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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:21-dehydrocortisol
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Accession:CHEBI:78595 term browser browse the term
Definition:A C21-steroid that is cortisol in which the 21-hydroxy group has been oxidised to the corresponding aldehyde.
Synonyms:exact_synonym: (11beta)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-al
 related_synonym: 11beta,17-dihydroxy-21-oxoprogesterone;   11beta,17alpha-dihydroxypregn-4-en-3,20-dione-21-al;   11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione;   4-pregnen-11beta,17alpha-diol-3,20-dione-21-al;   Formula=C21H28O5;   InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,11,14-16,18,24,26H,3-8,10H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1;   InChIKey=JIELFMXLFHFDRT-VWUMJDOOSA-N;   SMILES=C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@]2(O)C(=O)C=O
 xref: CAS:14760-49-7
 xref_mesh: MESH:C026547
 xref: PMID:1112882;   PMID:170263;   PMID:171488;   PMID:5413721;   PMID:5685579;   PMID:7098476;   PMID:7439163;   Reaxys:4564511


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21-dehydrocortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of 21-dehydrocortisol CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    chemical entity 19771
      group 19689
        organic group 18599
          3-oxo-Delta(4)-steroid group 8425
            3-oxo-Delta(4) steroid 8425
              21-dehydrocortisol 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        carboacyl group 17416
                                          univalent carboacyl group 17416
                                            formyl group 8794
                                              aldehyde 8794
                                                steroid aldehyde 90
                                                  21-dehydrocortisol 1
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