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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aflatoxin Q1
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Accession:CHEBI:78582 term browser browse the term
Definition:A member of the class of aflatoxins that is aflatoxin B1 in which the hydrogen at the pro-3S position is replaced by a hydroxy group.
Synonyms:exact_synonym: (3S,6aR,9aS)-3-hydroxy-4-methoxy-2,3,6a,9a-tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene-1,11-dione
 related_synonym: AFQ1;   Formula=C17H12O7;   InChI=1S/C17H12O7/c1-21-9-5-10-11(6-2-3-22-17(6)23-10)15-14(9)12-7(18)4-8(19)13(12)16(20)24-15/h2-3,5-7,17-18H,4H2,1H3/t6-,7-,17+/m0/s1;   InChIKey=GYNOTJLCULOEIM-XKRJZGAWSA-N;   SMILES=COc1cc2O[C@H]3OC=C[C@H]3c2c2oc(=O)c3C(=O)C[C@H](O)c3c12
 xref: CAS:52819-96-2;   HMDB:HMDB0030753;   KEGG:C19585;   KNApSAcK:C00023624
 xref_mesh: MESH:C033759
 xref: PMID:1185319;   PMID:1643250;   PMID:3099349;   PMID:3116726;   PMID:3141079;   PMID:4081304;   PMID:6622820;   PMID:6712219;   PMID:6766512;   PMID:7987484;   PMID:9385444;   Reaxys:8866397


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aflatoxin Q1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin Q1 CTD PMID:20707407 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G Gnmt glycine N-methyltransferase decreases secretion ISO GNMT results in decreased secretion of aflatoxin Q1 CTD PMID:19146867 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        aetiopathogenetic role 18973
          carcinogenic agent 18339
            aflatoxin Q1 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17978
                                    organic heteropentacyclic compound 13364
                                      cyclopentafurofurochromene 11506
                                        aflatoxin 11506
                                          aflatoxin B1 11081
                                            aflatoxin Q1 2
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