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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 4.6.1.2 (guanylate cyclase) inhibitor
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Accession:CHEBI:78678 term browser browse the term
Definition:An EC 4.6.* (P-O lyase) inhibitor that interferes with the action of enzyme guanylate cyclase (EC 4.6.1.2).
Synonyms:related_synonym: EC 4.6.1.2 (guanylate cyclase) inhibitors;   EC 4.6.1.2 inhibitor;   EC 4.6.1.2 inhibitors;   GTP diphosphate-lyase (cyclizing) inhibitor;   GTP diphosphate-lyase (cyclizing) inhibitors;   GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) inhibitor;   GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) inhibitors;   guanyl cyclase inhibitor;   guanyl cyclase inhibitors;   guanylyl cyclase inhibitor;   guanylyl cyclase inhibitors
 xref: Wikipedia:Guanylate_cyclase



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1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adnp activity-dependent neuroprotective protein decreases expression ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of ADNP mRNA; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of ADNP protein CTD PMID:18375135 NCBI chr 2:168,022,885...168,049,032
Ensembl chr 2:168,022,906...168,049,032
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Bax BCL2-associated X protein increases expression ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased expression of BAX protein CTD PMID:16288207 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bglap bone gamma carboxyglutamate protein decreases expression ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of BGLAP mRNA CTD PMID:22543296 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in decreased expression of BNIP3 mRNA] CTD PMID:11592958 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased activity of CASP3 protein
1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [Nitric Oxide Donors results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]]
CTD PMID:9388267 PMID:16288207 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased expression of CDKN1A protein CTD PMID:16288207 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Col1a2 collagen, type I, alpha 2 multiple interactions
decreases expression
ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [NOC 18 results in increased expression of COL1A2 mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of COL1A2 mRNA
CTD PMID:22543296 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4I1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of COX4I1 protein]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of COX4I1 protein] CTD PMID:24041027 NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Dusp10 dual specificity phosphatase 10 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 protein] CTD PMID:29165873 NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in decreased expression of ENPP1 protein] CTD PMID:21414308 NCBI chr10:24,513,812...24,588,057
Ensembl chr10:24,513,812...24,588,057
JBrowse link
G Gabpa GA repeat binding protein, alpha multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein] CTD PMID:17179207 NCBI chr16:84,631,795...84,660,671
Ensembl chr16:84,631,813...84,660,667
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:17110411 NCBI chr14:67,982,717...67,986,889
Ensembl chr14:67,982,630...67,986,888
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased activity of GSK3B protein] CTD PMID:19135050 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Gucy1a1 guanylate cyclase 1, soluble, alpha 1 multiple interactions
increases degradation
ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [1,1-diethyl-2-hydroxy-2-nitrosohydrazine results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [dicyanocobinamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; [BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [3-(2-(2,2-dimethylpropylsulfanyl)pyridin-3-yl)-N-(3-hydroxycyclohexyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [3-(2-(4-chlorophenylsulfanyl)phenyl)-N-(4-dimethylaminobutyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein]
CTD PMID:11744065 PMID:12495780 PMID:17050951 PMID:19466990 PMID:22171090 NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096
JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 multiple interactions
increases degradation
ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [1,1-diethyl-2-hydroxy-2-nitrosohydrazine results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [dicyanocobinamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; [BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [3-(2-(2,2-dimethylpropylsulfanyl)pyridin-3-yl)-N-(3-hydroxycyclohexyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [3-(2-(4-chlorophenylsulfanyl)phenyl)-N-(4-dimethylaminobutyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein
CTD PMID:11744065 PMID:12495780 PMID:17050951 PMID:19466990 PMID:22171090 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of HMOX1 protein] CTD PMID:24041027 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Ibsp integrin binding sialoprotein multiple interactions
decreases expression
ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased expression of IBSP mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [NOC 18 results in increased expression of IBSP mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of IBSP mRNA
CTD PMID:22543296 NCBI chr 5:104,447,153...104,459,338
Ensembl chr 5:104,447,037...104,459,335
JBrowse link
G Il12rb2 interleukin 12 receptor, beta 2 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [NOC 18 results in increased expression of IL12RB2 mRNA] CTD PMID:12451176 NCBI chr 6:67,263,914...67,353,277
Ensembl chr 6:67,268,302...67,353,172
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases expression ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased expression of MDM2 protein CTD PMID:16288207 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of NDUFB8 protein] CTD PMID:24041027 NCBI chr19:44,537,010...44,543,881
Ensembl chr19:44,537,011...44,543,879
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of NRF1 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of NRF1 mRNA]
CTD PMID:17179207 PMID:24041027 NCBI chr 6:30,047,984...30,153,462
Ensembl chr 6:30,047,987...30,153,457
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of PPARGC1A mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of PPARGC1A mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]
CTD PMID:17179207 PMID:24041027 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Prkg1 protein kinase, cGMP-dependent, type I multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein] CTD PMID:15617736 NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO ODQ inhibits the reaction [SNAP increases activity of Ptpn1 protein in aortic smooth muscle cells] RGD PMID:10484424 RGD:401965470 NCBI chr 2:167,772,670...167,821,305
Ensembl chr 2:167,773,977...167,821,305
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA] CTD PMID:14996425 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
decreases expression
ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased expression of SPP1 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [NOC 18 results in increased expression of SPP1 mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of SPP1 mRNA
CTD PMID:22543296 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of TFAM mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of TFAM mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]
CTD PMID:17179207 PMID:24041027 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased stability of and results in increased expression of and results in increased phosphorylation of TP53 protein CTD PMID:16288207 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of UQCRC1 protein] CTD PMID:24041027 NCBI chr 9:108,765,716...108,778,709
Ensembl chr 9:108,765,701...108,778,691
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased phosphorylation of VASP protein] CTD PMID:17868048 NCBI chr 7:18,990,854...19,005,779
Ensembl chr 7:18,990,854...19,005,742
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases activity ISO XIAP protein results in decreased activity of 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one CTD PMID:16288207 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533
JBrowse link
6-anilino-5,8-quinolinedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO 6-anilino-5,8-quinolinedione inhibits the reaction [sodium bichromate results in increased ubiquitination of BCL2 protein]
6-anilino-5,8-quinolinedione results in decreased expression of BCL2 protein
CTD PMID:18544562 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bdnf brain derived neurotrophic factor decreases response to substance ISO BDNF protein results in decreased susceptibility to 6-anilino-5,8-quinolinedione CTD PMID:22261313 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 multiple interactions ISO 6-anilino-5,8-quinolinedione results in increased expression of and results in increased secretion of HSP90AA1 protein CTD PMID:10617604 NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 increases expression ISO 6-anilino-5,8-quinolinedione results in increased expression of HSP90AB1 protein CTD PMID:10617604 NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197
JBrowse link
G Il4 interleukin 4 decreases secretion EXP 6-anilino-5,8-quinolinedione results in decreased secretion of IL4 protein CTD PMID:16533816 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Il5 interleukin 5 decreases secretion EXP 6-anilino-5,8-quinolinedione results in decreased secretion of IL5 protein CTD PMID:16533816 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 6-anilino-5,8-quinolinedione inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:35122928 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 6-anilino-5,8-quinolinedione inhibits the reaction [heat stable toxin (E coli) results in decreased expression of VEGFA protein] CTD PMID:17828804 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
methylene blue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Methylene Blue results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide multiple interactions EXP Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of ATP1A2 protein] CTD PMID:31173149 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein] CTD PMID:31428839 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein] CTD PMID:31428839 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit multiple interactions EXP Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of CACNA1C protein] CTD PMID:31173149 NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions ISO Methylene Blue inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA] CTD PMID:11919648 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases activity ISO Methylene Blue results in increased activity of G6PD protein CTD PMID:1901343 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA] CTD PMID:24556215 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA CTD PMID:24556215 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein] CTD PMID:24556215 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Glrx glutaredoxin multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA CTD PMID:24556215 NCBI chr13:75,988,004...75,998,270
Ensembl chr13:75,987,987...75,998,273
JBrowse link
G Glrx2 glutaredoxin 2 multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA CTD PMID:24556215 NCBI chr 1:143,614,787...143,625,416
Ensembl chr 1:143,592,076...143,625,414
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions ISO Methylene Blue inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:17290048 NCBI chr14:67,982,717...67,986,889
Ensembl chr14:67,982,630...67,986,888
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Methylene Blue inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP
ISO
[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]
Methylene Blue results in increased expression of HMOX1 protein
CTD PMID:24556215 PMID:25943564 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein] CTD PMID:31428839 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein] CTD PMID:31428839 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] CTD PMID:31428839 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO Methylene Blue inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr10:3,490,274...3,504,880
Ensembl chr10:3,490,240...3,504,877
JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases activity
ISO Methylene Blue inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]
Methylene Blue results in decreased activity of MAOB protein
CTD PMID:21554916 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605
JBrowse link
G Mapt microtubule-associated protein tau decreases expression
multiple interactions
decreases phosphorylation
increases expression
ISO
EXP
Methylene Blue results in decreased expression of MAPT protein
[Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA; Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA]; Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA]; Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein]
Methylene Blue results in decreased phosphorylation of MAPT protein modified form
Methylene Blue results in increased expression of MAPT mRNA
CTD PMID:16930453 PMID:24556215 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Methylene Blue inhibits the reaction [Paraquat results in increased expression of MPO protein]; Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein] CTD PMID:25943564 PMID:31428839 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions EXP
ISO
[Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA]
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA]
CTD PMID:24556215 PMID:31428839 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]
CTD PMID:24556215 PMID:31428839 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases expression
EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA] CTD PMID:24556215 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Pgd phosphogluconate dehydrogenase increases activity ISO Methylene Blue results in increased activity of PGD protein CTD PMID:1901343 NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA CTD PMID:24556215 NCBI chr 1:161,067,682...161,078,780
Ensembl chr 1:161,067,682...161,078,789
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP Methylene Blue inhibits the reaction [Sodium Cyanide results in increased activity of and affects the localization of PRKCE protein] CTD PMID:31173149 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347
JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 multiple interactions
increases activity
EXP oxophenylarsine inhibits the reaction [Methylene Blue results in increased activity of SLC2A1 protein] CTD PMID:19686715 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Methylene Blue inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein] CTD PMID:11744139 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trp53 transformation related protein 53 affects activity ISO Methylene Blue affects the activity of TP53 protein CTD PMID:35435491 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA] CTD PMID:24556215 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Txn2 thioredoxin 2 multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA CTD PMID:24556215 NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions EXP Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA] CTD PMID:24556215 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
G Txnrd2 thioredoxin reductase 2 multiple interactions EXP [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA CTD PMID:24556215 NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 22222
    role 22205
      biological role 22204
        biochemical role 21499
          enzyme inhibitor 19920
            EC 4.* (lyase) inhibitor 7388
              EC 4.6.* (P-O lyase) inhibitor 75
                EC 4.6.1.2 (guanylate cyclase) inhibitor 70
                  1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one 33
                  6-anilino-5,8-quinolinedione 8
                  methylene blue 35
paths to the root