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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:edelfosine
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Accession:CHEBI:78649 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
Synonyms:exact_synonym: rac-2-methoxy-3-(octadecyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
 related_synonym: 1-O-Octadecyl-2-O-methyl-rac-glyceryl-3-phosphorylcholine;   1-Octadecyl-2-methylglycero-3-phosphorylcholine;   2-methoxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate;   ET 18-OCH3;   ET-18-OMe;   Formula=C27H58NO6P;   Racemic 1-O-octadecyl-2-O-methylglycero-3-phosphocholine;   edelfosina;   edelfosinum;   rac-1-Octadecyl-2-methoxyglycero-3-phosphocholine
 xref: CAS:70641-51-9
 xref_mesh: MESH:C026659
 xref: PMID:23164800;   PMID:23353057;   PMID:23643510;   PMID:23738749;   PMID:24299925;   PMID:24413065;   PMID:24448421;   PMID:24628232;   PMID:24628234;   PMID:24628237;   PMID:24628238;   PMID:24628241;   PMID:24667731;   PMID:24678709;   PMID:24694892;   PMID:4038380;   Patent:EP1091744;   Patent:WO0001392;   Reaxys:4358577;   Wikipedia:Edelfosine


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edelfosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein]; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]; edelfosine promotes the reaction [Cytarabine results in decreased expression of BCL2 protein] CTD PMID:9295281 PMID:12421819 NCBI chr13:22,689,783...22,853,920 JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Lep leptin multiple interactions ISO edelfosine inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Plcb2 phospholipase C, beta 2 multiple interactions ISO edelfosine inhibits the reaction [Cytarabine affects the localization of PLCB2 protein]; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PLCB2 protein] CTD PMID:9295281 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO edelfosine results in increased expression of PTGS2 protein CTD PMID:12485854 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    chemical entity 20088
      chemical substance 13325
        mixture 12455
          racemate 10556
            edelfosine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      chalcogen 19732
                        oxygen atom 19674
                          oxygen molecular entity 19674
                            hydroxides 19454
                              oxoacid 18744
                                pnictogen oxoacid 11007
                                  phosphorus oxoacid 9818
                                    phosphoric acids 8644
                                      phosphoric acid 8639
                                        phosphoric acid derivative 8348
                                          phosphate 8348
                                            organic phosphate 8342
                                              phospholipid 310
                                                glycerophospholipid 209
                                                  glycerophosphocholine 123
                                                    1-octadecyl-2-methylglycero-3-phosphocholine 6
                                                      (R)-edelfosine 6
                                                        edelfosine 6
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