Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxymetazoline
go back to main search page
Accession:CHEBI:7862 term browser browse the term
Definition:A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion.
Synonyms:exact_synonym: 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
 related_synonym: 2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline;   3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol;   6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol;   6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol;   Formula=C16H24N2O;   InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18);   InChIKey=WYWIFABBXFUGLM-UHFFFAOYSA-N;   SMILES=Cc1cc(c(O)c(C)c1CC1=NCCN1)C(C)(C)C;   oxymetazolina;   oxymetazolinum
 xref: CAS:1491-59-4;   DrugBank:DB00935;   Drug_Central:2032;   HMDB:HMDB0015070;   KEGG:C07363;   KEGG:D08322;   LINCS:LSM-2353
 xref_mesh: MESH:D010109
 xref: PMID:10487000;   PMID:21177487;   PMID:23679077;   PMID:23988443;   PMID:4003266;   Patent:DE1117588;   Reaxys:886303;   Wikipedia:Oxymetazoline
 cyclic_relationship: is_conjugate_base_of CHEBI:77716


show annotations for term's descendants           Sort by:
 
oxymetazoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions
affects binding
ISO
EXP
[Oxymetazoline binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; Oxymetazoline binds to and results in increased activity of ADRA1A protein; Oxymetazoline inhibits the reaction [ADRA1A protein binds to Prazosin]; Oxymetazoline inhibits the reaction [Prazosin binds to ADRA1A protein]
Oxymetazoline binds to ADRA1A protein
CTD PMID:8196478 PMID:15872040 PMID:20030735 PMID:21544540 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions
affects binding
ISO Oxymetazoline inhibits the reaction [ADRA1B protein binds to Prazosin]
Oxymetazoline binds to ADRA1B protein
CTD PMID:20030735 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions
affects binding
ISO Oxymetazoline inhibits the reaction [ADRA1D protein binds to Prazosin]
Oxymetazoline binds to ADRA1D protein
CTD PMID:15493479 PMID:20030735 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions
affects binding
ISO Oxymetazoline inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]
Oxymetazoline binds to ADRA2A protein
CTD PMID:20030735 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO [Oxymetazoline binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; Oxymetazoline binds to and results in increased activity of ADRA2B protein; Oxymetazoline inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan] CTD PMID:20030735 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987
JBrowse link
G Adra2c adrenoceptor alpha 2C affects binding
multiple interactions
ISO Oxymetazoline binds to ADRA2C protein
Oxymetazoline inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]
CTD PMID:20030735 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP2C19 protein co-treated with NADP] results in increased metabolism of Oxymetazoline CTD PMID:21177487 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Oxymetazoline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      application 19465
        pharmaceutical 19338
          drug 19338
            nasal decongestant 560
              oxymetazoline 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic molecule 19556
                              organic cyclic compound 19365
                                organic heterocyclic compound 18486
                                  organic heteromonocyclic compound 16595
                                    diazoline 70
                                      imidazolines 70
                                        oxymetazoline 8
paths to the root