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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.18 (myosin-light-chain kinase) inhibitor
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Accession:CHEBI:78763 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of myosin-light-chain kinase (EC 2.7.11.18).
Synonyms:related_synonym: ATP:myosin-light-chain O-phosphotransferase inhibitor;   ATP:myosin-light-chain O-phosphotransferase inhibitors;   EC 2.7.11.18 (myosin-light-chain kinase) inhibitors;   EC 2.7.11.18 inhibitor;   EC 2.7.11.18 inhibitors;   MLCK inhibitor;   MLCK inhibitors;   MLCkase inhibitor;   MLCkase inhibitors;   calcium/calmodulin-dependent myosin light chain kinase inhibitor;   calcium/calmodulin-dependent myosin light chain kinase inhibitors;   myosin kinase inhibitor;   myosin kinase inhibitors;   myosin light chain kinase inhibitor;   myosin light chain protein kinase inhibitor;   myosin light chain protein kinase inhibitors;   myosin light-chain kinase (phosphorylating) inhibitor;   myosin light-chain kinase (phosphorylating) inhibitors;   myosin light-chain kinase inhibitors;   smooth-muscle-myosin-light-chain kinase inhibitor;   smooth-muscle-myosin-light-chain kinase inhibitors
 xref: Wikipedia:Myosin_light-chain_kinase


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chrysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects activity
increases expression
decreases activity
multiple interactions
ISO chrysin affects the activity of ABCB1 protein
chrysin results in increased expression of ABCB1 protein
chrysin results in decreased activity of ABCB1 protein
[chrysin results in decreased activity of ABCB1 protein] which results in decreased export of Topotecan
CTD PMID:15796199 PMID:20457140 NCBI chr 4:25,357,467...25,529,941 JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO ABCC1 protein affects the reaction [chrysin results in increased transport of Glutathione] CTD PMID:21856323 NCBI chr10:528,961...655,179 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
decreases activity
ISO [chrysin results in decreased activity of ABCC2 protein] which results in decreased export of Topotecan; chrysin inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]
chrysin results in increased expression of ABCC2 protein
CTD PMID:15955639 PMID:20457140 NCBI chr 1:242,664,657...242,723,239 JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO ABCC3 protein affects the reaction [chrysin results in increased transport of Glutathione] CTD PMID:21856323 NCBI chr10:79,296,681...79,342,749 JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
decreases expression
ISO ABCC5 protein affects the reaction [chrysin results in increased transport of Glutathione]
chrysin results in decreased expression of ABCC5 mRNA; chrysin results in decreased expression of ABCC5 protein
CTD PMID:21856323 PMID:23994249 NCBI chr11:80,473,809...80,567,257 JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases activity
increases expression
decreases expression
ISO
EXP
[chrysin results in decreased activity of ABCG2 protein] which results in decreased export of Topotecan; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]
chrysin results in increased expression of ABCG2 mRNA; chrysin results in increased expression of ABCG2 protein
chrysin results in decreased expression of ABCG2 mRNA
chrysin inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]
CTD PMID:17077187 PMID:17093006 PMID:19732493 PMID:20457140 PMID:20816778 NCBI chr 4:87,676,241...87,802,757 JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA] CTD PMID:26297989 NCBI chr 1:231,746,527...231,759,307 JBrowse link
G Afp alpha-fetoprotein affects binding EXP chrysin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476 JBrowse link
G Ahr aryl hydrocarbon receptor affects activity
multiple interactions
ISO
EXP
chrysin affects the activity of AHR protein
chrysin binds to and results in increased activity of AHR protein
[chrysin co-treated with Methylcholanthrene] affects the activity of AHR protein; [chrysin co-treated with Tetrachlorodibenzodioxin] affects the activity of AHR protein; chrysin binds to and results in increased activity of AHR protein; chrysin inhibits the reaction [AHR protein binds to CYP1A1 promoter]; chrysin inhibits the reaction [AHR protein binds to UGT1A1 promoter]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; chrysin promotes the reaction [AHR protein binds to CYP1A1 promoter]
CTD PMID:14644660 PMID:16972788 PMID:17256720 PMID:19286049 NCBI chr 6:52,234,089...52,271,568 JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases expression ISO chrysin results in decreased expression of AKR1B10 mRNA; chrysin results in decreased expression of AKR1B10 protein CTD PMID:23994249 NCBI chr 4:63,038,459...63,060,336 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO BCL2 protein inhibits the reaction [chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; chrysin inhibits the reaction [AKT1 protein results in increased expression of MMP10 protein]; chrysin inhibits the reaction [AKT1 protein results in increased expression of SNAI1 protein]; chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein
chrysin results in decreased phosphorylation of AKT1 protein
CTD PMID:16215670 PMID:18455702 PMID:24122885 PMID:30578657 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Alb albumin multiple interactions EXP chrysin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein] CTD PMID:30794797 NCBI chr14:17,607,397...17,622,814 JBrowse link
G Apob apolipoprotein B multiple interactions ISO chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of APOB mRNA]; chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of APOB protein] CTD PMID:32220030 NCBI chr 6:30,844,386...30,883,983 JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO chrysin promotes the reaction [ARNT protein binds to CYP1A1 promoter] CTD PMID:16972788 NCBI chr 2:182,997,731...183,056,584 JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions EXP chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 protein] CTD PMID:21167192 NCBI chr10:55,146,887...55,154,854 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
chrysin inhibits the reaction [Isoniazid results in increased expression of BAX protein]; chrysin inhibits the reaction [Testosterone results in decreased expression of BAX mRNA]; chrysin promotes the reaction [Diethylnitrosamine results in increased expression of BAX protein]
[Cisplatin co-treated with chrysin] results in increased expression of BAX protein
CTD PMID:21167192 PMID:25770930 PMID:29247772 PMID:33121995 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases response to substance
ISO
EXP
BCL2 protein inhibits the reaction [chrysin results in decreased expression of XIAP protein]; BCL2 protein inhibits the reaction [chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; BCL2 protein inhibits the reaction [chrysin results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [chrysin results in increased degradation of PLCG1 protein]; chrysin inhibits the reaction [Cisplatin results in increased expression of BCL2 protein]
chrysin inhibits the reaction [Testosterone results in increased expression of BCL2 mRNA]
BCL2 protein results in decreased susceptibility to chrysin
CTD PMID:16215670 PMID:25770930 PMID:29247772 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein] CTD PMID:21167192 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions
ISO chrysin results in increased expression of BDNF protein
chrysin inhibits the reaction [Oxidopamine results in decreased expression of BDNF protein]
CTD PMID:29054324 NCBI chr 3:96,165,042...96,215,621 JBrowse link
G Casp1 caspase 1 multiple interactions ISO chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CASP1 protein] CTD PMID:21515303 NCBI chr 8:2,587,812...2,597,403 JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO
EXP
[Cisplatin co-treated with chrysin] results in increased cleavage of CASP3 protein; BCL2 protein inhibits the reaction [chrysin results in increased cleavage of and results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased cleavage of CASP3 protein]; chrysin inhibits the reaction [Topotecan results in increased activity of CASP3 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP3 protein]; chrysin results in increased cleavage of and results in increased activity of CASP3 protein
chrysin results in increased cleavage of CASP3 protein
[Diethylnitrosamine co-treated with chrysin] results in increased expression of CASP3 protein; chrysin inhibits the reaction [Acetaminophen results in increased activity of CASP3 protein]; chrysin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased activity of CASP3 protein]; chrysin inhibits the reaction [Testosterone results in decreased cleavage of CASP3 protein]; chrysin inhibits the reaction [Thioacetamide results in increased expression of CASP3 protein]
CTD PMID:16215670 PMID:18331776 PMID:19397994 PMID:20457140 PMID:21167192 PMID:21195158 PMID:24932515 PMID:25770930 PMID:28682524 PMID:29247772 PMID:30273961 PMID:30500344 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
ISO [Cisplatin co-treated with chrysin] results in increased cleavage of CASP8 protein; chrysin inhibits the reaction [Topotecan results in increased activity of CASP8 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP8 protein]
chrysin results in increased cleavage of CASP8 protein
CTD PMID:20457140 PMID:21195158 PMID:25770930 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO chrysin results in increased cleavage of CASP9 protein
[Cisplatin co-treated with chrysin] results in increased cleavage of CASP9 protein
CTD PMID:18331776 PMID:25770930 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP
ISO
chrysin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; chrysin inhibits the reaction [Colistin results in decreased activity of CAT protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; chrysin inhibits the reaction [Isoniazid results in decreased activity of CAT protein]; chrysin inhibits the reaction [Testosterone results in decreased activity of CAT protein]
chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased activity of CAT protein]
chrysin results in decreased activity of CAT protein
CTD PMID:10647909 PMID:23194824 PMID:28682524 PMID:29247772 PMID:30273961 PMID:32220030 PMID:33121995 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO chrysin results in decreased expression of CCNB1 mRNA; chrysin results in decreased expression of CCNB1 protein CTD PMID:18331776 PMID:19397994 NCBI chr 2:31,912,190...31,921,163 JBrowse link
G Cdh1 cadherin 1 increases expression ISO chrysin results in increased expression of CDH1 protein CTD PMID:24122885 PMID:30578657 NCBI chr19:34,492,371...34,561,775 JBrowse link
G Cdh2 cadherin 2 decreases expression ISO chrysin results in decreased expression of CDH2 protein CTD PMID:30578657 NCBI chr18:7,776,704...7,990,934 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO
EXP
chrysin results in increased expression of CDKN1A mRNA; chrysin results in increased expression of CDKN1A protein
chrysin inhibits the reaction [Testosterone results in decreased expression of CDKN1A mRNA]
CTD PMID:19397994 PMID:29247772 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C decreases expression ISO chrysin results in decreased expression of CDKN2C mRNA CTD PMID:18331776 NCBI chr 5:124,411,123...124,416,278 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO chrysin inhibits the reaction [Topotecan results in increased cleavage of CTNNB1 protein] CTD PMID:20457140 NCBI chr 8:120,640,008...120,667,110 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; chrysin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA] CTD PMID:19426678 NCBI chr14:15,704,772...15,706,969 JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
multiple interactions
ISO chrysin results in decreased activity of CYP19A1 protein
chrysin binds to and results in decreased activity of CYP19A1 protein
CTD PMID:9435150 PMID:10403137 PMID:15319488 NCBI chr 8:54,553,165...54,580,758 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases oxidation
increases expression
increases metabolic processing
decreases activity
increases activity
ISO [CYP1A1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; chrysin inhibits the reaction [AHR protein binds to CYP1A1 promoter]; chrysin inhibits the reaction [CYP1A1 results in increased activity of Benzo(a)pyrene]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; chrysin promotes the reaction [AHR protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ARNT protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]
CYP1A1 protein results in increased oxidation of chrysin
chrysin results in increased expression of CYP1A1 mRNA
chrysin promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
chrysin results in increased expression of CYP1A1 mRNA; chrysin results in increased expression of CYP1A1 protein
chrysin results in decreased activity of CYP1A1 protein
chrysin results in increased activity of CYP1A1 protein
CTD PMID:11752233 PMID:16972788 PMID:17012224 PMID:17256720 PMID:19666078 PMID:19766177 PMID:20816778 PMID:20930378 PMID:21053930 PMID:21482471 PMID:30964977 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
increases oxidation
multiple interactions
decreases activity
ISO CYP1A2 protein results in increased metabolism of chrysin
CYP1A2 protein results in increased oxidation of chrysin
[CYP1A2 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein
chrysin results in decreased activity of CYP1A2 protein
CTD PMID:19666078 PMID:20806393 PMID:21053930 PMID:30964977 NCBI chr 8:58,075,367...58,082,255 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases oxidation
increases metabolic processing
decreases activity
ISO [CYP1B1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; chrysin binds to and results in decreased activity of CYP1B1 protein
CYP1B1 protein alternative form results in increased oxidation of chrysin
chrysin results in decreased activity of CYP1B1 protein
CTD PMID:19666078 PMID:21053930 PMID:21482471 PMID:30964977 NCBI chr 6:15,342,312...15,350,886 JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases oxidation ISO CYP2A13 protein results in increased oxidation of chrysin CTD PMID:30964977 NCBI chr 1:82,231,611...82,244,887 JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [chrysin results in increased expression of CYP2B10 mRNA] CTD PMID:25625231 NCBI chr 1:81,518,387...81,544,999 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO chrysin results in increased expression of CYP2B6 mRNA CTD PMID:25625231 NCBI chr 1:81,652,762...81,732,153 JBrowse link
G Edn1 endothelin 1 increases expression ISO chrysin results in increased expression of EDN1 mRNA CTD PMID:18457675 NCBI chr17:22,454,924...22,460,812 JBrowse link
G Egf epidermal growth factor multiple interactions ISO chrysin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; chrysin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr 2:218,219,408...218,302,370 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO chrysin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:25625231 NCBI chr14:91,176,931...91,349,722 JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO chrysin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr  X:1,138,826...1,155,713 JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO chrysin binds to and results in increased activity of ESR1 protein; chrysin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ESR1 protein binds to TFF1 promoter] CTD PMID:9751507 PMID:16972788 PMID:29162470 PMID:33049310 NCBI chr 1:41,106,335...41,499,104 JBrowse link
G Esr2 estrogen receptor 2 affects binding
multiple interactions
ISO chrysin binds to ESR2 protein
chrysin binds to and results in increased activity of ESR2 protein
CTD PMID:9751507 PMID:12224631 PMID:33049310 NCBI chr 6:94,858,438...94,909,630 JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression ISO chrysin results in decreased expression of FADS2 mRNA CTD PMID:20816778 NCBI chr 1:206,707,384...206,747,333 JBrowse link
G Faslg Fas ligand multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of FASLG mRNA] CTD PMID:24932515 NCBI chr13:74,151,519...74,172,760 JBrowse link
G Fbp1 fructose-bisphosphatase 1 decreases expression ISO chrysin results in decreased expression of FBP1 mRNA CTD PMID:18331776 NCBI chr17:2,207,271...2,230,076 JBrowse link
G Fn1 fibronectin 1 increases expression ISO chrysin results in increased expression of FN1 protein CTD PMID:26408079 NCBI chr 9:73,196,044...73,264,695 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]] CTD PMID:15322261 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of FSHB protein] CTD PMID:24932515 NCBI chr 3:93,548,560...93,552,370 JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO chrysin results in increased expression of GADD45B mRNA; chrysin results in increased expression of GADD45B protein CTD PMID:18331776 NCBI chr 7:8,778,004...8,780,306 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
EXP [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [chrysin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; chrysin inhibits the reaction [Isoniazid results in increased expression of GCLC mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLC protein]
chrysin results in increased expression of GCLC mRNA; chrysin results in increased expression of GCLC protein
CTD PMID:22864849 PMID:33121995 NCBI chr 8:78,629,899...78,668,547 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
EXP [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [chrysin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; chrysin inhibits the reaction [Isoniazid results in increased expression of GCLM mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLM protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLM protein]
chrysin results in increased expression of GCLM mRNA; chrysin results in increased expression of GCLM protein
CTD PMID:22864849 PMID:33121995 NCBI chr 2:210,347,482...210,367,537 JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO chrysin inhibits the reaction [Oxidopamine results in decreased expression of GDNF protein] CTD PMID:29054324 NCBI chr 2:56,893,992...56,919,935 JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP mRNA]; chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP protein] CTD PMID:33121995 NCBI chr10:87,852,891...87,861,631 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP chrysin inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; chrysin inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:28682524 PMID:30794797 PMID:31625388 NCBI chr 7:108,416,646...108,419,495 JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO chrysin results in decreased expression of GRB2 protein CTD PMID:30578657 NCBI chr10:100,881,404...100,949,193 JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [chrysin results in increased expression of GREB1 mRNA] CTD PMID:33405908 NCBI chr 6:39,440,522...39,562,364 JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP chrysin results in decreased activity of GSR protein CTD PMID:10647909 NCBI chr16:58,482,209...58,525,256 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
increases expression
EXP
ISO
[chrysin results in increased expression of HMOX1 mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; chrysin inhibits the reaction [Isoniazid results in increased expression of HMOX1 mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
chrysin results in decreased expression of HMOX1 mRNA; chrysin results in decreased expression of HMOX1 protein
chrysin results in increased expression of HMOX1 mRNA; chrysin results in increased expression of HMOX1 protein
CTD PMID:22864849 PMID:23994249 PMID:33121995 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions ISO chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased phosphorylation of and affects the localization of HNF4A protein]
chrysin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HNF4A mRNA]; chrysin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of HNF4A protein]
CTD PMID:32220030 NCBI chr 3:152,186,787...152,248,320 JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15322261 PMID:16987811 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Ifng interferon gamma multiple interactions ISO chrysin inhibits the reaction [Oxidopamine results in increased expression of IFNG protein] CTD PMID:29054324 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP chrysin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA] CTD PMID:29247772 NCBI chr 7:22,282,895...22,361,972 JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions EXP chrysin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA] CTD PMID:29247772 NCBI chr 1:121,549,839...121,838,545 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO chrysin inhibits the reaction [nickel chloride results in increased phosphorylation of IKBKB protein] CTD PMID:30016632 NCBI chr16:69,319,487...69,373,251 JBrowse link
G Il10 interleukin 10 multiple interactions EXP
ISO
chrysin inhibits the reaction [Freund's Adjuvant results in decreased expression of IL10 protein]
chrysin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]
chrysin inhibits the reaction [Oxidopamine results in decreased expression of IL10 protein]
CTD PMID:24932515 PMID:29054324 PMID:30016632 NCBI chr13:42,472,625...42,477,308 JBrowse link
G Il15 interleukin 15 decreases expression ISO chrysin results in decreased expression of IL15 mRNA CTD PMID:20816778 NCBI chr19:25,640,013...25,706,818 JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL1B mRNA]; chrysin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; chrysin inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]
chrysin inhibits the reaction [Oxidopamine results in increased expression of IL1B protein]
chrysin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of IL1B mRNA]
chrysin results in decreased expression of IL1B mRNA
CTD PMID:18377686 PMID:20816778 PMID:21515303 PMID:28682524 PMID:29054324 PMID:30016632 PMID:33121995 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO chrysin results in decreased expression of IL1R1 mRNA CTD PMID:20816778 NCBI chr 9:42,504,917...42,580,958 JBrowse link
G Il4 interleukin 4 multiple interactions ISO chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 mRNA] CTD PMID:21515303 NCBI chr10:37,771,203...37,776,750 JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
decreases expression
ISO
EXP
chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL6 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]
chrysin inhibits the reaction [Oxidopamine results in increased expression of IL6 protein]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of IL6 mRNA]; chrysin inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
chrysin results in increased expression of IL6 mRNA
chrysin results in decreased expression of IL6 mRNA
CTD PMID:18457675 PMID:20816778 PMID:21515303 PMID:23194824 PMID:29054324 PMID:30016632 PMID:30500344 PMID:33121995 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO chrysin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA] CTD PMID:19426678 NCBI chr 1:95,479,966...95,484,926 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases phosphorylation
ISO chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; chrysin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]
chrysin results in decreased phosphorylation of JUN protein
CTD PMID:15322261 PMID:30578657 NCBI chr 5:109,894,175...109,897,268 JBrowse link
G Lamb2 laminin subunit beta 2 increases expression ISO chrysin results in increased expression of LAMB2 protein CTD PMID:26408079 NCBI chr 8:109,178,367...109,190,552 JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of LHB protein] CTD PMID:24932515 NCBI chr 1:95,898,269...95,901,973 JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP chrysin inhibits the reaction [Acetaminophen results in increased expression of MAP1LC3B protein]; chrysin inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein] CTD PMID:28682524 PMID:30273961 NCBI chr19:49,665,795...49,673,655 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity
EXP
ISO
MAPK1 protein affects the reaction [chrysin results in increased expression of GCLC protein]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLM protein]; MAPK1 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
[chrysin co-treated with Cisplatin] results in increased phosphorylation of MAPK1 protein
chrysin results in increased phosphorylation of MAPK1 protein
chrysin results in increased activity of MAPK1 protein
CTD PMID:22864849 PMID:25770930 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [chrysin co-treated with Cisplatin] results in increased phosphorylation of MAPK3 protein
chrysin results in increased phosphorylation of MAPK3 protein
CTD PMID:25770930 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression ISO chrysin results in decreased expression of MMP1 protein CTD PMID:30578657 NCBI chr 8:4,658,588...4,679,099 JBrowse link
G Mmp10 matrix metallopeptidase 10 multiple interactions
decreases expression
ISO chrysin inhibits the reaction [AKT1 protein results in increased expression of MMP10 protein]
chrysin results in decreased expression of MMP10 protein
CTD PMID:24122885 NCBI chr 8:4,689,840...4,697,748 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
ISO chrysin results in decreased expression of and results in decreased activity of MMP2 protein
chrysin results in decreased activity of MMP2 protein
CTD PMID:26408079 PMID:30578657 NCBI chr19:14,154,657...14,182,870 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO chrysin inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein] CTD PMID:30016632 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Mpo myeloperoxidase multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in increased activity of MPO protein] CTD PMID:24932515 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression
multiple interactions
ISO chrysin results in increased expression of MYBL1 mRNA
Fulvestrant inhibits the reaction [chrysin results in increased expression of MYBL1 mRNA]
CTD PMID:33405908 NCBI chr 5:9,582,905...9,618,179 JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO chrysin inhibits the reaction [nickel chloride results in increased expression of MYD88 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of MYD88 protein] CTD PMID:30016632 NCBI chr 8:119,074,439...119,078,508 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
decreases expression
EXP
ISO
chrysin affects the localization of and results in increased activity of NFE2L2 protein; chrysin inhibits the reaction [Isoniazid results in increased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLM protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
chrysin inhibits the reaction [NFE2L2 protein results in decreased susceptibility to Doxorubicin]
chrysin results in decreased expression of NFE2L2 mRNA; chrysin results in decreased expression of NFE2L2 protein
CTD PMID:22864849 PMID:23994249 PMID:33121995 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP chrysin inhibits the reaction [Isoniazid results in increased expression of NFKB1 mRNA]; chrysin inhibits the reaction [Thioacetamide results in increased expression of NFKB1 protein] CTD PMID:30500344 PMID:33121995 NCBI chr 2:224,016,214...224,132,135 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression
ISO chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased degradation of NFKBIA protein]; chrysin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; chrysin inhibits the reaction [nickel chloride results in increased phosphorylation of NFKBIA protein]
chrysin results in decreased expression of NFKBIA protein
CTD PMID:18377686 PMID:21515303 PMID:30016632 PMID:30578657 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Ngf nerve growth factor multiple interactions ISO chrysin inhibits the reaction [Oxidopamine results in decreased expression of NGF protein] CTD PMID:29054324 NCBI chr 2:189,901,058...189,954,452 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of NOS2 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of NOS2 protein]
CTD PMID:11343698 PMID:16934226 PMID:17570322 PMID:23194824 PMID:24932515 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP chrysin inhibits the reaction [alpha-naphthyl thiourea results in decreased expression of NOS3 mRNA] CTD PMID:30974023 NCBI chr 4:10,793,834...10,814,170 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP chrysin inhibits the reaction [Isoniazid results in increased expression of NQO1 mRNA] CTD PMID:33121995 NCBI chr19:35,295,633...35,310,528 JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO chrysin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO chrysin binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665 JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
multiple interactions
ISO chrysin affects the localization of NR1I3 protein
NR1I3 gene mutant form inhibits the reaction [chrysin results in increased expression of CYP2B10 mRNA]
CTD PMID:25625231 NCBI chr13:83,632,940...83,638,193 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO chrysin results in increased cleavage of PARP1 protein
[Cisplatin co-treated with chrysin] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased cleavage of PARP1 protein]
CTD PMID:18455702 PMID:25770930 NCBI chr13:92,307,593...92,339,406 JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein]; chrysin inhibits the reaction [Testosterone results in increased expression of PCNA protein] CTD PMID:23194824 PMID:29247772 NCBI chr 3:119,499,039...119,502,911 JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity ISO chrysin results in decreased activity of PGD protein CTD PMID:25130191 NCBI chr 5:159,582,746...159,598,945 JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO chrysin results in decreased expression of PLAU protein CTD PMID:30578657 NCBI chr15:3,456,230...3,462,732 JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
increases degradation
ISO BCL2 protein inhibits the reaction [chrysin results in increased degradation of PLCG1 protein] CTD PMID:16215670 NCBI chr 3:149,385,587...149,416,330 JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP2A6 protein co-treated with POR protein] results in increased oxidation of chrysin CTD PMID:30964977 NCBI chr12:20,951,058...20,999,198 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO chrysin results in decreased expression of PPARA mRNA CTD PMID:20816778 NCBI chr 7:116,832,405...116,900,878 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO chrysin binds to and results in increased activity of PPARG protein; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]] CTD PMID:11343698 PMID:33049310 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Psca prostate stem cell antigen decreases expression ISO chrysin results in decreased expression of PSCA mRNA CTD PMID:18331776 NCBI chr 7:106,598,203...106,603,114 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO
EXP
chrysin results in increased expression of PTGS2 mRNA
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 mRNA]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of PTGS2 protein]
chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
CTD PMID:11343698 PMID:18457675 PMID:21167192 PMID:23194824 PMID:24932515 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO chrysin results in decreased phosphorylation of PTK2 protein CTD PMID:30578657 NCBI chr 7:105,126,725...105,331,848 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
increases activity
ISO
EXP
Acetylcysteine inhibits the reaction [chrysin results in increased activity of RELA protein]; chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of RELA protein]; chrysin inhibits the reaction [nickel chloride affects the localization of RELA protein]; SB 203580 inhibits the reaction [chrysin results in increased activity of RELA protein]
chrysin results in decreased expression of RELA protein
chrysin inhibits the reaction [Oxidopamine results in increased phosphorylation of RELA protein]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein]; chrysin inhibits the reaction [Testosterone results in increased activity of RELA protein]
CTD PMID:18457675 PMID:21167192 PMID:21515303 PMID:23194824 PMID:29054324 PMID:29247772 PMID:30016632 PMID:30578657 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Rhoa ras homolog family member A decreases expression ISO chrysin results in decreased expression of RHOA protein CTD PMID:30578657 NCBI chr 8:108,991,926...109,025,746 JBrowse link
G RT1-Da RT1 class II, locus Da decreases expression ISO chrysin results in decreased expression of HLA-DRA mRNA CTD PMID:20816778 NCBI chr20:4,513,464...4,518,457 JBrowse link
G S100b S100 calcium binding protein B multiple interactions ISO chrysin inhibits the reaction [Oxidopamine results in increased expression of S100B protein] CTD PMID:29054324 NCBI chr20:12,372,866...12,381,619 JBrowse link
G Sc5d sterol-C5-desaturase decreases expression ISO chrysin results in decreased expression of SC5D mRNA CTD PMID:20816778 NCBI chr 8:42,629,649...42,641,257 JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO chrysin results in decreased expression of SCD mRNA CTD PMID:20816778 NCBI chr 1:243,269,745...243,282,878 JBrowse link
G Sele selectin E multiple interactions ISO chrysin inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16987811 NCBI chr13:76,402,841...76,412,741 JBrowse link
G Sfn stratifin increases expression ISO chrysin results in increased expression of SFN mRNA; chrysin results in increased expression of SFN protein CTD PMID:18331776
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions
ISO chrysin results in increased expression of SGK1 mRNA
Fulvestrant inhibits the reaction [chrysin results in increased expression of SGK1 mRNA]
CTD PMID:33405908 NCBI chr 1:22,980,257...23,098,122 JBrowse link
G Shbg sex hormone binding globulin affects binding ISO chrysin binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409 JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [chrysin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:192,123,755...192,144,617 JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD2 mRNA] CTD PMID:26297989 NCBI chr18:69,849,884...69,918,926 JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:26297989 NCBI chr 8:64,126,829...64,236,960 JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression
multiple interactions
ISO chrysin results in decreased expression of SNAI1 protein
chrysin inhibits the reaction [AKT1 protein results in increased expression of SNAI1 protein]
CTD PMID:24122885 PMID:30578657 NCBI chr 3:156,248,479...156,252,969 JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO chrysin results in decreased expression of SNAI2 protein CTD PMID:24122885 NCBI chr11:86,183,800...86,186,109 JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO chrysin results in decreased expression of SOS1 protein CTD PMID:30578657 NCBI chr 6:14,533,870...14,613,348 JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in decreased expression of STAR mRNA] CTD PMID:24932515 NCBI chr16:66,267,094...66,274,368 JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO SULT1A1 protein SNP results in increased sulfation of chrysin CTD PMID:17293380 NCBI chr 1:181,272,022...181,276,750 JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO SULT1E1 protein results in increased sulfation of and results in decreased activity of chrysin CTD PMID:17293380 NCBI chr14:20,422,324...20,439,562 JBrowse link
G Tbk1 TANK-binding kinase 1 decreases activity ISO chrysin results in decreased activity of TBK1 protein CTD PMID:19426678 NCBI chr 7:57,077,830...57,110,868 JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO chrysin promotes the reaction [ESR1 protein binds to TFF1 promoter] CTD PMID:16972788 NCBI chr20:9,235,736...9,239,597 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] CTD PMID:26297989 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO chrysin binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408 JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO chrysin binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920 JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO
EXP
chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 protein]
chrysin inhibits the reaction [Thioacetamide results in increased expression of TLR4 mRNA]
CTD PMID:30016632 PMID:30500344 NCBI chr 5:80,145,867...80,159,501 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TNF mRNA]; chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; chrysin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; chrysin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of SELE protein]; chrysin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein]; chrysin inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of TNF protein]; chrysin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]; Silymarin promotes the reaction [chrysin inhibits the reaction [Acetaminophen results in increased expression of TNF protein]]
chrysin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; chrysin inhibits the reaction [Oxidopamine results in increased expression of TNF protein]
CTD PMID:15322261 PMID:16934226 PMID:16987811 PMID:21515303 PMID:23194824 PMID:24932515 PMID:28682524 PMID:29054324 PMID:30016632 PMID:30500344 PMID:31625388 PMID:33121995 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance
ISO chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP3 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP8 protein]
chrysin results in increased susceptibility to TNFSF10 protein
CTD PMID:21195158 NCBI chr 2:110,199,835...110,227,239 JBrowse link
G Tp53 tumor protein p53 increases degradation
multiple interactions
ISO
EXP
chrysin results in increased degradation of TP53 protein
[Cisplatin co-treated with chrysin] affects the localization of TP53 protein; [Cisplatin co-treated with chrysin] results in increased phosphorylation of and results in increased expression of TP53 protein; chrysin results in increased phosphorylation of and affects the localization of TP53 protein; U 0126 inhibits the reaction [[Cisplatin co-treated with chrysin] affects the localization of TP53 protein]; U 0126 inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased phosphorylation of TP53 protein]
[Diethylnitrosamine co-treated with chrysin] results in increased expression of TP53 protein; chrysin inhibits the reaction [Diethylnitrosamine results in decreased expression of TP53 mRNA]; chrysin inhibits the reaction [Testosterone results in decreased expression of TP53 mRNA]
CTD PMID:14634213 PMID:21167192 PMID:25770930 PMID:29247772 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO chrysin results in increased expression of TP53I3 mRNA; chrysin results in increased expression of TP53I3 protein CTD PMID:18331776 PMID:19397994 NCBI chr13:69,612,605...69,655,018 JBrowse link
G Tp63 tumor protein p63 increases expression ISO chrysin results in increased expression of TP63 protein CTD PMID:18331776 PMID:19397994 NCBI chr11:74,838,858...75,049,764 JBrowse link
G Tp73 tumor protein p73 increases expression ISO chrysin results in increased expression of TP73 protein CTD PMID:18331776 PMID:19397994 NCBI chr 5:164,621,377...164,703,958 JBrowse link
G Tyr tyrosinase increases expression ISO chrysin results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:141,115,036...141,210,207 JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
affects glucuronidation
increases glucuronidation
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; chrysin inhibits the reaction [AHR protein binds to UGT1A1 promoter]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Ethinyl Estradiol]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Quercetin]; pyrazolanthrone inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; SB 203580 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; U 0126 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]
UGT1A1 protein affects the glucuronidation of chrysin
UGT1A1 protein results in increased glucuronidation of chrysin
chrysin results in increased expression of UGT1A1; chrysin results in increased expression of UGT1A1 mRNA; chrysin results in increased expression of UGT1A1 protein
CTD PMID:10950852 PMID:11442279 PMID:14557274 PMID:15104253 PMID:16003560 PMID:17256720 PMID:17599282 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects glucuronidation ISO UGT1A6 protein affects the glucuronidation of chrysin CTD PMID:10950852 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of chrysin CTD PMID:15502008 NCBI chr 9:88,739,577...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP
ISO
UGT1A8 protein results in increased glucuronidation of chrysin CTD PMID:14557274 PMID:15502008 NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
affects glucuronidation
ISO UGT1A9 protein results in increased glucuronidation of chrysin
UGT1A9 protein affects the glucuronidation of chrysin
CTD PMID:10950852 PMID:14557274 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Utrn utrophin increases expression ISO chrysin results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,720,854...7,224,313 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions
ISO chrysin results in increased expression of VCAM1 mRNA
chrysin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD PMID:16987811 PMID:18457675 NCBI chr 2:204,038,120...204,057,852 JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
ISO
EXP
chrysin results in decreased expression of VEGFA protein
chrysin inhibits the reaction [alpha-naphthyl thiourea results in increased expression of VEGFA mRNA]
CTD PMID:30578657 PMID:30974023 NCBI chr 9:14,955,300...14,970,641 JBrowse link
G Vim vimentin decreases expression ISO chrysin results in decreased expression of VIM protein CTD PMID:24122885 NCBI chr17:76,668,701...76,677,186 JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression
multiple interactions
ISO chrysin results in decreased expression of XIAP protein
BCL2 protein inhibits the reaction [chrysin results in decreased expression of XIAP protein]
CTD PMID:16215670 NCBI chr  X:120,890,537...120,938,413 JBrowse link
chrysin 5,7-dimethyl ether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of BAX protein CTD PMID:21554863 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein] CTD PMID:21554863 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Casp3 caspase 3 multiple interactions EXP 5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein] CTD PMID:21554863 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] CTD PMID:24134915 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] CTD PMID:21554863 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Csnk2b casein kinase 2 beta multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B protein] CTD PMID:21554863 NCBI chr20:3,700,363...3,705,331 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine affects the localization of CTNNB1 protein modified form]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA] CTD PMID:21554863 NCBI chr 8:120,640,008...120,667,110 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1A1 protein
CTD PMID:15661813 PMID:15905203 PMID:16484233 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity
ISO 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1B1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1B1 protein
CTD PMID:15905203 PMID:16484233 PMID:16530937 NCBI chr 6:15,342,312...15,350,886 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased phosphorylation of GSK3B protein] CTD PMID:21554863 NCBI chr11:62,498,997...62,648,665 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il6 interleukin 6 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of NOS2 protein] CTD PMID:21554863 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 protein] CTD PMID:21554863 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein modified form] CTD PMID:21554863 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 protein CTD PMID:21554863 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Wnt3a Wnt family member 3A multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of WNT3A protein] CTD PMID:21554863 NCBI chr10:44,034,174...44,078,463 JBrowse link
KT 5926 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcp1 lymphocyte cytosolic protein 1 multiple interactions ISO KT 5926 inhibits the reaction [calyculin A results in increased phosphorylation of LCP1 protein]; KT 5926 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of LCP1 protein] CTD PMID:14769871 NCBI chr15:50,443,300...50,544,682 JBrowse link
ML-7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression
affects localization
EXP
ISO
ML 7 results in decreased expression of ACTA2
ML 7 affects the localization of ACTA2 protein
CTD PMID:11591817 PMID:11868461 NCBI chr 1:231,746,527...231,759,307 JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases phosphorylation ISO ML 7 results in decreased phosphorylation of BCAR1 protein CTD PMID:18718759 NCBI chr19:39,679,218...39,713,952 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO ML 7 results in decreased expression of BIRC5 protein CTD PMID:18710790 NCBI chr10:103,072,530...103,081,382 JBrowse link
G Casp3 caspase 3 multiple interactions ISO [ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein; FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein] CTD PMID:16723733 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Ccna2 cyclin A2 multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of CCNA2 protein] CTD PMID:16799973 NCBI chr 2:119,427,239...119,433,645 JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
EXP
ISO
ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 mRNA]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 protein]
ML 7 results in decreased expression of CCND1 protein
CTD PMID:16799973 PMID:18710790 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Ccne1 cyclin E1 multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of CCNE1 protein] CTD PMID:16799973 NCBI chr 1:90,781,947...90,791,188 JBrowse link
G Cdh1 cadherin 1 decreases activity
affects localization
ISO ML 7 results in decreased activity of CDH1 protein
ML 7 affects the localization of CDH1 protein
CTD PMID:16030252 NCBI chr19:34,492,371...34,561,775 JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of CDK1 protein] CTD PMID:16799973 NCBI chr20:19,266,226...19,281,417 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO ML 7 results in decreased expression of CDKN1A protein CTD PMID:15252113 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO ML 7 results in increased expression of CDKN1B protein CTD PMID:15252113 NCBI chr 4:167,760,067...167,765,177 JBrowse link
G Col17a1 collagen type XVII alpha 1 chain affects localization ISO ML 7 affects the localization of COL17A1 protein CTD PMID:14691950 NCBI chr 1:246,530,589...246,577,632 JBrowse link
G Csf2 colony stimulating factor 2 affects activity ISO ML 7 affects the activity of CSF2 protein CTD PMID:8471626 NCBI chr10:38,386,945...38,388,926 JBrowse link
G Ctnnb1 catenin beta 1 affects localization
decreases expression
ISO ML 7 affects the localization of CTNNB1 protein
ML 7 results in decreased expression of CTNNB1 protein
CTD PMID:18710790 NCBI chr 8:120,640,008...120,667,110 JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO ML 7 inhibits the reaction [CXCL12 protein results in increased phosphorylation of MYL9 protein] CTD PMID:11751986 NCBI chr 4:150,388,326...150,401,173 JBrowse link
G Dst dystonin affects localization ISO ML 7 affects the localization of DST protein CTD PMID:14691950 NCBI chr 9:36,135,657...36,529,617 JBrowse link
G Egf epidermal growth factor multiple interactions EXP ML 7 inhibits the reaction [EGF protein affects the localization of MYL9 protein modified form]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCNA2 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 mRNA]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of FOS protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of JUN protein]; ML 7 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:16799973 NCBI chr 2:218,219,408...218,302,370 JBrowse link
G F2 coagulation factor II multiple interactions
affects activity
decreases activity
ISO
EXP
ML 7 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]
ML 7 affects the activity of F2 protein
[ML 7 results in decreased activity of MYLK protein] which results in decreased activity of F2 protein
CTD PMID:1643115 PMID:14557824 PMID:15284075 PMID:16675616 NCBI chr 3:77,596,196...77,609,486 JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein] CTD PMID:16723733 NCBI chr 1:199,743,200...199,745,746 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of FOS protein] CTD PMID:16799973 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP ML 7 inhibits the reaction [Ionomycin results in increased secretion of HEXB protein] CTD PMID:14499669 NCBI chr 2:28,483,997...28,504,165 JBrowse link
G Il17a interleukin 17A multiple interactions ISO ML 7 inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein] CTD PMID:19940258 NCBI chr 9:23,144,402...23,147,889 JBrowse link
G Itga3 integrin subunit alpha 3 multiple interactions ISO ML 7 affects the localization of [ITGA3 protein binds to ITGB1 protein] CTD PMID:14691950 NCBI chr10:79,990,160...80,022,206 JBrowse link
G Itga6 integrin subunit alpha 6 multiple interactions ISO ML 7 affects the localization of [ITGA6 protein binds to ITGB4 protein] CTD PMID:14691950 NCBI chr 3:56,604,512...56,689,428 JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein] CTD PMID:19374788 NCBI chr 1:182,659,047...182,709,495 JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions
decreases activity
ISO ML 7 affects the localization of [ITGA3 protein binds to ITGB1 protein]
ML 7 results in decreased activity of ITGB1 protein
CTD PMID:14691950 PMID:16723733 NCBI chr19:56,705,123...56,753,199 JBrowse link
G Itgb4 integrin subunit beta 4 multiple interactions ISO ML 7 affects the localization of [ITGA6 protein binds to ITGB4 protein] CTD PMID:14691950 NCBI chr10:101,206,657...101,243,012 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of JUN protein] CTD PMID:16799973 NCBI chr 5:109,894,175...109,897,268 JBrowse link
G Lama3 laminin subunit alpha 3 affects localization ISO ML 7 affects the localization of LAMA3 protein CTD PMID:14691950 NCBI chr18:3,523,168...3,751,722 JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO ML 7 results in decreased phosphorylation of MAPK1 protein CTD PMID:18710790 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO ML 7 results in decreased phosphorylation of MAPK3 protein CTD PMID:18710790 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
EXP
ISO
ML 7 inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]
ML 7 results in decreased activity of MPO protein
CTD PMID:15863634 PMID:19374788 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO ML 7 results in decreased expression of MYC protein CTD PMID:18710790 NCBI chr 7:93,593,705...93,598,633 JBrowse link
G Myh2 myosin heavy chain 2 affects localization
decreases activity
ISO ML 7 affects the localization of MYH2 protein
ML 7 results in decreased activity of MYH2 protein
CTD PMID:16030252 NCBI chr10:51,856,738...51,883,236 JBrowse link
G Myl7 myosin light chain 7 multiple interactions
decreases phosphorylation
ISO ML 7 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]
ML 7 results in decreased phosphorylation of MYL7 protein
CTD PMID:15621049 NCBI chr14:80,780,684...80,783,259 JBrowse link
G Myl9 myosin light chain 9 multiple interactions
decreases phosphorylation
decreases expression
ISO
EXP
[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; ML 7 inhibits the reaction [CXCL12 protein results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL9 protein]
ML 7 results in decreased phosphorylation of MYL9 protein
ML 7 inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein]
[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; ML 7 inhibits the reaction [Deamino Arginine Vasopressin results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [EGF protein affects the localization of MYL9 protein modified form]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL9 protein]
ML 7 results in decreased expression of MYL9 protein modified form
CTD PMID:1643115 PMID:7503253 PMID:9618396 PMID:11751986 PMID:12745062 PMID:15284075 PMID:15347643 PMID:15863634 PMID:16799973 PMID:17138966 PMID:17272349 PMID:17914957 PMID:18710790 PMID:18835913 PMID:19525378 PMID:19940258 PMID:19943851 NCBI chr 3:145,281,943...145,288,333 JBrowse link
G Mylk myosin light chain kinase multiple interactions
decreases activity
ISO
EXP
[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; [ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein; FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein]; ML 7 inhibits the reaction [Calcium deficiency results in increased activity of MYLK protein]; ML 7 inhibits the reaction [Ethanol results in increased activity of MYLK protein]
[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein
ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK mRNA]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK protein]; ML 7 inhibits the reaction [MYLK protein results in increased uptake of Glucose]
[ML 7 results in decreased activity of MYLK protein] which results in decreased activity of F2 protein; ML 7 results in decreased activity of MYLK protein
CTD PMID:1643115 PMID:9618396 PMID:10198341 PMID:10733514 PMID:11054866 PMID:12534346 PMID:16675616 PMID:16723733 PMID:17541957 PMID:18773891 PMID:18835913 PMID:19374788 PMID:19943851 NCBI chr11:65,783,008...66,030,239 JBrowse link
G Myod1 myogenic differentiation 1 decreases expression ISO ML 7 results in decreased expression of MYOD1 protein CTD PMID:15252113 NCBI chr 1:96,884,864...96,887,574 JBrowse link
G Myog myogenin decreases expression ISO ML 7 results in decreased expression of MYOG protein CTD PMID:15252113 NCBI chr13:45,745,455...45,748,044 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO ML 7 inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NCF1 protein]; ML 7 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NCF1 protein] CTD PMID:7575484 NCBI chr12:22,485,382...22,494,647 JBrowse link
G Prkcb protein kinase C, beta decreases expression EXP ML 7 results in decreased expression of PRKCB protein CTD PMID:17272349 NCBI chr 1:176,832,173...177,163,539 JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO ML 7 results in decreased phosphorylation of PTK2 protein CTD PMID:18718759 NCBI chr 7:105,126,725...105,331,848 JBrowse link
G Rac1 Rac family small GTPase 1 decreases activity
increases activity
EXP ML 7 results in decreased activity of RAC1 protein
ML 7 results in increased activity of RAC1 protein
CTD PMID:12105187 PMID:12745062 NCBI chr12:11,037,028...11,057,251 JBrowse link
G Ren renin multiple interactions
increases secretion
EXP [[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; calyculin A inhibits the reaction [ML 7 results in increased secretion of REN protein]; ML 7 inhibits the reaction [Calcium results in decreased secretion of REN protein] CTD PMID:9618396 NCBI chr13:44,796,260...44,807,491 JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases activity ISO ML 7 results in decreased activity of RPS6KA5 protein CTD PMID:12534346 NCBI chr 6:119,828,823...120,006,190 JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:16799973 NCBI chr10:71,323,777...71,367,908 JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
decreases expression
decreases activity
EXP ML 7 inhibits the reaction [SLC2A2 protein results in increased uptake of Glucose]
ML 7 results in decreased expression of SLC2A2 protein
ML 7 results in decreased activity of SLC2A2 protein
CTD PMID:17272349 NCBI chr 2:111,609,798...111,639,930 JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO ML 7 inhibits the reaction [Oxygen deficiency affects the localization of TJP1 protein] CTD PMID:20164382 NCBI chr 1:118,849,838...119,094,492 JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 decreases activity ISO ML 7 results in decreased activity of TRPC6 protein CTD PMID:17603544 NCBI chr 8:5,759,387...5,864,000 JBrowse link
G Trpc7 transient receptor potential cation channel, subfamily C, member 7 increases activity ISO ML 7 results in increased activity of TRPC7 protein CTD PMID:17603544 NCBI chr17:7,708,911...7,833,435 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        inhibitor 18454
          enzyme inhibitor 18247
            EC 2.* (transferase) inhibitor 13894
              EC 2.7.* (P-containing group transferase) inhibitor 13529
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8187
                  EC 2.7.11.18 (myosin-light-chain kinase) inhibitor 192
                    KT 5926 1
                    ML-7 50
                    cetylpyridinium bromide 0
                    chrysin + 154
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        inhibitor 18454
          enzyme inhibitor 18247
            EC 2.* (transferase) inhibitor 13894
              EC 2.7.* (P-containing group transferase) inhibitor 13529
                protein kinase inhibitor 13057
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8187
                    EC 2.7.11.18 (myosin-light-chain kinase) inhibitor 192
                      KT 5926 1
                      ML-7 50
                      cetylpyridinium bromide 0
                      chrysin + 154
paths to the root