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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:edelfosine
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Accession:CHEBI:78649 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
Synonyms:exact_synonym: rac-2-methoxy-3-(octadecyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
 related_synonym: 1-O-Octadecyl-2-O-methyl-rac-glyceryl-3-phosphorylcholine;   1-Octadecyl-2-methylglycero-3-phosphorylcholine;   2-methoxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate;   ET 18-OCH3;   ET-18-OMe;   Formula=C27H58NO6P;   Racemic 1-O-octadecyl-2-O-methylglycero-3-phosphocholine;   edelfosina;   edelfosinum;   rac-1-Octadecyl-2-methoxyglycero-3-phosphocholine
 xref: CAS:70641-51-9
 xref_mesh: MESH:C026659
 xref: PMID:23164800;   PMID:23353057;   PMID:23643510;   PMID:23738749;   PMID:24299925;   PMID:24413065;   PMID:24448421;   PMID:24628232;   PMID:24628234;   PMID:24628237;   PMID:24628238;   PMID:24628241;   PMID:24667731;   PMID:24678709;   PMID:24694892;   PMID:4038380;   Patent:EP1091744;   Patent:WO0001392;   Reaxys:4358577;   Wikipedia:Edelfosine



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edelfosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein]; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]; edelfosine promotes the reaction [Cytarabine results in decreased expression of BCL2 protein] CTD PMID:9295281 PMID:12421819 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Lep leptin multiple interactions ISO edelfosine inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Plcb2 phospholipase C, beta 2 multiple interactions ISO edelfosine inhibits the reaction [Cytarabine affects the localization of PLCB2 protein]; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PLCB2 protein] CTD PMID:9295281 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO edelfosine results in increased expression of PTGS2 protein CTD PMID:12485854 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19860
    chemical entity 19858
      chemical substance 14411
        mixture 13732
          racemate 12107
            edelfosine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    p-block element atom 19804
                      chalcogen 19555
                        oxygen atom 19528
                          oxygen molecular entity 19528
                            hydroxides 19335
                              oxoacid 18769
                                pnictogen oxoacid 14903
                                  phosphorus oxoacid 14492
                                    phosphoric acids 13930
                                      phosphoric acid 13930
                                        phosphoric acid derivative 13836
                                          phosphate 13835
                                            organic phosphate 13835
                                              phospholipid 316
                                                glycerophospholipid 211
                                                  glycerophosphocholine 124
                                                    1-octadecyl-2-methylglycero-3-phosphocholine 6
                                                      (R)-edelfosine 6
                                                        edelfosine 6
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