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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N,N-dimethylsphingosine
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Accession:CHEBI:78759 term browser browse the term
Definition:A sphingoid that is sphingosine in which the two amino hydrogens are replaced by amino groups.
Synonyms:exact_synonym: (2S,3R,4E)-2-(dimethylamino)octadec-4-ene-1,3-diol
 related_synonym: Formula=C20H41NO2;   InChI=1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1;   InChIKey=YRXOQXUDKDCXME-YIVRLKKSSA-N;   N,N-Dimethyl-D-erythro-sphingosine;   N,N-dimethylsphing-4-enine;   SMILES=CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@H](CO)N(C)C
 xref: CAS:122314-67-4;   HMDB:HMDB0013645;   KEGG:C13914;   LIPID_MAPS_instance:LMSP01070001
 xref_mesh: MESH:C061800
 xref: Reaxys:8057448;   Wikipedia:N\,N-Dimethylsphingosine


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N,N-dimethylsphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of ABL1 protein CTD PMID:21195056 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein] CTD PMID:15498114 NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein] CTD PMID:15498114 NCBI chr13:22,689,783...22,853,920 JBrowse link
G C5 complement C5 multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:21195056 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:21998146 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of MCL1 protein CTD PMID:21195056 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of PARP1 protein CTD PMID:21195056 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sphk1 sphingosine kinase 1 decreases activity
decreases expression
multiple interactions
ISO
EXP
N,N-dimethylsphingosine results in decreased activity of SPHK1 protein
N,N-dimethylsphingosine results in decreased expression of SPHK1 protein
N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased activity of SPHK1 protein]
CTD PMID:17065523 PMID:19284563 PMID:21195056 PMID:21998146 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link

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  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            N,N-dimethylsphingosine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        amino alcohol 1032
                                          aminodiol 162
                                            2-aminooctadecene-1,3-diol 116
                                              2-aminooctadec-4-ene-1,3-diol 116
                                                sphing-4-enine 116
                                                  sphingosine 116
                                                    N,N-dimethylsphingosine 10
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