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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxidopamine
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Accession:CHEBI:78741 term browser browse the term
Definition:A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Synonyms:exact_synonym: 5-(2-aminoethyl)benzene-1,2,4-triol
 related_synonym: 2,4,5-trihydroxyphenethylamine;   6-OHDA;   6-hydroxydopamine;   Formula=C8H11NO3;   InChI=1S/C8H11NO3/c9-2-1-5-3-7(11)8(12)4-6(5)10/h3-4,10-12H,1-2,9H2;   InChIKey=DIVDFFZHCJEHGG-UHFFFAOYSA-N;   SMILES=NCCc1cc(O)c(O)cc1O;   hydroxydopamine;   oxidopamina;   oxidopaminum;   topamine
 xref: HMDB:HMDB0001537;   KEGG:D05294;   LINCS:LSM-37081
 xref_mesh: MESH:D016627
 xref: MetaCyc:CPD-7666;   PMID:12486162;   PMID:22789904;   PMID:23358137;   PMID:23670213;   PMID:23959789;   PMID:24277157;   PMID:24333330;   PMID:24885281;   PMID:8255370;   Reaxys:2211011;   Wikipedia:Oxidopamine


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oxidopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 increases expression EXP Oxidopamine results in increased expression of ABCC8 mRNA; Oxidopamine results in increased expression of ABCC8 protein CTD PMID:15857625 NCBI chr 1:96,598,663...96,679,495
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 increases expression EXP Oxidopamine results in increased expression of ABCC9 mRNA; Oxidopamine results in increased expression of ABCC9 protein CTD PMID:15857625 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356 		JBrowse link
G Aco1 aconitase 1 increases expression
multiple interactions
affects response to substance		 ISO Oxidopamine results in increased expression of ACO1 mRNA
[ACO1 protein affects the susceptibility to Oxidopamine] which results in decreased expression of HEPH mRNA; Oxidopamine promotes the reaction [ACO1 protein results in decreased expression of SLC40A1 mRNA]		 CTD PMID:19913091 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Adora2a adenosine A2a receptor multiple interactions EXP 8-(3-chlorostyryl)caffeine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein]; [Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A mRNA; [Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein CTD PMID:15065221 PMID:21195062 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Ager advanced glycosylation end product-specific receptor affects expression
affects binding		 EXP Oxidopamine affects the expression of AGER protein
Oxidopamine binds to AGER protein		 CTD PMID:26902637 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
increases expression
affects localization		 ISO
EXP		 alpha-iso-cubebenol inhibits the reaction [Oxidopamine affects the localization of AIFM1 protein]; Selegiline inhibits the reaction [Oxidopamine affects the localization of AIFM1 protein]
Oxidopamine results in increased expression of AIFM1 protein		 CTD PMID:12880480 PMID:24997245 PMID:31022188 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO Oxidopamine results in increased expression of AKR1C3 mRNA; Oxidopamine results in increased expression of AKR1C3 protein CTD PMID:33486071 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
affects phosphorylation
decreases phosphorylation		 EXP
ISO		 Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT1 protein]; Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT1 protein]; Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT1 protein]; Oxidopamine results in increased phosphorylation of and results in increased activity of AKT1 protein
2-chloro-5-hydroxyphenylglycine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of AKT1 protein]; 2-chloro-5-hydroxyphenylglycine affects the reaction [Oxidopamine affects the phosphorylation of AKT1 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of AKT1 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [Oxidopamine affects the phosphorylation of AKT1 protein]; [GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of AKT1 protein		 CTD PMID:16339297 PMID:21397656 PMID:33571554 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions
decreases phosphorylation		 EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein]; Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein]; Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein] CTD PMID:16339297 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 multiple interactions
decreases phosphorylation		 EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein]; Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein]; Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein] CTD PMID:16339297 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Atf4 activating transcription factor 4 increases expression
multiple interactions		 EXP Oxidopamine results in increased expression of ATF4 mRNA; Oxidopamine results in increased expression of ATF4 protein
Resveratrol inhibits the reaction [Oxidopamine results in increased expression of ATF4 protein]		 CTD PMID:12486162 PMID:34302886 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atxn2 ataxin 2 multiple interactions
increases expression		 EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of ATXN2 mRNA]; Levodopa inhibits the reaction [Oxidopamine results in increased expression of ATXN2 mRNA]; Rutin inhibits the reaction [Oxidopamine results in increased expression of ATXN2 mRNA] CTD PMID:25129099 NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479 		JBrowse link
G Atxn3 ataxin 3 multiple interactions
increases expression		 EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of ATXN3 mRNA]; Levodopa inhibits the reaction [Oxidopamine results in increased expression of ATXN3 mRNA]; Rutin inhibits the reaction [Oxidopamine results in increased expression of ATXN3 mRNA] CTD PMID:25129099 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902 		JBrowse link
G Avpr2 arginine vasopressin receptor 2 increases expression EXP Oxidopamine results in increased expression of AVPR2 mRNA CTD PMID:15303306 NCBI chr  X:151,633,501...151,636,000
Ensembl chr  X:151,633,522...151,635,989 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
increases expression
multiple interactions		 ISO
EXP		 Oxidopamine affects the localization of BAX protein
Oxidopamine results in increased expression of BAX mRNA; Oxidopamine results in increased expression of BAX protein
tricetin inhibits the reaction [Oxidopamine results in increased expression of BAX mRNA]; tricetin inhibits the reaction [Oxidopamine results in increased expression of BAX protein]; Valproic Acid inhibits the reaction [Oxidopamine results in increased expression of BAX protein]
5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Oxidopamine results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Oxidopamine results in increased expression of BAX protein]; Tea inhibits the reaction [Oxidopamine results in increased expression of BAX protein]		 CTD PMID:16480889 PMID:21397656 PMID:22821850 PMID:28802652 PMID:31176653 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO
EXP		 PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]]; pyrazolanthrone inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; SB 203580 inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; tricetin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 mRNA]; tricetin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]
[2-chloro-5-hydroxyphenylglycine co-treated with Oxidopamine] results in decreased expression of BCL2 protein; [6-methyl-2-(phenylethynyl)pyridine co-treated with Oxidopamine] results in decreased expression of BCL2 protein
5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; Tea inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]
Oxidopamine results in decreased expression of BCL2 mRNA; Oxidopamine results in decreased expression of BCL2 protein		 CTD PMID:16480889 PMID:21397656 PMID:25446857 PMID:28802652 PMID:30707903 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions		 ISO Oxidopamine results in decreased expression of BDNF protein
chrysin inhibits the reaction [Oxidopamine results in decreased expression of BDNF protein]		 CTD PMID:29054324 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Calr calreticulin increases expression EXP Oxidopamine results in increased expression of CALR mRNA CTD PMID:12486162 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Casp1 caspase 1 increases expression
multiple interactions		 EXP Oxidopamine results in increased expression of CASP1 mRNA
Levodopa inhibits the reaction [Oxidopamine results in increased expression of CASP1 mRNA]		 CTD PMID:25129099 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 increases cleavage
multiple interactions		 EXP Oxidopamine results in increased cleavage of CASP12 protein
Resveratrol inhibits the reaction [Oxidopamine results in increased cleavage of CASP12 protein]		 CTD PMID:34302886 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 increases activity
affects activity
increases expression
increases cleavage
multiple interactions		 ISO
EXP		 Oxidopamine results in increased activity of CASP3 protein
Oxidopamine affects the activity of CASP3 protein
Oxidopamine results in increased expression of CASP3 mRNA; Oxidopamine results in increased expression of CASP3 protein modified form
Oxidopamine results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [Oxidopamine results in increased expression of CASP3 protein modified form]; 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; Emodin inhibits the reaction [Oxidopamine results in decreased expression of and results in increased cleavage of CASP3 protein]; Emodin inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; Levodopa inhibits the reaction [Oxidopamine results in increased expression of CASP3 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; MDL 201053 inhibits the reaction [Oxidopamine results in increased expression of CASP3 protein modified form]; MIR107 mRNA affects the reaction [Oxidopamine affects the activity of CASP3 protein]; Oxidopamine results in decreased expression of and results in increased cleavage of CASP3 protein; Resveratrol inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Oxidopamine results in increased expression of CASP3 mRNA]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]
sulforaphane inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]
Caffeine inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; ginsenoside Rb1 inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; MIR107 mRNA affects the reaction [Oxidopamine affects the activity of CASP3 protein]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; Oxidopamine results in increased expression of and results in increased activity of CASP3 protein; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; pinostilbene inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; Plant Extracts inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; puag-haad inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]; Resveratrol inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]; sulforaphane inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; tricetin inhibits the reaction [Oxidopamine results in increased expression of and results in increased activity of CASP3 protein]; Valproic Acid inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]		 CTD PMID:18201823 PMID:18675900 PMID:19443200 PMID:19780897 PMID:19781563 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases cleavage
increases expression		 EXP
ISO		 Levodopa inhibits the reaction [Oxidopamine results in increased expression of CASP7 mRNA]; Rutin inhibits the reaction [Oxidopamine results in increased expression of CASP7 mRNA]
Valproic Acid inhibits the reaction [Oxidopamine results in increased cleavage of CASP7 protein]		 CTD PMID:25129099 PMID:32167238 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage
multiple interactions		 ISO
EXP		 Oxidopamine results in increased activity of CASP9 protein
Oxidopamine results in increased cleavage of CASP9 protein
sulforaphane inhibits the reaction [Oxidopamine results in increased activity of CASP9 protein]; Valproic Acid inhibits the reaction [Oxidopamine results in increased cleavage of CASP9 protein]		 CTD PMID:19780897 PMID:19781563 PMID:21846476 PMID:32167238 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 EXP Oxidopamine results in decreased activity of CAT protein
Tea inhibits the reaction [Oxidopamine results in decreased activity of CAT protein]		 CTD PMID:16480889 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cd2ap CD2-associated protein increases expression ISO Oxidopamine results in increased expression of CD2AP mRNA CTD PMID:18535749 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 multiple interactions EXP [Oxidopamine co-treated with Levodopa] results in increased expression of CDK5 protein CTD PMID:17188499 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression EXP Oxidopamine results in increased expression of CEBPB mRNA CTD PMID:12486162 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance ISO CNR1 affects the susceptibility to Oxidopamine CTD PMID:19419794 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of Oxidopamine CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
increases expression		 ISO N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Oxidopamine results in increased expression of CYBB protein] CTD PMID:17855475 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cycs cytochrome c, somatic increases expression EXP Oxidopamine results in increased expression of CYCS protein CTD PMID:31022188 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Ddc dopa decarboxylase decreases expression
multiple interactions		 EXP Oxidopamine results in decreased expression of DDC protein
Levodopa inhibits the reaction [Oxidopamine results in decreased expression of DDC protein]		 CTD PMID:20232137 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 EXP
ISO		 Oxidopamine results in increased expression of DDIT3 mRNA; Oxidopamine results in increased expression of DDIT3 protein
Resveratrol inhibits the reaction [Oxidopamine results in increased expression of DDIT3 protein]; sodium bisulfide inhibits the reaction [Oxidopamine results in increased expression of DDIT3 protein]		 CTD PMID:12486162 PMID:32870474 PMID:33961902 PMID:34302886 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 affects localization
decreases expression
multiple interactions		 EXP Oxidopamine affects the localization of DLG1 protein
Oxidopamine results in decreased expression of DLG1 protein
[Oxidopamine co-treated with Levodopa] results in increased expression of DLG1 mRNA; [Oxidopamine co-treated with Levodopa] results in increased expression of DLG1 protein		 CTD PMID:15703272 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions
decreases expression
affects localization		 EXP [Oxidopamine co-treated with Levodopa] results in increased expression of DLG4 mRNA; [Oxidopamine co-treated with Levodopa] results in increased expression of DLG4 protein; Resveratrol inhibits the reaction [Oxidopamine results in decreased expression of DLG4 protein]
Oxidopamine results in decreased expression of DLG4 mRNA; Oxidopamine results in decreased expression of DLG4 protein
Oxidopamine affects the localization of DLG4 protein		 CTD PMID:15703272 PMID:34302886 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 increases expression EXP Oxidopamine results in increased expression of DNAJA2 mRNA CTD PMID:12486162 NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 increases degradation
decreases expression		 EXP
ISO		 Oxidopamine results in increased degradation of DNAJA3 protein
Oxidopamine results in decreased expression of DNAJA3 protein		 CTD PMID:22016808 NCBI chr10:10,855,510...10,880,175
Ensembl chr10:10,854,732...10,880,161 		JBrowse link
G Dnm1l dynamin 1-like affects localization
increases expression
multiple interactions		 ISO Oxidopamine affects the localization of DNM1L protein
Oxidopamine results in increased expression of DNM1L protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Oxidopamine affects the localization of DNM1L protein]		 CTD PMID:22821850 PMID:31705926 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
increases expression
decreases expression		 EXP [Levodopa co-treated with Oxidopamine] results in increased expression of DRD1 mRNA; [Oxidopamine co-treated with levodopa methyl ester] promotes the reaction [Benserazide results in increased expression of DRD1 protein]; Levodopa inhibits the reaction [Oxidopamine results in decreased expression of DRD1 protein]
Oxidopamine results in increased expression of DRD1 protein
Oxidopamine results in decreased expression of DRD1 mRNA; Oxidopamine results in decreased expression of DRD1 protein		 CTD PMID:16365282 PMID:18707801 PMID:19118628 PMID:19399396 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
increases expression		 EXP [Oxidopamine co-treated with levodopa methyl ester] inhibits the reaction [Benserazide results in increased expression of DRD2 protein]; Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]; Tea inhibits the reaction [Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]]
Oxidopamine results in increased expression of DRD2 mRNA; Oxidopamine results in increased expression of DRD2 protein		 CTD PMID:16480889 PMID:19118628 PMID:19399396 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 multiple interactions
decreases expression		 EXP [Levodopa co-treated with Oxidopamine] results in increased expression of DRD3 mRNA; [Levodopa co-treated with Oxidopamine] results in increased expression of DRD3 protein; Oxidopamine inhibits the reaction [7-hydroxy-2-N,N-dipropylaminotetralin binds to DRD3 protein]
Oxidopamine results in decreased expression of DRD3 mRNA		 CTD PMID:7878047 PMID:17241287 PMID:19118628 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Drd4 dopamine receptor D4 increases expression EXP Oxidopamine results in increased expression of DRD4 mRNA CTD PMID:15303306 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Egf epidermal growth factor decreases activity EXP Oxidopamine results in decreased activity of EGF protein CTD PMID:9324159 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions
increases expression		 EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA]; Levodopa inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA]; Rutin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA] CTD PMID:25129099 NCBI chr19:52,867,914...52,907,169
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP [Oxidopamine co-treated with Levodopa] results in increased expression of EGR1 mRNA CTD PMID:9890435 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions EXP Oxidopamine results in increased phosphorylation of and results in increased activity of EIF2A protein CTD PMID:12486162 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 affects response to substance
multiple interactions		 ISO
EXP		 EIF2AK3 protein affects the susceptibility to Oxidopamine
Oxidopamine results in increased phosphorylation of and results in increased activity of EIF2AK3 protein		 CTD PMID:12486162 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G En1 engrailed homeobox 1 multiple interactions ISO [EN1 protein co-treated with EN2 protein] results in decreased susceptibility to Oxidopamine CTD PMID:21892157 NCBI chr13:31,750,892...31,756,477
Ensembl chr13:31,751,545...31,755,943 		JBrowse link
G En2 engrailed homeobox 2 multiple interactions ISO [EN1 protein co-treated with EN2 protein] results in decreased susceptibility to Oxidopamine CTD PMID:21892157 NCBI chr 4:7,221,096...7,226,943
Ensembl chr 4:7,221,096...7,226,943 		JBrowse link
G Ephb1 Eph receptor B1 decreases expression ISO Oxidopamine results in decreased expression of EPHB1 protein CTD PMID:11146119 NCBI chr 8:102,507,549...102,944,839
Ensembl chr 8:102,507,549...102,944,839 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Oxidopamine results in increased phosphorylation of and results in increased activity of ERN1 protein CTD PMID:12486162 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Esr1 estrogen receptor 1 increases expression EXP Oxidopamine results in increased expression of ESR1 mRNA CTD PMID:12486162 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fgf10 fibroblast growth factor 10 increases expression EXP Oxidopamine results in increased expression of FGF10 mRNA CTD PMID:15303306 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fibin fin bud initiation factor homolog increases expression ISO Oxidopamine results in increased expression of FIBIN mRNA CTD PMID:32870474 NCBI chr 3:96,942,405...96,944,676
Ensembl chr 3:96,942,406...96,944,676 		JBrowse link
G Fis1 fission, mitochondrial 1 increases expression
multiple interactions		 ISO Oxidopamine results in increased expression of FIS1 protein
salvin inhibits the reaction [Oxidopamine results in increased expression of FIS1 protein]		 CTD PMID:31705926 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression		 EXP [Levodopa co-treated with Oxidopamine] results in increased expression of FOS protein; [Oxidopamine co-treated with Levodopa] results in increased expression of FOS mRNA; [Oxidopamine co-treated with Levodopa] results in increased expression of FOS protein; GDNF protein inhibits the reaction [Oxidopamine inhibits the reaction [Amphetamine results in increased expression of FOS protein]]; Oxidopamine inhibits the reaction [Amphetamine results in increased expression of FOS protein]
Oxidopamine results in decreased expression of FOS protein		 CTD PMID:11031079 PMID:14526427 PMID:16325000 PMID:16706847 PMID:17329435 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO
EXP		 [Levodopa co-treated with Oxidopamine] results in increased expression of FOSB protein; [Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein
Oxidopamine results in increased expression of FOSB protein
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[Levodopa co-treated with Oxidopamine] results in increased expression of FOSB protein]; [Levodopa co-treated with Oxidopamine] results in increased expression of FOSB protein; [Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein; [TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein]; Levodopa promotes the reaction [Oxidopamine results in increased expression of FOSB protein]		 CTD PMID:12127155 PMID:15207268 PMID:15659429 PMID:16095907 PMID:16139809 More... NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions
increases expression		 EXP 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of GAD1 mRNA]]; Levodopa inhibits the reaction [Oxidopamine results in increased expression of GAD1 mRNA]; Levodopa promotes the reaction [Oxidopamine results in increased expression of GAD1 mRNA] CTD PMID:12077209 PMID:15044549 PMID:15610165 PMID:17241287 PMID:19660528 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 multiple interactions
increases expression		 EXP Levodopa promotes the reaction [Oxidopamine results in increased expression of GAD2 mRNA] CTD PMID:19660528 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Galr2 galanin receptor 2 decreases expression
increases expression		 EXP Oxidopamine results in decreased expression of GALR2 mRNA
Oxidopamine results in increased expression of GALR2 mRNA		 CTD PMID:15303306 PMID:15518916 NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176 		JBrowse link
G Gch1 GTP cyclohydrolase 1 multiple interactions EXP [TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein]; [TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]; [TH co-treated with GCH1] inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of PENK mRNA]] CTD PMID:15659429 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression
multiple interactions
increases expression		 ISO
EXP		 Oxidopamine results in decreased expression of GCLC protein
salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein]
Oxidopamine results in increased expression of GCLC mRNA; Oxidopamine results in increased expression of GCLC protein		 CTD PMID:21397656 PMID:25446857 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases expression
increases expression
multiple interactions		 ISO
EXP		 Oxidopamine results in decreased expression of GCLM protein
Oxidopamine results in increased expression of GCLM mRNA
salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein]
AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein]		 CTD PMID:25446857 PMID:33486071 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdnf glial cell derived neurotrophic factor affects response to substance
decreases expression
multiple interactions		 ISO
EXP		 GDNF protein affects the susceptibility to Oxidopamine
Oxidopamine results in decreased expression of GDNF protein
chrysin inhibits the reaction [Oxidopamine results in decreased expression of GDNF protein]
GDNF protein affects the susceptibility to [Apomorphine co-treated with Oxidopamine]; GDNF protein affects the susceptibility to [Dextroamphetamine co-treated with Oxidopamine]; GDNF protein affects the susceptibility to [Oxidopamine co-treated with Amphetamine]; GDNF protein affects the susceptibility to [Oxidopamine co-treated with Dextroamphetamine]; GDNF protein inhibits the reaction [Oxidopamine inhibits the reaction [Amphetamine results in increased expression of FOS protein]]
GDNF protein inhibits the reaction [Oxidopamine results in decreased secretion of Dopamine]		 CTD PMID:11031079 PMID:11312561 PMID:11771942 PMID:12213621 PMID:12429192 More... NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression
multiple interactions		 EXP Oxidopamine results in decreased expression of GFAP protein
Oxidopamine results in increased expression of GFAP protein
Resveratrol inhibits the reaction [Oxidopamine results in increased expression of GFAP protein]; Rosiglitazone promotes the reaction [Oxidopamine results in increased expression of GFAP protein]		 CTD PMID:22842585 PMID:24486959 PMID:34302886 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gopc golgi associated PDZ and coiled-coil motif containing affects expression
multiple interactions
affects response to substance		 EXP
ISO		 Oxidopamine affects the expression of GOPC protein
2-chloro-5-hydroxyphenylglycine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein]; [GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein
2-chloro-5-hydroxyphenylglycine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of AKT1 protein]; 2-chloro-5-hydroxyphenylglycine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK1 protein]; 2-chloro-5-hydroxyphenylglycine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK3 protein]; 2-chloro-5-hydroxyphenylglycine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK8 protein]; 2-chloro-5-hydroxyphenylglycine affects the reaction [Oxidopamine affects the expression of GOPC protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of AKT1 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK3 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK8 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [Oxidopamine affects the expression of GOPC protein]; [GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of AKT1 protein; [GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK1 protein; [GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK3 protein; [GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK8 protein; GOPC protein affects the reaction [2-chloro-5-hydroxyphenylglycine affects the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; GOPC protein affects the reaction [6-methyl-2-(phenylethynyl)pyridine promotes the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; GOPC protein affects the reaction [Oxidopamine results in increased cleavage of PARP1 protein]		 CTD PMID:33571554 NCBI chr20:31,727,617...31,776,928
Ensembl chr20:31,727,620...31,776,903 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression EXP Oxidopamine results in decreased expression of GRIA2 mRNA CTD PMID:11290405 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression
multiple interactions		 EXP Oxidopamine results in decreased expression of GRIN1 mRNA; Oxidopamine results in decreased expression of GRIN1 protein alternative form
Levodopa inhibits the reaction [Oxidopamine results in decreased expression of GRIN1 protein alternative form]		 CTD PMID:15518916 PMID:16365282 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
decreases expression		 EXP Levodopa inhibits the reaction [Oxidopamine results in decreased expression of GRIN2B protein] CTD PMID:16365282 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions ISO [benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of GRM1 protein CTD PMID:17596448 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170 		JBrowse link
G Grm5 glutamate metabotropic receptor 5 affects expression ISO
EXP		 Oxidopamine affects the expression of GRM5 protein CTD PMID:33571554 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274 		JBrowse link
G Gsr glutathione-disulfide reductase decreases expression
multiple interactions
decreases activity		 ISO
EXP		 Oxidopamine results in decreased expression of GSR protein
salvin inhibits the reaction [Oxidopamine results in decreased expression of GSR protein]
sulforaphane inhibits the reaction [Oxidopamine results in decreased activity of GSR protein]		 CTD PMID:23518299 PMID:25446857 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases expression		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein] CTD PMID:25271104 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hax1 HCLS1 associated protein X-1 increases expression ISO Oxidopamine results in increased expression of HAX1 protein CTD PMID:19763263 NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714 		JBrowse link
G Heph hephaestin decreases expression
multiple interactions		 ISO Oxidopamine results in decreased expression of HEPH mRNA; Oxidopamine results in decreased expression of HEPH protein
[ACO1 protein affects the susceptibility to Oxidopamine] which results in decreased expression of HEPH mRNA; [IREB2 protein affects the susceptibility to Oxidopamine] which results in decreased expression of HEPH mRNA		 CTD PMID:19913091 NCBI chr  X:61,151,131...61,402,980
Ensembl chr  X:61,296,345...61,402,980 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression EXP Oxidopamine results in increased expression of HERPUD1 mRNA CTD PMID:12486162 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 affects expression
multiple interactions		 EXP
ISO		 Oxidopamine affects the expression of HES1 protein
MIR107 mRNA affects the reaction [Oxidopamine affects the expression of HES1 protein]; PDCD10 protein affects the reaction [MIR107 mRNA affects the reaction [Oxidopamine affects the expression of HES1 protein]]		 CTD PMID:31778666 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression		 ISO
EXP		 AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]; N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Oxidopamine results in decreased expression of HMOX1 protein]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]]
Oxidopamine results in increased expression of HMOX1 mRNA; Oxidopamine results in increased expression of HMOX1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein]; [5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride results in decreased abundance of Peroxynitrous Acid] inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein]; U 0126 inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein]		 CTD PMID:17676812 PMID:17855475 PMID:21397656 PMID:33486071 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases expression ISO Oxidopamine results in increased expression of HPGD mRNA CTD PMID:31247335 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression EXP Oxidopamine results in increased expression of HSP90AB1 mRNA CTD PMID:12486162 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression EXP Oxidopamine results in increased expression of HSP90B1 mRNA CTD PMID:12486162 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like increases expression EXP Oxidopamine results in increased expression of HSPA1L mRNA CTD PMID:12486162 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression EXP Oxidopamine results in increased expression of HSPA4 mRNA CTD PMID:12486162 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 EXP Oxidopamine results in increased expression of HSPA5 mRNA; Oxidopamine results in increased expression of HSPA5 protein
Resveratrol inhibits the reaction [Oxidopamine results in increased expression of HSPA5 protein]; sodium bisulfide inhibits the reaction [Oxidopamine results in increased expression of HSPA5 protein]		 CTD PMID:12486162 PMID:33961902 PMID:34302886 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO
EXP		 Oxidopamine results in increased expression of HSPA8 mRNA CTD PMID:12486162 PMID:19763263 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression EXP Oxidopamine results in increased expression of HSPB1 mRNA CTD PMID:12486162 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP Oxidopamine results in increased expression of HSPE1 mRNA CTD PMID:12486162 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression
multiple interactions		 EXP Oxidopamine results in decreased expression of HTR1A mRNA
stepholidine inhibits the reaction [Oxidopamine results in decreased expression of HTR1A mRNA]		 CTD PMID:18707801 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htra2 HtrA serine peptidase 2 increases expression ISO Oxidopamine results in increased expression of HTRA2 mRNA; Oxidopamine results in increased expression of HTRA2 protein CTD PMID:19763263 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Oxidopamine inhibits the reaction [Freund's Adjuvant results in increased expression of ICAM1] CTD PMID:20600813 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO Oxidopamine results in decreased expression of IDH3A mRNA CTD PMID:19763263 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084 		JBrowse link
G Ifng interferon gamma increases expression
multiple interactions		 ISO Oxidopamine results in increased expression of IFNG protein
chrysin inhibits the reaction [Oxidopamine results in increased expression of IFNG protein]		 CTD PMID:29054324 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression		 ISO chrysin inhibits the reaction [Oxidopamine results in decreased expression of IL10 protein] CTD PMID:29054324 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO
EXP		 chrysin inhibits the reaction [Oxidopamine results in increased expression of IL1B protein]
Resveratrol inhibits the reaction [Oxidopamine results in increased expression of IL1B protein]		 CTD PMID:29054324 PMID:34302886 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 increases expression ISO Oxidopamine results in increased expression of IL2 protein CTD PMID:29054324 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Oxidopamine results in increased expression of IL6 protein
chrysin inhibits the reaction [Oxidopamine results in increased expression of IL6 protein]		 CTD PMID:29054324 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ireb2 iron responsive element binding protein 2 increases expression
multiple interactions		 ISO Oxidopamine results in increased expression of IREB2 mRNA
[IREB2 protein affects the susceptibility to Oxidopamine] which results in decreased expression of HEPH mRNA; Oxidopamine promotes the reaction [IREB2 protein results in decreased expression of SLC40A1 mRNA]		 CTD PMID:19913091 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation		 ISO Apomorphine inhibits the reaction [Oxidopamine results in increased phosphorylation of JUN protein]; pinostilbene inhibits the reaction [Oxidopamine results in increased phosphorylation of JUN protein]; puag-haad inhibits the reaction [Oxidopamine results in increased phosphorylation of JUN protein]
Acetylcysteine inhibits the reaction [Oxidopamine promotes the reaction [MAPK8 protein binds to and results in increased phosphorylation of JUN protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Oxidopamine promotes the reaction [MAPK8 protein binds to and results in increased phosphorylation of JUN protein]]; Oxidopamine promotes the reaction [MAPK8 protein binds to and results in increased phosphorylation of JUN protein]		 CTD PMID:10397638 PMID:14599342 PMID:18675900 PMID:19443200 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Oxidopamine co-treated with Levodopa] results in increased expression of JUNB mRNA; Dizocilpine Maleate inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of JUNB mRNA]; eticlopride affects the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of JUNB mRNA]; Oxidopamine results in increased localization of and results in increased activity of JUNB protein CTD PMID:9890435 PMID:17368433 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 increases expression EXP Oxidopamine results in increased expression of KCNJ11 mRNA; Oxidopamine results in increased expression of KCNJ11 protein CTD PMID:15857625 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 increases expression EXP Oxidopamine results in increased expression of KCNJ8 mRNA; Oxidopamine results in increased expression of KCNJ8 protein CTD PMID:15857625 NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects response to substance ISO KEAP1 mRNA affects the susceptibility to Oxidopamine CTD PMID:16092930 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Lonp1 lon peptidase 1, mitochondrial increases expression EXP Oxidopamine results in increased expression of LONP1 mRNA CTD PMID:12486162 NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression EXP Oxidopamine results in increased expression of MAP1LC3B protein modified form CTD PMID:28802652 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
affects phosphorylation
multiple interactions		 ISO
EXP		 Oxidopamine results in increased phosphorylation of MAPK1 protein
Oxidopamine affects the phosphorylation of MAPK1 protein
Oxidopamine results in increased phosphorylation of and results in increased activity of MAPK1 protein
2-chloro-5-hydroxyphenylglycine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK1 protein]; 2-chloro-5-hydroxyphenylglycine affects the reaction [Oxidopamine affects the phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [Oxidopamine affects the phosphorylation of MAPK1 protein]; [benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of MAPK1 protein; [GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK1 protein; [Levodopa co-treated with Oxidopamine] results in increased phosphorylation of MAPK1 protein; [Oxidopamine co-treated with Levodopa] results in increased expression of MAPK1 protein; [Oxidopamine co-treated with Levodopa] results in increased phosphorylation of MAPK1 protein; SCH 23390 inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of MAPK1 protein]; SL 327 inhibits the reaction [[benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of MAPK1 protein]; sulforaphane inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK1 protein]; AL 8810 inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK1 protein]; alpha-iso-cubebenol inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK1 protein]; fluprostenol promotes the reaction [Oxidopamine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:16139809 PMID:17596448 PMID:19187092 PMID:19520364 PMID:21397656 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
affects phosphorylation
increases phosphorylation		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK3 protein]; AL 8810 inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK3 protein]; alpha-iso-cubebenol inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK3 protein]; fluprostenol promotes the reaction [Oxidopamine results in increased phosphorylation of MAPK3 protein]
Oxidopamine affects the phosphorylation of MAPK3 protein
Oxidopamine results in increased phosphorylation of and results in increased activity of MAPK3 protein
2-chloro-5-hydroxyphenylglycine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK3 protein]; 2-chloro-5-hydroxyphenylglycine affects the reaction [Oxidopamine affects the phosphorylation of MAPK3 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK3 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [Oxidopamine affects the phosphorylation of MAPK3 protein]; [benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of MAPK3 protein; [GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK3 protein; [Levodopa co-treated with Oxidopamine] results in increased phosphorylation of MAPK3 protein; [Oxidopamine co-treated with Levodopa] results in increased expression of MAPK3 protein; [Oxidopamine co-treated with Levodopa] results in increased phosphorylation of MAPK3 protein; SCH 23390 inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of MAPK3 protein]; SL 327 inhibits the reaction [[benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of MAPK3 protein]; sulforaphane inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK3 protein]		 CTD PMID:16139809 PMID:17596448 PMID:19187092 PMID:19520364 PMID:21397656 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO
EXP		 Oxidopamine results in increased phosphorylation of MAPK8 protein
salvin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein]
puag-haad inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein]; tricetin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein]
2-chloro-5-hydroxyphenylglycine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK8 protein]; 2-chloro-5-hydroxyphenylglycine promotes the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK8 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein]; [GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK8 protein; Acetylcysteine inhibits the reaction [Oxidopamine promotes the reaction [MAPK8 protein binds to and results in increased phosphorylation of JUN protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Oxidopamine promotes the reaction [MAPK8 protein binds to and results in increased phosphorylation of JUN protein]]; Oxidopamine promotes the reaction [MAPK8 protein binds to and results in increased phosphorylation of JUN protein]		 CTD PMID:10397638 PMID:18675900 PMID:25446857 PMID:31176653 PMID:33571554 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions		 ISO
EXP		 Oxidopamine results in increased phosphorylation of MAPK9 protein
salvin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK9 protein]
puag-haad inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK9 protein]		 CTD PMID:18675900 PMID:25446857 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP Oxidopamine results in increased cleavage of and results in decreased phosphorylation of MAPT protein CTD PMID:12686375 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions
decreases expression		 ISO salvin inhibits the reaction [Oxidopamine results in decreased expression of MFN2 protein] CTD PMID:31705926 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mir107 microRNA 107 decreases expression
multiple interactions		 ISO
EXP		 Oxidopamine results in decreased expression of MIR107 mRNA
MIR107 mRNA affects the reaction [Oxidopamine affects the activity of CASP3 protein]; MIR107 mRNA affects the reaction [Oxidopamine affects the expression of HES1 protein]; MIR107 mRNA affects the reaction [Oxidopamine affects the expression of NOTCH1 protein]; PDCD10 protein affects the reaction [MIR107 mRNA affects the reaction [Oxidopamine affects the expression of HES1 protein]]; PDCD10 protein affects the reaction [MIR107 mRNA affects the reaction [Oxidopamine affects the expression of NOTCH1 protein]]
[Oxidopamine affects the reaction [MIR107 mRNA binds to PDCD10 3' UTR]] which affects the expression of PDCD10 mRNA; [Oxidopamine affects the reaction [MIR107 mRNA binds to PDCD10 3' UTR]] which affects the expression of PDCD10 protein; MIR107 mRNA affects the reaction [Oxidopamine affects the activity of CASP3 protein]; MIR107 mRNA affects the reaction [Oxidopamine affects the expression of HES1 protein]; MIR107 mRNA affects the reaction [Oxidopamine affects the expression of NOTCH1 protein]; Oxidopamine affects the reaction [MIR107 mRNA binds to PDCD10 3' UTR]; PDCD10 protein affects the reaction [MIR107 mRNA affects the reaction [Oxidopamine affects the expression of HES1 protein]]; PDCD10 protein affects the reaction [MIR107 mRNA affects the reaction [Oxidopamine affects the expression of NOTCH1 protein]]		 CTD PMID:31778666 NCBI chr 1:232,337,767...232,337,853
Ensembl chr 1:232,337,767...232,337,853 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine results in increased expression of MMP9 mRNA]; Acetylcysteine inhibits the reaction [Oxidopamine results in increased expression of MMP9 mRNA]; SB 203580 inhibits the reaction [Oxidopamine results in increased expression of MMP9 mRNA] CTD PMID:19962414 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt1-ps3 metallothionein 1, pseudogene 3 increases expression ISO Oxidopamine results in increased expression of MT1E mRNA CTD PMID:32870474 NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135 		JBrowse link
G Mt2A metallothionein 2A decreases response to substance
increases expression		 EXP
ISO		 MT2A protein results in decreased susceptibility to Oxidopamine
Oxidopamine results in increased expression of MT2A mRNA		 CTD PMID:14604781 PMID:32870474 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Oxidopamine results in increased expression of MYC protein CTD PMID:17368433 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 decreases response to substance EXP NAIP protein results in decreased susceptibility to Oxidopamine CTD PMID:11553289 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization
decreases expression
increases localization
increases expression
increases activity
decreases response to substance		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine affects the localization of NFE2L2 protein]; [2-tert-butylhydroquinone results in increased expression of NFE2L2 protein] which results in decreased susceptibility to Oxidopamine; [linsidomine results in increased expression of NFE2L2 protein] which results in decreased susceptibility to Oxidopamine; AL 8810 inhibits the reaction [Oxidopamine affects the localization of NFE2L2 protein]
Oxidopamine results in decreased expression of NFE2L2 protein
Oxidopamine results in increased localization of NFE2L2 protein
Oxidopamine results in increased expression of NFE2L2 mRNA; Oxidopamine results in increased expression of NFE2L2 protein
Oxidopamine results in increased activity of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine results in increased expression of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine results in increased localization of NFE2L2 protein]
NFE2L2 protein results in decreased susceptibility to Oxidopamine		 CTD PMID:16092930 PMID:17676812 PMID:21397656 PMID:29057453 PMID:33486071 More... NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression
increases phosphorylation		 ISO Oxidopamine results in decreased expression of NFKBIA protein
Oxidopamine results in increased phosphorylation of NFKBIA protein		 CTD PMID:20851755 PMID:31247335 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor multiple interactions
decreases expression		 ISO chrysin inhibits the reaction [Oxidopamine results in decreased expression of NGF protein] CTD PMID:29054324 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases expression		 ISO N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Oxidopamine results in increased expression of NOS1 protein] CTD PMID:17855475 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 ISO
EXP		 Oxidopamine results in increased expression of NOS2 protein
[Oxidopamine results in increased expression of NOS2 protein] which results in increased secretion of Nitrites
N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Oxidopamine results in increased expression of NOS2 protein]		 CTD PMID:17855475 PMID:21397656 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Notch1 notch receptor 1 multiple interactions
affects expression		 ISO
EXP		 MIR107 mRNA affects the reaction [Oxidopamine affects the expression of NOTCH1 protein]; PDCD10 protein affects the reaction [MIR107 mRNA affects the reaction [Oxidopamine affects the expression of NOTCH1 protein]] CTD PMID:31778666 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Npy neuropeptide Y decreases expression
increases expression		 EXP Oxidopamine results in decreased expression of NPY protein
Oxidopamine results in increased expression of NPY mRNA		 CTD PMID:3805164 PMID:9460767 PMID:15303306 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 EXP
ISO		 Oxidopamine results in increased expression of NQO1 mRNA; Oxidopamine results in increased expression of NQO1 protein
AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]]		 CTD PMID:21397656 PMID:33486071 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase decreases expression
multiple interactions		 EXP Oxidopamine results in decreased expression of NSF mRNA
isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]; Levodopa inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]; Rutin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]		 CTD PMID:25129099 NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386 		JBrowse link
G Nsg1 neuronal vesicle trafficking associated 1 decreases expression
multiple interactions		 EXP Oxidopamine results in decreased expression of NSG1 mRNA
isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA]; Rutin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA]		 CTD PMID:25129099 NCBI chr14:72,648,771...72,670,521
Ensembl chr14:72,648,741...72,670,514 		JBrowse link
G Oma1 OMA1 zinc metallopeptidase multiple interactions
increases expression		 EXP Emodin inhibits the reaction [Oxidopamine results in increased expression of OMA1 protein] CTD PMID:34971761 NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions
decreases expression		 EXP
ISO		 isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]; Levodopa inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]; Rutin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]
Oxidopamine results in decreased expression of OPA1 protein
OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 protein]		 CTD PMID:25129099 PMID:31705926 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 decreases expression EXP Oxidopamine results in decreased expression of OPRL1 mRNA CTD PMID:19162046 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta increases expression EXP Oxidopamine results in increased expression of P4HB mRNA CTD PMID:12486162 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions
increases expression
decreases response to substance
affects localization		 ISO
EXP		 Oxidopamine promotes the reaction [Quinones binds to PARK7 protein]
Oxidopamine results in increased expression of PARK7 mRNA
[4-phenylbutyric acid results in increased expression of PARK7 protein] which results in decreased susceptibility to Oxidopamine; isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]; Levodopa inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]; Rutin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]
PARK7 protein results in decreased susceptibility to Oxidopamine
Oxidopamine results in increased expression of PARK7 mRNA; Oxidopamine results in increased expression of PARK7 protein
Oxidopamine affects the localization of PARK7 protein		 CTD PMID:18377993 PMID:20851755 PMID:21372141 PMID:25129099 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression
increases cleavage
increases activity		 ISO
EXP		 OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; pyrazolanthrone inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; TH protein inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; tricetin inhibits the reaction [Oxidopamine results in increased expression of PARP1 protein]
2-chloro-5-hydroxyphenylglycine affects the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; 6-methyl-2-(phenylethynyl)pyridine promotes the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; GOPC protein affects the reaction [2-chloro-5-hydroxyphenylglycine affects the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; GOPC protein affects the reaction [6-methyl-2-(phenylethynyl)pyridine promotes the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; GOPC protein affects the reaction [Oxidopamine results in increased cleavage of PARP1 protein]
Oxidopamine results in increased activity of PARP1 protein
5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Oxidopamine results in increased activity of PARP1 protein]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]		 CTD PMID:10397638 PMID:19815691 PMID:21397656 PMID:25446857 PMID:30707903 More... NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdcd10 programmed cell death 10 multiple interactions EXP
ISO		 PDCD10 protein affects the reaction [MIR107 mRNA affects the reaction [Oxidopamine affects the expression of HES1 protein]]; PDCD10 protein affects the reaction [MIR107 mRNA affects the reaction [Oxidopamine affects the expression of NOTCH1 protein]]
[Oxidopamine affects the reaction [MIR107 mRNA binds to PDCD10 3' UTR]] which affects the expression of PDCD10 mRNA; [Oxidopamine affects the reaction [MIR107 mRNA binds to PDCD10 3' UTR]] which affects the expression of PDCD10 protein; Oxidopamine affects the reaction [MIR107 mRNA binds to PDCD10 3' UTR]; PDCD10 protein affects the reaction [MIR107 mRNA affects the reaction [Oxidopamine affects the expression of HES1 protein]]; PDCD10 protein affects the reaction [MIR107 mRNA affects the reaction [Oxidopamine affects the expression of NOTCH1 protein]]		 CTD PMID:31778666 NCBI chr 2:160,303,465...160,346,086
Ensembl chr 2:160,303,449...160,346,018 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression EXP Oxidopamine results in decreased expression of PDGFRB mRNA CTD PMID:15518916 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta decreases expression ISO Oxidopamine results in decreased expression of PDHB mRNA CTD PMID:19763263 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression EXP Oxidopamine results in increased expression of PDIA3 mRNA CTD PMID:12486162 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 increases expression EXP Oxidopamine results in increased expression of PDIA6 mRNA CTD PMID:12486162 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Pdyn prodynorphin multiple interactions
increases expression
decreases expression		 ISO
EXP		 [Levodopa co-treated with Oxidopamine] results in increased expression of PDYN mRNA; [Levodopa co-treated with Oxidopamine] results in increased expression of PDYN protein; Levodopa inhibits the reaction [Oxidopamine results in decreased expression of PDYN mRNA]
Oxidopamine results in increased expression of PDYN mRNA
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]; [Levodopa co-treated with Oxidopamine] results in increased expression of PDYN mRNA; [Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA; [Oxidopamine co-treated with Levodopa] results in increased expression of PDYN protein; [TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]; Corticosterone inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]; IEM 1460 inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]; Levodopa inhibits the reaction [Oxidopamine results in decreased expression of PDYN mRNA]		 CTD PMID:7477882 PMID:12127155 PMID:14697317 PMID:15207268 PMID:15610165 More... NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin multiple interactions
increases expression		 ISO
EXP		 [Oxidopamine co-treated with Levodopa] results in increased expression of PENK mRNA
Oxidopamine results in increased expression of PENK mRNA; Oxidopamine results in increased expression of PENK protein
[Levodopa co-treated with Oxidopamine] results in increased expression of PENK mRNA; [Oxidopamine co-treated with Levodopa] results in increased expression of PENK mRNA; [TH co-treated with GCH1] inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of PENK mRNA]]; Corticosterone inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PENK mRNA]; IEM 1460 inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of PENK mRNA]]; Isradipine inhibits the reaction [Oxidopamine results in increased expression of PENK mRNA]; Levodopa promotes the reaction [Oxidopamine results in increased expression of PENK mRNA]; S 33084 inhibits the reaction [[Levodopa co-treated with Oxidopamine] results in increased expression of PENK mRNA]		 CTD PMID:3838946 PMID:12127155 PMID:15065221 PMID:15659429 PMID:16139809 More... NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pink1 PTEN induced kinase 1 decreases expression
multiple interactions		 ISO Oxidopamine results in decreased expression of PINK1 protein
PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of VDAC1 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of PINK1 protein]		 CTD PMID:30707903 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Pnoc prepronociceptin increases expression
decreases expression		 EXP Oxidopamine results in increased expression of PNOC mRNA
Oxidopamine results in decreased expression of PNOC mRNA		 CTD PMID:19162046 NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867 		JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases expression		 EXP Levodopa promotes the reaction [Oxidopamine results in increased expression of POMC protein] CTD PMID:16325000 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions		 ISO Oxidopamine results in decreased expression of PPARGC1A protein
LY 344864 inhibits the reaction [Oxidopamine results in decreased expression of PPARGC1A protein]		 CTD PMID:29057453 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppib peptidylprolyl isomerase B increases expression EXP Oxidopamine results in increased expression of PPIB mRNA CTD PMID:12486162 NCBI chr 8:66,603,877...66,609,734
Ensembl chr 8:66,603,861...66,630,428 		JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions
increases expression		 EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PPID mRNA]; Levodopa inhibits the reaction [Oxidopamine results in increased expression of PPID mRNA]; Rutin inhibits the reaction [Oxidopamine results in increased expression of PPID mRNA] CTD PMID:25129099 NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO
EXP		 [benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of PPP1R1B protein
[Oxidopamine co-treated with Levodopa] affects the phosphorylation of PPP1R1B protein		 CTD PMID:17188499 PMID:17596448 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions
decreases phosphorylation		 EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]; Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]; Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein] CTD PMID:16339297 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions
increases response to substance		 ISO
EXP		 Oxidopamine results in increased cleavage of and results in increased activity of PRKCD protein
PRKCD protein results in increased susceptibility to Oxidopamine
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Oxidopamine results in increased cleavage of and results in increased activity of PRKCD protein]; Oxidopamine results in increased cleavage of and results in increased activity of PRKCD protein		 CTD PMID:21846476 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases reaction
affects expression
decreases expression
multiple interactions
increases expression		 ISO
EXP		 PRKN protein inhibits the reaction Oxidopamine
Oxidopamine affects the expression of PRKN protein alternative form
Oxidopamine results in decreased expression of PRKN protein
PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]; Tretinoin affects the reaction [Oxidopamine affects the expression of PRKN protein alternative form]
PRKN protein inhibits the reaction [Oxidopamine results in decreased expression of TH protein]
Oxidopamine results in increased expression of PRKN mRNA
isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA]; Levodopa inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA]; Rutin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA]		 CTD PMID:15198987 PMID:16914382 PMID:25129099 PMID:28688199 PMID:30707903 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Prss1 serine protease 1 multiple interactions
decreases activity		 EXP Resveratrol inhibits the reaction [Oxidopamine results in decreased activity of PRSS1 protein] CTD PMID:34302886 NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:70,364,586...70,367,792 		JBrowse link
G Psma2 proteasome 20S subunit alpha 2 increases expression EXP Oxidopamine results in increased expression of PSMA2 mRNA CTD PMID:12486162 NCBI chr17:50,554,536...50,564,923
Ensembl chr17:50,551,924...50,564,938 		JBrowse link
G Psmb2 proteasome 20S subunit beta 2 increases expression EXP Oxidopamine results in increased expression of PSMB2 mRNA CTD PMID:12486162 NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137 		JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 increases expression EXP Oxidopamine results in increased expression of PSMC4 mRNA CTD PMID:12486162 NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494 		JBrowse link
G Ptger4 prostaglandin E receptor 4 increases expression ISO Oxidopamine results in increased expression of PTGER4 mRNA CTD PMID:31247335 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptgfr prostaglandin F receptor increases expression
multiple interactions		 ISO Oxidopamine results in increased expression of PTGFR protein
PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]]		 CTD PMID:33486071 NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO
EXP		 N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Oxidopamine results in increased expression of PTGS2 protein]
rosiglitazone inhibits the reaction [Oxidopamine results in increased expression of PTGS2 protein]
Oxidopamine results in increased expression of PTGS2 mRNA; Oxidopamine results in increased expression of PTGS2 protein		 CTD PMID:17855475 PMID:20851755 PMID:22842585 PMID:31247335 PMID:33486071 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 multiple interactions EXP [Levodopa co-treated with Oxidopamine] affects the expression of RASGRP1 mRNA; [Levodopa co-treated with Oxidopamine] affects the expression of RASGRP1 protein CTD PMID:19171906 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
increases phosphorylation
increases activity		 EXP
ISO		 Oxidopamine results in increased localization of and results in increased activity of RELA protein; SN50 peptide inhibits the reaction [Oxidopamine results in increased localization of RELA protein]
N-(1-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide inhibits the reaction [Oxidopamine affects the localization of RELA protein]
chrysin inhibits the reaction [Oxidopamine results in increased phosphorylation of RELA protein]
Oxidopamine results in increased activity of RELA protein		 CTD PMID:17368433 PMID:20851755 PMID:29054324 PMID:31247335 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ret ret proto-oncogene decreases response to substance ISO RET protein mutant form results in decreased susceptibility to Oxidopamine CTD PMID:19767128 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 multiple interactions ISO [benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of RPS6KA5 protein; [Oxidopamine co-treated with Levodopa] results in increased expression of RPS6KA5 protein; SCH 23390 inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of RPS6KA5 protein]; SL 327 inhibits the reaction [[benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of RPS6KA5 protein] CTD PMID:17596448 PMID:19187092 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224 		JBrowse link
G S100b S100 calcium binding protein B multiple interactions
increases expression		 ISO chrysin inhibits the reaction [Oxidopamine results in increased expression of S100B protein] CTD PMID:29054324 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Sec11c SEC11 homolog C, signal peptidase complex subunit increases expression EXP Oxidopamine results in increased expression of SEC11C mRNA CTD PMID:12486162 NCBI chr18:59,320,932...59,337,272
Ensembl chr18:59,320,884...59,337,364 		JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 increases expression EXP Oxidopamine results in increased expression of SERP1 mRNA CTD PMID:12486162 NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116 		JBrowse link
G Sh3kbp1 SH3 domain-containing kinase-binding protein 1 increases expression ISO Oxidopamine results in increased expression of SH3KBP1 mRNA CTD PMID:18535749 NCBI chr  X:34,877,862...35,223,013
Ensembl chr  X:34,877,866...35,222,747 		JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions EXP SHH protein modified form affects the susceptibility to [Apomorphine co-treated with Oxidopamine]; SHH protein modified form affects the susceptibility to [Dextroamphetamine co-treated with Oxidopamine] CTD PMID:11771942 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression		 ISO puag-haad inhibits the reaction [Oxidopamine results in decreased expression of SIRT1 protein] CTD PMID:18675900 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 decreases expression
multiple interactions		 ISO
EXP		 Oxidopamine results in decreased expression of SLC18A2 mRNA
Resveratrol inhibits the reaction [Oxidopamine results in decreased expression of SLC18A2 protein]		 CTD PMID:17803225 PMID:34302886 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP [Levodopa co-treated with Oxidopamine] results in increased expression of SLC1A2 mRNA CTD PMID:17329435 NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Slc1a3 solute carrier family 1 member 3 increases expression EXP Oxidopamine results in increased expression of SLC1A3 mRNA CTD PMID:15518916 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions
decreases expression		 ISO
EXP		 Oxidopamine promotes the reaction [ACO1 protein results in decreased expression of SLC40A1 mRNA]; Oxidopamine promotes the reaction [IREB2 protein results in decreased expression of SLC40A1 mRNA]
Oxidopamine results in decreased expression of SLC40A1 mRNA; Oxidopamine results in decreased expression of SLC40A1 protein		 CTD PMID:19913091 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases expression
multiple interactions
increases response to substance
increases expression		 EXP
ISO		 Oxidopamine results in decreased expression of SLC6A3 mRNA; Oxidopamine results in decreased expression of SLC6A3 protein
Resveratrol inhibits the reaction [Oxidopamine results in increased expression of SLC6A3 protein]
SLC6A3 protein results in increased susceptibility to Oxidopamine
Oxidopamine results in increased expression of SLC6A3 mRNA; Oxidopamine results in increased expression of SLC6A3 protein		 CTD PMID:10881039 PMID:15303306 PMID:15518916 PMID:20200117 PMID:34252731 More... NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions EXP [Oxidopamine co-treated with Levodopa] results in increased expression of SLC6A4 protein CTD PMID:20882603 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Snai3 snail family transcriptional repressor 3 increases expression ISO Oxidopamine results in increased expression of SNAI3 mRNA CTD PMID:32870474 NCBI chr19:50,516,771...50,529,295
Ensembl chr19:50,516,771...50,523,486 		JBrowse link
G Snca synuclein alpha increases expression
increases response to substance		 ISO
EXP		 Oxidopamine results in increased expression of SNCA mRNA alternative form
Oxidopamine results in increased expression of SNCA protein
SNCA protein mutant form results in increased susceptibility to Oxidopamine		 CTD PMID:16297908 PMID:19857570 PMID:22016808 PMID:31022188 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression		 ISO
EXP		 salvin inhibits the reaction [Oxidopamine results in decreased expression of SOD1 protein]
Oxidopamine results in decreased expression of SOD1 mRNA; Oxidopamine results in decreased expression of SOD1 protein		 CTD PMID:11730701 PMID:25446857 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 affects expression EXP Oxidopamine affects the expression of SOD2 mRNA CTD PMID:11730701 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP Oxidopamine results in decreased expression of SPP1 protein CTD PMID:24486959 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression		 ISO
EXP		 Oxidopamine promotes the reaction [SQSTM1 protein binds to and results in decreased activity of SQSTM1 protein]
Oxidopamine results in decreased expression of SQSTM1 protein		 CTD PMID:26409479 PMID:28802652 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Ssr2 signal sequence receptor subunit 2 increases expression EXP Oxidopamine results in increased expression of SSR2 mRNA CTD PMID:12486162 NCBI chr 2:174,048,291...174,057,043
Ensembl chr 2:174,048,460...174,057,042 		JBrowse link
G Ssr4 signal sequence receptor subunit 4 increases expression EXP Oxidopamine results in increased expression of SSR4 mRNA CTD PMID:12486162 NCBI chr  X:151,524,191...151,528,218
Ensembl chr  X:151,524,009...151,528,202 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 multiple interactions
increases expression		 EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of STUB1 mRNA]; Levodopa inhibits the reaction [Oxidopamine results in increased expression of STUB1 mRNA] CTD PMID:25129099 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
G Syp synaptophysin multiple interactions
decreases expression		 EXP Resveratrol inhibits the reaction [Oxidopamine results in decreased expression of SYP protein] CTD PMID:34302886 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression
increases expression		 EXP Oxidopamine results in decreased expression of TAC1 mRNA
Oxidopamine results in increased expression of TAC1 mRNA		 CTD PMID:15303306 PMID:15610165 PMID:18687386 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions
decreases expression		 ISO LY 344864 inhibits the reaction [Oxidopamine results in decreased expression of TFAM protein] CTD PMID:29057453 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Th tyrosine hydroxylase affects response to substance
multiple interactions
decreases expression		 ISO
EXP		 TH protein affects the susceptibility to Oxidopamine
2-chloro-5-hydroxyphenylglycine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein]; 3-methyladenine inhibits the reaction [Oxidopamine results in decreased expression of TH protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein]; [GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein; [TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein]; [TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]; [TH co-treated with GCH1] inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of PENK mRNA]]; Drugs, Chinese Herbal inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]]; isoquercitrin promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]; Levodopa inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]; Levodopa promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]; MDL 201053 inhibits the reaction [Oxidopamine results in decreased expression of TH protein]; Resveratrol inhibits the reaction [Oxidopamine results in decreased expression of TH protein]; Rosiglitazone inhibits the reaction [Oxidopamine results in decreased expression of TH protein]; Rutin inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]; salvin inhibits the reaction [Oxidopamine results in decreased expression of TH protein]; Tea inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]; Tea inhibits the reaction [Oxidopamine results in decreased expression of TH protein]
Oxidopamine results in decreased expression of TH mRNA; Oxidopamine results in decreased expression of TH protein
LY 344864 inhibits the reaction [Oxidopamine results in decreased expression of TH protein]; PRKN protein inhibits the reaction [Oxidopamine results in decreased expression of TH protein]; sulforaphane inhibits the reaction [Oxidopamine results in decreased expression of TH protein]
TH protein inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]		 CTD PMID:9460767 PMID:11730701 PMID:12585172 PMID:14696016 PMID:15659429 More... NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression
decreases response to substance		 ISO Oxidopamine results in decreased expression of TIMP2 mRNA; Oxidopamine results in decreased expression of TIMP2 protein
TIMP2 protein results in decreased susceptibility to Oxidopamine		 CTD PMID:19883732 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP
ISO		 Oxidopamine results in increased expression of TNF protein
chrysin inhibits the reaction [Oxidopamine results in increased expression of TNF protein]
Resveratrol inhibits the reaction [Oxidopamine results in increased expression of TNF protein]; Rosiglitazone inhibits the reaction [Oxidopamine results in increased expression of TNF protein]		 CTD PMID:22842585 PMID:29054324 PMID:34302886 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B decreases response to substance ISO TNFRSF1B protein results in decreased susceptibility to Oxidopamine CTD PMID:22110694 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Tor1a torsin family 1, member A decreases expression EXP Oxidopamine results in decreased expression of TOR1A protein CTD PMID:16325337 NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 EXP SN50 peptide inhibits the reaction [Oxidopamine results in increased expression of TP53 protein] CTD PMID:17368433 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP [Levodopa co-treated with Oxidopamine] results in increased expression of TRH mRNA; [Levodopa co-treated with Oxidopamine] results in increased expression of TRH protein CTD PMID:21085660 NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions
increases expression		 ISO fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]] CTD PMID:33486071 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ubc ubiquitin C increases expression EXP Oxidopamine results in increased expression of UBC mRNA CTD PMID:12486162 NCBI chr12:31,238,889...31,243,924
Ensembl chr12:31,239,152...31,243,925 		JBrowse link
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 increases expression EXP Oxidopamine results in increased expression of UBE2D3 mRNA CTD PMID:12486162 NCBI chr 2:223,868,397...223,899,606
Ensembl chr 2:223,868,730...223,898,081 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions
increases expression		 EXP isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA]; Levodopa inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA]; Rutin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA] CTD PMID:25129099 NCBI chr14:41,485,033...41,495,590
Ensembl chr14:41,485,031...41,495,590 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO Oxidopamine results in decreased expression of and results in decreased ubiquitination of VDAC1 protein; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of VDAC1 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of and results in decreased ubiquitination of VDAC1 protein] CTD PMID:30707903 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        aetiopathogenetic role 19148
          neurotoxin 18047
            oxidopamine 196
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    main group molecular entity 19761
                      s-block molecular entity 19612
                        hydrogen molecular entity 19601
                          hydrides 19077
                            inorganic hydride 17986
                              pnictogen hydride 17973
                                nitrogen hydride 17870
                                  azane 17655
                                    ammonia 17654
                                      organic amino compound 17654
                                        aralkylamino compound 981
                                          monoamine 603
                                            monoamine molecular messenger 603
                                              catecholamine 550
                                                dopamine 374
                                                  oxidopamine 196
paths to the root