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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxymetazoline
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Accession:CHEBI:7862 term browser browse the term
Definition:A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion.
Synonyms:exact_synonym: 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
 related_synonym: 2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline;   3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol;   6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol;   6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol;   Formula=C16H24N2O;   InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18);   InChIKey=WYWIFABBXFUGLM-UHFFFAOYSA-N;   SMILES=Cc1cc(c(O)c(C)c1CC1=NCCN1)C(C)(C)C;   oxymetazolina;   oxymetazolinum
 xref: CAS:1491-59-4;   DrugBank:DB00935;   Drug_Central:2032;   HMDB:HMDB0015070;   KEGG:C07363;   KEGG:D08322;   LINCS:LSM-2353
 xref_mesh: MESH:D010109
 xref: PMID:10487000;   PMID:21177487;   PMID:23679077;   PMID:23988443;   PMID:4003266;   Patent:DE1117588;   Reaxys:886303;   Wikipedia:Oxymetazoline
 cyclic_relationship: is_conjugate_base_of CHEBI:77716


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oxymetazoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions
affects binding		 ISO
EXP		 [Oxymetazoline binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; Oxymetazoline binds to and results in increased activity of ADRA1A protein; Oxymetazoline inhibits the reaction [ADRA1A protein binds to Prazosin]; Oxymetazoline inhibits the reaction [Prazosin binds to ADRA1A protein]
Oxymetazoline binds to ADRA1A protein		 CTD PMID:8196478 PMID:15872040 PMID:20030735 PMID:21544540 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions
affects binding		 ISO Oxymetazoline inhibits the reaction [ADRA1B protein binds to Prazosin]
Oxymetazoline binds to ADRA1B protein		 CTD PMID:20030735 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions
affects binding		 ISO Oxymetazoline inhibits the reaction [ADRA1D protein binds to Prazosin]
Oxymetazoline binds to ADRA1D protein		 CTD PMID:15493479 PMID:20030735 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions
affects binding		 ISO Oxymetazoline inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]
Oxymetazoline binds to ADRA2A protein		 CTD PMID:20030735 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO [Oxymetazoline binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; Oxymetazoline binds to and results in increased activity of ADRA2B protein; Oxymetazoline inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan] CTD PMID:20030735 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355 		JBrowse link
G Adra2c adrenoceptor alpha 2C affects binding
multiple interactions		 ISO Oxymetazoline binds to ADRA2C protein
Oxymetazoline inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]		 CTD PMID:20030735 NCBI chr14:75,471,143...75,472,846
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP2C19 protein co-treated with NADP] results in increased metabolism of Oxymetazoline CTD PMID:21177487 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Oxymetazoline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            nasal decongestant 563
              oxymetazoline 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteromonocyclic compound 17120
                                    diazoline 70
                                      imidazolines 70
                                        oxymetazoline 8
paths to the root