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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N,N-dimethylsphingosine
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Accession:CHEBI:78759 term browser browse the term
Definition:A sphingoid that is sphingosine in which the two amino hydrogens are replaced by amino groups.
Synonyms:exact_synonym: (2S,3R,4E)-2-(dimethylamino)octadec-4-ene-1,3-diol
 related_synonym: Formula=C20H41NO2;   InChI=1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1;   InChIKey=YRXOQXUDKDCXME-YIVRLKKSSA-N;   N,N-Dimethyl-D-erythro-sphingosine;   N,N-dimethylsphing-4-enine;   SMILES=CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@H](CO)N(C)C
 xref: CAS:122314-67-4;   HMDB:HMDB0013645;   KEGG:C13914;   LIPID_MAPS_instance:LMSP01070001
 xref_mesh: MESH:C061800
 xref: Reaxys:8057448;   Wikipedia:N\,N-Dimethylsphingosine


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N,N-dimethylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of ABL1 protein CTD PMID:21195056 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein] CTD PMID:15498114 NCBI chr 1:250,557,042...250,665,083
Ensembl chr 1:250,557,044...250,630,677
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein] CTD PMID:15498114 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G C5 complement C5 multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:21195056 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:21998146 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of MCL1 protein CTD PMID:21195056 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of PARP1 protein CTD PMID:21195056 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sphk1 sphingosine kinase 1 decreases activity
decreases expression
multiple interactions
ISO
EXP
N,N-dimethylsphingosine results in decreased activity of SPHK1 protein
N,N-dimethylsphingosine results in decreased expression of SPHK1 protein
N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased activity of SPHK1 protein]
CTD PMID:17065523, PMID:19284563, PMID:21195056, PMID:21998146 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link

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  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            N,N-dimethylsphingosine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17243
                                  azane 16960
                                    ammonia 16959
                                      organic amino compound 16958
                                        amino alcohol 883
                                          aminodiol 153
                                            2-aminooctadecene-1,3-diol 112
                                              2-aminooctadec-4-ene-1,3-diol 112
                                                sphing-4-enine 112
                                                  sphingosine 112
                                                    N,N-dimethylsphingosine 10
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