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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 4.6.1.2 (guanylate cyclase) inhibitor
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Accession:CHEBI:78678 term browser browse the term
Definition:An EC 4.6.* (P-O lyase) inhibitor that interferes with the action of enzyme guanylate cyclase (EC 4.6.1.2).
Synonyms:related_synonym: EC 4.6.1.2 (guanylate cyclase) inhibitors;   EC 4.6.1.2 inhibitor;   EC 4.6.1.2 inhibitors;   GTP diphosphate-lyase (cyclizing) inhibitor;   GTP diphosphate-lyase (cyclizing) inhibitors;   GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) inhibitor;   GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) inhibitors;   guanyl cyclase inhibitor;   guanyl cyclase inhibitors;   guanylyl cyclase inhibitor;   guanylyl cyclase inhibitors
 xref: Wikipedia:Guanylate_cyclase



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1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADNP activity dependent neuroprotector homeobox decreases expression ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of ADNP mRNA; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of ADNP protein CTD PMID:18375135 NCBI chr20:50,888,918...50,931,437
Ensembl chr20:50,888,916...50,931,437
JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased expression of BAX protein CTD PMID:16288207 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein decreases expression EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of BGLAP mRNA CTD PMID:22543296 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G BNIP3 BCL2 interacting protein 3 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in decreased expression of BNIP3 mRNA] CTD PMID:11592958 NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967
JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions
EXP
ISO
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased activity of CASP3 protein
1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [Nitric Oxide Donors results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]]
CTD PMID:9388267 PMID:16288207 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased expression of CDKN1A protein CTD PMID:16288207 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G COL1A2 collagen type I alpha 2 chain multiple interactions
decreases expression
EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [NOC 18 results in increased expression of COL1A2 mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of COL1A2 mRNA
CTD PMID:22543296 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
JBrowse link
G COX4I1 cytochrome c oxidase subunit 4I1 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of COX4I1 protein]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of COX4I1 protein] CTD PMID:24041027 NCBI chr16:85,799,695...85,807,068
Ensembl chr16:85,798,633...85,807,068
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G DUSP10 dual specificity phosphatase 10 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [andrographolide results in increased expression of DUSP10 protein] CTD PMID:29165873 NCBI chr 1:221,701,424...221,742,089
Ensembl chr 1:221,701,424...221,742,089
JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in decreased expression of ENPP1 protein] CTD PMID:21414308 NCBI chr 6:131,808,020...131,895,155
Ensembl chr 6:131,808,016...131,895,155
JBrowse link
G GABPA GA binding protein transcription factor subunit alpha multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein] CTD PMID:17179207 NCBI chr21:25,734,972...25,772,460
Ensembl chr21:25,734,570...25,772,460
JBrowse link
G GNRH1 gonadotropin releasing hormone 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:17110411 NCBI chr 8:25,419,258...25,425,040
Ensembl chr 8:25,419,258...25,424,654
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased activity of GSK3B protein] CTD PMID:19135050 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions
increases degradation
EXP
ISO
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [1,1-diethyl-2-hydroxy-2-nitrosohydrazine results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [dicyanocobinamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; [BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [3-(2-(2,2-dimethylpropylsulfanyl)pyridin-3-yl)-N-(3-hydroxycyclohexyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [3-(2-(4-chlorophenylsulfanyl)phenyl)-N-(4-dimethylaminobutyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein]
CTD PMID:11744065 PMID:12495780 PMID:17050951 PMID:19466990 PMID:22171090 NCBI chr 4:155,666,848...155,737,059
Ensembl chr 4:155,666,726...155,737,059
JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions
increases degradation
EXP
ISO
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [1,1-diethyl-2-hydroxy-2-nitrosohydrazine results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [dicyanocobinamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; [BAY 58-2667 co-treated with 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one] results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [3-(2-(2,2-dimethylpropylsulfanyl)pyridin-3-yl)-N-(3-hydroxycyclohexyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [3-(2-(4-chlorophenylsulfanyl)phenyl)-N-(4-dimethylaminobutyl)acrylamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one promotes the reaction [BAY 58-2667 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein
CTD PMID:11744065 PMID:12495780 PMID:17050951 PMID:19466990 PMID:22171090 NCBI chr 4:155,759,021...155,807,811
Ensembl chr 4:155,758,992...155,807,811
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Resveratrol results in increased expression of HMOX1 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Resveratrol results in increased expression of HMOX1 protein] CTD PMID:24041027 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G IBSP integrin binding sialoprotein multiple interactions
decreases expression
EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased expression of IBSP mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [NOC 18 results in increased expression of IBSP mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of IBSP mRNA
CTD PMID:22543296 NCBI chr 4:87,799,554...87,812,435
Ensembl chr 4:87,799,554...87,812,435
JBrowse link
G IL12RB2 interleukin 12 receptor subunit beta 2 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [NOC 18 results in increased expression of IL12RB2 mRNA] CTD PMID:12451176 NCBI chr 1:67,307,364...67,398,724
Ensembl chr 1:67,307,364...67,398,724
JBrowse link
G MDM2 MDM2 proto-oncogene increases expression EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased expression of MDM2 protein CTD PMID:16288207 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544
JBrowse link
G NDUFB8 NADH:ubiquinone oxidoreductase subunit B8 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of NDUFB8 protein] CTD PMID:24041027 NCBI chr10:100,523,729...100,529,923
Ensembl chr10:100,523,740...100,530,000
JBrowse link
G NRF1 nuclear respiratory factor 1 multiple interactions ISO
EXP
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Resveratrol results in increased expression of NRF1 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of NRF1 mRNA]
CTD PMID:17179207 PMID:24041027 NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions EXP
ISO
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Resveratrol results in increased expression of PPARGC1A mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of PPARGC1A mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]
CTD PMID:17179207 PMID:24041027 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein] CTD PMID:15617736 NCBI chr10:50,990,888...52,298,350
Ensembl chr10:50,990,888...52,298,423
JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 multiple interactions ISO ODQ inhibits the reaction [SNAP increases activity of Ptpn1 protein in aortic smooth muscle cells] RGD PMID:10484424 RGD:401965470 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA] CTD PMID:14996425 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions
decreases expression
EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in increased expression of SPP1 mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [NOC 18 results in increased expression of SPP1 mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of SPP1 mRNA
CTD PMID:22543296 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532
JBrowse link
G TFAM transcription factor A, mitochondrial multiple interactions EXP
ISO
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Resveratrol results in increased expression of TFAM mRNA]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of TFAM mRNA]
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]
CTD PMID:17179207 PMID:24041027 NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased stability of and results in increased expression of and results in increased phosphorylation of TP53 protein CTD PMID:16288207 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
G UQCRC1 ubiquinol-cytochrome c reductase core protein 1 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of UQCRC1 protein] CTD PMID:24041027 NCBI chr 3:48,599,002...48,609,646
Ensembl chr 3:48,599,002...48,610,976
JBrowse link
G VASP vasodilator stimulated phosphoprotein multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased phosphorylation of VASP protein] CTD PMID:17868048 NCBI chr19:45,507,479...45,526,983
Ensembl chr19:45,506,579...45,526,989
JBrowse link
G XIAP X-linked inhibitor of apoptosis decreases activity EXP XIAP protein results in decreased activity of 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one CTD PMID:16288207 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972
JBrowse link
6-anilino-5,8-quinolinedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
EXP 6-anilino-5,8-quinolinedione inhibits the reaction [sodium bichromate results in increased ubiquitination of BCL2 protein]
6-anilino-5,8-quinolinedione results in decreased expression of BCL2 protein
CTD PMID:18544562 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BDNF brain derived neurotrophic factor decreases response to substance EXP BDNF protein results in decreased susceptibility to 6-anilino-5,8-quinolinedione CTD PMID:22261313 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO 6-anilino-5,8-quinolinedione results in increased expression of and results in increased secretion of HSP90AA1 protein CTD PMID:10617604 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 increases expression ISO 6-anilino-5,8-quinolinedione results in increased expression of HSP90AB1 protein CTD PMID:10617604 NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888
JBrowse link
G IL4 interleukin 4 decreases secretion ISO 6-anilino-5,8-quinolinedione results in decreased secretion of IL4 protein CTD PMID:16533816 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL5 interleukin 5 decreases secretion ISO 6-anilino-5,8-quinolinedione results in decreased secretion of IL5 protein CTD PMID:16533816 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838
JBrowse link
G IL6 interleukin 6 multiple interactions EXP 6-anilino-5,8-quinolinedione inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:35122928 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP 6-anilino-5,8-quinolinedione inhibits the reaction [heat stable toxin (E coli) results in decreased expression of VEGFA protein] CTD PMID:17828804 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
methylene blue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) decreases activity EXP Methylene Blue results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 multiple interactions ISO Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of ATP1A2 protein] CTD PMID:31173149 NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein] CTD PMID:31428839 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein] CTD PMID:31428839 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C multiple interactions ISO Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of CACNA1C protein] CTD PMID:31173149 NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950
JBrowse link
G CALCA calcitonin related polypeptide alpha multiple interactions ISO Methylene Blue inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA] CTD PMID:11919648 NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase increases activity EXP Methylene Blue results in increased activity of G6PD protein CTD PMID:1901343 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions
increases expression
ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA] CTD PMID:24556215 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA CTD PMID:24556215 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein] CTD PMID:24556215 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GLRX glutaredoxin multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA CTD PMID:24556215 NCBI chr 5:95,813,849...95,822,726
Ensembl chr 5:95,751,319...95,822,726
JBrowse link
G GLRX2 glutaredoxin 2 multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA CTD PMID:24556215 NCBI chr 1:193,096,465...193,106,114
Ensembl chr 1:193,090,866...193,106,114
JBrowse link
G GNRH1 gonadotropin releasing hormone 1 multiple interactions ISO Methylene Blue inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:17290048 NCBI chr 8:25,419,258...25,425,040
Ensembl chr 8:25,419,258...25,424,654
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP Methylene Blue inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]
Methylene Blue results in increased expression of HMOX1 protein
CTD PMID:24556215 PMID:25943564 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein] CTD PMID:31428839 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IL17A interleukin 17A multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein] CTD PMID:31428839 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G IL6 interleukin 6 multiple interactions ISO Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] CTD PMID:31428839 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IYD iodotyrosine deiodinase multiple interactions EXP Methylene Blue inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 6:150,369,012...150,405,969
Ensembl chr 6:150,368,892...150,405,969
JBrowse link
G MAOB monoamine oxidase B multiple interactions
decreases activity
EXP Methylene Blue inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]
Methylene Blue results in decreased activity of MAOB protein
CTD PMID:21554916 NCBI chr  X:43,766,610...43,882,450
Ensembl chr  X:43,766,610...43,882,450
JBrowse link
G MAPT microtubule associated protein tau decreases expression
multiple interactions
decreases phosphorylation
increases expression
EXP
ISO
Methylene Blue results in decreased expression of MAPT protein
[Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA; Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA]; Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA]; Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein]
Methylene Blue results in decreased phosphorylation of MAPT protein modified form
Methylene Blue results in increased expression of MAPT mRNA
CTD PMID:16930453 PMID:24556215 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334
JBrowse link
G MPO myeloperoxidase multiple interactions ISO Methylene Blue inhibits the reaction [Paraquat results in increased expression of MPO protein]; Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein] CTD PMID:25943564 PMID:31428839 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA]
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA]
CTD PMID:24556215 PMID:31428839 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]
CTD PMID:24556215 PMID:31428839 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA] CTD PMID:24556215 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PGD phosphogluconate dehydrogenase increases activity EXP Methylene Blue results in increased activity of PGD protein CTD PMID:1901343 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G PRDX6 peroxiredoxin 6 multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA CTD PMID:24556215 NCBI chr 1:173,477,335...173,488,815
Ensembl chr 1:173,477,330...173,488,815
JBrowse link
G PRKCE protein kinase C epsilon multiple interactions ISO Methylene Blue inhibits the reaction [Sodium Cyanide results in increased activity of and affects the localization of PRKCE protein] CTD PMID:31173149 NCBI chr 2:45,651,279...46,187,990
Ensembl chr 2:45,651,345...46,187,990
JBrowse link
G SLC2A1 solute carrier family 2 member 1 multiple interactions
increases activity
ISO oxophenylarsine inhibits the reaction [Methylene Blue results in increased activity of SLC2A1 protein] CTD PMID:19686715 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Methylene Blue inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein] CTD PMID:11744139 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 affects activity EXP Methylene Blue affects the activity of TP53 protein CTD PMID:35435491 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
G TXN thioredoxin multiple interactions ISO Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA] CTD PMID:24556215 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
G TXN2 thioredoxin 2 multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA CTD PMID:24556215 NCBI chr22:36,467,046...36,481,640
Ensembl chr22:36,467,046...36,481,640
JBrowse link
G TXNRD1 thioredoxin reductase 1 multiple interactions ISO Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA] CTD PMID:24556215 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G TXNRD2 thioredoxin reductase 2 multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA CTD PMID:24556215 NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26447
    role 26279
      biological role 26258
        biochemical role 25464
          enzyme inhibitor 22391
            EC 4.* (lyase) inhibitor 8203
              EC 4.6.* (P-O lyase) inhibitor 75
                EC 4.6.1.2 (guanylate cyclase) inhibitor 70
                  1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one 33
                  6-anilino-5,8-quinolinedione 8
                  methylene blue 35
paths to the root