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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:11-dehydrocorticosterone
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Accession:CHEBI:78600 term browser browse the term
Definition:An 11-oxo steroid that is corticosterone in which the hydroxy substituent at the 11beta position has been oxidised to give the corresponding ketone.
Synonyms:related_synonym: 11-DHC;   11-oxo-11-deoxycorticosterone;   17-(1-keto-2-hydroxyethyl)-Delta(4)androsten-3,11-dione;   17-deoxycortisone;   4-Pregnen-21-ol-3,11,20-trione;   Delta(4)-pregnen-21-ol-3,11,20-trione;   Formula=C21H28O4;   InChI=1S/C21H28O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-16,19,22H,3-8,10-11H2,1-2H3/t14-,15-,16+,19+,20-,21-/m0/s1;   InChIKey=FUFLCEKSBBHCMO-KJQYFISQSA-N;   Kendall's compound A;   SMILES=C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO;   dehydrocorticosterone
 alt_id: CHEBI:711
 xref: CAS:72-23-1;   HMDB:HMDB0004029;   KEGG:C05490;   LIPID_MAPS_instance:LMST02030192
 xref_mesh: MESH:C003552
 xref: PMID:11751610;   PMID:17329828;   PMID:17389675;   PMID:1951719;   PMID:23832962;   PMID:4295227;   PMID:8430442;   PMID:8498539;   PMID:8613810;   Patent:US2778776;   Reaxys:3108660


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11-dehydrocorticosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases metabolic processing
increases reduction
affects abundance
multiple interactions
affects response to substance
ISO
EXP
HSD11B1 protein results in increased metabolism of 11-dehydrocorticosterone
HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone
HSD11B1 gene mutant form affects the abundance of 11-dehydrocorticosterone
[HSD11B1 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone; Resveratrol inhibits the reaction [HSD11B1 protein results in increased metabolism of 11-dehydrocorticosterone]; Ziram inhibits the reaction [[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone]; Ziram inhibits the reaction [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone]
HSD11B1 gene affects the susceptibility to 11-dehydrocorticosterone
CTD PMID:16751407 PMID:23814014 PMID:25061560 PMID:26859423 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions EXP [HSD11B2 protein results in increased metabolism of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; [HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone] CTD PMID:26859423 PMID:32243540 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO 11-dehydrocorticosterone results in increased expression of IL6 mRNA
11-dehydrocorticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]
CTD PMID:30993381 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
increases expression
EXP Carbenoxolone inhibits the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [11-dehydrocorticosterone results in increased expression of SGK1 mRNA] CTD PMID:16533503 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      group 19733
        organic group 18728
          3-oxo-Delta(4)-steroid group 8423
            3-oxo-Delta(4) steroid 8423
              11-dehydrocorticosterone 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        oxyketone 8656
                                          alpha-oxyketone 8656
                                            alpha-hydroxy ketone 8656
                                              primary alpha-hydroxy ketone 7537
                                                corticosterone 335
                                                  11-dehydrocorticosterone 4
paths to the root