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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:edelfosine
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Accession:CHEBI:78649 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
Synonyms:exact_synonym: rac-2-methoxy-3-(octadecyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
 related_synonym: 1-O-Octadecyl-2-O-methyl-rac-glyceryl-3-phosphorylcholine;   1-Octadecyl-2-methylglycero-3-phosphorylcholine;   2-methoxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate;   ET 18-OCH3;   ET-18-OMe;   Formula=C27H58NO6P;   Racemic 1-O-octadecyl-2-O-methylglycero-3-phosphocholine;   edelfosina;   edelfosinum;   rac-1-Octadecyl-2-methoxyglycero-3-phosphocholine
 xref: CAS:70641-51-9
 xref_mesh: MESH:C026659
 xref: PMID:23164800;   PMID:23353057;   PMID:23643510;   PMID:23738749;   PMID:24299925;   PMID:24413065;   PMID:24448421;   PMID:24628232;   PMID:24628234;   PMID:24628237;   PMID:24628238;   PMID:24628241;   PMID:24667731;   PMID:24678709;   PMID:24694892;   PMID:4038380;   Patent:EP1091744;   Patent:WO0001392;   Reaxys:4358577;   Wikipedia:Edelfosine

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edelfosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein]; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]; edelfosine promotes the reaction [Cytarabine results in decreased expression of BCL2 protein] CTD PMID:9295281 PMID:12421819 NCBI chr13:22,689,783...22,853,920 JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Lep leptin multiple interactions ISO edelfosine inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Plcb2 phospholipase C, beta 2 multiple interactions ISO edelfosine inhibits the reaction [Cytarabine affects the localization of PLCB2 protein]; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PLCB2 protein] CTD PMID:9295281 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO edelfosine results in increased expression of PTGS2 protein CTD PMID:12485854 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      chemical substance 12978
        mixture 12149
          racemate 10091
            edelfosine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      chalcogen 19469
                        oxygen atom 19445
                          oxygen molecular entity 19445
                            hydroxides 19180
                              oxoacid 18498
                                pnictogen oxoacid 10685
                                  phosphorus oxoacid 9666
                                    phosphoric acids 8466
                                      phosphoric acid 8466
                                        phosphoric acid derivative 8172
                                          phosphate 8172
                                            organic phosphate 8171
                                              phospholipid 302
                                                glycerophospholipid 203
                                                  glycerophosphocholine 118
                                                    1-octadecyl-2-methylglycero-3-phosphocholine 6
                                                      (R)-edelfosine 6
                                                        edelfosine 6
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