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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sodium nitrite
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Accession:CHEBI:78870 term browser browse the term
Definition:An inorganic sodium salt having nitrite as the counterion. Used as a food preservative and antidote to cyanide poisoning.
Synonyms:related_synonym: Formula=NNaO2;   InChI=1S/HNO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1;   InChIKey=LPXPTNMVRIOKMN-UHFFFAOYSA-M;   NaNO2;   Natrium nitrit;   Nitrite de sodium;   Nitrito sodico;   SMILES=[Na+].[O-]N=O
 xref: CAS:7632-00-0;   KEGG:D05865
 xref_mesh: MESH:D012977
 xref: PMID:24200576;   PMID:24266433;   PMID:24333935;   PMID:24363302;   PMID:24535441;   PMID:24639423;   PMID:24658348;   PMID:24834717;   PMID:24861891;   PMID:24878382;   PMID:24898570;   PMID:24929713;   Reaxys:906771;   Wikipedia:Sodium_nitrite


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sodium nitrite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity		 ISO [Hypochlorous Acid co-treated with Sodium Nitrite] results in decreased activity of ACHE protein
Sodium Nitrite results in decreased activity of ACHE protein		 CTD PMID:12414318 PMID:26231821 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acp1 acid phosphatase 1 increases activity ISO Sodium Nitrite results in increased activity of ACP1 protein CTD PMID:26231821 NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions		 EXP Sodium Nitrite results in increased expression of AKT1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of AKT1 protein]		 CTD PMID:28266762 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases activity ISO Sodium Nitrite results in increased activity of AMPD3 protein CTD PMID:26231821 NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme] CTD PMID:25211009 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP Sodium Nitrite results in increased expression of BAX mRNA; Sodium Nitrite results in increased expression of BAX protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]		 CTD PMID:28000380 PMID:28266762 PMID:28833918 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 EXP Sodium Nitrite results in decreased expression of BCL2 mRNA; Sodium Nitrite results in decreased expression of BCL2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]		 CTD PMID:28000380 PMID:28266762 PMID:28833918 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 EXP Sodium Nitrite results in increased activity of CASP3 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of CASP3 protein]		 CTD PMID:28833918 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases activity
increases activity		 ISO Sodium Nitrite results in decreased activity of CAT protein
Sodium Nitrite results in increased activity of CAT protein		 CTD PMID:26231821 PMID:31476334 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Sodium Nitrite results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Sodium Nitrite results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Crp C-reactive protein multiple interactions
increases expression		 EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of CRP protein] CTD PMID:28266762 PMID:28833918 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO Sodium Nitrite results in decreased activity of G6PD protein CTD PMID:26231821 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity		 EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of GPT protein] CTD PMID:28833918 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO Sodium Nitrite results in decreased activity of GSR protein CTD PMID:26231821 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Sodium Nitrite results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions		 EXP Sodium Nitrite results in increased expression of HIF1A protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]		 CTD PMID:28000380 PMID:28266762 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion		 ISO Sodium Nitrite results in increased expression of IL1B mRNA
Sodium Nitrite results in increased secretion of IL1B protein		 CTD PMID:16581224 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Sodium Nitrite results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
multiple interactions		 ISO
EXP		 Sodium Nitrite results in increased secretion of IL6 protein
Sodium Nitrite results in increased expression of IL6 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of IL6 protein]		 CTD PMID:16581224 PMID:28266762 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ldhb lactate dehydrogenase B increases activity ISO Sodium Nitrite results in increased activity of LDHB protein CTD PMID:26231821 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Sodium Nitrite results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression		 EXP Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of NFKBIA mRNA] CTD PMID:28833918 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Sodium Nitrite results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,759,454...159,772,524
Ensembl chr 4:159,759,459...159,772,524 		JBrowse link
G Smad2 SMAD family member 2 increases expression
multiple interactions		 EXP Sodium Nitrite results in increased expression of SMAD2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]		 CTD PMID:28000380 PMID:28266762 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Stmn1 stathmin 1 increases expression ISO Sodium Nitrite results in increased expression of STMN1 protein CTD PMID:20025956 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions		 EXP Sodium Nitrite results in increased expression of TGFB1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein]		 CTD PMID:28266762 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion		 ISO
EXP		 Sodium Nitrite results in increased expression of TNF mRNA
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]
Sodium Nitrite results in increased secretion of TNF protein		 CTD PMID:16581224 PMID:28266762 PMID:28833918 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions		 EXP Sodium Nitrite results in increased expression of VEGFA protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of VEGFA protein]		 CTD PMID:28266762 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
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  CHEBI ontology 19765
    role 19738
      biological role 19736
        poison 18499
          sodium nitrite 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19765
    subatomic particle 19763
      composite particle 19763
        hadron 19763
          baryon 19763
            nucleon 19763
              atomic nucleus 19763
                atom 19763
                  main group element atom 19712
                    p-block element atom 19712
                      chalcogen 19506
                        oxygen atom 19482
                          oxygen molecular entity 19482
                            hydroxides 19276
                              oxoacid 18641
                                pnictogen oxoacid 11784
                                  nitrogen oxoacid 277
                                    nitrous acid 58
                                      nitrites 58
                                        nitrite salt 29
                                          sodium nitrite 29
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