Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cantharidic acid
go back to main search page
Accession:CHEBI:78695 term browser browse the term
Definition:A monoterpenoid with an epoxy-bridged bicyclic dicarboxylic acid structure, which acts as an inhibitor of protein phosphatases 1 and 2A.
Synonyms:exact_synonym: (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
 related_synonym: Formula=C10H14O5;   InChI=1S/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6+,9+,10-;   InChIKey=NMTNUQBORQILRK-XCVPVQRUSA-N;   SMILES=C[C@@]1([C@@H]2CC[C@@H](O2)[C@@]1(C)C(O)=O)C(O)=O
 xref: CAS:28874-45-5
 xref_mesh: MESH:C000626960
 xref: PMID:10403630;   PMID:10900240;   PMID:22210093;   PMID:22337773;   PMID:2955551;   Patent:WO2011056222;   Reaxys:17311;   Wikipedia:Cantharidic_acid

show annotations for term's descendants           Sort by:
 
cantharidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO SB 203580 inhibits the reaction [cantharidic acid results in increased cleavage of CASP3 protein] CTD PMID:29159945, PMID:29345422, PMID:31916385 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions		 ISO cantharidic acid results in increased cleavage of CASP8 protein
SB 203580 inhibits the reaction [cantharidic acid results in increased cleavage of CASP8 protein]		 CTD PMID:29159945, PMID:29345422, PMID:31916385 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO cantharidic acid results in increased cleavage of CASP9 protein
SB 203580 inhibits the reaction [cantharidic acid results in increased cleavage of CASP9 protein]		 CTD PMID:29159945, PMID:29345422, PMID:31916385 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO U 0126 inhibits the reaction [cantharidic acid results in increased phosphorylation of MAPK1 protein]
cantharidic acid results in decreased phosphorylation of MAPK1 protein		 CTD PMID:29159945, PMID:29345422, PMID:31916385 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO U 0126 inhibits the reaction [cantharidic acid results in increased phosphorylation of MAPK3 protein]
cantharidic acid results in decreased phosphorylation of MAPK3 protein		 CTD PMID:29159945, PMID:29345422, PMID:31916385 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO cantharidic acid results in increased phosphorylation of MAPK8 protein CTD PMID:29345422, PMID:31916385 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO cantharidic acid results in increased phosphorylation of MAPK9 protein CTD PMID:29345422 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO cantharidic acid results in increased cleavage of PARP1 protein CTD PMID:29159945, PMID:29345422, PMID:31916385 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          hepatotoxic agent 14588
            cantharidic acid 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic anhydride 1955
                                        cyclic dicarboxylic anhydride 1951
                                          cantharidin 43
                                            cantharidic acid 8
paths to the root

Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.