Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cantharidic acid
go back to main search page
Accession:CHEBI:78695 term browser browse the term
Definition:A monoterpenoid with an epoxy-bridged bicyclic dicarboxylic acid structure, which acts as an inhibitor of protein phosphatases 1 and 2A.
Synonyms:exact_synonym: (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
 related_synonym: Formula=C10H14O5;   InChI=1S/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6+,9+,10-;   InChIKey=NMTNUQBORQILRK-XCVPVQRUSA-N;   SMILES=C[C@@]1([C@@H]2CC[C@@H](O2)[C@@]1(C)C(O)=O)C(O)=O
 xref: CAS:28874-45-5
 xref_mesh: MESH:C000626960
 xref: PMID:10403630;   PMID:10900240;   PMID:22210093;   PMID:22337773;   PMID:2955551;   Patent:WO2011056222;   Reaxys:17311;   Wikipedia:Cantharidic_acid


show annotations for term's descendants           Sort by:
 
cantharidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO SB 203580 inhibits the reaction [cantharidic acid results in increased cleavage of CASP3 protein] CTD PMID:29159945, PMID:29345422, PMID:31916385 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
ISO cantharidic acid results in increased cleavage of CASP8 protein
SB 203580 inhibits the reaction [cantharidic acid results in increased cleavage of CASP8 protein]
CTD PMID:29159945, PMID:29345422, PMID:31916385 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO cantharidic acid results in increased cleavage of CASP9 protein
SB 203580 inhibits the reaction [cantharidic acid results in increased cleavage of CASP9 protein]
CTD PMID:29159945, PMID:29345422, PMID:31916385 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO U 0126 inhibits the reaction [cantharidic acid results in increased phosphorylation of MAPK1 protein]
cantharidic acid results in decreased phosphorylation of MAPK1 protein
CTD PMID:29159945, PMID:29345422, PMID:31916385 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO U 0126 inhibits the reaction [cantharidic acid results in increased phosphorylation of MAPK3 protein]
cantharidic acid results in decreased phosphorylation of MAPK3 protein
CTD PMID:29159945, PMID:29345422, PMID:31916385 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO cantharidic acid results in increased phosphorylation of MAPK8 protein CTD PMID:29345422, PMID:31916385 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO cantharidic acid results in increased phosphorylation of MAPK9 protein CTD PMID:29345422 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO cantharidic acid results in increased cleavage of PARP1 protein CTD PMID:29159945, PMID:29345422, PMID:31916385 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          hepatotoxic agent 14588
            cantharidic acid 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic anhydride 1955
                                        cyclic dicarboxylic anhydride 1951
                                          cantharidin 43
                                            cantharidic acid 8
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.