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ONTOLOGY REPORT - ANNOTATIONS


Term:borrelidin
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Accession:CHEBI:78661 term browser browse the term
Definition:A macrolide that is isolated from several Streptomyces species and displays antibiotic, antineoplastic and antimalarial properties.
Synonyms:exact_synonym: (1R,2R)-2-[(2R,4E,6Z,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid
 related_synonym: Formula=C28H43NO6;   InChI=1S/C28H43NO6/c1-17-12-18(2)14-20(4)27(32)21(16-29)8-5-6-11-25(22-9-7-10-23(22)28(33)34)35-26(31)15-24(30)19(3)13-17/h5-6,8,17-20,22-25,27,30,32H,7,9-15H2,1-4H3,(H,33,34)/b6-5+,21-8-/t17-,18+,19-,20-,22+,23+,24-,25+,27+/m0/s1;   InChIKey=OJCKRNPLOZHAOU-JTHVHBRGSA-N;   SMILES=C[C@H]1C[C@@H](C)C[C@H](C)[C@@H](O)\\C(=C/C=C/C[C@@H](OC(=O)C[C@H](O)[C@@H](C)C1)[C@@H]1CCC[C@H]1C(O)=O)C#N;   Treponemycin
 xref: CAS:7184-60-3 "ChemIDplus";   CAS:7184-60-3 "KEGG COMPOUND";   KEGG:C15687
 xref_mesh: MESH:C005066
 xref: MetaCyc:CPD0-1348;   PMID:21343942 "Europe PMC";   PMID:21472957 "Europe PMC";   PMID:21678129 "Europe PMC";   PMID:22242825 "Europe PMC";   PMID:22313786 "Europe PMC";   PMID:22707527 "Europe PMC";   PMID:22822423 "Europe PMC";   PMID:22967236 "Europe PMC";   PMID:23488671 "Europe PMC";   PMID:24131731 "Europe PMC";   PMID:24155182 "Europe PMC";   PMID:24562907 "Europe PMC";   PMID:24778714 "Europe PMC";   PMID:24794971 "Europe PMC";   PMID:3680012 "Europe PMC";   Reaxys:5782155 "Reaxys"


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borrelidin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Eif2a eukaryotic translation initiation factor 2A JBrowse link 2 148,722,343 148,755,781 RGD:6480464
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link 3 110,159,624 110,245,382 RGD:6480464
G Tars1 threonyl-tRNA synthetase 1 JBrowse link 2 61,394,632 61,414,115 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Wbp4 WW domain binding protein 4 JBrowse link 15 61,745,989 61,772,516 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        antimicrobial agent 17151
          borrelidin 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic ester 13934
                                        lactone 5859
                                          macrocyclic lactone 1515
                                            macrolide 1454
                                              borrelidin 9
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.