Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cantharidic acid
go back to main search page
Accession:CHEBI:78695 term browser browse the term
Definition:A monoterpenoid with an epoxy-bridged bicyclic dicarboxylic acid structure, which acts as an inhibitor of protein phosphatases 1 and 2A.
Synonyms:exact_synonym: (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
 related_synonym: Formula=C10H14O5;   InChI=1S/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6+,9+,10-;   InChIKey=NMTNUQBORQILRK-XCVPVQRUSA-N;   SMILES=C[C@@]1([C@@H]2CC[C@@H](O2)[C@@]1(C)C(O)=O)C(O)=O
 xref: CAS:28874-45-5
 xref_mesh: MESH:C000626960
 xref: PMID:10403630;   PMID:10900240;   PMID:22210093;   PMID:22337773;   PMID:2955551;   Patent:WO2011056222;   Reaxys:17311;   Wikipedia:Cantharidic_acid


show annotations for term's descendants           Sort by:
 
cantharidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO SB 203580 inhibits the reaction [cantharidic acid results in increased cleavage of CASP3 protein] CTD PMID:29159945 PMID:29345422 PMID:31916385 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions		 ISO cantharidic acid results in increased cleavage of CASP8 protein
SB 203580 inhibits the reaction [cantharidic acid results in increased cleavage of CASP8 protein]		 CTD PMID:29159945 PMID:29345422 PMID:31916385 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO cantharidic acid results in increased cleavage of CASP9 protein
SB 203580 inhibits the reaction [cantharidic acid results in increased cleavage of CASP9 protein]		 CTD PMID:29159945 PMID:29345422 PMID:31916385 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO U 0126 inhibits the reaction [cantharidic acid results in increased phosphorylation of MAPK1 protein]
cantharidic acid results in decreased phosphorylation of MAPK1 protein		 CTD PMID:29159945 PMID:29345422 PMID:31916385 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO U 0126 inhibits the reaction [cantharidic acid results in increased phosphorylation of MAPK3 protein]
cantharidic acid results in decreased phosphorylation of MAPK3 protein		 CTD PMID:29159945 PMID:29345422 PMID:31916385 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO cantharidic acid results in increased phosphorylation of MAPK8 protein CTD PMID:29345422 PMID:31916385 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO cantharidic acid results in increased phosphorylation of MAPK9 protein CTD PMID:29345422 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO cantharidic acid results in increased cleavage of PARP1 protein CTD PMID:29159945 PMID:29345422 PMID:31916385 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20083
    role 20034
      biological role 20033
        aetiopathogenetic role 19297
          hepatotoxic agent 16251
            cantharidic acid 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20083
    subatomic particle 20081
      composite particle 20081
        hadron 20081
          baryon 20081
            nucleon 20081
              atomic nucleus 20081
                atom 20081
                  main group element atom 19982
                    p-block element atom 19982
                      carbon group element atom 19909
                        carbon atom 19902
                          organic molecular entity 19902
                            organic group 18982
                              organic divalent group 18968
                                organodiyl group 18968
                                  carbonyl group 18919
                                    carbonyl compound 18919
                                      carboxylic anhydride 1962
                                        cyclic dicarboxylic anhydride 1958
                                          cantharidin 49
                                            cantharidic acid 8
paths to the root