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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:edelfosine
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Accession:CHEBI:78649 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
Synonyms:exact_synonym: rac-2-methoxy-3-(octadecyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
 related_synonym: 1-O-Octadecyl-2-O-methyl-rac-glyceryl-3-phosphorylcholine;   1-Octadecyl-2-methylglycero-3-phosphorylcholine;   2-methoxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate;   ET 18-OCH3;   ET-18-OMe;   Formula=C27H58NO6P;   Racemic 1-O-octadecyl-2-O-methylglycero-3-phosphocholine;   edelfosina;   edelfosinum;   rac-1-Octadecyl-2-methoxyglycero-3-phosphocholine
 xref: CAS:70641-51-9
 xref_mesh: MESH:C026659
 xref: PMID:23164800;   PMID:23353057;   PMID:23643510;   PMID:23738749;   PMID:24299925;   PMID:24413065;   PMID:24448421;   PMID:24628232;   PMID:24628234;   PMID:24628237;   PMID:24628238;   PMID:24628241;   PMID:24667731;   PMID:24678709;   PMID:24694892;   PMID:4038380;   Patent:EP1091744;   Patent:WO0001392;   Reaxys:4358577;   Wikipedia:Edelfosine


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edelfosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein]; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]; edelfosine promotes the reaction [Cytarabine results in decreased expression of BCL2 protein] CTD PMID:9295281 PMID:12421819 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Lep leptin multiple interactions ISO edelfosine inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Plcb2 phospholipase C, beta 2 multiple interactions ISO edelfosine inhibits the reaction [Cytarabine affects the localization of PLCB2 protein]; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PLCB2 protein] CTD PMID:9295281 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO edelfosine results in increased expression of PTGS2 protein CTD PMID:12485854 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    chemical entity 19919
      chemical substance 14418
        mixture 13731
          racemate 12103
            edelfosine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      chalcogen 19616
                        oxygen atom 19589
                          oxygen molecular entity 19589
                            hydroxides 19384
                              oxoacid 18756
                                pnictogen oxoacid 13138
                                  phosphorus oxoacid 12392
                                    phosphoric acids 11426
                                      phosphoric acid 11426
                                        phosphoric acid derivative 11235
                                          phosphate 11234
                                            organic phosphate 11234
                                              phospholipid 312
                                                glycerophospholipid 211
                                                  glycerophosphocholine 124
                                                    1-octadecyl-2-methylglycero-3-phosphocholine 6
                                                      (R)-edelfosine 6
                                                        edelfosine 6
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