID:28833918 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of VEGFA protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of VEGFA protein]
CTD PMID:28266762 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        poison 18294
          sodium nitrite 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      chalcogen 19450
                        oxygen atom 19423
                          oxygen molecular entity 19423
                            hydroxides 19158
                              oxoacid 18472
                                pnictogen oxoacid 10733
                                  nitrogen oxoacid 276
                                    nitrous acid 58
                                      nitrites 58
                                        nitrite salt 29
                                          sodium nitrite 29
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