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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 2.7.11.18 (myosin-light-chain kinase) inhibitor
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Accession:CHEBI:78763 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of myosin-light-chain kinase (EC 2.7.11.18).
Synonyms:related_synonym: ATP:myosin-light-chain O-phosphotransferase inhibitor;   ATP:myosin-light-chain O-phosphotransferase inhibitors;   EC 2.7.11.18 (myosin-light-chain kinase) inhibitors;   EC 2.7.11.18 inhibitor;   EC 2.7.11.18 inhibitors;   MLCK inhibitor;   MLCK inhibitors;   MLCkase inhibitor;   MLCkase inhibitors;   calcium/calmodulin-dependent myosin light chain kinase inhibitor;   calcium/calmodulin-dependent myosin light chain kinase inhibitors;   myosin kinase inhibitor;   myosin kinase inhibitors;   myosin light chain kinase inhibitor;   myosin light chain protein kinase inhibitor;   myosin light chain protein kinase inhibitors;   myosin light-chain kinase (phosphorylating) inhibitor;   myosin light-chain kinase (phosphorylating) inhibitors;   myosin-light-chain kinase inhibitors;   smooth-muscle-myosin-light-chain kinase inhibitor;   smooth-muscle-myosin-light-chain kinase inhibitors
 xref: Wikipedia:Myosin_light-chain_kinase


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chrysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects activity
decreases activity
increases expression
multiple interactions		 ISO chrysin affects the activity of ABCB1 protein
chrysin results in decreased activity of ABCB1 protein
chrysin results in increased expression of ABCB1 protein
[chrysin results in decreased activity of ABCB1 protein] which results in decreased export of Topotecan		 CTD PMID:15796199 PMID:20457140 PMID:27996361 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO ABCC1 protein affects the reaction [chrysin results in increased transport of Glutathione] CTD PMID:21856323 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
decreases activity		 ISO [chrysin results in decreased activity of ABCC2 protein] which results in decreased export of Topotecan; chrysin inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]
chrysin results in increased expression of ABCC2 protein		 CTD PMID:15955639 PMID:20457140 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO ABCC3 protein affects the reaction [chrysin results in increased transport of Glutathione] CTD PMID:21856323 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
decreases expression		 ISO ABCC5 protein affects the reaction [chrysin results in increased transport of Glutathione]
chrysin results in decreased expression of ABCC5 mRNA; chrysin results in decreased expression of ABCC5 protein		 CTD PMID:21856323 PMID:23994249 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases activity
decreases expression
increases expression		 ISO
EXP		 [chrysin results in decreased activity of ABCG2 protein] which results in decreased export of Topotecan; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]
chrysin inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]
chrysin results in decreased expression of ABCG2 mRNA
chrysin results in increased expression of ABCG2 mRNA; chrysin results in increased expression of ABCG2 protein		 CTD PMID:17077187 PMID:17093006 PMID:19732493 PMID:20457140 PMID:20816778 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO chrysin inhibits the reaction [Aluminum Chloride results in increased activity of ACHE protein] CTD PMID:34774662 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA] CTD PMID:26297989 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO chrysin results in increased expression of ADIPOQ protein CTD PMID:30445784 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Afp alpha-fetoprotein affects binding EXP chrysin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ahr aryl hydrocarbon receptor affects activity
multiple interactions		 ISO
EXP		 chrysin affects the activity of AHR protein
[chrysin co-treated with Methylcholanthrene] affects the activity of AHR protein; [chrysin co-treated with Tetrachlorodibenzodioxin] affects the activity of AHR protein; chrysin binds to and results in increased activity of AHR protein; chrysin inhibits the reaction [AHR protein binds to CYP1A1 promoter]; chrysin inhibits the reaction [AHR protein binds to UGT1A1 promoter]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; chrysin promotes the reaction [AHR protein binds to CYP1A1 promoter]		 CTD PMID:14644660 PMID:16972788 PMID:17256720 PMID:19286049 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases expression ISO chrysin results in decreased expression of AKR1B10 mRNA; chrysin results in decreased expression of AKR1B10 protein CTD PMID:23994249 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO BCL2 protein inhibits the reaction [chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; chrysin inhibits the reaction [AKT1 protein results in increased expression of MMP10 protein]; chrysin inhibits the reaction [AKT1 protein results in increased expression of SNAI1 protein]; chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein
chrysin results in decreased phosphorylation of AKT1 protein		 CTD PMID:16215670 PMID:18455702 PMID:24122885 PMID:30578657 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions EXP chrysin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein] CTD PMID:30794797 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Apob apolipoprotein B multiple interactions ISO chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of APOB mRNA]; chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of APOB protein] CTD PMID:32220030 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO chrysin promotes the reaction [ARNT protein binds to CYP1A1 promoter] CTD PMID:16972788 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions EXP chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 protein] CTD PMID:21167192 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO		 chrysin inhibits the reaction [Isoniazid results in increased expression of BAX protein]; chrysin inhibits the reaction [Testosterone results in decreased expression of BAX mRNA]; chrysin promotes the reaction [Diethylnitrosamine results in increased expression of BAX protein]
[Cisplatin co-treated with chrysin] results in increased expression of BAX protein		 CTD PMID:21167192 PMID:25770930 PMID:29247772 PMID:33121995 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO chrysin inhibits the reaction [Aluminum Chloride results in increased activity of BCHE protein] CTD PMID:34774662 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases response to substance		 ISO
EXP		 BCL2 protein inhibits the reaction [chrysin results in decreased expression of XIAP protein]; BCL2 protein inhibits the reaction [chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; BCL2 protein inhibits the reaction [chrysin results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [chrysin results in increased degradation of PLCG1 protein]; chrysin inhibits the reaction [Cisplatin results in increased expression of BCL2 protein]
chrysin inhibits the reaction [Testosterone results in increased expression of BCL2 mRNA]
BCL2 protein results in decreased susceptibility to chrysin		 CTD PMID:16215670 PMID:25770930 PMID:29247772 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein] CTD PMID:21167192 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions		 ISO chrysin results in increased expression of BDNF protein
chrysin inhibits the reaction [Oxidopamine results in decreased expression of BDNF protein]		 CTD PMID:29054324 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CASP1 protein] CTD PMID:21515303 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO
EXP		 [Cisplatin co-treated with chrysin] results in increased cleavage of CASP3 protein; BCL2 protein inhibits the reaction [chrysin results in increased cleavage of and results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased cleavage of CASP3 protein]; chrysin inhibits the reaction [Topotecan results in increased activity of CASP3 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP3 protein]; chrysin results in increased cleavage of and results in increased activity of CASP3 protein
chrysin results in increased cleavage of CASP3 protein
[Diethylnitrosamine co-treated with chrysin] results in increased expression of CASP3 protein; chrysin inhibits the reaction [Acetaminophen results in increased activity of CASP3 protein]; chrysin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased activity of CASP3 protein]; chrysin inhibits the reaction [Testosterone results in decreased cleavage of CASP3 protein]; chrysin inhibits the reaction [Thioacetamide results in increased expression of CASP3 protein]		 CTD PMID:16215670 PMID:18331776 PMID:19397994 PMID:20457140 PMID:21167192 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage		 ISO [Cisplatin co-treated with chrysin] results in increased cleavage of CASP8 protein; chrysin inhibits the reaction [Topotecan results in increased activity of CASP8 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP8 protein]
chrysin results in increased cleavage of CASP8 protein		 CTD PMID:20457140 PMID:21195158 PMID:25770930 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO chrysin results in increased cleavage of CASP9 protein
[Cisplatin co-treated with chrysin] results in increased cleavage of CASP9 protein		 CTD PMID:18331776 PMID:25770930 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 EXP
ISO		 chrysin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; chrysin inhibits the reaction [Colistin results in decreased activity of CAT protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; chrysin inhibits the reaction [Isoniazid results in decreased activity of CAT protein]; chrysin inhibits the reaction [Testosterone results in decreased activity of CAT protein]
chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased activity of CAT protein]; chrysin inhibits the reaction [Aluminum Chloride results in decreased activity of CAT protein]
chrysin results in decreased activity of CAT protein		 CTD PMID:10647909 PMID:23194824 PMID:28682524 PMID:29247772 PMID:30273961 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO chrysin results in decreased expression of CCNB1 mRNA; chrysin results in decreased expression of CCNB1 protein CTD PMID:18331776 PMID:19397994 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO chrysin results in increased expression of CDH1 protein CTD PMID:24122885 PMID:30578657 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO chrysin results in decreased expression of CDH2 protein CTD PMID:30578657 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO
EXP		 chrysin results in increased expression of CDKN1A mRNA; chrysin results in increased expression of CDKN1A protein
chrysin inhibits the reaction [Testosterone results in decreased expression of CDKN1A mRNA]		 CTD PMID:19397994 PMID:29247772 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C decreases expression ISO chrysin results in decreased expression of CDKN2C mRNA CTD PMID:18331776 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO chrysin results in increased expression of CEBPA protein CTD PMID:30445784 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO chrysin inhibits the reaction [Topotecan results in increased cleavage of CTNNB1 protein] CTD PMID:20457140 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; chrysin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA] CTD PMID:19426678 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
multiple interactions		 ISO chrysin results in decreased activity of CYP19A1 protein
chrysin binds to and results in decreased activity of CYP19A1 protein		 CTD PMID:9435150 PMID:10403137 PMID:15319488 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases oxidation
increases expression
increases metabolic processing
decreases activity
increases activity		 ISO [CYP1A1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; chrysin inhibits the reaction [AHR protein binds to CYP1A1 promoter]; chrysin inhibits the reaction [CYP1A1 results in increased activity of Benzo(a)pyrene]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; chrysin promotes the reaction [AHR protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ARNT protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]
CYP1A1 protein results in increased oxidation of chrysin
chrysin results in increased expression of CYP1A1 mRNA
chrysin promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
chrysin results in increased expression of CYP1A1 mRNA; chrysin results in increased expression of CYP1A1 protein
chrysin results in decreased activity of CYP1A1 protein
chrysin results in increased activity of CYP1A1 protein		 CTD PMID:11752233 PMID:16972788 PMID:17012224 PMID:17256720 PMID:19666078 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
increases oxidation
multiple interactions
decreases activity		 ISO CYP1A2 protein results in increased metabolism of chrysin
CYP1A2 protein results in increased oxidation of chrysin
[CYP1A2 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein
chrysin results in decreased activity of CYP1A2 protein		 CTD PMID:19666078 PMID:20806393 PMID:21053930 PMID:30964977 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases oxidation
increases metabolic processing
decreases activity		 ISO [CYP1B1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; chrysin binds to and results in decreased activity of CYP1B1 protein
CYP1B1 protein alternative form results in increased oxidation of chrysin
chrysin results in decreased activity of CYP1B1 protein		 CTD PMID:19666078 PMID:21053930 PMID:21482471 PMID:30964977 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases oxidation ISO CYP2A13 protein results in increased oxidation of chrysin CTD PMID:30964977 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions		 ISO chrysin results in increased expression of CYP2B6 mRNA
chrysin results in increased expression of CYP2B10 mRNA
NR1I3 gene mutant form inhibits the reaction [chrysin results in increased expression of CYP2B10 mRNA]		 CTD PMID:25625231 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
multiple interactions		 ISO chrysin results in increased activity of CYP3A4 protein
[[chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; chrysin binds to and results in decreased activity of CYP3A4 protein; chrysin inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein]		 CTD PMID:19766177 PMID:21053930 PMID:31756459 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Edn1 endothelin 1 increases expression ISO chrysin results in increased expression of EDN1 mRNA CTD PMID:18457675 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO chrysin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; chrysin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO chrysin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:25625231 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO chrysin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Epo erythropoietin increases expression ISO chrysin results in increased expression of EPO mRNA CTD PMID:37348668 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO chrysin binds to and results in increased activity of ESR1 protein; chrysin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ESR1 protein binds to TFF1 promoter] CTD PMID:9751507 PMID:16972788 PMID:29162470 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects binding
multiple interactions		 ISO chrysin binds to ESR2 protein
chrysin binds to and results in increased activity of ESR2 protein		 CTD PMID:9751507 PMID:12224631 PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression ISO chrysin results in decreased expression of FADS2 mRNA CTD PMID:20816778 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789 		JBrowse link
G Faslg Fas ligand multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of FASLG mRNA] CTD PMID:24932515 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fbp1 fructose-bisphosphatase 1 decreases expression ISO chrysin results in decreased expression of FBP1 mRNA CTD PMID:18331776 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO chrysin results in increased expression of FN1 protein CTD PMID:26408079 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]] CTD PMID:15322261 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO chrysin inhibits the reaction [Diazinon results in decreased expression of FOXP3 mRNA] CTD PMID:36114367 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of FSHB protein] CTD PMID:24932515 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO chrysin results in increased expression of GADD45B mRNA; chrysin results in increased expression of GADD45B protein CTD PMID:18331776 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046 		JBrowse link
G Gata3 GATA binding protein 3 multiple interactions ISO chrysin inhibits the reaction [Diazinon results in increased expression of GATA3 mRNA] CTD PMID:36114367 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression		 EXP [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [chrysin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; chrysin inhibits the reaction [Isoniazid results in increased expression of GCLC mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLC protein]
chrysin results in increased expression of GCLC mRNA; chrysin results in increased expression of GCLC protein		 CTD PMID:22864849 PMID:33121995 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression		 EXP [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [chrysin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; chrysin inhibits the reaction [Isoniazid results in increased expression of GCLM mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLM protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLM protein]
chrysin results in increased expression of GCLM mRNA; chrysin results in increased expression of GCLM protein		 CTD PMID:22864849 PMID:33121995 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO chrysin inhibits the reaction [Oxidopamine results in decreased expression of GDNF protein] CTD PMID:29054324 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP mRNA]; chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP protein] CTD PMID:33121995 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP chrysin inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; chrysin inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:28682524 PMID:30794797 PMID:31625388 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO chrysin results in decreased expression of GRB2 protein CTD PMID:30578657 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [chrysin results in increased expression of GREB1 mRNA] CTD PMID:33405908 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP chrysin results in decreased activity of GSR protein CTD PMID:10647909 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression		 ISO chrysin results in decreased degradation of and results in increased expression of HIF1A protein modified form
chrysin results in increased expression of HIF1A mRNA; chrysin results in increased expression of HIF1A protein		 CTD PMID:37348668 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
increases expression		 EXP
ISO		 [chrysin results in increased expression of HMOX1 mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; chrysin inhibits the reaction [Isoniazid results in increased expression of HMOX1 mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
chrysin results in decreased expression of HMOX1 mRNA; chrysin results in decreased expression of HMOX1 protein
chrysin results in increased expression of HMOX1 mRNA; chrysin results in increased expression of HMOX1 protein		 CTD PMID:22864849 PMID:23994249 PMID:33121995 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions ISO chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased phosphorylation of and affects the localization of HNF4A protein]
chrysin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HNF4A mRNA]; chrysin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of HNF4A protein]		 CTD PMID:32220030 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15322261 PMID:16987811 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions ISO chrysin inhibits the reaction [Diazinon results in decreased expression of IFNG mRNA]; chrysin inhibits the reaction [Diazinon results in decreased expression of IFNG protein]; chrysin inhibits the reaction [Oxidopamine results in increased expression of IFNG protein] CTD PMID:29054324 PMID:36114367 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP chrysin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA] CTD PMID:29247772 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions EXP chrysin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA] CTD PMID:29247772 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO chrysin inhibits the reaction [nickel chloride results in increased phosphorylation of IKBKB protein] CTD PMID:30016632 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP
ISO		 chrysin inhibits the reaction [Cyclophosphamide results in increased expression of IL10 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in decreased expression of IL10 protein]
chrysin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]
chrysin inhibits the reaction [Diazinon results in increased expression of IL10 mRNA]; chrysin inhibits the reaction [Oxidopamine results in decreased expression of IL10 protein]		 CTD PMID:24932515 PMID:29054324 PMID:30016632 PMID:36114367 PMID:37263553 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il15 interleukin 15 decreases expression ISO chrysin results in decreased expression of IL15 mRNA CTD PMID:20816778 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO chrysin inhibits the reaction [Diazinon results in increased expression of IL17A mRNA] CTD PMID:36114367 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO
EXP		 chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL1B mRNA]; chrysin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; chrysin inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]
chrysin inhibits the reaction [Oxidopamine results in increased expression of IL1B protein]
chrysin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]; chrysin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of IL1B mRNA]
chrysin results in decreased expression of IL1B mRNA		 CTD PMID:18377686 PMID:20816778 PMID:21515303 PMID:28682524 PMID:29054324 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO chrysin results in decreased expression of IL1R1 mRNA CTD PMID:20816778 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 mRNA]
chrysin inhibits the reaction [Diazinon results in increased expression of IL4 mRNA]		 CTD PMID:21515303 PMID:36114367 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
decreases expression		 ISO
EXP		 chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL6 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]
chrysin inhibits the reaction [Oxidopamine results in increased expression of IL6 protein]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein]; chrysin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of IL6 mRNA]; chrysin inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
chrysin results in increased expression of IL6 mRNA
chrysin results in decreased expression of IL6 mRNA		 CTD PMID:18457675 PMID:20816778 PMID:21515303 PMID:23194824 PMID:29054324 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [chrysin inhibits the reaction [Fructose results in increased expression of INS1 protein]]; chrysin inhibits the reaction [Fructose results in increased expression of INS1 protein] CTD PMID:25169908 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO chrysin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA] CTD PMID:19426678 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases phosphorylation		 ISO chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; chrysin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]
chrysin results in decreased phosphorylation of JUN protein		 CTD PMID:15322261 PMID:30578657 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions ISO chrysin inhibits the reaction [angiotensin II increases expression of KLF4 protein in vascular smooth muscle cells] RGD PMID:29127880 RGD:155230825 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Lamb2 laminin subunit beta 2 increases expression ISO chrysin results in increased expression of LAMB2 protein CTD PMID:26408079 NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549 		JBrowse link
G Lep leptin decreases expression ISO chrysin results in decreased expression of LEP protein CTD PMID:30445784 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of LHB protein] CTD PMID:24932515 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP chrysin inhibits the reaction [Acetaminophen results in increased expression of MAP1LC3B protein]; chrysin inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein] CTD PMID:28682524 PMID:30273961 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity		 EXP
ISO		 MAPK1 protein affects the reaction [chrysin results in increased expression of GCLC protein]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLM protein]; MAPK1 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
[chrysin co-treated with Cisplatin] results in increased phosphorylation of MAPK1 protein
chrysin results in increased phosphorylation of MAPK1 protein
chrysin results in increased activity of MAPK1 protein		 CTD PMID:22864849 PMID:25770930 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP chrysin inhibits the reaction [Cyclophosphamide results in increased expression of MAPK14 protein] CTD PMID:37263553 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO [chrysin co-treated with Cisplatin] results in increased phosphorylation of MAPK3 protein
chrysin results in increased phosphorylation of MAPK3 protein		 CTD PMID:25770930 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression ISO chrysin results in decreased expression of MMP1 protein CTD PMID:30578657 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp10 matrix metallopeptidase 10 multiple interactions
decreases expression		 ISO chrysin inhibits the reaction [AKT1 protein results in increased expression of MMP10 protein]
chrysin results in decreased expression of MMP10 protein		 CTD PMID:24122885 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity		 ISO chrysin results in decreased expression of and results in decreased activity of MMP2 protein
chrysin results in decreased activity of MMP2 protein		 CTD PMID:26408079 PMID:30578657 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO chrysin inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein] CTD PMID:30016632 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in increased activity of MPO protein] CTD PMID:24932515 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression
multiple interactions		 ISO chrysin results in increased expression of MYBL1 mRNA
Fulvestrant inhibits the reaction [chrysin results in increased expression of MYBL1 mRNA]		 CTD PMID:33405908 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO chrysin inhibits the reaction [nickel chloride results in increased expression of MYD88 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of MYD88 protein] CTD PMID:30016632 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression		 EXP
ISO		 chrysin affects the localization of and results in increased activity of NFE2L2 protein; chrysin inhibits the reaction [Isoniazid results in increased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLM protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
chrysin inhibits the reaction [NFE2L2 protein results in decreased susceptibility to Doxorubicin]
chrysin results in decreased expression of NFE2L2 mRNA; chrysin results in decreased expression of NFE2L2 protein		 CTD PMID:22864849 PMID:23994249 PMID:33121995 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP chrysin inhibits the reaction [Isoniazid results in increased expression of NFKB1 mRNA]; chrysin inhibits the reaction [Thioacetamide results in increased expression of NFKB1 protein] CTD PMID:30500344 PMID:33121995 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression		 ISO chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased degradation of NFKBIA protein]; chrysin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; chrysin inhibits the reaction [nickel chloride results in increased phosphorylation of NFKBIA protein]
chrysin results in decreased expression of NFKBIA protein		 CTD PMID:18377686 PMID:21515303 PMID:30016632 PMID:30578657 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO chrysin inhibits the reaction [Oxidopamine results in decreased expression of NGF protein] CTD PMID:29054324 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein]; chrysin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of NOS2 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of NOS2 protein]		 CTD PMID:11343698 PMID:16934226 PMID:17570322 PMID:23194824 PMID:24932515 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP chrysin inhibits the reaction [alpha-naphthyl thiourea results in decreased expression of NOS3 mRNA] CTD PMID:30974023 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP chrysin inhibits the reaction [Isoniazid results in increased expression of NQO1 mRNA] CTD PMID:33121995 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Chrysin increases expression of Nr1h3 mRNA in macrophages RGD PMID:25857322 RGD:401850558 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO chrysin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO chrysin binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
multiple interactions		 ISO chrysin affects the localization of NR1I3 protein
NR1I3 gene mutant form inhibits the reaction [chrysin results in increased expression of CYP2B10 mRNA]		 CTD PMID:25625231 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO
EXP		 chrysin results in increased cleavage of PARP1 protein
[Cisplatin co-treated with chrysin] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased cleavage of PARP1 protein]
chrysin inhibits the reaction [Cyclophosphamide results in increased expression of PARP1 protein]		 CTD PMID:18455702 PMID:25770930 PMID:37263553 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein]; chrysin inhibits the reaction [Testosterone results in increased expression of PCNA protein] CTD PMID:23194824 PMID:29247772 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity ISO chrysin results in decreased activity of PGD protein CTD PMID:25130191 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO chrysin results in decreased expression of PLAU protein CTD PMID:30578657 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
increases degradation		 ISO BCL2 protein inhibits the reaction [chrysin results in increased degradation of PLCG1 protein] CTD PMID:16215670 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP2A6 protein co-treated with POR protein] results in increased oxidation of chrysin CTD PMID:30964977 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO chrysin results in decreased expression of PPARA mRNA CTD PMID:20816778 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO chrysin binds to and results in increased activity of PPARG protein; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]] CTD PMID:11343698 PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Psca prostate stem cell antigen decreases expression ISO chrysin results in decreased expression of PSCA mRNA CTD PMID:18331776 NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO
EXP		 chrysin results in increased expression of PTGS2 mRNA
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 mRNA]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of PTGS2 protein]
chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]		 CTD PMID:11343698 PMID:18457675 PMID:21167192 PMID:23194824 PMID:24932515 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO chrysin results in decreased phosphorylation of PTK2 protein CTD PMID:30578657 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rbp4 retinol binding protein 4 decreases expression ISO chrysin results in decreased expression of RBP4 protein CTD PMID:30445784 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
increases activity		 ISO
EXP		 Acetylcysteine inhibits the reaction [chrysin results in increased activity of RELA protein]; chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of RELA protein]; chrysin inhibits the reaction [nickel chloride affects the localization of RELA protein]; SB 203580 inhibits the reaction [chrysin results in increased activity of RELA protein]
chrysin results in decreased expression of RELA protein
chrysin inhibits the reaction [Oxidopamine results in increased phosphorylation of RELA protein]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein]; chrysin inhibits the reaction [Testosterone results in increased activity of RELA protein]		 CTD PMID:18457675 PMID:21167192 PMID:21515303 PMID:23194824 PMID:29054324 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO chrysin results in decreased expression of RHOA protein CTD PMID:30578657 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO chrysin inhibits the reaction [Diazinon results in increased expression of RORC mRNA] CTD PMID:36114367 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G RT1-Da RT1 class II, locus Da decreases expression ISO chrysin results in decreased expression of HLA-DRA mRNA CTD PMID:20816778 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455 		JBrowse link
G S100b S100 calcium binding protein B multiple interactions ISO chrysin inhibits the reaction [Oxidopamine results in increased expression of S100B protein] CTD PMID:29054324 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Sc5d sterol-C5-desaturase decreases expression ISO chrysin results in decreased expression of SC5D mRNA CTD PMID:20816778 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO chrysin results in decreased expression of SCD mRNA CTD PMID:20816778 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sele selectin E multiple interactions ISO chrysin inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16987811 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sfn stratifin increases expression ISO chrysin results in increased expression of SFN mRNA; chrysin results in increased expression of SFN protein CTD PMID:18331776 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions		 ISO chrysin results in increased expression of SGK1 mRNA
Fulvestrant inhibits the reaction [chrysin results in increased expression of SGK1 mRNA]		 CTD PMID:33405908 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO chrysin binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [chrysin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD2 mRNA] CTD PMID:26297989 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:26297989 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression
multiple interactions		 ISO chrysin results in decreased expression of SNAI1 protein
chrysin inhibits the reaction [AKT1 protein results in increased expression of SNAI1 protein]		 CTD PMID:24122885 PMID:30578657 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO chrysin results in decreased expression of SNAI2 protein CTD PMID:24122885 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO chrysin results in decreased expression of SOS1 protein CTD PMID:30578657 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in decreased expression of STAR mRNA] CTD PMID:24932515 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP chrysin inhibits the reaction [Cyclophosphamide results in increased phosphorylation of STAT3 protein] CTD PMID:37263553 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO SULT1A1 protein SNP results in increased sulfation of chrysin CTD PMID:17293380 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO SULT1E1 protein results in increased sulfation of and results in decreased activity of chrysin CTD PMID:17293380 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Tbk1 TANK-binding kinase 1 decreases activity ISO chrysin results in decreased activity of TBK1 protein CTD PMID:19426678 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892 		JBrowse link
G Tbx21 T-box transcription factor 21 multiple interactions ISO chrysin inhibits the reaction [Diazinon results in decreased expression of TBX21 mRNA] CTD PMID:36114367 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO chrysin promotes the reaction [ESR1 protein binds to TFF1 promoter] CTD PMID:16972788 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; chrysin inhibits the reaction [Diazinon results in increased expression of TGFB1 mRNA] CTD PMID:26297989 PMID:36114367 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO chrysin binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO chrysin binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO
EXP		 chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 protein]
chrysin inhibits the reaction [Thioacetamide results in increased expression of TLR4 mRNA]		 CTD PMID:30016632 PMID:30500344 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TNF mRNA]; chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; chrysin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of SELE protein]; chrysin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
chrysin results in decreased expression of TNF protein
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein]; chrysin inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; chrysin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of TNF protein]; chrysin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]; Silymarin promotes the reaction [chrysin inhibits the reaction [Acetaminophen results in increased expression of TNF protein]]
chrysin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; chrysin inhibits the reaction [Oxidopamine results in increased expression of TNF protein]		 CTD PMID:15322261 PMID:16934226 PMID:16987811 PMID:21515303 PMID:23194824 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance		 ISO chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP3 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP8 protein]
chrysin results in increased susceptibility to TNFSF10 protein		 CTD PMID:21195158 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 increases degradation
affects activity
multiple interactions		 ISO
EXP		 chrysin results in increased degradation of TP53 protein
chrysin affects the activity of TP53 protein
[Cisplatin co-treated with chrysin] affects the localization of TP53 protein; [Cisplatin co-treated with chrysin] results in increased phosphorylation of and results in increased expression of TP53 protein; chrysin results in increased phosphorylation of and affects the localization of TP53 protein; U 0126 inhibits the reaction [[Cisplatin co-treated with chrysin] affects the localization of TP53 protein]; U 0126 inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased phosphorylation of TP53 protein]
[Diethylnitrosamine co-treated with chrysin] results in increased expression of TP53 protein; chrysin inhibits the reaction [Diethylnitrosamine results in decreased expression of TP53 mRNA]; chrysin inhibits the reaction [Testosterone results in decreased expression of TP53 mRNA]		 CTD PMID:14634213 PMID:21167192 PMID:25770930 PMID:29247772 PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO chrysin results in increased expression of TP53I3 mRNA; chrysin results in increased expression of TP53I3 protein CTD PMID:18331776 PMID:19397994 NCBI chr 6:27,818,327...27,825,753 JBrowse link
G Tp63 tumor protein p63 increases expression ISO chrysin results in increased expression of TP63 protein CTD PMID:18331776 PMID:19397994 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Tp73 tumor protein p73 increases expression ISO chrysin results in increased expression of TP73 protein CTD PMID:18331776 PMID:19397994 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Tyr tyrosinase increases expression ISO chrysin results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
affects glucuronidation
increases glucuronidation
increases expression		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; chrysin inhibits the reaction [AHR protein binds to UGT1A1 promoter]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Ethinyl Estradiol]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Quercetin]; pyrazolanthrone inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; SB 203580 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; U 0126 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]
UGT1A1 protein affects the glucuronidation of chrysin
UGT1A1 protein results in increased glucuronidation of chrysin
chrysin results in increased expression of UGT1A1; chrysin results in increased expression of UGT1A1 mRNA; chrysin results in increased expression of UGT1A1 protein		 CTD PMID:10950852 PMID:11442279 PMID:14557274 PMID:15104253 PMID:16003560 More... NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects glucuronidation ISO UGT1A6 protein affects the glucuronidation of chrysin CTD PMID:10950852 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of chrysin; UGT1A8 protein results in increased glucuronidation of chrysin CTD PMID:15502008 NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
affects glucuronidation		 ISO UGT1A9 protein results in increased glucuronidation of chrysin
UGT1A9 protein affects the glucuronidation of chrysin		 CTD PMID:10950852 PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Utrn utrophin increases expression ISO chrysin results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions		 ISO chrysin results in increased expression of VCAM1 mRNA
chrysin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]		 CTD PMID:16987811 PMID:18457675 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions		 ISO
EXP		 chrysin results in decreased expression of VEGFA protein
chrysin inhibits the reaction [alpha-naphthyl thiourea results in increased expression of VEGFA mRNA]		 CTD PMID:30578657 PMID:30974023 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin decreases expression ISO chrysin results in decreased expression of VIM protein CTD PMID:24122885 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression
multiple interactions		 ISO chrysin results in decreased expression of XIAP protein
BCL2 protein inhibits the reaction [chrysin results in decreased expression of XIAP protein]		 CTD PMID:16215670 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
chrysin 5,7-dimethyl ether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; 5,7-dimethoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5,7-dimethoxyflavone inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] CTD PMID:34217736 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of BAX protein CTD PMID:21554863 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein] CTD PMID:21554863 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP 5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein] CTD PMID:21554863 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] CTD PMID:24134915 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] CTD PMID:21554863 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Csnk2b casein kinase 2 beta multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B protein] CTD PMID:21554863 NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine affects the localization of CTNNB1 protein modified form]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA] CTD PMID:21554863 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity		 ISO 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1A1 protein		 CTD PMID:15661813 PMID:15905203 PMID:16484233 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity		 ISO 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1B1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1B1 protein		 CTD PMID:15905203 PMID:16484233 PMID:16530937 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased phosphorylation of GSK3B protein] CTD PMID:21554863 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of NOS2 protein] CTD PMID:21554863 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 protein] CTD PMID:21554863 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein modified form] CTD PMID:21554863 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 protein CTD PMID:21554863 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Wnt3a Wnt family member 3A multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of WNT3A protein] CTD PMID:21554863 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
KT 5926 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcp1 lymphocyte cytosolic protein 1 multiple interactions ISO KT 5926 inhibits the reaction [calyculin A results in increased phosphorylation of LCP1 protein]; KT 5926 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of LCP1 protein] CTD PMID:14769871 NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680 		JBrowse link
ML-7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression
affects localization		 EXP
ISO		 ML 7 results in decreased expression of ACTA2
ML 7 affects the localization of ACTA2 protein		 CTD PMID:11591817 PMID:11868461 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO ML 7 results in decreased susceptibility to [quinocetone results in increased phosphorylation of AKT1 protein] CTD PMID:26446980 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [ML 7 co-treated with quinocetone] results in increased expression of BAX protein; ML 7 results in increased susceptibility to [quinocetone results in increased expression of BAX protein] CTD PMID:26446980 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases phosphorylation ISO ML 7 results in decreased phosphorylation of BCAR1 protein CTD PMID:18718759 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [ML 7 co-treated with quinocetone] results in decreased expression of BCL2 protein; ML 7 results in increased susceptibility to [quinocetone results in decreased expression of BCL2 protein] CTD PMID:26446980 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO ML 7 results in decreased expression of BIRC5 protein CTD PMID:18710790 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [ML 7 co-treated with quinocetone] results in increased cleavage of CASP3 protein; [ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein; FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein] CTD PMID:16723733 PMID:26446980 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [ML 7 co-treated with quinocetone] results in increased cleavage of CASP8 protein; ML 7 results in increased susceptibility to [quinocetone results in increased cleavage of CASP8 protein] CTD PMID:26446980 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [ML 7 co-treated with quinocetone] results in increased cleavage of CASP9 protein; ML 7 results in increased susceptibility to [quinocetone results in increased cleavage of CASP9 protein] CTD PMID:26446980 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccna2 cyclin A2 multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of CCNA2 protein] CTD PMID:16799973 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 EXP
ISO		 ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 mRNA]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 protein]
ML 7 results in decreased expression of CCND1 protein		 CTD PMID:16799973 PMID:18710790 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of CCNE1 protein] CTD PMID:16799973 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdh1 cadherin 1 decreases activity
affects localization		 ISO ML 7 results in decreased activity of CDH1 protein
ML 7 affects the localization of CDH1 protein		 CTD PMID:16030252 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of CDK1 protein] CTD PMID:16799973 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO ML 7 results in decreased expression of CDKN1A protein CTD PMID:15252113 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO ML 7 results in increased expression of CDKN1B protein CTD PMID:15252113 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Col17a1 collagen type XVII alpha 1 chain affects localization ISO ML 7 affects the localization of COL17A1 protein CTD PMID:14691950 NCBI chr 1:246,530,589...246,577,559
Ensembl chr 1:246,531,367...246,577,632 		JBrowse link
G Csf2 colony stimulating factor 2 affects activity ISO ML 7 affects the activity of CSF2 protein CTD PMID:8471626 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctnnb1 catenin beta 1 affects localization
decreases expression		 ISO ML 7 affects the localization of CTNNB1 protein
ML 7 results in decreased expression of CTNNB1 protein		 CTD PMID:18710790 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO ML 7 inhibits the reaction [CXCL12 protein results in increased phosphorylation of MYL9 protein] CTD PMID:11751986 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Dst dystonin affects localization ISO ML 7 affects the localization of DST protein CTD PMID:14691950 NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP ML 7 inhibits the reaction [EGF protein affects the localization of MYL9 protein modified form]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCNA2 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 mRNA]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of FOS protein]; ML 7 inhibits the reaction [EGF protein results in increased expression of JUN protein]; ML 7 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:16799973 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions
decreases activity
affects activity		 ISO
EXP		 ML 7 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]
[ML 7 results in decreased activity of MYLK protein] which results in decreased activity of F2 protein
ML 7 affects the activity of F2 protein		 CTD PMID:1643115 PMID:14557824 PMID:15284075 PMID:16675616 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein] CTD PMID:16723733 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of FOS protein] CTD PMID:16799973 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP ML 7 inhibits the reaction [Ionomycin results in increased secretion of HEXB protein] CTD PMID:14499669 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO ML 7 inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein] CTD PMID:19940258 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Itga3 integrin subunit alpha 3 multiple interactions ISO ML 7 affects the localization of [ITGA3 protein binds to ITGB1 protein] CTD PMID:14691950 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118 		JBrowse link
G Itga6 integrin subunit alpha 6 multiple interactions ISO ML 7 affects the localization of [ITGA6 protein binds to ITGB4 protein] CTD PMID:14691950 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein] CTD PMID:19374788 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions
decreases activity		 ISO ML 7 affects the localization of [ITGA3 protein binds to ITGB1 protein]
ML 7 results in decreased activity of ITGB1 protein		 CTD PMID:14691950 PMID:16723733 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Itgb4 integrin subunit beta 4 multiple interactions ISO ML 7 affects the localization of [ITGA6 protein binds to ITGB4 protein] CTD PMID:14691950 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP ML 7 inhibits the reaction [EGF protein results in increased expression of JUN protein] CTD PMID:16799973 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lama3 laminin subunit alpha 3 affects localization ISO ML 7 affects the localization of LAMA3 protein CTD PMID:14691950 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO ML 7 results in decreased phosphorylation of MAPK1 protein
[ML 7 co-treated with quinocetone] results in increased phosphorylation of MAPK1 protein; ML 7 results in increased susceptibility to [quinocetone results in increased phosphorylation of MAPK1 protein]		 CTD PMID:18710790 PMID:26446980 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [ML 7 co-treated with quinocetone] results in increased phosphorylation of MAPK14 protein; ML 7 results in increased susceptibility to [quinocetone results in increased phosphorylation of MAPK14 protein] CTD PMID:26446980 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO ML 7 results in decreased phosphorylation of MAPK3 protein CTD PMID:18710790 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [ML 7 co-treated with quinocetone] results in increased phosphorylation of MAPK8 protein CTD PMID:26446980 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity		 EXP
ISO		 ML 7 inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]
ML 7 results in decreased activity of MPO protein		 CTD PMID:15863634 PMID:19374788 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO ML 7 results in decreased expression of MYC protein CTD PMID:18710790 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myh2 myosin heavy chain 2 affects localization
decreases activity		 ISO ML 7 affects the localization of MYH2 protein
ML 7 results in decreased activity of MYH2 protein		 CTD PMID:16030252 NCBI chr10:51,856,738...51,883,236
Ensembl chr10:51,856,738...51,883,236 		JBrowse link
G Myl7 myosin light chain 7 multiple interactions
decreases phosphorylation		 ISO ML 7 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]
ML 7 results in decreased phosphorylation of MYL7 protein		 CTD PMID:15621049 NCBI chr14:80,780,684...80,783,259
Ensembl chr14:80,779,776...80,783,244 		JBrowse link
G Myl9 myosin light chain 9 multiple interactions
decreases phosphorylation
decreases expression		 ISO
EXP		 [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; ML 7 inhibits the reaction [CXCL12 protein results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL9 protein]
ML 7 results in decreased phosphorylation of MYL9 protein
ML 7 inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein]
[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; ML 7 inhibits the reaction [Deamino Arginine Vasopressin results in increased phosphorylation of MYL9 protein]; ML 7 inhibits the reaction [EGF protein affects the localization of MYL9 protein modified form]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL9 protein]
ML 7 results in decreased expression of MYL9 protein modified form		 CTD PMID:1643115 PMID:7503253 PMID:9618396 PMID:11751986 PMID:12745062 More... NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Mylk myosin light chain kinase multiple interactions
decreases activity		 ISO
EXP		 [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; [ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein; FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein]; ML 7 inhibits the reaction [Calcium deficiency results in increased activity of MYLK protein]; ML 7 inhibits the reaction [Ethanol results in increased activity of MYLK protein]
[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein
ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK mRNA]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK protein]; ML 7 inhibits the reaction [MYLK protein results in increased uptake of Glucose]
[ML 7 results in decreased activity of MYLK protein] which results in decreased activity of F2 protein; ML 7 results in decreased activity of MYLK protein		 CTD PMID:1643115 PMID:9618396 PMID:10198341 PMID:10733514 PMID:11054866 More... NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Myod1 myogenic differentiation 1 decreases expression ISO ML 7 results in decreased expression of MYOD1 protein CTD PMID:15252113 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554 		JBrowse link
G Myog myogenin decreases expression ISO ML 7 results in decreased expression of MYOG protein CTD PMID:15252113 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO ML 7 inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NCF1 protein]; ML 7 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NCF1 protein] CTD PMID:7575484 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Prkcb protein kinase C, beta decreases expression EXP ML 7 results in decreased expression of PRKCB protein CTD PMID:17272349 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO ML 7 results in decreased phosphorylation of PTK2 protein CTD PMID:18718759 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rac1 Rac family small GTPase 1 decreases activity
increases activity		 EXP ML 7 results in decreased activity of RAC1 protein
ML 7 results in increased activity of RAC1 protein		 CTD PMID:12105187 PMID:12745062 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Ren renin multiple interactions
increases secretion		 EXP [[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; calyculin A inhibits the reaction [ML 7 results in increased secretion of REN protein]; ML 7 inhibits the reaction [Calcium results in decreased secretion of REN protein] CTD PMID:9618396 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases activity ISO ML 7 results in decreased activity of RPS6KA5 protein CTD PMID:12534346 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP
ISO		 ML 7 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]
ML 7 results in decreased susceptibility to [quinocetone results in increased phosphorylation of RPS6KB1 protein]		 CTD PMID:16799973 PMID:26446980 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
decreases activity
decreases expression		 EXP ML 7 inhibits the reaction [SLC2A2 protein results in increased uptake of Glucose]
ML 7 results in decreased activity of SLC2A2 protein
ML 7 results in decreased expression of SLC2A2 protein		 CTD PMID:17272349 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO ML 7 inhibits the reaction [Oxygen deficiency affects the localization of TJP1 protein]
ML 7 inhibits the reaction [Luteolin inhibits the reaction [decabromobiphenyl ether results in decreased expression of TJP1 protein]]		 CTD PMID:20164382 PMID:33675858 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 decreases activity ISO ML 7 results in decreased activity of TRPC6 protein CTD PMID:17603544 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Trpc7 transient receptor potential cation channel, subfamily C, member 7 increases activity ISO ML 7 results in increased activity of TRPC7 protein CTD PMID:17603544 NCBI chr17:7,708,911...7,833,435
Ensembl chr17:7,709,583...7,833,435 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        inhibitor 18875
          enzyme inhibitor 18702
            EC 2.* (transferase) inhibitor 14860
              EC 2.7.* (P-containing group transferase) inhibitor 14369
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 10113
                  EC 2.7.11.18 (myosin-light-chain kinase) inhibitor 208
                    KT 5926 1
                    ML-7 57
                    cetylpyridinium bromide 0
                    chrysin + 170
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        inhibitor 18875
          enzyme inhibitor 18702
            EC 2.* (transferase) inhibitor 14860
              EC 2.7.* (P-containing group transferase) inhibitor 14369
                protein kinase inhibitor 13972
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 10113
                    EC 2.7.11.18 (myosin-light-chain kinase) inhibitor 208
                      KT 5926 1
                      ML-7 57
                      cetylpyridinium bromide 0
                      chrysin + 170
paths to the root