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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 4.6.1.2 (guanylate cyclase) inhibitor
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Accession:CHEBI:78678 term browser browse the term
Definition:An EC 4.6.* (P-O lyase) inhibitor that interferes with the action of enzyme guanylate cyclase (EC 4.6.1.2).
Synonyms:related_synonym: EC 4.6.1.2 (guanylate cyclase) inhibitors;   EC 4.6.1.2 inhibitor;   EC 4.6.1.2 inhibitors;   GTP diphosphate-lyase (cyclizing) inhibitor;   GTP diphosphate-lyase (cyclizing) inhibitors;   GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) inhibitor;   GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) inhibitors;   guanyl cyclase inhibitor;   guanyl cyclase inhibitors;   guanylyl cyclase inhibitor;   guanylyl cyclase inhibitors
 xref: Wikipedia:Guanylate_cyclase


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1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] CTD PMID:14662737 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294 		JBrowse link
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions
increases degradation		 EXP BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein] CTD PMID:19466990 NCBI chr 8:44,448,758...44,520,737
Ensembl chr 8:44,449,290...44,518,135 		JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 increases degradation
multiple interactions		 EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein
BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein]		 CTD PMID:19466990 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,687 		JBrowse link
6-anilino-5,8-quinolinedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOD1 superoxide dismutase 1 multiple interactions EXP SOD1 protein affects the susceptibility to [Ditiocarb co-treated with 6-anilino-5,8-quinolinedione] CTD PMID:11861319 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 5177
    role 5144
      biological role 5144
        biochemical role 5066
          enzyme inhibitor 524
            EC 4.* (lyase) inhibitor 66
              EC 4.6.* (P-O lyase) inhibitor 4
                EC 4.6.1.2 (guanylate cyclase) inhibitor 4
                  1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one 3
                  6-anilino-5,8-quinolinedione 1
                  methylene blue 0
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