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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:borrelidin
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Accession:CHEBI:78661 term browser browse the term
Definition:A macrolide that is isolated from several Streptomyces species and displays antibiotic, antineoplastic and antimalarial properties.
Synonyms:exact_synonym: (1R,2R)-2-[(2R,4E,6Z,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid
 related_synonym: Formula=C28H43NO6;   InChI=1S/C28H43NO6/c1-17-12-18(2)14-20(4)27(32)21(16-29)8-5-6-11-25(22-9-7-10-23(22)28(33)34)35-26(31)15-24(30)19(3)13-17/h5-6,8,17-20,22-25,27,30,32H,7,9-15H2,1-4H3,(H,33,34)/b6-5+,21-8-/t17-,18+,19-,20-,22+,23+,24-,25+,27+/m0/s1;   InChIKey=OJCKRNPLOZHAOU-JTHVHBRGSA-N;   SMILES=C[C@H]1C[C@@H](C)C[C@H](C)[C@@H](O)\\C(=C/C=C/C[C@@H](OC(=O)C[C@H](O)[C@@H](C)C1)[C@@H]1CCC[C@H]1C(O)=O)C#N;   Treponemycin
 xref: CAS:7184-60-3;   KEGG:C15687
 xref_mesh: MESH:C005066
 xref: MetaCyc:CPD0-1348;   PMID:21343942;   PMID:21472957;   PMID:21678129;   PMID:22242825;   PMID:22313786;   PMID:22707527;   PMID:22822423;   PMID:22967236;   PMID:23488671;   PMID:24131731;   PMID:24155182;   PMID:24562907;   PMID:24778714;   PMID:24794971;   PMID:3680012;   Reaxys:5782155


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borrelidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases response to substance ISO BCL2 protein results in decreased susceptibility to borrelidin CTD PMID:24155182 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO borrelidin results in increased activity of CASP3 protein
borrelidin results in increased cleavage of CASP3 protein
CTD PMID:14563161 PMID:26271225 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO borrelidin results in increased activity of CASP8 protein CTD PMID:14563161 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO borrelidin results in increased expression of DDIT3 protein CTD PMID:21678129 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO borrelidin results in increased phosphorylation of EIF2A protein CTD PMID:26271225 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 increases activity ISO borrelidin results in increased activity of EIF2AK4 protein CTD PMID:21678129 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases activity
multiple interactions
ISO borrelidin results in decreased activity of TARS1 protein
borrelidin analog binds to and affects the folding of TARS1 protein; borrelidin binds to and affects the folding of TARS1 protein; borrelidin binds to and results in decreased activity of TARS1 protein
CTD PMID:25489076 PMID:25824639 PMID:26271225 NCBI chr 2:60,368,251...60,387,733
Ensembl chr 2:60,367,796...60,387,717
JBrowse link
G Vegfa vascular endothelial growth factor A affects splicing
multiple interactions
ISO borrelidin affects the splicing of VEGFA mRNA; borrelidin analog affects the splicing of VEGFA mRNA
borrelidin analog inhibits the reaction [WBP4 protein affects the splicing of VEGFA mRNA]
CTD PMID:22822423 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Wbp4 WW domain binding protein 4 affects binding
multiple interactions
ISO borrelidin analog binds to WBP4 protein; borrelidin binds to WBP4 protein
borrelidin analog inhibits the reaction [WBP4 protein affects the splicing of VEGFA mRNA]
CTD PMID:22822423 NCBI chr15:54,862,700...54,890,668
Ensembl chr15:54,862,843...54,890,647
JBrowse link

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  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          borrelidin 9
Path 2
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic ester 15889
                                        lactone 11245
                                          macrocyclic lactone 5532
                                            macrolide 5480
                                              borrelidin 9
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