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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:edelfosine
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Accession:CHEBI:78649 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
Synonyms:exact_synonym: rac-2-methoxy-3-(octadecyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
 related_synonym: 1-O-Octadecyl-2-O-methyl-rac-glyceryl-3-phosphorylcholine;   1-Octadecyl-2-methylglycero-3-phosphorylcholine;   2-methoxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate;   ET 18-OCH3;   ET-18-OMe;   Formula=C27H58NO6P;   Racemic 1-O-octadecyl-2-O-methylglycero-3-phosphocholine;   edelfosina;   edelfosinum;   rac-1-Octadecyl-2-methoxyglycero-3-phosphocholine
 xref: CAS:70641-51-9
 xref_mesh: MESH:C026659
 xref: PMID:23164800;   PMID:23353057;   PMID:23643510;   PMID:23738749;   PMID:24299925;   PMID:24413065;   PMID:24448421;   PMID:24628232;   PMID:24628234;   PMID:24628237;   PMID:24628238;   PMID:24628241;   PMID:24667731;   PMID:24678709;   PMID:24694892;   PMID:4038380;   Patent:EP1091744;   Patent:WO0001392;   Reaxys:4358577;   Wikipedia:Edelfosine


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edelfosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein]; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]; edelfosine promotes the reaction [Cytarabine results in decreased expression of BCL2 protein] CTD PMID:9295281, PMID:12421819 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Lep leptin multiple interactions ISO edelfosine inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Plcb2 phospholipase C, beta 2 multiple interactions ISO edelfosine inhibits the reaction [Cytarabine affects the localization of PLCB2 protein]; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PLCB2 protein] CTD PMID:9295281 NCBI chr 3:110,497,760...110,517,563
Ensembl chr 3:110,498,114...110,517,163
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO edelfosine results in increased expression of PTGS2 protein CTD PMID:12485854 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      chemical substance 11928
        mixture 10845
          racemate 9741
            edelfosine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      chalcogen 19362
                        oxygen atom 19323
                          oxygen molecular entity 19323
                            hydroxides 19068
                              oxoacid 18193
                                pnictogen oxoacid 10146
                                  phosphorus oxoacid 9033
                                    phosphoric acids 7795
                                      phosphoric acid 7795
                                        phosphoric acid derivative 7474
                                          phosphate 7474
                                            organic phosphate 7473
                                              phospholipid 289
                                                glycerophospholipid 196
                                                  glycerophosphocholine 115
                                                    1-octadecyl-2-methylglycero-3-phosphocholine 6
                                                      (R)-edelfosine 6
                                                        edelfosine 6
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