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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:6-anilino-5,8-quinolinedione
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Accession:CHEBI:78677 term browser browse the term
Definition:A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group.
Synonyms:exact_synonym: 6-anilinoquinoline-5,8-dione
 related_synonym: 6-(Phenylamino)-5,8-quinolinedione;   Formula=C15H10N2O2;   InChI=1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H;   InChIKey=GXIJYWUWLNHKNW-UHFFFAOYSA-N;   LY 83583;   SMILES=O=C1C=C(Nc2ccccc2)C(=O)c2cccnc12
 xref: CAS:91300-60-6;   LINCS:LSM-3393
 xref_mesh: MESH:C041715
 xref: PMID:10064158;   PMID:1425959;   PMID:22508834;   PMID:2552329;   PMID:2902213;   PMID:8338131;   PMID:9572303;   Reaxys:207004


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6-anilino-5,8-quinolinedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO 6-anilino-5,8-quinolinedione inhibits the reaction [sodium bichromate results in increased ubiquitination of BCL2 protein]
6-anilino-5,8-quinolinedione results in decreased expression of BCL2 protein
CTD PMID:18544562 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor decreases response to substance ISO BDNF protein results in decreased susceptibility to 6-anilino-5,8-quinolinedione CTD PMID:22261313 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions EXP 6-anilino-5,8-quinolinedione results in increased expression of and results in increased secretion of HSP90AA1 protein CTD PMID:10617604 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression EXP 6-anilino-5,8-quinolinedione results in increased expression of HSP90AB1 protein CTD PMID:10617604 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Il4 interleukin 4 decreases secretion ISO 6-anilino-5,8-quinolinedione results in decreased secretion of IL4 protein CTD PMID:16533816 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 decreases secretion ISO 6-anilino-5,8-quinolinedione results in decreased secretion of IL5 protein CTD PMID:16533816 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 6-anilino-5,8-quinolinedione inhibits the reaction [heat stable toxin (E coli) results in decreased expression of VEGFA protein] CTD PMID:17828804 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            antineoplastic agent 17317
              6-anilino-5,8-quinolinedione 7
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      ketone 16923
                                        cyclic ketone 15391
                                          quinone 8379
                                            p-quinones 8285
                                              6-anilino-5,8-quinolinedione 7
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