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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.1.91 (sphingosine kinase) inhibitor
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Accession:CHEBI:78760 term browser browse the term
Definition:An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of sphinganine kinase (EC 2.7.1.91).
Synonyms:related_synonym: ATP:sphinganine 1-phosphotransferase inhibitor;   ATP:sphinganine 1-phosphotransferase inhibitors;   EC 2.7.1.91 (sphinganine kinase) inhibitor;   EC 2.7.1.91 (sphinganine kinase) inhibitors;   EC 2.7.1.91 (sphingosine kinase) inhibitors;   EC 2.7.1.91 inhibitor;   EC 2.7.1.91 inhibitors;   SGK inhibitor;   SGK inhibitors;   SK inhibitor;   SK inhibitors;   dihydrosphingosine kinase (phosphorylating) inhibitor;   dihydrosphingosine kinase (phosphorylating) inhibitors;   dihydrosphingosine kinase inhibitor;   dihydrosphingosine kinase inhibitors;   sphinganine kinase inhibitor;   sphinganine kinase inhibitors;   sphingoid base kinase inhibitor;   sphingoid base kinase inhibitors;   sphingosine kinase (phosphorylating) inhibitor;   sphingosine kinase (phosphorylating) inhibitors
 xref: Wikipedia:Sphingosine_kinase



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N,N-dimethylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of ABL1 protein CTD PMID:21195056 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein] CTD PMID:15498114 NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein] CTD PMID:15498114 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G C5 complement C5 multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:21195056 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:21998146 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of MCL1 protein CTD PMID:21195056 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of PARP1 protein CTD PMID:21195056 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sphk1 sphingosine kinase 1 decreases activity
multiple interactions
decreases expression
ISO
EXP
N,N-dimethylsphingosine results in decreased activity of SPHK1 protein
N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased activity of SPHK1 protein]
N,N-dimethylsphingosine results in decreased expression of SPHK1 protein
CTD PMID:17065523 PMID:19284563 PMID:21195056 PMID:21998146 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        biochemical role 19515
          enzyme inhibitor 18723
            EC 2.* (transferase) inhibitor 14869
              EC 2.7.* (P-containing group transferase) inhibitor 14366
                EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor 1630
                  EC 2.7.1.91 (sphingosine kinase) inhibitor 10
                    (2R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol 0
                    MP-A08 0
                    N,N-dimethylsphingosine 10
                    N-(p-octylbenzoyl)-piperidin-4-ol 0
                    SLM6071469 0
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